CN103948727B - A kind of teeth consolidating tooth film easy to use pastes and preparation method thereof - Google Patents

Abstract

The invention discloses a convenient tooth-fixing dental pellicle and a preparation method thereof. The extraction filtrate of the tooth-fixing traditional Chinese medicine components is centrifuged and concentrated to obtain the extract of the tooth-fixing traditional Chinese medicine; ethyl maltol and xylitol are added 1. Chitosan solution is sterilized to obtain a tooth-fixing membrane solution; sodium carboxymethyl cellulose and gelatin composite sol are prepared; the tooth-fixing membrane solution and the composite sol are mixed to form a pre-membrane. The dental membrane patch prepared by the invention has wide applicability, is easy to carry, has strong affinity to teeth, is not easy to fall off, can be applied directly, is convenient to use, does not need to rinse mouth after use, and is suitable for people with loose teeth and people who need nursing care The use provides a new effective way for the development of dental health care products, does not add preservatives, and also meets the new pursuit of modern people. The preparation method has simple process operation and is suitable for industrial scale production.

Description

A kind of easy-to-use fixed-tooth dental membrane and its preparation method

technical field

The invention relates to a dental membrane, in particular to a convenient-to-use dental membrane and a preparation method thereof.

Background technique

Teeth are one of the most important organs of the human body. They have the functions of chewing, assisting pronunciation, and aesthetic appearance. If there is a problem with the teeth, it will not be able to chew food well, and the absorption of food nutrients will be affected, which will lead to frailty and sickness. Healthy teeth allow us to enjoy a variety of foods.

At present, oral disease has been listed as the third largest disease after cancer and cerebrovascular disease. Teeth are one of the most important "checkpoints" for physical health. The latest survey report shows that the prevalence rate of oral diseases such as tooth decay and periodontal disease in my country is as high as 97.6%. Almost everyone has oral problems more or less, so protect your teeth without delay.

Before toothpaste did not appear, people mainly used tooth powder for brushing their teeth, and Chinese people mostly used tooth powder made by grinding Chinese herbal medicines. Later, various toothpastes, chewing gums, and mouthwashes were developed successively.

Toothpaste is not for everyone. The friction between the toothbrush and the teeth may accelerate the loss of the loose teeth and aggravate the toothache. It is not suitable for people with loose teeth, especially for the elderly who need care.

The matrix of chewing gum is very viscous and can remove food residues on the surface of teeth; through chewing movement, mechanical stimulation can increase the secretion of saliva, rinse the surface of the mouth, and have a certain effect of cleaning the mouth; chewing gum can promote facial blood circulation and Muscle exercise can promote the development of teeth and maxillofacial surfaces, but it is not suitable for those with loose teeth; in addition, children chew easily and swallow, causing danger; once the chewing gum sticks to the ground, it is difficult to clean up.

As a kind of oral hygiene product, mouthwash is divided into two categories: health care and therapeutic. Most of the health mouthwashes on the market are mouth fresheners, which are used to remove bad breath and do not have the effect of strengthening teeth. Therapeutic mouthwashes mainly provide auxiliary treatment for common oral problems and must be used under the guidance of professionals.

Chinese patent CN102895340A discloses a preparation method of a toothache patch, which includes the following steps: 1. Chinese herbal medicines are mixed according to the weight percentage of their components; 2. The herbal medicines in the components are dried separately to remove ash and other residues; 3. Mix and crush to 150-200 mesh according to the weight percentage of the components; ④Stir and boil to make a paste; ⑤Put the paste on the cloth base, scrape it flat, and paste it with plastic film; ⑥Cut it into sheets and put it in a box In storage, for sale. The toothache plaster prepared by the present invention is based on the cloth base, which has poor affinity to the teeth and is easy to fall off; since the paste exists on the cloth base, the paste must adhere more or less to the teeth , You must rinse your mouth with water after use, which is not convenient for the elderly who need care.

Contents of the invention

In order to solve the above-mentioned deficiencies in the prior art, the present invention provides an easy-to-use tooth-fixing pellicle and a preparation method thereof. The traditional tooth-fixing formula is presented in the form of a gel-type pellicle, and direct application can alleviate And cure gum swelling and periodontitis, long-term use can prevent periodontal disease, have a better protective effect on the gums, achieve the effect of tooth fixation, especially suitable for those with loose teeth and the elderly who need care.

The purpose of the present invention is achieved through the following technical solutions:

A method for preparing a convenient tooth-fixing dental membrane, comprising the following steps: adding ethyl maltol, xylitol, and chitosan solution to the extraction solution of solid-tooth traditional Chinese medicine to obtain a solid-tooth dental membrane solution; Sodium methylcellulose and gelatin are dissolved in water to make a composite sol solution; after the tooth-fixing dental membrane solution and the composite sol solution are mixed evenly, the mixed solution is pre-filmed.

The above-mentioned preparation method specifically comprises the following steps: (1) adding ethyl maltol, xylitol and chitosan solution to the solid tooth traditional Chinese medicine extract with a density of 900-1100g/L (preferably 1000g/L), After mixing evenly, put it on a water bath at 90-110°C (preferably 100°C) for 20-40 minutes to heat and sterilize it, then place it under ultraviolet radiation and cool it to room temperature to obtain a solid dental membrane solution. The ethyl maltol is 0.15- 0.25g/L extract (preferably 2g/L), xylitol is 450-550g/L extract (preferably 500g/L), and the addition of chitosan solution is 2.5-3.5L/L extract (preferably 3L/L); (2) sodium carboxymethylcellulose and gelatin are dissolved in water to make composite sol solution, and the concentration of two kinds of substances is 1.5-2.5g/L; (3) volume ratio is solid Tooth membrane liquid: the two liquids of composite sol solution = 6-9:0.5-1.5 (preferably 8:1) are mixed evenly, the mixed solution is injected into the dental membrane model, the formed dental membrane is stamped and sealed, and cut into individual teeth Film sticker; the chitosan solution is an aqueous solution in which the concentration of chitosan and citric acid are both 25-35g/L.

The step 3) is specifically under the condition of heating and stirring continuously, mix the tooth-fixing dental membrane solution and the composite sol solution at a volume ratio of 8:1, mix evenly, heat to 90°C, keep for 30 seconds, and keep stirring, in a sterile Cool it to 75°C under the same conditions, inject it into the dental membrane model made by heating and blowing the hard packaging material with compressed air, and wait for the dental membrane to solidify and form into a soft gel shape, then punch and seal the molded dental membrane, and finally automatically separate Cut into individual strips.

The preparation steps of the solid tooth traditional Chinese medicine extract are as follows: (1) pulverize the solid tooth traditional Chinese medicine components to obtain solid tooth powder; (2) weigh 45-55 g of solid tooth powder, and add 12-16 times of water, heated to 90-110°C for hot leaching, solid-liquid separation after 15-30min, collecting the filtrate, cooling, centrifuging at a speed of 3000-4000r/min for 10-20min, and taking the supernatant; ( 3) Put the supernatant in a water bath at 90-110° C. for concentration, and concentrate the extraction filtrate to a density of 900-1100 g/L to obtain a tan extract of solid tooth traditional Chinese medicine.

Preferably, the preparation steps of the extract of solid tooth Chinese medicine are as follows: (1) pulverize the components of solid tooth traditional Chinese medicine to obtain solid tooth powder; Water equivalent to 8 times the weight of the solid tooth powder, heated to 100°C for hot-dip extraction, solid-liquid separation after 15 minutes, and the filtrate was collected; water equivalent to 6 times the weight of the solid tooth powder was added to the filter residue for a second hot-dip extraction , after solid-liquid separation, collect the filtrate, combine the two extracts, cool, centrifuge at a speed of 3600r/min for 15min, and take the supernatant; (3) put the supernatant in a water bath at 100°C for concentration, The leaching filtrate was concentrated to a density of 1000g/L to obtain a tan solid tooth traditional Chinese medicine extract.

The components of the tooth-fixing traditional Chinese medicine are as follows in parts by weight: 4.8-5.2 parts of green salt, 4.8-5.2 parts of gypsum, 3.8-4.2 parts of psoralen, 1.3-1.7 parts of Zanthoxylum bungeanum, 1.3-1.7 parts of Angelica dahurica, 1.3-1.7 parts of peppermint 2.2-2.9 parts of Eclipta, 2.2-2.9 parts of Fangfeng, 1.2-1.8 parts of Asarum.

Preferred are 5 parts of green salt, 5 parts of gypsum, 4 parts of psoralen, 1.5 parts of pepper, 1.5 parts of Angelica dahurica, 1.5 parts of mint, 2.5 parts of Eclipta, 2.5 parts of Fangfeng, and 1.5 parts of Asarum.

Eclipta prostrata L, scientific name Ecliptaprostrata L, belongs to the annual herb of Asteraceae; green salt is the salt directly extracted from the salt lake and the salt made by drying in the salt field with the brine of the salt lake as raw material.

De-meshing the Zanthoxylum bungeanum refers to removing the core contained in the Zanthoxylum bungeanum.

The fixed-tooth dental membrane prepared by the above-mentioned preparation method.

The outer arc length of the above-mentioned dental membrane sticker is 11-17cm, the width is 1.0-1.5cm, and the outer arc radius is 10-15cm.

The application of the fixed dental membrane on the teeth.

The method of use of the present invention: take out two stickers during use, apply them on the upper and lower teeth respectively, remove the dental membrane stickers after 10-15 minutes, no need to rinse mouth, convenient to use, and can be used under any circumstances.

Beneficial effects of the present invention:

The tooth-fixing pellicle prepared by the present invention presents the traditional tooth-fixing formula in the form of a gel-type pellicle, which enhances the affinity with the teeth and is not easy to fall off. The dental membrane patch of the present invention can alleviate and cure gum swelling and periodontitis by direct application, can prevent periodontal disease after long-term use, has a better protective effect on gums, and achieves the effect of fixing teeth. It is a development for dental health care products. A new effective way is provided. The dental pellicle of the invention is easy to use, can be applied directly, and will not cause tooth loosening, and is especially the best choice for people with loose teeth and elderly people who need care.

Compared with toothpaste, mouthwash and other products sold in the existing market, the present invention has wide applicability, more pertinence, and is easy to carry; compared with existing toothache stickers, the present invention has strong affinity to teeth and is not easy to fall off , No need to gargle with water after use, more convenient to use; it provides a new and effective way for the development of dental health care products, does not add preservatives, and also meets the new pursuit of modern people. The inventive process is simple to operate and is suitable for industrial scale production.

Nutritional mechanism of the present invention is:

Green salt: salty and cold, can be used to sterilize, prevent tooth decay, treat bleeding of tongue and tongue, and toothache;

Gypsum: It can relieve muscle and clear away heat, eliminate restlessness and quench thirst, treat febrile disease with persistent fever, upset and coma, delirium, dementia, thirst and dry throat, lung heat and shortness of breath, spontaneous sweating due to heatstroke, stomach fire headache, toothache, heat toxin congestion Sheng, macule eruption;

Psoralen: has antibacterial and anti-inflammatory effects;

Zanthoxylum bungeanum: pungent in taste, hot in nature, has the effect of relieving toothache;

Angelica dahurica: It can cure headache, toothache, arthralgia and other pains;

Peppermint: pungent in taste, cool in nature, can dispel wind and dissipate heat, clear throat and improve eyesight;

Eclipta: sweet, sour, cool in nature, returns to the kidney and liver channels;

Fangfeng: It has the pharmacological effects of analgesia, sedation and anti-allergy;

Herba Asari: has another name called horse fairy grass, pungent, warm, returns lung, kidney meridian, is used for the treatment of toothache.

Ethyl maltol is a food additive, which can cover the bitter taste of traditional Chinese medicine, avoid mouth discomfort, and maintain a long-lasting fragrance effect.

The anti-caries properties of xylitol have the best effect among all sweeteners. Xylitol cannot be fermented and utilized by bacteria that produce dental caries in the oral cavity, and can inhibit the growth of streptococcus and the production of acid. Xylitol can not only prevent Dental caries, strengthen teeth, and can slow down the bitterness of traditional Chinese medicine.

Chitosan is the only alkaline polysaccharide that exists naturally. It has good film-forming properties and is non-allergic, non-irritating and non-toxic to teeth. Chitosan can also enhance the immunity of teeth to infections caused by bacteria and fungi. The growth of pathogenic bacteria can promote the healing of wounds around the gums, and it is a good material for the preparation of membranes.

detailed description

Example 1

According to the traditional solid teeth formula, weigh 5g of green salt, 5g of gypsum, 4g of psoralen, 1.5g of pepper, 1.5g of Angelica dahurica, 1.5g of mint, 2.5g of Eclipta, 2.5g of Fangfeng, 1.5g of Asarum, and weigh Good medicines are coarsely crushed to obtain solid tooth powder.

Zanthoxylum bungeanum needs to be removed, that is, the core contained in Zanthoxylum bungeanum is removed.

Accurately weigh 50g of solid tooth powder, put it into a medicated food bag for extraction, add water equivalent to 8 times the weight and heat to 100°C for hot extraction, perform solid-liquid separation after 15 minutes, and collect the filtrate; add equivalent to 6 Double the weight of water for the second hot extraction, after 15 minutes, conduct solid-liquid separation, collect the filtrate, combine the two extraction filtrates, cool, and centrifuge for 15 minutes at a speed of 3600r/min, take the supernatant and place it in a water bath at 100°C Concentrate, and the extraction filtrate is concentrated to a density of 900g/L to obtain a tan solid tooth traditional Chinese medicine extraction solution.

Preparation of chitosan solution: Weigh 30 g of chitosan and citric acid, dissolve in 1 L of water under heating and stirring to prepare a solution.

Take 50mL of solid tooth traditional Chinese medicine extract, add ethyl maltol, xylitol, chitosan solution, make ethyl maltol 0.20g/L extract, xylitol 500g/L extract, shell The polysaccharide solution was added in an amount of 3L/L extract; heated at 100°C while stirring to make it evenly mixed, sterilized by heating for 20 minutes, and placed under ultraviolet light to cool to obtain a solid tooth membrane solution. Pathogenic bacteria cannot be detected.

First prepare the dental membrane matrix: weigh 2 g of sodium carboxymethyl cellulose and 2 g of gelatin, and dissolve them in 1 L of water under heating and stirring to prepare a composite sol.

Secondly, prepare the dental membrane matrix with the health-care effect of tooth-fixing: under the condition of heating and stirring, mix the tooth-fixing dental membrane solution and the composite sol solution at a volume ratio of 8:1, and mix them evenly.

Finally, heat to 90°C, keep it for 30s, keep stirring, cool down to 75°C under aseptic conditions, inject it into the dental membrane model made by heating and blowing the hard packaging material with compressed air, and wait for the dental membrane to solidify and form into a soft colloid. Finally, the formed dental membrane is punched and sealed, and finally automatically cut into individual dental membranes. The dental membrane has a certain curvature, the outer arc length is 14cm, the width is 1.2cm, and the outer arc radius is 10cm.

Example 2

According to the traditional solid tooth formula, weigh 4.8g of green salt, 4.8g of gypsum, 3.8g of psoralen, 1.3g of pepper, 1.3g of Angelica dahurica, 1.3g of mint, 2.2g of Eclipta, 2.2g of Fangfeng, 1.2g of Asarum, Coarsely pulverize the weighed medicine to obtain solid tooth powder.

Note: Zanthoxylum bungeanum needs to be removed, that is, the core contained in Zanthoxylum bungeanum should be removed.

Accurately weigh 55g of solid tooth powder, put it into a medicated food bag for extraction, add water equivalent to 10 times the weight and heat it to 90°C for hot extraction, perform solid-liquid separation after 15 minutes, and collect the filtrate; add equivalent to 6 Double the weight of water for the second hot leaching, after 15 minutes of solid-liquid separation, collect the filtrate, combine the two leaching filtrates, cool, and centrifuge at a speed of 4000r/min for 10min, take the supernatant and place it in a water bath at 100°C. Concentrate, and concentrate the extraction filtrate to a density of 1100g/L to obtain a brown solid tooth traditional Chinese medicine extraction solution.

Preparation of chitosan solution: weigh 35g each of chitosan and citric acid, dissolve them in 1L of water under heating and stirring to prepare a solution.

Get solid teeth traditional Chinese medicine extract 55mL, add ethyl maltol, xylitol, chitosan solution, described ethyl maltol is 0.25g/L extract, xylitol is 550g/L extract, The chitosan solution was added in an amount of 3.5L/L extract; heated at 100°C while stirring to make it evenly mixed, heated and sterilized for 20 minutes, placed under ultraviolet light and cooled to obtain tooth-fixing dental membrane solution. Pathogenic bacteria cannot be detected.

First prepare the dental membrane matrix: weigh 1.5 g each of sodium carboxymethyl cellulose and gelatin, and dissolve them in 1 L of water under heating and stirring to prepare a composite sol.

Next, prepare the dental membrane matrix with the health-care effect of tooth-fixing: under the condition of heating and stirring, mix the tooth-fixing dental membrane solution and the composite sol solution at a volume ratio of 9:1.5, and mix them evenly.

Finally, heat to 100°C, keep it for 20s, keep stirring, cool down to 80°C under aseptic conditions, inject it into the dental membrane model made by heating and blowing the hard packaging material with compressed air, and wait for the dental membrane to solidify and form into a soft colloid After being shaped, the formed dental membrane is stamped and sealed, and finally cut into individual dental membranes automatically. The dental membrane has a certain curvature, the outer arc length is 17cm, the width is 1.5cm, and the outer arc radius is 15cm.

Example 3

According to the traditional solid teeth formula, weigh 5.2g of green salt, 5.2g of gypsum, 4.2g of psoralen, 1.7g of Zanthoxylum bungeanum, 1.7g of Angelica dahurica, 1.7g of mint, 2.9g of Eclipta, 2.9g of Fangfeng, 1.8g of Asarum, Coarsely pulverize the weighed medicine to obtain solid tooth powder.

Note: Zanthoxylum bungeanum needs to be removed, that is, the core contained in Zanthoxylum bungeanum should be removed.

Accurately weigh 45g of solid tooth powder, put it into a medicated food bag for leaching, add water equivalent to 6 times the weight and heat it to 110°C for hot leaching, perform solid-liquid separation after 15 minutes, and collect the filtrate; add 6 times the weight of Double the weight of water for the second hot extraction, after 15 minutes of solid-liquid separation, collect the filtrate, combine the two extraction filtrates, cool, and centrifuge at a speed of 3000r/min for 20min, take the supernatant and place it in a water bath at 100°C Concentrate, and the extraction filtrate is concentrated to a concentration of 900g/L to obtain a tan solid tooth traditional Chinese medicine extract.

Preparation of chitosan solution: Weigh each 25g of chitosan and citric acid, and dissolve them in 1L of water under heating and stirring to prepare a solution.

Get solid teeth traditional Chinese medicine extract 45mL, add ethyl maltol, xylitol, chitosan solution, described ethyl maltol is 0.15g/L extract, xylitol is 450g/L extract, The amount of chitosan solution added is 2.5L/L extract, heated at 110°C while stirring to make it evenly mixed, heated and sterilized for 15 minutes, placed under ultraviolet light and cooled to obtain tooth-fixing dental membrane solution. Pathogenic bacteria cannot be detected.

First prepare the dental membrane matrix: weigh 2.5 g each of sodium carboxymethyl cellulose and gelatin, and dissolve them in 1 L of water under heating and stirring to prepare a composite sol.

Secondly, prepare the dental membrane matrix with the health-care effect of tooth-fixing: under the condition of heating and stirring, mix the tooth-fixing dental membrane solution and the composite sol solution at a volume ratio of 6:0.5, and mix them evenly.

Finally, heat to 80°C, keep it for 40s, stir constantly, cool to 70°C under aseptic conditions, inject it into the dental membrane model made by heating and blowing the hard packaging material with compressed air, and wait for the dental membrane to solidify and form into a soft colloid After being shaped, the formed dental membrane is stamped and sealed, and finally cut into individual dental membranes automatically. The dental membrane has a certain curvature, the outer arc is 11 cm long, 1.0 cm wide, and the outer arc radius is 10 cm.

The above-mentioned embodiment is a preferred embodiment of the present invention, but the embodiment of the present invention is not limited by the above-mentioned embodiment, and those skilled in the art should understand that on the basis of the technical solution of the present invention, those skilled in the art do not need Various modifications or deformations that can be made with creative efforts are still within the protection scope of the present invention.

Claims (7)

1. a kind of preparation method of the solid teeth gel type dental pellicle that is convenient to use is characterized in that, comprises the following steps: adding ethyl maltol, xylitol, chitosan solution in the solid teeth Chinese medicine extract, To obtain the solid tooth membrane solution; dissolving sodium carboxymethyl cellulose and gelatin in water to make a composite sol solution; after mixing the solid tooth membrane solution and the composite sol solution evenly, forming a pre-film of the mixed solution; The components of the teeth-fixing traditional Chinese medicine are as follows in parts by weight: 4.8-5.2 parts of blue salt, 4.8-5.2 parts of gypsum, 3.8-4.2 parts of psoralen, 1.3-1.7 parts of Chinese prickly ash, 1.3-1.7 parts of Angelica dahurica, 1.3-5.2 parts of mint 1.7 parts, Eclipta 2.2-2.9 parts, Fangfeng 2.2-2.9 parts, Asarum 1.2-1.8 parts. 2. The preparation method according to claim 1, characterized in that it specifically comprises the following steps: (1) adding ethyl maltol, xylitol, Chitosan solution, after mixing evenly, place it on a water bath at 90-110°C for 20-40 minutes, heat and sterilize it for 20-40 minutes, then place it under ultraviolet radiation and cool it to room temperature to obtain tooth-fixing dental membrane solution, and the concentration of ethyl maltol is 0.15 -0.25g/L extract, the concentration of xylitol is 450-550g/L extract, the amount of chitosan solution added is 2.5-3.5L/L extract; (2) carboxymethyl cellulose Sodium and gelatin are dissolved in water to make a composite sol, and the concentration of the two substances is 1.5-2.5g/L; (3) The volume ratio of the solid tooth membrane solution to the composite sol is 6-9:0.5-1.5 Mix evenly, inject the mixed solution into the dental membrane model, punch and seal the molded dental membrane, and cut it into individual dental membrane stickers; the chitosan solution is an aqueous solution with chitosan and citric acid concentrations of 25-35g/L . 3. The preparation method according to claim 1 or 2, characterized in that, the preparation steps of the extract of the solid tooth traditional Chinese medicine are as follows: (1) crushing the components of the solid tooth traditional Chinese medicine to obtain solid tooth powder; (2) weighing Take 45-55g solid tooth powder, add water equivalent to 12-16 times the weight of solid tooth powder, heat to 90-110°C for hot extraction, 15-30min later carry out solid-liquid separation, collect the filtrate, cool it, and heat it at 3000- Centrifuge at 4000r/min for 10-20min, and take the supernatant; (3) Concentrate the supernatant in a 90-110°C water bath, and concentrate the leaching filtrate to a density of 900-1100g/L. 4. The preparation method according to claim 3, characterized in that, the preparation steps of the solid tooth traditional Chinese medicine extract are as follows: get 50g of solid tooth powder, put it into a medicated food bag for extraction, add an amount equivalent to solid tooth Heat 8 times the weight of the tooth powder to 100°C for hot leaching, 15 minutes later for solid-liquid separation, and collect the filtrate; add water equivalent to 6 times the weight of the solid tooth powder to the filter residue for secondary hot leaching, solid-liquid separation Finally, collect the filtrate, combine the two extraction filtrates, cool, and centrifuge at a speed of 3600r/min for 15min, place the supernatant in a water bath at 100°C for concentration, and concentrate the extraction filtrate to a density of 900-1100g/L . 5. The preparation method according to claim 2, characterized in that, the step (3) is specifically: under the condition of heating and stirring continuously, the solid tooth membrane solution and the composite sol solution are mixed at a volume ratio of 8:1, Mix evenly, heat to 90°C, keep for 30s, stir continuously, cool to 75°C under aseptic conditions, inject into the dental membrane model made by heating and blowing the hard packaging material with compressed air, and wait for the dental membrane to solidify and form After the soft colloid is formed, the formed dental membrane is punched and sealed, and finally automatically cut into individual dental membranes. 6. The tooth-fixing gel type dental membrane strip prepared by the preparation method described in any one of claims 1-5. 7. The tooth-fixing gel-type dental membrane according to claim 6, wherein the outer arc of the dental membrane is 11-17 cm long, 1.0-1.5 cm wide, and has an outer arc radius of 10-15 cm.