CN103585707A - Total liquid ventilation respirator - Google Patents
Total liquid ventilation respirator Download PDFInfo
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- CN103585707A CN103585707A CN201310603469.XA CN201310603469A CN103585707A CN 103585707 A CN103585707 A CN 103585707A CN 201310603469 A CN201310603469 A CN 201310603469A CN 103585707 A CN103585707 A CN 103585707A
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- piston pump
- oxygenator
- liquid
- conduit
- expiration
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- 239000007788 liquid Substances 0.000 title claims abstract description 91
- 238000009423 ventilation Methods 0.000 title claims abstract description 23
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 10
- 239000001301 oxygen Substances 0.000 claims abstract description 10
- 238000006073 displacement reaction Methods 0.000 claims description 8
- 230000002685 pulmonary effect Effects 0.000 claims description 7
- 210000004072 lung Anatomy 0.000 abstract description 13
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract description 9
- 239000007789 gas Substances 0.000 abstract description 7
- 230000009123 feedback regulation Effects 0.000 abstract description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 8
- 230000003434 inspiratory effect Effects 0.000 description 7
- 229910002092 carbon dioxide Inorganic materials 0.000 description 4
- 239000001569 carbon dioxide Substances 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000005399 mechanical ventilation Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000002640 oxygen therapy Methods 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000002644 respiratory therapy Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
The invention relates to a total liquid ventilation respirator, and aims at providing a respirator which can accurately regulate and control respiration parameters and carry out feedback regulation. According to the technical scheme, the total liquid ventilation respirator comprises a liquid conveying channel. The liquid conveying channel comprises an oxygenator assembly, a buffer pool and a piston pump assembly. The oxygenator assembly comprises a first oxygenator and a second oxygenator, wherein the upper portion of the first oxygenator and the upper portion of the second oxygenator are communicated through a catheter, and the lower portion of the first oxygenator and the lower portion of the second oxygenator are respectively provided with a gas inlet for outside source oxygen. The upper portion of the buffer pool is communicated with the second oxygenator through a catheter. The piston pump assembly is composed of an inspiration piston pump and an expiration piston pump, wherein a liquid inlet of the inspiration piston pump is communicated with the lower end of the buffer pool through a catheter, a Y-shaped catheter is arranged between the inspiration piston pump and the expiration piston pump, a first end of the Y-shaped catheter is connected with a liquid outlet of the inspiration piston pump, a second end of the Y-shaped catheter is connected with a liquid inlet of the expiration piston pump, a third end of the Y-shaped catheter is connected with the lung of a patient, and a liquid outlet of the expiration piston pump is communicated with the first oxygenator through a catheter.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, be specifically related to a kind of total liquid ventilation respirator.
Background technology
Total liquid ventilation technology is a novel respiratory therapy technology for the treatment of acute respiratory distress syndrome, its principle is to adopt the interior gaseous state breathing medium of the completely alternative lung of liquid (perfluocarbon) oxygen and carbon dioxide to highly dissoluble, using liquid ventilator injects oxygenate liquid in lung and carries out gas exchange, again the liquid that is dissolved with a high carbon dioxide is excreted, in oxygenator, carry out the process of oxygenate and removing carbon dioxide.The multicenter randomized control clinical trial zoopery of total liquid ventilation and traditional mechanical ventilation confirms that total liquid ventilation can significantly improve body gas exchange, protection lung normal structure form, suppress pulmonary inflammatory reaction, alleviates injury of lung.
From traditional mechanical ventilation gas can safety high speed the feature of turnover air flue different, the viscous force that liquid is larger make liquid ventilation can not be as gas quick turnover air flue.Liquid enters too quickly air flue and causes excessive pressure will make Hyperinflation cause damage, allows liquid the produced negative pressure of breathing out rapidly may make air flue subside, and causes liquid holdup, and current liquid ventilation respirator there is no method and addresses this problem.
Summary of the invention
The technical problem to be solved in the present invention is the deficiency that overcomes above-mentioned background technology, and a kind of total liquid ventilation respirator is provided, and this respirator can accuracy controlling respiration parameter, and airway pressure carries out feedback regulation during to liquid ventilation.
The technical solution used in the present invention is:
A respirator, is provided with liquid carrying path, and this liquid carrying path comprises oxygenator molectron, Buffer Pool and the piston pump molectron that adopts pipeline sequentially to connect into closed circuit, it is characterized in that:
Described oxygenator molectron comprises the first oxygenator and the second oxygenator, and both top adopts conduit to be communicated with, and the air inlet of an external source oxygen is respectively arranged at both bottoms;
The top of described Buffer Pool adopts conduit to be communicated with the second oxygenator;
Described piston pump molectron is comprised of air-breathing piston pump and expiration piston pump; The inlet of air-breathing piston pump adopts conduit to be communicated with the lower end of described Buffer Pool; Between air-breathing piston pump and expiration piston pump, be provided with Y type conduit, the first end of this Y type conduit connects the liquid outlet of air-breathing piston pump, and the second end connects the inlet of expiration piston pump, and the 3rd end connects patient's pulmonary; The liquid outlet of expiration piston pump adopts conduit to be communicated with the first oxygenator.
Described liquid carrying path also comprises two heaters, filter and condensers; Two heaters are separately positioned on the lower end of the first oxygenator and the second oxygenator; The inlet of filter is communicated with the conduit of drawing from the liquid outlet of described expiration piston pump, and the liquid outlet of filter is communicated with the first oxygenator; Condenser is positioned at the top of the second oxygenator.
Described total liquid ventilation respirator also comprises control system, this control system comprises PLC controller and connected touch display screen, two displacement transducers, pressure transducer, two temperature sensors, four electromagnetic valves, and PLC controller is connected with drive motors and two heaters of air-breathing piston pump and expiration piston pump respectively; Two displacement transducers are separately positioned on described expiration piston pump and air-breathing piston pump inside, and pressure transducer is positioned at one end that described Y type conduit is connected with patient, and two temperature sensors lay respectively in the first oxygenator and the second oxygenator; In four electromagnetic valves, No. one valve is arranged on the conduit of drawing from the inlet of air-breathing piston pump, No. two valve is arranged on the conduit of drawing from the liquid outlet of air-breathing piston pump, No. three valve is arranged on the conduit of drawing from the inlet of expiration piston pump, and No. four valve is arranged on the conduit of drawing from the liquid outlet of expiration piston pump.
Operation principle of the present invention is:
User is from touch display screen infusion fluid temperature, each inspiration capacity, each expiration amount and time each air-breathing and that exhale, the heater that is positioned at the first oxygenator and the second oxygenator lower end starts heating liquid, until temperature sensor obtains the temperature data of setting; Each air-breathing and exhale number by controlling the upper and lower displacement of piston in air-breathing piston pump and expiration piston pump, control;
When respirator is started working, first enter expiratory phase, No. one valve is opened, and No. two valve cuts out, No. three valve is opened, No. four valve cuts out, and according to the expiration amount setting in advance, the piston of expiration piston pump moves down, by liquid sucking-off in Patients with Lung, meanwhile, the piston of air-breathing piston pump moves down according to the inspiration capacity that sets in advance, by Buffer Pool the liquid of oxygenate be evacuated in air-breathing piston pump;
So far expiratory phase finishes, inspiratory phase starts, and No. one valve cuts out, and No. two valve is opened, No. three valve cuts out, No. four valve is opened, and on the piston of air-breathing piston pump, moves, and the expiration quantity of fluid setting in advance is sent in Patients with Lung, meanwhile, expiration piston pump moves on also, and breathing phase institute extracting liquid is sent in oxygenator through filter, and so far inspiratory phase finishes;
The oxygen that liquid continues and external source passes into of getting back in oxygenator carries out oxygenate, and the temperature of liquid-retentive being set by heater; After respiration, start second wind, the liquid of carrying complete oxygenate in inspiratory phase, for patient respiratory, reclaims the liquid of hypoxia-hypercapania after patient's gas exchange in expiratory phase, and by liquid oxygenate again, so circulation, guarantees patient's breathing oxygen supply.
The invention has the beneficial effects as follows: it is stable that the present invention's application double-piston pump (all applying independently piston pump in the suction side of liquid ventilation and the end of breathing out) is accurately controlled tidal volume, control and breathe out and suction side flow rate of liquid respectively, realize the flexible regulation and control to negative pressure in air flue and liquid exhalation flow velocity; The present invention simultaneously is also integrated with control system, realizes liquid ventilation parameter, and especially airway pressure Real-Time Monitoring, by setting the bound of liquid breathing pressure, prevents the injury of lung that excessive malleation and negative pressure cause, and guarantees that the safety of liquid ventilation is with efficient.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
The specific embodiment
Below in conjunction with Figure of description, the invention will be further described, but the present invention is not limited to following examples.
As shown in Figure 1, a kind of total liquid ventilation respirator of the present invention, is provided with liquid carrying path, and this liquid carrying path comprises oxygenator molectron, Buffer Pool 3 and the piston pump molectron that adopts pipeline sequentially to connect into closed circuit.
Described oxygenator molectron comprises the first oxygenator 1 and the second oxygenator 2, and both top adopts conduit to be communicated with, and the air inlet of an external source oxygen is respectively arranged at both bottoms, by oxygen intake conduit 10, is connected with external source oxygen; The first oxygenator and the second oxygenator are after external source oxygen enters and liquid (perfluocarbon) carries out the place of oxygenate, and carbon dioxide is discharged in the first oxygenator and the second oxygenator.
The top of described Buffer Pool adopts conduit to be communicated with in side with the second oxygenator, and Buffer Pool is for storing the liquid of oxygenate.
Described piston pump molectron is comprised of air-breathing piston pump 6 and expiration piston pump 9; The inlet A of air-breathing piston pump adopts conduit to be communicated with the lower end of described Buffer Pool; Between air-breathing piston pump and expiration piston pump, be provided with Y type conduit 8, the first end of this Y type conduit connects the liquid outlet B of air-breathing piston pump, and the second end connects the inlet C of expiration piston pump, and the 3rd end connects patient's pulmonary 7; The liquid outlet D of expiration piston pump adopts conduit to be communicated with the first oxygenator.Air-breathing piston pump drives piston to move by drive motors M, the oxygenated solution of Buffer Pool is delivered to patient pulmonary and cures by oxygen therapy, and the liquid that expiration piston pump drives piston to move ，Ba patient pulmonary by drive motors M is carried and got back to circulation again in the first oxygenator.
Described liquid carrying path also comprises two heaters 15, filter 5 and condenser 4; Two heaters are generally Electric heating, are separately positioned on the lower end of the first oxygenator and the second oxygenator; The inlet of filter is communicated with the conduit of drawing from the liquid outlet of described expiration piston pump, and the liquid outlet of filter is communicated with the first oxygenator, and the effect of filter is to filter out in lung to draw the harmful substance that liquid is taken out of, and can change; Condenser is positioned at the top of the second oxygenator, the liquid of volatilization can be collected into the second oxygenator again, and the top of Buffer Pool is also connected with condenser by conduit, and the liquid of volatilization is collected into Buffer Pool again.
Described total liquid ventilation respirator also comprises control system, and this control system comprises PLC controller and connected touch display screen, two displacement transducers, pressure transducer, two temperature sensors, four electromagnetic valves; PLC controller is connected with the drive motors of air-breathing piston pump and expiration piston pump and two heaters respectively and controls drive motors and heater work.Control system in control system in the present invention and existing liquid ventilation respirator is substantially similar, PLC controller, touch display screen, displacement transducer, pressure transducer and temperature sensor that in the present invention, control system adopts are all existing conventional components, for making drawing clean and tidy, in figure, all omitted and do not drawn.
Two displacement transducers are separately positioned on described expiration piston pump and air-breathing piston pump inside, for detection of the position of piston in expiration piston pump and air-breathing piston pump; Pressure transducer is positioned at one end that described Y type conduit is connected with patient, for measuring the pressure that liquid produces herein; Two temperature sensors lay respectively in the first oxygenator and the second oxygenator, are respectively used to temperature of liquid in first, second oxygenator of perception; In four electromagnetic valves, No. one valve 11 is arranged on the conduit of drawing from the inlet of air-breathing piston pump, No. two valve 12 is arranged on the conduit of drawing from the liquid outlet of air-breathing piston pump, No. three valve 13 is arranged on the conduit of drawing from the inlet of expiration piston pump, and No. four valve 14 is arranged on the conduit of drawing from the liquid outlet of expiration piston pump.
In the present invention, the feedback regulation process of control system is as follows: in inspiratory phase, when detecting pressure, pressure transducer is greater than setting value above in limited time, on the piston of air-breathing piston pump stops, moving, No. two valve cuts out, and expiration piston pump continues by predefined expiration amount, liquid to be entered in the first oxygenator; Piston pump discharge opeing to be exhaled completes, and inspiratory phase finishes, and expiratory phase starts, and No. three valve is opened, and No. four valve cuts out, and No. one valve is opened, and No. two valve cuts out, and air-breathing piston pump extracting liquid is to the inspiration capacity setting in advance, and expiration piston pump extracts liquid in Patients with Lung;
In expiratory phase, when pressure transducer detects pressure, be less than setting value lower limit when (can be negative pressure), the piston of expiration piston pump stops moving down, No. three valve cuts out, air-breathing piston pump continue by predefined expiration amount by liquid from Buffer Pool suction pump; Treat that air-breathing piston pump drawing liquid completes, expiratory phase finishes, and inspiratory phase starts, No. one valve cuts out, and No. two valve is opened, and No. three valve cuts out, No. four valve is opened, and expiration piston pump drains into the first oxygenator by the expiration amount setting in advance by liquid, and air-breathing piston pump is sent into liquid in Patients with Lung.
In the inspiratory phase setting pressure upper limit, can prevent the injury of lung that even breaks and cause because of the excessive patient's of the causing pulmonary alveolar overdistension of pressure when air-breathing.At expiratory phase setting pressure lower limit, can prevent from exhaling is that negative pressure is excessive and cause the gas exchange restriction that Patients with Lung interior conduit subsides and causes.
The equal buyable of the first oxygenator in the present invention, the second oxygenator, filter, condenser, air-breathing piston pump, expiration piston pump, PLC controller, each sensor and electromagnetic valve obtains.Arrow express liquid in Fig. 1 flows to.
Claims (3)
1. a total liquid ventilation respirator, is provided with liquid carrying path, and this liquid carrying path comprises oxygenator molectron, Buffer Pool (3) and the piston pump molectron that adopts pipeline sequentially to connect into closed circuit, it is characterized in that:
Described oxygenator molectron comprises the first oxygenator (1) and the second oxygenator (2), and both top adopts conduit to be communicated with, and the air inlet of an external source oxygen is respectively arranged at both bottoms;
The top of described Buffer Pool adopts conduit to be communicated with the second oxygenator;
Described piston pump molectron is comprised of air-breathing piston pump (6) and expiration piston pump (9); The inlet of air-breathing piston pump (A) adopts conduit to be communicated with the lower end of described Buffer Pool; Between air-breathing piston pump and expiration piston pump, be provided with Y type conduit (8), the first end of this Y type conduit connects the liquid outlet (B) of air-breathing piston pump, and the second end connects the inlet (C) of expiration piston pump, and the 3rd end connects patient's pulmonary (7); The liquid outlet of expiration piston pump (D) adopts conduit to be communicated with the first oxygenator.
2. a kind of total liquid ventilation respirator according to claim 1, is characterized in that: described liquid carrying path also comprises two heaters (15), filter (5) and condenser (4); Two heaters are separately positioned on the lower end of the first oxygenator and the second oxygenator; The inlet of filter is communicated with the conduit of drawing from the liquid outlet of described expiration piston pump, and the liquid outlet of filter is communicated with the first oxygenator; Condenser is positioned at the top of the second oxygenator.
3. a kind of total liquid ventilation respirator according to claim 2, it is characterized in that: described total liquid ventilation respirator also comprises control system, this control system comprises PLC controller and connected touch display screen, two displacement transducers, pressure transducer, two temperature sensors, four electromagnetic valves, and PLC controller is connected with drive motors and two heaters of air-breathing piston pump and expiration piston pump respectively; Two displacement transducers are separately positioned on described expiration piston pump and air-breathing piston pump inside, and pressure transducer is positioned at one end that described Y type conduit is connected with patient, and two temperature sensors lay respectively in the first oxygenator and the second oxygenator; In four electromagnetic valves, a valve (11) is arranged on the conduit of drawing from the inlet of air-breathing piston pump, No. two valves (12) are arranged on the conduit of drawing from the liquid outlet of air-breathing piston pump, No. three valves (13) are arranged on the conduit of drawing from the inlet of expiration piston pump, and No. four valves (14) are arranged on the conduit of drawing from the liquid outlet of expiration piston pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310603469.XA CN103585707A (en) | 2013-11-25 | 2013-11-25 | Total liquid ventilation respirator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310603469.XA CN103585707A (en) | 2013-11-25 | 2013-11-25 | Total liquid ventilation respirator |
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| Publication Number | Publication Date |
|---|---|
| CN103585707A true CN103585707A (en) | 2014-02-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310603469.XA Pending CN103585707A (en) | 2013-11-25 | 2013-11-25 | Total liquid ventilation respirator |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105664320A (en) * | 2016-04-17 | 2016-06-15 | 刘家容 | Respirator with aerosol inhalation function for pneumology department |
| CN108014403A (en) * | 2016-07-07 | 2018-05-11 | 李丽倩 | What a kind of division of respiratory disease used has the function of the lung ventilator of Neulized inhalation |
| RU2732639C1 (en) * | 2020-03-26 | 2020-09-21 | Российская Федерация, от имени которой выступает ФОНД ПЕРСПЕКТИВНЫХ ИССЛЕДОВАНИЙ | Device for lung ventilation with fluid |
| CN112770800A (en) * | 2018-04-17 | 2021-05-07 | 索克普拉科学与工程公司 | Liquid ventilator and method of inducing tidal liquid ventilation and/or hypothermia |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5492109A (en) * | 1993-11-03 | 1996-02-20 | The Regents Of The University Of Michigan | Liquid ventilator with venturi-inducing patient connector |
| US20040134486A1 (en) * | 2002-11-29 | 2004-07-15 | Raymond Robert | Method and apparatus for conducting total liquid ventilation with control of residual volume and ventilation cycle profile |
| CN102223908A (en) * | 2009-05-29 | 2011-10-19 | 中村正一 | Gas mist inhaler |
| WO2012062266A1 (en) * | 2010-10-11 | 2012-05-18 | Technische Universität Dresden | Device and method for ventilation |
| CN203694295U (en) * | 2013-11-25 | 2014-07-09 | 姜力骏 | Total liquid ventilation breathing machine |
-
2013
- 2013-11-25 CN CN201310603469.XA patent/CN103585707A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5492109A (en) * | 1993-11-03 | 1996-02-20 | The Regents Of The University Of Michigan | Liquid ventilator with venturi-inducing patient connector |
| US20040134486A1 (en) * | 2002-11-29 | 2004-07-15 | Raymond Robert | Method and apparatus for conducting total liquid ventilation with control of residual volume and ventilation cycle profile |
| CN102223908A (en) * | 2009-05-29 | 2011-10-19 | 中村正一 | Gas mist inhaler |
| WO2012062266A1 (en) * | 2010-10-11 | 2012-05-18 | Technische Universität Dresden | Device and method for ventilation |
| CN203694295U (en) * | 2013-11-25 | 2014-07-09 | 姜力骏 | Total liquid ventilation breathing machine |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105664320A (en) * | 2016-04-17 | 2016-06-15 | 刘家容 | Respirator with aerosol inhalation function for pneumology department |
| CN105664320B (en) * | 2016-04-17 | 2018-01-12 | 北京中川纳德医疗设备有限公司 | The lung ventilator with Neulized inhalation function that a kind of division of respiratory disease uses |
| CN108014403A (en) * | 2016-07-07 | 2018-05-11 | 李丽倩 | What a kind of division of respiratory disease used has the function of the lung ventilator of Neulized inhalation |
| CN108014403B (en) * | 2016-07-07 | 2020-03-31 | 孙慧 | Respirator that has aerosol inhalation function that department of respiration used |
| CN112770800A (en) * | 2018-04-17 | 2021-05-07 | 索克普拉科学与工程公司 | Liquid ventilator and method of inducing tidal liquid ventilation and/or hypothermia |
| RU2732639C1 (en) * | 2020-03-26 | 2020-09-21 | Российская Федерация, от имени которой выступает ФОНД ПЕРСПЕКТИВНЫХ ИССЛЕДОВАНИЙ | Device for lung ventilation with fluid |
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Application publication date: 20140219 |