CN103875684A - High efficient sterilizing composition containing initium - Google Patents
High efficient sterilizing composition containing initium Download PDFInfo
- Publication number
- CN103875684A CN103875684A CN201210559646.4A CN201210559646A CN103875684A CN 103875684 A CN103875684 A CN 103875684A CN 201210559646 A CN201210559646 A CN 201210559646A CN 103875684 A CN103875684 A CN 103875684A
- Authority
- CN
- China
- Prior art keywords
- azoles mepanipyrim
- active component
- metalaxyl
- weight ratio
- mepanipyrim
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- GGKQIOFASHYUJZ-UHFFFAOYSA-N ametoctradin Chemical compound NC1=C(CCCCCCCC)C(CC)=NC2=NC=NN21 GGKQIOFASHYUJZ-UHFFFAOYSA-N 0.000 title abstract description 4
- 230000001954 sterilising effect Effects 0.000 title abstract description 3
- 201000010099 disease Diseases 0.000 claims abstract description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 26
- 239000005821 Propamocarb Substances 0.000 claims abstract description 24
- WZZLDXDUQPOXNW-UHFFFAOYSA-N propamocarb Chemical compound CCCOC(=O)NCCCN(C)C WZZLDXDUQPOXNW-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000005808 Metalaxyl-M Substances 0.000 claims abstract description 18
- ZQEIXNIJLIKNTD-GFCCVEGCSA-N metalaxyl-M Chemical compound COCC(=O)N([C@H](C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-GFCCVEGCSA-N 0.000 claims abstract description 18
- 239000005797 Iprovalicarb Chemical class 0.000 claims abstract description 17
- NWUWYYSKZYIQAE-ZBFHGGJFSA-N L-(R)-iprovalicarb Chemical class CC(C)OC(=O)N[C@@H](C(C)C)C(=O)N[C@H](C)C1=CC=C(C)C=C1 NWUWYYSKZYIQAE-ZBFHGGJFSA-N 0.000 claims abstract description 17
- 239000005807 Metalaxyl Substances 0.000 claims abstract description 17
- ZQEIXNIJLIKNTD-UHFFFAOYSA-N methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate Chemical compound COCC(=O)N(C(C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-UHFFFAOYSA-N 0.000 claims abstract description 17
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 16
- 150000003851 azoles Chemical class 0.000 claims description 81
- 239000005805 Mepanipyrim Substances 0.000 claims description 75
- CIFWZNRJIBNXRE-UHFFFAOYSA-N mepanipyrim Chemical compound CC#CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 CIFWZNRJIBNXRE-UHFFFAOYSA-N 0.000 claims description 75
- 239000002131 composite material Substances 0.000 claims description 50
- 241000233679 Peronosporaceae Species 0.000 claims description 27
- 239000000375 suspending agent Substances 0.000 claims description 25
- JHXVRRJXCDAINK-UHFFFAOYSA-N NC(=O)N.N#CC#N Chemical compound NC(=O)N.N#CC#N JHXVRRJXCDAINK-UHFFFAOYSA-N 0.000 claims description 16
- 239000003094 microcapsule Substances 0.000 claims description 14
- 235000007164 Oryza sativa Nutrition 0.000 claims description 13
- 235000009566 rice Nutrition 0.000 claims description 13
- 239000000839 emulsion Substances 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 9
- 238000009736 wetting Methods 0.000 claims description 9
- 239000000725 suspension Substances 0.000 claims description 7
- 206010039509 Scab Diseases 0.000 claims description 6
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 241000582441 Peronospora tabacina Species 0.000 claims description 5
- 208000010801 foot rot Diseases 0.000 claims description 5
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 5
- 241000607479 Yersinia pestis Species 0.000 claims description 2
- 241000918585 Pythium aphanidermatum Species 0.000 claims 2
- 240000007594 Oryza sativa Species 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract description 23
- 230000000694 effects Effects 0.000 abstract description 5
- 238000001228 spectrum Methods 0.000 abstract description 2
- XERJKGMBORTKEO-VZUCSPMQSA-N (1e)-2-(ethylcarbamoylamino)-n-methoxy-2-oxoethanimidoyl cyanide Chemical class CCNC(=O)NC(=O)C(\C#N)=N\OC XERJKGMBORTKEO-VZUCSPMQSA-N 0.000 abstract 1
- 239000005756 Cymoxanil Chemical class 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 39
- 239000003814 drug Substances 0.000 description 29
- 230000003449 preventive effect Effects 0.000 description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 239000000575 pesticide Substances 0.000 description 15
- 239000013530 defoamer Substances 0.000 description 13
- 239000002270 dispersing agent Substances 0.000 description 13
- 239000012071 phase Substances 0.000 description 13
- 240000008067 Cucumis sativus Species 0.000 description 12
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 12
- 241000209094 Oryza Species 0.000 description 12
- 239000008367 deionised water Substances 0.000 description 11
- 229910021641 deionized water Inorganic materials 0.000 description 11
- 239000003995 emulsifying agent Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 241000233629 Phytophthora parasitica Species 0.000 description 9
- 230000002528 anti-freeze Effects 0.000 description 9
- 239000000080 wetting agent Substances 0.000 description 9
- 239000002562 thickening agent Substances 0.000 description 8
- 231100000820 toxicity test Toxicity 0.000 description 8
- 244000183278 Nephelium litchi Species 0.000 description 7
- 206010067482 No adverse event Diseases 0.000 description 7
- 241000233614 Phytophthora Species 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 206010011732 Cyst Diseases 0.000 description 5
- 208000031513 cyst Diseases 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000227653 Lycopersicon Species 0.000 description 4
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000010165 autogamy Effects 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000003905 agrochemical Substances 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 238000000498 ball milling Methods 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 239000005726 Ametoctradin Substances 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical class BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a high efficient sterilizing composition containing initium. The composition comprises an active component A and an active component B, wherein the active component A is initium, the active component B is selected from one of the following components: metalaxyl, metalaxyl-M, propamocarb, salts of propamocarb, cymoxanil, and iprovalicarb, and the weight ratio of the active component A to the active component B is 1:80 to 60:1. The composition has high activity on a plurality of diseases on a plurality of crops, has prominent synergetic effect at the same time, and thus the bactericidal spectrum is enlarged. Moreover the composition has the characteristics of little use amount, rain washing resistance, and prominent synergetic effect.
Description
Technical field
The invention belongs to technical field of pesticide, relate to the application of a kind of efficient bactericidal composite containing azoles mepanipyrim in crop pest.
Technical background
Azoles mepanipyrim (ametoctradin) is obtained interim registration in China, and azoles mepanipyrim is brand-new triazolo pyrimidine series bactericidal agent, for the downy mildew of prevention and control cucumber and grape crop.
The salt of Propamocarb is propamocarb or Propamocarb second phosphate.
In the real process of agricultural production, preventing and treating the problem that disease the most easily produces is the generation of disease drug resistance.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really have a synergistic effect composite seldom, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor's research, find mutually composite to azoles mepanipyrim and metalaxyl and Metalaxyl-M, Propamocarb and salt thereof, white urea cyanogen, iprovalicarb, there is within the specific limits good synergistic effect, and relevant composite about azoles mepanipyrim and metalaxyl and Metalaxyl-M, Propamocarb and salt thereof, white urea cyanogen, iprovalicarb, there is not yet at present relevant report at home and abroad.
Summary of the invention
The object of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good efficient bactericidal composite containing azoles mepanipyrim.
The present invention is achieved through the following technical solutions:
A kind of efficient bactericidal composite containing azoles mepanipyrim, contain active components A and active component B, active components A and active component B weight ratio are 1: 80～60: 1, described active components A is selected from azoles mepanipyrim, and active component B is selected from the one in metalaxyl and Metalaxyl-M, Propamocarb and salt thereof, white urea cyanogen, iprovalicarb; The weight ratio that is preferably active components A and active component B is 1 ︰ 60～40 ︰ 1; More preferably the weight ratio of azoles mepanipyrim and metalaxyl and Metalaxyl-M is 1: 20～10: 1, the weight ratio of azoles mepanipyrim and Propamocarb and salt thereof is 1: 15～10: 1, the weight ratio of azoles mepanipyrim and white urea cyanogen is 1: 15～15: 1, and the weight ratio of azoles mepanipyrim and iprovalicarb is 1: 10～15: 1.
Bactericidal composition of the present invention, can be processed on demand acceptable formulation in any sterilization, wherein more preferably formulation is wetting powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent, microcapsule suspension-suspending agent, and Metalaxyl-M, propamocarb or Propamocarb second phosphate can also be made aqua.
The disease of the described efficient bactericidal composite containing azoles mepanipyrim for preventing and treating crop; Described crop is cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flowers crop, medicinal crop, raw material crop, green manure pasture crop; Described disease is downy mildew, peronospora tabacina, gray mold, epidemic disease, damping off, damping off, rust, balck shank, foot rot, scab, rice blast, head smut, angular leaf spot or root rot.
The amount of application when content of active component depends on independent use in bactericidal composition of the present invention, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target disease.Conventionally in composition, the weight percentage of active component is gross weight 1%～90%, is preferably 5%～80%.According to different preparation types, active component content scope is different.Liquids in general preparation contains 1%～60% active substance by weight, is preferably 5%～50%; Solid pharmaceutical preparation contains 5%～80% active substance by weight, is preferably 10%～80%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 2%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
Bactericidal composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by processing method known in those skilled in the art, after mixing with liquid flux or solid carrier by active component, then add surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, disintegrant, defoamer etc.According to different dosage form, in preparation, can also contain antifreeze known in those skilled in the art etc.
When making wetting powder, composition comprises following component and content: active components A 0.5% ~ 60%, active component B0.5% ~ 80%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, filler surplus.
When making water dispersible granules, composition comprises following component and content: active components A 0.5% ~ 60%, active component B0.5% ~ 80%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%, binding agent 0 ~ 8%, filler surplus.
When making suspending agent, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, dispersant 1% ~ 10%, wetting agent 1% ~ 10%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
When making aqueous emulsion, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, solvent 1% ~ 20%, emulsifier 1% ~ 12%, antifreeze 0 ~ 8%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, deionized water add to 100%.
When making microemulsion, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, emulsifier 3% ~ 25%, solvent 1% ~ 10%, antifreeze 0 ~ 8%, defoamer 0.01% ~ 2%, deionized water add to 100%.
When making suspension emulsion, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, emulsifier 1% ~ 10%, dispersant 1% ~ 10%, solvent 1% ~ 20%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
When making microcapsule suspending agent, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, macromolecule cyst material 1% ~ 10%, dispersant 2% ~ 10%, solvent 1% ~ 10%, emulsifier 1% ~ 7%, pH adjusting agent 0.01% ~ 5%, defoamer 0.01% ~ 2%, deionized water add to 100%.
When making microcapsule suspension-suspending agent, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, macromolecule cyst material 1% ~ 12%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, solvent 1% ~ 15%, emulsifier 1% ~ 8%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspending agent the key technical indexes of the present invention:
The invention has the advantages that:
(1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose; (2) agricultural chemicals dosage reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmental pollution; (3) expanded fungicidal spectrum, multiple diseases has been had to greater activity as downy mildew, peronospora tabacina, gray mold, epidemic disease, damping off, damping off, rust, balck shank, foot rot, scab, rice blast, head smut, angular leaf spot, root rot etc.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Embodiment 1～15 wetting powder
Azoles mepanipyrim, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into wetting powder product of the present invention.Specifically in table 1.
The each component of table 1 embodiment 1～15 and content
Embodiment 16～30 water dispersible granules
Azoles mepanipyrim, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, then add other auxiliary agents such as binding agent (can add and can not add), obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, can make water dispersible granules product of the present invention, specifically in table 2.
The each component of table 2 embodiment 16～30 and content
Embodiment 31～45 suspending agents
By dispersant, wetting agent, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), mix through high speed shear, add azoles mepanipyrim, active component B, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μ m, surplus is supplied by deionized water, can make suspending agent product of the present invention, specifically in table 3.
The each component of table 3 embodiment 31～45 and content
Embodiment 46～56 aqueous emulsions
Azoles mepanipyrim, active component B, solvent, emulsifier are added together, make to be dissolved into even oil phase; Deionized water, antifreeze (can add and can not add), thickener (can add and can not add), defoamer are mixed, become homogeneous water.Under high-speed stirred, water is added to oil phase, make aqueous emulsion product of the present invention.Specifically in table 4.
The each component of table 4 embodiment 46～56 and content
Embodiment 57～67 microemulsions
Azoles mepanipyrim, active component B are dissolved in the homogenizer that solvent is housed, by emulsifier, antifreeze (can add and can not add), defoamer, join in the homogenizer that above-mentioned solution is housed, surplus gives strong mixing and homogenize after supplying by deionized water, finally obtain the as clear as crystal microemulsion product of the present invention of outward appearance.Specifically in table 5.
The each component of table 5 embodiment 57～67 and content
Metalaxyl in table 1 ~ 5 or Metalaxyl-M, Propamocarb and salt thereof, white urea cyanogen, iprovalicarb are exchanged, can make novel formulation.
Embodiment 68～70 suspension emulsions
Dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add) are mixed through high speed shear, add azoles mepanipyrim, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μ m, make azoles mepanipyrim suspending agent, then by active component B, emulsifier, solvent and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make suspension emulsion product of the present invention.Specifically in table 6.
The each component of table 6 embodiment 68～70 and content
Embodiment 71～73 microcapsule suspending agents
By azoles mepanipyrim, active component B, macromolecule cyst material, solvent, make to be dissolved into even oil phase, under shearing condition, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent, dispersant, defoamer, surplus is supplied by deionized water, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically in table 7.
The each component of table 7 embodiment 71～73 and content
Embodiment 74～76 microcapsule suspensions-suspending agent
By active component B, macromolecule cyst material, solvent, make to be dissolved into even oil phase, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent under shearing condition, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add azoles mepanipyrim, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μ m, make suspending agent, then suspending agent is joined in the aqueous phase solution of micro-capsule suspension, deionized water is supplied surplus, makes the finely disseminated microcapsule suspension-suspending agent of present composition product.Specifically in table 8.
The each component of table 8 embodiment 74～76 and content
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carries out field trial.
Test method: after the effective inhibition concentration scope of each medicament is determined in prerun, medicament is established respectively 5 dosage processing by active constituent content, establishes clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure the virulence of medicament to crop germ.After 72h, measure colony diameter by right-angled intersection method, calculate each processing net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value to (x), tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50value.Calculate the different proportioning synergy ratios of two medicaments (SR) according to Wadley method, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and active component B shared ratio in combination;
A is azoles mepanipyrim;
B is selected from the one in metalaxyl and Metalaxyl-M, Propamocarb and salt thereof, white urea cyanogen or iprovalicarb.
Application Example two:
For examination disease: cucumber downy mildew, test medicine provides by Shanxi Thompson Biological Technology Co., Ltd., experimental scheme: effective inhibition concentration scope of determining azoles mepanipyrim and metalaxyl or the two different proportioning mixture of Metalaxyl-M through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to cucumber downy mildew of table 9 azoles mepanipyrim and metalaxyl or Metalaxyl-M
As shown in Table 9, the proportioning of the composite control cucumber downy mildew of azoles mepanipyrim and metalaxyl or Metalaxyl-M is in the time of 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 80 ~ 60 ︰ 1 scopes, the proportioning of azoles mepanipyrim and metalaxyl or Metalaxyl-M was at 1: 20～10: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Test and find that the proportioning of azoles mepanipyrim and metalaxyl or Metalaxyl-M is 10 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰ 15,1 ︰ 20 through applicant, synergy ratio maximum when wherein azoles mepanipyrim and metalaxyl and Metalaxyl-M weight ratio are 1:5, synergistic effect is the most obvious.
Application Example three:
For examination disease: cucumber downy mildew, test medicine provides by Shanxi Thompson Biological Technology Co., Ltd., experimental scheme: effective inhibition concentration scope of determining azoles mepanipyrim and Propamocarb and the former medicine of salt and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to cucumber downy mildew of table 10 azoles mepanipyrim and Propamocarb and salt thereof
As shown in Table 10, the proportioning of the composite control cucumber downy mildew of azoles mepanipyrim and Propamocarb and salt thereof is in the time of 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 80 ~ 60 ︰ 1 scopes, the proportioning of azoles mepanipyrim and Propamocarb and salt thereof was at 1: 15～10: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Test and find that the proportioning of azoles mepanipyrim and Propamocarb and salt thereof is 10 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰ 15 through applicant, synergy ratio maximum when wherein azoles mepanipyrim and Propamocarb and salt weight ratio thereof are 1:3, synergistic effect is the most obvious.
Application Example four:
For examination disease: peronophythora litchi, test medicine provides by Shanxi Thompson Biological Technology Co., Ltd., experimental scheme: effective inhibition concentration scope of determining azoles mepanipyrim and the former medicine of white urea cyanogen and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to peronophythora litchi of table 11 azoles mepanipyrim and white urea cyanogen
As shown in Table 11, the proportioning of azoles mepanipyrim and the composite control peronophythora litchi of white urea cyanogen is in the time of 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 80 ~ 60 ︰ 1 scopes, the proportioning of azoles mepanipyrim and white urea cyanogen was at 1: 15～15: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Test and find that the proportioning of azoles mepanipyrim and white urea cyanogen is 15 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 15 through applicant, synergy ratio maximum when wherein azoles mepanipyrim and white urea cyanogen weight ratio are 1:1, synergistic effect is the most obvious.
Application Example five:
For trying disease: downy mildew of garpe, test medicine provides by Shanxi Thompson Biological Technology Co., Ltd., experimental scheme: effective inhibition concentration scope of determining the former medicine of azoles mepanipyrim and iprovalicarb and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to downy mildew of garpe of table 12 azoles mepanipyrim and iprovalicarb
As shown in Table 12, the composite proportioning of preventing and treating downy mildew of garpe of azoles mepanipyrim and iprovalicarb is in the time of 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 80 ~ 60 ︰ 1 scopes, the proportioning of azoles mepanipyrim and iprovalicarb was at 1: 10～15: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Test and find that the proportioning of azoles mepanipyrim and iprovalicarb is 15 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10 through applicant, synergy ratio maximum when wherein azoles mepanipyrim and iprovalicarb weight ratio are 3:2, synergistic effect is the most obvious.
Find through test: after azoles mepanipyrim and active component B are composite, the control of the downy mildew in various crop, peronospora tabacina, gray mold, epidemic disease, damping off, damping off, rust, balck shank, foot rot, scab, rice blast, head smut, angular leaf spot, root rot is had to obvious synergistic effect, synergy ratio is all more than 1.5.
Effect experiment part: test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 20% azoles mepanipyrim suspending agent (autogamy), 25% metalaxyl wetting powder (commercial) (20% Metalaxyl-M wetting powder (autogamy)), 35% Propamocarb aqua (35% propamocarb aqua) (commercial), 20% white urea cyanogen suspending agent (autogamy), 40% iprovalicarb wetting powder (autogamy).
Application Example six azoles mepanipyrims and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
This experimental establishment, in Jingyang County, Shaanxi Province, is investigated the cucumber downy mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 13 azoles mepanipyrim and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 13, azoles mepanipyrim and active component B and composite after can effectively prevent and treat cucumber downy mildew, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Gray mold of cucumber, scab, damping off are also had to good preventive effect, preventive effect is up to more than 96% simultaneously.
Application Example seven azoles mepanipyrims and active component B and the composite control tomato blight test of pesticide effectiveness thereof
This test arrangement, in Xi'an City, Shanxi Province, is investigated the tomato blight state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 3 days, 7 days, 15 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 14 azoles mepanipyrim and active component B and the composite control tomato blight test of pesticide effectiveness thereof
As can be seen from Table 14, azoles mepanipyrim and active component B and composite after can effectively prevent and treat tomato blight, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long, target crop is had no adverse effects in scope of medication in test.
Application Example eight azoles mepanipyrims and active component B and the composite control rice seedling blight test of pesticide effectiveness thereof
This test arrangement, at Shaanxi Province's Hanzhong City, is investigated the rice seedling blight state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 15 azoles mepanipyrim and active component B and the composite control rice seedling blight test of pesticide effectiveness thereof
As can be seen from Table 15, azoles mepanipyrim and active component B and composite rear efficiency control rice seedling blight thereof, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example nine azoles mepanipyrims and active component B and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
This test arrangement, at Shaanxi Province's Weinan City, is investigated the downy mildew of garpe state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 16 azoles mepanipyrim and active component B and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 16, azoles mepanipyrim and active component B and composite after can effectively prevent and treat downy mildew of garpe, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten azoles mepanipyrims and active component B and the composite control rice blast test of pesticide effectiveness thereof
This test arrangement, at Shaanxi Province's Hanzhong City, is investigated the rice blast state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 17 azoles mepanipyrim and active component B and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 17, azoles mepanipyrim and active component B and composite after can effectively prevent and treat rice blast, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 11 azoles mepanipyrims and active component B and the composite control peronophythora litchi test of pesticide effectiveness thereof
This test arrangement, in Zengcheng City of Guangdong Province, is investigated the peronophythora litchi state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 18 azoles mepanipyrim and active component B and the composite control peronophythora litchi test of pesticide effectiveness thereof
As can be seen from Table 18, azoles mepanipyrim and active component B and composite after can effectively prevent and treat peronophythora litchi, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten diazole mepanipyrims and active component B and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
This test arrangement, at Shaanxi Province's Weinan City, is investigated the downy mildew of garpe state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 19 azoles mepanipyrim and active component B and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 19, azoles mepanipyrim and active component B and composite rear efficiency thereof are prevented and treated downy mildew of garpe, and control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After draw through different local throughout the country tests, azoles mepanipyrim and metalaxyl, Metalaxyl-M, Propamocarb and salt thereof, white urea cyanogen, iprovalicarb composite rear to the preventive effect of the Common Diseases such as the downy mildew in various crop, peronospora tabacina, gray mold, epidemic disease, damping off, damping off, rust, balck shank, foot rot, scab, rice blast, head smut, angular leaf spot or root rot all 95% with on excellent, in single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. the efficient bactericidal composite containing azoles mepanipyrim, effective active composition is active components A and active component B, it is characterized in that: the weight ratio of active components A and active component B is 1: 80～60: 1, described active components A is selected from azoles mepanipyrim, and active component B is selected from the one in metalaxyl and Metalaxyl-M, Propamocarb and salt thereof, white urea cyanogen or iprovalicarb.
2. the efficient bactericidal composite containing azoles mepanipyrim according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1: 60～40: 1.
3. the efficient bactericidal composite containing azoles mepanipyrim according to claim 2, is characterized in that:
The weight ratio of azoles mepanipyrim and metalaxyl and Metalaxyl-M is 1: 20～10: 1;
The weight ratio of azoles mepanipyrim and Propamocarb and salt thereof is 1: 15～10: 1;
The weight ratio of azoles mepanipyrim and white urea cyanogen is 1: 15～15: 1;
The weight ratio of azoles mepanipyrim and iprovalicarb is 1: 10～15: 1.
4. according to the efficient bactericidal composite containing azoles mepanipyrim described in any one in claim 1～3, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent or microcapsule suspension-suspending agent.
5. the efficient bactericidal composite containing azoles mepanipyrim according to claim 4 is for preventing and treating the purposes of crop pest.
6. purposes according to claim 5, is characterized in that: described disease is downy mildew, peronospora tabacina, gray mold, epidemic disease, damping off, damping off, rust, balck shank, foot rot, scab, rice blast, head smut, angular leaf spot or root rot.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210559646.4A CN103875684A (en) | 2012-12-20 | 2012-12-20 | High efficient sterilizing composition containing initium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210559646.4A CN103875684A (en) | 2012-12-20 | 2012-12-20 | High efficient sterilizing composition containing initium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103875684A true CN103875684A (en) | 2014-06-25 |
Family
ID=50945072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210559646.4A Pending CN103875684A (en) | 2012-12-20 | 2012-12-20 | High efficient sterilizing composition containing initium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103875684A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104621157A (en) * | 2015-02-04 | 2015-05-20 | 河南科技学院 | Cyprodinil and iprovalicarb containing sterilizing composition and application thereof |
| CN104782640A (en) * | 2015-05-05 | 2015-07-22 | 河南科技学院 | Fungicidal composition containing iprovalicarb and fluoxastrobin and use of bactericidal composition |
| CN105379725A (en) * | 2015-11-06 | 2016-03-09 | 南京华洲药业有限公司 | Sterilizing composition containing mepanioyrim and metalaxyl and application thereof |
| CN105394060A (en) * | 2015-11-06 | 2016-03-16 | 南京华洲药业有限公司 | Sterilization composition containing mepanipyrim and propamocarb and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101232814A (en) * | 2005-07-27 | 2008-07-30 | 巴斯福股份公司 | Fungicidal mixtures based on azolopyrimidinylamines |
-
2012
- 2012-12-20 CN CN201210559646.4A patent/CN103875684A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101232814A (en) * | 2005-07-27 | 2008-07-30 | 巴斯福股份公司 | Fungicidal mixtures based on azolopyrimidinylamines |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104621157A (en) * | 2015-02-04 | 2015-05-20 | 河南科技学院 | Cyprodinil and iprovalicarb containing sterilizing composition and application thereof |
| CN104782640A (en) * | 2015-05-05 | 2015-07-22 | 河南科技学院 | Fungicidal composition containing iprovalicarb and fluoxastrobin and use of bactericidal composition |
| CN105379725A (en) * | 2015-11-06 | 2016-03-09 | 南京华洲药业有限公司 | Sterilizing composition containing mepanioyrim and metalaxyl and application thereof |
| CN105394060A (en) * | 2015-11-06 | 2016-03-16 | 南京华洲药业有限公司 | Sterilization composition containing mepanipyrim and propamocarb and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103843826A (en) | Fungicidal composition containing alternaria tenuissima-activated protein | |
| CN103461339A (en) | Fluopicolide-containing sterilization composition | |
| CN103651467B (en) | A kind of bactericidal composition containing Hexanaphthene flusulfamide | |
| CN103651538B (en) | A kind of bactericidal composition containing zoxamide | |
| CN103875684A (en) | High efficient sterilizing composition containing initium | |
| CN103563960B (en) | A kind of bactericidal composition | |
| CN104336038A (en) | Compound sterilization composition containing oxathiapiprolin | |
| CN104336049A (en) | A sterilization composition containing oxathiapiprolin | |
| CN104336024A (en) | Bactericidal composition containing fluorothiazolepyrithylone and amides | |
| CN103891739B (en) | A kind of bactericidal composition containing azoles mepanipyrim and amide-type | |
| CN103798272A (en) | Bactericidal composition containing pyraclostrobin and moroxydine hydrochloride | |
| CN103518741A (en) | Fluopyram-containing high-efficiency bactericidal composition | |
| CN103704229B (en) | Bactericidal composition containing fluorine azole activated ester | |
| CN103518727B (en) | A kind of bactericidal composition of containing fluopyram | |
| CN103621550B (en) | Chesulfamide-containing pesticide composition | |
| CN103843790A (en) | Fungicidal composition containing ametoctradin | |
| CN103651417A (en) | Bactericidal composition containing zoxamide and methoxyacrylate | |
| CN104642339A (en) | High-efficient sterilization composition containing thiazole zinc | |
| CN104336027A (en) | Pesticide composition containing fluorothiazole pyrithylone | |
| CN104336040A (en) | An efficient sterilization composition containing oxathiapiprolin | |
| CN103583536A (en) | Pesticide composition | |
| CN103583562A (en) | An efficient sterilization composition containing hexamethylene flusulfamide | |
| CN103621515B (en) | Chesulfamide-containing pesticide composition | |
| CN103875685B (en) | A kind of bactericidal composition containing azoles mepanipyrim | |
| CN104430462A (en) | Xiaobenjun'an-containing compounded sterilization composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140625 |
|
| RJ01 | Rejection of invention patent application after publication |