CN103920079A - Traditional Chinese medicine composition for treating canine demodicidosis and preparation as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating canine demodicidosis and preparation as well as preparation method and application thereof Download PDFInfo
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Abstract
本发明公开了用于治疗犬蠕形螨病的中药组合物、制剂及其制备方法和应用，中药组合物按重量份计由大枫子4～6份，苦参2～4份，花椒7～9份、儿茶5～7份、地肤子5-7份、百部4～6份、蛇床子3～5份和轻粉2～4份组成，配方独特，安全性好；本发明中以中药组合物为活性成分制成制剂，其制备方法简单，使用方便，用于治疗蠕形螨感染的患犬疗效确切，具有较好的市场前景。The invention discloses a traditional Chinese medicine composition, a preparation and a preparation method and application thereof for treating canine demodicosis. ～9 parts, 5～7 parts of catechu, 5-7 parts of Kochia chinensis, 4～6 parts of Baibu, 3～5 parts of cnidium and 2～4 parts of light powder, with unique formula and good safety; the present invention The traditional Chinese medicine composition is used as an active ingredient to prepare a preparation, the preparation method is simple, the use is convenient, the curative effect is definite for treating dogs infected by Demodex, and the preparation has good market prospect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be particularly used for the treatment of the Chinese medicine composition of demodicidosis disease, also relate to and contain the preparation that Chinese medicine composition is made, and the preparation method and application of preparation.
Background technology
Demodicidosis disease is the common dermatosis of dog, very large to the harm of domestic pets dog and foster dog industry, and demodicidosis is mostly parasitic on the top of morbidity skin follicle, proceeds to gradually bottom, seldom parasitizes in sebaceous gland.Except parasitizing inside and outside hair follicle, can also live in the skin histology and lymph node of dog, and breeding therein, the in the situation that of Immune Dysfunction, can bring out primary disease.And primary disease has infectiousness, the sickness rate of brood dog is up to 80%～90%.Acaricide directly contacts with sick dog, cat mainly due to healthy dogs, cat or by being caused infection by mediate contacts such as the dog of demodicid mite and ovum pollution thereof, Mao She, apparatus, also can propagate cause of disease by management personnel or veterinary personnel's clothes or other carriers.
The pathological changes of demodicidosis is mainly dermatitis, sebaceous gland-folliculitis.Can be divided into clinically two types: (1) squama type, the multiple eyelid and around, locate between bicker, forehead, nose and neck bottom, ancon, toe etc. be born in, affected part loses hair or feathers, occurs bald spot, and accompany by the slight flushing of skin and the scurf that silvery white has stickiness occurs, skin seems slightly coarse and chaps, or with lesser tubercle, skin was bluish grey white or copper afterwards, and affected part is itched hardly; (2) pustule type, is mainly in neck, breast, burst inner side and other positions, and the later stage is spread whole body, the large stretch of depilation of body surface, and large stretch of erythema, pachyderma, often forms gauffer.Have diffusivity Semen setariae to the large pustular eruption of wheat grain, pus is bluish red color, discharges pus during extrusion, includes a large amount of vermiform mites and worm's ovum, after pustule ulceration, forms ulcer, and incrustation, has unpleasant stench, and pustule type does not almost have pruritus.
For the treatment of demodicidosis, need be administered to and the method for dipping could be effected a radical cure with Western medicine at present, but the medicine for external use (unguentum and lotion) using mostly clinically is the western medicine composition that toxicity is larger, dog affected part embrocate or whole body dipping process in be easy to be licked and lick and occur poisoning by dog, the lighter's appetite is absolutely useless, spirit is depressed, vomit, serious caused dog is dead.Therefore, be badly in need of a kind of toxicity less, the Chinese medicine composition for the treatment of demodicidosis disease, avoid because of dog lick lick occur poisoning.
Summary of the invention
In view of this, one of object of the present invention is to be provided for treating the Chinese medicine composition of demodicidosis disease, formula is unique, and safety is good, meets < < Chinese veterinary pharmacopoeia > > standard; Two of object of the present invention is to provide take the preparation that above-mentioned Chinese medicine composition is active component, and said preparation composition is simple, and cost is low; Three of object of the present invention is to provide the preparation method of above-mentioned preparation, and its preparation method is simple, does not need special installation; Four of object of the present invention is to provide the application of above-mentioned Chinese medicine composition.
For achieving the above object, the invention provides following technical scheme:
1, the Chinese medicine composition that is used for the treatment of demodicidosis disease, by weight by 4～6 parts of Semen Hydnocarpi, 2～4 parts of Radix Sophorae Flavescentiss, 7～9 parts, Pericarpium Zanthoxyli, 5～7 parts, catechu, Fructus Kochiae 5-7 part, Radix Stemonae 4-6 part, Fructus Cnidii 3-5 part and 2～4 parts of compositions of Calomelas.
Preferably, by weight by 6 parts of Semen Hydnocarpi, 4 parts of Radix Sophorae Flavescentiss, 9 parts, Pericarpium Zanthoxyli, 7 parts, catechu, 7 parts of the Fructus Kochiae, 6 parts of the Radixs Stemonae, 5 parts of Fructus Cnidiis and 4 parts of compositions of Calomelas.
Preferably, by weight by 5 parts of Semen Hydnocarpi, 3 parts of Radix Sophorae Flavescentiss, 8 parts, Pericarpium Zanthoxyli, 6 parts, catechu, 6 parts of the Fructus Kochiae, 5 parts of the Radixs Stemonae, 4 parts of Fructus Cnidiis and 3 parts of compositions of Calomelas.
Preferably, by weight by 4 parts of Semen Hydnocarpi, 2 parts of Radix Sophorae Flavescentiss, 7 parts, Pericarpium Zanthoxyli, 5 parts, catechu, 5 parts of the Fructus Kochiae, 4 parts of the Radixs Stemonae, 3 parts of Fructus Cnidiis and 2 parts of compositions of Calomelas.
Preferably, by weight by 4 parts of Semen Hydnocarpi, 2 parts of Radix Sophorae Flavescentiss, 7 parts, Pericarpium Zanthoxyli, 5 parts, catechu, 5 parts of the Fructus Kochiae, 6 parts of the Radixs Stemonae, 5 parts of Fructus Cnidiis and 4 parts of compositions of Calomelas.
In the present invention, the effect of each raw material is as follows:
Semen Hydnocarpi (Hydnocarpus hainanensis (Merr.) Sleum.) is used as medicine with seed, and this medicine is pungent, and heat is poisonous, has and dispels the wind, counteracting toxic substances, the effect of parasite killing.
Radix Sophorae Flavescentis (Sophora flavescens) is the root of the plant of pulse family Radix Sophorae Flavescentis genus, cold in nature, there are heat clearing away, dampness, killing parasites for relieving itching, local antibacterial antiinflammation, the auricle edema that its main component matrine causes mouse knoting oil, the mouse peritoneal that acetic acid causes ooze out increase, rat carrageenan footpad swelling, all there is inhibitory action, illustrate that it has antiinflammatory action.
Pericarpium Zanthoxyli (Zanthoxylum bungeanum) is the dry mature skin of Rutaceae shrub or dungarunga plant green pepper, and Pericarpium Zanthoxyli acrid in the mouth, hot in nature is returned spleen, stomach warp.The effect with warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing removing toxic substances, antipruritic solution raw meat.
Catechu (Acacia catechu) is the peeling branch of pulse family albizzia plant catechu tree (Acaciacatechu (L.f.) Willd.), dry dry soft extracts.
The Fructus Kochiae (Kochia scoparia (L.) Schrad.) is the dry mature fruit of chenopod Fructus Kochiae, and acrid in the mouth, hardship are cold, have clearing away heat-damp and promoting diuresis, and the effect of dispelling wind for relieving itching, can treat the dermatosiss such as rubella, eczema, Jie Xian, skin pruritus.
The Radix Stemonae is the dried root of Stemonaceae plant Radix Stemonae (Stemona sessilifolia (Miq.) Miq.), Radix stemonae japonicae (Stemona japonica (Bl.) Miq.) or radix stemonae tuberosae (Stemona tuberosa Lour.), sweet, bitter, tepor.
Fructus Cnidii: for the dry mature fruit of samphire cnidium monnieri (Cnidium monnieri (L.) Cuss.), pungent, bitter, temperature, slightly poisonous, there is dampness, dispel the wind, parasite killing, antipruritic, the effect of warming the kidney to invigorate YANG.
Calomelas: be calomel (Hg2Cl2), pungent, cold, poisonous, there is counteracting toxic substances, parasite killing, holds back the effect of wound, external parasite killing, counteracting toxic substances, sore.
2, a kind ofly take the preparation that described Chinese medicine composition is active component.
Preferably, described preparation is unguentum.Those skilled in the art also can need to make the dosage forms such as powder, extractum according to clinical, can also make lotion.
3, the preparation method of described preparation, by the Semen Hydnocarpi of recipe quantity, Radix Sophorae Flavescentis, Pericarpium Zanthoxyli, catechu, the Fructus Kochiae, the Radix Stemonae, Fructus Cnidii and Calomelas are ground into fine powder, cross 200 mesh sieves, and then adding temperature is the Oleum Brassicae campestris of 50～60 ℃, and mix homogeneously is made unguentum.
4, the application of described Chinese medicine composition in the medicine of preparation treatment demodicidosis disease.
Beneficial effect of the present invention is: the invention discloses a kind of Chinese medicine composition that is used for the treatment of demodicidosis disease, formula is unique, meet < < Chinese veterinary pharmacopoeia > > standard, and safety is good, in treatment, can demodicidosis not to make animal generation poisoning, solve at present for the larger problem of external Western medicine preparation toxicity in demodicidosis treatment; The invention also discloses and take the preparation that Chinese medicine composition is active component, said preparation composition is simple, and preparation cost is low, and convenient drug administration, and determined curative effect can be removed the vermiform mite polypide in vermiform mite sufferer dog skin at all.
The specific embodiment
Below in conjunction with specific embodiment, the preferred embodiments of the present invention are described in detail.The experimental technique of unreceipted actual conditions in embodiment, conventionally according to normal condition or the condition of advising according to manufacturer.
Embodiment 1
The Chinese medicine composition that is used for the treatment of demodicidosis disease, its prescription is as follows:
Prescription 1: formed by following component by weight: 6 parts of Semen Hydnocarpi, 4 parts of Radix Sophorae Flavescentiss, 4 parts of 9 parts, Pericarpium Zanthoxyli, 7 parts, catechu, 7 parts of the Fructus Kochiae, 6 parts of the Radixs Stemonae, 5 parts of Fructus Cnidiis and Calomelass.
Prescription 2: formed by following component by weight: 5 parts of Semen Hydnocarpi, 3 parts of Radix Sophorae Flavescentiss, 3 parts of 8 parts, Pericarpium Zanthoxyli, 6 parts, catechu, 6 parts of the Fructus Kochiae, 5 parts of the Radixs Stemonae, 4 parts of Fructus Cnidiis and Calomelass.
Prescription 3: formed by following component by weight: 4 parts of Semen Hydnocarpi, 2 parts of Radix Sophorae Flavescentiss, 2 parts of 7 parts, Pericarpium Zanthoxyli, 5 parts, catechu, 5 parts of the Fructus Kochiae, 4 parts of the Radixs Stemonae, 3 parts of Fructus Cnidiis and Calomelass.
Prescription 4: formed by following component by weight: 4 parts of Semen Hydnocarpi, 2 parts of Radix Sophorae Flavescentiss, 7 parts, Pericarpium Zanthoxyli, 5 parts, catechu, 5 parts of the Fructus Kochiae, 6 parts of the Radixs Stemonae, 5 parts of Fructus Cnidiis, 4 parts of Calomelass.
For easy to use, make Chinese medicine composition give full play to drug effect, Chinese medicine composition is made to required clinically dosage form.In the present invention, Chinese medicine composition is made to unguentum, its preparation method is as follows: by the Semen Hydnocarpi of recipe quantity, Radix Sophorae Flavescentis, Pericarpium Zanthoxyli, catechu, the Fructus Kochiae, the Radix Stemonae, Fructus Cnidii and Calomelas are ground into fine powder, cross 200 mesh sieves, then adding temperature is the Oleum Brassicae campestris of 50～60 ℃, and mix homogeneously is made unguentum, and the addition of Oleum Brassicae campestris adds 100mL Oleum Brassicae campestris by every 20g medicated powder.
Application Example 1
15 of demodectic sick dogs are occurred to infect in certain pet dog breeding farm treats.Dog infects demodectic clinical main manifestations, suffers from the play of dog whole body and itches, and constantly uses limbs pruritus, and on doghouse wall, rubdown on cage tool.Affected part depilation, morbidity the most seriously shows in extremity and occurs thickly dotted pustule under flank, cervical region, back be visible more red pimple also, local blister or the abscess of forming, after pushing skin with hands, the affected part sparse by hair use blade scraping scurf and secretions, can see under the microscope typical vermiform mite polypide, in conjunction with clinical symptoms, be diagnosed as the demodicidosis of dog.Therapeutic Method: be evenly applied in trouble dog site of disease after the Chinese medicine composition of embodiment 1 prescription 1 is made to unguentum, use every day 2 times, be used in conjunction 7 days, add up therapeutic effect after 7 days, result is as shown in table 1.
Table 1, Application Example 1 curative effect evaluation
| Treatment dog number of elements | Cure number of elements | Effective number of elements | Invalid number of elements | Poisoning number of elements |
| 15 | 11 | 13 | 2 | 0 |
As shown in Table 1, treat after 7 days that to 13, to suffer from dogs effective, cures 11, and in medication after 2 days, the red pimple of suffering from dog health reduces gradually, gargalesthesia obviously weakens, and forms a scab gradually in the position of generation ulceration.After medication 7 days, cure and suffer from the disappearance of dog pimple, scrape off ill skin scurf, microscope is differentiated without polypide.
Application Example 2
Certain meat dog plant is occurred to dermopathic 30 and suffer from dogs and treat, symptom main manifestations is: a large amount of red pimples of local serious depilation, and there is pustule in pimple central authorities, some position ulceration infects, have transudate or pus, there is incrustation part, and pathological changes is comparatively serious inside extremity.Suffer from the play of dog whole body and itch, constantly with the hind leg disease sites of scratching, the affected part that frequently rubs on wall around, causes local depilation, hemorrhage, pollutes.At disease sites, with after hands extruding skin, with blade scraping scurf, microscopy, finds that there is vermiform mite polypide, in conjunction with clinical symptoms, is diagnosed as Human Follicle Mite Infection.Therapeutic Method: the Chinese medicine composition of embodiment 1 prescription 2 is made to unguentum and be evenly applied in trouble dog site of disease, embrocate every day 2 times, be used in conjunction 5 days, after medication, red pimple reduces gradually, and inflammatory reaction obviously reduces, and gargalesthesia weakens and fades away.After medication in the 5th day, symptom disappears, and at original ill position, with after hands extruding skin, with blade scraping scurf and in test under microscope, result majority of cases is not found vermiform mite polypide.Then statistics is treated the therapeutic effect after 5 days, and result is as shown in table 2.
Table 2, Application Example 2 curative effect evaluations
| Treatment dog number of elements | Cure number of elements | Effective number of elements | Invalid number of elements | Poisoning number of elements |
| 30 | 27 | 29 | 1 | 0 |
As shown in Table 2, treat and within 5 days, cure to suffer from afterwards 27 of dogs, effectively number of elements is 29, shows that Chinese medicine composition of the present invention can effectively treat demodicidosis and infect, and thing to suffer from dog poisoning.
Application Example 3
The sick dogs of 30 dermatosiss of certain pets hospital are treated, and clinical symptoms shows as: disease sites depilation, there are a large amount of red pimples, and there is pustule in pimple central authorities, and there is exudate at indivedual positions or has formed a scab, and pathological changes is comparatively serious inside extremity, depilation, erythema.Have gargalesthesia, the disease sites of often scratching, or friction affected part, cause ulceration, hemorrhage, pollution.At disease sites, with after hands extruding skin, with blade scraping scurf, microscopy, finds that there is vermiform mite polypide, in conjunction with clinical symptoms, is diagnosed as Human Follicle Mite Infection.Therapeutic Method: the Chinese medicine composition of embodiment 1 prescription 3 is made to unguentum and be evenly applied in and suffer from dog site of disease, embrocate every day 2 times, medication is after 3 days, and scytitis significant reaction reduces, the behavior fading away such as scratch.After medication in the 5th day, symptom alleviates and disappears gradually.At original ill position, with after hands extruding skin, with blade scraping scurf, microscopy, result majority of cases is not found vermiform mite polypide.Then add up the therapeutic effect of medication after 5 days, result is as shown in table 3.
Table 3, Application Example 3 curative effect evaluations
| Treatment dog number of elements | Cure number of elements | Effective number of elements | Invalid number of elements | Poisoning number of elements |
| 30 | 24 | 28 | 2 | 0 |
As shown in Table 3, medication 5 days is cured afterwards and is suffered from 24 of dogs, and effectively number of elements is 28, shows that Chinese medicine composition of the present invention can effectively treat demodicidosis and infect, and poisoning without suffering from dog.
Application Example 4
20 outpatient services of pet clinic are suffered to the sick dog of dermatosis treats.Clinical symptom: affected part depilation, there is large stretch of red pimple and pimple, there is exudate part, and the depilation of extremity inner side is comparatively serious.Have gargalesthesia, the disease sites of often scratching, or friction affected part, cause ulceration, hemorrhage, pollution.At disease sites, with after hands extruding skin, with blade scraping scurf, microscopy, finds that there is vermiform mite polypide, in conjunction with clinical symptoms, is diagnosed as Human Follicle Mite Infection.Therapeutic Method: the Chinese medicine composition of embodiment 1 prescription 4 is made to unguentum and be evenly applied in and suffer from dog site of disease, embrocate every day 2 times, medication is after 4 days, and scytitis significant reaction reduces, the behavior fading away such as scratch, after medication in the 5th day, symptom alleviates gradually.At original ill position, with after hands extruding skin, with blade scraping scurf, microscopy, result majority of cases is not found vermiform mite polypide.Then add up the therapeutic effect of medication after 5 days, result is as shown in table 4.
Table 4, Application Example 4 curative effect evaluations
| Treatment dog number of elements | Cure number of elements | Effective number of elements | Invalid number of elements | Poisoning number of elements |
| 20 | 15 | 18 | 2 | 0 |
As shown in Table 4, medication 5 days is cured afterwards and is suffered from 15 of dogs, and effectively number of elements is 18, shows that Chinese medicine composition of the present invention can effectively treat demodicidosis and infect, and poisoning without suffering from dog.
Application Example 5
To the sick dog of 20 outpatient service dermatosiss of pet clinic, symptom is similar to the case of Application Example 4, through microscopy, is diagnosed as Human Follicle Mite Infection.With the Australia of selling on market, can control skin ointment (Australia PETLOVER company) disease sites is embrocated to treatment, every day 2 times, be used in conjunction 5 days, medication is after 4 days, and scytitis significant reaction reduces, the behavior fading away such as scratch.After medication in the 5th day, symptom alleviates gradually.Ill position original, presses out Chang Fangfa scraping scurf microscopy, and some cases is not found vermiform mite polypide, then adds up therapeutic effect result, and result is as shown in table 5.
Table 5, Australia can be controlled skin ointment curative effect and evaluate (western medicine group)
| Treatment dog number of elements | Cure number of elements | Effective number of elements | Invalid number of elements | Poisoning number of elements |
| 20 | 12 | 15 | 5 | 2 |
Result shows, skin ointment can be controlled in Australia has therapeutic effect equally to vermiform mite, but has 2 to suffer from dogs and occur poisoningly, shows that Western medicine Acaricide cream also can make to suffer from dog at treatment Human Follicle Mite Infection simultaneously poisoning.
Compare Application Example 1～5 therapeutic effect, result is as shown in table 6.
Table 6, Application Example 1～5 therapeutic effect comparison
| Group | Application Example 1 | Application Example 2 | Application Example 3 | Application Example 4 | Application Example 5 |
| Treatment dog quantity | 15 | 30. | 30 | 20 | 20 |
| Cure rate (%) | 73.3 * | 90.0 ** | 80.0 ** | 75.0 ** | 60.0 |
| Effective percentage (%) | 86.7 * | 96.6 ** | 93.3 ** | 90 ** | 75.0 |
| Inefficiency (%) | 13.3 ** | 3.3 ** | 6.7 ** | 10.0 ** | 25.0 |
| Poisoning rate (%) | 0 ** | 0 ** | 0 ** | 0 ** | 10.0 |
Note: " * " P < 0.05, " * * " P < 0.01
As shown in Table 6, the present invention writes out a prescription 1～4 Chinese medicine composition cure rate all higher than the western medicine group of Application Example 5; And the western medicine group inefficiency of Application Example 5 is higher than the Chinese medicine composition of prescription 1～4; The statistical result showed of poisoning rate: the Chinese medicine composition poisoning rate of prescription 1～4 is the extremely remarkable western medicine group lower than Application Example 5 all.In addition, in prescription 1～4, the cure rate of prescription 2 and effective percentage are all significantly higher than the Chinese medicine composition of prescription 1,3 and 4.
Therefore Chinese medicine composition disclosed by the invention can effectively be treated demodicidosis infection, and toxicity is low, and after using, dog there will not be poisoning symptom, and safety is good.
Finally explanation is, above preferred embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is described in detail by above preferred embodiment, but those skilled in the art are to be understood that, can to it, make various changes in the form and details, and not depart from the claims in the present invention book limited range.
Claims (9)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105749088A (en) * | 2016-04-25 | 2016-07-13 | 王天笑 | Traditional Chinese medicine composition for treating mange and acariasis of fur animals and preparation method and application thereof |
| CN110420266A (en) * | 2019-08-11 | 2019-11-08 | 广州川研化学科技有限公司 | A kind of three green pepper anti-acne anti-mite agent |
| CN114748590A (en) * | 2022-05-07 | 2022-07-15 | 王志军 | Pesticide for preventing and treating ectoparasites of livestock and poultry and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1119939A (en) * | 1994-08-05 | 1996-04-10 | 宋凯 | Pesticidal shampoo for pet |
| CN102327363A (en) * | 2011-07-12 | 2012-01-25 | 天津生机集团股份有限公司 | Traditional Chinese medicinal composition for treating sarcoptic acariasis of sheep |
| CN102908567A (en) * | 2012-11-06 | 2013-02-06 | 山西省生态畜牧产业管理站 | Chinese herbal medicine ointment for treating sheep mite and preparation method of same |
| CN103142908A (en) * | 2013-03-29 | 2013-06-12 | 武汉中博绿亚生物科技有限公司 | Spray for killing mites on body surface of pet and preparation method of spray |
-
2014
- 2014-04-25 CN CN201410171418.9A patent/CN103920079A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1119939A (en) * | 1994-08-05 | 1996-04-10 | 宋凯 | Pesticidal shampoo for pet |
| CN102327363A (en) * | 2011-07-12 | 2012-01-25 | 天津生机集团股份有限公司 | Traditional Chinese medicinal composition for treating sarcoptic acariasis of sheep |
| CN102908567A (en) * | 2012-11-06 | 2013-02-06 | 山西省生态畜牧产业管理站 | Chinese herbal medicine ointment for treating sheep mite and preparation method of same |
| CN103142908A (en) * | 2013-03-29 | 2013-06-12 | 武汉中博绿亚生物科技有限公司 | Spray for killing mites on body surface of pet and preparation method of spray |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105749088A (en) * | 2016-04-25 | 2016-07-13 | 王天笑 | Traditional Chinese medicine composition for treating mange and acariasis of fur animals and preparation method and application thereof |
| CN110420266A (en) * | 2019-08-11 | 2019-11-08 | 广州川研化学科技有限公司 | A kind of three green pepper anti-acne anti-mite agent |
| CN110420266B (en) * | 2019-08-11 | 2021-07-16 | 广州川研化学科技有限公司 | Acne-removing and mite-removing agent with three kinds of pepper |
| CN114748590A (en) * | 2022-05-07 | 2022-07-15 | 王志军 | Pesticide for preventing and treating ectoparasites of livestock and poultry and preparation method thereof |
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Application publication date: 20140716 |