CN105125639A - Traditional Chinese medicine composition for preventing and treating mastitis of dairy cattle - Google Patents
Traditional Chinese medicine composition for preventing and treating mastitis of dairy cattle Download PDFInfo
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- CN105125639A CN105125639A CN201510595512.1A CN201510595512A CN105125639A CN 105125639 A CN105125639 A CN 105125639A CN 201510595512 A CN201510595512 A CN 201510595512A CN 105125639 A CN105125639 A CN 105125639A
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- 239000000203 mixture Substances 0.000 title claims abstract description 37
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- 241000283690 Bos taurus Species 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 claims abstract description 18
- 238000002360 preparation method Methods 0.000 claims abstract description 18
- 241000576418 Jasminum nudiflorum Species 0.000 claims abstract description 3
- 238000011282 treatment Methods 0.000 claims description 12
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- 241000628997 Flos Species 0.000 claims description 2
- 241000207840 Jasminum Species 0.000 claims description 2
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides traditional Chinese medicine composition for preventing and treating mastitis of dairy cattle. The traditional Chinese medicine composition is prepared from raw materials in parts by weight as follows: 2 parts of Jasminum nudiflorum Lindl, 2 parts of humulus japonicus and 1 part of szechuan lovage rhizomes. The invention further provides a preparation method and an application of the traditional Chinese medicine composition. Compared with antibiotic drugs commonly used clinically, the traditional Chinese medicine composition has a remarkable therapy effect, is efficient, low in price, simple and convenient to take and safe when used by veterinarians for treating mastitis of dairy cattle clinically and has a wide market prospect, and the effective rate reaches 94%.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition preventing and treating mammitis of cow and its production and use, belong to drug world.
Background technology
Mammitis of cow is a kind of multifactor property disease, namely cow mammary gland is subject to the inflammation of the cow breasts caused by factor stimulation such as physics, chemistry, microorganism, main manifestations is that milk generation physicochemical property and bacteriology change, mammary gland tissue generation Pathologic changes, be the most common in Cow product, the most difficult control, cost at most, have a strong impact on one of disease of dairy development.Mammitis of cow can be divided into clinic mastitis and latent mammitis according to breast and milk with or without clinical visible change.The mammitis of cow sickness rate of China is very high, clinic mastitis sickness rate average out to 33.4l%, and the average positive rate of latent mammitis is 73.91%, and newborn room prevalence is 44.74%.Mammitis of cow causes medical expense increase, milk yield declines, milch cow is eliminated too early, loses huge.
The early stage treatment to mammitis of cow, mainly uses antibiotics both at home and abroad.Due to the problems such as antibiotic remains and bacterial drug resistance, noresidue treatment by Chinese herbs mammitis of cow is selected day by day to come into one's own at home.Chinese medicine derives from animal, plant or mineral, pathogenic bacterium are not easily made to produce drug resistance, internal metabolism is very fast, high-efficiency low-toxicity noresidue, does not affect the edible of milk at treatments period, has medicine and nutrient double effects concurrently, both can bacteriostasis and sterilization, strengthen animal body immunologic function, can be used as again Specialty bio active additive, regulate the metabolism of body, promote the absorption of nutrient substance.
The herbal species being used for the treatment of mammitis of cow at present is clinically various, and medicine prescription is wide in range, on the high side.Therefore active research exploitation can treat efficient, inexpensive, convenient, the safety of mammitis of cow, the medicine of noresidue has very important significance.
Summary of the invention
The invention provides a kind of Chinese medicine composition preventing and treating mammitis of cow, it is prepared from by the crude drug of following weight proportioning:
Folium Jasmini Nudiflori 0.1-40 part, Herba humuli scandentis 0.1-40 part, Rhizoma Chuanxiong 0.05-20 part.
Preferably, described Chinese medicine composition is prepared from by the crude drug of following weight proportioning:
Folium Jasmini Nudiflori 1-4 part, Herba humuli scandentis 1-4 part, Rhizoma Chuanxiong 0.5-2 part.
Further preferably, described Chinese medicine composition is prepared from by the crude drug of following weight proportioning:
Folium Jasmini Nudiflori 2 parts, Herba humuli scandentis 2 parts, Rhizoma Chuanxiong 1 part.
Wherein, described Folium Jasmini Nudiflori is the blade of Oleaceae jasminum machaka flower plant Flos Jasmini Nudiflori (Jasminumnudiflorum).
Wherein, described Chinese medicine composition is by the protogenic medicinal powder of Folium Jasmini Nudiflori, Herba humuli scandentis, Rhizoma Chuanxiong, water or extractive with organic solvent, adds the pharmaceutically conventional preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
Wherein, described preparation is decoct, powder, granule, unguentum, microcapsule, filling agent, liniment, transdermal agent or injection.
The invention provides the method preparing described Chinese medicine composition, step is: the crude drug taking prescription amount, directly beat powder or water or organic solvent extraction, extracting liquid filtering, concentrated, add pharmaceutically acceptable adjuvant or complementary composition is prepared into pharmaceutically conventional preparation.
Preferably, the preparation method of described Chinese medicine composition comprises the steps:
A. take the crude drug of prescription amount, add the water of 30 times amount, decoct 2 times, each 2h, filter, filtrate concentrates, and obtains extract;
B. add ethanol in the extract of step a, staticly settle, filter, filtrate concentrates, and to obtain final product.
Present invention also offers the purposes of described Chinese medicine composition in the medicine of preparation treatment mammitis of cow.
Chinese medicine composition of the present invention is made up of according to specific proportioning Folium Jasmini Nudiflori, Herba humuli scandentis, Rhizoma Chuanxiong.Folium Jasmini Nudiflori in side: bitter, puckery, flat, promoting blood circulation and detoxication, reducing swelling and alleviating pain, for toxic swelling malignant boil, traumatic injury, wound hemorrhage; Herba humuli scandentis: property sweetness and bitterness is trembled with fear, heat-clearing and toxic substances removing, inducing diuresis to remove edema, takes orally and can control pyelonephritis etc.; External can control carbuncle furuncle and phyma poison, eczema etc.; Rhizoma Chuanxiong: acrid in the mouth, warm in nature, enter liver, gallbladder meridian, for activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain, all medicines share, and gather anti-inflammatory analgetic altogether, and blood circulation promoting and blood stasis dispelling, the effect of dispersing swelling and dissipating binds, effectively can treat mammitis of cow.
Detailed description of the invention is by the following examples described in further detail foregoing of the present invention again.But this should be interpreted as that the above-mentioned subject area of the present invention is only limitted to following instance.Under the prerequisite not departing from the above-mentioned technological thought of the present invention, the various replacement made according to ordinary skill knowledge and customary means or change, all should comprise within the scope of the invention.
Detailed description of the invention
The preparation of embodiment 1 Chinese medicine composition filling agent of the present invention
Raw material is taken by following proportioning:
Folium Jasmini Nudiflori 2g, Herba humuli scandentis 2g, Rhizoma Chuanxiong 1g
Preparation method is as follows:
A. take the crude drug of prescription amount, add the water of 30 times amount, decoct 2 times, each 2h, filter, filtrate being concentrated into is equivalent to crude drug in whole 1g/ml;
B. adding ethanol makes the whole content of ethanol be 70%, filtering-depositing, and filtrate concentrates;
C. in concentrated solution, add purified water be respectively adjusted to every mL filling agent and be equivalent to 1g primary crude drug, add the sodium benzoate of 0.3%, stir, filter, fill, gets product.
The preparation of embodiment 2 Chinese medicine composition of the present invention
Raw material is taken by following proportioning:
Folium Jasmini Nudiflori 0.1kg, Herba humuli scandentis 0.1kg, Rhizoma Chuanxiong 0.05kg
Preparation method is as follows:
Take the crude drug of prescription amount, directly beat powder or water or organic solvent extraction, extracting liquid filtering, concentrated, add pharmaceutically acceptable adjuvant or complementary composition is prepared into pharmaceutically conventional preparation.
The preparation of embodiment 3 Chinese medicine composition of the present invention
Raw material is taken by following proportioning:
Folium Jasmini Nudiflori 40g, Herba humuli scandentis 40g, Rhizoma Chuanxiong 20g
Preparation method is as follows:
Take the crude drug of prescription amount, directly beat powder or water or organic solvent extraction, extracting liquid filtering, concentrated, add pharmaceutically acceptable adjuvant or complementary composition is prepared into pharmaceutically conventional preparation.
Beneficial effect of the present invention is proved below by way of specific experiment.
1. the experimental technique of experimental example 1 Chinese medicine composition control of the present invention mammitis of cow:
1.1 laboratory sample
According to Chinese medicine composition filling agent prepared by embodiment 1
1.2 animal grouping and administrations
Select to suffer from mastitis milch cow 50, be divided into 2 groups at random, wherein I group is penicillin sodium therapeutic test group, and II group is Chinese medicine composition infusion liquid therapeutic test group.I group: intramuscular injection penicillin sodium, 2 ~ 30,000 units/kg, every day 2 times, the course for the treatment of 3-7 days; II group: by every cow head every newborn room perfusion 10ml, administration every day 2 times, the course for the treatment of 3-7 days.
1.3 mammitis of cow diagnostic criterias
The selection of clinic mastitis milch cow possess following symptom or partial symptoms person diagnosable be clinic mastitis: a. breast volume increases, heating, quality are hardening; B. skin of breast is rubescent, and palpation has pain; C. Ge Ru district is not of uniform size, supramammary lymph node enlargement; D. milk variable color, thickness, occur that floccule, ziega, clot etc. are abnormal.
1.4 mammitis of cow the standard of curative effect evaluations
Cure: clinical symptom disappearance, milk directly perceived is without exception, and milk yield recovers substantially, and SMT method testing result is healing lower than " ++ ".
Take a turn for the better: clinical symptom relief or disappearance.Have a small amount of floccule in milk, but milk color and luster is without exception.Output fails to recover normal, and SMT method testing result is still higher than " ++ ".
Invalid: each clinical symptoms in criterion does not alleviate or aggravates.
Effective percentage: effective percentage=(recovery from illness+effective)/total case load × 100%.
2. experimental result, in table 1.
The each test group of table 1 is to the Clinical Treatment Test result of mammitis of cow
3. experiment conclusion:
Result shows: Chinese medicine composition of the present invention is than penicillin sodium more remarkable treatment effect, and total cure rate and the effective percentage for the treatment of mammitis of cow are higher, and effective percentage reaches 94%.Chinese medicine composition of the present invention is the medicine that veterinary clinic treatment mammitis of cow provides a kind of efficient, inexpensive, easy, safety, noresidue, has wide market prospect.
Claims (9)
1. prevent and treat a Chinese medicine composition for mammitis of cow, it is characterized in that: it is prepared from by the crude drug of following weight proportioning:
Folium Jasmini Nudiflori 0.1-40 part, Herba humuli scandentis 0.1-40 part, Rhizoma Chuanxiong 0.05-20 part.
2. Chinese medicine composition according to claim 1, is characterized in that: it is prepared from by the crude drug of following weight proportioning:
Folium Jasmini Nudiflori 1-4 part, Herba humuli scandentis 1-4 part, Rhizoma Chuanxiong 0.5-2 part.
3. Chinese medicine composition according to claim 2, is characterized in that: it is prepared from by the crude drug of following weight proportioning:
Folium Jasmini Nudiflori 2 parts, Herba humuli scandentis 2 parts, Rhizoma Chuanxiong 1 part.
4. the Chinese medicine composition according to claim 1-3 any one, is characterized in that: described Folium Jasmini Nudiflori is the blade of Oleaceae jasminum machaka flower plant Flos Jasmini Nudiflori (Jasminumnudiflorum).
5. the Chinese medicine composition according to claim 1-4 any one, it is characterized in that: it is by the protogenic medicinal powder of Folium Jasmini Nudiflori, Herba humuli scandentis, Rhizoma Chuanxiong, water or extractive with organic solvent, add the pharmaceutically conventional preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
6. Chinese medicine composition according to claim 5, is characterized in that: described preparation is decoct, powder, granule, unguentum, microcapsule, filling agent, liniment, transdermal agent or injection.
7. prepare the method for the Chinese medicine composition described in claim 1-6 any one, it is characterized in that:
Take the crude drug of prescription amount, directly beat powder or water or organic solvent extraction, extracting liquid filtering, concentrated, add pharmaceutically acceptable adjuvant or complementary composition is prepared into pharmaceutically conventional preparation.
8. method according to claim 7, is characterized in that: it comprises the steps:
A. take the crude drug of prescription amount, add the water of 30 times amount, decoct 2 times, each 2h, filter, filtrate concentrates, and obtains extract;
B. add ethanol in the extract of step a, staticly settle, filter, filtrate concentrates, and to obtain final product.
9. the purposes of the Chinese medicine composition described in claim 1-6 any one in the medicine of preparation treatment mammitis of cow.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510595512.1A CN105125639A (en) | 2015-09-17 | 2015-09-17 | Traditional Chinese medicine composition for preventing and treating mastitis of dairy cattle |
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| CN201510595512.1A CN105125639A (en) | 2015-09-17 | 2015-09-17 | Traditional Chinese medicine composition for preventing and treating mastitis of dairy cattle |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106344724A (en) * | 2016-10-27 | 2017-01-25 | 成都乾坤动物药业股份有限公司 | Traditional Chinese veterinary drug for treating mastitis of dairy cows and application |
| CN106511445A (en) * | 2016-12-30 | 2017-03-22 | 成都乾坤动物药业股份有限公司 | Application of pithecellobium clypearia or extract to preparation of drugs for treating cow mastitis |
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| CN102178087A (en) * | 2011-04-18 | 2011-09-14 | 郑州牧业工程高等专科学校 | Chinese herb galactagogue for cows during the middle period of milk production |
| CN103168937A (en) * | 2011-12-22 | 2013-06-26 | 郑州牧业工程高等专科学校 | Additive mainly prepared from Chinese herbal medicines and specially used in high productive dairy cow peak period |
| WO2014017360A1 (en) * | 2012-07-25 | 2014-01-30 | 株式会社トクヤマデンタル | Hardening paste and kit for preparing alginate curable composition |
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2015
- 2015-09-17 CN CN201510595512.1A patent/CN105125639A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102178087A (en) * | 2011-04-18 | 2011-09-14 | 郑州牧业工程高等专科学校 | Chinese herb galactagogue for cows during the middle period of milk production |
| CN103168937A (en) * | 2011-12-22 | 2013-06-26 | 郑州牧业工程高等专科学校 | Additive mainly prepared from Chinese herbal medicines and specially used in high productive dairy cow peak period |
| WO2014017360A1 (en) * | 2012-07-25 | 2014-01-30 | 株式会社トクヤマデンタル | Hardening paste and kit for preparing alginate curable composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106344724A (en) * | 2016-10-27 | 2017-01-25 | 成都乾坤动物药业股份有限公司 | Traditional Chinese veterinary drug for treating mastitis of dairy cows and application |
| CN106511445A (en) * | 2016-12-30 | 2017-03-22 | 成都乾坤动物药业股份有限公司 | Application of pithecellobium clypearia or extract to preparation of drugs for treating cow mastitis |
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