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CN103550494B - A kind of Chinese medicine composition and preparation method thereof with containing its preparation and application - Google Patents

A kind of Chinese medicine composition and preparation method thereof with containing its preparation and application Download PDF

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CN103550494B
CN103550494B CN201310581682.5A CN201310581682A CN103550494B CN 103550494 B CN103550494 B CN 103550494B CN 201310581682 A CN201310581682 A CN 201310581682A CN 103550494 B CN103550494 B CN 103550494B
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张文山
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Abstract

本发明涉及一种中药组合物及其制备方法与含其制剂和应用,属于中药制药技术领域。所述中药组合物含有以下重量份的原料药:苍术8-15、槟榔10-20、厚朴8-15、枳实8-15、石菖蒲8-12、桔梗8-15、前胡8-15、茯苓8-15、紫苏子8-12、贝母8-12,用于治疗因营养过剩、不科学进食及社会生态的多种复杂因素引起的高血糖、高血压、高血脂、脂肪肝、超重、便秘、便溏、腹胀、胃肠功能紊乱、失眠、心悸、心梗、脑中风、腰酸腿疼、健忘、精神分裂症、阳痿、月经不调、不孕不育、甚至癌症等等,具有疗效好、见效快、治疗疾病谱广、无毒副作用、治疗成本低、无名贵药材、制备方法简单等优点。The invention relates to a traditional Chinese medicine composition, a preparation method thereof, a preparation containing the same and application thereof, and belongs to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine composition contains the following raw materials in parts by weight: 8-15 parts by weight of Atractylodes atractylodes, 10-20 parts of betel nut, 8-15 parts of Magnolia officinalis, 8-15 parts of Citrus aurantium, 8-12 parts of Shichangpu, 8-15 parts of bellflower, and 8-15 parts of Radix Peucedanum. 15. Poria 8-15, Perilla 8-12, Fritillaria 8-12, used to treat hyperglycemia, high blood pressure, hyperlipidemia, fat caused by various complex factors of overnutrition, unscientific eating and social ecology Liver, overweight, constipation, loose stools, abdominal distension, gastrointestinal disorders, insomnia, palpitations, myocardial infarction, stroke, backache and leg pain, forgetfulness, schizophrenia, impotence, irregular menstruation, infertility, and even cancer etc. It has the advantages of good curative effect, quick effect, wide spectrum of disease treatment, no toxic and side effects, low treatment cost, no precious medicinal materials, and simple preparation method.

Description

一种中药组合物及其制备方法与含其制剂和应用A kind of traditional Chinese medicine composition and its preparation method and containing its preparation and application

技术领域technical field

本发明涉及一种组合物及其制备方法与含其制剂和应用,尤其涉及一种中药组合物及其制备方法与含其制剂和应用,属于中药制药技术领域。The invention relates to a composition, a preparation method thereof, a preparation containing the same and an application thereof, in particular to a traditional Chinese medicine composition, a preparation method thereof, a preparation containing the same and application thereof, and belongs to the technical field of traditional Chinese medicine pharmacy.

背景技术Background technique

“富贵病”当今社会因过度吃膏粱厚味、环境破坏、农残量多、垃圾食品、工作紧张、心理复杂引起的有统一特征的一系列病变病种,如高血糖、高血压、高血脂、脂肪肝、超重、便秘、便溏、腹胀、胃肠功能紊乱、失眠、心悸、心梗、脑中风、腰酸腿疼、健忘、精神分裂症、阳痿、月经不调、不孕不育、甚至癌症等等。"Disease of wealth" is a series of pathological diseases with unified characteristics caused by excessive eating of glutinous rice, environmental damage, large amount of pesticide residues, junk food, work stress, and psychological complexity in today's society, such as hyperglycemia, hypertension, hyperlipidemia, Fatty liver, overweight, constipation, loose stools, abdominal distension, gastrointestinal disorders, insomnia, palpitations, myocardial infarction, stroke, backache and leg pain, forgetfulness, schizophrenia, impotence, irregular menstruation, infertility, and even cancer etc.

目前治疗此类病的药物大多是“头痛治头”的单一方法,或按传统方法脾虚补脾,肾虚补肾,脱离了当今人们普遍营养过剩而生病的实际,效果不佳。Most of the medicines for the treatment of this type of disease at present are the single method of "treating the head with headache", or according to the traditional method of nourishing the spleen due to spleen deficiency, and nourishing the kidney due to kidney deficiency.

发明内容Contents of the invention

本发明要解决的问题是克服现有技术之缺陷提供一种中药组合物及其制备方法与含其制剂和应用,该中药组合物针对因营养过剩、不科学进食及社会生活的多种复杂因素引起的体内壅滞堵塞,火毒、腐物、淤血、郁气、宿便、宿食、痰浊、湿秽等“垃圾”,进而影响了五脏六腑相生相克健康运行的平衡状态,造成身体失衡所产生的病症,疾病谱较广。The problem to be solved by the present invention is to overcome the defects of the prior art and provide a Chinese medicine composition and its preparation method and its preparation and application. The stagnation and blockage in the body caused by fire, poison, decay, congestion, depression, stool, food, phlegm, dampness and other "garbage" will affect the balance of the internal organs and the six internal organs. The disease has a broad spectrum of diseases.

本发明所述的中药组合物,能够清除心、肝、脾、肺、肾、胃肠、胆、膀胱、子宫、血脉等器官中的“垃圾”,使身体运行机制恢复正常,从而治愈此类病症,具有疗效好,见效快,治疗疾病谱广,无毒副作用,治疗成本低,无名贵药材,制备方法简单等优点。The traditional Chinese medicine composition of the present invention can remove the "garbage" in organs such as the heart, liver, spleen, lung, kidney, gastrointestinal tract, gallbladder, bladder, uterus, blood vessels, etc., and restore the body's operating mechanism to normal, thereby curing such diseases. The disease has the advantages of good curative effect, quick effect, wide spectrum of disease treatment, no toxic and side effects, low treatment cost, no rare medicinal materials, simple preparation method and the like.

本发明所述技术问题是由以下技术方案实现的。The technical problems described in the present invention are achieved by the following technical solutions.

一种中药组合物,含有如下重量份的原料药:A kind of Chinese medicine composition, contains the raw material drug of following weight portion:

苍术8-15、槟榔10-20、厚朴8-15、枳实8-15、石菖蒲8-12、桔梗8-15、前胡8-15、茯苓8-15、紫苏子8-12、贝母8-12。Atractylodes 8-15, Betel nut 10-20, Magnolia officinalis 8-15, Citrus aurantii 8-15, Shichangpu 8-12, Campanulaceae 8-15, Peucedanum 8-15, Poria cocos 8-15, Perilla 8-12 , Fritillaria 8-12.

优选的,上述中药组合物,含有如下重量份的原料药:Preferably, the above-mentioned Chinese medicine composition contains the following raw materials in parts by weight:

苍术10、槟榔12、厚朴10、枳实10、石菖蒲10、桔梗12、前胡10、茯苓12、紫苏子10、贝母10。Atractylodes 10, Betel nut 12, Magnolia officinalis 10, Citrus aurantium 10, Shichangpu 10, Campanulaceae 12, Peucedanum 10, Poria 12, Perilla 10, Fritillaria 10.

作为本发明的另一种方案,上述中药组合物,其还含有如下重量份原料药:As another solution of the present invention, the above-mentioned Chinese medicine composition also contains the following raw materials in parts by weight:

三棱10-15、莪术10-15、黄芩10-15、金银花15-20、败酱10-15、莱菔子10-15、大黄6-10、丹皮10-15、山楂10-15。Sanleng 10-15, Curcuma 10-15, Scutellaria baicalensis 10-15, Honeysuckle 15-20, Patonia 10-15, Lai Fuzi 10-15, Rhubarb 6-10, Paeonol 10-15, Hawthorn 10-15.

优选的,上述中药组合物,其还含有如下重量份原料药:Preferably, the above-mentioned Chinese medicine composition also contains the following raw materials in parts by weight:

三棱12、莪术12、黄芩12、金银花18、败酱12、莱菔子12、大黄8、丹皮12、山楂12。Sanleng 12, Curcuma 12, Scutellaria baicalensis 12, Honeysuckle 18, Patonia 12, Laifuzi 12, Rhubarb 8, Paeonol 12, Hawthorn 12.

上述中药组合物的制备方法为A、按照重量份数称取原料药,将称好的原料药混合、杀菌、装袋,煎煮成汤剂服用;或,B、按照重量份数称取原料,将原料药洗净灭菌后粉碎成200目-500目的细粉装零号胶囊即可;或,C、按照重量份数称取原料药后,使用中药提取方法,如水煎煮法、浸渍法、渗漉法、改良明胶法、回流法、溶剂提取法、水蒸气蒸馏法、升华法、酶提取法、半仿生提取法、超临界流体萃取、膜提取分离技术、超微粉碎技术以及中药絮凝分离技术等,获得提取物,再和一种或多种药学上可以接受的载体或赋形剂制备成临床可用的剂型形式。The preparation method of the above-mentioned traditional Chinese medicine composition is A. Weighing the raw material according to the parts by weight, mixing the weighed raw material, sterilizing, bagging, and decocting it into a decoction for taking; or, B. Weighing the raw material according to the parts by weight , wash and sterilize the raw material drug and crush it into a fine powder of 200 mesh to 500 mesh and put it in a zero-sized capsule; method, percolation method, improved gelatin method, reflux method, solvent extraction method, steam distillation method, sublimation method, enzyme extraction method, semi-bionic extraction method, supercritical fluid extraction, membrane extraction and separation technology, ultrafine pulverization technology and traditional Chinese medicine Flocculation separation technology, etc., to obtain the extract, and then prepare it into a clinically usable dosage form with one or more pharmaceutically acceptable carriers or excipients.

一种药物制剂,其含有上述中药组合物的粉末、提取浸膏、有效部位或有效成分。A pharmaceutical preparation, which contains the powder, extraction extract, effective part or active ingredient of the above-mentioned traditional Chinese medicine composition.

上述药物制剂,包括供口服用的胶囊、片剂、软胶囊、口服液、颗粒剂、糖浆、滴丸、水丸、蜜丸以及缓控释制剂等,供注射用的水针注射液、冻干粉针、无菌粉针以及大输液等。The above-mentioned pharmaceutical preparations include capsules, tablets, soft capsules, oral liquids, granules, syrups, dripping pills, water pills, honeyed pills and sustained-release preparations for oral use, water injections for injection, freeze-dried Powder injection, sterile powder injection and large infusion, etc.

上述中药组合物在制备用于治疗“富贵病”药物中的应用。Application of the above-mentioned traditional Chinese medicine composition in the preparation of medicines for treating "rich man's disease".

所述“富贵病”为因营养过剩、不科学进食及社会生活的多种复杂因素引起的人体内壅滞堵塞,火毒、腐物、淤血、郁气、宿便、宿食、痰浊、湿秽等“垃圾”,进而影响了五脏六腑相生相克健康运行的平衡状态,造成身体失衡所产生的病症,如高血糖、高血压、高血脂、脂肪肝、超重、便秘、便溏、腹胀、胃肠功能紊乱、失眠、心悸、心梗、脑中风、腰酸腿疼、健忘、精神分裂症、阳痿、月经不调、不孕不育、甚至癌症等等。The "rich man's disease" is due to overnutrition, unscientific eating and various complex factors in the human body caused by stagnation and blockage in the human body, fire poison, putrefaction, congestion, depression, stool, persistent food, phlegm, dampness Waiting for "garbage", which in turn affects the balance of the internal organs and the six internal organs, and causes the diseases caused by the imbalance of the body, such as hyperglycemia, high blood pressure, hyperlipidemia, fatty liver, overweight, constipation, loose stool, abdominal distension, gastrointestinal function Disorder, insomnia, heart palpitations, myocardial infarction, stroke, backache and leg pain, forgetfulness, schizophrenia, impotence, irregular menstruation, infertility, and even cancer, etc.

本发明所述中药组合物的用法及用量,如为汤剂,则每日一付,早晚各服一次;如为粉碎后直接装入的零号胶囊剂,则每日10粒,早中个3粒,晚4粒;如为使用提取技术获得的提取物进而与相应辅料制备而成的制剂,则应根据制剂中药物活性成分的含量来设定用法用量。The usage and dosage of the traditional Chinese medicine composition of the present invention, if it is a decoction, one dose per day, once in the morning and evening; 3 capsules, 4 capsules later; if it is a preparation prepared by using the extract obtained by extraction technology and the corresponding auxiliary materials, the usage and dosage should be set according to the content of the active ingredients in the preparation.

本发明所述中药组合物与现有技术相比所具有的有效效果是:本发明所述中药组合物在继承传统中药理论和实践的基础上有所创新和发展:①传统中医治疗方法中采用补泄结合,补多泄少;因当前人们生活水平高,肉蛋油多,不用药补,所以本发明所述中药组合物针对当今普遍存在的营养过剩的“富贵病”,基本采用清泄法,疗效很好。②传统中医理论中多见脾虚、肾虚、肺虚,少见脾实、肾实、肺实之观点;本发明所述中药组合物依当今富裕的生活实际,发现脾实、肾实、肺实比比皆是,因此大胆用泄脾、清肾、清肺之法,效果很好。③本发明所述中药组合物不是治一种病,而是治一类病,涉及到内、外、妇、儿多科种,凡是因吃而产生的病可达几十甚至上百种,用本发明所述中药组合物皆有效。因此具有广阔广泛的医疗价值及社会和经济意义。④在研究本发明所述中药组合物的过程中,发现部分中草药比教科书上列出的作用要多,如凉血药能使粘稠血液祛瘀化清;化痰止咳药能去五脏之秽物;清导药不仅通便还能去火毒、痰湿,还能使部分“垃圾”化废为正,为身体所吸收等,业已发现“富贵病”涉及三十余种,所用本发明所述中药组合物有效率几乎达百分之百,因为凡是清理了五脏“垃圾”,犹如车辆经过一次大保养,许多毛病迎刃而解。对高血压、高血糖病治愈率可达30%,属五脏机能问题的可以治疗,属遗传性、长期性、不明原因性的治疗不明显,但可消除其并发症,对脂肪肝、脾胃、肥胖类病效果更好。Compared with the prior art, the Chinese medicine composition of the present invention has the following effective effects: the Chinese medicine composition of the present invention innovates and develops on the basis of inheriting traditional Chinese medicine theory and practice: Combination of nourishing and venting, more tonic and less venting; because the current people's living standard is high, meat, eggs and oil are more, and no medicine is used for tonic, so the traditional Chinese medicine composition of the present invention basically adopts the method of clearing venting for the "rich man's disease" of overnutrition that is ubiquitous today. , the curative effect is very good. ② In traditional Chinese medicine theory, spleen deficiency, kidney deficiency, and lung deficiency are often seen, and spleen excess, kidney excess, and lung excess are rarely seen; the traditional Chinese medicine composition of the present invention is based on the reality of today's affluent life, and it is found that the ratio of spleen excess, kidney excess, and lung excess Both are, so boldly use the method of venting the spleen, clearing the kidney, and clearing the lung, and the effect is very good. ③The traditional Chinese medicine composition of the present invention does not treat one kind of disease, but treats one kind of disease, involving many kinds of internal medicine, surgery, gynecology and pediatrics, and the diseases caused by eating can reach dozens or even hundreds of kinds. It is all effective with the traditional Chinese medicine composition described in the present invention. Therefore, it has broad medical value and social and economic significance. ④ In the process of studying the Chinese medicine composition of the present invention, it was found that some Chinese herbal medicines have more effects than those listed in textbooks, such as blood-cooling medicines that can dispel blood stasis and clear blood; clearing and guiding medicine can not only laxative but also eliminate fire, poison and phlegm dampness, and can also turn part of the "garbage" into righteousness, which can be absorbed by the body. The effective rate of the above-mentioned Chinese medicine composition is almost 100%, because all the "garbage" of the five internal organs is cleaned up, just like a car after a major maintenance, many problems can be easily solved. The cure rate for high blood pressure and hyperglycemia can reach 30%. It can be used to treat the problems of the five internal organs. The treatment of hereditary, long-term and unexplained diseases is not obvious, but its complications can be eliminated. Fatty liver, spleen and stomach, Obesity is better.

具体实施方式Detailed ways

下面结合具体实施方式对本发明作进一步详细说明。The present invention will be further described in detail below in combination with specific embodiments.

实施例1本发明所述的中药组合物,包括如下重量份原料药Embodiment 1 The Chinese medicine composition of the present invention comprises the following parts by weight of crude drug

苍术8g、槟榔10g、厚朴8g、枳实8g、石菖蒲8g、桔梗8g、前胡8g、茯苓8g、紫苏子8g、贝母8g。Atractylodes 8g, Betel nut 10g, Magnolia officinalis 8g, Citrus aurantium 8g, Shichangpu 8g, Campanulaceae 8g, Peucedanum 8g, Poria 8g, Perilla 8g, Fritillaria 8g.

其制备方法如下:Its preparation method is as follows:

方法A、按照上述重量份数称取原料药,将称好的原料药混合、杀菌、装包装袋即可。Method A: Weigh the bulk drug according to the above parts by weight, mix the weighed bulk drug, sterilize it, and pack it into a bag.

方法B、按照上述重量份数称取原料药,将原料药洗净灭菌后粉碎成200目-500目的细粉装零号胶囊即可。Method B: Weigh the crude drug according to the above parts by weight, wash and sterilize the crude drug, crush it into a fine powder of 200 mesh to 500 mesh, and pack it into a zero-size capsule.

方法C、按照上述重量份数称取原料药,粉碎,加水煎煮三次,每次1小时,合并煎液,滤过,滤液浓缩成相对密度为1.20(60℃)的浸膏,在80℃下减压干燥,细粉加入植物油至总量为600g,过胶体磨研磨20分钟,制成软胶囊1000粒,即得。Method C. Weigh the crude drug according to the above parts by weight, pulverize it, add water to decoct three times, 1 hour each time, combine the decoction, filter, and concentrate the filtrate into an extract with a relative density of 1.20 (60°C). Dry under reduced pressure, add vegetable oil to the fine powder until the total amount is 600g, pass through a colloid mill to grind for 20 minutes, and make 1000 soft capsules.

实施例2本发明所述的中药组合物,包括如下重量份原料药Embodiment 2 The Chinese medicine composition of the present invention comprises the following raw materials in parts by weight

苍术10g、槟榔12g、厚朴10g、枳实10g、石菖蒲10g、桔梗12g、前胡10g、茯苓12g、紫苏子10g、贝母10g。Atractylodes 10g, Betel nut 12g, Magnolia officinalis 10g, Citrus aurantium 10g, Shichangpu 10g, Campanulaceae 12g, Peucedanum 10g, Poria cocos 12g, Perilla 10g, Fritillaria 10g.

其制备方法如下:Its preparation method is as follows:

方法A、按照上述重量份数称取原料药,将称好的原料药混合、杀菌、装包装袋即可。Method A: Weigh the bulk drug according to the above parts by weight, mix the weighed bulk drug, sterilize it, and pack it into a bag.

方法B、按照上述重量份数称取原料药,将原料药洗净灭菌后粉碎成200目-500目的细粉装零号胶囊即可。Method B: Weigh the crude drug according to the above parts by weight, wash and sterilize the crude drug, crush it into a fine powder of 200 mesh to 500 mesh, and pack it into a zero-size capsule.

方法C、按照上述重量份数称取原料药,超微化到5-30um药粉细度装入胶囊,即可。实施例3本发明所述的中药组合物,包括如下重量份原料药Method C: Weigh the crude drug according to the above weight parts, ultramicronize the drug powder to a fineness of 5-30um, and pack it into a capsule. Embodiment 3 The Chinese medicine composition of the present invention comprises the following raw materials in parts by weight

苍术15g、槟榔20g、厚朴15g、枳实15g、石菖蒲12g、桔梗15g、前胡15g、茯苓15g、紫苏子15g、贝母12g。Atractylodes 15g, Betel nut 20g, Magnolia officinalis 15g, Citrus aurantium 15g, Shichangpu 12g, Campanulaceae 15g, Peucedanum 15g, Poria 15g, Perilla 15g, Fritillaria 12g.

其制备方法如下:Its preparation method is as follows:

方法A、按照上述重量份数称取原料药,将称好的原料药混合、杀菌、装包装袋即可。Method A: Weigh the bulk drug according to the above parts by weight, mix the weighed bulk drug, sterilize it, and pack it into a bag.

方法B、按照上述重量份数称取原料药,将原料药洗净灭菌后粉碎成200目-500目的细粉装零号胶囊即可。Method B: Weigh the crude drug according to the above parts by weight, wash and sterilize the crude drug, crush it into a fine powder of 200 mesh to 500 mesh, and pack it into a zero-size capsule.

方法C、按照上述重量份数称取原料药,超微化到5-30um药粉细度装入胶囊,即可。实施例4本发明所述的中药组合物,包括如下重量份原料药Method C: Weigh the crude drug according to the above weight parts, ultramicronize the drug powder to a fineness of 5-30um, and pack it into a capsule. Embodiment 4 The traditional Chinese medicine composition of the present invention comprises the following raw materials in parts by weight

苍术8g、槟榔10g、厚朴8g、枳实8g、石菖蒲8g、桔梗8g、前胡8g、茯苓8g、紫苏子8g、贝母8g、三棱10g、莪术10g、黄芩10g、金银花15g、败酱10g、莱菔子10g、大黄6g、丹皮10g、山楂10gAtractylodes 8g, Betel nut 10g, Magnolia officinalis 8g, Citrus aurantium 8g, Shichangpu 8g, Campanulaceae 8g, Peucedanum 8g, Poria 8g, Perilla 8g, Fritillaria 8g, Sanleng 10g, Curcuma 10g, Scutellaria baicalensis 10g, Honeysuckle 15g, 10g of papaya, 10g of radish, 6g of rhubarb, 10g of paeonol, 10g of hawthorn

其制备方法如下:Its preparation method is as follows:

方法A、按照上述重量份数称取原料药,将称好的原料药混合、杀菌、装包装袋即可。Method A: Weigh the bulk drug according to the above parts by weight, mix the weighed bulk drug, sterilize it, and pack it into a bag.

方法B、按照上述重量份数称取原料药,将原料药洗净灭菌后粉碎成200目-500目的细粉装零号胶囊即可。Method B: Weigh the crude drug according to the above parts by weight, wash and sterilize the crude drug, crush it into a fine powder of 200 mesh to 500 mesh, and pack it into a zero-size capsule.

方法C、按照上述重量份数称取原料药,粉碎,加水煎煮三次,每次1小时,合并煎液,滤过,滤液浓缩成相对密度为1.20(60℃)的浸膏,在80℃下减压干燥,得细粉备用;Method C. Weigh the crude drug according to the above parts by weight, pulverize it, add water to decoct three times, 1 hour each time, combine the decoction, filter, and concentrate the filtrate into an extract with a relative density of 1.20 (60°C). Dry under reduced pressure to obtain fine powder for subsequent use;

将上述物料混匀压片,即制得片剂。The above materials are mixed and pressed into tablets to obtain tablets.

实施例5本发明所述的中药组合物,包括如下重量份原料药Embodiment 5 The Chinese medicine composition of the present invention comprises the following raw materials in parts by weight

苍术10g、槟榔12g、厚朴10g、枳实10g、石菖蒲10g、桔梗12g、前胡10g、茯苓12g、紫苏子10g、贝母10g、三棱12g、莪术12g、黄芩12g、金银花18g、败酱12g、莱菔子12g、大黄8g、丹皮12g、山楂12gAtractylodes 10g, Betel nut 12g, Magnolia officinalis 10g, Citrus aurantium 10g, Shichangpu 10g, Campanulaceae 12g, Peucedanum 10g, Poria 12g, Perilla 10g, Fritillaria 10g, Trigonum 12g, Curcuma 12g, Scutellaria baicalensis 12g, Honeysuckle 18g, 12g papaya, 12g radish, 8g rhubarb, 12g paeonol, 12g hawthorn

其制备方法如下:Its preparation method is as follows:

方法A、按照上述重量份数称取原料药,将称好的原料药混合、杀菌、装包装袋即可。Method A: Weigh the bulk drug according to the above parts by weight, mix the weighed bulk drug, sterilize it, and pack it into a bag.

方法B、按照上述重量份数称取原料药,将原料药洗净灭菌后粉碎成200目-500目的细粉装零号胶囊即可。Method B: Weigh the crude drug according to the above parts by weight, wash and sterilize the crude drug, crush it into a fine powder of 200 mesh to 500 mesh, and pack it into a zero-size capsule.

方法C、按照上述重量份数称取原料药,粉碎,加水煎煮三次,每次1小时,合并煎液,滤过,滤液浓缩成相对密度为1.20(60℃)的浸膏,在80℃下减压干燥,得细粉备用;Method C. Weigh the crude drug according to the above parts by weight, pulverize it, add water to decoct three times, 1 hour each time, combine the decoction, filter, and concentrate the filtrate into an extract with a relative density of 1.20 (60°C). Dry under reduced pressure to obtain fine powder for subsequent use;

将内容物与软质囊壳的胶液放入压丸机,即制得软胶囊。The glue solution of the content and the soft capsule shell is put into a pill press machine to obtain a soft capsule.

实施例6本发明所述的中药组合物,包括如下重量份原料药Embodiment 6 The traditional Chinese medicine composition of the present invention comprises the following raw materials in parts by weight

苍术15g、槟榔20g、厚朴15g、枳实15g、石菖蒲12g、桔梗15g、前胡15g、茯苓15g、紫苏子15g、贝母12g、三棱15g、莪术15g、黄芩15g、金银花20g、败酱15g、莱菔子15g、大黄10g、丹皮15g、山楂15gAtractylodes 15g, Betel nut 20g, Magnolia officinalis 15g, Citrus aurantium 15g, Shichangpu 12g, Campanulaceae 15g, Peucedanum 15g, Poria cocos 15g, Perilla 15g, Fritillaria 12g, Sanleng 15g, Curcuma 15g, Scutellaria baicalensis 15g, Honeysuckle 20g, 15g of papaya, 15g of radish, 10g of rhubarb, 15g of paeonol, 15g of hawthorn

其制备方法如下:Its preparation method is as follows:

方法A、按照上述重量份数称取原料药,将称好的原料药混合、杀菌、装包装袋即可。Method A: Weigh the bulk drug according to the above parts by weight, mix the weighed bulk drug, sterilize it, and pack it into a bag.

方法B、按照上述重量份数称取原料药,将原料药洗净灭菌后粉碎成200目-500目的细粉装零号胶囊即可。Method B: Weigh the crude drug according to the above parts by weight, wash and sterilize the crude drug, crush it into a fine powder of 200 mesh to 500 mesh, and pack it into a zero-size capsule.

方法C、按照上述重量份数称取原料药,粉碎,加水煎煮三次,每次1小时,合并煎液,滤过,滤液浓缩成相对密度为1.20(60℃)的浸膏,在80℃下减压干燥,得细粉备用,与辅料制成口服液即可。Method C. Weigh the crude drug according to the above parts by weight, pulverize it, add water to decoct three times, 1 hour each time, combine the decoction, filter, and concentrate the filtrate into an extract with a relative density of 1.20 (60°C). Dry under reduced pressure to obtain fine powder for later use, and prepare oral liquid with auxiliary materials.

一、临床治疗资料1. Clinical treatment data

采用本发明所述中药组合物共治病63例“富贵病”患者,男41例,女性21例,年龄最大82岁,最小6岁。A total of 63 patients with "rich man's disease" were treated with the traditional Chinese medicine composition of the present invention, including 41 males and 21 females, the oldest being 82 years old and the youngest 6 years old.

(一)临床状态:“富贵病”的共同特点,大多身体超重,个别身体瘦弱,往往脂肪肝、高血脂、高血压、高血糖症同时兼有或具一两种,便秘或便溏、肠胃炎、失眠健忘、急躁、前列腺炎、阳痿、早泄、不育、月经失调、白带多、不孕、心脑血管病早发,还有一些身体局部冷凉、洗手水凉急大便、口腔溃疡多年不愈、不停咳唾,饭后酒后呛饭唾多,颈后生疮手术后还发生等等怪病杂症。口臭口甜,舌红苔白、黄、灰,重者黑,湿厚腻,脉多滑、弦沉、涩、濡、弱。这些大多为“富贵病”导致五脏内存火毒、痰浊、湿秽、聚积、郁气之症状。(1) Clinical status: The common characteristics of "rich man's disease", most of them are overweight, some of them are thin, often have fatty liver, hyperlipidemia, hypertension, hyperglycemia at the same time or both, constipation or loose stool, gastroenteritis , insomnia, forgetfulness, irritability, prostatitis, impotence, premature ejaculation, infertility, menstrual disorders, leucorrhea, infertility, early onset of cardiovascular and cerebrovascular diseases, and some body parts are cold, handwashing water is cold and urgent to defecate, and oral ulcers have not occurred for many years Healing, coughing saliva non-stop, excessive saliva after eating and drinking, sores on the back of the neck and other strange diseases and miscellaneous diseases after surgery. Bad breath, sweet mouth, red tongue with white, yellow, gray fur, black in severe cases, thick and greasy wet, slippery, deep string, astringent, wet, weak pulse. Most of these are symptoms of "rich man's disease" that causes fire poison, phlegm turbidity, dampness, accumulation, and stagnant qi in the five internal organs.

(二)治疗方法:清火解毒,涤痰利湿,理气清浊,消积导滞以达清理五脏、恢复机能、平衡健康之目的:(2) Treatment methods: clearing fire and detoxification, clearing phlegm and promoting dampness, regulating qi and clearing turbidity, eliminating stagnation and stagnation to achieve the purpose of clearing five viscera, restoring function, and balancing health:

(1)将本发明实施例5所述的中药组合物按照常规方法煎熬成汤剂,每日一剂分早晚两次服用;(1) The traditional Chinese medicine composition described in Example 5 of the present invention is decocted into a decoction according to a conventional method, and one dose is taken twice a day in the morning and evening;

(2)将本发明实施例5所述的中药组合物制成的胶囊,每日十粒,早、中各3粒,晚上4粒,胶囊剂为不方便或不能服用汤剂者或需要长时间服药者所设。(2) Capsules made from the traditional Chinese medicine composition described in Example 5 of the present invention, ten capsules per day, three capsules each in the morning and midday, and four capsules in the evening. Time medication is set.

(三)典型病例(3) Typical cases

(1)张某,女,62岁,患高血压两年,血压160/120mmHg,靠西药降压片维持,同时患肾结石,术后肾衰,浑身无力,腿疼,时常头晕。观其体胖、问其爱吃肉、炒菜油多、舌红苔白腻,脉弦数滑,诊断为“富贵病”导致血粘、痰湿。服用本发明所述中药组合物胶囊两个月,血压降为140/100mmHg,又服两个月,血压降为130/85mmHg,同时,头晕、腿疼、浑身无力等症状消失。嘱咐其饮食清淡,随访无反弹。(1) Zhang, female, 62 years old, suffered from high blood pressure for two years, blood pressure 160/120mmHg, maintained by Western medicine Jiangya tablets, and suffered from kidney stones at the same time, renal failure after surgery, general weakness, leg pain, and frequent dizziness. Observing his body fat, asking him about his love for meat, cooking with a lot of oil, red tongue with white and greasy coating, stringy and slippery pulse, he was diagnosed as "rich man's disease" causing sticky blood and phlegm dampness. After taking the traditional Chinese medicine composition capsule of the present invention for two months, the blood pressure dropped to 140/100mmHg, and after taking it for two months, the blood pressure dropped to 130/85mmHg. Meanwhile, symptoms such as dizziness, leg pain, and weakness disappeared. Advise its light diet, follow up a case by regular visits to and have no rebound.

(2)李某,男,40岁,空腹血糖7.5mmol/L,常年便秘,其为公务员,常年一半时间在饭店就餐,烟酒肉不断,体胖腹大,舌红苔黄腻,脉滑弦,诊断为“富贵病”,脾实胰脏功能受影响。服用本发明所述中药组合物汤剂,两个月后血糖降为6.9mmol/L,又服两个月,血糖降为6.4mmol/L,便秘等症状消失。嘱咐其吃适宜糖尿病患者的饮食,戒烟少酒,随访无反弹。(2) Li, male, 40 years old, fasting blood sugar 7.5mmol/L, constipated all the year round, he is a civil servant, eats in restaurants for half of the time, smokes, drinks and eats constantly, fat and belly, red tongue with yellow greasy coating, slippery pulse String, diagnosed as "rich man's disease", the function of the spleen and pancreas is affected. Take the Chinese medicine composition decoction of the present invention, blood sugar drops to 6.9mmol/L after two months, takes again two months, blood sugar drops to 6.4mmol/L, symptoms such as constipation disappear. Advise it to eat the diet suitable for diabetics, quit smoking and drink less, follow up a case by regular visits to and have no rebound.

(3)张某,男,31岁,高脂血症、阳痿,其为个体老板,常年开车,不规律劳作,烟酒肉每顿皆有,常年不在家吃饭,舌苔白黄厚腻,脉滑濡,诊断为“富贵病”综合征,服用本发明所述中药组合物汤剂两个月后,阳痿消失,高脂血症检查与之前相比好转,又服两个月,高血脂数据正常,嘱咐其饮食清淡,随访无反弹。(3) Zhang, male, 31 years old, hyperlipidemia, impotence, self-employed, driving all year round, working irregularly, smoking, drinking and meat every meal, not eating at home all the year round, white and yellow thick greasy tongue coating, pulse Huayu, diagnosed as "rich man's disease" syndrome, after taking the traditional Chinese medicine composition decoction of the present invention for two months, impotence disappeared, and the hyperlipidemia examination was better than before, and after taking it for two months, the hyperlipidemia data was normal , enjoin its light diet, follow up a case by regular visits to and have no rebound.

(4)刘某,男,59岁,中度脂肪肝,空腹血糖12mmol/L,苔腻脉滑、沉、略数。嗜睡并且饭后逾重,体胖困倦,无精神。诊断为“富贵病”引起的诸病。经服本发明所述中药组合物汤剂两个月,脂肪肝变为轻度,血糖降为11mmol/L。又服两个月,脂肪肝仍有,但检查者认为较轻不报,血糖降为10.6mmol/L,之前各种不适症状消失,又服一个月,血糖无降低,但精神好,浑身有劲,无任何并发症。(4) Liu, male, 59 years old, with moderate fatty liver, fasting blood sugar 12mmol/L, greasy fur, slippery, heavy, slight pulse. Lethargy and overweight after meals, fat and sleepy, lack of energy. Diagnosed as various diseases caused by "rich man's disease". After taking the traditional Chinese medicine composition decoction of the present invention for two months, the fatty liver became mild, and the blood sugar dropped to 11mmol/L. After taking it for another two months, the fatty liver still remained, but the examiner thought it was mild and did not report it. The blood sugar dropped to 10.6mmol/L. All the symptoms disappeared. After taking it for another month, the blood sugar did not drop, but he was in good spirits and energetic. , without any complications.

(5)陆某,女,25岁,肥胖重135斤身高159cm,月经提前或推后,白带多,不规律吃饭,经常吃羊头串、方便面等垃圾食品,或早饭不吃,或中午大鱼大肉。苔腻、脉滑数,诊断为“富贵病”,服用本发明所述中药组合物汤剂一个月病情好转,两个月,体重减10斤,月经正常。嘱咐其清淡饮食,而后服本发明所述中药组合物胶囊剂巩固,随访情况良好。(5) Lu, female, 25 years old, obese, weighing 135 catties, height 159 cm, early or late menstruation, excessive leucorrhea, irregular meals, often eating junk food such as kebabs, instant noodles, or skipping breakfast, or having big meals at noon Fish and meat. Greasy fur, slippery and rapid pulse, diagnosed as "wealthy disease", took a month of Chinese medicine composition decoction of the present invention and the condition took a turn for the better, and in two months, body weight lost 10 jins, and menstruation was normal. Advise its light diet, then obey the Chinese medicine composition capsule of the present invention and consolidate, and follow up a case by regular visits to is good.

(6)郭某,男,61岁,超重(身高168cm,体重160斤),患高血压(120-160mmHg)、脂肪肝、健忘、浑身无力、腿软、上一层楼便喘气、肩疼、本人不吃肉,但炒菜油放特多,舌苔黄,脉滑濡,仍为当今之“富贵病”,服用本发明所述中药组合物汤剂一个半月,体重下降12斤,反应变快、肩腿均好转,又服一个月汤剂,脂肪肝为轻度,血压110-140mmHg,又服一个月,脂肪肝好转,血压100-130mmHg,其他症状消失,精神好转,改服胶囊剂巩固。(6) Guo, male, 61 years old, overweight (height 168cm, weight 160kg), suffering from high blood pressure (120-160mmHg), fatty liver, forgetfulness, general weakness, weak legs, panting when going up a floor, shoulder pain 1. I don’t eat meat, but I put a lot of cooking oil, my tongue coating is yellow, and my pulse is slippery. It is still a "rich man's disease" today. After taking the Chinese medicine composition decoction of the present invention for one and a half months, my body weight dropped by 12 jin, and my reaction became faster. Both shoulders and legs improved, and I took the decoction for another month. The fatty liver was mild, and the blood pressure was 110-140mmHg. After taking it for another month, the fatty liver improved, and the blood pressure was 100-130mmHg.

(7)马某,男,63岁,因肺癌切除左肺,因此身体极度虚弱,省医院不再进行化疗,医生说寿命不会超过两个月,无奈求助中医,问其情况知其由电焊空气长期污染和食品农残量多引发肺癌,加之过度劳累,吃饭不规律,舌红苔剥裂黄灰,脉沉弱短滑,诊断仍为当今社会因素引起的疾病,内毒火污染演变为癌,同时瘀血、郁气、痰湿影响五脏功能运行。服用本发明所述中药组合物汤剂,一周后腹腔积水消失,不再抽水,一个月后想吃食物,身上有劲,面色由黄黑变淡红,服用本发明所述中药组合物汤剂三个月体重共增加二十斤,说话由无声变为有声响,面色红润,能干轻微活儿,目前继续服药。(7) Ma, male, 63 years old, was extremely weak due to the resection of his left lung due to lung cancer. The provincial hospital no longer performed chemotherapy. The doctor said that his life expectancy would not exceed two months. He had no choice but to seek help from traditional Chinese medicine. Long-term air pollution and large amounts of pesticide residues in food can cause lung cancer, combined with overwork, irregular eating, red tongue with peeling yellow and gray coating, deep, weak and short slippery pulse, the diagnosis is still a disease caused by current social factors, internal poison fire pollution has evolved cancer, while blood stasis, stagnant qi, and phlegm-dampness affect the functioning of the five internal organs. Take the Chinese medicine composition decoction of the present invention, after one week, the hydroperitoneum disappears, no longer draw water, want to eat food after one month, have energy on one's body, complexion changes light red by yellow black, take the Chinese medicine composition decoction of the present invention In three months, her body weight increased by 20 catties, her speech changed from silent to loud, her complexion was ruddy, and she was able to do light work. Currently, she continues to take medicine.

(8)贾某,男,6岁,因瘦弱面色黄、身高不变化而来求医。问其得知,不按时就餐,姥姥宠爱有加,只吃饼干、肉串等塑料袋包装的垃圾食品,基本不吃菜,查舌干黄脉滑,便秘,诊断为“富贵病”引起的脾肾功能紊乱。服用本发明所述中药组合物汤剂,半个月后,其十分爱吃食物,即嘱咐其吃大量新鲜蔬菜和肉蛋,一个月后,体重增加5斤,面色红华,精神好了起来。(8) Jia, male, 6 years old, came to seek medical treatment because of emaciation, yellow complexion and unchanged height. Ask him to learn that he does not eat on time, his grandma loves him very much, he only eats biscuits, meat skewers and other junk food packaged in plastic bags, and basically does not eat vegetables. His tongue is dry, yellow and slippery, and he is constipated. Kidney disorders. After taking the traditional Chinese medicine composition decoction described in the present invention, after half a month, he liked to eat food very much, that is to say, he was told to eat a lot of fresh vegetables and meat and eggs. .

(9)耿某,男82岁,浑身无力、耳鸣、腿软、不思饮食,苔白湿腻,脉滑涩。诊断因为营养过剩而脾实不运,导致系列病变,服用本发明所述中药组合物汤剂一个半月,随访说,腿有劲,上五楼都不喘气,耳不鸣,精神好,反应快,自说要活到100岁。嘱咐其再服一个月以后,每年服两个月,清理五脏,保持健康。(9) Geng X, an 82-year-old male, suffered from general weakness, tinnitus, weak legs, no desire to eat, white and wet greasy fur, slippery and astringent pulse. It was diagnosed that the spleen was not moving because of overnutrition, leading to a series of diseases. After taking the Chinese medicine composition decoction of the present invention for one and a half months, the follow-up said that the legs were strong, and the fifth floor was not panting, the ears were not ringing, the spirit was good, and the reaction was fast. Said to live to be 100 years old. Advise it to take one month later, take two months every year, clean the five internal organs, keep healthy.

总之,本发明所述中药组合物不论从理论还是从实践上说,其疗效都是肯定的。当今社会,吃不饱的情况基本不存在,创业的一代,过去困难时期吃糠咽菜,如今生活水平提高,便猛吃猛喝,许多病来的又快又突然;第二代想吃什么有什么,不加节制,小胖墩到处都是,加上玩电脑和不锻炼,再加上空气、食品的污染,“富贵病”几乎人人都或多或少的患有,因此造成营养过剩,五脏不运,杂病怪病百出。本发明所述的中药组合物应时而创,重在清理五脏,治疗与预防相结合,犹如汽车实时保养,长期服用无毒副作用。In a word, the curative effect of the traditional Chinese medicine composition of the present invention is affirmative both in theory and in practice. In today's society, there is basically no shortage of food. The entrepreneurial generation used to eat bran and swallow vegetables in difficult times. Now that their living standards have improved, they eat and drink too much, and many diseases come quickly and suddenly. What do the second generation want to eat? What's the matter, without restraint, little chubby guys are everywhere, plus playing computer and not exercising, plus air and food pollution, almost everyone suffers from the "rich man's disease" more or less, resulting in overnutrition, The five internal organs are out of luck, miscellaneous diseases are full of strange diseases. The traditional Chinese medicine composition of the present invention is created in accordance with the times, focusing on cleaning the five internal organs, combining treatment and prevention, just like the real-time maintenance of a car, long-term use without toxic and side effects.

以上实施例的说明只是用于帮助理解本发明,使本领域专业技术人员能够实现或使用本发明,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。The descriptions of the above embodiments are only used to help understand the present invention, so that those skilled in the art can implement or use the present invention, and are not intended to limit the present invention. Any modifications made, equivalent Replacement, improvement, etc. should all be included within the protection scope of the present invention.

Claims (6)

1. a Chinese medicine composition, is characterized in that, is made up of the crude drug of following weight portion:
Rhizoma Atractylodis 8-15, Semen Arecae 10-20, Cortex Magnoliae Officinalis 8-15, Fructus Aurantii Immaturus 8-15, Rhizoma Acori Graminei 8-12, Radix Platycodonis 8-15, Radix Peucedani 8-15, Poria 8-15, Fructus Perillae 8-12, Bulbus Fritillariae Uninbracteatae 8-12, Rhizoma Sparganii 10-15, Rhizoma Curcumae 10-15, Radix Scutellariae 10-15, Flos Lonicerae 15-20, Herba Patriniae 10-15, Semen Raphani 10-15, Radix Et Rhizoma Rhei 6-10, Cortex Moutan 10-15, Fructus Crataegi 10-15.
2. Chinese medicine composition according to claim 1, is characterized in that, is made up of the crude drug of following weight portion:
Rhizoma Atractylodis 10, Semen Arecae 12, Cortex Magnoliae Officinalis 10, Fructus Aurantii Immaturus 10, Rhizoma Acori Graminei 10, Radix Platycodonis 12, Radix Peucedani 10, Poria 12, Fructus Perillae 10, Bulbus Fritillariae Uninbracteatae 10, Rhizoma Sparganii 12, Rhizoma Curcumae 12, Radix Scutellariae 12, Flos Lonicerae 18, Herba Patriniae 12, Semen Raphani 12, Radix Et Rhizoma Rhei 8, Cortex Moutan 12, Fructus Crataegi 12.
3. prepare a method for Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that,
According to parts by weight weighting raw materials, by the crude drug mixing weighed up, sterilization, pack, decoct into decoction and take;
Or, take raw material according to parts by weight, after crude drug being cleaned sterilizing, be ground into 200 order-500 object fine powder dress zero capsules;
Or, according to parts by weight weighting raw materials, use Chinese medicine extraction technology to obtain extract, and one or more pharmaceutically acceptable carrier be prepared into useful clinically dosage form.
4. a pharmaceutical preparation, is characterized in that, containing, for example the powder of the Chinese medicine composition described in the arbitrary claim of claim 1 to 2 or extraction extractum in this pharmaceutical preparation.
5. pharmaceutical preparation according to claim 4, is characterized in that, this pharmaceutical preparation is capsule, tablet, oral liquid, granule, syrup, drop pill, the watered pill, honeyed pill, the sustained-release preparation of pro ore; The liquid drugs injection injection of injection, freeze-dried powder, aseptic powder injection, infusion solutions.
6. the Chinese medicine composition described in claim 1 or 2 for the preparation for the treatment of " affluenza " medicine in application, described " affluenza " is because of overnutrition, stop up in the human body that the Various Complex factor of science feed and social life does not cause and block plug fire-toxin, rotten thing, blood stasis, strongly fragrant gas, stool, dyspepsia, expectorant is turbid, wet dirty, and then have impact on the vital organs of the human body and to counteract each other the healthy poised state run, cause unbalance the produced hyperglycemia of health, hypertension, hyperlipidemia, fatty liver, overweight, constipation, loose stool, abdominal distention, gastrointestinal dysfunction, insomnia, soreness of waist and ache in legs, forgetful, sexual impotence, or menoxenia.
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CN101780167A (en) * 2009-01-15 2010-07-21 王峰 Chinese medicine compound for preventing and curing lung diseases and clearing human body toxin and preparation method thereof
CN101829293A (en) * 2010-02-05 2010-09-15 泰一和浦(北京)中医药研究院有限公司 Traditional Chinese medicine composite for treating cough disease and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101780167A (en) * 2009-01-15 2010-07-21 王峰 Chinese medicine compound for preventing and curing lung diseases and clearing human body toxin and preparation method thereof
CN101829293A (en) * 2010-02-05 2010-09-15 泰一和浦(北京)中医药研究院有限公司 Traditional Chinese medicine composite for treating cough disease and preparation method thereof

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