CN103656753B - Neutral calcium phosphate bone cement and preparation method thereof - Google Patents
Neutral calcium phosphate bone cement and preparation method thereof Download PDFInfo
- Publication number
- CN103656753B CN103656753B CN201310642406.5A CN201310642406A CN103656753B CN 103656753 B CN103656753 B CN 103656753B CN 201310642406 A CN201310642406 A CN 201310642406A CN 103656753 B CN103656753 B CN 103656753B
- Authority
- CN
- China
- Prior art keywords
- bone cement
- cement powder
- preparation
- neutral
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002639 bone cement Substances 0.000 title claims abstract description 74
- 230000007935 neutral effect Effects 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000001506 calcium phosphate Substances 0.000 title claims abstract description 13
- 229910000389 calcium phosphate Inorganic materials 0.000 title claims abstract description 13
- 235000011010 calcium phosphates Nutrition 0.000 title claims abstract description 13
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 40
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 238000007711 solidification Methods 0.000 claims abstract description 9
- 230000008023 solidification Effects 0.000 claims abstract description 9
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 8
- 239000007787 solid Substances 0.000 claims abstract description 8
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 15
- 238000007596 consolidation process Methods 0.000 claims description 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- -1 hydroxypropyl Chemical group 0.000 claims description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 239000004115 Sodium Silicate Substances 0.000 claims description 3
- 238000000498 ball milling Methods 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 229920000858 Cyclodextrin Polymers 0.000 claims description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 239000004111 Potassium silicate Substances 0.000 claims description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 2
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 2
- 229910052786 argon Inorganic materials 0.000 claims description 2
- 238000001354 calcination Methods 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- 235000012241 calcium silicate Nutrition 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 239000011261 inert gas Substances 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 239000001103 potassium chloride Substances 0.000 claims description 2
- 235000011164 potassium chloride Nutrition 0.000 claims description 2
- NNHHDJVEYQHLHG-UHFFFAOYSA-N potassium silicate Chemical compound [K+].[K+].[O-][Si]([O-])=O NNHHDJVEYQHLHG-UHFFFAOYSA-N 0.000 claims description 2
- 235000019353 potassium silicate Nutrition 0.000 claims description 2
- 229910052913 potassium silicate Inorganic materials 0.000 claims description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 2
- 235000011151 potassium sulphates Nutrition 0.000 claims description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 229960002901 sodium glycerophosphate Drugs 0.000 claims description 2
- 235000019794 sodium silicate Nutrition 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- REULQIKBNNDNDX-UHFFFAOYSA-M sodium;2,3-dihydroxypropyl hydrogen phosphate Chemical compound [Na+].OCC(O)COP(O)([O-])=O REULQIKBNNDNDX-UHFFFAOYSA-M 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 230000002378 acidificating effect Effects 0.000 abstract 2
- 238000002156 mixing Methods 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000004570 mortar (masonry) Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940078495 calcium phosphate dibasic Drugs 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 238000003746 solid phase reaction Methods 0.000 description 1
- 238000010671 solid-state reaction Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a method belonging to the technical field of biomedical materials, and concretely relates to a neutral calcium phosphate bone cement and a preparation method thereof. The preparation method is characterized in that the preparation method comprises the following steps: preparing a bone cement powder main component by appropriately controlling reaction conditions; adding a certain amount of hydroxyapatite and silicate to the above powder, and fully and uniformly mixing to prepare bone cement powder; and blending the bone cement powder with a citric acid-containing solidification liquid according to a certain liquid/solid ratio to obtain neutral bone cement, and putting solidified bone cement in water to obtain a neutral solution. The preparation method of the neutral bone cement enriches the range of the bone cement powder, allows acidic solidification liquids to be widely applied in injectable bone cements, and has the advantages of simplicity, feasibility, good effect, suitableness for the popularization in different acidic solidification liquids, and large scale application.
Description
Technical field
The present invention relates to a kind of method of biology medical material technical field, specifically a kind of neutral calcium phosphate pastern bone cement and preparation method thereof.
Background technology
In some calcium phosphate bone cement systems, in order to promote bone cement powder curing molding better and keep high compressive strength, general needs add a large amount of citric acids ［ M. Anirban Jyoti, Applied Surface Science, 2010 ］ in bone cement consolidation liquid.Blemish in an otherwise perfect thing, citric acid is effectively promoting bone cement curing molding and while keeping advantages of higher compressive strength, is also often causing bone cement to be highly acid.The existence of a large amount of proton generally can cause cell death, seriously limits its application in vivo.
The present invention is directed to above background with not enough, bone cement of a kind of novelty and preparation method thereof is provided, by regulating and controlling preparation technology and the composition of bone cement, while raising bone cement mechanical strength, the highly acid problem that can effectively avoid traditional method to bring.
Summary of the invention
Neutral bone cement that the object of the present invention is to provide a kind of novelty and preparation method thereof, be grouped into by the preparation technology and one-tenth thereof that regulate and control bone cement, while raising bone cement mechanical strength, the highly acid problem of the bone cement that can effectively avoid traditional method to bring.
Object of the present invention is achieved through the following technical solutions: fully mixed with calcium carbonate powder by a certain proportion of calcium hydrogen phosphate; Then adopting the method for solid state reaction, preparing bone cement powder bulk composition by controlling reaction condition rightly.A certain amount of hydroxyapatite is added on this basis and the abundant mix homogeneously of silicate prepares bone cement powder in powder.Bone cement powder is in harmonious proportion by certain liquid-solid ratio with containing the consolidation liquid of citric acid, hardening time can be obtained without significant prolongation or the neutral bone cement that shortens to some extent.
A preparation method for neutral calcium phosphate bone cement, is characterized in that, comprises the following steps:
(1) bone cement powder bulk composition is obtained after calcination in 900 DEG C of stoves after being mixed by raw material, ball milling;
(2) in bone cement powder bulk composition, hydroxyapatite is added and silicate prepares bone cement powder;
(3) if bone cement powder for a long time need not, be stored in 4 DEG C of dry enclosed environments;
(4) bone cement powder and acid consolidation liquid are in harmonious proportion by liquid-solid ratio, can neutral calcium phosphate bone cement be obtained.
Calcium hydrogen phosphate and the calcium carbonate mixture of to be mol ratio be 2:0.90 to the 2:1.15 of the raw material described in step (1).
Hydroxyapatite described in step (2) is of a size of and is less than 5 mm, and its content in bone cement powder is 0.05-60%.
Silicate described in step (2) is one in sodium silicate, potassium silicate, calcium silicates or its combination, and its content in bone cement is 0-30%.
Dry enclosed environment described in step (3) is that outside air can not directly contact with bone cement powder.
Dry enclosed environment described in step (3) for bone cement powder is placed in the inert gas environment such as nitrogen, argon, or is placed on after evacuation in exsiccator, electronic dry cabinet.
Acid consolidation liquid described in step (4) is the solution of citric acid content at 3-55%, or based on it, add 0.01-5% hydroxypropyl emthylcellulose, the sodium carboxymethyl cellulose of 0.01-2%, 0.01-4% chitosan, 0.01-2% gelatin, 0.01-1.5% polyvinyl alcohol, 0.01-10% Polyethylene Glycol, 0.01-2% sodium alginate, 0.01-5% starch, 0.01-1% hyaluronic acid, 0.01-2% collagen protein, 0.5-40% glycerol, 0.01-15% sodium sulfate, 0.01-15% potassium sulfate, 0.01-15% ammonium sulfate, 0.01-10% magnesium sulfate, 0.01-10% sodium chloride, 0.01-10% potassium chloride, 0.01-15% calcium chloride, 0.01-15% sodium glycerophosphate, 0.01-15% glucose, 0.01-15% mannose, 0.01-5% cyclodextrin one wherein or its combination.
Liquid-solid ratio described in step (4) is add 0.30-0.70 milliliter consolidation liquid in every 1 gram of bone cement powder.
The neutral calcium phosphate bone cement that method prepares according to above-mentioned any one, its pH value is 5-9, and after solidification, apparent density is not less than 1.30 g/cm
3, defeated and dispersed coefficient is not more than 5%.
The present invention is grouped into by the preparation technology and one-tenth thereof regulating and controlling bone cement and prepares a kind of Bone Colonizable Cements In Rabbits powder.Gained bone cement powder can effectively with citric acid system consolidation liquid curing molding, keep higher mechanical strength simultaneously.Preparation method provided by the invention is simple, easy, effective, be suitable for promoting the use of in the consolidation liquid system of difference containing citric acid, can large-scale application.
Apparent density method of testing is: first adopt the cylindrical mold of diameter 6 mm height 10 mm to prepare bone cement sample, then measure the actual diameter of the bone cement sample of solidification after 24 hours, height and quality, calculate its density and be apparent density.
The method of testing of defeated and dispersed coefficient is: after solidifying, bone cement to soak after 10 days Mass lost percentage ratio as defeated and dispersed coefficient in water.
PH value method of testing containing bone cement aqueous solution is: the bone cement after 1.0 g are solidified 24 hours is placed in 20 mL ultra-pure waters, then measures its pH value in different soak time with pH meter.
Accompanying drawing explanation
After Figure 1 shows that solidification, bone cement is placed on solution ph change curve in time after in water.
Detailed description of the invention
Following examples are implemented premised on invention technical scheme, give detailed embodiment and concrete operating process, but protection scope of the present invention are not limited to following embodiment.
Embodiment 1:
Take 86 g calcium phosphate dibasic dihydrates and 25 g calcium carbonate, joined ball milling mix homogeneously in 165 mL water.Then by water distilling under reduced pressure, in 80 DEG C of vacuum drying ovens, drying obtains mixed powder.After 900 DEG C of stove stage casings burn 15 hours, wet ball grinding is adopted to obtain bone cement dispersion liquid powder body.Obtain bone cement powder bulk composition after dispersion liquid is centrifugal, drying, powder body is of a size of 300-800 nm.
Embodiment 2:
96 g bone cement powder bulk composition and 4 g hydroxyapatite mortar grinder are evenly obtained bone cement powder.The consolidation liquid of 20% citric acid-1% hydroxypropyl emthylcellulose composition and bone cement powder are in harmonious proportion by the liquid-solid ratio of 0.5 mL/g, it is 11 min that reference standard ASTM C191 measures the presetting period.After solidification, bone cement apparent density is 1.45 g/cm
3, defeated and dispersed coefficient is 1.5%.Be added to the water, solution is in neutral.After leaving standstill one week, test solution pH is substantially constant, and as shown in Figure 1, aqueous solution pH keeps neutral at long period yardstick always.
Embodiment 3:
91 g bone cement powder bulk composition and 4 g hydroxyapatite and 5 g sodium silicate mortar grinder are evenly obtained bone cement powder.The consolidation liquid of 20% citric acid-1% hydroxypropyl emthylcellulose composition and bone cement powder are in harmonious proportion by the liquid-solid ratio of 0.5 mL/g, it is 9 min that reference standard ASTM C191 measures the presetting period.After solidification, bone cement apparent density is 1.48 g/cm
3, defeated and dispersed coefficient 2.2%.Be added to the water, solution is in neutral.After leaving standstill one week, pH value of solution is substantially constant, similar shown in result and Fig. 1.
Claims (4)
1. a preparation method for neutral calcium phosphate bone cement, is characterized in that, comprises the following steps:
(1) bone cement powder bulk composition is obtained after calcination in 900 DEG C of stoves after being mixed by raw material, ball milling;
Calcium hydrogen phosphate and the calcium carbonate mixture of described raw material to be mol ratio be 2:0.90 to 2:1.15;
(2) in bone cement powder bulk composition, hydroxyapatite is added and silicate prepares bone cement powder;
Described hydroxyapatite is of a size of and is less than 5 mm, and its content in bone cement powder is 0.05-60%;
Described silicate is one in sodium silicate, potassium silicate, calcium silicates or its combination, and its content in bone cement is 0-30%;
(3) if bone cement powder for a long time need not, be stored in 4 DEG C of dry enclosed environments;
(4) bone cement powder and acid consolidation liquid are in harmonious proportion by liquid-solid ratio, can neutral calcium phosphate bone cement be obtained;
Described acid consolidation liquid is the solution of citric acid content at 3-55%, or based on it, add 0.01-5% hydroxypropyl emthylcellulose, the sodium carboxymethyl cellulose of 0.01-2%, 0.01-4% chitosan, 0.01-2% gelatin, 0.01-1.5% polyvinyl alcohol, 0.01-10% Polyethylene Glycol, 0.01-2% sodium alginate, 0.01-5% starch, 0.01-1% hyaluronic acid, 0.01-2% collagen protein, 0.5-40% glycerol, 0.01-15% sodium sulfate, 0.01-15% potassium sulfate, 0.01-15% ammonium sulfate, 0.01-10% magnesium sulfate, 0.01-10% sodium chloride, 0.01-10% potassium chloride, 0.01-15% calcium chloride, 0.01-15% sodium glycerophosphate, 0.01-15% glucose, 0.01-15% mannose, 0.01-5% cyclodextrin one wherein or its combination, described liquid-solid ratio is add 0.30-0.70 milliliter consolidation liquid in every 1 gram of bone cement powder.
2. the preparation method of neutral calcium phosphate bone cement according to claim 1, it is characterized in that, the dry enclosed environment described in step (3) is that outside air can not directly contact with bone cement powder.
3. the preparation method of neutral calcium phosphate bone cement according to claim 2, it is characterized in that, dry enclosed environment described in step (3) for bone cement powder is placed in nitrogen, argon inert gas environment, or is placed on after evacuation in exsiccator, electronic dry cabinet.
4. the neutral calcium phosphate bone cement that method prepares according to claim 1-3 any one, its pH value is 5-9, and after solidification, apparent density is not less than 1.30 g/cm
3, defeated and dispersed coefficient is not more than 5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310642406.5A CN103656753B (en) | 2013-12-04 | 2013-12-04 | Neutral calcium phosphate bone cement and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310642406.5A CN103656753B (en) | 2013-12-04 | 2013-12-04 | Neutral calcium phosphate bone cement and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103656753A CN103656753A (en) | 2014-03-26 |
| CN103656753B true CN103656753B (en) | 2015-04-22 |
Family
ID=50296306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310642406.5A Expired - Fee Related CN103656753B (en) | 2013-12-04 | 2013-12-04 | Neutral calcium phosphate bone cement and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103656753B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524627B (en) * | 2014-12-23 | 2016-08-17 | 南京航空航天大学 | The preparation method of the hydroxyapatite bone cement of high intensity |
| CN106267365A (en) * | 2016-08-17 | 2017-01-04 | 林春梅 | A kind of enhancing activity injecting bone cement and preparation method thereof |
| CN106729971B (en) * | 2016-11-23 | 2019-12-27 | 上海纳米技术及应用国家工程研究中心有限公司 | Water-soluble single-walled carbon nanotube modified calcium phosphate cement and preparation and application thereof |
| CN106540317A (en) * | 2016-12-08 | 2017-03-29 | 苏州艾博迈尔新材料有限公司 | A kind of realizing controlled-release bone cement and preparation method thereof |
| CN106620886A (en) * | 2016-12-09 | 2017-05-10 | 苏州纳贝通环境科技有限公司 | Liquid bracket material for bone repair and preparation method thereof |
| CN108273131B (en) * | 2018-03-19 | 2021-07-27 | 深圳市中科海世御生物科技有限公司 | Composite bone cement, preparation method and application thereof, and bone repair material |
| CN109498846B (en) * | 2018-10-09 | 2021-07-16 | 广州润虹医药科技股份有限公司 | Bone repair scaffold capable of releasing zinc ions and strontium ions simultaneously and preparation method thereof |
| CN110201228A (en) * | 2019-04-19 | 2019-09-06 | 湖北联结生物材料有限公司 | A kind of calcium phosphate bone cement and its preparation method and application containing decalcified bone matrix |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149368A (en) * | 1991-01-10 | 1992-09-22 | Liu Sung Tsuen | Resorbable bioactive calcium phosphate cement |
| US6214048B1 (en) * | 1992-02-10 | 2001-04-10 | Matsumoto Dental College | Bone substitute product and method of producing the same |
| CN1826145A (en) * | 2003-05-23 | 2006-08-30 | 奥图斯医疗有限公司 | Improved calcium phosphate bone cements |
| CN102989042A (en) * | 2012-12-21 | 2013-03-27 | 上海纳米技术及应用国家工程研究中心有限公司 | Injectable porous bone cement and preparation method thereof |
| CN102989037A (en) * | 2012-12-21 | 2013-03-27 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of gelatin-enhanced bone cement |
| CN103007340A (en) * | 2013-01-15 | 2013-04-03 | 河南理工大学 | Self-setting composite bone repair material for human body hard tissue repair and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1396984B1 (en) * | 2009-12-17 | 2012-12-20 | Merello | A BONE CEMENT CALCIUMPHOSPHATE, PROCEDURE FOR ITS PREPARATION AND ITS USES |
-
2013
- 2013-12-04 CN CN201310642406.5A patent/CN103656753B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149368A (en) * | 1991-01-10 | 1992-09-22 | Liu Sung Tsuen | Resorbable bioactive calcium phosphate cement |
| US6214048B1 (en) * | 1992-02-10 | 2001-04-10 | Matsumoto Dental College | Bone substitute product and method of producing the same |
| CN1826145A (en) * | 2003-05-23 | 2006-08-30 | 奥图斯医疗有限公司 | Improved calcium phosphate bone cements |
| CN102989042A (en) * | 2012-12-21 | 2013-03-27 | 上海纳米技术及应用国家工程研究中心有限公司 | Injectable porous bone cement and preparation method thereof |
| CN102989037A (en) * | 2012-12-21 | 2013-03-27 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of gelatin-enhanced bone cement |
| CN103007340A (en) * | 2013-01-15 | 2013-04-03 | 河南理工大学 | Self-setting composite bone repair material for human body hard tissue repair and application |
Non-Patent Citations (2)
| Title |
|---|
| 增强型自固化磷酸钙骨水泥的制备与性能;顾涛;《中国优秀硕士学位论文全文数据库 医药卫生科技辑》;20111215(第12期);第7页第2段、第34页第3段 * |
| 磷酸钙骨水泥生物材料制备与性能研究;刘兵;《中国优秀硕士学位论文全文数据库 医药卫生科技辑》;20060515(第5期);全文 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103656753A (en) | 2014-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103656753B (en) | Neutral calcium phosphate bone cement and preparation method thereof | |
| Su et al. | Influence of bacterial self-healing agent on early age performance of cement-based materials | |
| JP6940090B2 (en) | Microorganism-encapsulated microcapsules, cement admixtures containing microbial-encapsulated microcapsules, and repair materials for cement-based structures | |
| CN103656744B (en) | Bone cement solidification liquid, and preparation method and application thereof | |
| CN103086738A (en) | Preparation method for gypsum mold raw materials and gypsum mold | |
| CN103332960A (en) | Method for controlling setting and hardening processes of magnesium phosphate cement | |
| CN110467385A (en) | Friendly composite gelled material of a kind of ecology using solid waste material and preparation method thereof | |
| CN111574166B (en) | Alkali-activated cementing material and preparation method thereof | |
| CN111606636A (en) | A kind of preparation method of early-strength glutinous rice mortar material | |
| CN112551957B (en) | Graphene oxide reinforced carbonization hardening composite material and preparation method thereof | |
| CN104496395A (en) | Magnesium phosphate cement as well as preparation method and application thereof | |
| CN102989037A (en) | Preparation method of gelatin-enhanced bone cement | |
| CN103964889A (en) | Aerated concrete prepared from coal ash-nanosilicon dioxide-silica fume as main siliceous material | |
| CN104402456A (en) | Self-foaming injection-molding gel-forming porous ceramic preparation method | |
| CN104803619A (en) | Geopolymer composition and geopolymer material | |
| CN101234862B (en) | Preparation method of nano-modifier for cement-based materials | |
| CN107265992A (en) | Slow-release anti-cracking repair material and preparation method thereof | |
| CN101966348A (en) | Strontium-doped hydroxyapatite and collagen composite material and application and preparation method thereof | |
| CN105130307A (en) | Method for preparing high-fluidity silica mortar | |
| CN102424540B (en) | Preparation method for magnesite material water resistance modifier, and use method thereof | |
| CN105414469A (en) | Easily-demolding composite modified sodium silicate sand used for pump valve casting and preparing method thereof | |
| JP6123123B2 (en) | Method for producing cement-based hydrated mixture, cement-based hydrated mixture, and cement-based cured product | |
| CN115286270A (en) | A kind of tannic acid modified magnesium oxychloride cement and preparation method thereof | |
| CN105079872B (en) | Artificial material for fine repair and preparation method thereof | |
| CN103690990A (en) | Collapse-resistance injection neutral bone cement and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150422 Termination date: 20171204 |