CN103638441A - 一种治疗肝郁脾虚型脂肪肝的中药组合物 - Google Patents
一种治疗肝郁脾虚型脂肪肝的中药组合物 Download PDFInfo
- Publication number
- CN103638441A CN103638441A CN201310722886.6A CN201310722886A CN103638441A CN 103638441 A CN103638441 A CN 103638441A CN 201310722886 A CN201310722886 A CN 201310722886A CN 103638441 A CN103638441 A CN 103638441A
- Authority
- CN
- China
- Prior art keywords
- radix
- liver
- parts
- traditional chinese
- medicinal composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000004930 Fatty Liver Diseases 0.000 title claims abstract description 24
- 206010019708 Hepatic steatosis Diseases 0.000 title claims abstract description 24
- 208000010706 fatty liver disease Diseases 0.000 title claims abstract description 24
- 231100000240 steatosis hepatitis Toxicity 0.000 title claims abstract description 24
- 210000004185 liver Anatomy 0.000 title claims abstract description 21
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 210000000952 spleen Anatomy 0.000 title abstract description 10
- 208000024891 symptom Diseases 0.000 title abstract description 8
- 230000007812 deficiency Effects 0.000 title abstract description 7
- 239000003814 drug Substances 0.000 claims abstract description 29
- 241000726094 Aristolochia Species 0.000 claims abstract description 3
- 241001522303 Acanthis Species 0.000 claims description 10
- 241000628997 Flos Species 0.000 claims description 10
- 230000002792 vascular Effects 0.000 claims description 10
- 239000009526 Fructus Akebiae Substances 0.000 claims description 8
- 241000722953 Akebia Species 0.000 claims description 2
- 241000132446 Inula Species 0.000 claims description 2
- 241001299723 Limonia <Rutaceae> Species 0.000 claims description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 12
- 239000008280 blood Substances 0.000 abstract description 12
- 210000004369 blood Anatomy 0.000 abstract description 12
- 208000026435 phlegm Diseases 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 8
- 230000001105 regulatory effect Effects 0.000 abstract description 8
- 238000009825 accumulation Methods 0.000 abstract description 3
- 206010012335 Dependence Diseases 0.000 abstract description 2
- 238000005728 strengthening Methods 0.000 abstract description 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 240000008027 Akebia quinata Species 0.000 abstract 1
- 235000007756 Akebia quinata Nutrition 0.000 abstract 1
- 241001127714 Amomum Species 0.000 abstract 1
- 240000000058 Argemone mexicana Species 0.000 abstract 1
- 241000644318 Calcicola Species 0.000 abstract 1
- 235000005979 Citrus limon Nutrition 0.000 abstract 1
- 244000131522 Citrus pyriformis Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 244000116484 Inula helenium Species 0.000 abstract 1
- 235000002598 Inula helenium Nutrition 0.000 abstract 1
- 241001096084 Lactuca canadensis Species 0.000 abstract 1
- 241000511967 Tylophora Species 0.000 abstract 1
- 241000330755 Tylosema fassoglense Species 0.000 abstract 1
- 235000018907 Tylosema fassoglense Nutrition 0.000 abstract 1
- BBFQZRXNYIEMAW-UHFFFAOYSA-N aristolochic acid I Chemical compound C1=C([N+]([O-])=O)C2=C(C(O)=O)C=C3OCOC3=C2C2=C1C(OC)=CC=C2 BBFQZRXNYIEMAW-UHFFFAOYSA-N 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 7
- 230000037396 body weight Effects 0.000 description 4
- 238000002604 ultrasonography Methods 0.000 description 4
- 230000000994 depressogenic effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010019799 Hepatitis viral Diseases 0.000 description 2
- 208000032023 Signs and Symptoms Diseases 0.000 description 2
- 230000035508 accumulation Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 201000001862 viral hepatitis Diseases 0.000 description 2
- 208000004611 Abdominal Obesity Diseases 0.000 description 1
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 1
- 108010082126 Alanine transaminase Proteins 0.000 description 1
- 208000022309 Alcoholic Liver disease Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 description 1
- 206010065941 Central obesity Diseases 0.000 description 1
- 208000008964 Chemical and Drug Induced Liver Injury Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010072268 Drug-induced liver injury Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- 108020004206 Gamma-glutamyltransferase Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000017170 Lipid metabolism disease Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010041519 Spider naevus Diseases 0.000 description 1
- 231100000643 Substance intoxication Toxicity 0.000 description 1
- 206010043298 Testicular atrophy Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 201000010788 atrophy of testis Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000008195 breast development Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 231100000594 drug induced liver disease Toxicity 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 102000006640 gamma-Glutamyltransferase Human genes 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 235000005955 light diet Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 235000021476 total parenteral nutrition Nutrition 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 102000014898 transaminase activity proteins Human genes 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗肝郁脾虚型脂肪肝的中药组合物。脂肪肝属于中医“积聚”、“胁痛”、“痰湿”、“肝癖”范畴。中医认为肝郁脾虚型脂肪肝系肝脾气虚，功能减退所致。本发明选择具有疏肝理气健脾、辅以化瘀祛痰的中药春砂花、八月札、橘络、化香树果、青香藤、甘松、土木香、黔羊蹄甲、老鼠竻、三十六荡、水紫菀、柠檬叶，按传统方法制成汤剂，经临床试验，总有效率达到97.6％，而且无副作用，无复发，治疗效果稳定。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗肝郁脾虚型脂肪肝的中药组合物。
背景技术
脂肪肝是指各种原因引起的肝细胞内脂肪堆积的常见临床现象。绝大多数的脂肪肝是甘油三脂(TG)的堆积所致。多见于肥胖、大量饮酒及其它疾病患者。轻型脂肪肝患者可无症状，但大多数病人有程度不同的肝区疼痛。少数病人可伴有轻度黄疸，严重情况下可有蜘蛛痣、乳房发育、月经过多、闭经、睾丸萎缩、阳痿等。由于西药存在一定的副作用，且迄今为止并无特效的方法和药物，故国内外不少学者，冀希于从中医中药、中西医结合或天然药物角度寻求治疗脂肪肝的新方法和新药物，中医药对脂肪肝的临床症状体征好转或消失、降血脂、肝脏回缩及肝功能复常、降低体重等方面均有较好的疗效，具有作用广泛、效果稳定、使用安全、不良反应小、适宜长期服用的特点。
发明内容
本发明的目的是提供一种肝郁脾虚型脂肪肝的中药组合物。脂肪肝属于中医“积聚”、“胁痛”、“痰湿”、“肝癖”范畴。在辨证论治的基础上，脂肪肝的治疗法则应遵循《素问.至真要大论》所谓：“坚者消之，结者散之，留者攻之，逸者行之，衰者补之，容者除之”。在此原则指导之下，对本病区分标本虚实，虚则补之，实则湾之。因此中医治疗该病应当分清病因，辨证施治。肝郁脾虚型脂肪肝系肝脾气虚，功能减退所致，治疗原则为疏肝理气健脾、辅以化瘀祛痰。
本发明的目的是通过以下技术方案实现的，该治疗肝郁脾虚型脂肪肝的中药组合物由以下重量份的中药制成：春砂花2-3份、八月札15-30份、橘络3-5份、化香树果9-18份、青香藤6-9份、甘松2-4份、土木香3-6份、黔羊蹄甲6-9份、老鼠竻30-60份、三十六荡3-9份、水紫菀6-9份、柠檬叶9-15份。
优选的：春砂花2.5份、八月札20份、橘络4份、化香树果14份、青香藤7份、甘松3份、土木香5份、黔羊蹄甲7份、老鼠竻45份、三十六荡6份、水紫菀7份、柠檬叶12份。
制备方法将上述中药水煎制成汤剂。
方中：春砂花宽胸理气、祛痰平喘；八月札疏肝理气、活血止痛、除烦利尿；橘络理气化痰通络；化香树果顺气止痛、化痰祛风消肿；青香藤行气止痛、健脾；甘松理气止痛、醒脾健胃；土木香行气止痛、健脾和胃；黔羊蹄甲理气止痛、化痰利水；老鼠竻除痰消肿、散瘀止痛；三十六荡祛风化痰、解毒散瘀；水紫菀止咳化痰祛风；柠檬叶化痰、理气开胃。
临床资料
1.一般资料 选取42例脂肪肝患者均为2011年1月到2012年1月门诊就诊患者，诊断符合2006年《中华医学会肝脏病学分会脂肪肝和酒精性肝病学组》制定的诊断标准，并排除病毒性肝炎、自身免疫性肝炎、及药物中毒性肝炎等疾病。男28例，女14例，年龄19-68岁，平均年龄46.2岁，平均病程4.5年。
2.诊断标准 (1)无饮酒史或饮酒折合乙醇量男性每周140克，女性70克；(2)排除病毒性肝炎、药物性肝病、全胃肠外营养、肝豆状核变性等可导致脂肪肝的特定疾病。(3)除原发疾病临床表现外，有乏力、消化不良、肝区隐痛、肝脾肿大等非特异性症状及体征。(4)可有超重／内脏性肥胖、空腹血糖增高、血脂紊乱、高血压等代谢综合征。(5)血清转氨酶和谷氨酰转肽酶水平可由轻至中度增高(小于5倍正常值上限)，通常以丙氨酸氨基转移酶(即过去俗称的“GPT”)升高为主。(6)中医诊断标准：右胁胀痛，胁下痞块，胸闷腹胀，食欲减退，大便不实或溏，精神不振，舌苔薄白。
3.治疗方法 患者治疗期间，制定个体化饮食计划及合理运动方案，控制体重，不应用其他保肝、降脂等药物。在此基础上服用本发明所述的中药制剂，称取春砂花2.5g、八月札20g、橘络4g、化香树果14g、青香藤7g、甘松3g、土木香5g、黔羊蹄甲7g、老鼠竻45g、三十六荡6g、水紫菀7g、柠檬叶12g。水煎成汤剂，每日一剂，分早晚2次服用，连服3个月。
4.疗效标准 治愈：症状体征消失，B超检查肝脏大小正常，回声均匀，肝血管清晰；血脂三项均正常。显效：症状体征消失，B超检查肝脏大小正常，回声稍增强，肝血管清晰；血脂三项正常。有效：症状体征减轻，B超检查和血脂化验检查略有好转。无效：症状体征不变，B超检查和实验室检查指标未改善。
5.治疗效果 治疗3个月后进行效果评价，治愈21例(50％)，显效8例(19％)，有效12例(28.6％)，无效1例(2.4％)，总有效率97.6％。服药期间所有病例无不良反应，一年后随访无复发。
6.典型病例 李某，男，38岁，2012年2月1日初诊。患者查体发现脂肪肝，既往有乙肝病史，未做治疗，平日嗜酒。近因体重不断增加，乏力来就诊，见患者体胖，身高168cm，体重93kg，右胁隐痛，乏力，便溏，胃纳一般，小便正常，舌质淡肥有齿印，苔白，脉弦滑。生化检验示：HbsAg+，TC10.8mmol／L(3.6～6.1mmol／L)，TG4.1mmol／L(0.56～1.70mm／L)，HDL0.36mmol／L(0.40～2.00mmol／L)，肝功能正常。B超示：重度脂肪肝。中医诊断：胁痛肝郁脾虚。西医诊断：脂肪肝、乙肝病毒携带者。中药治疗以疏肝理气健脾为主、辅以化瘀祛痰。方药：称取春砂花2.5g、八月札20g、橘络4g、化香树果14g、青香藤7g、甘松3g、土木香5g、黔羊蹄甲7g、老鼠竻45g、三十六荡6g、水紫菀7g、柠檬叶12g。水煎成汤剂，每日一剂，分早晚2次服用。嘱患者加强体育锻炼，清淡饮食，忌饮酒。治疗3个月后患者症状消失，体重下降明显。血脂检验正常，B超示：轻度脂肪肝。
具体实施方式
实施例一：称取春砂花2.5g、八月札20g、橘络4g、化香树果14g、青香藤7g、甘松3g、土木香5g、黔羊蹄甲7g、老鼠竻45g、三十六荡6g、水紫菀7g、柠檬叶12g，将上述中药水煎成汤剂。
实施例二：称取春砂花3g、八月札15g、橘络5g、化香树果9g、青香藤9g、甘松2g、土木香6g、黔羊蹄甲6g、老鼠竻60g、三十六荡3g、水紫菀9g、柠檬叶9g，将上述中药水煎成汤剂。
实施例三：称取春砂花2g、八月札30g、橘络3g、化香树果18g、青香藤6g、甘松4g、土木香3g、黔羊蹄甲9g、老鼠竻30g、三十六荡9g、水紫菀6g、柠檬叶15g，将上述中药水煎成汤剂。
Claims (2)
1.一种治疗肝郁脾虚型脂肪肝的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：春砂花2-3份、八月札15-30份、橘络3-5份、化香树果9-18份、青香藤6-9份、甘松2-4份、土木香3-6份、黔羊蹄甲6-9份、老鼠竻30-60份、三十六荡3-9份、水紫菀6-9份、柠檬叶9-15份。
2.根据权利要求1所述的一种治疗肝郁脾虚型脂肪肝的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：春砂花2.5份、八月札20份、橘络4份、化香树果14份、青香藤7份、甘松3份、土木香5份、黔羊蹄甲7份、老鼠竻45份、三十六荡6份、水紫菀7份、柠檬叶12份。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310722886.6A CN103638441B (zh) | 2013-12-15 | 2013-12-15 | 一种治疗肝郁脾虚型脂肪肝的中药组合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310722886.6A CN103638441B (zh) | 2013-12-15 | 2013-12-15 | 一种治疗肝郁脾虚型脂肪肝的中药组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103638441A true CN103638441A (zh) | 2014-03-19 |
| CN103638441B CN103638441B (zh) | 2016-08-03 |
Family
ID=50243813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310722886.6A Expired - Fee Related CN103638441B (zh) | 2013-12-15 | 2013-12-15 | 一种治疗肝郁脾虚型脂肪肝的中药组合物 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103638441B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105727138A (zh) * | 2016-03-24 | 2016-07-06 | 成都富豪斯生物科技有限公司 | 一种治疗肝郁脾虚型脂肪肝的中药组合物及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188649A (zh) * | 2011-05-16 | 2011-09-21 | 高兵 | 一种治疗肉积型高脂血症的中药制备方法 |
| CN102198213A (zh) * | 2011-05-16 | 2011-09-28 | 高向东 | 一种治疗酗酒型三酸甘油酯增高症的中药制备方法 |
-
2013
- 2013-12-15 CN CN201310722886.6A patent/CN103638441B/zh not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188649A (zh) * | 2011-05-16 | 2011-09-21 | 高兵 | 一种治疗肉积型高脂血症的中药制备方法 |
| CN102198213A (zh) * | 2011-05-16 | 2011-09-28 | 高向东 | 一种治疗酗酒型三酸甘油酯增高症的中药制备方法 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105727138A (zh) * | 2016-03-24 | 2016-07-06 | 成都富豪斯生物科技有限公司 | 一种治疗肝郁脾虚型脂肪肝的中药组合物及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103638441B (zh) | 2016-08-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103007191B (zh) | 一种治疗黄疸的中药组合物 | |
| CN103446544A (zh) | 一种治疗肝硬化的中药丸剂 | |
| CN103536742B (zh) | 一种治疗慢性肠胃炎症的药物组合物及其制备方法 | |
| CN100998722B (zh) | 一种治疗月经后期痛经的内服中药 | |
| CN102698207A (zh) | 一种治疗肝病的中药组合物及其制备方法 | |
| CN101745047A (zh) | 一种治疗痛风病的中药组合物及制备方法 | |
| CN104784538B (zh) | 一种治疗糖尿病的中药制剂及制备方法 | |
| CN101104038A (zh) | 一种治疗肝气郁结型胆道蛔虫症的汤剂药物及制备方法 | |
| CN107927781B (zh) | 一种中药减肥代餐 | |
| CN101904985A (zh) | 一种治疗皮肤瘙痒的药物及其制备方法 | |
| CN100998719B (zh) | 一种治疗气滞血瘀型闭经的内服中药 | |
| CN103638441B (zh) | 一种治疗肝郁脾虚型脂肪肝的中药组合物 | |
| CN102949659A (zh) | 一种治疗乙型肝炎的中药组合物 | |
| CN104689239A (zh) | 一种治疗胆石症的中药组合物及其制备方法 | |
| CN102935183B (zh) | 一种治疗小儿病毒性肝炎的汤剂 | |
| CN1994415B (zh) | 一种治疗痛经的内服中药 | |
| CN103479960A (zh) | 治疗慢性乙肝病的中草药 | |
| CN102406906A (zh) | 一种治疗急性乙型肝炎的中药组合物 | |
| CN103212033B (zh) | 一种治疗病毒性肝炎的药物组合物 | |
| CN101015671B (zh) | 一种治疗肝硬化的中成药 | |
| CN102240384B (zh) | 一种治疗痰瘀互结型癫痫的药物及其制备方法 | |
| CN102233004B (zh) | 一种治疗肝病的药物 | |
| CN100998720B (zh) | 一种治疗胞宫瘀滞型闭经的内服中药 | |
| CN1994452A (zh) | 一种治疗原发性痛经的内服中药 | |
| CN114796434A (zh) | 内正邪不干丸 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Jimin Inventor after: Lin Zhihui Inventor before: Du Jichang |
|
| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160525 Address after: 264000 Yantai Dongfang Hospital, Jiefang Road 69, Zhifu District, Shandong, Yantai Applicant after: Zhang Jimin Applicant after: Lin Zhihui Address before: 276308 Yinan Hospital of traditional Chinese medicine, middle of Xianghe Road, Yinan County, Shandong, Linyi Applicant before: Du Jichang |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160803 Termination date: 20171215 |