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CN115770205A - Oral cavity cleaning liquid and preparation method and application thereof - Google Patents

Oral cavity cleaning liquid and preparation method and application thereof Download PDF

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Publication number
CN115770205A
CN115770205A CN202111034757.9A CN202111034757A CN115770205A CN 115770205 A CN115770205 A CN 115770205A CN 202111034757 A CN202111034757 A CN 202111034757A CN 115770205 A CN115770205 A CN 115770205A
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China
Prior art keywords
parts
solution
extracting solution
oral
extract
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Pending
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CN202111034757.9A
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Chinese (zh)
Inventor
朱江涛
向文林
许立
陈可夫
向文明
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Wuhan Zdeer Technology Co Ltd
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Wuhan Zdeer Technology Co Ltd
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Priority to CN202111034757.9A priority Critical patent/CN115770205A/en
Publication of CN115770205A publication Critical patent/CN115770205A/en
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses an oral cleaning solution, a preparation method and an application thereof, belonging to the field of oral treatment, wherein the oral cleaning solution comprises the following raw materials in parts by weight: the oral cavity cleaning liquid comprises, by weight, 0.1-2 parts of edible sodium chloride, 0.1-5 parts of plantain herb extracting solution, 0.1-2.5 parts of rhizoma corydalis extracting solution, 0.1-7.5 parts of honeysuckle extracting solution, 0.1-5 parts of mint extracting solution, 0.1-3 parts of sweetening agent and 50-75 parts of deionized water.

Description

Oral cavity cleaning liquid and preparation method and application thereof
Technical Field
The invention relates to the field of oral treatment, in particular to an oral cleaning fluid and a preparation method and application thereof.
Background
The oral cavity is the initial part of the digestive system, the front wall of the oral cavity is an upper lip and a lower lip, the side wall of the oral cavity is a cheek, the upper wall is a palate, the lower wall of the oral cavity is an oral floor, the oral cavity is led to the outside through a cleft mouth surrounded by the lips forwards, and is communicated with the pharynx through a pharynx gorge backwards, the oral cavity can be divided into an oral cavity vestibule and an inherent oral cavity, the former is a gap between the upper lip and the lower lip and the cheek, an upper dental arch and a lower dental arch and gum, the latter is a space surrounded by the upper dental arch, the lower dental arch and the gum, the top of the oral cavity is the palate, and the bottom of the oral cavity is composed of mucous membranes, muscles and skin;
the most common oral diseases are diseases of the tissues of the tooth body, such as dental caries, tooth trauma or pulpitis, periapical periodontitis and the like, and also diseases of supporting tissues around the tooth, such as tooth loosening caused by gingival recession, chronic periodontitis or pericoronitis of wisdom tooth, periodontal abscess and the like, and are also rare, but once serious mucosal diseases occur, such as lichen planus, leukoplakia or other tumors and the like, the oral diseases are also possible to be glandular diseases, because the oral cavity has more glands, sublingual glands, sublabial glands or parotid, inflammation or tumors can occur.
Tooth brushing is an important method for keeping oral hygiene, and tooth brushing is a good hygiene habit every day, but when a wound appears in the oral cavity, tooth brushing and mouth rinsing are often accompanied by bleeding and pain, infection is easily caused at an oral window, and disinfection treatment needs to be carried out in time.
Disclosure of Invention
The invention aims to solve the technical problem that most oral cleaning solutions use components such as hydrogen peroxide solution, sodium bicarbonate solution, sodium chloride injection and the like, so that oral mucosa is damaged, and provides an oral cleaning solution and a preparation method and application thereof, so as to solve the problems.
In order to achieve the purpose, the invention provides the following technical scheme: an oral cleaning solution comprises the following raw materials in parts by weight: 0.1-2 parts of edible sodium chloride, 0.1-5 parts of plantain herb extract, 0.1-2.5 parts of rhizoma corydalis extract, 0.1-7.5 parts of honeysuckle extract, 0.1-5 parts of mint extract, 0.1-3 parts of sweetening agent and 50-75 parts of deionized water.
The edible sodium chloride is generally used as 0.9 percent normal saline, aiming at establishing a hypertonic environment at the local part of the oral cavity, being not beneficial to the growth of bacteria and playing a role in preventing the growth of the bacteria;
the plantain herb can be used for hemostasis, has the functions of clearing heat and promoting urination, has the functions of reducing phlegm, cooling blood and detoxifying, and is used for treating hematemesis, nosebleed and carbuncle sore pyogenic infections;
the rhizoma corydalis can be widely applied to symptoms such as pain of all parts of the whole body caused by blood stasis and qi stagnation, can activate blood and promote qi circulation, has good pain relieving effect, and can be widely applied to the pain of all parts of the whole body caused by blood stasis and qi stagnation;
the honeysuckle extract and some chemical components contained in the honeysuckle extract have various pharmacological effects, mainly comprise anti-inflammatory, antibacterial, antiviral, antioxidant and the like, and have anti-inflammatory and antibacterial effects;
the mint has the main effects of dispelling wind and heat, detoxifying and promoting eruption, clearing throat, soothing liver and regulating qi.
Further, the oral cavity cleaning liquid comprises the following raw materials in parts by weight: 2 parts of edible sodium chloride, 5 parts of plantain herb extracting solution, 2.5 parts of rhizoma corydalis extracting solution, 5.5 parts of honeysuckle extracting solution, 3 parts of mint extracting solution, 2 parts of sweetening agent and 75 parts of deionized water.
Further, the oral cavity cleaning liquid comprises the following raw materials in parts by weight: 1 part of edible sodium chloride, 2 parts of plantain herb extracting solution, 1 part of rhizoma corydalis extracting solution, 7.5 parts of honeysuckle extracting solution, 5 parts of mint extracting solution, 2 parts of sweetening agent and 70 parts of deionized water.
Further, the sweetener comprises any one or more of xylitol, sweetener, acesulfame potassium, stevioside, alitame or sodium cyclamate.
Further, the plantain herb extracting solution, the corydalis tuber extracting solution and the honeysuckle extracting solution are respectively extracted by adopting a steam distillation method.
The steam distillation method is the most common method for extracting the plant natural perfume, the technology in the aspects of flow, equipment, operation and the like is mature, the cost is low, the yield is high, the equipment and the operation are simple, and the method is divided into three forms: distillation in water, distillation in water and water-gas distillation, and any distillation method can be used.
Further, the oral cleaning solution is applied to treating oral diseases.
A preparation method of an oral cleaning solution comprises the following preparation steps:
step 1: mixing herba plantaginis extract, rhizoma corydalis extract, flos Lonicerae extract and sweetener at a certain proportion, stirring thoroughly to obtain stock solution A;
step 2: adding edible sodium chloride into the solution A at a certain proportion, heating for 5-10 min until the edible sodium chloride is completely dissolved, and stirring thoroughly to obtain solution B;
and step 3: adding deionized water into the standby liquid B in proportion, continuously stirring uniformly, and cooling to obtain standby liquid C;
and 4, step 4: mixing the herba Menthae extractive solution and the solution C at a certain proportion, and stirring to obtain the final product.
Further, the warming temperature of the edible sodium chloride added into the standby liquid A in the step 3 is between 30 and 40 ℃.
Compared with the prior art, the invention has the following beneficial effects: the invention relates to an oral cavity cleaning liquid and a preparation method and application thereof, wherein traditional Chinese medicine herbs are used as a base, edible sodium chloride is used for sterilization, plantain herb extracting solution is used for hemostasis, rhizoma corydalis extracting solution is used for relieving pain, honeysuckle flower extracting solution is used for diminishing inflammation, mint extracting solution is used for deodorization, the oral cavity cleaning liquid is non-toxic and harmless, sweet in taste, capable of sterilizing and diminishing inflammation, capable of stopping bleeding and relieving pain, and does not cause excessive stimulation to the environment in an oral cavity.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the embodiment is an oral cavity cleaning solution, which comprises the following raw materials in parts by weight: 2 parts of edible sodium chloride, 5 parts of plantain herb extracting solution, 2.5 parts of rhizoma corydalis extracting solution, 5.5 parts of honeysuckle extracting solution, 3 parts of mint extracting solution, 2 parts of xylitol and 75 parts of deionized water.
In this example, the plantain herb extract, the corydalis tuber extract and the honeysuckle flower extract were extracted by steam distillation, respectively.
A preparation method of an oral cleaning solution comprises the following preparation steps:
step 1: mixing herba plantaginis extract, rhizoma corydalis extract, flos Lonicerae extract and sweetener at a certain proportion, stirring thoroughly to obtain stock solution A;
step 2: adding edible sodium chloride into the standby liquid A according to a certain proportion, heating for 10 minutes until the edible sodium chloride is completely dissolved, and fully stirring to prepare a standby liquid B;
and step 3: adding deionized water into the solution B, stirring, and cooling to obtain solution C;
and 4, step 4: mixing the herba Menthae extract and the solution C at a certain proportion, and stirring to obtain the final product.
Further, the warming temperature of the edible sodium chloride added into the standby liquid A in the step 3 is between 40 ℃.
Example 2:
the embodiment is an oral cleaning solution, which comprises the following raw materials in parts by weight: 1 part of edible sodium chloride, 2 parts of plantain herb extracting solution, 1 part of rhizoma corydalis extracting solution, 7.5 parts of honeysuckle extracting solution, 5 parts of mint extracting solution, 2 parts of xylitol and 70 parts of deionized water.
In this embodiment, the plantain herb extract, the corydalis tuber extract and the honeysuckle flower extract are extracted by steam distillation respectively.
A preparation method of an oral cleaning solution comprises the following preparation steps:
step 1: mixing herba plantaginis extract, rhizoma corydalis extract, flos Lonicerae extract and sweetener at a certain proportion, stirring thoroughly to obtain stock solution A;
step 2: adding edible sodium chloride into the standby liquid A according to a certain proportion, heating for 10 minutes until the edible sodium chloride is completely dissolved, and fully stirring to prepare a standby liquid B;
and step 3: adding deionized water into the standby liquid B in proportion, continuously stirring uniformly, and cooling to obtain standby liquid C;
and 4, step 4: mixing the herba Menthae extractive solution and the solution C at a certain proportion, and stirring to obtain the final product.
Further, the warming temperature of the edible sodium chloride added into the standby liquid A in the step 3 is between 38 ℃.
Example 3:
this example provides an anti-mouth rinse, which differs from example 1 in that no edible sodium chloride is added.
Example 4:
this example provides an anti-mouth rinse, which differs from example 1 in that no psyllium extract is added.
Example 5:
this example provides an anti-oral rinse, which differs from example 1 in that no rhizoma corydalis extract is added.
The oral rinse solutions prepared in examples 1-5 were subjected to the following tests:
2 cases of oral inflammation patients are selected, the oral cleaning solutions prepared in the embodiments 1, 2 and 5 are used respectively, according to the description of the patients, the pain of the patients using the oral cleaning solution prepared in the embodiment 1 disappears obviously, the pain of the patients using the oral cleaning solution prepared in the embodiment 2 is relieved, and the patients using the oral cleaning solution prepared in the embodiment 5 has no change;
bacteriostatic tests were carried out on the oral cleaning solutions prepared in examples 1 to 5, respectively, and the results showed that the oral cleaning solution prepared in example 3 had poor bacteriostatic activity;
the oral cavity rinses prepared in examples 1 to 5 were subjected to hemostasis tests, respectively, and as a result, the oral cavity rinses prepared in example 3 had a low blood coagulation rate.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (8)

1. An oral cleaning solution, characterized in that: the oral cavity cleaning liquid comprises the following raw materials in parts by weight: 0.1-2 parts of edible sodium chloride, 0.1-5 parts of plantain herb extract, 0.1-2.5 parts of rhizoma corydalis extract, 0.1-7.5 parts of honeysuckle extract, 0.1-5 parts of mint extract, 0.1-3 parts of sweetening agent and 50-75 parts of deionized water.
2. The oral cleaning solution according to claim 1, which comprises the following raw materials in parts by weight: 2 parts of edible sodium chloride, 5 parts of plantain herb extracting solution, 2.5 parts of rhizoma corydalis extracting solution, 5.5 parts of honeysuckle extracting solution, 3 parts of mint extracting solution, 2 parts of sweetening agent and 75 parts of deionized water.
3. An oral cleaning solution according to claim 1, wherein: the oral cleaning liquid comprises the following raw materials in parts by weight: 1 part of edible sodium chloride, 2 parts of plantain herb extracting solution, 1 part of rhizoma corydalis extracting solution, 7.5 parts of honeysuckle extracting solution, 5 parts of mint extracting solution, 2 parts of sweetening agent and 70 parts of deionized water.
4. An oral cleaning solution according to claim 1, wherein: the sweetener comprises any one or more of xylitol, sweetener, acesulfame potassium, stevioside, alitame or sodium cyclamate.
5. An oral cleaning solution according to claim 1, wherein: the plantain herb extracting solution, the corydalis tuber extracting solution and the honeysuckle extracting solution are respectively extracted by adopting a steam distillation method.
6. Use of an oral rinse according to any of claims 1 to 5 for the treatment of oral disorders.
7. The preparation method of the oral cleaning liquid is characterized by comprising the following preparation steps:
step 1: mixing herba plantaginis extract, rhizoma corydalis extract, flos Lonicerae extract and sweetener at a certain proportion, stirring thoroughly to obtain stock solution A;
and 2, step: adding edible sodium chloride into the solution A at a certain proportion, heating for 5-10 min until the edible sodium chloride is completely dissolved, and stirring thoroughly to obtain solution B;
and step 3: adding deionized water into the standby liquid B in proportion, continuously stirring uniformly, and cooling to obtain standby liquid C;
and 4, step 4: mixing the herba Menthae extractive solution and the solution C at a certain proportion, and stirring to obtain the final product.
8. The method for preparing an oral cleaning solution according to claim 7, wherein: in the step 3, the warming temperature of the edible sodium chloride added into the standby liquid A is between 30 and 40 ℃.
CN202111034757.9A 2021-09-04 2021-09-04 Oral cavity cleaning liquid and preparation method and application thereof Pending CN115770205A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111034757.9A CN115770205A (en) 2021-09-04 2021-09-04 Oral cavity cleaning liquid and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111034757.9A CN115770205A (en) 2021-09-04 2021-09-04 Oral cavity cleaning liquid and preparation method and application thereof

Publications (1)

Publication Number Publication Date
CN115770205A true CN115770205A (en) 2023-03-10

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Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376374A (en) * 1993-05-24 1994-12-27 Zelaya; Luz M. Oral rinse composition
EP1236466A1 (en) * 2001-02-28 2002-09-04 Efrat Biopolymers Ltd. Absorbable solid compositions for topical treatment of oral mucosal disorders
CN1398611A (en) * 2001-11-15 2003-02-26 秦建华 Chinese herbal medicine composition for treating caries pain and its prepn
CN103520076A (en) * 2013-10-18 2014-01-22 柳州两面针股份有限公司 Application of compound traditional Chinese medicine extracts in preparation of health care products for oral care
CN103611128A (en) * 2013-11-29 2014-03-05 山东省立医院 Mouth wash for preventing dental ulcer
CN104248661A (en) * 2013-06-26 2014-12-31 青岛道合生物科技有限公司 Oral ulcer disinfection cleaning liquid
CN106562921A (en) * 2016-11-02 2017-04-19 李浩然 Liquid oral composition containing TCM active substances and tea tree essential oil
CN107648317A (en) * 2017-11-01 2018-02-02 甘肃陇神戎发药业股份有限公司 A kind of corydalis tuber analgesic oral spray and its preparation technology
CN107714777A (en) * 2017-11-24 2018-02-23 张龙兵 A kind of medicine for promoting canker sore recovery from illness
WO2020072850A1 (en) * 2018-10-04 2020-04-09 Stellalife, Inc. Compositions and methods for promoting and maintaining oral health
CN113209170A (en) * 2021-05-18 2021-08-06 深圳市真味生物科技有限公司 Electronic atomized liquid for relieving oral ulcer
CN113318057A (en) * 2021-06-08 2021-08-31 岳阳职业技术学院 Old people nursing toothpaste and preparation method and application thereof

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376374A (en) * 1993-05-24 1994-12-27 Zelaya; Luz M. Oral rinse composition
EP1236466A1 (en) * 2001-02-28 2002-09-04 Efrat Biopolymers Ltd. Absorbable solid compositions for topical treatment of oral mucosal disorders
CN1398611A (en) * 2001-11-15 2003-02-26 秦建华 Chinese herbal medicine composition for treating caries pain and its prepn
CN104248661A (en) * 2013-06-26 2014-12-31 青岛道合生物科技有限公司 Oral ulcer disinfection cleaning liquid
CN103520076A (en) * 2013-10-18 2014-01-22 柳州两面针股份有限公司 Application of compound traditional Chinese medicine extracts in preparation of health care products for oral care
CN103611128A (en) * 2013-11-29 2014-03-05 山东省立医院 Mouth wash for preventing dental ulcer
CN106562921A (en) * 2016-11-02 2017-04-19 李浩然 Liquid oral composition containing TCM active substances and tea tree essential oil
CN107648317A (en) * 2017-11-01 2018-02-02 甘肃陇神戎发药业股份有限公司 A kind of corydalis tuber analgesic oral spray and its preparation technology
CN107714777A (en) * 2017-11-24 2018-02-23 张龙兵 A kind of medicine for promoting canker sore recovery from illness
WO2020072850A1 (en) * 2018-10-04 2020-04-09 Stellalife, Inc. Compositions and methods for promoting and maintaining oral health
CN113209170A (en) * 2021-05-18 2021-08-06 深圳市真味生物科技有限公司 Electronic atomized liquid for relieving oral ulcer
CN113318057A (en) * 2021-06-08 2021-08-31 岳阳职业技术学院 Old people nursing toothpaste and preparation method and application thereof

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Title
李秀芝: "《护理学基础》", 中国医药科技出版社, pages: 192 *

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Application publication date: 20230310