CN103655003A - Foldable posterior chamber fixed type artificial lens and preparing method thereof - Google Patents
Foldable posterior chamber fixed type artificial lens and preparing method thereof Download PDFInfo
- Publication number
- CN103655003A CN103655003A CN201310678096.2A CN201310678096A CN103655003A CN 103655003 A CN103655003 A CN 103655003A CN 201310678096 A CN201310678096 A CN 201310678096A CN 103655003 A CN103655003 A CN 103655003A
- Authority
- CN
- China
- Prior art keywords
- chamber fixed
- artificial lens
- fixed type
- posterior chamber
- foldable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title abstract description 5
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims abstract description 7
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims abstract description 7
- NGWSAUQBWVWFCU-UHFFFAOYSA-N n-ethyl-2,3-dimethylbutan-2-amine Chemical compound CCNC(C)(C)C(C)C NGWSAUQBWVWFCU-UHFFFAOYSA-N 0.000 claims abstract description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 5
- 239000013078 crystal Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 6
- 230000003287 optical effect Effects 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract 2
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 208000002177 Cataract Diseases 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000007943 implant Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
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- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a foldable posterior chamber fixed type artificial lens and a preparing method of the foldable posterior chamber fixed type artificial lens. The foldable posterior chamber fixed type artificial lens comprises an artificial lens optical portion body and a C-shaped supporting piece. The artificial lens optical portion body 1 is a circular thin sheet made of acrylamide, double-fork methacrylamide, ammonium persulfate and tetramethyl diethylamine, wherein the middle of the circular thin sheet is thick and the periphery is thin. The preparing method comprises the steps that 2 to 3g of the acrylamide, 0.5 to 1g of the double-fork methacrylamide and 0.1g of the ammonium persulfate dissolve in 20ml of normal saline, the tetramethyl diethylamine is then added and mixed evenly, a mixture is poured in a C-shaped lens mold and placed in the environment with the temperature of 30 DEG C for one hour, and after the mixture is solidified, the foldable posterior chamber fixed type artificial lens is obtained. The foldable posterior chamber fixed type artificial lens has the advantages of being stable in inertia, foldable, good in optical transparency, small in elasticity and safe in surgery operation.
Description
technical field:
The present invention relates to a kind of artificial intraocular lenses's design and preparation field, relate in particular to a kind of collapsible rear chamber fixed pattern artificial intraocular lenses design and preparation field.
technical background:
Intraocular lens implants is the most effective means such as treatment cataract, is also the method the most thoroughly of correcting defects of vision.
Present hard artificial intraocular lenses, this crystal can not fold, and needs an otch (about 6 mms) identical with crystal optics portion size during operation, crystal could be implanted to ophthalmic.Along with phacoemulsification technology develops rapidly, cataract ultrasonic emulsification is with ultrasonic energy, crystal nuclear to be pulverized and emulsifying sucking-off, and by this otch implantable artificial crystal.Operative doctor can only have been used the otch that 3.2 mm are even less just can remove cataract, but also needs to expand otch when laying artificial intraocular lenses, could implant.In order to adapt to the progress of operation, improve artificial intraocular lenses's material, making diameter is that the artificial intraocular lenses of 6 mm can doubling, even curling, by implanting tweezer or implantation device, implanted, after entering ophthalmic, folding artificial intraocular lenses understands Automatic-expanding, is supported on the position of appointment.Therefore, soft collapsible artificial intraocular lenses, receives publicity.
Artificial crystal material is the material in implantable bioartificial body, needs physicochemical property stable, can with body tissue harmonious coexistence, body is had no side effect, nonirritant, do not cause the immunoreation (biocompatibility) of body, and index of refraction is identical with the index of refraction of normal lens.Present stage, lacks biocompatibility little, the soft collapsible artificial intraocular lenses that physicochemical property is stable, and the soft collapsible artificial intraocular lenses of development of new seems particularly important.
summary of the invention:
Goal of the invention: design the collapsible artificial intraocular lenses of a kind of new type soft, have biocompatibility little, physicochemical property is stable, soft folding feature.
Technical scheme:
The invention provides a kind of collapsible rear chamber fixed pattern artificial intraocular lenses and preparation method thereof.Technical scheme comprises that intraocular lens optic portion main body and C type support loop, and wherein intraocular lens optic portion 1 main body is thick middle, around thin thin rounded flakes.Preparation method is by acrylamide 2-3g, and two fork Methacrylamide 0.5-1g and 0.1g Ammonium persulfate. are dissolved in 20ml normal saline, then adds tetramethyl diethylamine to mix, and pours in C type crystal mould, is placed in 30 ℃, 1hr.After solidifying, obtain.
Accompanying drawing explanation
Accompanying drawing 1 artificial intraocular lenses's illustraton of model.1. intraocular lens optic portion; 2. C type supports loop.
useful benefit:
Artificial intraocular lenses prepared by the present invention, has stable inertia, collapsible, optical transparence, and its elasticity is less, operation technique safety.
the specific embodiment:
embodiment 1:by acrylamide 2g, two fork Methacrylamide 1g and 0.1g Ammonium persulfate. are dissolved in 20ml normal saline, then add tetramethyl diethylamine to mix, and pour in C type crystal mould, are placed in 30 ℃, 1hr.After solidifying, obtain.
embodiment 2:by acrylamide 3g, two fork Methacrylamide 0.5g and 0.1g Ammonium persulfate. are dissolved in 20ml normal saline, then add tetramethyl diethylamine to mix, and pour in C type crystal mould, are placed in 30 ℃, 1hr.After solidifying, obtain.
Claims (3)
1. a collapsible rear chamber fixed pattern artificial intraocular lenses, is characterized in that: comprise intraocular lens optic portion 1 main body, C type supports loop 2, and wherein intraocular lens optic portion 1 main body is thick middle, around thin thin rounded flakes.
2. a collapsible rear chamber fixed pattern artificial intraocular lenses, is characterized in that: by acrylamide, and two fork Methacrylamides, Ammonium persulfate., tetramethyl diethylamine forms.
3. collapsible rear chamber fixed pattern artificial intraocular lenses preparation method: it is characterized in that: by acrylamide 2-3g, two fork Methacrylamide 0.5-1g and 0.1g Ammonium persulfate. are dissolved in 20ml normal saline, add again tetramethyl diethylamine to mix, pour in C type crystal mould, be placed in 30 ℃, 1hr, after solidifying, obtains.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310678096.2A CN103655003A (en) | 2013-12-13 | 2013-12-13 | Foldable posterior chamber fixed type artificial lens and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310678096.2A CN103655003A (en) | 2013-12-13 | 2013-12-13 | Foldable posterior chamber fixed type artificial lens and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103655003A true CN103655003A (en) | 2014-03-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310678096.2A Pending CN103655003A (en) | 2013-12-13 | 2013-12-13 | Foldable posterior chamber fixed type artificial lens and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103655003A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106956082A (en) * | 2016-01-11 | 2017-07-18 | 广东东阳光药业有限公司 | Artificial lens preparation method |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4412359A (en) * | 1982-04-26 | 1983-11-01 | Myers William D | Posterior chamber lens implant |
| US4750904A (en) * | 1986-03-31 | 1988-06-14 | Price Jr Francis W | Posterior chamber intraocular lens with improved fixation where the posterior capsule is not present to serve as a fixation platform |
| CN1219179A (en) * | 1996-03-25 | 1999-06-09 | 法玛西亚－艾尔维森公司 | High refractive index hydrogels prepared from polymers and copolymers of N-benzyl-N-methylacrylamide |
| US6179870B1 (en) * | 1996-05-03 | 2001-01-30 | Corneal Laboratoires | Flexible intraocular implant formed in one piece |
| CN1293578A (en) * | 1998-03-16 | 2001-05-02 | 法玛西雅厄普约翰格罗宁根有限公司 | Method and materials for producing intracular lenses |
| EP1457170A1 (en) * | 2003-03-13 | 2004-09-15 | GenioVis GmbH | Posterior chamber intraocular lens |
| US20090124955A1 (en) * | 2006-05-25 | 2009-05-14 | Ayyala Ramesh S | Device for delivery of antifibrotic agents & method |
-
2013
- 2013-12-13 CN CN201310678096.2A patent/CN103655003A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4412359A (en) * | 1982-04-26 | 1983-11-01 | Myers William D | Posterior chamber lens implant |
| US4750904A (en) * | 1986-03-31 | 1988-06-14 | Price Jr Francis W | Posterior chamber intraocular lens with improved fixation where the posterior capsule is not present to serve as a fixation platform |
| CN1219179A (en) * | 1996-03-25 | 1999-06-09 | 法玛西亚－艾尔维森公司 | High refractive index hydrogels prepared from polymers and copolymers of N-benzyl-N-methylacrylamide |
| US6179870B1 (en) * | 1996-05-03 | 2001-01-30 | Corneal Laboratoires | Flexible intraocular implant formed in one piece |
| CN1293578A (en) * | 1998-03-16 | 2001-05-02 | 法玛西雅厄普约翰格罗宁根有限公司 | Method and materials for producing intracular lenses |
| EP1457170A1 (en) * | 2003-03-13 | 2004-09-15 | GenioVis GmbH | Posterior chamber intraocular lens |
| US20090124955A1 (en) * | 2006-05-25 | 2009-05-14 | Ayyala Ramesh S | Device for delivery of antifibrotic agents & method |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106956082A (en) * | 2016-01-11 | 2017-07-18 | 广东东阳光药业有限公司 | Artificial lens preparation method |
| WO2017121311A1 (en) * | 2016-01-11 | 2017-07-20 | 广东东阳光药业有限公司 | Method for preparing intraocular lens |
| CN108472130A (en) * | 2016-01-11 | 2018-08-31 | 广东东阳光药业有限公司 | Artificial lens preparation method |
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| PB01 | Publication | ||
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| C12 | Rejection of a patent application after its publication | ||
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Application publication date: 20140326 |