CN103656753A - Neutral calcium phosphate bone cement and preparation method thereof - Google Patents
Neutral calcium phosphate bone cement and preparation method thereof Download PDFInfo
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- CN103656753A CN103656753A CN201310642406.5A CN201310642406A CN103656753A CN 103656753 A CN103656753 A CN 103656753A CN 201310642406 A CN201310642406 A CN 201310642406A CN 103656753 A CN103656753 A CN 103656753A
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- 239000002639 bone cement Substances 0.000 title claims abstract description 79
- 230000007935 neutral effect Effects 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000001506 calcium phosphate Substances 0.000 title claims abstract description 18
- 229910000389 calcium phosphate Inorganic materials 0.000 title claims abstract description 18
- 235000011010 calcium phosphates Nutrition 0.000 title claims abstract description 18
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 18
- 239000000843 powder Substances 0.000 claims abstract description 40
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 8
- 239000007787 solid Substances 0.000 claims abstract description 8
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 13
- 238000007596 consolidation process Methods 0.000 claims description 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- -1 hydroxypropyl Chemical group 0.000 claims description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 239000004115 Sodium Silicate Substances 0.000 claims description 3
- 238000000498 ball milling Methods 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 229920000858 Cyclodextrin Polymers 0.000 claims description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 239000004111 Potassium silicate Substances 0.000 claims description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 2
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 2
- 229910052786 argon Inorganic materials 0.000 claims description 2
- 238000001354 calcination Methods 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- 235000012241 calcium silicate Nutrition 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 239000011261 inert gas Substances 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 239000001103 potassium chloride Substances 0.000 claims description 2
- 235000011164 potassium chloride Nutrition 0.000 claims description 2
- NNHHDJVEYQHLHG-UHFFFAOYSA-N potassium silicate Chemical compound [K+].[K+].[O-][Si]([O-])=O NNHHDJVEYQHLHG-UHFFFAOYSA-N 0.000 claims description 2
- 235000019353 potassium silicate Nutrition 0.000 claims description 2
- 229910052913 potassium silicate Inorganic materials 0.000 claims description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 2
- 235000011151 potassium sulphates Nutrition 0.000 claims description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 229960002901 sodium glycerophosphate Drugs 0.000 claims description 2
- 235000019794 sodium silicate Nutrition 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- REULQIKBNNDNDX-UHFFFAOYSA-M sodium;2,3-dihydroxypropyl hydrogen phosphate Chemical compound [Na+].OCC(O)COP(O)([O-])=O REULQIKBNNDNDX-UHFFFAOYSA-M 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 238000007711 solidification Methods 0.000 abstract 3
- 230000008023 solidification Effects 0.000 abstract 3
- 230000002378 acidificating effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 238000000465 moulding Methods 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000004570 mortar (masonry) Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940078495 calcium phosphate dibasic Drugs 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 238000003746 solid phase reaction Methods 0.000 description 1
- 238000010671 solid-state reaction Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
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Abstract
The invention relates to a method belonging to the technical field of biomedical materials, and concretely relates to a neutral calcium phosphate bone cement and a preparation method thereof. The preparation method is characterized in that the preparation method comprises the following steps: preparing a bone cement powder main component by appropriately controlling reaction conditions; adding a certain amount of hydroxyapatite and silicate to the above powder, and fully and uniformly mixing to prepare bone cement powder; and blending the bone cement powder with a citric acid-containing solidification liquid according to a certain liquid/solid ratio to obtain neutral bone cement, and putting solidified bone cement in water to obtain a neutral solution. The preparation method of the neutral bone cement enriches the range of the bone cement powder, allows acidic solidification liquids to be widely applied in injectable bone cements, and has the advantages of simplicity, feasibility, good effect, suitableness for the popularization in different acidic solidification liquids, and large scale application.
Description
Technical field
The present invention relates to a kind of method of bio-medical material technical field, specifically a kind of neutral calcium phosphate pastern bone cement and preparation method thereof.
Background technology
In some calcium phosphate bone cement systems, in order to promote better bone cement powder curing molding and to keep high compressive strength, generally need in bone cement consolidation liquid, add a large amount of citric acid ［ M. Anirban Jyoti, Applied Surface Science, 2010 ］.Blemish in an otherwise perfect thing, citric acid, when effectively promoting bone cement curing molding and keeping advantages of higher compressive strength, also often causes bone cement to be highly acid.The existence of a large amount of protons generally can cause cell death, has seriously limited its application in vivo.
The present invention is directed to above background with not enough, bone cement of a kind of novelty and preparation method thereof is provided, by preparation technology and the composition of regulation and control bone cement, when improving bone cement mechanical strength, the highly acid problem that can effectively avoid traditional method to bring.
Summary of the invention
The object of the present invention is to provide neutral bone cement of a kind of novelty and preparation method thereof, preparation technology and one-tenth thereof by regulation and control bone cement are grouped into, when improving bone cement mechanical strength, can effectively avoid the highly acid problem of the bone cement that traditional method brings.
Object of the present invention is achieved through the following technical solutions: a certain proportion of calcium hydrogen phosphate is fully mixed with calcium carbonate powder; Then adopt the method for solid state reaction, by controlling rightly reaction condition, prepare bone cement powder main body composition.On this basis toward adding a certain amount of hydroxyapatite in powder and the abundant mix homogeneously of silicate is prepared bone cement powder.Bone cement powder and the consolidation liquid that contains citric acid are in harmonious proportion by certain liquid-solid ratio, can obtain hardening time without significant prolongation or the neutral bone cement that shortens to some extent.
A preparation method for the neutral bone cement of series of calcium phosphate, is characterized in that, comprises the following steps:
(1) will after calcination in 900 ℃ of stoves after raw material mixing, ball milling, obtain bone cement powder main body composition;
(2) toward adding hydroxyapatite in bone cement powder main body composition and silicate is prepared bone cement powder;
(3) if bone cement powder for a long time need not, be stored in 4 ℃ of dry enclosed environments;
(4) bone cement powder and acid consolidation liquid are in harmonious proportion by liquid-solid ratio, can obtain the neutral bone cement of series of calcium phosphate.
The described raw material of step (1) is that mol ratio is that 2:0.90 is to calcium hydrogen phosphate and the calcium carbonate mixture of 2:1.15.
The described hydroxyapatite of step (2) is of a size of and is less than 5 mm, and its content in bone cement powder is 0.05-60%.
The described silicate of step (2) is a kind of or its combination in sodium silicate, potassium silicate, calcium silicates, and its content in bone cement is 0-30%.
The described dry enclosed environment of step (3) is that outside air can not directly contact with bone cement powder.
The described dry enclosed environment of step (3) is for to be placed in bone cement powder the inert gas environments such as nitrogen, argon, or after evacuation, is placed in exsiccator, electronic dry cabinet.
The described acid consolidation liquid of step (4) is that citric acid content is at the solution of 3-55%, or take it as basis interpolation 0.01-5% hydroxypropyl emthylcellulose, the sodium carboxymethyl cellulose of 0.01-2%, 0.01-4% chitosan, 0.01-2% gelatin, 0.01-1.5% polyvinyl alcohol, 0.01-10% Polyethylene Glycol, 0.01-2% sodium alginate, 0.01-5% starch, 0.01-1% hyaluronic acid, 0.01-2% collagen protein, 0.5-40% glycerol, 0.01-15% sodium sulfate, 0.01-15% potassium sulfate, 0.01-15% ammonium sulfate, 0.01-10% magnesium sulfate, 0.01-10% sodium chloride, 0.01-10% potassium chloride, 0.01-15% calcium chloride, 0.01-15% sodium glycerophosphate, 0.01-15% glucose, 0.01-15% mannose, a kind of or its combination wherein of 0.01-5% cyclodextrin.
The described liquid-solid ratio of step (4) is to add 0.30-0.70 milliliter consolidation liquid in every 1 gram of bone cement powder.
The neutral bone cement of series of calcium phosphate preparing according to method described in above-mentioned any one, its pH value is 5-9, after solidifying, apparent density is not less than 1.30 g/cm
3, defeated and dispersed coefficient is not more than 5%.
The present invention is grouped into and is prepared a kind of Bone Colonizable Cements In Rabbits powder by the regulation and control preparation technology of bone cement and one-tenth thereof.Gained bone cement powder can be consolidation liquid curing molding with citric acid effectively, keeps higher mechanical strength simultaneously.Preparation method provided by the invention is simple, easily capable, effective, be suitable for containing in the consolidation liquid system of citric acid and promoting the use of in difference, can large-scale application.
Apparent density method of testing is: first adopt the cylindrical mold of diameter 6 mm height 10 mm to prepare bone cement sample, then measure actual diameter, height and the quality of solidifying the bone cement sample after 24 hours, calculate its density and be apparent density.
The method of testing of defeated and dispersed coefficient is: after solidifying, bone cement soaks after 10 days quality and reduces percentage ratio as defeated and dispersed coefficient in water.
PH value method of testing containing bone cement aqueous solution is: the bone cement that 1.0 g were solidified after 24 hours is placed in 20 mL ultra-pure waters, then with pH meter, measures it at the pH value of different soak times.
Accompanying drawing explanation
Figure 1 shows that solidifying rear bone cement is placed on rear pH temporal evolution curve in water.
The specific embodiment
Following examples be take invention technical scheme and are implemented as prerequisite, provided detailed embodiment and concrete operating process, but protection scope of the present invention are not limited to following embodiment.
Embodiment 1:
Take 86 g calcium phosphate dibasic dihydrates and 25 g calcium carbonate, joined ball milling mix homogeneously in 165 mL water.Then by water distilling under reduced pressure, in 80 ℃ of vacuum drying ovens, be dried and obtain mixed powder.After burning 15 hours, 900 ℃ of stove stage casings adopt wet ball grinding to obtain bone cement dispersion liquid powder body.After dispersion liquid is centrifugal, dry, obtain bone cement powder main body composition, powder body is of a size of 300-800 nm.
Embodiment 2:
96 g bone cement powder main body compositions and 4 g hydroxyapatite are ground and evenly obtain bone cement powder with mortar.Consolidation liquid and bone cement powder that 20% citric acid-1% hydroxypropyl emthylcellulose is formed are in harmonious proportion by the liquid-solid ratio of 0.5 mL/g, and it is 11 min that reference standard ASTM C191 measures the presetting period.After solidifying, bone cement apparent density is 1.45 g/cm
3, defeated and dispersed coefficient is 1.5%.Be added to the water, it is neutral that solution is.After standing one week, test solution pH is substantially constant, and as shown in Figure 1, aqueous solution pH keeps neutral at long period yardstick always.
Embodiment 3:
91 g bone cement powder main body compositions and 4 g hydroxyapatite and 5 g sodium silicate are ground and evenly obtain bone cement powder with mortar.Consolidation liquid and bone cement powder that 20% citric acid-1% hydroxypropyl emthylcellulose is formed are in harmonious proportion by the liquid-solid ratio of 0.5 mL/g, and it is 9 min that reference standard ASTM C191 measures the presetting period.After solidifying, bone cement apparent density is 1.48 g/cm
3, defeated and dispersed coefficient 2.2%.Be added to the water, it is neutral that solution is.After standing one week, pH value of solution is substantially constant, similar shown in result and Fig. 1.
Claims (9)
1. a preparation method for the neutral bone cement of series of calcium phosphate, is characterized in that, comprises the following steps:
(1) will after calcination in 900 ℃ of stoves after raw material mixing, ball milling, obtain bone cement powder main body composition;
(2) toward adding hydroxyapatite in bone cement powder main body composition and silicate is prepared bone cement powder;
(3) if bone cement powder for a long time need not, be stored in 4 ℃ of dry enclosed environments;
(4) bone cement powder and acid consolidation liquid are in harmonious proportion by liquid-solid ratio, can obtain the neutral bone cement of series of calcium phosphate.
2. the preparation method of the neutral bone cement of series of calcium phosphate according to claim 1, is characterized in that, the described raw material of step (1) is that mol ratio is that 2:0.90 is to calcium hydrogen phosphate and the calcium carbonate mixture of 2:1.15.
3. the preparation method of the neutral bone cement of series of calcium phosphate according to claim 1, is characterized in that, the described hydroxyapatite of step (2) is of a size of and is less than 5 mm, and its content in bone cement powder is 0.05-60%.
4. the preparation method of the neutral bone cement of series of calcium phosphate according to claim 1, is characterized in that, the described silicate of step (2) is a kind of or its combination in sodium silicate, potassium silicate, calcium silicates, and its content in bone cement is 0-30%.
5. the preparation method of the neutral bone cement of series of calcium phosphate according to claim 1, is characterized in that, the described dry enclosed environment of step (3) is that outside air can not directly contact with bone cement powder.
6. the preparation method of the neutral bone cement of series of calcium phosphate according to claim 5, it is characterized in that, the described dry enclosed environment of step (3) is for to be placed in bone cement powder the inert gas environments such as nitrogen, argon, or after evacuation, is placed in exsiccator, electronic dry cabinet.
7. the preparation method of the neutral bone cement of series of calcium phosphate according to claim 1, it is characterized in that, the described acid consolidation liquid of step (4) is that citric acid content is at the solution of 3-55%, or take it as basis interpolation 0.01-5% hydroxypropyl emthylcellulose, the sodium carboxymethyl cellulose of 0.01-2%, 0.01-4% chitosan, 0.01-2% gelatin, 0.01-1.5% polyvinyl alcohol, 0.01-10% Polyethylene Glycol, 0.01-2% sodium alginate, 0.01-5% starch, 0.01-1% hyaluronic acid, 0.01-2% collagen protein, 0.5-40% glycerol, 0.01-15% sodium sulfate, 0.01-15% potassium sulfate, 0.01-15% ammonium sulfate, 0.01-10% magnesium sulfate, 0.01-10% sodium chloride, 0.01-10% potassium chloride, 0.01-15% calcium chloride, 0.01-15% sodium glycerophosphate, 0.01-15% glucose, 0.01-15% mannose, a kind of or its combination wherein of 0.01-5% cyclodextrin.
8. the preparation method of the neutral bone cement of series of calcium phosphate according to claim 1, is characterized in that, the described liquid-solid ratio of step (4) is to add 0.30-0.70 milliliter consolidation liquid in every 1 gram of bone cement powder.
9. the neutral bone cement of series of calcium phosphate preparing according to method described in claim 1-8 any one, its pH value is 5-9, after solidifying, apparent density is not less than 1.30 g/cm
3, defeated and dispersed coefficient is not more than 5%.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524627A (en) * | 2014-12-23 | 2015-04-22 | 南京航空航天大学 | Method for preparing high-strength novel hydroxyapatite bone cement |
| CN106267365A (en) * | 2016-08-17 | 2017-01-04 | 林春梅 | A kind of enhancing activity injecting bone cement and preparation method thereof |
| CN106540317A (en) * | 2016-12-08 | 2017-03-29 | 苏州艾博迈尔新材料有限公司 | A kind of realizing controlled-release bone cement and preparation method thereof |
| CN106620886A (en) * | 2016-12-09 | 2017-05-10 | 苏州纳贝通环境科技有限公司 | Liquid bracket material for bone repair and preparation method thereof |
| CN106729971A (en) * | 2016-11-23 | 2017-05-31 | 上海纳米技术及应用国家工程研究中心有限公司 | A kind of modified calcium phosphate bone cement of water-soluble mono wall carbon nano tube and preparation and application |
| CN108273131A (en) * | 2018-03-19 | 2018-07-13 | 深圳市中科海世御生物科技有限公司 | A kind of composite bone cement, preparation method and applications and a kind of bone renovating material |
| CN109498846A (en) * | 2018-10-09 | 2019-03-22 | 广州润虹医药科技股份有限公司 | Bone repairing support and preparation method thereof that is a kind of while discharging zinc ion and strontium ion |
| CN110201228A (en) * | 2019-04-19 | 2019-09-06 | 湖北联结生物材料有限公司 | A kind of calcium phosphate bone cement and its preparation method and application containing decalcified bone matrix |
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| CN104524627A (en) * | 2014-12-23 | 2015-04-22 | 南京航空航天大学 | Method for preparing high-strength novel hydroxyapatite bone cement |
| CN106267365A (en) * | 2016-08-17 | 2017-01-04 | 林春梅 | A kind of enhancing activity injecting bone cement and preparation method thereof |
| CN106729971A (en) * | 2016-11-23 | 2017-05-31 | 上海纳米技术及应用国家工程研究中心有限公司 | A kind of modified calcium phosphate bone cement of water-soluble mono wall carbon nano tube and preparation and application |
| CN106540317A (en) * | 2016-12-08 | 2017-03-29 | 苏州艾博迈尔新材料有限公司 | A kind of realizing controlled-release bone cement and preparation method thereof |
| CN106620886A (en) * | 2016-12-09 | 2017-05-10 | 苏州纳贝通环境科技有限公司 | Liquid bracket material for bone repair and preparation method thereof |
| CN108273131A (en) * | 2018-03-19 | 2018-07-13 | 深圳市中科海世御生物科技有限公司 | A kind of composite bone cement, preparation method and applications and a kind of bone renovating material |
| CN109498846A (en) * | 2018-10-09 | 2019-03-22 | 广州润虹医药科技股份有限公司 | Bone repairing support and preparation method thereof that is a kind of while discharging zinc ion and strontium ion |
| CN109498846B (en) * | 2018-10-09 | 2021-07-16 | 广州润虹医药科技股份有限公司 | Bone repair scaffold capable of releasing zinc ions and strontium ions simultaneously and preparation method thereof |
| CN110201228A (en) * | 2019-04-19 | 2019-09-06 | 湖北联结生物材料有限公司 | A kind of calcium phosphate bone cement and its preparation method and application containing decalcified bone matrix |
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