CN103463253B - Fungus medicament for preventing postoperative cancer recurrence and production method thereof - Google Patents
Fungus medicament for preventing postoperative cancer recurrence and production method thereof Download PDFInfo
- Publication number
- CN103463253B CN103463253B CN201310444293.8A CN201310444293A CN103463253B CN 103463253 B CN103463253 B CN 103463253B CN 201310444293 A CN201310444293 A CN 201310444293A CN 103463253 B CN103463253 B CN 103463253B
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- fungus
- medicament
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a fungus medicament for preventing postoperative cancer recurrence and a production method thereof. The fungus medicament for preventing postoperative cancer recurrence is prepared by the following raw materials in parts by weight: 23 parts of mythic fungus wall-broken spore powder, 13 parts of mythic fungus extract, 2 parts of agaricus brasiliensis extract, 3 parts of polyporus extract, 1 part of cordyceps sinensis extract, 12 parts of hedyotis diffusa extract and 15 parts of barbat skullcap extract; also the fungus medicament additionally comprises 1 part of ginseng extract and 5 parts of dog meat extract. The production method comprises: uniformly mixing the above extracts with mythic fungus wall-broken spore powder, drying, pulverizing and processing into capsules. The key point of the fungus medicament of the invention is that: according to the theories of traditional Chinese medicine, traditional Chinese medicine syndrome differentiation treatment and 'monarch and minister, assistant and guide', the above six traditional Chinese medicines are subjected to scientific compatibility, so that an effective medicine combination is established. Mice experiments prove that the fungus medicament has substantial cancer inhibiting effect and almost does not have any toxic and side effects on human body. The advantage that the fungus medicament belongs to a nontoxic immunization activator is precisely not owned by many anticancer cancer-treating chemotherapeutic medicaments and other immunization activators.
Description
Technical field
The present invention relates to the medicine of Therapeutic cancer, i.e. the fungi-medicine of the postoperative anti-recurrence of a kind of cancer and production method thereof.
Background technology
Cancer is in two years postoperative, and its recurrence and transfer probability are higher.So client need is made regular check on, life, diet also will do suitable adjustment.At present, also do not have reasonable way can the postoperative recurrence of prophylaxis of cancer or transfer, the adjuvant chemotherapy of postoperative specification and radiotherapy can reduce the relapse and metastasis of cancer or extend the time of relapse and metastasis, but still have the possibility of relapse and metastasis, as a rule, postoperative cancer patient needs just check once for every 3 ~ 4 months, and drop curing cancer drug, be in hospital about 10 days, such frequency will adhere to 2 years at least; After 2 years, half a year can be made into once, and then adhere to 3 years.Need so altogether treatment 5 years.On the other hand, cancer is postoperative, radiotherapy in addition, chemotherapy, health weakness very.As a whole, cancer is postoperative to be prevented from recurring and getting well is a more difficult thing, Chinese medicine can be utilized to prevent cancer postoperative recurrence and to accelerate to get well, it is a new problem, at present, somebody attempts by Ganoderma, Herba Hedyotidis Diffusae or the Herba Scutellariae Barbatae auxiliary treatment as cancer, but finds that said medicine not only works to cancerous cell, and also has certain infringement to healthy cell.
Summary of the invention
In order to solve cancer postoperative recurrence and restorative problem, the present invention proposes fungi-medicine and the production method thereof of the postoperative anti-recurrence of a kind of cancer.
The fungi-medicine of the postoperative anti-recurrence of this cancer, is characterized in that, be made up: Sporoderm-broken Ganoderma Lucidum Spore powder of the raw material of following part by weight, 23 parts; Ganoderma extract, 13 parts; Agaricus blazei Murrill extract, 2 parts; Polyporus extract, 3 parts; Cordyceps extract, 1 part; Herba Hedyotidis Diffusae extract, 12 parts; Herba Scutellariae Barbatae extract, 15 parts.
The production method of the fungi-medicine of the postoperative anti-recurrence of this cancer, it is characterized in that, point two steps: one, get Ganoderma, Agaricus blazei Murrill, Polyporus, Cordyceps, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae be ground into coarse powder respectively, use 70% ethanol as solvent, flood 48 hours, filter, collect leakage, be concentrated into relative density be 1.12 clear paste be extract; Buy commercially available Sporoderm-broken Ganoderma Lucidum Spore powder;
Two, mixed homogeneously with Sporoderm-broken Ganoderma Lucidum Spore powder by above-mentioned six kinds of extracts, dry, powder process, is processed into capsule.
For the patient that postoperative body constitution is very weak, Radix Ginseng extract 1 part is increased in the raw material of part by weight, Carnis Canitis extract 5 parts, the manufacture method of Radix Ginseng extract is identical with the manufacture method of above-mentioned six kinds of extracts, the manufacture method of Carnis Canitis extract produces Carnis Canitis degrease clear paste with biological enzymolysis technology, the process conditions obtaining the best enzymolysis of Carnis Canitis are: with the papain of Carnis Canitis weight 0.5% in Carnis Canitis, with the water of Carnis Canitis weight 6 times, react 6 hours under constant temperature 60 DEG C of conditions, filter, filtrate is placed, remove the oils and fats solidified, filtrate is concentrated into the clear paste of relative density about 1.12.The manufacture method of the medicine taken for the patient that postoperative body constitution is very weak is mixed homogeneously with Sporoderm-broken Ganoderma Lucidum Spore powder by above-mentioned eight kinds of extracts, and dry, powder process, is processed into capsule.
Ganoderma, for monarch drug of the present invention, containing 150 multiple compounds such as polysaccharide, peptidoglycan class, triterpenes, alkaloid, amino acids, ucleosides, fats, alkanoic acid, nicotinic acid, spore powder reducing sugar, spore powder polypeptide, spore ethers in Ganoderma composition, T cell group in energy human activin, D cell, macrophage, strengthen human body natural and kill and wound the ability of cancerous cell, effective Tumor suppression, reduce lump, leukocyte increasing; Immune system strengthens, and prevents recurrence and the transfer of tumor.
Herba Scutellariae Barbatae is ministerial drug of the present invention, effective ingredient alkaloid, flavonoid glycoside, phenols etc., to the sarcoma 180 in zoopery tumor, ehrlich carcinoma, cervical cancer 14, cerebroma 22, etc. all have certain inhibitory action; And have the effect of anti-hepatocarcinoma, gastric cancer, rectal cancer.
Herba Hedyotidis Diffusae, for ministerial drug of the present invention, containing Herba Hedyotidis Diffusae element, coumarin, ursolic acid, oleanolic acid, stigmasterol, B-sitosterol and fatty acid, alkaloid, flavonoid etc., the tumor cell of these active ingredients to acute lymphoblastic type, granulocyte type, monocyte type and chronic granulocyte type has stronger inhibitory action; Significant inhibitory action is had to animal white mice hepatic ascites cell, white mice sarcoma 180.
Cordyceps is adjuvant drug of the present invention, and containing cordycepin, multiple histone, fungal antibiotic, fungus polysaccharide, selenium element, effect of Cordyceps is kidney-reinforcing Yang-strengthening, and tonifying the lung is relievingd asthma, hemostasis and phlegm.There is effect of invigorating the lung and the kidney, hemostasis and phlegm.For chronic cough dyspnea due to deficiency, chronic cough is spat blood, impotence and seminal emission, soreness of waist and knee joint.
Polyporus, medicine is made for of the present invention, containing active ingredients such as ergosterol, α hydroxyl-24 carbonic acid, biotin, water solublity polysaccharide compound Polyporus polysaccharide I and crude protein, experiment shows, polyporusum bellatus can improve T cell immunologic function, there is regulating action to humoral immunization, and the weakling of immunologic hypofunction can be made hale and hearty.Agaricus blazei Murrill, makes medicine for of the present invention, containing active ingredients such as abundant mannan, active nucleic acid, reactive sterol class and external source coagulin, aminoacid; Wherein the necessary aminoacid of human body accounts for 50.18% of its total content, is particularly rich in polysaccharide body.Every 1 gram of Agaricus blazei Murrill is about just containing 60-70 milligram polysaccharide body, and the healthy scientific research institution of Japan internationality claims Agaricus blazei Murrill to be save patient with advanced cancer " last food ".
Radix Ginseng has " tonifying five ZANG-organs, peace spirit, determine soul, spasmolytic is throbbed with fear, except pathogen, the happy Fructus Alpiniae Oxyphyllae of improving eyesight " effect.Carnis Canitis not only protein content is high, and protein quality is splendid, especially large with globulin, has obvious effect to enhancing body premunition and cell viability and organ dysfunction.
According to the theory of the traditional Chinese medical science, Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, monarch, carrying out scientific compatibility to above-mentioned eight kinds of Chinese medicines, propose effective drug regimen, is key point of the present invention.Have as the Ganoderma of monarch drug of the present invention, ministerial drug, Herba Hedyotidis Diffusae and Herba Scutellariae Barbatae that anticancer brings back to life, the effect of growth, but there is certain injury for healthy cell, as adjuvant drug of the present invention, make the Agaricus blazei Murrill of medicine, Polyporus and Cordyceps be the balance regulating human body, monarch drug can be alleviated, the poison of ministerial drug pays effect.Tested by white mice, suppress cancer Be very effective; To human body almost without any toxic and side effects.The advantage of this avirulent immune activation agent, the chemotherapeutics of many cancer preventing and treatings and other immunopotentiating agent do not have exactly.
Detailed description of the invention
Below by embodiment, the present invention is described in detail
The fungi-medicine of the postoperative anti-recurrence of this cancer, is made up of the raw material of following weight: Sporoderm-broken Ganoderma Lucidum Spore powder 2300g, Ganoderma extract 1300g, Agaricus blazei Murrill extract 200g, polyporus extract 300g, Cordyceps extract 100g, Herba Hedyotidis Diffusae extract 1200g, Herba Scutellariae Barbatae extract 1500g.
The production method of the fungi-medicine of the postoperative anti-recurrence of this cancer, point two steps: one, get Ganoderma, Agaricus blazei Murrill, Polyporus, Cordyceps, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae be ground into coarse powder respectively, use 70% ethanol as solvent, flood 48 hours, filter, collect leakage, be concentrated into relative density be 1.12 clear paste be extract; Buy the Sporoderm-broken Ganoderma Lucidum Spore powder that the Chinese Academy of Agricultural Sciences sells;
Two, mixed homogeneously with Sporoderm-broken Ganoderma Lucidum Spore powder by above-mentioned six kinds of extracts, dry, powder process, is processed into capsule, and every capsules is containing active drug 0.1g.
For the patient that postoperative body constitution is very weak, increase Radix Ginseng extract 100g, Carnis Canitis extract 500g in the feed, the manufacture method of Radix Ginseng extract is identical with the method for above-mentioned six kinds of extracts, the manufacture method of Carnis Canitis extract produces Carnis Canitis degrease clear paste with biological enzymolysis technology, the process conditions obtaining the best enzymolysis of Carnis Canitis are: with the papain of Carnis Canitis weight 0.5% in Carnis Canitis, with the water of Carnis Canitis weight 6 times, react 6 hours under constant temperature 60 DEG C of conditions, filter, filtrate is placed, remove the oils and fats solidified, filtrate is concentrated into the clear paste of relative density about 1.12.The patient that postoperative body constitution is very weak the manufacture method of thing of taking medicine be that above-mentioned eight kinds of extracts are mixed homogeneously with Sporoderm-broken Ganoderma Lucidum Spore powder, dry, powder process, is processed into capsule, and every capsules is containing active drug 0.1g.
The medicine that the present invention's Sporoderm-broken Ganoderma Lucidum Spore powder and Ganoderma, Agaricus blazei Murrill, Polyporus, Cordyceps, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, these six kinds of extracts make has carried out mouse experiment S
180growing sarcoma Inhibition test:
Experiment material: Kunming mouse, body weight 20 adds and subtracts 2 grams, ad lib, drinking-water before experiment, natural light irradiation;
Experimental technique: adopt the mice milky ascites gone down to posterity 5-7 days, be diluted to tumor cell suspension with physiological saline solution, cell number is 10
7/ ml, every experimental mouse at axillary fossa subcutaneous vaccination tumor cell suspension 0.2ml, containing oncocyte 2x10
6individual, make there is S in experiment mice body
180sarcoma, inoculation random packet next day, often organizes 5, be divided into 4 groups, first group, will not treat, second group, take cyclophosphamide 10g/d.kg to treat, the 3rd group, take cyclophosphamide 10g/d.kg and treat, 100mg/g medicine of the present invention is added in the food of mice, 4th group, take cyclophosphamide 10g/d.kg and treat, in the food of mice, add 200mg/g medicine of the present invention; Continuous experiment 10 days, conventional raises, and drinking-water, food are not limit, drug withdrawal next day, and mice is all slaughtered, and strips subcutaneous solid tumors block, weighs, by following formulae discovery tumor control rate:
Suppression ratio=(first group of average tumor heavy-other organize average tumor weight)/first group of average tumor weight.
The suppression ratio of second group is: 32%;
The suppression ratio of the 3rd group is: 41%;
The suppression ratio of the 4th group is: 53%;
White mice experiment conclusion: drug on tumor of the present invention has significant inhibitory action.
Cancer patient's instructions of taking: every day takes night and morning, each 3-5, middle and terminal cancer patient treatment, morning, noon and afternoon every day each edible once, each 5, Radix Ginseng, Carnis Canitis compound capsule are taken for weakling, can therapeutic effect be increased, obviously reduce operation, chemotherapy, radiotherapy brings severe reaction, go home between recuperation period, the long-term edible medicine of the present invention of suggestion, has the positive effect preventing cancer cell metastasis from recurring, extend patient's life-span, improve rehabilitation survival rate.
Inventor began one's study from nineteen ninety-five, constantly formula has been improved since 18 years, did the compositional refinements test of thousands of times, there is several cancer patient, as esophageal carcinoma, gastric cancer, hepatocarcinoma, pulmonary carcinoma, breast carcinoma, malignant lymphoma, rhinocarcinoma, thyroid carcinoma, the edible for patients such as leukemia cross medicine of the present invention, cancer patient wherein on the books 26, wherein man 16, female 10, less than 30 years old 1, 3 of 31-40 year, 5 of 41-50 year, 7 of 51-60 year, 9 of 61-70 year, more than 70 years old 1, they suffer from various cancer respectively, and carry out receiving and distributing art or radiotherapy, chemotherapy, after postoperative edible medicine of the present invention, total effective rate reaches 80.4%, obvious effective rate reaches 67%, relapse rate only 18.67% after 1 year, compare 53.5% of only single recurrence after operation rate.Reduce nearly 3 times, relapse rate is only 41.2% in two years, reduces nearly one times.Now take passages four patient's cases as follows:
Song, man, rectal cancer is diagnosed as by logistics hospital general, Beijing during 65 years old calendar year 2001, carry out Post operation, adopt chemotherapy toxic side effect very serious, once " Chinese ganoderma extract " sunrecome was taken, due to too expensive, unstable condition, change edible medicine of the present invention 5 years into, appetite enhancing, antisecosis, walk energetically, on the face also gradually mantle with blushes color, spirit is very good, sleep is also fine, because immunity strengthens, never recurrence afterwards, he can also often participate in some social community works and out on tours in more than 80 year old now.
Liu, man, 69 years old, in August, 2004 is diagnosed as hepatocarcinoma through Hunan Xiang Ya hospital, every month chemotherapy once, toxicity is very serious, hyperemesis, sleep not all right, stool is smooth, be off one's feed, repeatedly canceration Index for examination is abnormal, after take medicine of the present invention after, sleep obviously improves, appetite obviously strengthens, it is also very unimpeded to defecate, spirit is also very good with health, make him complete six chemotherapy smoothly, more to one's surprise is obviously decline through the indices repeatedly checked about canceration, has now recovered normal.
Zhang, man, 75 years old, be diagnosed as gastric cancer in People's Hospital, Hunan Prov. on July 2nd, 2003, carry out stomach Partial Resection Post operation in Hunan Provincial Tumour Hospital and shift concurrent esophageal carcinoma, during chemotherapy, leukocyte only has 3000/ cubic millimeter. spiritual extreme difference, the toxicity that has a delicate constitution is serious, rear long-term edible medicine of the present invention, present spirit be clearly better appetite, sleep might as well, antisecosis is normal, often participates in some friends rally, tourism of going out.
Arm spread, female, June nineteen ninety-five, be diagnosed as malignant glioma in Hunan Xiang Ya hospital, lump maximum gauge 7.0 cm when 42 years old, pain unbearably, blurred vision, walking is inconvenient, will have an operation at that time need spend 7-8 ten thousand yuan in Xiang Ya hospital, because family is in rural area, economy is very difficult, can not move operation of opening cranium, take conservative treatment, take medicine of the present invention and reach 6 years, existing diameter of tumor narrows down to only has 1cM, health is good, and can be engaged in the work that some are slight, vision is clearly better.
Claims (1)
1. a production method for the fungi-medicine of the postoperative anti-recurrence of cancer, is characterized in that, prepare the raw material of following part by weight: Sporoderm-broken Ganoderma Lucidum Spore powder, 23 parts; Ganoderma extract, 13 parts; Agaricus blazei Murrill extract, 2 parts; Polyporus extract, 3 parts; Cordyceps extract, 1 part; Herba Hedyotidis Diffusae extract, 12 parts; Herba Scutellariae Barbatae extract, 15 parts; In three steps:
One, get Ganoderma, Agaricus blazei Murrill, Polyporus, Cordyceps, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae be ground into coarse powder respectively, use 70% ethanol as solvent, flood 48 hours, filter, collect leakage, be concentrated into relative density be 1.12 clear paste be extract; Buy commercially available Sporoderm-broken Ganoderma Lucidum Spore powder;
Two, in the raw material of part by weight, increase Radix Ginseng extract 1 part, Carnis Canitis extract 5 parts, the manufacture method of Radix Ginseng extract is identical with the manufacture method of Ganoderma extract, the manufacture method of Carnis Canitis extract produces Carnis Canitis degrease clear paste with biological enzymolysis technology, the process conditions obtaining the best enzymolysis of Carnis Canitis are: with the papain of Carnis Canitis weight 0.5% in Carnis Canitis, with the water of Carnis Canitis weight 6 times, react 6 hours under constant temperature 60 DEG C of conditions, filter, filtrate is placed, remove the oils and fats solidified, filtrate is concentrated into the clear paste of relative density about 1.12;
Three, mixed homogeneously with Sporoderm-broken Ganoderma Lucidum Spore powder by above-mentioned eight kinds of extracts, dry, powder process, is processed into capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310444293.8A CN103463253B (en) | 2013-09-27 | 2013-09-27 | Fungus medicament for preventing postoperative cancer recurrence and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310444293.8A CN103463253B (en) | 2013-09-27 | 2013-09-27 | Fungus medicament for preventing postoperative cancer recurrence and production method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103463253A CN103463253A (en) | 2013-12-25 |
| CN103463253B true CN103463253B (en) | 2015-03-18 |
Family
ID=49788445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310444293.8A Expired - Fee Related CN103463253B (en) | 2013-09-27 | 2013-09-27 | Fungus medicament for preventing postoperative cancer recurrence and production method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103463253B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138527B (en) * | 2014-08-13 | 2015-10-21 | 胡广 | A biological fermentation composition with anticancer effect and its application |
| CN113616737A (en) * | 2021-07-29 | 2021-11-09 | 山东臻稀生物科技有限公司 | Anti-tumor rare earth multi-bacterium sugar traditional Chinese medicine formula with low toxicity and no side effect |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008516A (en) * | 2010-12-16 | 2011-04-13 | 刘振钦 | Ultrafine powder traditional Chinese medicine for treating tumors |
| CN103083620A (en) * | 2013-01-30 | 2013-05-08 | 张波 | Traditional Chinese medicine composition for preventing and treating postoperative recurrence of cancer |
-
2013
- 2013-09-27 CN CN201310444293.8A patent/CN103463253B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008516A (en) * | 2010-12-16 | 2011-04-13 | 刘振钦 | Ultrafine powder traditional Chinese medicine for treating tumors |
| CN103083620A (en) * | 2013-01-30 | 2013-05-08 | 张波 | Traditional Chinese medicine composition for preventing and treating postoperative recurrence of cancer |
Non-Patent Citations (1)
| Title |
|---|
| 五黄寿命散防治癌症术后复发临床研究;方在望等;《山东中医杂志》;19981231;第17卷(第12期);540-542 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103463253A (en) | 2013-12-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102258563A (en) | Anti-cancer medicinal composition and Chinese medicinal composition | |
| CN102697035A (en) | Cordyceps anti-aging pellet | |
| WO2013071727A1 (en) | Anti-tumor traditional chinese medical composition | |
| CN103251873A (en) | Traditional Chinese veterinary medicine capable of helping to digest and remove retention | |
| CN101380346B (en) | Traditional Chinese composition for treating tumor and production method thereof | |
| CN102861193B (en) | Traditional Chinese medicine composition for treating gastric cancer | |
| CN103463253B (en) | Fungus medicament for preventing postoperative cancer recurrence and production method thereof | |
| TWI646964B (en) | Pharmaceutical composition, preparation method and use thereof for reducing side effects of cancer treatment drugs | |
| CN102579803A (en) | Medicine for treating post-chemotherapy leucopenia and preparation method thereof | |
| CN104940241B (en) | A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women | |
| CN101653466B (en) | Composition for treating cancers | |
| CN101391036B (en) | Medicine composition for treating lung cancer | |
| CN106310023A (en) | Drug for treating small cell lung cancer, and preparation method and application thereof | |
| CN102379905B (en) | Ganoderma lucidum spore oil-containing Chinese medicinal composition with efficient cancer resistance | |
| CN102078600B (en) | Anti-cancer compound ganoderma composition, application thereof and pharmaceutical composition containing same | |
| TWI601535B (en) | Use of compositions of water/alcohol extracts of antrodia cinnamomea cut-log cultivated fruiting body and solid-state cultivated mycelium as auxiliaries for anti-cancer agents | |
| CN106309758B (en) | Pharmaceutical composition for resisting gastrointestinal cancer | |
| CN1169315A (en) | Immunity-regulating health-care tea | |
| CN102423384B (en) | Traditional Chinese drug preparation for treating lung cancer, and preparation method thereof | |
| CN102526283A (en) | Health-care medicine formula with functions of enhancing immunity, alleviating physical fatigue and resisting tumor | |
| CN1911329A (en) | Traditional Chinese medicine composition for preventing and/or adjuvant therapy of malignant tumor | |
| CN102512460B (en) | Combination of genistein, ganoderma lucidum spore powder and cordyceps mycelium | |
| CN103830262A (en) | Auxiliary drug used for treating cancer, and applications thereof | |
| CN108578501A (en) | Ginseng composition with anticancer function | |
| CN102631506B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150318 Termination date: 20210927 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |