CN103520076B - Compound Chinese medicine extract is preparing the application in oral cavity nursing health products - Google Patents
Compound Chinese medicine extract is preparing the application in oral cavity nursing health products Download PDFInfo
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- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses compound Chinese medicine extract and prepare the application in oral cavity nursing health products, relate to oral care techniques field, namely in the technique preparing oral care product, the ancillary drug raw material that Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, these four kinds of Chinese medicine extract of Fructus Zanthoxyli extract act on as anti-dentin hypersensitiveness is added in oral cavity nursing health products, these four kinds of Chinese medicine extract not only use safety in the oral care implements such as toothpaste, collutory, dentifrice, throat lozenge, chewing gum, and there is the effect of obvious anti-dentin hypersensitiveness.
Description
Technical field
The present invention relates to oral care techniques field, especially a kind of oral cavity nursing health products with anti-dentin hypersensitiveness.
Background technology
The oral care product that people commonly use is toothpaste, collutory, dentifrice etc. mainly, and its basic function is exactly cleaning teeth, and protection gingiva, safeguards the hygiene and health in oral cavity.Along with the raising of people's living standard, the health care consciousness of consumer constantly strengthens, more requirement be it is also proposed to oral care product, the requirement of people to toothpaste and collutory also add effect that some can assist prevention oral disease except having this basic function that cleans the teeth, therefore, toothpaste in the market and collutory almost all add the functional component for the various oral disease of control, therefore the product that oral care product both domestic and external has a various functional type becomes the market mainstream, is mostly wherein to add western medicine composition to realize.
But along with the development of economy, along with day by day manifesting of the problem such as environmental pollution, ecological disturbance, the safety of consumer to product is more and more paid close attention to, thus more and more advocates natural and safe product.Interpolation effectively can prevent and treat the oral care product of various oral disease Chinese herbal medicine, little with its toxic and side effects, and green, environmental protection, safety high and be doubly subject to the favor of people, on market, the consumption demand of this series products is in continuous growth.In addition, along with the development of modernization of Chinese medicine technology, have also been obtained fine development to the method that Chinese medicine study of active components utilizes, this prevents oral disease to provide good technical support for oral care product utilizes active ingredient of Chinese herbs to assist.
Dentin hypersensitiveness is the dentin part that tooth exposes when being subject to machinery, chemistry or thermal stimulus, and producing the symptom of a kind of special acid, " soft ", pain, is the oral disease caused by many reasons.Desensitizer is in the market the chemical desensitizer such as strontium salt, potassium salt, oxalates, fluoride, silver nitrate mainly, and the non-chemosynthesis of these chemical desensitizeies, life-time service deposits insalubrity in vivo.Chinese herbal medicine desensitization composition, toxic and side effects more safer than present most of chemical desensitizer and zest less, not easily produce toleration.Therefore, anti-for vegetable Chinese herbal medicine dentin hypersensitiveness composition is added in oral care product to the direction having become people's research.
Summary of the invention
The problem that the present invention solves is to provide compound Chinese medicine extract and is preparing the application scheme in oral cavity nursing health products, and this oral cavity nursing health products has the effect of obvious anti-dentin hypersensitiveness.
Compound Chinese medicine extract of the present invention is exactly joined in the oral cavity nursing health products such as toothpaste, collutory, dentifrice, throat lozenge, chewing gum by the ancillary drug raw material that compound Chinese medicine extract acts on as anti-dentin hypersensitiveness in the technique preparing oral cavity nursing health products preparing the application scheme in oral cavity nursing health products, and described compound Chinese medicine extract is Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract.
In technique scheme, the ancillary drug raw material that Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract act on as anti-dentin hypersensitiveness joins in toothpaste, the percentage by weight of these four kinds of extracts in total mastic of toothpaste is 2-15%, and described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
In technique scheme, the ancillary drug raw material that described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract act on as anti-dentin hypersensitiveness joins in collutory, the percentage by weight of these four kinds of extracts in collutory raw material is 2-15%, and described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
In technique scheme, the ancillary drug raw material that described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract act on as anti-dentin hypersensitiveness joins in dentifrice, the percentage by weight of these four kinds of extracts in dentifrice raw material is 2-15%, and described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
In technique scheme, the ancillary drug raw material that described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract act on as anti-dentin hypersensitiveness joins in throat lozenge, the percentage by weight of these four kinds of extracts in throat lozenge raw material is 2-15%, and described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
In technique scheme, the ancillary drug raw material that described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract act on as anti-dentin hypersensitiveness joins in chewing gum, the percentage by weight of these four kinds of extracts in chewing-gum material is 2-15%, and described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
The said Radix Zanthoxyli of the present invention is the dry root of rutaceae Radix Zanthoxyli Zanthoxylumnitidum (Roxb.) DC..Nature and flavor are bitter, pungent, flat; Slightly poisonous. return liver, stomach warp.Function is blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, dispelling wind and removing obstruction in the collateral, removing toxic substances and promoting subsidence of swelling.For injury from falling down, stomachache, toothache, rheumatic arthralgia, venom; Externally treating burns and scalds.
Galla Chinensis of the present invention is the insect gall on Anacardiaceae plant Fructus rhois chinensis RhuschishMill., potanin sumac RhuspotaniniiMaxim. or red bulging poplar RhuspunjabensisStew.var.sinica (Diels) Rehd.etWils. leaf, primarily of melaphis chinensis Baker Melaphisc/u.Bell) Baker is parasitic and formed, nature and flavor are sour, puckery, cold.Return lung, large intestine, kidney channel.Function is pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating, hemostasis, removing dampness sore.For chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, spontaneous sweating, quenches one's thirst, hemorrhoidal bleeding of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.
Rhizoma Corydalis of the present invention is the dry tuber of papaveraceae plant corydalis CorydalisyanhusuoW.T.Wang.Nature and flavor are pungent, bitter, temperature.Return liver, spleen channel.Function for invigorating blood circulation, circulation of qi promoting, pain relieving.For the breast side of body, epigastric pain, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, resistance of becoming silted up puerperal, tumbling and swelling.
Pericarpium Zanthoxyli of the present invention is the dry mature skin of rutaceae Capsicum annuum L. Zanthoxylumschini foliumSieb.et Zucc.EttZanthoxylumbungeanumMaxim..Nature and flavor are pungent, temperature.Return spleen, stomach, kidney channel, there is warming middle-JIAO to relieve pain, killing parasites for relieving itching, for coldness and pain in the epigastrium, the effects such as vomiting is had loose bowels, abdominal pain due to worm stagnation; Cure mainly external treatment eczema, pudendal pruritus etc.
Mouth care health product of the present invention add the raw material not only use safety of compound Chinese medicine extract as natural plant active component in preparation process, and have the effect of obvious anti-dentin hypersensitiveness.
Be use with the form of compound Chinese medicine extract in the present invention, its extracting method is by broken for herbal mixture granulating, extracts 3 hours, extract 3 times, then extracting solution concentrating under reduced pressure is dried to powdery with the alcohol heating reflux of 10 times amount.The extracting method of herbal mixture is not limited to said method, and the additive method such as supercritical extraction, ultrasonic extraction also can be adopted to extract.
The content of the herbal mixture described in the present invention is all the pure extract powder of 100% for active component, but is not limited to pure extract powder, also can be other form such as extracting solution or extractum.In time being applied to oral care product with other forms as extracting solution, the addition in formula should be converted to the amount of pure form of extract disclosed in the present invention.
The present invention confirms through pharmacological evaluation, and the oral care product of herbal mixture has significant anti-dentine hypersensitivity effect, can be used for preparing oral cavity composition.
The present invention carries out clinical trial checking to the toothpaste containing herbal mixture.Experimental result shows, this herbal mixture toothpaste effectively can treat the dental hypersensitiveness of patient, and overall clinical efficacy rate is 82%, has the effect of obvious anti-dentin hypersensitiveness.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.In following each embodiment, involved percentage ratio except as otherwise noted, is all calculate by weight percentage.
Embodiment 1 ~ 5: Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are as the application of compound Chinese medicine extract in toothpaste, and Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
Toothpaste constitutive material in embodiment 1 to embodiment 5 and weight percent content are as following table 1:
In the present embodiment 3, lotion of toothpaste adopts the one-step method cream production technology of conventional medicine toothpaste to make: in temporary cylinder, drop into the liquid material such as pure water, sorbitol, compound Chinese medicine extract measured; In pre-dispersed still, drop into the calcite in powder, saccharin sodium, carboxycellulose sodium, sodium lauryl sulphate, the nipalgin that measure mix the powders such as ester sodium, carry out pre-dispersed, mixing; Open cream still vacuum pump processed and suck above-mentioned liquid material; Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, after 30 minutes, drop into essence, close colloid mill, agitator, scraper successively after 10 minutes, vacuum breaker, stop vacuum pump, make after sampling detection is qualified.
The production technology of the lotion of toothpaste of other embodiment above-mentioned is with reference to embodiment 3.
Embodiment 6 ~ 10: Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are as the application of compound Chinese medicine extract in collutory, and Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
Collutory constitutive material in embodiment 6 to embodiment 10 and weight percent content are as following table 2:
In the present embodiment 8, first compound Chinese medicine extract, nipalgin mixed ester sodium are added stirring and dissolving in edible ethanol and is placed in temporary pot, sorbitol, deionization, castor oil hydrogenated-40 are added in agitated kettle and stirs 10 minutes, alcoholic solution in temporary pot is added in agitated kettle and stir 10 minutes, finally add essence and stir 5 minutes, stop stirring, make after sampling detection is qualified.
The collutory production technology of other embodiment above-mentioned is with reference to embodiment 8.
Embodiment 11 ~ 15: Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are applied in dentifrice as compound Chinese medicine extract, Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
Dentifrice constitutive material in embodiment 11 to embodiment 15 and weight percent content are as following table 3:
In the present embodiment 13; natural whiting, sodium carboxymethyl cellulose, sodium lauryl sulphate, saccharin sodium are added after weighing up by formula consumption in mixing agitator to stir and add compound Chinese medicine extract after 20 minutes and stir 10 minutes; finally add essence, sorbitol stir after 20 minutes shut down, sampling detect qualified after make.
The production technology of the dentifrice of other embodiment above-mentioned is with reference to embodiment 11.
Embodiment 16 ~ 20: multiple Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are as the application of compound Chinese medicine extract in throat lozenge, and Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
Throat lozenge constitutive material in embodiment 16 to embodiment 20 and weight percent content are as following table 4:
The preparation technology of the present embodiment 16 ~ 20 adopts existing throat lozenge production technology.
Embodiment 21 ~ 25: multiple Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are as the application of compound Chinese medicine extract in chewing gum, and Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
Chewing gum constitutive material in embodiment 21 to embodiment 25 and weight percent content are as following table 5:
The preparation technology of the present embodiment 21 ~ 25 adopts the production technology of existing chewing gum.
Clinical experiment part:
Dentin hypersensitiveness patient is used and treats containing compound Chinese medicine extract toothpaste sample, process of the test and result as follows:
1, case selection: have excessive tooth to wear away in Outpatient Service Stomatology patient, cervical region wedge shaped defect, the Root exposnre of gingival atrophy, but without dental caries, without hiddenly splitting, hurtless measure, without gingivitis and periodontitis person, through visit examine, air gun blowing, cold water is examined and is defined as dental hypersensitiveness, totally 25 example, 77 teeth, wherein man 14 example, female 11 example, age 24-74 year.
2, sensitivity assessment: adopt Ishikawa to stop two standards of grading, with the water of 10 degree as cold stimulation, coordinates local probe inspection and blows over quick district with air gun, according to the reaction of patient to this stimulation, dental hypersensitiveness is divided into 4 degree: 0 degree without uncomfortable; 1 degree is slightly not suitable with or pain; 2 degree of moderate pains; 3 degree of severe pain and continue.
3, method: patient uses containing compound Chinese medicine extract toothpaste sample 2-3 times/day, each 3-5 minute, continues to use 2-3 week, (centre does not use other Claritins and toothpaste).
4, therapeutic evaluation: 1.-1 take a turn for the better; 2. 0 without changing; 3.+1 increases the weight of
Effective percentage=take a turn for the better/treat total tooth number × 100%.
5, result: 25 routine patients totally 77 teeth in use, containing after compound Chinese medicine extract toothpaste sample 2-3 week, effective percentage=take a turn for the better/treat total tooth number × 100%=82%.
Dental hypersensitiveness is a kind of common frdquently encountered disease, and be more common in men and women patient above middle age, male is more than women.Common cause is the defect due to hard tooth tissue, and as wearing and tearing, acid corrosion, wedge shaped defect etc. cause.Experimental result shows, be 82% containing compound Chinese medicine extract toothpaste sample group total effective rate in the clinical trial of the anti-dental hypersensitiveness for the treatment of, result of the test patient comparatively satisfaction, has the effect of obvious anti-dentin hypersensitiveness.
Claims (5)
1. compound Chinese medicine extract is preparing the application in toothpaste technique, namely add in toothpaste using the ancillary drug raw material that compound Chinese medicine extract acts on as anti-dentin hypersensitiveness preparing in toothpaste technique, described compound Chinese medicine extract is Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract; Described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, the Fructus Zanthoxyli extract percentage by weight in total mastic of toothpaste is 2-15%, and described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
2. compound Chinese medicine extract is preparing the application in collutory technique, namely add in collutory using the ancillary drug raw material that compound Chinese medicine extract acts on as anti-dentin hypersensitiveness preparing in collutory technique, described compound Chinese medicine extract is Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract; Described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, the Fructus Zanthoxyli extract percentage by weight in total mastic of collutory is 2-15%, and described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
3. compound Chinese medicine extract is preparing the application in dentifrice technique, namely add in dentifrice using the ancillary drug raw material that compound Chinese medicine extract acts on as anti-dentin hypersensitiveness preparing in dentifrice technique, described compound Chinese medicine extract is Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract; Described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, the Fructus Zanthoxyli extract percentage by weight in total mastic of dentifrice is 2-15%, and described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
4. compound Chinese medicine extract is preparing the application in throat lozenge technique, namely add in throat lozenge using the ancillary drug raw material that compound Chinese medicine extract acts on as anti-dentin hypersensitiveness preparing in throat lozenge technique, described compound Chinese medicine extract is Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract; Described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, the Fructus Zanthoxyli extract percentage by weight in total mastic of throat lozenge is 2-15%, and described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
5. compound Chinese medicine extract is preparing the application in chewing gum technique, namely add in chewing gum using the ancillary drug raw material that compound Chinese medicine extract acts on as anti-dentin hypersensitiveness preparing in chewing gum technique, described compound Chinese medicine extract is Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract; Described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, the Fructus Zanthoxyli extract percentage by weight in total mastic of chewing gum is 2-15%, and described Radix Zanthoxyli extract, Galla Chinensis extract, Rhizoma Corydalis extract, Fructus Zanthoxyli extract are than being 0.5:2:2:1.
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| CN113499374A (en) * | 2021-09-01 | 2021-10-15 | 青岛市口腔医院 | Traditional Chinese medicine composition for treating dentin hypersensitivity and toothpaste |
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