CN1038181C - One-step process for producing polyvinyl pyrrolidone-iodine aerosol - Google Patents
One-step process for producing polyvinyl pyrrolidone-iodine aerosol Download PDFInfo
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- CN1038181C CN1038181C CN94114287A CN94114287A CN1038181C CN 1038181 C CN1038181 C CN 1038181C CN 94114287 A CN94114287 A CN 94114287A CN 94114287 A CN94114287 A CN 94114287A CN 1038181 C CN1038181 C CN 1038181C
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- aerosol
- iodine
- complexation
- ethanol
- polyvinylpyrrolidone
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Abstract
The present invention relates to a one-step method for producing a polyvinylpyrrolidone-iodine solution aerosol. Polyvinylpyrrolidone and iodine are respectively dissolved in ethanol, and are placed in a complexation pot, and water-insoluble carriers and isopropyl ethanol are added after heating, refluxing and complexing, so the aerosol is obtained through filtration and split charging. The aerosol produced by the method has the advantages for decreasing investment cost for equipment by 50%, saving 75% of energy consumption, increasing 6 to 7 times of productive efficiency and raising the stability of the aerosol, and the aerosol can quickly form a disinfection film to ensure disinfection quality.
Description
The present invention relates to a kind of production method of polyvinyl pyrrolidone-iodine aerosol.
Povidon iodine was succeeded in developing by Beller etc. in nineteen fifty-five, and by German BasF company at first Application and Development recorded by state's pharmacopeia such as American and Britain, morals so far in clinical, in 1990 two ones of version of China's pharmacopeia is also recorded.This medicine belongs to second filial generation Operand, the sterilizing effect is strong, long action time, nontoxic, non-stimulated, safe and reliable, replaced other disinfectant abroad gradually, be widely used in the sterilization of skin, mucosa, wound, body cavity, its dosage form has aqueous pharmaceutical, aerosol abroad, contains the agent of coughing, ointment, gel, suppository etc., and China has recorded solution, ointment, suppository.Aerosol can be advantageously used in the sterilization of skin, mucosa, wound, can locally form uniform betadin thin film after the use, plays a protective role.
At present, the conventional production methods of polyvinyl pyrrolidone-iodine aerosol, be that polyvinylpyrrolidone and iodine are used chloroform (or ethanol) dissolving respectively, in the complexation still, carry out complexation, reclaim chloroform or ethanol blowing then, the dense magma of povidon iodine is put porcelain dish, through the vacuum drying oven drying, pulverize, get crude drug.Utilize carrier solvents such as water, ethanol, propylene glycol that crude drug is dissolved then, carry out ingredients again, stir evenly, filter packing.Obviously, existing production method complex manufacturing, use equipment is many, and energy consumption is big.
The object of the present invention is to provide a kind of one-step process for producing, save vacuum drying, solvent recovery and treatment facility, and reduce production process and equipment investment and save the energy.
Technical solution of the present invention in order to achieve the above object realizes in the following way.Polyvinylpyrrolidone and iodine are used dissolve with ethanol respectively, and it is complete to complexation to put complexation still reflux, and add the carrier fluid isopropyl alcohol afterwards and stir evenly, after filtration, packing.
Characteristics of the present invention are from throwing raw material, finishing in a complexation still continuously through complexation, ingredients.In order to realize this one-step method process route, the carrier intersolubility that solvent that uses in the time of just must making complexation and aerosol use is good, and carrier must guarantee that also the effective ingredient povidon iodine of aerosol has best stability.To the codissolved solvent of complexation material polyethylene ketopyrrolidine and iodine select ethanol and chloroform all can, but consider again can with the mutual coordination of carrier, so adopt ethanol to do complexing solvent.
Adopt water-insoluble isopropyl alcohol to do carrier on the other hand, under the lucifuge condition, make povidon iodine can obtain good stable, and muddy property of isopropyl alcohol is good, form mocromembrane sterilization face very soon, thereby guarantee reliable Disinfection Effect when shortening disinfecting time at skin surface.
This one-step process for producing is compared with traditional production method and is had the following advantages:
1, this production technology is saved vacuum drying, solvent recovery and treatment facility, therefore, can reduce equipment investment 50%.
2, this method only needs 8～10 hours from being dosed into finished product, and traditional handicraft needs 2～3 days, and production efficiency can improve 6～7 times.
3, because of saving the vacuum drying operation, this method only needs the energy consumption of traditional method 1/4.
4, this method adopts isopropyl alcohol to do carrier, does the carrier liquid medicine stability than water or ethanol and is much improved, and this product is deposited (lucifuge, sealing) naturally and only fallen 10% in 2 years, and under the same conditions with water, ethanol be carrier its degrade more than 40% 18% respectively.
5, medicinal liquid of the present invention is sprayed on skin surface, forms rapidly the sterilization mocromembrane in 25～50 seconds, and water to be the aerosol of carrier formed the sterilization mocromembrane through 3～6 minutes, the aerosol of ethanol carrier needed 45～90 seconds to form the sterilization mocromembrane, so this product has improved sterilisation quality.
Further specify technical solution of the present invention in conjunction with the embodiments.
1, with polyvinylpyrrolidone and ethanol with 4.5～5: the ratio of 1 (weight ratio) drops in the complexation still, starts agitator, is heated to polyvinylpyrrolidone all after the dissolving, stops heating its temperature is reduced to below 65 ℃.
2, then with iodine: the dissolved iodohydrin liquid of ethanol=1: 4.8～5.2 ratios is to be heated to backflow in 4.88～4.8: the 1 adding complexation still by the rate of charge of polyvinylpyrrolidone and iodine, refluxed 3～4 hours, extracting backflow does not have pink to be faint yellow is that complexation is finished, and stops heating.
3, complex is cooled to 35～40 ℃ naturally after, the isopropyl alcohol that adds 100 times of povidon iodine amounts (weight) stirs evenly, and filters packing.
Claims (1)
1, a kind of one-step process for producing polyvinyl pyrrolidone-iodine aerosol, polyvinylpyrrolidone and iodine are used dissolve with ethanol respectively, put in the complexation still and heat, be back to the extraction backflow and be faint yellow, make complexation complete, it is characterized in that: after complex was reduced to 35～40 ℃ naturally, the isopropyl alcohol that adds 100 times of povidon iodine weight stirred evenly, and packing after filtering gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94114287A CN1038181C (en) | 1994-12-28 | 1994-12-28 | One-step process for producing polyvinyl pyrrolidone-iodine aerosol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94114287A CN1038181C (en) | 1994-12-28 | 1994-12-28 | One-step process for producing polyvinyl pyrrolidone-iodine aerosol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1108928A CN1108928A (en) | 1995-09-27 |
| CN1038181C true CN1038181C (en) | 1998-04-29 |
Family
ID=5037178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94114287A Expired - Fee Related CN1038181C (en) | 1994-12-28 | 1994-12-28 | One-step process for producing polyvinyl pyrrolidone-iodine aerosol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1038181C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI289511B (en) | 2004-11-22 | 2007-11-11 | Canon Kk | Method of manufacturing liquid discharge head, and liquid discharge head |
| CN111358807B (en) * | 2020-04-01 | 2021-04-13 | 赵莹 | Nano-silver modified complex iodine composite dry powder disinfection aerosol and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0342269A2 (en) * | 1988-05-20 | 1989-11-23 | Sunstar Kabushiki Kaisha | Iodine microbiocide composition |
-
1994
- 1994-12-28 CN CN94114287A patent/CN1038181C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0342269A2 (en) * | 1988-05-20 | 1989-11-23 | Sunstar Kabushiki Kaisha | Iodine microbiocide composition |
Non-Patent Citations (1)
| Title |
|---|
| 《药剂辅料大全》第一版 1993.3.1 罗明生，高天惠主编;四川科技出版社 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1108928A (en) | 1995-09-27 |
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| C14 | Grant of patent or utility model | ||
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| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |