CN103539715A - Preparation method of methionine chelate zinc - Google Patents
Preparation method of methionine chelate zinc Download PDFInfo
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- CN103539715A CN103539715A CN201210239607.6A CN201210239607A CN103539715A CN 103539715 A CN103539715 A CN 103539715A CN 201210239607 A CN201210239607 A CN 201210239607A CN 103539715 A CN103539715 A CN 103539715A
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- Prior art keywords
- methionine
- zinc
- feed
- chelated zinc
- preparation
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- 229930182817 methionine Natural products 0.000 title claims abstract description 45
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title abstract description 21
- 239000011701 zinc Substances 0.000 title abstract description 21
- 229910052725 zinc Inorganic materials 0.000 title abstract description 21
- 239000013522 chelant Substances 0.000 title abstract 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 24
- 238000006243 chemical reaction Methods 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 14
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims abstract description 13
- 229960001763 zinc sulfate Drugs 0.000 claims abstract description 13
- 229910000368 zinc sulfate Inorganic materials 0.000 claims abstract description 13
- 238000001035 drying Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 229940038879 chelated zinc Drugs 0.000 claims description 31
- 238000003756 stirring Methods 0.000 claims description 15
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims description 14
- 239000000376 reactant Substances 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 238000010792 warming Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 7
- 230000012010 growth Effects 0.000 abstract description 5
- 102000004169 proteins and genes Human genes 0.000 abstract description 5
- 102000004190 Enzymes Human genes 0.000 abstract description 4
- 108090000790 Enzymes Proteins 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 108090000623 proteins and genes Proteins 0.000 abstract description 4
- 235000019629 palatability Nutrition 0.000 abstract description 3
- 235000013343 vitamin Nutrition 0.000 abstract description 3
- 239000011782 vitamin Substances 0.000 abstract description 3
- 229940088594 vitamin Drugs 0.000 abstract description 3
- 229930003231 vitamin Natural products 0.000 abstract description 3
- 239000003674 animal food additive Substances 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 239000010865 sewage Substances 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000002912 waste gas Substances 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000011573 trace mineral Substances 0.000 description 3
- 235000013619 trace mineral Nutrition 0.000 description 3
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 235000009967 Erodium cicutarium Nutrition 0.000 description 1
- 240000003759 Erodium cicutarium Species 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 206010048259 Zinc deficiency Diseases 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000005305 organ development Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- -1 phytate anion Chemical class 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
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- Fodder In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention discloses a preparation method of methionine chelate zinc, and the product belongs to the field of feed additives. The methionine chelate zinc is produced in batches by utilizing methionine, zinc sulfate, 70% of water and 10% of sodium hydroxide aqueous solution as raw materials and utilizing a chemical reaction kettle, a centrifugal separator and a drying machine as equipment, the method is simple in process, mild in reaction conditions and free of sewage or waste gas emission, after being added in a feed, the methionine chelate zinc product can ensure good palatability, high absorption rate and easy transfer for the prepared feed, reinforce the activity of enzymes in an animal and improve the utilization rates of protein, fat and vitamins so as to improve the growth performance and the immunity of the animal, and when in use, the methionine chelate zinc is doped in an animal feed according to a proportion of 0.03% of weight of the feed.
Description
Technical field
The invention belongs to feed additive field, relate in particular to a kind of preparation method of methionine chelated zinc.
Background technology
Trace element zinc is one of requisite nutrient substance in growth of animal process, zinc to the effect of animal is: 1. zinc is the moiety of a lot of enzymes, also be the activator of some enzyme, the metabolism of zinc involved in sugar, participation red corpuscle transports in the oxygen enzyme relevant with carbonic acid gas also zinc; 2. zinc and nucleic acid and protein synthesizes and the growth of cell is had to close relationship; 3. zinc is the key element that promotes sexual organ development; 4. zinc can promote wound healing: to wound or the very dark openning of crowfoot cracks, surgery often adopts ointment of zinc oxide, and result for the treatment of is better; 5. zinc can maintain normal scotopia ability; 6. zinc can keep the normal sense of taste and appetite; 7. zinc can improve immunological competence, and scarce zinc can cause Immune Dysfunction.So important effect of zinc, therefore in animal-feed, add zinc, initial zinc is to add in feed with the form of zinc sulfate, although zinc sulfate is water-soluble fine, but in animal digestive tract easily with feed in common phytate anion, oxalic acid negatively charged ion through the biochemical reaction form in animal body, form the zinc salt that corresponding solubleness is very little, difficult by intestinal absorption.Development along with feed industry, utilizing amino acid and trace element to carry out amino-acid trace element chelate-methionine chelated zinc that chelating obtains is developed, its feature be stablize, efficiently, toxicity is little, in enteron aisle, be easy to digest and assimilate, be conducive to growth of animal, can prevent and treat zinc deficiency, improve the immunity of organisms of animal, and useful for utilizing of nutrition composition in feed, also have the effect of high-protein agent concurrently.Methionine chelated zinc, its structure absorbs the natural form of zinc close to animal body, it is again the intermediate material of synthetic proteins process in animal body, and the stability constant of methionine chelated zinc is moderate, make animal absorption rate than the fast 2-3 of zinc sulfate doubly, and can save many biological processes, and save physical consumption, improve efficiency of feed utilization.The present invention be take methionine(Met) and zinc sulfate and is prepared methionine chelated zinc as main raw material, after product methionine chelated zinc adds in feed, can make the feed good palatability of preparation, specific absorption is high, easily transhipment, can strengthen the activity of animal body endoenzyme, improve the utilization ratio of protein, fat and VITAMIN, thereby improve growth performance and the immunological competence of animal.
Summary of the invention
The problem that the present invention mainly solves is to provide that a kind of to take methionine(Met) and zinc sulfate be raw material, take chemical reaction kettle, separating centrifuge, dryer is the method for equipment batch production methionine chelated zinc, the method technique is simple, reaction conditions is gentle, without sewage exhaust gas emission, good quality of product, methionine chelated zinc adds in feed by after animal edible, can strengthen the activity of animal body endoenzyme, improve immunizing power.Producing the raw material that this product uses has: methionine(Met) 19%-20%, zinc sulfate 10%-11%, water 70%, 10% aqueous sodium hydroxide solution are appropriate.
The present invention can be achieved through the following technical solutions:
Produce a method for methionine chelated zinc in batches, it is characterized in that being formed by following steps:
(1) in reactor, first add the water of formula ratio, add successively formula ratio methionine(Met) and zinc sulfate, warming while stirring is to 35-37 ℃ again, uses 10% aqueous sodium hydroxide solution to control pH value all the time between 7.0-7.2, after stirring reaction 0.8-1 hour, stop stirring, chelatropic reaction finishes.
(2) reactant is sent into separating centrifuge separation, removing the solid obtaining after moisture is methionine chelated zinc, now methionine chelated zinc is sent into drying machine sealing and is dried, and after then oven dry thing being pulverized, is packaged to be finished product.
(3) using method of methionine chelated zinc is: the ratio in feed weight 0.03% is mixed in animal-feed.
Chelating temperature described in above-mentioned steps (1) is 36 ℃;
The drying temperature of the drying machine described in above-mentioned steps (2) is 90 ℃-100 ℃, and drying time is 10 hours.
The invention has the beneficial effects as follows: the production method that a kind of methionine chelated zinc is provided, this production method have technique simple, use general-purpose equipment, three-waste free discharge, without high-temperature high-voltage reaction, be easy to the series of advantages such as production operation, good product quality, after product methionine chelated zinc adds in feed, can make the feed good palatability of preparation, specific absorption is high, easily transhipment, can strengthen the activity of animal body endoenzyme, improve the utilization ratio of protein, fat and VITAMIN, thereby improve growth performance and the immunological competence of animal.
Embodiment
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
In reactor, first add that to account for total amount be 70% water, add successively again that to account for total amount be 19% methionine(Met) and to account for total amount be 11% zinc sulfate, warming while stirring is to 35-37 ℃, the aqueous sodium hydroxide solution of use 10% is controlled pH value all the time between 7.0-7.2, after stirring reaction 0.8-1 hour, stop stirring, chelatropic reaction finishes; Reactant is sent into separating centrifuge separation, and removing the solid obtaining after moisture is methionine chelated zinc, now methionine chelated zinc is sent into drying machine sealing and is dried, and after then oven dry thing being pulverized, is packaged to be finished product; The using method of methionine chelated zinc is: the ratio in feed weight 0.03% is mixed in animal-feed.
Embodiment 2
In reactor, first add that to account for total amount be 70% water, add successively again that to account for total amount be 19.5% methionine(Met) and to account for total amount be 10.5% zinc sulfate, warming while stirring is to 35-37 ℃, the aqueous sodium hydroxide solution of use 10% is controlled pH value all the time between 7.0-7.2, after stirring reaction 0.8-1 hour, stop stirring, chelatropic reaction finishes; Reactant is sent into separating centrifuge separation, and removing the solid obtaining after moisture is methionine chelated zinc, now methionine chelated zinc is sent into drying machine sealing and is dried, and after then oven dry thing being pulverized, is packaged to be finished product; The using method of methionine chelated zinc is: the ratio in feed weight 0.03% is mixed in animal-feed.
Embodiment 3
In reactor, first add that to account for total amount be 70% water, add successively again that to account for total amount be 20% methionine(Met) and to account for total amount be 10% zinc sulfate, warming while stirring is to 35-37 ℃, the aqueous sodium hydroxide solution of use 10% is controlled pH value all the time between 7.0-7.2, after stirring reaction 0.8-1 hour, stop stirring, chelatropic reaction finishes; Reactant is sent into separating centrifuge separation, and removing the solid obtaining after moisture is methionine chelated zinc, now methionine chelated zinc is sent into drying machine sealing and is dried, and after then oven dry thing being pulverized, is packaged to be finished product; The using method of methionine chelated zinc is: the ratio in feed weight 0.03% is mixed in animal-feed.
Claims (4)
1. a preparation method for methionine chelated zinc, the proportioning raw materials of use is: methionine(Met) 19%-20%, zinc sulfate 10%-11%, water 70%, 10% aqueous sodium hydroxide solution are appropriate; It is characterized in that: step (1) first adds the water of formula ratio in reactor, add successively again formula ratio methionine(Met) and zinc sulfate, warming while stirring is to 35-37 ℃, the aqueous sodium hydroxide solution of use 10% is controlled pH value all the time between 7.0-7.2, after stirring reaction 0.8-1 hour, stop stirring, chelatropic reaction finishes; Step (2) is sent reactant into separating centrifuge separation, and removing the solid obtaining after moisture is methionine chelated zinc, now methionine chelated zinc is sent into drying machine sealing and is dried, and after then oven dry thing being pulverized, is packaged to be finished product.
2. the preparation method of a kind of methionine chelated zinc according to claim 1, the feature of its step (1) is: described chelating temperature is 36 ℃.
3. the preparation method of a kind of methionine chelated zinc according to claim 1, the feature of its step (2) is: the drying temperature of described drying machine is 90 ℃-100 ℃, and drying time is 10 hours.
4. the preparation method of a kind of methionine chelated zinc according to claim 1, the using method of methionine chelated zinc is: the ratio in feed weight 0.03% is mixed in animal-feed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210239607.6A CN103539715A (en) | 2012-07-12 | 2012-07-12 | Preparation method of methionine chelate zinc |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210239607.6A CN103539715A (en) | 2012-07-12 | 2012-07-12 | Preparation method of methionine chelate zinc |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103539715A true CN103539715A (en) | 2014-01-29 |
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| CN201210239607.6A Pending CN103539715A (en) | 2012-07-12 | 2012-07-12 | Preparation method of methionine chelate zinc |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105708857A (en) * | 2016-03-15 | 2016-06-29 | 济南大东农生物技术有限公司 | Nano silver complex iodine compound antiviral preparation |
| CN106928085A (en) * | 2017-01-22 | 2017-07-07 | 陕西师范大学 | A kind of L theanine chelates of zinc and preparation method and tea beverage and preparation method containing the chelate |
| CN108185143A (en) * | 2018-03-16 | 2018-06-22 | 中国科学院亚热带农业生态研究所 | A kind of ruminant domestic animal mixed feed and preparation method based on Methionine Chelated Zinc |
-
2012
- 2012-07-12 CN CN201210239607.6A patent/CN103539715A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105708857A (en) * | 2016-03-15 | 2016-06-29 | 济南大东农生物技术有限公司 | Nano silver complex iodine compound antiviral preparation |
| CN106928085A (en) * | 2017-01-22 | 2017-07-07 | 陕西师范大学 | A kind of L theanine chelates of zinc and preparation method and tea beverage and preparation method containing the chelate |
| CN108185143A (en) * | 2018-03-16 | 2018-06-22 | 中国科学院亚热带农业生态研究所 | A kind of ruminant domestic animal mixed feed and preparation method based on Methionine Chelated Zinc |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140129 |