CN103623003A - Pearl eye drops for improving eyesight and preparation method thereof - Google Patents
Pearl eye drops for improving eyesight and preparation method thereof Download PDFInfo
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- CN103623003A CN103623003A CN201310404998.7A CN201310404998A CN103623003A CN 103623003 A CN103623003 A CN 103623003A CN 201310404998 A CN201310404998 A CN 201310404998A CN 103623003 A CN103623003 A CN 103623003A
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Abstract
The invention discloses pearl eye drops for improving eyesight and a preparation method thereof. Particularly, butanediol is added to the prescription of the preparation, so that dry eyes are effectively relieved, and stimulus response caused by ethanol in the traditional formula can be reduced. Thus, the side effect of the medicine is reduced.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, be specifically related to a kind of ZHENZHU MINGMU DIYANYE and preparation method thereof.
Background technology
ZHENZHU MINGMU DIYANYE is made by Margarita hydrolyzed solution and Borneolum Syntheticum compatibility, and in Margarita hydrolyzed solution, Main Ingredients and Appearance is Margarita, and Margarita has tranquilizing mind, and yin nourishing is flame-out, heat clearing away tunnel expectorant, removing nebula improving eyesight, the function of removing toxic substances and promoting granulation.Borneolum Syntheticum has logical all keys, loose stagnated fire, removing nebula improving eyesight, the function of reducing swelling and alleviating pain; Borneolum Syntheticum through mucous membrane, subcutaneous tissue all easily absorbs.Clinical asthenopia disease and the chronic conjunctivitis of being mainly used in of ZHENZHU MINGMU DIYANYE, can improve that ophthalmic bloated, ophthalmic pruritus, ophthalmalgia, eye are dry, the puckery symptom such as can not read lastingly of eye.
Current existing disclosed patent CN200410067013.7 ZHENZHU MINGMU DIYANYE and preparation method thereof, it mainly adopts in ZHENZHU MINGMU DIYANYE preparation prescription and adds thickening agent, increases time of staying within the eye of medicine and improves drug effect.
Summary of the invention
Technical problem to be solved by this invention, is to provide ZHENZHU MINGMU DIYANYE and preparation method thereof, and its preparation technology is simple, adds butanediol to interfere by easing eyes, solves ethanol in former ZHENZHU MINGMU DIYANYE and brings the problems such as stimulation.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows:
A ZHENZHU MINGMU DIYANYE, is characterized in that the prescription of said preparation is: every 1000mL specifically consists of:
Margarita liquid 10mL,
Borneolum Syntheticum 1.0g,
Ethyl hydroxybenzoate 0.5g,
Hyaluronic acid sodium 2g,
Butanediol 3-6mL,
Sodium chloride 8.9g,
All the other are water for injection.
Preferably, a kind of ZHENZHU MINGMU DIYANYE, every 1000mL specifically consists of:
Margarita liquid 10mL,
Borneolum Syntheticum 1.0g,
Ethyl hydroxybenzoate 0.5g,
Hyaluronic acid sodium 2g,
Butanediol 5mL,
Sodium chloride 8.9g,
All the other are water for injection.
Above-described a kind of ZHENZHU MINGMU DIYANYE, is characterized in that its preparation method is prepared according to the following steps:
1) sodium chloride is added in appropriate water for injection, heated and boiled, is cooled to 80 ℃ to add Margarita liquid, and limit edged is cooled to 60 ℃, mixes, standby;
2) Borneolum Syntheticum, ethyl hydroxybenzoate are dissolved in to butanediol, add while stirring step 1) in solution, add water and stir 45min;
3) hyaluronic acid sodium is added to step 2) in solution, it is dissolved completely, regulate pH to 5.5～7.5, filter, filling jetting is to 1000ml.
Beneficial effect: the present invention compared with the prior art tool has the following advantages: use butanediol instead of ethanol in the prescription of ZHENZHU MINGMUYE, effectively easing eyes is dry and astringent, avoids the zest effect of ethanol simultaneously.
The specific embodiment
The concrete technical scheme of implementing of the present invention is:
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present invention all belong to scope of the present invention.General explanation, the Margarita liquid in the present invention is the extracting solution of Margarita powder.
Embodiment 1 ZHENZHU MINGMU DIYANYE and preparation method thereof
(1) prescription: every 1000mL specifically consists of:
Margarita liquid 10mL,
Borneolum Syntheticum 1.0g,
Ethyl hydroxybenzoate 0.5g,
Hyaluronic acid sodium 2g,
Butanediol 6mL,
Sodium chloride 8.9g,
All the other are water for injection.
(2) preparation of Margarita liquid: take 10kg Margarita powder, add in 80kg water for injection, be heated to 98 ℃, while supersound process 10min, intermittently operated three times, insulation 2h, then the sheet frame filter through 0.45 μ m microporous filter membrane filters to obtain Margarita liquid, measures described Margarita liquid protein content and is greater than 2.0mg/mL.
(3) ZHENZHU MINGMU DIYANYE preparation: 1. 8.9g sodium chloride is added in appropriate water for injection, heated and boiled, is cooled to 80 ℃ to add Margarita liquid 10mL, and limit edged is cooled to 60 ℃, mixes, standby; 2. get 1.0g Borneolum Syntheticum, 0.5g ethyl hydroxybenzoate is dissolved in 5ml butanediol, adds while stirring step 1. in solution; 3. hyaluronic acid sodium is dissolved in to 2. mixing and stirring in solution of step, regulates pH to 6, inject and be diluted with water to 1000mL, 0.22 μ m filter membrane filters, subpackage and get final product.
Embodiment 2 ZHENZHU MINGMU DIYANYE and preparation method thereof
(1) prescription: every 1000mL specifically consists of:
Margarita liquid 10mL,
Borneolum Syntheticum 1.0g,
Ethyl hydroxybenzoate 0.5g,
Hyaluronic acid sodium 2g,
Butanediol 3mL,
Sodium chloride 8.9g,
All the other are water for injection.
(2) preparation of Margarita liquid: take 10kg Margarita powder, add in 80kg water for injection, be heated to 98 ℃, while supersound process 10min, intermittently operated three times, insulation 2h, then the sheet frame filter through 0.45 μ m microporous filter membrane filters to obtain Margarita liquid, measures described Margarita liquid protein content and is greater than 2.0mg/mL.
(3) ZHENZHU MINGMU DIYANYE preparation: 1. 8.9g sodium chloride is added in appropriate water for injection, heated and boiled, is cooled to 80 ℃ to add Margarita liquid 10mL, and limit edged is cooled to 60 ℃, mixes, standby; 2. get 1.0g Borneolum Syntheticum, 0.5g ethyl hydroxybenzoate is dissolved in 3ml butanediol, adds while stirring step 1. in solution; 3. 2g hyaluronic acid sodium is dissolved in to 2. mixing and stirring in solution of step, regulates pH to 6.5, inject and be diluted with water to 1000mL, 0.22 μ m filter membrane filters, subpackage and get final product.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (5)
1. a ZHENZHU MINGMU DIYANYE, is characterized in that the prescription of said preparation is: every 1000mL specifically consists of:
Margarita liquid 10mL,
Borneolum Syntheticum 1.0g,
Ethyl hydroxybenzoate 0.5g,
Hyaluronic acid sodium 2g,
Butanediol 3-6mL,
Sodium chloride 8.9g,
All the other are water for injection.
2. a kind of pearl eye drops for improving eyesight according to claim 1, is characterized in that the prescription of said preparation is: every 1000mL specifically consists of:
Margarita liquid 10mL,
Borneolum Syntheticum 1.0g,
Ethyl hydroxybenzoate 0.5g,
Hyaluronic acid sodium 2g,
Butanediol 5mL,
Sodium chloride 8.9g,
All the other are water for injection.
3. a kind of ZHENZHU MINGMU DIYANYE according to claim 1 and 2, it is characterized in that described Margarita liquid is that Margarita powder is added in the injection water of 8 times of amounts, through 98 ℃ of heating hydrolysis, while supersound process 10min, intermittently operated three times, insulation 2h, then the sheet frame filter through 0.45 μ m microporous filter membrane filters to obtain Margarita liquid, and described Margarita liquid total protein content is greater than 2.0mg/ml.
4. a kind of ZHENZHU MINGMU DIYANYE according to claim 1 and 2, is characterized in that described Margarita liquid protein content is 2.0mg/ml～2.2mg/ml.
5. a kind of ZHENZHU MINGMU DIYANYE according to claim 1 and 2, is characterized in that its preparation method is prepared according to the following steps:
1) sodium chloride is added in appropriate water for injection, heated and boiled, is cooled to 80 ℃ to add Margarita liquid, and limit edged is cooled to 60 ℃, mixes, standby;
2) Borneolum Syntheticum, ethyl hydroxybenzoate are dissolved in to butanediol, add while stirring step 1) in solution, add water and stir 45min;
3) hyaluronic acid sodium is added to step 2) in solution, it is dissolved completely, regulate pH to 5.5～7.5, filter, filling jetting is to 1000ml.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310404998.7A CN103623003B (en) | 2013-09-09 | 2013-09-09 | A kind of ZHENZHU MINGMU DIYANYE and preparation method thereof |
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| CN103623003A true CN103623003A (en) | 2014-03-12 |
| CN103623003B CN103623003B (en) | 2016-03-23 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769920A (en) * | 2014-12-25 | 2016-07-20 | 苏州太湖美药业有限公司 | Pearl clear-sighted eye drops and preparation method |
| CN108066282A (en) * | 2018-01-17 | 2018-05-25 | 中山万汉制药有限公司 | A kind of Levofloxacin Eye drop and preparation method thereof |
| CN108158983A (en) * | 2018-01-17 | 2018-06-15 | 中山万汉制药有限公司 | A kind of sodium hyaluronate eye drops and preparation method thereof |
| CN113925828A (en) * | 2021-09-23 | 2022-01-14 | 重庆视健眼健康产业有限公司 | Borneol eye lotion |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634149A (en) * | 2004-09-28 | 2005-07-06 | 苏州工业园区天龙制药有限公司 | Pearl eye drops for improving eyesight and preparation method thereof |
| CN101455683A (en) * | 2009-01-06 | 2009-06-17 | 河北科技大学 | Pearls eyesight-improving eye drops without bacteria inhibitor and preparation method thereof |
| CN102526112A (en) * | 2012-02-20 | 2012-07-04 | 苏州工业园区天龙制药有限公司 | Sustained-release pearl clear-sighted eye drops and preparation method thereof |
-
2013
- 2013-09-09 CN CN201310404998.7A patent/CN103623003B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634149A (en) * | 2004-09-28 | 2005-07-06 | 苏州工业园区天龙制药有限公司 | Pearl eye drops for improving eyesight and preparation method thereof |
| CN101455683A (en) * | 2009-01-06 | 2009-06-17 | 河北科技大学 | Pearls eyesight-improving eye drops without bacteria inhibitor and preparation method thereof |
| CN102526112A (en) * | 2012-02-20 | 2012-07-04 | 苏州工业园区天龙制药有限公司 | Sustained-release pearl clear-sighted eye drops and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769920A (en) * | 2014-12-25 | 2016-07-20 | 苏州太湖美药业有限公司 | Pearl clear-sighted eye drops and preparation method |
| CN108066282A (en) * | 2018-01-17 | 2018-05-25 | 中山万汉制药有限公司 | A kind of Levofloxacin Eye drop and preparation method thereof |
| CN108158983A (en) * | 2018-01-17 | 2018-06-15 | 中山万汉制药有限公司 | A kind of sodium hyaluronate eye drops and preparation method thereof |
| CN108158983B (en) * | 2018-01-17 | 2018-10-19 | 中山万汉制药有限公司 | A kind of sodium hyaluronate eye drops and preparation method thereof |
| CN108066282B (en) * | 2018-01-17 | 2018-11-23 | 中山万汉制药有限公司 | A kind of Levofloxacin Eye drop and preparation method thereof |
| CN113925828A (en) * | 2021-09-23 | 2022-01-14 | 重庆视健眼健康产业有限公司 | Borneol eye lotion |
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| CN103623003B (en) | 2016-03-23 |
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Address after: 215000 Dongyan Road, Loufeng East District, Suzhou Industrial Park, Jiangsu Province Patentee after: Suzhou Lezhu Pharmaceutical Co.,Ltd. Country or region after: China Address before: 215000 Dongyan Road, Loufeng East District, Suzhou Industrial Park, Jiangsu Province Patentee before: SUZHOU INDUSTRIAL PARK TIAN LONG MEDICAL Co.,Ltd. Country or region before: China |
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