CN103751558B - A kind of compound antihypelipidemic pill and preparation method thereof - Google Patents
A kind of compound antihypelipidemic pill and preparation method thereof Download PDFInfo
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- CN103751558B CN103751558B CN201410034620.7A CN201410034620A CN103751558B CN 103751558 B CN103751558 B CN 103751558B CN 201410034620 A CN201410034620 A CN 201410034620A CN 103751558 B CN103751558 B CN 103751558B
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of compound antihypelipidemic pill and preparation method thereof, using Fructus Momordicae charantiae, Radix Momordicae Charantiae, Radix Et Rhizoma Fagopyri Tatarici, Cordyceps militaris (L.) Link., Ganoderma spore powder, the Radix Astragali, Radix Trichosanthis, the Rhizoma Anemarrhenae, Semen Cassiae, Fructus Lycii, Radix Sophorae Flavescentis, Radix Ophiopogonis, Semen Lablab Album, Radix Ginseng, Radix Glycyrrhizae and Herba Dendrobii as formula material, the obtained finished product of packaging after pulverizing, lixiviate, concentrated, mixing, rubbing become ball, airing.The present invention uses tradition and modern Chinese medicine theory, according to Fructus Momordicae charantiae, Radix Momordicae Charantiae, Ganoderma spore powder, the result of study of the modern pharmacology such as Cordyceps militaris (L.) Link. and Herba Dendrobii pharmacodynamics, with pure natural medical compatibility, scientific composition, advanced technologies, the compound antihypelipidemic pill developed not only has significant reduction blood glucose function, the polydipsia that obvious alleviation causes because of diabetes, polyuria, polyphagia, become thin and the symptom such as fatigue and weak, and there is strengthening the body resistance, benefiting QI and nourishing blood and immunoregulatory health care prophylactic function, carry in addition simultaneously and store feature easily, be applicable to diabetics long-term taking.
Description
Technical field
The present invention is specifically related to a kind of compound antihypelipidemic ball and preparation method thereof.
Background technology
Diabetes be one group caused by body defect of insulin secretion and/or insulin action obstacle, take hyperglycemia as the metabolic disease of principal character.Persistent high blood sugar and long-term metabolic disorder etc. can cause body tissue's organ, particularly to eye, kidney, cardiovascular and neural infringement and dysfunction thereof and exhaustion, severe patient can cause dehydration, the acute complications such as electrolyte disturbance and acid base imbalance, ketoacidosis and Hyperosmotic coma.In addition, no matter be type Ⅰ diabetes mellitus or type Ⅱdiabetes mellitus, all need long-term treatment, bring huge misery and heavy financial burden to patient and family members thereof.
China is one of diabetes country occurred frequently, has diabetics about 100,000,000, therefore how to reduce blood glucose, controls and one of problem that the various symptoms that diabetes-alleviating causes are modern people to be paid close attention to the most.Much prevent, treat diabetes or fall hypoglycemic medicines and health protection product although existing on market, great majority are chemicals or insulin type hormone, all have untoward reaction in various degree, and little with the compound antihypelipidemic product of pure natural medical compatibility.
Summary of the invention
The object of the present invention is to provide a kind of compound antihypelipidemic ball and preparation method thereof, with pure natural medical compatibility, scientific composition, advanced technologies, the compound antihypelipidemic pill developed not only has significant reduction blood glucose function, also obviously can alleviate polydipsia, polyuria, polyphagia because diabetes cause, become thin and the symptom such as fatigue and weak, be applicable to diabetics long-term taking.
For achieving the above object, the present invention adopts following technical scheme:
A kind of compound antihypelipidemic pill, its raw material composition comprises: Fructus Momordicae charantiae, Radix Momordicae Charantiae, Radix Et Rhizoma Fagopyri Tatarici, Cordyceps militaris (L.) Link., Ganoderma spore powder, the Radix Astragali, Radix Trichosanthis, the Rhizoma Anemarrhenae, Semen Cassiae, Fructus Lycii, Radix Sophorae Flavescentis, Radix Ophiopogonis, Semen Lablab Album, Radix Ginseng, Radix Glycyrrhizae and Herba Dendrobii.
The percentage by weight of each raw material is: Fructus Momordicae charantiae 10-30%, Radix Momordicae Charantiae 5-20%, Radix Et Rhizoma Fagopyri Tatarici 10-30%, Cordyceps militaris (L.) Link. 5-20%, Ganoderma spore powder 5-20%, Radix Astragali 5-20%, Radix Trichosanthis 1-5%, Rhizoma Anemarrhenae 1-5%, Semen Cassiae 1-5%, Fructus Lycii 1-3%, Radix Sophorae Flavescentis 1-5%, Radix Ophiopogonis 1-3%, Semen Lablab Album 1-5%, Radix Ginseng 1-5%, Radix Glycyrrhizae 1-3%, Herba Dendrobii 1-5%, the percentage by weight sum of above-mentioned each raw material is 100%.
The preparation method of described compound antihypelipidemic pill, its concrete steps are as follows:
1), pulverize: Ganoderma spore powder is carried out wall breaking pulverization, obtains Ganoderma spore powder with cellular wall broken for subsequent use; Cordyceps militaris (L.) Link., Semen Cassiae and Herba Dendrobii are carried out micronizing respectively, obtains Cordyceps militaris (L.) Link. powder, Semen Cassiae powder and dendrobium officinale powder for subsequent use; Radix Et Rhizoma Fagopyri Tatarici being fried to tendering with a crispy crust, pulverizing 100 mesh sieves, and obtaining Radix Et Rhizoma Fagopyri Tatarici powder for subsequent use;
2), lixiviate: it is 60%-90% alcoholic solution that Fructus Momordicae charantiae and Radix Momordicae Charantiae are added mass fraction by mass volume ratio 1:4 ~ 8, reflux, extract, 0.5-1.5 hour, collect ethanol extract a, and then add water by mass volume ratio 1:4 ~ 8, hot water return lixiviate 2 times, Extracting temperature 100 DEG C, each 0.5-1.5 hour, collects extracting solution b; Decoct with water 2 times by mass volume ratio 1:4 ~ 8, each 0.5-1.5 hour by after the Radix Astragali, Radix Trichosanthis, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Sophorae Flavescentis, Radix Ophiopogonis, Semen Lablab Album, Radix Ginseng and Radix Glycyrrhizae mixing, decoct temperature 100 DEG C, collect extracting solution c;
3), concentrated: extracting solution a, b and c are mixed, adopt 60000Da ultrafilter membrane 40-60 DEG C, filter under 0.30-0.40MPa pressure, concentrated, obtain the concentrated solution that relative density is 1.05-1.10;
4), mix: the Radix Et Rhizoma Fagopyri Tatarici powder added respectively in concentrated solution, Ganoderma spore powder with cellular wall broken, Cordyceps militaris (L.) Link. powder, Semen Cassiae powder and dendrobium officinale powder, mix homogeneously also rubs into dough sample soft material;
5), rubbing becomes ball: dough sample soft material is placed 20-30 minute, after spice to mix with Radix Et Rhizoma Fagopyri Tatarici powder and produces viscosity, rub with hand pellet processing machine that thickness is consistent, the strip of smooth in appearance, then make smooth, the spherical pill in garden with pellet processing machine, every heavy 0.1-0.3g of ball;
6), airing: ready-made pill is placed on after drying in the dry place of room ventilation or low temp. sterilizing case and packs again.
The present invention adopts natural medicinal plant to carry out compatibility preparation, and its pharmacologic agent mechanism of action is:
Fructus Momordicae charantiae: cold in nature, bitter in the mouth; GUIXIN, spleen, lung meridian; Have clearing away summer-heat to wash the effects such as heat, improving eyesight, removing toxic substances, for summer-heat excessive thirst, quench one's thirst, the disease such as acute conjunctivitis pain.Modern study shows, Fructus Momordicae charantiae crude extract has the effect of significant reduction blood glucose, radioimmunology detects and finds that Fructus Momordicae charantiae extract and Insulin receptor INSR, insulin antibody all have obvious association reaction, show that it and islets of langerhans have common antigenicity and biological activity, therefore Fructus Momordicae charantiae crude extract has the effect of similar insulin.
Radix Momordicae Charantiae: cold in nature, bitter in the mouth; There is the effect such as clearing away damp-heat, removing toxic substances, for the disease such as damp-heat dysentery, acute toothache.Modern study shows, Radix Momordicae Charantiae contains the composition promoting insulin secretion, the effect have assist control blood glucose, preventing diabetes.
Cordyceps militaris (L.) Link.: modern study shows, Cordyceps militaris (L.) Link. has strengthening the body resistance, improves effect of liver detoxification ability and balance adjustment negative and positive, has good blood sugar lowering and improves the effect of kidney filtering function.
Ganoderma spore powder: modern study shows, Ganoderma spore powder all has good regulating action to immune system, nervous system, E&M system and cardiovascular system etc., ganoderan in Ganoderma spore powder can strengthen immune function, stimulate the secretion of insulin, fall hypoglycemic concentration, Ganoderma spore powder effectively can improve the blood circulation of pancreas, thus improves the physiological function of pancreas, reduce blood glucose, improve the symptom of diabetes patient.
The Radix Astragali: warm in nature, sweet in the mouth; Return lung, spleen channel; There is the effect such as invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation,, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis weak for the deficiency of vital energy, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, blood deficiency dull yellowish colored skin, interior-heat such as to be quenched one's thirst the disease, clinical in chronic nephritis proteinuria and diabetes.Modern study shows, the Radix Astragali by increasing glycogen synthase activity, IRS activity, protein kinase B and protein kinase C activity, thus playing increase body insulin sensitivity, falling hypoglycemic effect.
Radix Et Rhizoma Fagopyri Tatarici: property is put down, bitter in the mouth; There is effect of physical strength profiting, continuous spirit, sharp knowledge, sending down the abnormal ascending QI, wide intestinal stomach invigorating.Modern study shows, Radix Et Rhizoma Fagopyri Tatarici can reduce fasting glucose, raises insulin level, reduce glycolated hemoglobin and glycated serum protein, reduction blood fat, thus suppresses the development of diabetes and complication thereof, is the Major Nutrient food of diabetes.
Radix Trichosanthis: cold nature, sweet in the mouth, micro-hardship; Attach to the lung and stomach meridians; There are clearing away heat and promoting production of body fluid, moistening the lung and resolving phlegm, detumescence row effect such as dense, the quench one's thirst disease such as polydipsia, lung-heat type cough thirsty for calentura.Modern study also shows that Radix Trichosanthis has clear and definite hypoglycemic activity.
The Rhizoma Anemarrhenae: cold in nature, bitter in the mouth; Return lung, stomach, kidney channel; There are clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, effects such as relieving restlessness of quenching the thirst; For the hot excessive thirst of height, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, the diseases such as stranguria with turbid discharge of quenching one's thirst.Modern study shows, the Rhizoma Anemarrhenae total phenols contained by it has good hypoglycemic activity.
Semen Cassiae: cold nature is sweet in the mouth, hardship, salty; Return liver, large intestine channel; There is the effect such as clearing away heat to improve acuity of vision, loosening bowel to relieve constipation, for the puckery pain of conjunctival congestion, the many tear of photophobia, dizzy, the disease such as poor vision, constipation of having a headache.Modern study shows, Semen Cassiae has obvious therapeutical effect to diabetic nephropathy (DN), effectively can correct the disorders of lipid metabolism of diabetics, alleviate kidney of diabetic patients fibrosis.
Fructus Lycii: property is put down, sweet in the mouth; Return liver, kidney channel; There is the effect such as nourishing the liver and kidney, replenishing vital essence to improve eyesight, for asthenia damage of essence, soreness of waist and knee joint, the disease such as vertigo and tinnitus, interior-heat are quenched one's thirst, blood deficiency and yellow complexion, blurred vision are not clear.Modern study shows, Fructus Lycii has the effect of protection islet beta cell function in early days in diabetes, and the lycium barbarum polysaccharide contained by it also plays hypoglycemic effect by protection beta Cell of islet and increase insulin sensitivity dual function.
Radix Sophorae Flavescentis: cold in nature, bitter in the mouth; GUIXIN, liver, stomach, large intestine, urinary bladder channel; There is the effect such as heat clearing and damp drying, parasite killing, diuresis, for hematodiarrhoea, have blood in stool, the diseases such as jaundice urine retention, eczema.Modern study shows; matrine in Radix Sophorae Flavescentis can significantly suppress kidney TGF-β 1 to express; improve the loose symptom of glomerule; alleviate albuminuria; to diabetes mellitus with kidney injury, there is protective effect; matrine also by regulating the activity of t-PA/PAI-1 to improve blood viscosity, reducing the discharge of early diabetic nephropathy urine protein, shielding to kidney.
Radix Ophiopogonis: cold nature, sweet in the mouth, micro-hardship; GUIXIN, lung, stomach warp; The effect such as have YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, quenches one's thirst for dryness of the lung dry cough, chronic consumptive disease cough, thirsty, the vexed insomnia of Tianjin wound, interior-heat, the disease such as dryness of the intestine constipation.Modern study shows, the Radix Ophiopogonis polysaccharide in Radix Ophiopogonis has the effect reducing blood glucose and stabilizing blood sugar, and surrounding tissue can be made to reduce insulin resistant.
Semen Lablab Album: slightly warm in nature, sweet in the mouth; Return spleen, stomach warp; Have invigorating the spleen for eliminating dampness and in the effect such as to relieve summer heat, for diseases such as weakness of the spleen and stomach, inappetence, diarrhea, heat-damp in summer vomiting and diarrhoea, abdominal distention uncomfortable in chest.Modern study shows, long-term edible Semen Lablab Album is conducive to insulin normal secretions, has significant preventive and therapeutic effect to type Ⅱdiabetes mellitus complicated hypertension disease.
Radix Ginseng: property is put down, sweet in the mouth, micro-hardship; Return spleen, lung, heart channel; Have that strongly invigorating primordial QI, multiple arteries and veins are admittedly de-, invigorating the spleen to benefit the lung, promote the production of body fluid, the effect such as to calm the nerves, for the disease such as weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, Tianjin wound is thirsty, interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia.Modern study shows, Radix Ginseng and effective ingredient ginsenoside thereof have the effect reducing blood glucose, improve diabetic symptom, wherein ginsenoside Re can strengthen the function of insulin, plays the effect of " para-insulin ", and ginsenoside Rb1 has the effect of similar euglycemic agent sample.
Radix Glycyrrhizae: property is put down, taste is put down; GUIXIN, lung, spleen, stomach warp; There are the effects such as invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for diseases such as weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, and can cushion toxicity, strong.Modern study shows, Radix Glycyrrhizae contains the material that some have anti-diabetic effect, and these materials not only can reduce blood glucose, can also antiinflammatory, and toleration is fabulous.
Herba Dendrobii: cold nature, sweet in the mouth; Return stomach, lung, kidney channel; There is the effect such as the stomach reinforcing that promotes the production of body fluid, nourishing YIN and clearing away heat, lung moistening kidney tonifying, the strong waist of improving eyesight, do not move back for consumption of body fluid caused by febrile disease, xerostomia excessive thirst, deficiency of stomach-Yin, stomachache retch, dryness of the lung dry cough, deficiency-heat, the moon hinders the diseases such as order is dark, waist knee joint is weak.Modern study shows, Herba Dendrobii by regulating the hormonal readiness performance hypoglycemic activity of pancreatic islet alpha, β emiocytosis, and has in pancreas and the outer hypoglycemic mechanism of action of pancreas.
Remarkable advantage of the present invention is:
(1) the present invention uses tradition and modern Chinese medicine theory, according to Fructus Momordicae charantiae, Radix Momordicae Charantiae, Ganoderma spore powder, the result of study of the modern pharmacology such as Cordyceps militaris (L.) Link. and Herba Dendrobii pharmacodynamics, with pure natural medical compatibility, scientific composition, advanced technologies, the compound antihypelipidemic pill developed not only has significant reduction blood glucose function, the polydipsia that obvious alleviation causes because of diabetes, polyuria, polyphagia, become thin and the symptom such as fatigue and weak, and there is strengthening the body resistance, benefiting QI and nourishing blood and immunoregulatory health care prophylactic function, carry in addition simultaneously and store feature easily, be applicable to diabetics long-term taking.
(2) show that the hypoglycemic effect of Radix Momordicae Charantiae is also better than Fructus Momordicae charantiae according to current research, but yet there are no Radix Momordicae Charantiae is used for the treatment of diabetes; Radix Momordicae Charantiae is the garbage in Fructus Momordicae charantiae production process simultaneously, Radix Momordicae Charantiae is carried out compatibility and is used for the treatment of diabetes, not only creative, also has the economic worth of twice laid simultaneously.
(3) current, medicine pill is mainly taked starch to carry out rubbing to become ball, and starch a kind of food material that to be diabetics will strictly control takes in. the present invention adopts Radix Et Rhizoma Fagopyri Tatarici powder to replace starch to carry out rubbing to become ball, not only can successfully prepare good pellet product, also can play the hypoglycemic activity of Radix Et Rhizoma Fagopyri Tatarici simultaneously, therefore there is obvious creative effect.
Detailed description of the invention
embodiment 1
A kind of compound antihypelipidemic pill, the percentage by weight of its raw material composition and each raw material is: Fructus Momordicae charantiae 30%, Radix Momordicae Charantiae 5%, Radix Et Rhizoma Fagopyri Tatarici 11%, Cordyceps militaris (L.) Link. 5%, Ganoderma spore powder 6%, the Radix Astragali 20%, Radix Trichosanthis 1%, the Rhizoma Anemarrhenae 2%, Semen Cassiae 1%, Fructus Lycii 3%, Radix Sophorae Flavescentis 2%, Radix Ophiopogonis 1%, Semen Lablab Album 2%, Radix Ginseng 5%, Radix Glycyrrhizae 1%, Herba Dendrobii 5%.
Its preparation method concrete steps are as follows:
1), pulverize: Ganoderma spore powder is carried out wall breaking pulverization, obtains Ganoderma spore powder with cellular wall broken for subsequent use; Cordyceps militaris (L.) Link., Semen Cassiae and Herba Dendrobii are carried out micronizing respectively, obtains Cordyceps militaris (L.) Link. powder, Semen Cassiae powder and dendrobium officinale powder for subsequent use; Radix Et Rhizoma Fagopyri Tatarici being fried to tendering with a crispy crust, pulverizing 100 mesh sieves, and obtaining Radix Et Rhizoma Fagopyri Tatarici powder for subsequent use;
2), lixiviate: it is 90% alcoholic solution that Fructus Momordicae charantiae and Radix Momordicae Charantiae are added mass fraction by mass volume ratio 1:4, reflux, extract, 0.5 hour, collects ethanol extract a, and then add water by mass volume ratio 1:4, hot water return lixiviate 2 times, Extracting temperature 100 DEG C, each 0.5 hour, collect extracting solution b; Decoct with water 2 times by mass volume ratio 1:4, each 0.5 hour by after the Radix Astragali, Radix Trichosanthis, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Sophorae Flavescentis, Radix Ophiopogonis, Semen Lablab Album, Radix Ginseng and Radix Glycyrrhizae mixing, decoct temperature 100 DEG C, collect extracting solution c;
3), concentrated: extracting solution a, b and c are mixed, adopt 60000Da ultrafilter membrane 40 DEG C, filter under 0.30MPa pressure, concentrated, obtain the concentrated solution that relative density is 1.05;
4), mix: the Radix Et Rhizoma Fagopyri Tatarici powder added respectively in concentrated solution, Ganoderma spore powder with cellular wall broken, Cordyceps militaris (L.) Link. powder, Semen Cassiae powder and dendrobium officinale powder, mix homogeneously also rubs into dough sample soft material;
5), rubbing becomes ball: dough sample soft material is placed 20 minutes, after spice to mix with Radix Et Rhizoma Fagopyri Tatarici powder and produces viscosity, rubs that thickness is consistent, the strip of smooth in appearance with hand pellet processing machine, then makes smooth, the spherical pill in garden with pellet processing machine, every heavy 0.3g of ball;
6), airing: ready-made pill is placed on after drying in low temp. sterilizing case and packs again.
embodiment 2
A kind of compound antihypelipidemic pill, the percentage by weight of its raw material composition and each raw material is: Fructus Momordicae charantiae 12%, Radix Momordicae Charantiae 6%, Radix Et Rhizoma Fagopyri Tatarici 10%, Cordyceps militaris (L.) Link. 20%, Ganoderma spore powder 20%, the Radix Astragali 5%, Radix Trichosanthis 2%, the Rhizoma Anemarrhenae 5%, Semen Cassiae 2%, Fructus Lycii 2%, Radix Sophorae Flavescentis 5%, Radix Ophiopogonis 2%, Semen Lablab Album 5%, Radix Ginseng 2%, Radix Glycyrrhizae 1%, Herba Dendrobii 1%.
Its preparation method concrete steps are as follows:
1), pulverize: Ganoderma spore powder is carried out wall breaking pulverization, obtains Ganoderma spore powder with cellular wall broken for subsequent use; Cordyceps militaris (L.) Link., Semen Cassiae and Herba Dendrobii are carried out micronizing respectively, obtains Cordyceps militaris (L.) Link. powder, Semen Cassiae powder and dendrobium officinale powder for subsequent use; Radix Et Rhizoma Fagopyri Tatarici being fried to tendering with a crispy crust, pulverizing 100 mesh sieves, and obtaining Radix Et Rhizoma Fagopyri Tatarici powder for subsequent use;
2), lixiviate: it is 80% alcoholic solution that Fructus Momordicae charantiae and Radix Momordicae Charantiae are added mass fraction by mass volume ratio 1:5, reflux, extract, 1.0 hours, collects ethanol extract a, and then add water by mass volume ratio 1:6, hot water return lixiviate 2 times, Extracting temperature 100 DEG C, each 1.2 hours, collect extracting solution b; Decoct with water 2 times by mass volume ratio 1:5, each 1.0 hours by after the Radix Astragali, Radix Trichosanthis, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Sophorae Flavescentis, Radix Ophiopogonis, Semen Lablab Album, Radix Ginseng and Radix Glycyrrhizae mixing, decoct temperature 100 DEG C, collect extracting solution c;
3), concentrated: extracting solution a, b and c are mixed, adopt 60000Da ultrafilter membrane 80 DEG C, filter under 0.40MPa pressure, concentrated, obtain the concentrated solution that relative density is 1.00;
4), mix: the Radix Et Rhizoma Fagopyri Tatarici powder added respectively in concentrated solution, Ganoderma spore powder with cellular wall broken, Cordyceps militaris (L.) Link. powder, Semen Cassiae powder and dendrobium officinale powder, mix homogeneously also rubs into dough sample soft material;
5), rubbing becomes ball: dough sample soft material is placed 25 minutes, after spice to mix with Radix Et Rhizoma Fagopyri Tatarici powder and produces viscosity, rubs that thickness is consistent, the strip of smooth in appearance with hand pellet processing machine, then makes smooth, the spherical pill in garden with pellet processing machine, every heavy 0.2g of ball;
6), airing: ready-made pill is placed on after drying in low temp. sterilizing case and packs again.
embodiment 3
A kind of compound antihypelipidemic pill, the percentage by weight of its raw material composition and each raw material is: Fructus Momordicae charantiae 10%, Radix Momordicae Charantiae 20%, Radix Et Rhizoma Fagopyri Tatarici 30%, Cordyceps militaris (L.) Link. 6%, Ganoderma spore powder 5%, the Radix Astragali 7%, Radix Trichosanthis 5%, the Rhizoma Anemarrhenae 1%, Semen Cassiae 5%, Fructus Lycii 1%, Radix Sophorae Flavescentis 1%, Radix Ophiopogonis 3%, Semen Lablab Album 1%, Radix Ginseng 1%, Radix Glycyrrhizae 3%, Herba Dendrobii 1%.
Its preparation method concrete steps are as follows:
1), pulverize: Ganoderma spore powder is carried out wall breaking pulverization, obtains Ganoderma spore powder with cellular wall broken for subsequent use; Cordyceps militaris (L.) Link., Semen Cassiae and Herba Dendrobii are carried out micronizing respectively, obtains Cordyceps militaris (L.) Link. powder, Semen Cassiae powder and dendrobium officinale powder for subsequent use; Radix Et Rhizoma Fagopyri Tatarici being fried to tendering with a crispy crust, pulverizing 100 mesh sieves, and obtaining Radix Et Rhizoma Fagopyri Tatarici powder for subsequent use;
2), lixiviate: it is 60% alcoholic solution that Fructus Momordicae charantiae and Radix Momordicae Charantiae are added mass fraction by mass volume ratio 1:8, reflux, extract, 1.5 hours, collects ethanol extract a, and then add water by mass volume ratio 1:8, hot water return lixiviate 2 times, Extracting temperature 100 DEG C, each 1.5 hours, collect extracting solution b; Decoct with water 2 times by mass volume ratio 1:8, each 1.5 hours by after the Radix Astragali, Radix Trichosanthis, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Sophorae Flavescentis, Radix Ophiopogonis, Semen Lablab Album, Radix Ginseng and Radix Glycyrrhizae mixing, decoct temperature 100 DEG C, collect extracting solution c;
3), concentrated: extracting solution a, b and c are mixed, adopt 60000Da ultrafilter membrane 60 DEG C, filter under 0.40MPa pressure, concentrated, obtain the concentrated solution that relative density is 1.10;
4), mix: the Radix Et Rhizoma Fagopyri Tatarici powder added respectively in concentrated solution, Ganoderma spore powder with cellular wall broken, Cordyceps militaris (L.) Link. powder, Semen Cassiae powder and dendrobium officinale powder, mix homogeneously also rubs into dough sample soft material;
5), rubbing becomes ball: dough sample soft material is placed 30 minutes, after spice to mix with Radix Et Rhizoma Fagopyri Tatarici powder and produces viscosity, rubs that thickness is consistent, the strip of smooth in appearance with hand pellet processing machine, then makes smooth, the spherical pill in garden with pellet processing machine, every heavy 0.1g of ball;
6), airing: ready-made pill is placed on after the dry place of room ventilation dries and packs again.
The present invention is according to the result of study of modern pharmacology pharmacodynamics, compatibility is carried out with pure natural medicals such as Fructus Momordicae charantiae, Radix Momordicae Charantiae, Ganoderma spore powder, Cordyceps militaris (L.) Link. and Herba Dendrobii, after obtained compound antihypelipidemic pill takes 5-10 days, blood glucose is steady, the symptoms such as patient's polydipsia, polyphagia, polyuria are alleviated to some extent, and feeling of fatigue alleviates; After taking 30 days, blood glucose target obviously reduces, and thirsty, the symptom such as hyperhidrosis, frequent urination at night is significantly improved, and patient's energy obviously promotes; After taking 2-3 month, the every physiological function of patient is restored, and takes maintenance dose and preserves diet and exercise therapy, can maintain blood glucose level normal steady.Therefore, compound antihypelipidemic pill of the present invention has significant reduction blood glucose function, obviously can alleviate the polydipsia because diabetes cause, polyuria, polyphagia, become thin and the symptom such as fatigue and weak, and there is strengthening the body resistance, benefiting QI and nourishing blood and immunoregulatory health care prophylactic function, be applicable to diabetics long-term taking.
Model case
Example 1: patient, female, 66 years old, suffers from more than 20 years of diabetes.Often blood glucose can be controlled with the medicine such as glyburide, metformin.Glycemic control is undesirable in recent years, and use the medicines such as hydrochloric acid pioglitazone, acarbose instead, blood glucose is also everlasting between 9 ~ 11mmol/L and is fluctuated, and with symptoms such as polydipsia, polyuria, polyphagia and fatigue and weaks, requirement injection of insulin is treated.For reducing the inconvenience that injectable drug brings, being aided with this compound antihypelipidemic pill and carrying out auxiliary treatment.After serveing on 10 days, the symptoms such as polydipsia, polyphagia, polyuria are alleviated to some extent, and feeling of fatigue alleviates, and check glucostasis is at 6.5-7.5mmol/L.While adhering to taking this compound antihypelipidemic pill, change injection of insulin for taking the blood sugar lowering western medicines such as hydrochloric acid pioglitazone, acarbose, after taking 20 days continuously, the symptoms such as polydipsia, polyphagia, polyuria obviously disappear, and repeatedly check glucostasis at 6.0-7.0mmol/L.Start February, the blood sugar lowering Western medicine such as hydrochloric acid pioglitazone, acarbose are withdrawn in trial, only take this compound antihypelipidemic pill, and take diet and exercise therapy, check the ideal range of glycemic control at about 6mmol/L after 1 month, simultaneously the symptom such as polydipsia, polyphagia, polyuria disappears completely.
Example 2: patient, man, 47 years old, because of thirsty polydipsia, weight loss (10kg) in two weeks, to examination in hospital, blood glucose 9.0mmol/L, does not take antidiabetic drug, within 3rd, check blood glucose 8.5mmol/L afterwards, glucose in urine (++), its trouble type 2 diabetes mellitus of hospital diagnosis.Patient is reluctant to take Western medicine antidiabetic drug, this compound antihypelipidemic pill is taken in selection, after serveing on 5 days, check blood glucose 5.5mmol/L, thirsty polydipsia symptom is obviously alleviated, for consolidate curative effect continues to take for 4 week, and check blood glucose per week 1 time, all belong in normal range, the ill front level (70kg) of weight recovery after 1 month.
The foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Claims (2)
1. a compound antihypelipidemic pill, is characterized in that: its raw material consists of: Fructus Momordicae charantiae, Radix Momordicae Charantiae, Radix Et Rhizoma Fagopyri Tatarici, Cordyceps militaris (L.) Link., Ganoderma spore powder, the Radix Astragali, Radix Trichosanthis, the Rhizoma Anemarrhenae, Semen Cassiae, Fructus Lycii, Radix Sophorae Flavescentis, Radix Ophiopogonis, Semen Lablab Album, Radix Ginseng, Radix Glycyrrhizae and Herba Dendrobii;
The percentage by weight of each raw material is: Fructus Momordicae charantiae 10-30%, Radix Momordicae Charantiae 5-20%, Radix Et Rhizoma Fagopyri Tatarici 10-30%, Cordyceps militaris (L.) Link. 5-20%, Ganoderma spore powder 5-20%, Radix Astragali 5-20%, Radix Trichosanthis 1-5%, Rhizoma Anemarrhenae 1-5%, Semen Cassiae 1-5%, Fructus Lycii 1-3%, Radix Sophorae Flavescentis 1-5%, Radix Ophiopogonis 1-3%, Semen Lablab Album 1-5%, Radix Ginseng 1-5%, Radix Glycyrrhizae 1-3%, Herba Dendrobii 1-5%, the percentage by weight sum of above-mentioned each raw material is 100%.
2. prepare a method for compound antihypelipidemic pill as claimed in claim 1, it is characterized in that: the concrete steps of described method are as follows:
1), pulverize: Ganoderma spore powder is carried out wall breaking pulverization, obtains Ganoderma spore powder with cellular wall broken for subsequent use; Cordyceps militaris (L.) Link., Semen Cassiae and Herba Dendrobii are carried out micronizing respectively, obtains Cordyceps militaris (L.) Link. powder, Semen Cassiae powder and dendrobium officinale powder for subsequent use; Radix Et Rhizoma Fagopyri Tatarici being fried to tendering with a crispy crust, pulverizing 100 mesh sieves, and obtaining Radix Et Rhizoma Fagopyri Tatarici powder for subsequent use;
2), lixiviate: it is 60%-90% alcoholic solution that Fructus Momordicae charantiae and Radix Momordicae Charantiae are added mass fraction by mass volume ratio 1:4 ~ 8, reflux, extract, 0.5-1.5 hour, collect ethanol extract a, and then add water by mass volume ratio 1:4 ~ 8, hot water return lixiviate 2 times, Extracting temperature 100 DEG C, each 0.5-1.5 hour, collects extracting solution b; Decoct with water 2 times by mass volume ratio 1:4 ~ 8, each 0.5-1.5 hour by after the Radix Astragali, Radix Trichosanthis, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Sophorae Flavescentis, Radix Ophiopogonis, Semen Lablab Album, Radix Ginseng and Radix Glycyrrhizae mixing, decoct temperature 100 DEG C, collect extracting solution c;
3), concentrated: extracting solution a, b and c are mixed, adopt 60000Da ultrafilter membrane 40-60 DEG C, filter under 0.30-0.40MPa pressure, concentrated, obtain the concentrated solution that relative density is 1.05-1.10;
4), mix: the Radix Et Rhizoma Fagopyri Tatarici powder added respectively in concentrated solution, Ganoderma spore powder with cellular wall broken, Cordyceps militaris (L.) Link. powder, Semen Cassiae powder and dendrobium officinale powder, mix homogeneously also rubs into dough sample soft material;
5), rubbing becomes ball: dough sample soft material is placed 20-30 minute, after spice to mix with Radix Et Rhizoma Fagopyri Tatarici powder and produces viscosity, rub with hand pellet processing machine that thickness is consistent, the strip of smooth in appearance, then make smooth, spheroidal pill with pellet processing machine, every heavy 0.1-0.3g of ball;
6), dry: ready-made pill is placed on after drying in the dry place of room ventilation or low temp. sterilizing case and packs again.
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