CN111557877A - Toothpaste containing centella extract and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of oral cleaning products, and in particular relates to a toothpaste containing centella asiatica extract and a preparation method thereof. The toothpaste containing Centella asiatica extract provided by the invention comprises the following components and their weight percentages: hydrated silica 20.0-28.0%, humectant 31.0-53.0%, sodium lauryl sulfate 2.0-3.0%, anti-inflammatory soothing agent 1.2～3.7%, essence 1.0～1.5%, xanthan gum 0.8～1.2%, cocamidopropyl betaine 0.2～0.5%, sodium saccharin 0.2～0.5%, preservative 0.2～0.5%, titanium dioxide 0.2～0.5% , Centella asiatica extract 0.1 ~ 0.3%, water 7.3 ~ 43.1%. The toothpaste containing the Centella asiatica extract provided by the invention is safe, mild, and non-irritating, and has the functions of antibacterial and anti-inflammatory, and can effectively relieve gingival swelling and pain, and relieve allergies.

Description

A kind of toothpaste containing Centella asiatica extract and preparation method thereof

technical field

The invention belongs to the technical field of oral cleaning products, and in particular relates to a toothpaste containing centella asiatica extract and a preparation method thereof.

Background technique

The oral cavity is one of the ways for pathogenic microorganisms to invade the human body. The temperature, humidity and food residues of the oral cavity are suitable for the growth and reproduction of microorganisms. Effective oral care keeps your mouth clean and prevents oral infections. Oral health has become one of the important indicators for the World Health Organization to evaluate the level of human health. Maintaining oral hygiene is a physiological need of human beings, and oral care is an inseparable part of body care. Common oral problems include: sore gums, tooth decay, mouth ulcers, bleeding gums, gingivitis, periodontitis, gum recession, and cementum loss. Dental health is very important to a person's overall health. There is a strong link between poor oral health and systemic diseases such as heart disease, diabetes and some respiratory diseases.

Toothpaste paste base is mainly composed of one or more combinations of glycerin, sorbitol, propylene glycol or polyethylene glycol as a wetting agent, sodium hydroxymethyl cellulose, hydroxyethyl cellulose, carrageenan or xanthan gum, etc. Used alone or in combination as a binder, sodium lauryl sulfate as a surfactant, calcium carbonate, aluminum hydroxide, silicon dioxide or calcium bicarbonate used alone or in combination as a friction agent, and a fragrance and deionized water composition . Sodium lauryl sulfate is an excellent anionic surfactant. As the most commonly used foaming agent in toothpaste, it is one of the important raw materials for toothpaste production. The role of cleaning and decontamination.

However, sodium lauryl sulfate can stimulate the oral cavity to a certain extent. In order to reduce the irritation, technicians generally reduce the amount of sodium lauryl sulfate or do not use sodium lauryl sulfate, or use foaming with milder performance. Agents (such as sodium lauroyl sarcosinate) to reduce irritation to the mouth. In recent years, with the increasing living standards of the public and the improvement of people's requirements for health, toothpastes that are safe, effective and have less side effects are favored by more and more consumers.

Plant extracts refer to biologically active substances that exist in plants and are extracted by physical or chemical methods. Different degrees of antibacterial and anti-inflammatory effects. Chinese patent CN 107184473B discloses a toothpaste containing saponin thorn extract, comprising the following components: 0.5-8 parts of saponin thorn extract; 10-30 parts of wetting agent; 15-45 parts of friction agent; foaming agent 0.5-1.5 part; binder 0.4-1.6 part; stabilizer 0.15-0.3 part; sweetener 0.2-0.8 part. In the invention, natural plant extracts such as saponin thorn extract are added, which have obvious antibacterial and anti-inflammatory effects, but the added foaming agent contains sodium lauryl sulfate, which is irritating to the oral cavity and has relatively stable stability. Poor, prone to delamination and other phenomena.

Therefore, it is necessary to develop a toothpaste containing natural plant extracts, which has functions such as antibacterial, anti-inflammatory, anti-allergy, and hemostasis in addition to the basic functions of toothpaste. At the same time, it is safe and mild, does not irritate the mouth, and has high stability.

SUMMARY OF THE INVENTION

In order to solve the problems existing in the prior art, the purpose of the present invention is to provide a toothpaste containing Centella asiatica extract and a preparation method thereof. The toothpaste containing the Centella asiatica extract provided by the invention is safe, mild, and non-irritating, and has the functions of antibacterial and anti-inflammatory, and can effectively relieve gingival swelling and pain, and relieve allergies.

The technical scheme of the present invention is:

A toothpaste containing Centella asiatica extract, comprising the following components and their weight percentages:

Hydrated silica 20.0-28.0%, humectant 31.0-53.0%, sodium lauryl sulfate 2.0-3.0%, anti-inflammatory soothing agent 1.2-3.7%, essence 1.0-1.5%, xanthan gum 0.8-1.2%, cocamide Propyl betaine 0.2-0.5%, sodium saccharin 0.2-0.5%, preservative 0.2-0.5%, titanium dioxide 0.2-0.5%, Centella asiatica extract 0.1-0.3%, water 7.3-43.1%.

Further, the toothpaste containing Centella asiatica extract is composed of the following components and their weight percentages: hydrated silica 22.0%, humectant 46.0%, sodium lauryl sulfate 2.5%, anti-inflammatory soothing agent 3.0%, Flavor 1.2%, Xanthan Gum 1.0%, Cocamidopropyl Betaine 0.4%, Sodium Saccharin 0.3%, Preservatives 0.3%, Titanium Dioxide 0.4%, Centella Asiatica Extract 0.2%, Water 22.7%.

Further, the wetting agent is composed of glycerol, sorbitol, and polyethylene glycol-8 in a weight ratio of 15-25:15-25:1-3.

Further, the wetting agent is composed of glycerol, sorbitol, and polyethylene glycol-8 in a weight ratio of 20:21:2.

Further, the anti-inflammatory soothing agent is composed of hyaluronic acid, potassium nitrate, and zinc citrate in a weight ratio of 1-2:10-30:1-5.

Further, the anti-inflammatory soothing agent is composed of hyaluronic acid, potassium nitrate, and zinc citrate in a weight ratio of 1.5:20:3.5.

Further, the preservative is sodium phenyl potassium.

Further, the preparation method of described Centella asiatica extract is as follows:

After crushing the Centella asiatica, add deionized water 4 to 8 times the volume of Centella asiatica, soak for 6 to 18 hours, then heat and boil for 1 to 3 hours, separate the medicinal liquid, and add 2 volume of medicinal dregs to the medicinal dregs. ~6 times of deionized water, continue to heat and boil for 1 to 3 hours, combine the two boiled medicinal liquids, filter, centrifuge, discard the precipitate, concentrate the supernatant, dry or freeze-dried to obtain snow grass extract.

In addition, the present invention also provides a method for preparing a toothpaste containing Centella asiatica extract, comprising the following steps:

S1, add anti-inflammatory soothing agent, sodium saccharin, Centella asiatica extract into water, stir until completely dissolved, and obtain mixture A for subsequent use;

S2, add xanthan gum and titanium dioxide to the wetting agent, stir until completely dissolved and dispersed, to obtain mixed solution B, for subsequent use;

S3. Add mixed solution B to mixed solution A, stir until uniform, then add hydrated silica, and finally add sodium lauryl sulfate, cocamidopropyl betaine, essence and preservative, stir until uniform, to obtain a paste Body, pumping, filling, and that's it.

Further, in the step S3, the vacuum degree during stirring is -0.082-0.10 Mpa, the stirring temperature is 38-42°C, and the stirring rate is 120-180 rpm.

The Centella asiatica extract added in the present invention is extracted from Centella asiatica. Centella asiatica is a plant of the Umbelliferae Centella asiatica. Because its leaves resemble a horseshoe or half a copper coin, it is also known as horseshoe grass, even money grass, etc. It is also called peppermint and ground money grass in some places. According to the "Compendium of Materia Medica", Centella asiatica is bitter, acrid, cold in nature, non-toxic, and returns to the liver, spleen, kidney, and stomach meridians. In addition, promoting blood circulation and removing blood stasis is also one of the important effects of Centella asiatica. It has obvious therapeutic effects on human congestion, swelling, pain and joint swelling. The chemical constituents of Centella asiatica mainly include triterpenes, flavonoids, polyacetylenes and volatile oils. Modern medical research shows that the total glucosides of Centella asiatica has significant physiological activity and can be used to treat depression, skin trauma, gastric ulcer, infectious hepatitis, skin diseases and epidemic cerebrospinal meningitis. Centella asiatica extracts have long exhibited a broad spectrum of biological activities, most importantly antioxidant, anti-inflammatory, antibacterial and anticancer activities. Centella asiatica extract stimulates fibroblast proliferation and activates the SMAD signaling pathway, thereby increasing the production of type I collagen and reducing the formation of stretch marks and inflammation. The terpenoids in Centella asiatica extract can significantly increase the content of collagen and cell laminin (fibronectin is widely involved in cell migration, adhesion, proliferation, hemostasis and skin tissue repair and other processes), and can stimulate and promote scarring. The production of mature type I collagen reduces the production of inflammatory responses.

At the same time, the anti-inflammatory and soothing agent added in the present invention, which is composed of hyaluronic acid, potassium nitrate, and zinc citrate in a certain proportion, has obvious anti-inflammatory and soothing effects, and can effectively relieve the oral cavity caused by sodium lauryl sulfate. When used in conjunction with the added Centella asiatica extract, it has obvious synergistic effects on gingival swelling and analgesia, and can reduce gingival swelling and pain.

The wetting agent added in the present invention, which is composed of glycerol, sorbitol and polyethylene glycol-8 in a certain proportion, is emulsified by the surfactant sodium lauryl sulfate and stably exists in the colloid system. The inventor unexpectedly found that when a certain amount of polyethylene glycol-8 is added to the wetting agent, sodium lauryl sulfate and the wetting agent can produce a certain adsorption and emulsifying effect, and at the same time synergize with the added xanthan gum, so that the The components in the toothpaste are more stable, and the phenomenon of solid-liquid separation is not easy to occur, which effectively solves the phenomenon that the toothpaste is prone to water out, thickening, and dull appearance during the storage process.

Compared with the prior art, the toothpaste containing Centella asiatica extract provided by the present invention has the following advantages:

(1) The toothpaste containing Centella asiatica extract provided by the present invention has the effect of anti-inflammatory and alleviating gingival swelling and pain. The added anti-allergic soothing agent and Centella asiatica extract synergistically play a major role in reducing swelling and analgesia, and can effectively relieve gingival swelling and pain, and relieve allergy.

(2) The toothpaste containing the Centella asiatica extract provided by the present invention is safe, mild, non-irritating, and has high stability, effectively solving the phenomenon that the toothpaste is prone to water out, thickening, and dull appearance during storage. .

Detailed ways

The present invention will be further described below through the description of the specific embodiments, but this is not a limitation of the present invention. Those skilled in the art can make various modifications or improvements according to the basic idea of the present invention, but as long as they do not depart from the basic idea of the present invention The ideas are all within the protection scope of the present invention.

Among them, the reagents used in the present invention are all commonly used reagents, which can be purchased from conventional reagent production and sales companies.

Embodiment 1 A kind of toothpaste containing Centella asiatica extract

The toothpaste containing Centella asiatica extract is composed of the following components and their weight percentages: hydrated silica 20.0%, humectant 31.0%, sodium lauryl sulfate 2.0%, anti-inflammatory soothing agent 1.2%, essence 1.0% , Xanthan Gum 0.8%, Cocamidopropyl Betaine 0.2%, Sodium Saccharin 0.2%, Sodium Phenyl Potassium 0.2%, Titanium Dioxide 0.2%, Centella Asiatica Extract 0.1%, Water 43.1%.

The wetting agent is composed of glycerol, sorbitol and polyethylene glycol-8 in a weight ratio of 15:25:3.

The anti-inflammatory soothing agent is composed of hyaluronic acid, potassium nitrate and zinc citrate in a weight ratio of 1:30:5.

The preparation method of described Centella asiatica extract is as follows:

After crushing the Centella asiatica, add deionized water with 4 times the volume of Centella asiatica, soak for 6 hours, then heat and boil for 1 hour, separate the medicinal liquid, and add deionized water with 2 times the volume of the medicinal dregs to the medicinal dregs. Continue to heat and boil for 1 hour, combine the two boiled medicinal liquids, filter, centrifuge, discard the precipitate, concentrate the supernatant, dry or freeze-dried to obtain Centella asiatica extract.

The described preparation method of the toothpaste containing Centella asiatica extract, comprises the steps:

S1, add anti-inflammatory soothing agent, sodium saccharin, Centella asiatica extract into water, stir until completely dissolved, and obtain mixture A for subsequent use;

S2, add xanthan gum and titanium dioxide to the wetting agent, stir until completely dissolved and dispersed, to obtain mixed solution B, for subsequent use;

S3, add mixed solution B to mixed solution A, stir until uniform, then add hydrated silica, and finally add sodium lauryl sulfate, cocamidopropyl betaine, essence and sodium benzoate, stir until uniform, to obtain paste Body, pumping, filling, and that's it.

In the step S3, the vacuum degree during stirring was -0.082Mpa, the stirring temperature was 38°C, and the stirring rate was 120 rpm.

Embodiment 2 A kind of toothpaste containing Centella asiatica extract

The toothpaste containing Centella asiatica extract is composed of the following components and their weight percentages: hydrated silica 22.0%, humectant 46.0%, sodium lauryl sulfate 2.5%, anti-inflammatory soothing agent 3.0%, essence 1.2% , Xanthan Gum 1.0%, Cocamidopropyl Betaine 0.4%, Sodium Saccharin 0.3%, Sodium Phenyl Potassium 0.3%, Titanium Dioxide 0.4%, Centella Asiatica Extract 0.2%, Water 22.7%.

The wetting agent is composed of glycerol, sorbitol and polyethylene glycol-8 in a weight ratio of 20:21:2.

The anti-inflammatory soothing agent is composed of hyaluronic acid, potassium nitrate and zinc citrate in a weight ratio of 1.5:20:3.5.

The preparation method of described Centella asiatica extract is as follows:

After crushing the Centella asiatica, add deionized water 6 times the volume of Centella asiatica, soak for 12 hours, then heat and boil for 2 hours, separate the medicinal liquid, and add 4 times the volume of deionized water to the medicinal dregs. Continue to heat and boil for 2 hours, combine the two boiled medicinal liquids, filter, centrifuge, discard the precipitate, concentrate the supernatant, dry or freeze-dried to obtain Centella asiatica extract.

The described preparation method of the toothpaste containing Centella asiatica extract, comprises the steps:

S1, add anti-inflammatory soothing agent, sodium saccharin, Centella asiatica extract into water, stir until completely dissolved, and obtain mixture A for subsequent use;

S2, add xanthan gum and titanium dioxide to the wetting agent, stir until completely dissolved and dispersed, to obtain mixed solution B, for subsequent use;

S3, add mixed solution B to mixed solution A, stir until uniform, then add hydrated silica, and finally add sodium lauryl sulfate, cocamidopropyl betaine, essence and sodium benzoate, stir until uniform, to obtain paste Body, pumping, filling, and that's it.

In the step S3, the vacuum degree during stirring is -0.05Mpa, the stirring temperature is 40°C, and the stirring speed is 150 rpm.

Embodiment 3 A kind of toothpaste containing Centella asiatica extract

The toothpaste containing Centella asiatica extract is composed of the following components and their weight percentages: hydrated silica 28.0%, humectant 53.0%, sodium lauryl sulfate 3.0%, anti-inflammatory soothing agent 3.7%, essence 1.5% , Xanthan Gum 1.2%, Cocamidopropyl Betaine 0.5%, Sodium Saccharin 0.5%, Sodium Phenyl Potassium 0.5%, Titanium Dioxide 0.5%, Centella Asiatica Extract 0.3%, Water 7.3%.

The wetting agent is composed of glycerol, sorbitol and polyethylene glycol-8 in a weight ratio of 25:15:1.

The anti-inflammatory and soothing agent is composed of hyaluronic acid, potassium nitrate, and zinc citrate in a weight ratio of 2:10:1.

The preparation method of described Centella asiatica extract is as follows:

After crushing the Centella asiatica, add deionized water 8 times the volume of Centella asiatica, soak for 18 hours, then heat and boil for 3 hours, separate the medicinal liquid, add 6 times the volume of deionized water to the medicinal residues, Continue to heat and boil for 3 hours, combine the two boiled medicinal liquids, filter, centrifuge, discard the precipitate, concentrate the supernatant, dry or freeze-dried to obtain Centella asiatica extract.

The described preparation method of the toothpaste containing Centella asiatica extract, comprises the steps:

S1, add anti-inflammatory soothing agent, sodium saccharin, Centella asiatica extract into water, stir until completely dissolved, and obtain mixture A for subsequent use;

S2, add xanthan gum and titanium dioxide to the wetting agent, stir until completely dissolved and dispersed, to obtain mixed solution B, for subsequent use;

S3, add mixed solution B to mixed solution A, stir until uniform, then add hydrated silica, and finally add sodium lauryl sulfate, cocamidopropyl betaine, essence and sodium benzoate, stir until uniform, to obtain paste Body, pumping, filling, and that's it.

In the step S3, the vacuum degree during stirring is 0.10Mpa, the stirring temperature is 42°C, and the stirring speed is 180 rpm.

Comparative Example 1 A toothpaste containing Centella asiatica extract

The toothpaste containing Centella asiatica extract is composed of the following components and their weight percentages: hydrated silica 22.0%, humectant 46.0%, sodium lauryl sulfate 2.5%, anti-inflammatory soothing agent 3.0%, essence 1.2% , Xanthan Gum 1.0%, Cocamidopropyl Betaine 0.4%, Sodium Saccharin 0.3%, Sodium Phenyl Potassium 0.3%, Titanium Dioxide 0.4%, Centella Asiatica Extract 0.2%, Water 22.7%.

The wetting agent is composed of glycerol, sorbitol and polyethylene glycol-8 in a weight ratio of 20:21:2.

The anti-inflammatory soothing agent is composed of potassium nitrate and zinc citrate in a weight ratio of 20:3.5.

The preparation method of the Centella asiatica extract is similar to that of Example 2.

The preparation method of the toothpaste containing Centella asiatica extract is similar to Example 2.

The difference from Example 2 is that no hyaluronic acid is added to the anti-inflammatory soothing agent.

Comparative Example 2 A toothpaste containing Centella asiatica extract

The toothpaste containing Centella asiatica extract is composed of the following components and their weight percentages: hydrated silica 22.0%, humectant 46.0%, sodium lauryl sulfate 2.5%, anti-inflammatory soothing agent 3.0%, essence 1.2% , Xanthan Gum 1.0%, Cocamidopropyl Betaine 0.4%, Sodium Saccharin 0.3%, Sodium Phenyl Potassium 0.3%, Titanium Dioxide 0.4%, Centella Asiatica Extract 0.2%, Water 22.7%.

The wetting agent is composed of glycerol, sorbitol and polyethylene glycol-8 in a weight ratio of 20:21:2.

The anti-inflammatory soothing agent is composed of hyaluronic acid and potassium nitrate in a weight ratio of 1.5:20.

The preparation method of the Centella asiatica extract is similar to that of Example 2.

The preparation method of the toothpaste containing Centella asiatica extract is similar to Example 2.

The difference from Example 2 is that no zinc citrate is added to the anti-inflammatory soothing agent.

Comparative Example 3 A toothpaste containing Centella asiatica extract

The toothpaste containing Centella asiatica extract is composed of the following components and their weight percentages: hydrated silica 22.0%, humectant 46.0%, sodium lauryl sulfate 2.5%, anti-inflammatory soothing agent 3.0%, essence 1.2% , Xanthan Gum 1.0%, Cocamidopropyl Betaine 0.4%, Sodium Saccharin 0.3%, Sodium Phenyl Potassium 0.3%, Titanium Dioxide 0.4%, Centella Asiatica Extract 0.2%, Water 22.7%.

The wetting agent is composed of glycerol, sorbitol and polyethylene glycol-8 in a weight ratio of 20:21:2.

The anti-inflammatory soothing agent is composed of hyaluronic acid, potassium nitrate and zinc citrate in a weight ratio of 1:1:1.

The preparation method of the Centella asiatica extract is similar to that of Example 2.

The preparation method of the toothpaste containing Centella asiatica extract is similar to Example 2.

The difference from Example 2 is that the anti-inflammatory soothing agent is composed of hyaluronic acid, potassium nitrate, and zinc citrate in a weight ratio of 1:1:1.

Comparative Example 4 A toothpaste containing Centella asiatica extract

The toothpaste containing Centella asiatica extract is composed of the following components and their weight percentages: hydrated silica 22.0%, humectant 46.0%, sodium lauryl sulfate 2.5%, anti-inflammatory soothing agent 3.0%, essence 1.2% , Xanthan Gum 1.0%, Cocamidopropyl Betaine 0.4%, Sodium Saccharin 0.3%, Sodium Phenyl Potassium 0.3%, Titanium Dioxide 0.4%, Centella Asiatica Extract 0.2%, Water 22.7%.

The wetting agent is composed of glycerol and sorbitol in a weight ratio of 20:21.

The anti-inflammatory soothing agent is composed of hyaluronic acid, potassium nitrate and zinc citrate in a weight ratio of 1.5:20:3.5.

The preparation method of the Centella asiatica extract is similar to that of Example 2.

The preparation method of the toothpaste containing Centella asiatica extract is similar to Example 2.

The difference from Example 2 is that polyethylene glycol-8 is not added to the wetting agent.

Test example 1. Experimental study on anti-inflammatory effect

1. Test materials: toothpastes containing Centella asiatica extract prepared in Examples 1-3 and Comparative Examples 1-4.

2. Test method: After 3 days of adaptive feeding, mice were randomly divided into 8 groups according to gender and body weight.

Examples 1-3 groups, comparative examples 1-4 groups, blank control group, 10 in each group. Before the inflammation, the abdominal depilatory agent sodium sulfide was used to remove the hair of the mice, and the toothpastes containing the Centella asiatica extract prepared in Examples 1-3 and Comparative Examples 1-4 were respectively applied, and the application area was 2cm×1cm (about 10% of the total body surface area). %), the amount of toothpaste was 0.5 g/cm ² , and a glass rod was used for local application. The test toothpaste was evenly applied to the shaved area, once a day; the blank control group was applied with toothpaste base; The front and back sides of the left ear of the mice were coated with 0.02 ml of 100% xylene, and the mice were killed by cervical dislocation every 4 hours. = left ear piece weight - right ear piece weight.

3. Test results

The test results are shown in Table 1.

Table 1 Effects on inflammation caused by ear swelling in mice

group number of animals Swelling degree (mg) Example 1 group 10 14.7±5.02^* Example 2 group 10 14.1±4.79^** Example 3 groups 10 15.2±4.36 Comparative example 1 group 10 22.9±2.98^* Comparative example 2 groups 10 23.4±6.71 Comparative example 3 groups 10 21.2±5.26^** Comparative example 4 groups 10 16.3±2.64^* Blank control group 10 26.3±4.75

It can be seen from Table 1: Compared with the blank control group, the toothpastes containing the Centella asiatica extract prepared by the Example 1 group, the Example 2 group and the Example 3 group can obviously reduce the swelling of the auricle caused by xylene in mice. , has anti-inflammatory effect, among which the second group of embodiment has the best effect, which is the best embodiment of the present invention. However, the toothpaste containing Centella asiatica prepared in Comparative Examples 1-3 (when the components of the anti-sensitivity and soothing agent added in the present invention were changed) had significantly worse effect on reducing the swelling of the auricle caused by xylene in mice than Test results of groups 1-3. It can be seen that the anti-allergic and soothing agent provided by the present invention has all the components indispensable, and has obvious synergistic effect with the Centella asiatica extract, and has good anti-inflammatory and alleviating gingival swelling and pain effects.

Test example 2. Stability test

1. Test materials: toothpastes containing Centella asiatica extract prepared in Examples 1-3 and Comparative Examples 1-4.

2. Test method: The toothpastes containing Centella asiatica extract prepared in Examples 1-3 and Comparative Examples 1-4 were packed into

Put it into the toothpaste tube for preservation, and store it at 5℃, room temperature and 40℃ for three months, and then observe the toothpaste.

The preservation of ointment.

3. Test results

The test results are shown in Table 2.

The stability investigation result of each toothpaste of table 2

As can be seen from Table 2: the toothpaste containing the Centella asiatica extract prepared by the groups of Examples 1-3 was stored for three months at 5 ° C, room temperature and 40 ° C, and the toothpaste was uniform and fine, and there was no solid-liquid separation phenomenon. The toothpaste containing the Centella asiatica extract prepared by the invention has good stability. In Comparative Example 4, after the components in the moisturizing agent were changed, the toothpaste could not be stored stably, and after standing for a certain period of time, phenomena such as the separation of the paste into layers and water separation would occur.

The above-mentioned embodiments merely illustrate the principles and effects of the present invention, but are not intended to limit the present invention. Anyone skilled in the art can modify or change the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or changes made by those with ordinary knowledge in the technical field without departing from the spirit and technical idea disclosed in the present invention should still be covered by the claims of the present invention.

Claims (10)

1. The toothpaste containing the centella asiatica extract is characterized by comprising the following components in percentage by weight: 20.0-28.0% of hydrated silica, 31.0-53.0% of wetting agent, 2.0-3.0% of sodium lauryl sulfate, 1.2-3.7% of anti-inflammatory soothing agent, 1.0-1.5% of essence, 0.8-1.2% of xanthan gum, 0.2-0.5% of cocamidopropyl betaine, 0.2-0.5% of sodium saccharin, 0.2-0.5% of preservative, 0.2-0.5% of titanium dioxide, 0.1-0.3% of centella asiatica extract and 7.3-43.1% of water.

2. The toothpaste of claim 1, comprising centella asiatica extract, which comprises the following components in percentage by weight: 22.0% of hydrated silica, 46.0% of wetting agent, 2.5% of sodium lauryl sulfate, 3.0% of anti-inflammatory soothing agent, 1.2% of essence, 1.0% of xanthan gum, 0.4% of cocamidopropyl betaine, 0.3% of sodium saccharin, 0.3% of preservative, 0.4% of titanium dioxide, 0.2% of centella extract and 22.7% of water.

3. The toothpaste containing centella asiatica extract according to claim 1 or 2, wherein the humectant comprises glycerin, sorbitol, and polyethylene glycol-8 at a weight ratio of 15-25: 1-3.

4. The toothpaste of claim 3, wherein said humectant consists of glycerin, sorbitol, polyethylene glycol-8 in a weight ratio of 20:21: 2.

5. The toothpaste containing centella asiatica extract according to claim 1 or 2, wherein the anti-inflammatory soothing agent comprises hyaluronic acid, potassium nitrate and zinc citrate at a weight ratio of 1-2: 10-30: 1-5.

6. The toothpaste of claim 5, wherein said anti-inflammatory soothing agent comprises hyaluronic acid, potassium nitrate, and zinc citrate in a weight ratio of 1.5:20: 3.5.

7. The toothpaste containing centella asiatica extract according to claim 1 or 2, wherein said preservative is sodium benzoate.

8. The toothpaste containing centella asiatica extract according to claim 1 or 2, wherein the centella asiatica extract is prepared by the following method:

crushing centella, adding deionized water with the volume 4-8 times that of the centella, soaking for 6-18 hours, heating and boiling for 1-3 hours, separating liquid medicine, adding deionized water with the volume 2-6 times that of medicine residues into the medicine residues, continuously heating and boiling for 1-3 hours, combining the liquid medicines after two times of boiling, filtering, centrifuging, discarding precipitates, concentrating supernate, drying or freeze-drying to obtain the centella extract.

9. A process for the preparation of a toothpaste containing an extract of centella asiatica according to any one of claims 1 to 8, comprising the following steps:

s1, adding the anti-inflammatory soothing agent, the saccharin sodium and the centella asiatica extract into water, and stirring until the components are completely dissolved to obtain a mixed solution A for later use;

s2, adding xanthan gum and titanium dioxide into the wetting agent, and stirring until complete dissolution and dispersion are achieved to obtain a mixed solution B for later use;

s3, adding the mixed solution B into the mixed solution A, stirring uniformly, adding hydrated silica, adding sodium lauryl sulfate, cocamidopropyl betaine, essence and preservative, stirring uniformly to obtain paste, pumping, and packaging.

10. The method of claim 9, wherein the stirring in step S3 is performed under a vacuum of-0.082-0.10 MPa, at a temperature of 38-42 ℃, and at a speed of 120-180 rpm.