CN103156730A - Heterogeneity decellularized cell dermis matrix wound protecting system - Google Patents
Heterogeneity decellularized cell dermis matrix wound protecting system Download PDFInfo
- Publication number
- CN103156730A CN103156730A CN2013100796844A CN201310079684A CN103156730A CN 103156730 A CN103156730 A CN 103156730A CN 2013100796844 A CN2013100796844 A CN 2013100796844A CN 201310079684 A CN201310079684 A CN 201310079684A CN 103156730 A CN103156730 A CN 103156730A
- Authority
- CN
- China
- Prior art keywords
- dermal matrix
- acellular dermal
- xenogenic acellular
- xenogenic
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011159 matrix material Substances 0.000 title claims abstract description 71
- 210000004207 dermis Anatomy 0.000 title abstract 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000004814 polyurethane Substances 0.000 claims abstract description 14
- 229920002635 polyurethane Polymers 0.000 claims abstract description 14
- 230000002500 effect on skin Effects 0.000 claims description 64
- 229910052799 carbon Inorganic materials 0.000 claims description 29
- 230000000845 anti-microbial effect Effects 0.000 claims description 27
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 9
- 229910003460 diamond Inorganic materials 0.000 claims description 8
- 239000010432 diamond Substances 0.000 claims description 8
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 6
- 239000003381 stabilizer Substances 0.000 claims description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 3
- -1 alkyl dimethyls ammonium salt Chemical class 0.000 claims description 3
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 claims description 3
- 239000002280 amphoteric surfactant Substances 0.000 claims description 3
- 229960003237 betaine Drugs 0.000 claims description 3
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 3
- 206010052428 Wound Diseases 0.000 abstract description 32
- 208000027418 Wounds and injury Diseases 0.000 abstract description 32
- 208000015181 infectious disease Diseases 0.000 abstract description 6
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 208000014674 injury Diseases 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a heterogeneity decellularized cell dermis matrix wound protecting system which comprises a heterogeneity decellularized cell dermis matrix (ADM) or heterogeneity decellularized cell dermis matrix containing antibiotic constituents. Polyurethane and/or medical activated carbon functional dressing materials are coated on an outer surface of heterogeneity decellularized cell dermis matrix or the heterogeneity decellularized cell dermis matrix containing antibiotic constituents. A wound surface negative pressure drainage mechanism which can be in negative pressure drainage for a wound surface is arranged outside of the polyurethane and/or the medical activated carbon functional dressing materials. The heterogeneity decellularized cell dermis matrix wound protecting system can be effectively used for protecting various wound surfaces brought from causes of burns, traumas, surgeries, infections and the like. Infections of the wound surfaces can be controlled, negative pressure drainage systems can be added to promote the curing of the wound surfaces. Through more one hundred of clinical cases testified, effective rates can reach to more than 95%.
Description
Technical field
The present invention relates to a kind of Xenogenic acellular dermal matrix and protect the wound system.
Background technology
The wound surface that the reasons such as existing protection burn, wound, operation, infection cause protect wound, often adopt various treatment means and product, but existing method and product are often unsatisfactory on result of use.
Summary of the invention
The object of the present invention is to provide a kind of rational in infrastructurely, the good Xenogenic acellular dermal matrix of various wound surface performances that the reasons such as protection burn, wound, operation, infection cause protects the wound system.
Technical solution of the present invention is:
A kind of Xenogenic acellular dermal matrix protects the wound system, it is characterized in that: comprise Xenogenic acellular dermal matrix (ADM) or contain the Xenogenic acellular dermal matrix of antimicrobial component, cover polyurethane and/or medicinal active carbon functional dressings at Xenogenic acellular dermal matrix or the Xenogenic acellular dermal matrix outer surface that contains antimicrobial component, the Wound-surface negative pressure drain mechanism that wound surface is carried out negative pressure drainage is set outside polyurethane and/or medicinal active carbon functional dressings.
Cover polyurethane and medicinal active carbon functional dressings at Xenogenic acellular dermal matrix or the Xenogenic acellular dermal matrix outer surface that contains antimicrobial component, and polyurethane is positioned at the outside of medicinal active carbon functional dressings.
Described Xenogenic acellular dermal matrix or the Xenogenic acellular dermal matrix that contains antimicrobial component are mesh, namely at Xenogenic acellular dermal matrix or contain on the Xenogenic acellular dermal matrix of antimicrobial component equally distributed mesh is set, mesh is the gap form under naturalness, well format assumes diamond in shape under extended state; Perhaps Xenogenic acellular dermal matrix or the Xenogenic acellular dermal matrix that contains antimicrobial component are circular hole, namely at Xenogenic acellular dermal matrix or contain on the Xenogenic acellular dermal matrix of antimicrobial component equally distributed circular hole is set, and circular hole is to present under naturalness.
Described medicinal active carbon functional dressings is mesh, namely on medicinal active carbon functional dressings, equally distributed mesh is set, and mesh is the gap form under naturalness, and well format assumes diamond in shape under extended state; Perhaps medicinal active carbon functional dressings is circular hole, namely on medicinal active carbon functional dressings, equally distributed circular hole is set, and circular hole is to present under naturalness.
The described preparation method that contains the Xenogenic acellular dermal matrix of antimicrobial component is: Xenogenic acellular dermal matrix is soaked in silver ion solution or liquor hibitane; In described silver ion solution, the silver nitrate mass concentration is 0.01 ~ 1%, and the stabilizing agent mass concentration is 0.01 ~ 1%, and stabilizing agent is alkyl trimethyl ammonium salt, many alkyl dimethyls ammonium salt or betaine type amphoteric surfactant; In liquor hibitane, the hibitane mass concentration is 0.1% ~ 5%.
The present invention can be effective to the various wound surface of protecting the reasons such as burn, wound, operation, infection to cause, controls traumatic infection, increases drainage system, wound healing.Through 100 many cases clinical case checkings, effective percentage reaches more than 95%.
The invention will be further described below in conjunction with embodiment.
The specific embodiment
Embodiment 1:
A kind of Xenogenic acellular dermal matrix protects the wound system, comprise Xenogenic acellular dermal matrix (preparation method of Xenogenic acellular dermal matrix is seen Chinese patent CN102580141A), cover medicinal active carbon functional dressings at the Xenogenic acellular dermal matrix outer surface, the Wound-surface negative pressure drain mechanism (Wound-surface negative pressure drain mechanism adopts the commercially available prod, is comprised of drainage tube, medical pad pasting, non-return folder, three-way straight pipe, connection tube) that wound surface is carried out negative pressure drainage is set outside medicinal active carbon functional dressings.
Described Xenogenic acellular dermal matrix is mesh, and equally distributed mesh namely is set on Xenogenic acellular dermal matrix, and mesh is the gap form under naturalness, and well format assumes diamond in shape under extended state; Perhaps Xenogenic acellular dermal matrix is circular hole, and equally distributed circular hole namely is set on Xenogenic acellular dermal matrix, and circular hole is to present under naturalness.
Described medicinal active carbon functional dressings is mesh, namely on medicinal active carbon functional dressings, equally distributed mesh is set, and mesh is the gap form under naturalness, and well format assumes diamond in shape under extended state; Perhaps medicinal active carbon functional dressings is circular hole, namely on medicinal active carbon functional dressings, equally distributed circular hole is set, and circular hole is to present under naturalness.
Through the checking of many cases clinical case, effective percentage reaches more than 95%.
Embodiment 2:
A kind of Xenogenic acellular dermal matrix protects the wound system, comprise the Xenogenic acellular dermal matrix that contains antimicrobial component, cover polyurethane at the Xenogenic acellular dermal matrix outer surface that contains antimicrobial component, the Wound-surface negative pressure drain mechanism (Wound-surface negative pressure drain mechanism adopts the commercially available prod, is comprised of drainage tube, medical pad pasting, non-return folder, three-way straight pipe, connection tube) that wound surface is carried out negative pressure drainage is set outside polyurethane.The described preparation method that contains the Xenogenic acellular dermal matrix of antimicrobial component is: Xenogenic acellular dermal matrix (preparation method of Xenogenic acellular dermal matrix is seen Chinese patent CN102580141A) is soaked in silver ion solution or liquor hibitane; In described silver ion solution, the silver nitrate mass concentration is 0.01 ~ 1%, and the stabilizing agent mass concentration is 0.01 ~ 1%, and stabilizing agent is alkyl trimethyl ammonium salt (or many alkyl dimethyls ammonium salt or betaine type amphoteric surfactant); In liquor hibitane, the hibitane mass concentration is 0.1% ~ 5%.
The described Xenogenic acellular dermal matrix that contains antimicrobial component is mesh, namely equally distributed mesh is set containing on the Xenogenic acellular dermal matrix of antimicrobial component, and mesh is the gap form under naturalness, and well format assumes diamond in shape under extended state; The Xenogenic acellular dermal matrix that perhaps contains antimicrobial component is circular hole, namely equally distributed circular hole is set containing on the Xenogenic acellular dermal matrix of antimicrobial component, and circular hole is to present under naturalness.
Described medicinal active carbon functional dressings is mesh, namely on medicinal active carbon functional dressings, equally distributed mesh is set, and mesh is the gap form under naturalness, and well format assumes diamond in shape under extended state; Perhaps medicinal active carbon functional dressings is circular hole, namely on medicinal active carbon functional dressings, equally distributed circular hole is set, and circular hole is to present under naturalness.
Through the checking of many cases clinical case, effective percentage reaches more than 95%.
Embodiment 3:
A kind of Xenogenic acellular dermal matrix protects the wound system, comprise the Xenogenic acellular dermal matrix that contains antimicrobial component, cover medicinal active carbon functional dressings at the Xenogenic acellular dermal matrix outer surface that contains antimicrobial component, cover polyurethane at medicinal active carbon functional dressings outer surface, the Wound-surface negative pressure drain mechanism (Wound-surface negative pressure drain mechanism adopts the commercially available prod, is comprised of drainage tube, medical pad pasting, non-return folder, three-way straight pipe, connection tube) that wound surface is carried out negative pressure drainage is set outside polyurethane.
Contain the preparation of Xenogenic acellular dermal matrix of antimicrobial component with embodiment 2; Medicinal active carbon functional dressings, contain the version of Xenogenic acellular dermal matrix of antimicrobial component with embodiment 2.
Through the checking of many cases clinical case, effective percentage reaches more than 95%.
Claims (5)
1. an Xenogenic acellular dermal matrix protects the wound system, it is characterized in that: comprise Xenogenic acellular dermal matrix or contain the Xenogenic acellular dermal matrix of antimicrobial component, cover polyurethane and/or medicinal active carbon functional dressings at Xenogenic acellular dermal matrix or the Xenogenic acellular dermal matrix outer surface that contains antimicrobial component, the Wound-surface negative pressure drain mechanism that wound surface is carried out negative pressure drainage is set outside polyurethane and/or medicinal active carbon functional dressings.
2. Xenogenic acellular dermal matrix according to claim 1 protects the wound system, it is characterized in that: cover polyurethane and medicinal active carbon functional dressings at Xenogenic acellular dermal matrix or the Xenogenic acellular dermal matrix outer surface that contains antimicrobial component, and polyurethane is positioned at the outside of medicinal active carbon functional dressings.
3. Xenogenic acellular dermal matrix according to claim 1 and 2 protects the wound system, it is characterized in that: described Xenogenic acellular dermal matrix or the Xenogenic acellular dermal matrix that contains antimicrobial component are mesh, namely at Xenogenic acellular dermal matrix or contain on the Xenogenic acellular dermal matrix of antimicrobial component equally distributed mesh is set, mesh is the gap form under naturalness, well format assumes diamond in shape under extended state; Perhaps Xenogenic acellular dermal matrix or the Xenogenic acellular dermal matrix that contains antimicrobial component are circular hole, namely at Xenogenic acellular dermal matrix or contain on the Xenogenic acellular dermal matrix of antimicrobial component equally distributed circular hole is set, and circular hole is to present under naturalness.
4. Xenogenic acellular dermal matrix according to claim 1 and 2 protects the wound system, it is characterized in that: described medicinal active carbon functional dressings is mesh, namely on medicinal active carbon functional dressings, equally distributed mesh is set, mesh is the gap form under naturalness, well format assumes diamond in shape under extended state; Perhaps medicinal active carbon functional dressings is circular hole, namely on medicinal active carbon functional dressings, equally distributed circular hole is set, and circular hole is to present under naturalness.
5. Xenogenic acellular dermal matrix according to claim 1 and 2 protects the wound system, and it is characterized in that: the described preparation method that contains the Xenogenic acellular dermal matrix of antimicrobial component is: Xenogenic acellular dermal matrix is soaked in silver ion solution or liquor hibitane; In described silver ion solution, the silver nitrate mass concentration is 0.01 ~ 1%, and the stabilizing agent mass concentration is 0.01 ~ 1%, and stabilizing agent is alkyl trimethyl ammonium salt, many alkyl dimethyls ammonium salt or betaine type amphoteric surfactant; In liquor hibitane, the hibitane mass concentration is 0.1% ~ 5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100796844A CN103156730A (en) | 2013-03-13 | 2013-03-13 | Heterogeneity decellularized cell dermis matrix wound protecting system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100796844A CN103156730A (en) | 2013-03-13 | 2013-03-13 | Heterogeneity decellularized cell dermis matrix wound protecting system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103156730A true CN103156730A (en) | 2013-06-19 |
Family
ID=48580601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013100796844A Pending CN103156730A (en) | 2013-03-13 | 2013-03-13 | Heterogeneity decellularized cell dermis matrix wound protecting system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103156730A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653814A (en) * | 2018-05-22 | 2018-10-16 | 北京清源伟业生物组织工程科技有限公司 | A kind of preparation method of Acellular cartilaginous matrix material |
| CN113144295A (en) * | 2021-04-29 | 2021-07-23 | 武汉理工大学 | Double-layer artificial dermis prepared based on extracellular matrix material and preparation method thereof |
| CN116019982A (en) * | 2023-03-13 | 2023-04-28 | 杭州华迈医疗科技有限公司 | Acellular dermal matrix, and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201085737Y (en) * | 2007-09-14 | 2008-07-16 | 中国人民解放军军事医学科学院卫生装备研究所 | Three-protective dressing for first aid |
| WO2011127188A2 (en) * | 2010-04-09 | 2011-10-13 | Kci Licensing, Inc. | Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds |
| CN102781485A (en) * | 2009-10-07 | 2012-11-14 | 克雷西斯公司 | A scaffold material for wound care and/or other tissue healing applications |
| CN203138855U (en) * | 2013-03-13 | 2013-08-21 | 潘银根 | Novel heterogeneity decellularized dermal matrix wound-protecting system |
| CN203138856U (en) * | 2013-03-13 | 2013-08-21 | 潘银根 | Novel dermal matrix wound-protecting system |
| CN203138852U (en) * | 2013-03-13 | 2013-08-21 | 潘银根 | Heterogeneous acellular dermal matrix wound protecting system |
-
2013
- 2013-03-13 CN CN2013100796844A patent/CN103156730A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201085737Y (en) * | 2007-09-14 | 2008-07-16 | 中国人民解放军军事医学科学院卫生装备研究所 | Three-protective dressing for first aid |
| CN102781485A (en) * | 2009-10-07 | 2012-11-14 | 克雷西斯公司 | A scaffold material for wound care and/or other tissue healing applications |
| WO2011127188A2 (en) * | 2010-04-09 | 2011-10-13 | Kci Licensing, Inc. | Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds |
| CN203138855U (en) * | 2013-03-13 | 2013-08-21 | 潘银根 | Novel heterogeneity decellularized dermal matrix wound-protecting system |
| CN203138856U (en) * | 2013-03-13 | 2013-08-21 | 潘银根 | Novel dermal matrix wound-protecting system |
| CN203138852U (en) * | 2013-03-13 | 2013-08-21 | 潘银根 | Heterogeneous acellular dermal matrix wound protecting system |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653814A (en) * | 2018-05-22 | 2018-10-16 | 北京清源伟业生物组织工程科技有限公司 | A kind of preparation method of Acellular cartilaginous matrix material |
| CN113144295A (en) * | 2021-04-29 | 2021-07-23 | 武汉理工大学 | Double-layer artificial dermis prepared based on extracellular matrix material and preparation method thereof |
| CN116019982A (en) * | 2023-03-13 | 2023-04-28 | 杭州华迈医疗科技有限公司 | Acellular dermal matrix, and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2441266T3 (en) | Methods for producing antimicrobial wet wound dressings attached to silver and wet wound dressings produced by such methods | |
| AU2012282287A8 (en) | Wound dressing and method of treatment | |
| ES2530417T3 (en) | Dressing device for use with a cannula or catheter | |
| WO2016113550A3 (en) | Dressing | |
| WO2007127236A3 (en) | Antimicrobial site dressings | |
| TW570815B (en) | Transdermal therapeutic system (TTS) containing the active substance fentanyl | |
| CN102850598B (en) | Alginate-gelatin-carboxymethylcellulose sodium blend membrane, and preparation and application thereof | |
| CN203953974U (en) | A kind of binder packing box | |
| WO2013070411A4 (en) | Absorbent foam tape and related methods therefor | |
| WO2010018559A3 (en) | Formulations for a two-phase management of wound healing and dressings incorporating such formulations. | |
| CN103156730A (en) | Heterogeneity decellularized cell dermis matrix wound protecting system | |
| WO2006037606A3 (en) | Wound dressing compositions, especially for delivery of protease inhibitors | |
| EP3295932A3 (en) | Stable odf composition containing hardly soluble therapeutic agent | |
| JP2012509124A5 (en) | ||
| CN203107428U (en) | Silver-plated adhesive bandage | |
| CL2008001282A1 (en) | Pharmaceutical composition with antimicrobial activity comprising a halogenated amino acid and an anti-inflammatory agent; use to prevent or treat a tissue infection, where said tissue is ocular, nasal, sinus, or dermal, or a respiratory infection. | |
| CN103622782B (en) | Biological film wound protecting system | |
| ATE482682T1 (en) | NEW BANDAGE PROTECTION | |
| CN203138856U (en) | Novel dermal matrix wound-protecting system | |
| CN203138852U (en) | Heterogeneous acellular dermal matrix wound protecting system | |
| CN203138855U (en) | Novel heterogeneity decellularized dermal matrix wound-protecting system | |
| KR102008591B1 (en) | Adhesive plaster structure for treating wounds caused by ingrown nails | |
| CN202908960U (en) | Nano-silver dressing gasket for triangular bandage first-aid packet as well as triangular bandage first-aid packet | |
| CN203138853U (en) | Wound protection system of biological membrane | |
| CN203138851U (en) | Novel biological membrane wound-protecting system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130619 |