CN103656732A - Novel dressing and preparation method thereof - Google Patents
Novel dressing and preparation method thereof Download PDFInfo
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- CN103656732A CN103656732A CN201310669049.1A CN201310669049A CN103656732A CN 103656732 A CN103656732 A CN 103656732A CN 201310669049 A CN201310669049 A CN 201310669049A CN 103656732 A CN103656732 A CN 103656732A
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- glycerol
- propylene glycol
- dressing
- antibacterial peptide
- phenoxyethanol
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Abstract
The invention provides a liquid dressing. Every 100g of the dressing comprises the following components: 2-8g of propylene glycol, 1-5g of glycerol, 1-4g of antibacterial peptide, 0.05-0.2g of phenoxyethanol and the balance of purified water. The method for preparing the dressing comprises the following steps: 1, sequentially adding propylene glycol, glycerol, phenoxyethanol and purified water into a reaction container, heating to the temperature of 80 DEG C until the mixture is completely dissolved, and stirring and cooling; 2, predissolving the antibacterial peptide by using water at room temperature, adding the antibacterial peptide into the reaction container in the step 1, mixing the antibacterial peptide with the propylene glycol, glycerol and purified water, heating to the temperature of 90 DEG C, wherein the heating time does not exceed 10 minutes, uniformly stirring, and discharging. The dressing provided in the invention is obvious in disinfection and sterilization effects, simple in preparation process and low in price and has high application value.
Description
Technical field
The present invention relates to a kind of for wound or the dressing of wound surface sterilizing and the preparation method of this dressing.
Background technology
At present, for the wound infection that prevents that patient from being caused by burn, scald, open wound surface etc., usually need to add dressing in wound location carries out sterilizing, to urge into wound healing.Conventional dressing mostly is Powdered, but Powdered dressing poor permeability, can not effectively kill the antibacterial of wound surface deep layer; Also having and use liquid dressing, is main mainly with silver ion solvent, and the formula material needing is many, complicated process of preparation, and processing conditions is harsh, and expensive.
Summary of the invention
For addressing the above problem, the invention provides a kind of liquid dressing, dressing comprises described in every 100g:
Propylene glycol 2～8g
Glycerol 1～5g
Antibacterial peptide 1～4 g
Phenoxyethanol 0.05～0.2 g
All the other are pure water.
Preferably, described in every 100g, dressing comprises:
Propylene glycol 5g
Glycerol 3g
Antibacterial peptide 2g
Phenoxyethanol 0.1 g
All the other are pure water.
The present invention also provides the method for preparing above-mentioned dressing, comprises the following steps:
One, propylene glycol, glycerol, phenoxyethanol, pure water are joined in reaction vessel successively, be heated to 80 ℃ and dissolve completely, then stir cooling;
Two, at room temperature, antibacterial peptide is carried out to predissolve with pure water, join described in step 1 in reaction vessel, mix with propylene glycol, glycerol, water, be heated to 90 ℃, be no more than 10 minutes heat time heating time, stir, discharging.
Dressing sterilization effect provided by the invention is remarkable, and preparation technology is simple, and low price has very large using value.
The specific embodiment
Embodiment 1
A liquid dressing, dressing comprises described in every 100g: propylene glycol 2g, glycerol 1g, antibacterial peptide 4g, phenoxyethanol 0.05g, all the other are pure water.
Take according to quantity propylene glycol, glycerol, phenoxyethanol and appropriate pure water, join successively in reaction vessel, be heated to 80 ℃ and dissolve completely, then stir cooling.
At room temperature, antibacterial peptide is carried out to predissolve with pure water, join described in above-mentioned steps in reaction vessel, mix with propylene glycol, glycerol, water, be heated to 90 ℃, be no more than 10 minutes heat time heating time, stir, discharging.
Embodiment 2
A liquid dressing, dressing comprises described in every 100g: propylene glycol 8g, glycerol 5g, antibacterial peptide 1g, phenoxyethanol 0.2g, all the other are pure water.
Take according to quantity propylene glycol, glycerol, phenoxyethanol and appropriate pure water, join successively in reaction vessel, be heated to 80 ℃ and dissolve completely, then stir cooling.
At room temperature, antibacterial peptide is carried out to predissolve with pure water, join described in above-mentioned steps in reaction vessel, mix with propylene glycol, glycerol, water, be heated to 90 ℃, be no more than 10 minutes heat time heating time, stir, discharging.
Embodiment 3
A liquid dressing, dressing comprises described in every 100g: propylene glycol 5g, glycerol 3g, antibacterial peptide 2g, phenoxyethanol 0.1g, all the other are pure water.
Take according to quantity propylene glycol, glycerol, phenoxyethanol and appropriate pure water, join successively in reaction vessel, be heated to 80 ℃ and dissolve completely, then stir cooling.
At room temperature, antibacterial peptide is carried out to predissolve with pure water, join described in above-mentioned steps in reaction vessel, mix with propylene glycol, glycerol, water, be heated to 90 ℃, be no more than 10 minutes heat time heating time, stir, discharging.
Utilize the dressing finished product of above-described embodiment 1, embodiment 2, embodiment 3 gained as treatment group, in Foochow hospital, carry out clinical trial, and with the dressing of chitosan powder as a control group 1, silver ion solution dressing 2 is analyzed as a control group, result of the test is as shown in the table:
Compare with matched group 2 with matched group 1, participate in wound surface bacterial positive rate and reach 100% after burn, along with treatment time extends, bacterial positive rate constantly declines.Evaluation by bacteria culture shows, dressing provided by the present invention has significant inhibitory action to escherichia coli, staphylococcus aureus, bacillus pyocyaneus.Treatment group wound healing time is obviously short than matched group, and disinfection effect is outstanding, and wound healing position is level and smooth, has no adverse reaction and Drug resistance, and therefore, dressing provided by the present invention is a kind of more satisfactory dressing.
Claims (3)
1. a new pattern compress, is characterized in that, dressing comprises described in every 100g:
Propylene glycol 2～8g
Glycerol 1～5g
Antibacterial peptide 1～4 g
Phenoxyethanol 0.05～0.2 g
All the other are pure water.
2. a kind of new pattern compress as claimed in claim 1, is characterized in that, dressing comprises described in every 100g:
Propylene glycol 5g
Glycerol 3g
Antibacterial peptide 2g
Phenoxyethanol 0.1 g
All the other are pure water.
3. prepare a method for new pattern compress as claimed in claim 1 or 2, it is characterized in that, comprise the following steps:
One, propylene glycol, glycerol, phenoxyethanol, pure water are joined in reaction vessel successively, be heated to 80 ℃ and dissolve completely, then stir cooling;
Two, at room temperature, antibacterial peptide is carried out to predissolve with pure water, join described in step 1 in reaction vessel, mix with propylene glycol, glycerol, water, be heated to 90 ℃, be no more than 10 minutes heat time heating time, stir, discharging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310669049.1A CN103656732B (en) | 2013-12-11 | 2013-12-11 | A kind of new pattern compress and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310669049.1A CN103656732B (en) | 2013-12-11 | 2013-12-11 | A kind of new pattern compress and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103656732A true CN103656732A (en) | 2014-03-26 |
| CN103656732B CN103656732B (en) | 2016-08-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310669049.1A Active CN103656732B (en) | 2013-12-11 | 2013-12-11 | A kind of new pattern compress and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN103656732B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816904A (en) * | 2016-06-11 | 2016-08-03 | 顾银凤 | Medical antimicrobial gauze |
| CN106955291A (en) * | 2017-04-11 | 2017-07-18 | 皮定业 | A kind of anti-inflammation medicament and preparation method thereof |
| CN109106979A (en) * | 2018-09-11 | 2019-01-01 | 吉林省蓝鼎陆和科技有限公司 | A kind of tridecanoic peptide antiseptic dressing and preparation method thereof |
| CN111317853A (en) * | 2020-02-21 | 2020-06-23 | 牡丹江医学院 | Dressing for preventing and treating bedsore and preparation method thereof |
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| EP1304102A2 (en) * | 2001-10-17 | 2003-04-23 | Beiersdorf AG | Combination of retinoids and cyclodextrins in cosmetic or dermatological O/W-emulsions |
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| CN101623511A (en) * | 2009-07-31 | 2010-01-13 | 四川大学 | Moisturizing agent for biological dressing and preparation method thereof |
| CN102441158A (en) * | 2010-10-15 | 2012-05-09 | 天津瑞普生物技术股份有限公司 | Eye drop containing cecropin for pets and preparation method thereof |
| CN102716510A (en) * | 2011-03-30 | 2012-10-10 | 湖南安信医用高分子材料有限公司 | Moisture-retention nano-silver burn and scald plaster |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1304102A2 (en) * | 2001-10-17 | 2003-04-23 | Beiersdorf AG | Combination of retinoids and cyclodextrins in cosmetic or dermatological O/W-emulsions |
| CN101569760A (en) * | 2008-12-31 | 2009-11-04 | 褚加冕 | Preparation method for aloe gel healing promotion dressing |
| CN101623511A (en) * | 2009-07-31 | 2010-01-13 | 四川大学 | Moisturizing agent for biological dressing and preparation method thereof |
| CN102441158A (en) * | 2010-10-15 | 2012-05-09 | 天津瑞普生物技术股份有限公司 | Eye drop containing cecropin for pets and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816904A (en) * | 2016-06-11 | 2016-08-03 | 顾银凤 | Medical antimicrobial gauze |
| CN105816904B (en) * | 2016-06-11 | 2018-11-16 | 绍兴易邦医用品有限公司 | A kind of medical antibacterial gauze |
| CN106955291A (en) * | 2017-04-11 | 2017-07-18 | 皮定业 | A kind of anti-inflammation medicament and preparation method thereof |
| CN106955291B (en) * | 2017-04-11 | 2018-08-07 | 重庆立见科技发展有限责任公司 | A kind of antibacterial anti-inflammatory medicament and preparation method thereof |
| WO2018188197A1 (en) * | 2017-04-11 | 2018-10-18 | 重庆立见科技发展有限责任公司 | Antibacterial and anti-inflammatory drug and preparation method therefor |
| CN109106979A (en) * | 2018-09-11 | 2019-01-01 | 吉林省蓝鼎陆和科技有限公司 | A kind of tridecanoic peptide antiseptic dressing and preparation method thereof |
| CN111317853A (en) * | 2020-02-21 | 2020-06-23 | 牡丹江医学院 | Dressing for preventing and treating bedsore and preparation method thereof |
| CN111317853B (en) * | 2020-02-21 | 2021-03-19 | 牡丹江医学院 | A kind of dressing for preventing and treating bedsore and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103656732B (en) | 2016-08-17 |
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