CN115770205A - Oral cavity cleaning liquid and preparation method and application thereof - Google Patents
Oral cavity cleaning liquid and preparation method and application thereof Download PDFInfo
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- 238000004140 cleaning Methods 0.000 title claims abstract description 34
- 210000000214 mouth Anatomy 0.000 title claims abstract description 27
- 239000007788 liquid Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 49
- 239000011780 sodium chloride Substances 0.000 claims abstract description 24
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- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 16
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- 235000015266 Plantago major Nutrition 0.000 claims abstract description 15
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- 239000003765 sweetening agent Substances 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000008367 deionised water Substances 0.000 claims abstract description 13
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 13
- 235000006679 Mentha X verticillata Nutrition 0.000 claims abstract description 9
- 235000002899 Mentha suaveolens Nutrition 0.000 claims abstract description 9
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000000243 solution Substances 0.000 claims description 71
- 239000000284 extract Substances 0.000 claims description 29
- 238000003756 stirring Methods 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 8
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- 208000025157 Oral disease Diseases 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 4
- 208000030194 mouth disease Diseases 0.000 claims description 4
- 239000011550 stock solution Substances 0.000 claims description 4
- 238000010792 warming Methods 0.000 claims description 4
- 239000000811 xylitol Substances 0.000 claims description 4
- 235000010447 xylitol Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 4
- 229960002675 xylitol Drugs 0.000 claims description 4
- 229940051866 mouthwash Drugs 0.000 claims description 3
- NUFKRGBSZPCGQB-FLBSXDLDSA-N (3s)-3-amino-4-oxo-4-[[(2r)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid;pentahydrate Chemical compound O.O.O.O.O.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C NUFKRGBSZPCGQB-FLBSXDLDSA-N 0.000 claims description 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 2
- 239000004377 Alitame Substances 0.000 claims description 2
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 claims description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 2
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 2
- 229960004998 acesulfame potassium Drugs 0.000 claims description 2
- 239000000619 acesulfame-K Substances 0.000 claims description 2
- 235000019409 alitame Nutrition 0.000 claims description 2
- 108010009985 alitame Proteins 0.000 claims description 2
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 claims description 2
- 229940105902 mint extract Drugs 0.000 claims description 2
- 229960001462 sodium cyclamate Drugs 0.000 claims description 2
- 229940013618 stevioside Drugs 0.000 claims description 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- 241000234295 Musa Species 0.000 claims 4
- 240000008790 Musa x paradisiaca Species 0.000 abstract description 11
- 208000002193 Pain Diseases 0.000 description 8
- 206010061218 Inflammation Diseases 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000004821 distillation Methods 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 230000001680 brushing effect Effects 0.000 description 3
- 210000003800 pharynx Anatomy 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
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- 241000196324 Embryophyta Species 0.000 description 1
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000009019 Pericoronitis Diseases 0.000 description 1
- 208000001143 Periodontal Abscess Diseases 0.000 description 1
- 244000134552 Plantago ovata Species 0.000 description 1
- 235000003421 Plantago ovata Nutrition 0.000 description 1
- 239000009223 Psyllium Substances 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- 206010044016 Tooth abscess Diseases 0.000 description 1
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- 230000023555 blood coagulation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000001277 chronic periodontitis Diseases 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
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- 239000007789 gas Substances 0.000 description 1
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- 230000000762 glandular Effects 0.000 description 1
- 238000013168 hemostasis test Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 208000002741 leukoplakia Diseases 0.000 description 1
- 201000011486 lichen planus Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 208000004480 periapical periodontitis Diseases 0.000 description 1
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- 230000000144 pharmacologic effect Effects 0.000 description 1
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- 229940070687 psyllium Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000008354 sodium chloride injection Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000003670 sublingual gland Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an oral cleaning solution, a preparation method and an application thereof, belonging to the field of oral treatment, wherein the oral cleaning solution comprises the following raw materials in parts by weight: the oral cavity cleaning liquid comprises, by weight, 0.1-2 parts of edible sodium chloride, 0.1-5 parts of plantain herb extracting solution, 0.1-2.5 parts of rhizoma corydalis extracting solution, 0.1-7.5 parts of honeysuckle extracting solution, 0.1-5 parts of mint extracting solution, 0.1-3 parts of sweetening agent and 50-75 parts of deionized water.
Description
Technical Field
The invention relates to the field of oral treatment, in particular to an oral cleaning fluid and a preparation method and application thereof.
Background
The oral cavity is the initial part of the digestive system, the front wall of the oral cavity is an upper lip and a lower lip, the side wall of the oral cavity is a cheek, the upper wall is a palate, the lower wall of the oral cavity is an oral floor, the oral cavity is led to the outside through a cleft mouth surrounded by the lips forwards, and is communicated with the pharynx through a pharynx gorge backwards, the oral cavity can be divided into an oral cavity vestibule and an inherent oral cavity, the former is a gap between the upper lip and the lower lip and the cheek, an upper dental arch and a lower dental arch and gum, the latter is a space surrounded by the upper dental arch, the lower dental arch and the gum, the top of the oral cavity is the palate, and the bottom of the oral cavity is composed of mucous membranes, muscles and skin;
the most common oral diseases are diseases of the tissues of the tooth body, such as dental caries, tooth trauma or pulpitis, periapical periodontitis and the like, and also diseases of supporting tissues around the tooth, such as tooth loosening caused by gingival recession, chronic periodontitis or pericoronitis of wisdom tooth, periodontal abscess and the like, and are also rare, but once serious mucosal diseases occur, such as lichen planus, leukoplakia or other tumors and the like, the oral diseases are also possible to be glandular diseases, because the oral cavity has more glands, sublingual glands, sublabial glands or parotid, inflammation or tumors can occur.
Tooth brushing is an important method for keeping oral hygiene, and tooth brushing is a good hygiene habit every day, but when a wound appears in the oral cavity, tooth brushing and mouth rinsing are often accompanied by bleeding and pain, infection is easily caused at an oral window, and disinfection treatment needs to be carried out in time.
Disclosure of Invention
The invention aims to solve the technical problem that most oral cleaning solutions use components such as hydrogen peroxide solution, sodium bicarbonate solution, sodium chloride injection and the like, so that oral mucosa is damaged, and provides an oral cleaning solution and a preparation method and application thereof, so as to solve the problems.
In order to achieve the purpose, the invention provides the following technical scheme: an oral cleaning solution comprises the following raw materials in parts by weight: 0.1-2 parts of edible sodium chloride, 0.1-5 parts of plantain herb extract, 0.1-2.5 parts of rhizoma corydalis extract, 0.1-7.5 parts of honeysuckle extract, 0.1-5 parts of mint extract, 0.1-3 parts of sweetening agent and 50-75 parts of deionized water.
The edible sodium chloride is generally used as 0.9 percent normal saline, aiming at establishing a hypertonic environment at the local part of the oral cavity, being not beneficial to the growth of bacteria and playing a role in preventing the growth of the bacteria;
the plantain herb can be used for hemostasis, has the functions of clearing heat and promoting urination, has the functions of reducing phlegm, cooling blood and detoxifying, and is used for treating hematemesis, nosebleed and carbuncle sore pyogenic infections;
the rhizoma corydalis can be widely applied to symptoms such as pain of all parts of the whole body caused by blood stasis and qi stagnation, can activate blood and promote qi circulation, has good pain relieving effect, and can be widely applied to the pain of all parts of the whole body caused by blood stasis and qi stagnation;
the honeysuckle extract and some chemical components contained in the honeysuckle extract have various pharmacological effects, mainly comprise anti-inflammatory, antibacterial, antiviral, antioxidant and the like, and have anti-inflammatory and antibacterial effects;
the mint has the main effects of dispelling wind and heat, detoxifying and promoting eruption, clearing throat, soothing liver and regulating qi.
Further, the oral cavity cleaning liquid comprises the following raw materials in parts by weight: 2 parts of edible sodium chloride, 5 parts of plantain herb extracting solution, 2.5 parts of rhizoma corydalis extracting solution, 5.5 parts of honeysuckle extracting solution, 3 parts of mint extracting solution, 2 parts of sweetening agent and 75 parts of deionized water.
Further, the oral cavity cleaning liquid comprises the following raw materials in parts by weight: 1 part of edible sodium chloride, 2 parts of plantain herb extracting solution, 1 part of rhizoma corydalis extracting solution, 7.5 parts of honeysuckle extracting solution, 5 parts of mint extracting solution, 2 parts of sweetening agent and 70 parts of deionized water.
Further, the sweetener comprises any one or more of xylitol, sweetener, acesulfame potassium, stevioside, alitame or sodium cyclamate.
Further, the plantain herb extracting solution, the corydalis tuber extracting solution and the honeysuckle extracting solution are respectively extracted by adopting a steam distillation method.
The steam distillation method is the most common method for extracting the plant natural perfume, the technology in the aspects of flow, equipment, operation and the like is mature, the cost is low, the yield is high, the equipment and the operation are simple, and the method is divided into three forms: distillation in water, distillation in water and water-gas distillation, and any distillation method can be used.
Further, the oral cleaning solution is applied to treating oral diseases.
A preparation method of an oral cleaning solution comprises the following preparation steps:
step 1: mixing herba plantaginis extract, rhizoma corydalis extract, flos Lonicerae extract and sweetener at a certain proportion, stirring thoroughly to obtain stock solution A;
step 2: adding edible sodium chloride into the solution A at a certain proportion, heating for 5-10 min until the edible sodium chloride is completely dissolved, and stirring thoroughly to obtain solution B;
and step 3: adding deionized water into the standby liquid B in proportion, continuously stirring uniformly, and cooling to obtain standby liquid C;
and 4, step 4: mixing the herba Menthae extractive solution and the solution C at a certain proportion, and stirring to obtain the final product.
Further, the warming temperature of the edible sodium chloride added into the standby liquid A in the step 3 is between 30 and 40 ℃.
Compared with the prior art, the invention has the following beneficial effects: the invention relates to an oral cavity cleaning liquid and a preparation method and application thereof, wherein traditional Chinese medicine herbs are used as a base, edible sodium chloride is used for sterilization, plantain herb extracting solution is used for hemostasis, rhizoma corydalis extracting solution is used for relieving pain, honeysuckle flower extracting solution is used for diminishing inflammation, mint extracting solution is used for deodorization, the oral cavity cleaning liquid is non-toxic and harmless, sweet in taste, capable of sterilizing and diminishing inflammation, capable of stopping bleeding and relieving pain, and does not cause excessive stimulation to the environment in an oral cavity.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the embodiment is an oral cavity cleaning solution, which comprises the following raw materials in parts by weight: 2 parts of edible sodium chloride, 5 parts of plantain herb extracting solution, 2.5 parts of rhizoma corydalis extracting solution, 5.5 parts of honeysuckle extracting solution, 3 parts of mint extracting solution, 2 parts of xylitol and 75 parts of deionized water.
In this example, the plantain herb extract, the corydalis tuber extract and the honeysuckle flower extract were extracted by steam distillation, respectively.
A preparation method of an oral cleaning solution comprises the following preparation steps:
step 1: mixing herba plantaginis extract, rhizoma corydalis extract, flos Lonicerae extract and sweetener at a certain proportion, stirring thoroughly to obtain stock solution A;
step 2: adding edible sodium chloride into the standby liquid A according to a certain proportion, heating for 10 minutes until the edible sodium chloride is completely dissolved, and fully stirring to prepare a standby liquid B;
and step 3: adding deionized water into the solution B, stirring, and cooling to obtain solution C;
and 4, step 4: mixing the herba Menthae extract and the solution C at a certain proportion, and stirring to obtain the final product.
Further, the warming temperature of the edible sodium chloride added into the standby liquid A in the step 3 is between 40 ℃.
Example 2:
the embodiment is an oral cleaning solution, which comprises the following raw materials in parts by weight: 1 part of edible sodium chloride, 2 parts of plantain herb extracting solution, 1 part of rhizoma corydalis extracting solution, 7.5 parts of honeysuckle extracting solution, 5 parts of mint extracting solution, 2 parts of xylitol and 70 parts of deionized water.
In this embodiment, the plantain herb extract, the corydalis tuber extract and the honeysuckle flower extract are extracted by steam distillation respectively.
A preparation method of an oral cleaning solution comprises the following preparation steps:
step 1: mixing herba plantaginis extract, rhizoma corydalis extract, flos Lonicerae extract and sweetener at a certain proportion, stirring thoroughly to obtain stock solution A;
step 2: adding edible sodium chloride into the standby liquid A according to a certain proportion, heating for 10 minutes until the edible sodium chloride is completely dissolved, and fully stirring to prepare a standby liquid B;
and step 3: adding deionized water into the standby liquid B in proportion, continuously stirring uniformly, and cooling to obtain standby liquid C;
and 4, step 4: mixing the herba Menthae extractive solution and the solution C at a certain proportion, and stirring to obtain the final product.
Further, the warming temperature of the edible sodium chloride added into the standby liquid A in the step 3 is between 38 ℃.
Example 3:
this example provides an anti-mouth rinse, which differs from example 1 in that no edible sodium chloride is added.
Example 4:
this example provides an anti-mouth rinse, which differs from example 1 in that no psyllium extract is added.
Example 5:
this example provides an anti-oral rinse, which differs from example 1 in that no rhizoma corydalis extract is added.
The oral rinse solutions prepared in examples 1-5 were subjected to the following tests:
2 cases of oral inflammation patients are selected, the oral cleaning solutions prepared in the embodiments 1, 2 and 5 are used respectively, according to the description of the patients, the pain of the patients using the oral cleaning solution prepared in the embodiment 1 disappears obviously, the pain of the patients using the oral cleaning solution prepared in the embodiment 2 is relieved, and the patients using the oral cleaning solution prepared in the embodiment 5 has no change;
bacteriostatic tests were carried out on the oral cleaning solutions prepared in examples 1 to 5, respectively, and the results showed that the oral cleaning solution prepared in example 3 had poor bacteriostatic activity;
the oral cavity rinses prepared in examples 1 to 5 were subjected to hemostasis tests, respectively, and as a result, the oral cavity rinses prepared in example 3 had a low blood coagulation rate.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. An oral cleaning solution, characterized in that: the oral cavity cleaning liquid comprises the following raw materials in parts by weight: 0.1-2 parts of edible sodium chloride, 0.1-5 parts of plantain herb extract, 0.1-2.5 parts of rhizoma corydalis extract, 0.1-7.5 parts of honeysuckle extract, 0.1-5 parts of mint extract, 0.1-3 parts of sweetening agent and 50-75 parts of deionized water.
2. The oral cleaning solution according to claim 1, which comprises the following raw materials in parts by weight: 2 parts of edible sodium chloride, 5 parts of plantain herb extracting solution, 2.5 parts of rhizoma corydalis extracting solution, 5.5 parts of honeysuckle extracting solution, 3 parts of mint extracting solution, 2 parts of sweetening agent and 75 parts of deionized water.
3. An oral cleaning solution according to claim 1, wherein: the oral cleaning liquid comprises the following raw materials in parts by weight: 1 part of edible sodium chloride, 2 parts of plantain herb extracting solution, 1 part of rhizoma corydalis extracting solution, 7.5 parts of honeysuckle extracting solution, 5 parts of mint extracting solution, 2 parts of sweetening agent and 70 parts of deionized water.
4. An oral cleaning solution according to claim 1, wherein: the sweetener comprises any one or more of xylitol, sweetener, acesulfame potassium, stevioside, alitame or sodium cyclamate.
5. An oral cleaning solution according to claim 1, wherein: the plantain herb extracting solution, the corydalis tuber extracting solution and the honeysuckle extracting solution are respectively extracted by adopting a steam distillation method.
6. Use of an oral rinse according to any of claims 1 to 5 for the treatment of oral disorders.
7. The preparation method of the oral cleaning liquid is characterized by comprising the following preparation steps:
step 1: mixing herba plantaginis extract, rhizoma corydalis extract, flos Lonicerae extract and sweetener at a certain proportion, stirring thoroughly to obtain stock solution A;
and 2, step: adding edible sodium chloride into the solution A at a certain proportion, heating for 5-10 min until the edible sodium chloride is completely dissolved, and stirring thoroughly to obtain solution B;
and step 3: adding deionized water into the standby liquid B in proportion, continuously stirring uniformly, and cooling to obtain standby liquid C;
and 4, step 4: mixing the herba Menthae extractive solution and the solution C at a certain proportion, and stirring to obtain the final product.
8. The method for preparing an oral cleaning solution according to claim 7, wherein: in the step 3, the warming temperature of the edible sodium chloride added into the standby liquid A is between 30 and 40 ℃.
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