CN103947875B - A kind of Chinese medicine feed additive and application thereof - Google Patents

Abstract

The present invention proposes a traditional Chinese medicine feed additive and its application. Schisandra chinensis, Shouwu, Chinese yam, cocklebur, epimedium, licorice, forsythia, dodder, kelp, and privet privet are composed according to a certain proportion; the preparation method is that the above-mentioned traditional Chinese medicines are dried and pulverized into traditional Chinese medicine The particle size is less than 10μm, and it is mixed. The feed additive of the invention has dual functions of medicine and nutrition, not only can directly improve the immune resistance of laying hens, but also can improve the production performance of laying hens, effectively increase egg production rate and improve egg quality.

Description

A kind of traditional Chinese medicine feed additive and its application

technical field

The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine feed additive and its application.

Background technique

As the main source of animal protein, eggs are particularly important in people's daily life. Therefore, how to increase egg production rate, how to improve the disease resistance of laying hens, and how to improve egg quality and feed conversion rate in laying hens are very important. It is particularly important, however, in the prior art, chemical agents and antibiotics are mostly used to achieve the above-mentioned purpose.

With the improvement of people's living standards, people begin to have higher requirements for food, and they are more repulsed by the use of chemical agents and antibiotics to raise livestock and poultry. Natural products such as native eggs are increasingly favored by people. Therefore, how to use traditional Chinese medicine It is particularly necessary to improve the egg production and egg quality of laying hens, but this field is still being explored.

Contents of the invention

In order to solve the problems in the above-mentioned prior art, the purpose of the invention is to propose a Chinese medicine feed additive.

Another object of the present invention is the application of a feed additive in increasing egg production rate and improving egg quality.

To achieve the above object, the technical solution of the present invention is:

A traditional Chinese medicine feed additive, which is composed of Motherwort, Prunella vulgaris, Houttuynia cordata, Astragalus, Codonopsis pilosula, honeysuckle, tea leaves, Rumex pasture, mulberry leaves, angelica, medical stone, divine comedy, tangerine peel, schisandra, Shouwu, yam, Cocklebur, epimedium, licorice, forsythia, dodder, kelp, privet privet are composed in a certain proportion;

The preparation method is as follows: the above-mentioned traditional Chinese medicine is dried and pulverized by superfine pulverization technology until the particle size of the traditional Chinese medicine is less than 10 μm, and then mixed.

Further, the traditional Chinese medicine feed additive is made of the following raw materials of Chinese medicinal materials in parts by weight: 3-5 parts of Motherwort, 3-5 parts of Prunella vulgaris, 1-3 parts of Houttuynia cordata, 10-15 parts of Astragalus membranaceus, 5-10 parts of Codonopsis pilosula 1-3 parts of honeysuckle, 10-15 parts of tea leaves, 15-20 parts of Rumex grass, 10-15 parts of mulberry leaves, 3-5 parts of angelica, 3-5 parts of cocklebur, 1-3 parts of medical stone 1-3 parts of Divine Comedy, 5-10 parts of Chenpi, 1-3 parts of Schisandra, 1-3 parts of Shouwu, 3-5 parts of Chinese Yam, 3-5 parts of Epimedium, 1-5 parts of Licorice, 3 parts of Forsythia —5 parts, 1-3 parts of dodder, 1-3 parts of kelp, 1-3 parts of Ligustrum lucidum;

The preparation method is that the above-mentioned traditional Chinese medicines are mixed in proportion and dried in the sun, and then pulverized by superfine pulverization technology until the particle size of the traditional Chinese medicines is less than 10 μm, and then mixed.

Furthermore, the above-mentioned traditional Chinese medicine feed additive is used in improving the production performance of laying hens, effectively increasing egg production rate and improving egg quality.

According to the physiological characteristics, nutritional needs, and production rules of laying hens, this component pays attention to the conditional compatibility of 18 anti and 19 fear in traditional Chinese medicine, and also pays attention to the synergy among nutrients such as vitamins, trace elements, and amino acids in traditional Chinese medicine. Anti-inflammatory, the formula has pharmacological effects such as invigorating the spleen and removing dampness, nourishing blood and nourishing qi, clearing heat and detoxifying, warming the kidney and helping yang, calming the nerves, regulating the balance of yin and yang in the body, and enhancing the body's immunity.

Compared with the prior art, the beneficial effects of the present invention are:

The feed additive of the invention has dual functions of medicine and nutrition, not only can directly improve the immune resistance of laying hens, but also can improve the production performance of laying hens, effectively increase egg production rate and improve egg quality. For the first time in this project, a variety of traditional Chinese medicines with exact effects are scientifically and rationally combined, so that the overall efficacy is greatly enhanced, and the cost is greatly reduced, so that the cost of adding this technical product to the feed is lower than that of antibiotics and some chemical medicines. Feed additives are better than antibiotics and other chemical feed additives in improving the resistance of laying hens, egg production rate and egg quality, and feed conversion rate. No drug resistance, high market acceptance, low promotion difficulty, and good application and promotion value. The promotion of this project can effectively reduce the cost of chicken farmers. Especially in the case of high incidence of bird flu in recent years, this feed additive can effectively enhance the resistance of chickens and reduce the chance of being infected with bird flu and other plagues. At the same time, this feed additive can significantly reduce the cholesterol content in eggs, reduce heavy metal residues in eggs, increase the content of omega-3 fatty acids, VE and VA and other nutrients in eggs, and meet the needs of contemporary people for a healthy diet. Guaranteed food safety and promoted consumption. In addition, the feed additive can reduce the feces excretion of laying hens, protect the environment, and has good economic and social benefits.

detailed description

The technical solution of the present invention is described in further detail below in conjunction with specific embodiments:

Example 1:

A traditional Chinese medicine feed additive, made from the following raw materials of Chinese medicinal materials in parts by weight: 3 parts of motherwort, 5 parts of Prunella vulgaris, 3 parts of Houttuynia cordata, 10 parts of astragalus, 10 parts of Codonopsis pilosula, 1 part of honeysuckle, 15 parts of tea leaves, 20 parts of Kesi pasture, 10 parts of mulberry leaves, 3 parts of angelica, 3 parts of cocklebur, 3 parts of medical stone, 1 part of Shenqu, 5 parts of tangerine peel, 3 parts of schisandra, 1 part of Shouwu, 5 parts of yam, epimedium 3 parts, 5 parts of licorice, 3 parts of forsythia, 2 parts of dodder, 2 parts of kelp, 1 part of privet fruit;

The preparation method is that the above-mentioned traditional Chinese medicines are mixed in proportion and dried in the sun, and then pulverized by superfine pulverization technology until the particle size of the traditional Chinese medicines is less than 10 μm, and then mixed.

Example 2:

A traditional Chinese medicine feed additive, made from the following raw materials of Chinese medicinal materials in parts by weight: 5 parts of motherwort, 3 parts of Prunella vulgaris, 1 part of Houttuynia cordata, 15 parts of astragalus, 5 parts of Codonopsis pilosula, 3 parts of honeysuckle, 10 parts of tea leaves, 15 parts of chrysanthemum grass, 15 parts of mulberry leaves, 5 parts of angelica, 5 parts of cocklebur, 1 part of medical stone, 3 parts of divine music, 10 parts of tangerine peel, 1 part of schisandra, 3 parts of Shouwu, 3 parts of yam, epimedium 5 parts, 1 part of licorice, 5 parts of forsythia, 1 part of dodder, 3 parts of kelp, 3 parts of privet fruit;

The preparation method is as in Example 1.

Example 3:

A traditional Chinese medicine feed additive, made from the following raw materials of Chinese medicinal materials in parts by weight: 4 parts of Motherwort, 4 parts of Prunella vulgaris, 2 parts of Houttuynia cordata, 10 parts of Astragalus membranaceus, 7 parts of Codonopsis pilosula, 3 parts of honeysuckle, 15 parts of tea leaves, 15 parts of grass, 12 parts of mulberry leaves, 3 parts of angelica, 4 parts of cocklebur, 3 parts of medical stone, 2 parts of divine music, 5 parts of tangerine peel, 3 parts of schisandra, 3 parts of Shouwu, 5 parts of yam, epimedium 5 parts, 3 parts of licorice, 4 parts of forsythia, 1 part of dodder, 1 part of kelp, 2 parts of privet fruit;

The preparation method is as in Example 1.

Example 4:

A traditional Chinese medicine feed additive, made from the following raw materials of Chinese medicinal materials in parts by weight: 5 parts of motherwort, 5 parts of Prunella vulgaris, 3 parts of Houttuynia cordata, 13 parts of astragalus, 8 parts of Codonopsis pilosula, 4 parts of honeysuckle, 12 parts of tea leaves, 13 parts of grass, 13 parts of mulberry leaves, 2 parts of angelica, 5 parts of cocklebur, 2 parts of medical stone, 1 part of Shenqu, 5 parts of tangerine peel, 3 parts of schisandra, 3 parts of Shouwu, 5 parts of yam, epimedium 5 parts, 3 parts of licorice, 4 parts of forsythia, 1 part of dodder, 1 part of kelp, 2 parts of privet fruit;

The preparation method is as in Example 1.

Test example:

1000 30-week-old Roman brown-shell hens with similar shape, good physical condition and basically the same body weight were selected and randomly divided into five groups with 200 chickens in each group. The first group was the control group (CK), the second, third, Groups four and five are test groups, represented by A, B, C, and D respectively. The control group was only fed the basal ration, and the test group A, test group B, test group C, and test group D added 0.5% of Example 1, 1% of Example 2, and 1.5% of Example 3 on the basis of feeding the basal ration, respectively. , the Chinese medicine feed additive of 2% embodiment 4.

Basic ration

Based on the feed nutrition standards for laying hens, the composition of the basic diet (unit: %): corn 62.2, bran 5.5, soybean meal 12, stone powder 8.3, protein meal 1.2, rapeseed meal 3, fish meal 4, meat and bone meal 2.16, salt 0.3, Methionine 0.12, Lysine 0.22, Rice Bran 1.

Feeding management

The test was carried out at the chicken farm in Xishagang Village, Xipingluo Township, Huixian City from April to May 2012. There was a 7-day pre-test period before the start of the test. Insects, epidemic prevention, weighing, grouping, numbering, recording. During the pre-test period, the basal diet was fed for 7 days. On the basis of the basal diet, compound Chinese medicine feed additives were added, and the amount added gradually increased from less to more. To the beginning of the trial period. Add to the normal amount. After 7 days of pre-test, enter the formal feeding test of 42 days. During the test period, they were managed by special personnel, free to eat, provided enough drinking water, and kept the chicken house dry and hygienic. Feed regularly at 6.00, 11.00, and 17.00 every day, weigh the remaining feed before feeding, and count the daily feed consumption. At 9.00 and 15.00, the temperature in the chicken house was recorded, and at 10.00 and 16.00, eggs were collected regularly. Monitor the health status of chickens in real time, and record the situation of dead chickens, and carry out regular routine disinfection in the chicken house. The rest are carried out in accordance with the routine management of chicken coops. The experiment started on April 1st and ended on May 19th.

Observation index

Record the egg production, the number of broken eggs, the number of soft eggs, and the number of deformed eggs, and calculate the egg production rate and feed-to-egg ratio. Egg weight, egg yolk color, Haugh unit and other indicators were measured by multifunctional egg quality tester EMT-5200; eggshell color was measured by eggshell color tester QCR; egg shape index was measured by FHK egg shape index tester; eggshell thickness Measured with SANOVO eggshell thickness tester; egg yolk ratio is the ratio of egg yolk to egg weight.

Egg Quality Determination

(1) After the end of the test period, 20 eggs from each of the test groups A, B, C, D and the control group were taken, marked and stored in cold storage. After the test, the five groups of eggs were tested for nutritional components by HPLC method. (2) Take 20 eggs from the test groups A, B, C, D and the control group to determine the content of heavy metals and antibiotics by atomic absorption spectrometer flame method.

Determination of immune indicators

Fasting for 20 hours after the test. 20 chickens were randomly selected for each treatment group, a total of 100 chickens. 8mL of blood was collected by cutting the neck, mixed with heparin sodium tube and stored at low temperature (4°C), centrifuged at 35000r/min for 10min, and the supernatant (plasma) was stored at -20°C for testing. Determination of NO (nitric oxide), NOS (nitric oxide synthase) content, iNOS (inducible nitric oxide synthase) and IgG (immunoglobulin G) by ELISA kit double-antibody two-step sandwich enzyme-linked immunosorbent assay active.

Statistical Analysis

The measurement results were analyzed by variance analysis and LSD multiple comparisons using SPSS 19.0 software, and expressed as mean ± standard error.

test results

Changes in the appearance of laying hens

After 49 days of experimentation, the laying hens of test groups A, B, C, and D were basically plump and bright in feathers, with bright eyes, standing upright, breathing without opening their mouths, bright red crowns, shiny chicken claw scales, and strong movements. No drooling; about half of the laying hens in the control group had dull eyes, unsteady standing, swollen eyelids, mouth breathing, uneven feather color, dark purple crown, weak movement, red spots on the anus, and drooling.

Effects of Traditional Chinese Medicine Feed Additives on Laying Hen Plasma Immune Indexes

Table 1 shows the effect of traditional Chinese medicine feed additives on laying hens' plasma immune indexes. It can be seen from Table 1 that compared with the control group, the four groups A, B, C, and D all increased the plasma IgG, NO content, and the activity of NOS and iNOS, among which group D had the best effect. Its IgG content reached 53.31μg/L, which was 22.05% higher than that of the control group, and the difference reached a very significant level (P<0.01). The NO content reached 12.06μmol/L, which was 29.12% higher than that in the control group, and the difference reached a very significant level (P<0.01). The NOS activity reached 4.66μmol/L, which was 14.50% higher than that in the control group, and the difference was extremely significant (P<0.01). The activity of iNOS reached 10.76IU/L, an increase of 7.39% compared with the control group, the difference was not significant (P>0.05).

Table 1 Effects of traditional Chinese medicine feed additives in laying hen feed on plasma immune indexes of laying hens

Many traditional Chinese medicines contain antibacterial, antibacterial, and bactericidal substances, immune active substances, substances that increase enzyme activity, organic acids, and substances that detoxify and promote toxin excretion, etc., which can stimulate animal growth, improve animal immunity and disease resistance, and maintain animal health. The normal balance of the internal environment ensures the healthy development of animals. Can promote the development of immune organs and antibody production. Activate lymphocytes and improve the immune function of the body. Stimulate the function of macrophages and T cells, so as to achieve antibacterial and antiviral effects. The plasma IgG content and NO content of laying hens in test A, B, C and D4 groups all increased, and the test D group was the most obvious. NO is an intracellular and intercellular signaling molecule. Plays an important role in the immune, nervous and circulatory systems. The mechanism of traditional Chinese medicine to promote NO synthesis may be by activating lymphocytes, promoting the gene expression of inducible nitric oxide synthase (iNOS), increasing the synthesis of iNOS, and then promoting the synthesis and secretion of NO. The increase of NO content promotes blood circulation, So as to achieve the effect of antibacterial and anti-inflammatory. The plasma NOS and iNOS activities of the layer hens in the test group increased, indicating that the immunity of the layer hens was improved.

Effects of traditional Chinese medicine feed additives on laying hen egg production rate, soft broken egg rate, deformed egg rate, average egg weight and feed-to-egg ratio

See Table 2 for the effects of traditional Chinese medicine feed additives on layer egg production rate, soft broken egg rate, deformed egg rate, average egg weight, and feed-to-egg ratio. It can be seen from Table 2 that compared with the control group, A, B, C and D4 groups all improved the production performance of laying hens. In terms of egg production rate, treatment group C had the most obvious improvement effect, and the egg production rate reached 80.92%, which was 11.34% higher than that of the control group, and the difference reached a very significant level (P<0.01). The treatment effect of group D was the most obvious in terms of average egg weight, the average egg weight was 63.97g, which was 6.21% higher than that of the control group, and the difference reached a significant level (P<0.05). In terms of the rate of soft broken eggs, the treatment effect of group D was the most obvious, and the rate of soft broken eggs was 0.21%, which was 62.5% lower than that of the control group, and the difference reached a very significant level (P<0.01). The treatment effect of group D was the most obvious in the rate of deformed eggs. The rate of deformed eggs was 0.09%, which was 43.75% lower than that of the control group, and the difference reached a very significant level (P<0.01). In terms of feed-to-egg ratio, group D had the most obvious treatment effect. The feed-to-egg ratio was 2.12, which was 12.40% lower than that of the control group, and the difference reached a very significant level (P<0.01).

Table 2 The effect of compound traditional Chinese medicine additives on laying hen feed on laying hen egg production rate, soft broken egg rate, deformed egg rate,

Effects of average egg weight and feed-to-egg ratio

Influence of Traditional Chinese Medicine Feed Additives on Egg Quality

Table 3 shows the effect of traditional Chinese medicine feed additives on egg quality in laying hen feed. It can be seen from Table 3 that compared with the control group, the four groups A, B, C, and D all improved the egg quality, and the improvement effect was the most obvious in group D. Its egg yolk ratio is as high as 33.93%, which is 9.06% higher than that of the control group. The Hough unit was 85.49, which was 9.64% higher than that of the control, and the difference reached a significant level (P<0.05). After storage for one month, the Haval unit was 85.13, which was 21.39% higher than that of the control, and the difference reached a very significant level (P<0.01). The normal rate of eggshell color was 77.74%, which was 13.77% higher than that of the control group, and the difference was extremely significant compared with the control group (P<0.01). Compared with the control group, eggshell thickness and egg shape index were increased, but the difference was not significant compared with the control group (P>0.05).

Table 3 The effect of traditional Chinese medicine feed additives on egg quality in laying hen feed

Effects of Traditional Chinese Medicine Feed Additives on Egg Nutrient Components

See Table 4 for the effects of traditional Chinese medicine feed additives on egg nutrient components in laying hen feed. The results showed that the contents of egg lecithin, VA, VE, omega-3 fatty acids, calcium, iron and iodine in the test group were significantly higher than those in the control group (P<0.01 or P<0.05), and the cholesterol content was significantly lower than that in the control group. Group (P<0.01), the content of crude protein and zinc had no significant difference (P>0.05). It shows that the traditional Chinese medicine feed additive in laying hen feed can effectively increase the content of nutrients in eggs, and improve the nutritional value and health care efficacy of eggs.

Table 4 Effects of traditional Chinese medicine feed additives on egg nutrient components in laying hen feed

Effects of Traditional Chinese Medicine Feed Additives on the Contents of Heavy Metals and Antibiotics in Eggs

Table 5 shows the effect of traditional Chinese medicine feed additives on the content of heavy metals and antibiotics in eggs. The results showed that the content of various harmful heavy metals in the eggs of the test group was lower than the national green food standard, and all kinds of antibiotics required by green food were not detected, which met the current national hygienic requirements for green food eggs.

Table 5 Detection results of heavy metals and residues in eggs (mg/Kg)

Changes in the chicken house environment

Test groups A, B, C, and D have a better chicken house environment and less odor. The environment of the hen house in the control group was poor and the smell was strong. This may be due to the reduction of N, P and other odor sources in the feces.

Economic benefit comparison

Egg production in test groups A, B, C, and D4 was higher than that of the control group, and the eggs were sold at the same price, and the economic income of the eggs was higher than that of the control group. The feed consumption of laying hens in test groups A, B, C, and D4 was less than that of the control group, but the test group added pure natural Chinese medicine additives, and the cost was slightly higher than that of the control group. After comprehensive comparison, it is calculated that the benefits of the test groups A, B, C, and D4 are 6.34%, 13.01%, 19.97%, and 21.22% higher than that of the control group, respectively, and the economic benefits are considerable. If the eggs of the test group are sold as nutritious and healthy eggs, the profit will be even greater.

The above is only a specific implementation of the present invention, but the scope of protection of the present invention is not limited thereto, and any changes or replacements that do not come to mind through creative work shall be covered within the scope of protection of the present invention. Therefore, the protection scope of the present invention should be determined by the protection scope defined in the claims.

Claims (4)

1. a Chinese medicine feed additive, it is characterized in that, described Chinese medicine feed additive is made up of the traditional Chinese medicinal material raw materials of following weight portion: Herba Leonuri 35 parts, Spica Prunellae 35 parts, Herba Houttuyniae 1-3 part, Radix Astragali 10-15 part, Radix Codonopsis 5-10 part, Flos Lonicerae 13 parts, Folium Camelliae sinensis 10-15 part, Rumex herbage 15-20 part, Folium Mori 10-15 part, Radix Angelicae Sinensis 3-5 part, Herba Xanthii 35 parts, Maifanitum 13 parts, Massa Medicata Fermentata 13 parts, Pericarpium Citri Reticulatae 5 10 parts, Fructus Schisandrae Chinensis 13 parts, the Radix Polygoni Multiflori 13 parts, Rhizoma Dioscoreae 35 parts, Herba Epimedii 35 parts, 15 parts of Radix Glycyrrhizae, Fructus Forsythiae 35 parts, Semen Cuscutae 13 parts, 13 parts of Thallus Laminariae (Thallus Eckloniae), Fructus Ligustri Lucidi 13 parts,

Its preparation method is, is mixed in proportion by above-mentioned Chinese medicine after drying and is crushed to Chinese medicine particle diameter less than 10 ��m with superfine communication technique, mixes.

2. a kind of Chinese medicine feed additive as claimed in claim 1, it is characterized in that, described Chinese medicine feed additive is made up of the traditional Chinese medicinal material raw materials of following weight portion: Herba Leonuri 5 parts, Spica Prunellae 5 parts, Herba Houttuyniae 3 parts, the Radix Astragali 13 parts, Radix Codonopsis 8 parts, Flos Lonicerae 4 parts, Folium Camelliae sinensis 12 parts, 13 parts of Rumex herbage, 13 parts of Folium Mori, Radix Angelicae Sinensis 2 parts, Herba Xanthii 5 parts, Maifanitum 2 parts, Massa Medicata Fermentata 1 part, Pericarpium Citri Reticulatae 5 parts, Fructus Schisandrae Chinensis 3 parts, the Radix Polygoni Multiflori 3 parts, Rhizoma Dioscoreae 5 parts, Herba Epimedii 5 parts, 3 parts of Radix Glycyrrhizae, Fructus Forsythiae 4 parts, Semen Cuscutae 1 part, 1 part of Thallus Laminariae (Thallus Eckloniae), Fructus Ligustri Lucidi 2 parts;

Its preparation method is, is mixed in proportion by above-mentioned Chinese medicine after drying and is crushed to Chinese medicine particle diameter less than 10 ��m with superfine communication technique, mixes.

3. claim 12 arbitrarily as described in a kind of Chinese medicine feed additive, it is characterised in that its usage is: described Chinese medicine feed additive addition is 0.5% the 2% of laying hens essential ration amount.

4. Chinese medicine feed additive described in claim 1 or 2 is improving the production performance of laying hen, raising laying hen resistance, be effectively improved laying rate and improve egg quality, is reducing layer manure excretion and protection environment, the application reduced during heavy metal and harmful substance in egg remain.