CN103622782B - Biological film wound protecting system - Google Patents
Biological film wound protecting system Download PDFInfo
- Publication number
- CN103622782B CN103622782B CN201310079746.1A CN201310079746A CN103622782B CN 103622782 B CN103622782 B CN 103622782B CN 201310079746 A CN201310079746 A CN 201310079746A CN 103622782 B CN103622782 B CN 103622782B
- Authority
- CN
- China
- Prior art keywords
- biological film
- xenogenesis
- cell biological
- active carbon
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 31
- 229920002635 polyurethane Polymers 0.000 claims abstract description 14
- 239000004814 polyurethane Substances 0.000 claims abstract description 14
- 229910052799 carbon Inorganic materials 0.000 claims description 29
- 230000000845 anti-microbial effect Effects 0.000 claims description 27
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 9
- 229910003460 diamond Inorganic materials 0.000 claims description 8
- 239000010432 diamond Substances 0.000 claims description 8
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 6
- 239000003381 stabilizer Substances 0.000 claims description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 3
- -1 alkyl dimethyls ammonium salt Chemical class 0.000 claims description 3
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 claims description 3
- 239000002280 amphoteric surfactant Substances 0.000 claims description 3
- 229960003237 betaine Drugs 0.000 claims description 3
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 abstract description 6
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 2
- 230000035876 healing Effects 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 25
- 208000027418 Wounds and injury Diseases 0.000 description 25
- 238000000034 method Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a biological film wound protecting system which comprises a heterogeneous decellularized biological film or a heterogeneous decellularized biological film containing antibiotic constituents. The outer surface of the heterogeneous decellularized biological film or the outer surface of the heterogeneous decellularized biological film containing the antibiotic constituents is coated with polyurethane and/or medical activated carbon function dressing. A wound surface negative pressure drainage mechanism used for conducting negative pressure drainage on a wound surface is arranged outside the polyurethane and/or the medical activated carbon function dressing. The biological film wound protecting system can be effectively used for protecting various wound surfaces caused by burning, traumatism, operations, infection and the like, wound surface infection is controlled, a negative pressure drainage system is additionally arranged, and healing of the wound surfaces is facilitated. The biological film wound protecting system is tested by more than 100 clinical cases and the effective rate is over 95%.
Description
Technical field
The present invention relates to a kind of biomembrane and protect wound system.
Background technology
The wound surface that existing reason such as protection burn, wound, operation, infection etc. causes protect wound, often adopt various different treatment means and product, but existing method and product are often unsatisfactory in result of use.
Summary of the invention
The object of the present invention is to provide a kind of rational in infrastructure, the biomembrane that the various wound surface performances that the reasons such as protection burn, wound, operation, infection cause are good takes off cell and protects wound system.
Technical solution of the present invention is:
A kind of biomembrane protects wound system, it is characterized in that: comprise xenogenesis and take off cell biological film or take off cell biological film containing the xenogenesis of antimicrobial component, take off cell biological film at xenogenesis or take off cell biological film outer surface containing the xenogenesis of antimicrobial component and cover polyurethane and/or medicinal active carbon functional dressings, the Wound-surface negative pressure drainage mechanism of wound surface being carried out to negative pressure drainage is set outside polyurethane and/or medicinal active carbon functional dressings.
Take off cell biological film at xenogenesis or take off cell biological film outer surface containing the xenogenesis of antimicrobial component and cover polyurethane and medicinal active carbon functional dressings, and polyurethane is positioned at the outside of medicinal active carbon functional dressings.
Described xenogenesis takes off cell biological film or takes off cell biological film containing the xenogenesis of antimicrobial component is mesh, namely take off cell biological film at xenogenesis or take off on cell biological film containing the xenogenesis of antimicrobial component and equally distributed mesh is set, mesh is in its natural state in gap form, and assume diamond in shape well format in a stretched state; Or xenogenesis takes off cell biological film or takes off cell biological film containing the xenogenesis of antimicrobial component be circular hole, the xenogenesis namely taking off cell biological film at xenogenesis or contain antimicrobial component takes off on cell biological film and arranges equally distributed circular hole, and circular hole presents in its natural state.
Described medicinal active carbon functional dressings is mesh, namely on medicinal active carbon functional dressings, arranges equally distributed mesh, and mesh is in its natural state in gap form, and assume diamond in shape well format in a stretched state; Or medicinal active carbon functional dressings is circular hole, namely equally distributed circular hole is set on medicinal active carbon functional dressings, and circular hole presents in its natural state.
The preparation method that the described xenogenesis containing antimicrobial component takes off cell biological film is: xenogenesis is taken off cell biological film and be soaked in silver ion solution or liquor hibitane; In described silver ion solution, silver nitrate mass concentration is 0.01 ~ 1%, and stabilizing agent mass concentration is 0.01 ~ 1%, and stabilizing agent is alkyl trimethyl ammonium salt, many alkyl dimethyls ammonium salt or betaine type amphoteric surfactant; In liquor hibitane, hibitane mass concentration is 0.1% ~ 5%.
The present invention can be effective to the various wound surface protecting the reasons such as burn, wound, operation, infection to cause, and controls traumatic infection, increases drainage system, wound healing.Through 100 many cases clinical case checkings, effective percentage reaches more than 95%.
Below in conjunction with embodiment, the invention will be further described.
Detailed description of the invention
Embodiment 1:
A kind of biomembrane takes off cell and protects wound system, comprise xenogenesis and take off cell biological film (preparation method that xenogenesis takes off cell biological film is shown in Chinese patent CN102580140A), take off cell biological film outer surface at xenogenesis and cover medicinal active carbon functional dressings, the Wound-surface negative pressure drainage mechanism (Wound-surface negative pressure drainage mechanism adopts commercially available prod, is made up of drainage tube, medical pad pasting, non-return folder, three-way straight pipe, connection tube) of wound surface being carried out to negative pressure drainage is set outside medicinal active carbon functional dressings.
It is mesh that described xenogenesis takes off cell biological film, namely takes off on cell biological film at xenogenesis and arranges equally distributed mesh, and mesh is in its natural state in gap form, and assume diamond in shape well format in a stretched state; Or it is circular hole that xenogenesis takes off cell biological film, namely take off on cell biological film at xenogenesis and equally distributed circular hole is set, and circular hole presents in its natural state.
Described medicinal active carbon functional dressings is mesh, namely on medicinal active carbon functional dressings, arranges equally distributed mesh, and mesh is in its natural state in gap form, and assume diamond in shape well format in a stretched state; Or medicinal active carbon functional dressings is circular hole, namely equally distributed circular hole is set on medicinal active carbon functional dressings, and circular hole presents in its natural state.
Through the checking of many cases clinical case, effective percentage reaches more than 95%.
Embodiment 2:
A kind of biomembrane takes off cell and protects wound system, the xenogenesis comprised containing antimicrobial component takes off cell biological film, take off cell biological film outer surface at the xenogenesis containing antimicrobial component and cover polyurethane, the Wound-surface negative pressure drainage mechanism (Wound-surface negative pressure drainage mechanism adopts commercially available prod, is made up of drainage tube, medical pad pasting, non-return folder, three-way straight pipe, connection tube) of wound surface being carried out to negative pressure drainage is set outside polyurethane.The preparation method that the described xenogenesis containing antimicrobial component takes off cell biological film is: xenogenesis is taken off cell biological film (preparation method that xenogenesis takes off cell biological film is shown in Chinese patent CN102580140A) and be soaked in silver ion solution or liquor hibitane; In described silver ion solution, silver nitrate mass concentration is 0.01 ~ 1%, and stabilizing agent mass concentration is 0.01 ~ 1%, and stabilizing agent is alkyl trimethyl ammonium salt (or many alkyl dimethyls ammonium salt or betaine type amphoteric surfactant); In liquor hibitane, hibitane mass concentration is 0.1% ~ 5%.
It is mesh that the described xenogenesis containing antimicrobial component takes off cell biological film, and namely take off on cell biological film at the xenogenesis containing antimicrobial component and arrange equally distributed mesh, mesh is in its natural state in gap form, and assume diamond in shape well format in a stretched state; Or it is circular hole that the xenogenesis containing antimicrobial component takes off cell biological film, namely take off on cell biological film at the xenogenesis containing antimicrobial component and equally distributed circular hole is set, and circular hole presents in its natural state.
Described medicinal active carbon functional dressings is mesh, namely on medicinal active carbon functional dressings, arranges equally distributed mesh, and mesh is in its natural state in gap form, and assume diamond in shape well format in a stretched state; Or medicinal active carbon functional dressings is circular hole, namely equally distributed circular hole is set on medicinal active carbon functional dressings, and circular hole presents in its natural state.
Through the checking of many cases clinical case, effective percentage reaches more than 95%.
Embodiment 3:
A kind of biomembrane takes off cell and protects wound system, the xenogenesis comprised containing antimicrobial component takes off cell biological film, take off cell biological film outer surface at the xenogenesis containing antimicrobial component and cover medicinal active carbon functional dressings, polyurethane is covered at medicinal active carbon functional dressings outer surface, the Wound-surface negative pressure drainage mechanism (Wound-surface negative pressure drainage mechanism adopts commercially available prod, is made up of drainage tube, medical pad pasting, non-return folder, three-way straight pipe, connection tube) of wound surface being carried out to negative pressure drainage is set outside polyurethane.
Xenogenesis containing antimicrobial component takes off the preparation of cell biological film with embodiment 2; Medicinal active carbon functional dressings, take off the version of cell biological film containing the xenogenesis of antimicrobial component with embodiment 2.
Through the checking of many cases clinical case, effective percentage reaches more than 95%.
Claims (3)
1. a biomembrane protects wound system, it is characterized in that: comprise xenogenesis and take off cell biological film or take off cell biological film containing the xenogenesis of antimicrobial component, take off cell biological film at xenogenesis or take off cell biological film outer surface containing the xenogenesis of antimicrobial component and cover polyurethane and/or medicinal active carbon functional dressings, the Wound-surface negative pressure drainage mechanism of wound surface being carried out to negative pressure drainage is set outside polyurethane and/or medicinal active carbon functional dressings; Described xenogenesis takes off cell biological film or takes off cell biological film containing the xenogenesis of antimicrobial component is mesh, namely take off cell biological film at xenogenesis or take off on cell biological film containing the xenogenesis of antimicrobial component and equally distributed mesh is set, mesh is in its natural state in gap form, and assume diamond in shape well format in a stretched state; Or xenogenesis takes off cell biological film or takes off cell biological film containing the xenogenesis of antimicrobial component be circular hole, the xenogenesis namely taking off cell biological film at xenogenesis or contain antimicrobial component takes off on cell biological film and arranges equally distributed circular hole, and circular hole presents in its natural state; Described medicinal active carbon functional dressings is mesh, namely on medicinal active carbon functional dressings, arranges equally distributed mesh, and mesh is in its natural state in gap form, and assume diamond in shape well format in a stretched state; Or medicinal active carbon functional dressings is circular hole, namely equally distributed circular hole is set on medicinal active carbon functional dressings, and circular hole presents in its natural state.
2. biomembrane according to claim 1 protects wound system, it is characterized in that: take off cell biological film at xenogenesis or take off cell biological film outer surface covering polyurethane and medicinal active carbon functional dressings containing the xenogenesis of antimicrobial component, and polyurethane is positioned at the outside of medicinal active carbon functional dressings.
3. biomembrane according to claim 1 and 2 protects wound system, it is characterized in that: the preparation method that the described xenogenesis containing antimicrobial component takes off cell biological film is: xenogenesis is taken off cell biological film and be soaked in silver ion solution or liquor hibitane; In described silver ion solution, silver nitrate mass concentration is 0.01 ~ 1%, and stabilizing agent mass concentration is 0.01 ~ 1%, and stabilizing agent is alkyl trimethyl ammonium salt, many alkyl dimethyls ammonium salt or betaine type amphoteric surfactant; In liquor hibitane, hibitane mass concentration is 0.1% ~ 5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310079746.1A CN103622782B (en) | 2013-03-13 | 2013-03-13 | Biological film wound protecting system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310079746.1A CN103622782B (en) | 2013-03-13 | 2013-03-13 | Biological film wound protecting system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103622782A CN103622782A (en) | 2014-03-12 |
| CN103622782B true CN103622782B (en) | 2015-01-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310079746.1A Active CN103622782B (en) | 2013-03-13 | 2013-03-13 | Biological film wound protecting system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103622782B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016022441A1 (en) * | 2014-08-08 | 2016-02-11 | Innovation Technologies, Inc. | Materials and methods for controlling infections with negative pressure wound therapy |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201085737Y (en) * | 2007-09-14 | 2008-07-16 | 中国人民解放军军事医学科学院卫生装备研究所 | Three-protective dressing for first aid |
| CN101390790A (en) * | 2008-10-27 | 2009-03-25 | 西安交通大学医学院第一附属医院 | A kind of airtight trauma wound treatment dressing system |
| CN102781485A (en) * | 2009-10-07 | 2012-11-14 | 克雷西斯公司 | A scaffold material for wound care and/or other tissue healing applications |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8632512B2 (en) * | 2010-04-09 | 2014-01-21 | Kci Licensing, Inc. | Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds |
-
2013
- 2013-03-13 CN CN201310079746.1A patent/CN103622782B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201085737Y (en) * | 2007-09-14 | 2008-07-16 | 中国人民解放军军事医学科学院卫生装备研究所 | Three-protective dressing for first aid |
| CN101390790A (en) * | 2008-10-27 | 2009-03-25 | 西安交通大学医学院第一附属医院 | A kind of airtight trauma wound treatment dressing system |
| CN102781485A (en) * | 2009-10-07 | 2012-11-14 | 克雷西斯公司 | A scaffold material for wound care and/or other tissue healing applications |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103622782A (en) | 2014-03-12 |
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| C14 | Grant of patent or utility model | ||
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