CN103933456B - A kind of Chinese medicine preparation for the treatment of flaccidity - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating flaccidity, which comprises 8-12g of black snake, 10-15g of scorpion, 8-12g of centipede, 12-18g of earthworm, 0.1-0.3g of strychnium chinensis, and 0.1-0.3g of ground turtle by weight. Worm 8-12g, amomum 10-15g, panax notoginseng 3-7g and amber 1-3g; the specific method is: the above-mentioned black snake, scorpion, centipede, earthworm, zhi nux, wood beetle, three Qi and amber are crushed into powder and set aside; decoct the amomum seed twice with water, and collect the volatile oil at the same time; combine the volatile oil collected twice, use cyclodextrin for inclusion, and then dry to obtain the inclusion complex powder; combine the two decoctions , filter, collect the filtrate and concentrate the filtrate to an extract with a relative density of 1.20-1.25 at 60°C, then add the prepared Chinese medicine powder to the extract and mix well, granulate with a 30-50 mesh screen, and use a 40-60°C condition Dry it under the hood, granulate with a 40-80 mesh sieve, add clathrate powder, mix evenly, and tablet it. The composition of the invention is scientifically compatible, reasonable in dosage, easy to take, low in cost and good in effect, and can effectively play the roles of wilting and stretching tendons, dredging meridians and activating collaterals.

Description

A kind of traditional Chinese medicine preparation for treating flaccidity

technical field

The invention relates to medicine, in particular to a traditional Chinese medicine preparation for treating flaccidity.

Background technique

Atrophy Syndrome refers to a class of diseases in which the muscles and bones are weak, the muscles are thin, the skin is numb, and the hands and feet are not used. Clinically, it is more common to have flaccidity and softness of the feet and inability to move freely, so it is also called "flareness". The causes of flaccidity are very complicated, such as exogenous pathogenic factors, internal emotional damage, improper diet, fatigue and prolonged illness. The basic pathogenesis is that the lungs, stomach, liver and kidneys and other viscera are damaged, and the tendons and arteries of the limbs lose their nourishment, such as lung heat and fluid injury, and the body fluid is not distributed; damp heat is soaked, and the blood is not transported; the spleen and stomach are deficient, and the essence is not lost; Loss, dry marrow and muscle flaccidity. At present, there are many drugs for the treatment of flaccidity, but the curative effect is not ideal, so developing a drug with good therapeutic effect has become an urgent problem to be solved.

Contents of the invention

In view of the above situation, in order to overcome the defects of the prior art, the object of the present invention is to provide a Chinese medicine preparation for treating flaccidity, which can effectively solve the flaccidity problem.

The technical scheme solved by the present invention is, a kind of traditional Chinese medicine preparation for the treatment of flaccidity, by weight: black snake 8-12g, whole scorpion 10-15g, centipede 8-12g, earthworm 12-18g, strychnium 0.1- 0.3g, 8-12g of ground beetle, 10-15g of amomum, 3-7g of notoginseng and 1-3g of amber; Ground beetle, Panax notoginseng and amber are crushed into powder and set aside; Add amomum to water 8-10 times the weight of amomum and decoct twice, and collect volatile oil while decocting, until the volatile oil with a total weight of 8-10% of the total weight of water is collected , and then decocted for 1-2h; the volatile oil collected twice was combined, clathrated with cyclodextrin, and then dried to obtain inclusion complex powder; the decoction was combined twice, filtered, the filtrate was collected and the filtrate was concentrated to a relative density of 60°C The extract is 1.20-1.25, and then the prepared Chinese medicine powder is added to the extract and mixed evenly, granulated with a 30-50 mesh screen, dried at 40-60°C, granulated with a 40-80 mesh screen, added to the package Compound powder, mix well, and tablet.

Black snake, sweet in nature and flavor, flat, non-toxic. Return liver channel. It has the effects of expelling wind, activating collaterals, and calming convulsions. For rheumatism obstinate numbness, numbness and spasm, apoplexy, hemiplegia, convulsions and convulsions, tetanus, leprosy and scabies, scrofula and malignant sores.

Scorpio, pungent in nature and flavor, flat. Return liver channel. It has the effects of calming wind and relieving spasm, attacking poison and dispelling stagnation, dredging collaterals and relieving pain.

Centipede, nature and flavor are pungent, warm. It has the effects of expelling wind, relieving convulsions, detoxifying and dissipating stagnation, dredging collaterals and relieving pain.

Earthworm, cold in nature, slightly salty in taste. It has the effects of clearing away heat and calming convulsions, dredging collaterals, relieving asthma, and diuresis. It is used for cerebral thrombosis, cerebral infarction, coronary heart disease, stroke, joint paralysis, numbness of limbs, hemiplegia, hypertension and other diseases.

Nuxe chinensis has the effects of promoting blood circulation and dredging collaterals, anti-inflammatory and antibacterial, pain relief, removing blood stasis and promoting granulation.

Wood beetle, cold in nature, salty in taste. It has the effect of breaking blood stasis and renewing muscles and bones.

Amomi, spicy in taste, warm in nature. Return spleen channel, stomach channel, kidney channel. It has the effects of dispelling dampness and appetizing, warming the spleen and stopping diarrhea, regulating qi and preventing miscarriage.

Radix Notoginseng has the effects of dispelling blood stasis and stopping bleeding, reducing swelling and relieving pain. Can control hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic bleeding, chest and abdomen tingling pain, tumbling pain.

Amber, sweet in nature and flavor, flat. Guixin; Liver; Small Intestine Channel; Bladder; Lung; Spleen Channel. It has the effects of calming the nerves, dispelling blood stasis and stopping bleeding, diuresis and dredging stranguria, removing nebula and improving eyesight.

In the traditional Chinese medicine preparation of the present invention, black snake, strychnium chinensis, ground beetle, and earthworm have the merit of dredging the meridian and activating collaterals, and can be applied to the turbidity and poison of invading tendons and joints, or the stubborn numbness caused by the external skin, and are monarch drugs; Scorpion and centipede are the key medicines for Xifeng Sanjie, with the fastest running power, reaching viscera internally, and externally traveling meridians, they can be opened wherever qi and blood are condensed, and they are ministerial medicines; , Warm the middle, have the qi of reconciling the five internal organs, reduce the poison of the monarch and ministers, Sanqi, amber dispel blood stasis and activate, can lead all medicines to return to the dantian, and serve as adjuvant medicines. Combination of various medicines can achieve the functions of atrophy, stretching tendons, clearing meridians and activating collaterals. It is especially suitable for muscle laxity, limb flaccidity and weakness caused by various reasons, movement disorders without heat symptoms, and limb muscles and bones ache caused by wind-cold damp stagnation in meridians and collaterals, etc. disease. The invention adopts natural Chinese medicinal materials as raw materials, has wide sources of raw materials, simple preparation method, easy industrial promotion, and good social and economic benefits.

detailed description

The specific implementation of the present invention will be described in detail below in conjunction with the examples.

Example 1

The traditional Chinese medicine preparation for the treatment of flaccidity according to the present embodiment, by weight: 10g of black snake, 12g of scorpion, 10g of centipede, 15g of earthworm, 0.2g of Strychnis chinensis, 10g of ground beetle, 12g of amomum, 5g of Panax notoginseng and 2g of amber Made; the specific method is: pulverize the above-mentioned black snake, scorpion, centipede, earthworm, chrysanthemum, wood beetle, notoginseng and amber into powder, and set aside; add amomum to 8 times the weight of amomum and fry Boiling twice, collecting volatile oil while decocting, and decocting for 1 hour after collecting the volatile oil with a total weight of 8% of the total weight of water added; combining the volatile oil collected twice, using cyclodextrin for clathrate, and then drying to obtain clathrate powder; Combine the two decoctions, filter, collect the filtrate and concentrate the filtrate to an extract with a relative density of 1.20 at 60°C, then add the prepared Chinese medicine powder to the extract and mix well, granulate with a 40-mesh screen, and granulate at 50°C Dry, granulate with a 40-mesh sieve, add clathrate powder, mix well, and tablet.

Example 2

The traditional Chinese medicine preparation for the treatment of flaccidity in this example, by weight: 8g of black snake, 10g of scorpion, 8g of centipede, 12g of earthworm, 0.1g of Strychnis chinensis, 8g of ground beetle, 10g of amomum, 3g of Panax notoginseng and 1g of amber Made; the specific method is: pulverize the above-mentioned black snake, scorpion, centipede, earthworm, chrysanthemum, wood beetle, Panax notoginseng and amber into powder, and set aside; add Amomum 9 times the weight of Amomum to decoct Boil twice, collect volatile oil while decocting, and decoct for 1.5 hours after collecting volatile oil with a total weight of 9% of the total weight of water added; combine the volatile oil collected twice, use cyclodextrin for clathrate, and then dry to obtain clathrate powder Combine two decoctions, filter, collect the filtrate and concentrate the filtrate to an extract with a relative density of 1.25 at 60°C, then add the prepared Chinese medicine powder to the extract and mix well, granulate with a 30-mesh screen, and granulate at 40°C Dry it under the hood, granulate with a 60-mesh sieve, add clathrate powder, mix well, and tablet it.

Example 3

The traditional Chinese medicine preparation for the treatment of flaccidity in this example, by weight: 12g of black snake, 15g of scorpion, 12g of centipede, 18g of earthworm, 0.3g of Strychnis chinensis, 12g of ground beetle, 15g of amomum, 7g of notoginseng and 3g of amber Made; the specific method is: pulverize the above-mentioned black snake, scorpion, centipede, earthworm, chrysanthemum, wood beetle, Panax notoginseng and amber into powder, and set aside; Boiling twice, collecting volatile oil while decocting, and decocting for 2 hours after collecting volatile oil with a total weight of 10% of the total weight of water added; combining the volatile oil collected twice, using cyclodextrin for clathrate, and then drying to obtain clathrate powder; Combine the two decoctions, filter, collect the filtrate and concentrate the filtrate to an extract with a relative density of 1.23 at 60°C, then add the prepared Chinese medicine powder to the extract and mix well, granulate with a 50-mesh screen, and granulate at 60°C Dry, granulate with 80-mesh sieve, add clathrate powder, mix well, and tablet.

The prescription of the present invention is scientific in compatibility, reasonable in dosage, easy to take, low in cost and good in effect, and can effectively play the role of wilting and stretching tendons, dredging meridian and activating collaterals, and achieved good results through clinical trials. The relevant test conditions are as follows:

1. Diagnostic criteria

For the key points of diagnosis of flaccidity, refer to "Internal Medicine of Traditional Chinese Medicine":

(1) Muscle atrophy, weakness, and even paralysis in limbs. Some patients are accompanied by muscle atrophy.

(2) Due to muscle flaccidity and weakness, there may be symptoms such as eyelid drooping, discrimination, hoarseness and low voice, and weakness in raising the head, and even affect breathing and swallowing.

(3) Some patients had a history of colds and diarrhea before the onset of the disease, and some patients had a history of exposure to neurotoxic drugs or family genetic history.

2. Efficacy evaluation

With reference to the nimodipine method adopted in the "Guiding Principles for Clinical Research of New Chinese Medicines for the Treatment of Stroke": (score before treatment-score after treatment)/score before treatment×100%, expressed as a percentage. Complete remission: 85%; markedly effective 50%-85%; effective 20%-50%; invalid <20%.

3. Results:

Randomly select 520 patients with diagnosed flaccidity, and use the traditional Chinese medicine preparation of the present invention to treat for 12 weeks, 3 tablets (0.5g/tablet) per day, 1 tablet each time in the morning, noon and evening, among them, among 520 patients, the effect is markedly 190; effective 250; invalid 80 cases, the effective rate was 84.62%.

The above test results show that the traditional Chinese medicine preparation of the present invention can effectively play the role of shrinking and stretching tendons, dredging meridians and activating collaterals, which is a great innovation in the field of traditional Chinese medicine.

Claims (4)

1. treat a Chinese medicine preparation for flaccidity, it is characterized in that, by weighing scale: Zaocys 8-12g, Scorpio 10-15g, Scolopendra 8-12g, Pheretima 12-18g, Semen Strychni (processed) 0.1-0.3g, Eupolyphaga Seu Steleophaga 8-12g, Fructus Amomi 10-15g, Radix Notoginseng 3-7g and succinum 1-3g make; Concrete grammar is: above-mentioned Zaocys, Scorpio, Scolopendra, Pheretima, Semen Strychni (processed), Eupolyphaga Seu Steleophaga, Radix Notoginseng and Succinum powder are broken into powder, for subsequent use; Fructus Amomi is added Fructus Amomi weight 8-10 soak by water doubly 2 times, decoct and collect volatile oil simultaneously, in time collecting the volatile oil of the gross weight 8-10% weight that adds water, then decoct 1-2h; Merge the volatile oil of twice collection, adopt cyclodextrin to carry out enclose, then drying obtains clathrate powder; Merge twice decocting liquid, filter, collecting filtrate and filtrate being concentrated into 60 DEG C of relative densities is the extractum of 1.20-1.25, then the Chinese medicinal powder of preparation is added in extractum and mix, granulate with 30-50 eye mesh screen, dry under 40-60 DEG C of condition, 40-80 eye mesh screen granulate, add clathrate powder, mixing, tabletting and get final product.

2. the Chinese medicine preparation for the treatment of flaccidity according to claim 1, is characterized in that, by weighing scale: Zaocys 10g, Scorpio 12g, Scolopendra 10g, Pheretima 15g, Semen Strychni (processed) 0.2g, Eupolyphaga Seu Steleophaga 10g, Fructus Amomi 12g, Radix Notoginseng 5g and succinum 2g make; Concrete grammar is: above-mentioned Zaocys, Scorpio, Scolopendra, Pheretima, Semen Strychni (processed), Eupolyphaga Seu Steleophaga, Radix Notoginseng and Succinum powder are broken into powder, for subsequent use; Fructus Amomi is added the soak by water 2 times of Fructus Amomi weight 8 times, decoct and collect volatile oil simultaneously, in time collecting the volatile oil of gross weight 8% weight that adds water, then decoct 1h; Merge the volatile oil of twice collection, adopt cyclodextrin to carry out enclose, then drying obtains clathrate powder; Merge twice decocting liquid, filter, collecting filtrate and filtrate being concentrated into 60 DEG C of relative densities is the extractum of 1.20, is then added in extractum by the Chinese medicinal powder of preparation and mixes, granulate with 40 eye mesh screens, dry under 50 DEG C of conditions, 40 eye mesh screen granulate, add clathrate powder, mixing, tabletting and get final product.

3. the Chinese medicine preparation for the treatment of flaccidity according to claim 1, is characterized in that, by weighing scale: Zaocys 8g, Scorpio 10g, Scolopendra 8g, Pheretima 12g, Semen Strychni (processed) 0.1g, Eupolyphaga Seu Steleophaga 8g, Fructus Amomi 10g, Radix Notoginseng 3g and succinum 1g make; Concrete grammar is: above-mentioned Zaocys, Scorpio, Scolopendra, Pheretima, Semen Strychni (processed), Eupolyphaga Seu Steleophaga, Radix Notoginseng and Succinum powder are broken into powder, for subsequent use; Fructus Amomi is added the soak by water 2 times of Fructus Amomi weight 9 times, decoct and collect volatile oil simultaneously, in time collecting the volatile oil of gross weight 9% weight that adds water, then decoct 1.5h; Merge the volatile oil of twice collection, adopt cyclodextrin to carry out enclose, then drying obtains clathrate powder; Merge twice decocting liquid, filter, collecting filtrate and filtrate being concentrated into 60 DEG C of relative densities is the extractum of 1.25, is then added in extractum by the Chinese medicinal powder of preparation and mixes, granulate with 30 eye mesh screens, dry under 40 DEG C of conditions, 60 eye mesh screen granulate, add clathrate powder, mixing, tabletting and get final product.

4. the Chinese medicine preparation for the treatment of flaccidity according to claim 1, is characterized in that, by weighing scale: Zaocys 12g, Scorpio 15g, Scolopendra 12g, Pheretima 18g, Semen Strychni (processed) 0.3g, Eupolyphaga Seu Steleophaga 12g, Fructus Amomi 15g, Radix Notoginseng 7g and succinum 3g make; Concrete grammar is: above-mentioned Zaocys, Scorpio, Scolopendra, Pheretima, Semen Strychni (processed), Eupolyphaga Seu Steleophaga, Radix Notoginseng and Succinum powder are broken into powder, for subsequent use; Fructus Amomi is added the soak by water 2 times of Fructus Amomi weight 10 times, decoct and collect volatile oil simultaneously, in time collecting the volatile oil of gross weight 10% weight that adds water, then decoct 2h; Merge the volatile oil of twice collection, adopt cyclodextrin to carry out enclose, then drying obtains clathrate powder; Merge twice decocting liquid, filter, collecting filtrate and filtrate being concentrated into 60 DEG C of relative densities is the extractum of 1.23, is then added in extractum by the Chinese medicinal powder of preparation and mixes, granulate with 50 eye mesh screens, dry under 60 DEG C of conditions, 80 eye mesh screen granulate, add clathrate powder, mixing, tabletting and get final product.