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CN103462696B - An integrated online real-time processor integrating intravascular optical coherence tomography (OCT) images and digital subtraction (DSA) images - Google Patents

An integrated online real-time processor integrating intravascular optical coherence tomography (OCT) images and digital subtraction (DSA) images Download PDF

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CN103462696B
CN103462696B CN201310424563.9A CN201310424563A CN103462696B CN 103462696 B CN103462696 B CN 103462696B CN 201310424563 A CN201310424563 A CN 201310424563A CN 103462696 B CN103462696 B CN 103462696B
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CN103462696A (en
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王建安
朱国忠
孙勇
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Zhejiang University ZJU
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Abstract

The invention provides the online processing instrument in real time of integration of a kind of integrated Ink vessel transfusing coherence of light tomoscan (OCT) image and Digital Subtraction (DSA) image, comprise data acquisition module, the blood vessel segmentation of DSA image rebuilds module, the interlocking module of the vessel measurement module of OCT image, blood vessel three-dimensional imaging module, DSA image and OCT image, image report module and transport module.The present invention is in conjunction with DSA image and OCT image, multi-faceted blood vessel to be processed, the contrast of the vessel measurements on the cross section obtained by the vessel measurement module of the blood vessel segmentation of DSA image being rebuild to vessel measurements that module obtains and OCT image, facilitate the vessel segment position that patient judges whether the capable interventional therapy of lesion vessels and interventional therapy, and then determine therapeutic scheme, and patient is helped accurately to select support size and locating support.

Description

一种集成血管内光相干断层扫描(OCT)影像和数字减影(DSA)影像的一体化在线实时处理仪An integrated online real-time processor integrating intravascular optical coherence tomography (OCT) images and digital subtraction (DSA) images

技术领域 technical field

本发明属于医疗设备领域,具体是指一种集成血管内光相干断层扫描(OCT)影像和数字减影(DSA)影像的一体化在线实时处理仪。  The invention belongs to the field of medical equipment, and specifically refers to an integrated online real-time processor integrating intravascular optical coherence tomography (OCT) images and digital subtraction (DSA) images. the

背景技术 Background technique

冠状动脉造影是诊断冠心病的一种有效方法。将导管经大腿股动脉、桡动脉或其它周围动脉插入,送至升主动脉,然后探寻左或右冠状动脉口插入,注入造影剂,使冠状动脉显影,能较明确地揭示冠状动脉的解剖畸形及其阻塞性病变的位置、程度与范围。冠状动脉造影是目前能直接观察冠状动脉形态的有效方法,医学界号称其为“金标准”。对于造影中狭窄较重的部位,需要进行介入治疗。 Coronary angiography is an effective method for the diagnosis of coronary heart disease. Insert the catheter through the femoral artery, radial artery or other peripheral arteries, send it to the ascending aorta, then explore the left or right coronary artery orifice, inject contrast agent, and visualize the coronary arteries, which can clearly reveal the anatomical abnormalities of the coronary arteries The location, degree and scope of its obstructive lesions. Coronary angiography is currently an effective method for directly observing the shape of coronary arteries, and the medical profession calls it the "gold standard". Interventional treatment is required for areas with severe stenosis on angiography.

在临床实际应用当中,冠状动脉造影也表现出诸多不足之处。如,它只能显示管腔的情况,不能显示病变所在的管壁和粥样斑块,不能提供粥样斑块形态和性质的详细情况,有可能使术者低估冠脉狭窄的程度。这就使得依据冠脉造影评价冠脉粥样硬化和介入治疗疗效的准确度降低。尤其是冠脉血管重构这一概念的提出,使得人们不得不重新评价冠脉造影在冠心病诊疗中的可靠性。在冠脉粥样硬化的早期,随着粥样斑块面积的增大,冠脉呈代偿性扩张,管腔面积可无狭窄,这一过程即血管重构,此时冠脉造影往往无异常表现。 In clinical practice, coronary angiography also shows many deficiencies. For example, it can only show the condition of the lumen, but cannot show the vessel wall and atheromatous plaque where the lesion is located, and cannot provide detailed information on the shape and nature of the atheromatous plaque, which may cause the operator to underestimate the degree of coronary stenosis. This reduces the accuracy of evaluating coronary atherosclerosis and interventional therapy based on coronary angiography. In particular, the introduction of the concept of coronary vascular remodeling has forced people to re-evaluate the reliability of coronary angiography in the diagnosis and treatment of coronary heart disease. In the early stage of coronary atherosclerosis, with the increase of atherosclerotic plaque area, the coronary artery is compensatory expansion, and the lumen area may not be narrowed. This process is vascular remodeling. At this time, coronary angiography often fails Abnormal behavior.

光学相干断层扫描(OCT),使用低相干光对生物组织进行横断面扫描,通过记录散射剖面与光束中每个横向位置的深度的对比曲线生成组织的截面图像,其使用了最新的高分辨率扫描技术,除具有无创伤、可重复性好的优点外,它能够测量分辨率 ≤ 10μm 的组织和距离,可对血管的斑块性质、支架钢梁等能进行精确分析。由于光相干性断层探头直接置于血管腔内探测,因此,血管内光相干性断层不仅可准确测量管腔及粥样斑块或纤维斑块的大小,更重要的是它可提供粥样斑块的大体组织信息,在显示因介入治疗所致的复杂的病变形态时明显优于造影。 Optical coherence tomography (OCT), which uses low-coherence light to scan cross-sections of biological tissues, generates cross-sectional images of tissues by recording the comparison curve of the scattering profile and the depth of each lateral position in the beam, which uses the latest high-resolution Scanning technology, in addition to the advantages of non-invasiveness and good repeatability, it can measure tissues and distances with a resolution of ≤ 10 μm, and can accurately analyze the plaque properties of blood vessels and stent steel beams. Since the optical coherence tomography probe is directly placed in the blood vessel cavity for detection, intravascular optical coherence tomography can not only accurately measure the size of the lumen and atheromatous plaque or fibrous plaque, but more importantly, it can provide The general tissue information of the block is obviously better than contrast in displaying the complex lesion morphology caused by interventional therapy.

对于一些血栓病变、支架内再狭窄等需要精确分析的病变,往往需要OCT的指导。然而,由于肉眼观察存在的局限性、医生和技师沟通的一些盲点等,很难精确地精确地将OCT影像与DSA影像结合在一起,对进一步保障经皮冠状动脉介入手术(PCI)质量提出了更高的难度。因此,一种能结合DSA影像和OCT影像,实现血管点对点测量的影像处理设备,将有力推动心血管介入手术的发展,保障手术的质量。而此类技术在国内尚属空白,因此具有很大的发展空间和研究价值。 For some lesions that require accurate analysis, such as thrombotic lesions and in-stent restenosis, OCT guidance is often required. However, due to the limitations of naked eye observation, some blind spots in communication between doctors and technicians, etc., it is difficult to accurately combine OCT images with DSA images. higher difficulty. Therefore, an image processing device that can combine DSA images and OCT images to realize point-to-point measurement of blood vessels will effectively promote the development of cardiovascular interventional surgery and ensure the quality of surgery. However, this kind of technology is still blank in China, so it has great development space and research value.

发明内容 Contents of the invention

针对背景技术所提出的问题,本发明的目的是提供一种集成血管内光相干断层扫描(OCT)影像和数字减影(DSA)影像的一体化在线实时处理仪。为此,本发明采用以下技术方案: In view of the problems raised by the background technology, the purpose of the present invention is to provide an integrated online real-time processor that integrates intravascular optical coherence tomography (OCT) images and digital subtraction (DSA) images. For this reason, the present invention adopts following technical scheme:

本发明包括七个模块:数据采集模块、DSA影像的血管分割重建模块、OCT影像的血管测量模块、血管三维成像模块、DSA影像和OCT影像的联动模块、影像报告模块以及传输模块。其中:(1)数据采集模块,包括在计算机内部嵌入含两路DVI接口的高清采集卡,用于在术中实时采集OCT影像和DSA影像,并存于计算机本地硬盘;(2)DSA影像的血管分割重建模块,用于对采集的DSA影像重建血管走形,对重建后的血管中被选择的感兴趣的血管段,勾勒血管中心线,在勾勒的血管中心线上标注感兴趣血管段的起始点和终末点;(3)OCT影像的血管测量模块,通过OCT导管的自身尺寸做参照,对OCT影像上被选择的感兴趣的图像进行全自动或人机互动式血管管腔的测量;所述全自动测量是指计算机根据血管横截面上的自身管腔和残余管腔的边界的灰度值的不同,自动获取自身管腔和残余管腔的边界,并获得测量结果;所述的人机互动式测量是指在计算机对感兴趣的图像进行所述的全自动测量的基础上,再提供操作者修改界面,接收操作者的指令,修改血管横截面上自身管腔和残余管腔的边界,OCT影像的血管测量模块根据新勾勒的血管管腔边界再进行所述测量。所述测量包括:血管横截面上的自身管腔与残余管腔的管腔面积、直径和斑块负荷,以及纵截面上血管的长度;所述的自身管腔是指原始的血管管腔,包括残余的血管管腔和斑块部分;所述的残余管腔是指目前现有的能供血流通过的血管管腔,就是自身管腔剔除了斑块后所剩下的血管管腔;所述的斑块负荷是指横截面上的斑块面积与自身管腔的面积的比值;(4)血管三维成像模块,用于对被选择的感兴趣的血管,根据其OCT影像的血管横截面和纵截面影像以及DSA影像分割重建后的血管走形,生成直观的血管三维结构;(5)DSA影像和OCT影像的联动模块,用于根据血管的三维结构,获取所勾勒的血管中心线上的起始点和终末点之间的真实长度,并根据起始点和终末点,确定OCT影像上相应的起始帧和结束帧图像,并计算出OCT影像上起始帧和结束帧之间的图像帧数N,进而自动将DSA影像上的起始点和终末点之间的血管分割成N个等距离的点,实现DSA影像上的血管的每个点对应OCT影像上各自相应的帧图像,并通过对DSA影像的血管分割重建模块所获得的血管测量结果和OCT影像的血管测量模块所获得的横截面上的血管测量结果的对比,方便术者判断是否对病变血管行介入治疗以及介入治疗的血管段位置,进而确定治疗方案,并帮助术者精确选择支架大小和定位支架;(6)影像报告模块,用于根据由计算机自动输入或人工输入的上述模块所获得的中间数据和结果数据,按照模板,生成影像介入检查相关数据报告;(7)传输模块,用于传输一体化在线实时处理仪所生成的影像数据和报告至指定的计算机。 The present invention includes seven modules: data acquisition module, blood vessel segmentation and reconstruction module of DSA image, blood vessel measurement module of OCT image, three-dimensional blood vessel imaging module, linkage module of DSA image and OCT image, image report module and transmission module. Among them: (1) Data acquisition module, including a high-definition acquisition card with two DVI interfaces embedded in the computer, used to collect OCT images and DSA images in real time during the operation, and store them in the local hard disk of the computer; (2) DSA images of blood vessels The segmentation and reconstruction module is used to reconstruct the shape of the blood vessel from the acquired DSA image, draw the center line of the blood vessel for the selected blood vessel segment of interest in the reconstructed blood vessel, and mark the origin of the blood vessel segment of interest on the outlined blood vessel center line The start point and end point; (3) The blood vessel measurement module of the OCT image, using the size of the OCT catheter as a reference, performs automatic or human-computer interactive vascular lumen measurement on the selected image of interest on the OCT image; The fully automatic measurement means that the computer automatically obtains the boundary of the self-lumina and the residual lumen according to the gray value of the boundary of the self-lumina and the residual lumen on the cross-section of the blood vessel, and obtains the measurement result; Human-computer interactive measurement refers to the automatic measurement of the image of interest by the computer, and then provides the operator with a modification interface, receives the operator's instructions, and modifies its own lumen and residual lumen on the cross-section of the blood vessel The blood vessel measurement module of the OCT image performs the measurement according to the newly outlined boundary of the blood vessel lumen. The measurement includes: the lumen area, diameter and plaque load of the self-lumen and residual lumen on the cross-section of the blood vessel, and the length of the blood vessel on the longitudinal section; the self-lumen refers to the original vessel lumen, Including the remaining vascular lumen and plaque; the remnant lumen refers to the existing vascular lumen that can pass through the blood flow, which is the remaining vascular lumen after the plaque is removed from the own lumen; The plaque load refers to the ratio of the plaque area on the cross section to the area of the lumen itself; (4) The three-dimensional blood vessel imaging module is used for the selected blood vessel of interest, according to the blood vessel cross-sectional area of the OCT image Sectional and longitudinal section images and DSA images are segmented and reconstructed to generate an intuitive three-dimensional structure of blood vessels; (5) The linkage module of DSA images and OCT images is used to obtain the outline of the centerline of blood vessels according to the three-dimensional structure of blood vessels The real length between the start point and the end point on the OCT image, and according to the start point and the end point, determine the corresponding start frame and end frame image on the OCT image, and calculate the distance between the start frame and the end frame on the OCT image The number of image frames between is N, and then the blood vessel between the starting point and the end point on the DSA image is automatically divided into N equidistant points, so that each point of the blood vessel on the DSA image corresponds to the corresponding corresponding point on the OCT image Frame images, and by comparing the blood vessel measurement results obtained by the blood vessel segmentation and reconstruction module of the DSA image with the blood vessel measurement results on the cross section obtained by the blood vessel measurement module of the OCT image, it is convenient for the operator to judge whether to perform interventional treatment on the diseased blood vessel And the position of the vessel segment for interventional treatment, so as to determine the treatment plan, and help the operator to accurately select the size of the stent and position the stent; (6) The image report module is used for the intermediate data obtained from the above modules automatically or manually input by the computer and the result data, according to the template, generate the data report related to the image intervention examination; (7) the transmission module, used to transmit the image data and report generated by the integrated online real-time processor to the designated computer.

进一步地,DSA影像的血管分割重建模块基于匹配滤波的方法,提取不相交血管的边缘、直径和中心线,对采集的DSA影像血管重建血管走形。 Furthermore, the blood vessel segmentation and reconstruction module of the DSA image extracts the edges, diameters, and centerlines of disjoint blood vessels based on the matched filtering method, and reconstructs the blood vessel shape from the collected DSA image blood vessels.

进一步地,DSA影像的血管分割重建模块还结合多尺度分析和边界跟踪的方法,提高模糊的、细小的和交叉的血管处理效果。 Furthermore, the vessel segmentation and reconstruction module of DSA images also combines multi-scale analysis and boundary tracking methods to improve the processing effect of blurred, small and intersecting vessels.

进一步地,DSA影像的血管分割重建模块还可以根据指令,以造影导管或指引导管的尺寸做参照,对DSA影像上感兴趣的血管段进行长度、参考直径和管腔面积的测量。 Furthermore, the vessel segmentation and reconstruction module of the DSA image can also measure the length, reference diameter and lumen area of the vessel segment of interest on the DSA image with reference to the size of the contrast catheter or guide catheter according to the instruction.

进一步地,血管三维成像模块在生成血管的三维结构之后,还可以根据指令,通过纵截面上的血管长度和横截面上的残余管腔的面积,获取血管容积。 Further, after generating the three-dimensional structure of the blood vessel, the blood vessel three-dimensional imaging module can also obtain the blood vessel volume according to the length of the blood vessel on the longitudinal section and the area of the residual lumen on the cross section according to the instruction.

所述影像报告模块中所述的“上述模块所获得的中间和结果数据”,可以是某个模块对图像的测量结果和计算结果、某个模块采集的图像、经某个模块处理后的图像。 The "intermediate and result data obtained by the above modules" mentioned in the image report module can be the measurement results and calculation results of images by a certain module, the images collected by a certain module, and the images processed by a certain module .

采用本发明的技术方案,具有以下技术效果: Adopting the technical scheme of the present invention has the following technical effects:

(1)直观获取血管的真实长度、血管管腔直径、血管管腔面积和容积以及斑块负荷;(2)获取直观的血管三维结构;(3)通过对所述的DSA影像的血管分割重建模块所获得的血管测量结果和所述的OCT影像的血管测量模块所获得的横截面上的血管测量结果的对比,方便术者判断是否对病变血管行介入治疗以及介入治疗的血管段位置,进而确定治疗方案,并帮助术者精确选择支架大小和定位支架。 (1) Intuitively obtain the true length of the blood vessel, the diameter of the vascular lumen, the area and volume of the vascular lumen, and the plaque load; (2) Obtain the intuitive three-dimensional structure of the blood vessel; (3) Reconstruct the blood vessel through the segmentation of the DSA image The comparison between the blood vessel measurement results obtained by the module and the cross-sectional blood vessel measurement results obtained by the OCT image blood vessel measurement module is convenient for the operator to judge whether to perform interventional treatment on the diseased blood vessel and the position of the blood vessel segment for the interventional treatment, and then Determine the treatment plan, and help the surgeon to accurately select the size of the stent and position the stent.

附图说明 Description of drawings

图1是本发明系统与其它相关设备的整体结构框架图。 Fig. 1 is a frame diagram of the overall structure of the system of the present invention and other related equipment.

图2是本发明系统的实现方式路线图。 Fig. 2 is a roadmap of the implementation of the system of the present invention.

图中,1、血管内光相干断层扫描仪;2、数字减影血管造影机;3、OCT影像和DSA影像一体化在线实时处理仪;4、影像图片专用打印机;5、医院的影像中央站;6、数据采集模块;7、DSA影像的血管分割重建模块;8、OCT影像的血管测量模块;9、DSA影像和OCT影像的联动模块;10、血管三维成像模块;11、影像报告模块;12、传输模块。 In the figure, 1. Intravascular optical coherence tomography scanner; 2. Digital subtraction angiography machine; 3. Integrated online real-time processor for OCT images and DSA images; 4. Special printer for images; 5. Central image station of the hospital 6. Data collection module; 7. Vessel segmentation and reconstruction module for DSA images; 8. Vessel measurement module for OCT images; 9. Linkage module for DSA images and OCT images; 10. Three-dimensional vascular imaging module; 11. Image report module; 12. Transmission module.

具体实施方式 Detailed ways

根据图1和图2,本发明所提供的是集成血管内光相干断层扫描(OCT)影像和数字减影(DSA)影像的一体化在线实时处理仪。该系统包括七个模块:数据采集模块、DSA影像的血管分割重建模块、OCT影像的血管测量模块、血管三维成像模块、DSA影像和OCT影像联动模块、影像报告模块以及传输模块。其中:(1)数据采集模块:包括在计算机内部嵌入含两路DVI接口的高清采集卡,用于在术中实时采集OCT影像和DSA影像,并存于计算机本地硬盘;(2)DSA影像的血管分割重建模块:基于匹配滤波的方法,在DSA影像上提取不相交血管的边缘、直径和中心线,重建血管走形,结合多尺度分析和边界跟踪的方法,提高模糊的、细小的和交叉的血管处理效果,并对感兴趣的血管勾勒血管中心线,在勾勒的血管中心线上标注兴趣血管段的起始点和终末点,或者,进一步地,根据指令,通过以造影导管或指引导管的尺寸做参照,对DSA影像上感兴趣的血管段进行长度、参考直径和管腔面积的测量;(3)OCT影像的血管测量模块,通过OCT导管的自身尺寸做参照,对OCT影像上被选择的感兴趣的图像进行全自动或人机互动式血管管腔的测量;所述的全自动测量是指计算机根据血管横截面上的自身管腔和残余管腔的边界的灰度值的不同,自动获取自身管腔和残余管腔的边界,并获得测量结果;所述的人机互动式测量是指在计算机对感兴趣的图像进行所述的全自动测量的基础上,再提供操作者修改界面,接收操作者的指令,修改血管横截面上自身管腔和残余管腔的边界,OCT影像的血管测量模块根据新勾勒的血管管腔边界再进行所述测量。所述测量包括:血管横截面上的自身管腔与残余管腔的管腔面积、直径和斑块负荷,以及纵截面上血管的长度;所述的自身管腔是指原始的血管管腔,包括残余的血管管腔和斑块部分;所述的残余管腔是指目前现有的能供血流通过的血管管腔,就是自身管腔剔除了斑块后所剩下的血管管腔;所述的斑块负荷是指横截面上的斑块面积与自身管腔的面积的比值;(4)血管三维成像模块:用于对感兴趣的血管,根据其OCT影像的血管横截面和纵截面影像以及DSA影像分割重建后的血管走形,生成直观的血管三维结构,或者,进一步地,在生成血管的三维结构之后,还可以根据指令,通过纵截面上的血管长度和横截面上的残余管腔的面积,获取血管容积;(5)DSA影像和OCT影像的联动模块:用于根据血管的三维结构,获取所勾勒的血管中心线上的起始点和终末点之间的真实长度,并根据起始点和终末点,确定OCT影像上相应的起始帧和结束帧图像,并计算出OCT影像上起始帧和结束帧之间的图像帧数N,进而自动将DSA影像上的起始点和终末点之间的血管分割成N个等距离的点,实现DSA影像上的血管的每个点对应OCT影像上各自相应的帧图像,并通过对DSA影像的血管分割重建模块所获得的血管测量结果和OCT影像的血管测量模块所获得的横截面上的血管测量结果的对比,方便术者判断是否对病变血管行介入治疗以及介入治疗的血管段位置,进而确定治疗方案,并帮助术者精确选择支架大小和定位支架;(6)影像报告模块:用于根据由计算机自动输入或人工输入的上述模块所获得的测量数值,按照模板,生成影像介入检查相关数据报告;(7)传输模块:用于传输一体化在线实时处理仪所生成的影像数据和报告至指定的计算机。 According to FIG. 1 and FIG. 2 , the present invention provides an integrated online real-time processor that integrates intravascular optical coherence tomography (OCT) images and digital subtraction (DSA) images. The system includes seven modules: data acquisition module, vessel segmentation and reconstruction module for DSA images, vessel measurement module for OCT images, three-dimensional vessel imaging module, DSA image and OCT image linkage module, image report module and transmission module. Among them: (1) Data acquisition module: including a high-definition acquisition card with two DVI interfaces embedded in the computer, which is used to collect OCT images and DSA images in real time during the operation, and store them in the local hard disk of the computer; (2) The blood vessels of DSA images Segmentation and reconstruction module: Based on the matching filtering method, extract the edges, diameters and centerlines of disjoint blood vessels on DSA images, reconstruct the shape of blood vessels, combine multi-scale analysis and boundary tracking methods, and improve blurred, small and crossed The effect of blood vessel processing, and draw the centerline of the blood vessel of interest, mark the starting point and end point of the blood vessel segment of interest on the outline of the blood vessel center line, or, further, according to the instruction, use the angiography catheter or guide catheter The size is used as a reference to measure the length, reference diameter and lumen area of the vessel segment of interest on the DSA image; (3) the blood vessel measurement module of the OCT image is used as a reference by the size of the OCT catheter itself, and is selected on the OCT image The image of interest is used for fully automatic or human-computer interactive measurement of the blood vessel lumen; the fully automatic measurement refers to the computer according to the difference in the gray value of the boundary between the self lumen and the residual lumen on the blood vessel cross section, Automatically obtain the boundaries of its own lumen and residual lumen, and obtain the measurement results; the human-computer interactive measurement refers to the automatic measurement performed by the computer on the image of interest, and then provides the operator with modification The interface receives the instruction from the operator and modifies the boundary between the self-lumina and the residual lumen on the cross-section of the blood vessel, and the blood vessel measurement module of the OCT image performs the measurement according to the newly outlined boundary of the blood vessel lumen. The measurement includes: the lumen area, diameter and plaque load of the self-lumen and residual lumen on the cross-section of the blood vessel, and the length of the blood vessel on the longitudinal section; the self-lumen refers to the original vessel lumen, Including the remaining vascular lumen and plaque; the remnant lumen refers to the existing vascular lumen that can pass through the blood flow, which is the remaining vascular lumen after the plaque is removed from the own lumen; The plaque load refers to the ratio of the plaque area on the cross section to the area of its own lumen; (4) Three-dimensional blood vessel imaging module: used for the blood vessel of interest, according to the blood vessel cross-section and longitudinal image of the OCT image Sectional images and DSA images are segmented and reconstructed to generate an intuitive three-dimensional structure of blood vessels, or, further, after the three-dimensional structure of blood vessels is generated, according to instructions, the length of blood vessels on the longitudinal section and the length of the cross-section on the The area of the residual lumen to obtain the vessel volume; (5) Linkage module of DSA image and OCT image: used to obtain the true length between the starting point and the end point on the centerline of the outlined vessel according to the three-dimensional structure of the vessel , and according to the start point and end point, determine the corresponding start frame and end frame image on the OCT image, and calculate the image frame number N between the start frame and the end frame on the OCT image, and then automatically add the DSA image to The blood vessel between the starting point and the end point of the DSA image is divided into N equidistant points, and each point of the blood vessel on the DSA image corresponds to the corresponding frame image on the OCT image, and the blood vessel segmentation and reconstruction module of the DSA image The comparison between the obtained blood vessel measurement results and the cross-sectional blood vessel measurement results obtained by the OCT image blood vessel measurement module is convenient for the operator to judge whether to perform interventional therapy on the diseased blood vessel and the position of the blood vessel segment for the interventional therapy, and then determine the treatment plan. And help the operator to accurately select the size of the stent and position the stent; (6) Image report module: It is used to generate a data report related to image intervention inspection according to the template according to the measured values obtained by the above modules automatically input by the computer or manually input; 7) Transmission module: used to transmit the image data and reports generated by the integrated online real-time processor to the designated computer.

在做心血管介入手术过程中,一些特殊的病变(如:血栓病变、支架内再狭窄等)往往需要血管内光相干断层扫描检查的指导,此时,本发明将进入运用阶段,其具体的实施步骤如下: In the process of cardiovascular interventional surgery, some special lesions (such as: thrombotic lesions, in-stent restenosis, etc.) often require the guidance of intravascular optical coherence tomography examination. At this time, the present invention will enter the application stage, and its specific The implementation steps are as follows:

1、    将本发明在介入导管室内分别与DSA机器和OCT机器的影像输出接口相连,通过高清数据采集卡,实时获取术中DSA影像和OCT影像; 1. Connect the present invention to the image output interfaces of the DSA machine and the OCT machine respectively in the interventional catheterization room, and obtain intraoperative DSA images and OCT images in real time through the high-definition data acquisition card;

2、通过DSA影像和OCT影像的对比观察,由操作者在DSA影像上找到感兴趣的病变血管,根据操作者指令,由计算机运行,用DSA影像的血管分割重建模块对DSA影像上感兴趣的血管,重建血管走形,并对重建后的血管,勾勒中心线,并自动生成垂直于中心线的可移动线,在中心线上标注感兴趣的病变血管的起始点和终末点。所述的感兴趣的病变血管也即被选择的血管,即本发明的处理对象。 2. Through the comparison and observation of DSA images and OCT images, the operator finds the lesion vessels of interest on the DSA images. According to the operator's instructions, it is run by the computer, and the vessel segmentation and reconstruction module of the DSA images is used to find the interested vessels on the DSA images. Blood vessels, reconstruct the shape of the blood vessels, and outline the centerline of the reconstructed blood vessels, and automatically generate a movable line perpendicular to the center line, and mark the starting point and end point of the diseased blood vessel of interest on the center line. The diseased blood vessel of interest is also the selected blood vessel, which is the processing object of the present invention.

3、根据操作者指令,由计算机运行,根据所选择血管的OCT影像的血管横截面和纵截面影像以及DSA影像分割重建后的血管走形,用血管三维成像模块,生成直观的血管三维结构。 3. According to the instructions of the operator, it is operated by the computer, and according to the vessel cross-section and longitudinal section images of the OCT image of the selected vessel and the vessel shape after segmentation and reconstruction of the DSA image, the three-dimensional vessel imaging module is used to generate an intuitive three-dimensional structure of the vessel.

4、根据操作者指令,由计算机运行,用DSA影像和OCT影像的联动模块,在前述产生的血管三维结构上标出与中心线上的病变血管段的起始点和终末点相对应的起始点和终末点,进而获取两点之间的血管的真实长度;并根据起始点和终末点,确定OCT影像上相应的起始帧和结束帧图像,获取OCT影像上起始帧和结束帧之间的图像帧数N,进而自动将DSA影像上的起始点和终末点之间的血管分割成N个等距离的点,实现DSA影像上的血管的每个点对应OCT影像上各自相应的帧图像。 4. According to the instructions of the operator, run by the computer, use the linkage module of the DSA image and the OCT image to mark the starting point and the ending point of the diseased blood vessel segment on the center line on the three-dimensional structure of the blood vessel generated above. Start point and end point, and then obtain the true length of the blood vessel between the two points; and according to the start point and end point, determine the corresponding start frame and end frame image on the OCT image, and obtain the start frame and end frame on the OCT image The number of image frames between frames is N, and then the blood vessel between the starting point and the end point on the DSA image is automatically divided into N equidistant points, so that each point of the blood vessel on the DSA image corresponds to each point on the OCT image corresponding frame image.

5、选择联动操作后,在DSA影像的被选择的血管上的N个点之间移动可移动线时,OCT影像上的帧图像会相应地前后运动;反之,在OCT影像上的开始帧与结束帧之间前后运动帧图像时,DSA影像上的可移动线会相应移动。进而实现DSA影像和OCT影像的联动,确保可移动线所处的血管段与OCT影像的当前帧图像相吻合,方便术者对DSA影像和OCT影像进行对比观察。 5. After the linkage operation is selected, when the movable line is moved between the N points on the selected blood vessel in the DSA image, the frame images on the OCT image will move back and forth accordingly; otherwise, the start frame on the OCT image and When the frame image is moved back and forth between the end frames, the movable line on the DSA image will move accordingly. Furthermore, the linkage between the DSA image and the OCT image is realized to ensure that the vessel segment where the movable line is located coincides with the current frame image of the OCT image, and it is convenient for the operator to compare and observe the DSA image and the OCT image.

通过DSA影像和OCT影像的联动模块,为在DSA影像和OCT影像的对比处理过程提供了非常直观和方便的界面。通过OCT影像的血管测量模块对感兴趣的血管段进行血管管腔的测量,并通过DSA影像的血管分割重建模块对相应的血管段进行长度、参考直径和血管管腔面积的测量,进而方便术者在血管相同病变处,对比上述两者的测量结果,根据对比结果,判断是否对病变血管行介入治疗以及介入治疗的血管段位置,进而确定治疗方案,并帮助术者精确选择支架大小和定位支架。 Through the linkage module of DSA images and OCT images, a very intuitive and convenient interface is provided for the comparison and processing of DSA images and OCT images. The vascular measurement module of the OCT image is used to measure the vessel lumen of the interested vessel segment, and the length, reference diameter and vessel lumen area of the corresponding vessel segment are measured through the vessel segmentation and reconstruction module of the DSA image, thereby facilitating the operation. The patient compares the measurement results of the above two in the same lesion of the blood vessel, and judges whether to perform interventional therapy on the lesioned blood vessel and the position of the blood vessel segment for the interventional therapy according to the comparison results, so as to determine the treatment plan and help the operator to accurately select the size and location of the stent stand.

6、根据需要,通过血管的三维成像模块,在生成血管三维结构之后,根据指令,通过纵截面上的血管长度和横截面上的残余管腔的面积,获取血管容积。 6. According to the requirement, after the three-dimensional structure of the blood vessel is generated by the three-dimensional imaging module of the blood vessel, the volume of the blood vessel is obtained according to the length of the blood vessel on the longitudinal section and the area of the residual lumen on the cross section according to the instruction.

7、根据操作者指令,由计算机运行,用影像报告模块根据手动输入或计算机自动输入的影像测量数据,生成报告并随测量后的影像,一同用传输模块上传至指定的计算机,以备再次利用。 7. According to the operator's instructions, it is run by the computer, and the image report module is used to generate a report based on the image measurement data input manually or automatically by the computer, and the measured image is uploaded to the designated computer with the transmission module for reuse .

Claims (5)

1. the online processing instrument in real time of the integration of integrated Ink vessel transfusing Optic coherence tomography (OCT) image and Digital Subtraction (DSA) image, comprises with lower module: the blood vessel segmentation of data acquisition module, DSA image rebuilds the interlocking module of module, the vessel measurement module of OCT image, blood vessel three-dimensional imaging module, DSA image and OCT image, image report module and transport module;
Described data acquisition module, is included in computer-internal and embeds the high definition capture card containing two-way DVI interface, for Real-time Collection OCT image in art and DSA image, and be stored in computer local hard drive;
The blood vessel segmentation of described DSA image rebuilds module, for out of shape to the DSA image reconstruction blood vessel gathered, to rebuild after blood vessel in by the interested vessel segment selected, sketch the contours vessel centerline, the vessel centerline sketched the contours mark starting point and the end of the final point of vessel segment;
The vessel measurement module of described OCT image, does reference by the own dimensions of OCT conduit, is carried out measurement that is full-automatic or human-machine interaction vessel lumen on OCT image by the interested image selected; Described all automatic measurement refers to the difference of computer according to the gray value on the border of self tube chamber in vessel cross-sections and remaining tube chamber, the border of automatic acquisition self tube chamber and remaining tube chamber, and obtains measurement result; Described human-machine interaction measurement refers to be carried out on the basis of described all automatic measurement at computer to interested image, reoffer operator and revise interface, receive the instruction of operator, the border of self tube chamber and remaining tube chamber in amendment vessel cross-sections, the vessel measurement module of OCT image carries out described measurement again according to the vessel lumen border of newly sketching the contours; Described measurement comprises: self tube chamber in vessel cross-sections and the Lumen Area of remaining tube chamber, diameter and plaque load, and the length of blood vessel on longitudinal section; Self described tube chamber refers to original vessel lumen, comprises remaining vessel lumen and plaque components; Described remaining tube chamber refers to the vessel lumen that the blood supply of current existing energy flows through, and is exactly vessel lumen remaining after self tube chamber eliminates speckle; Described plaque load refers to the ratio of the area of plaque area on cross section and self tube chamber;
Described blood vessel three-dimensional imaging module, for by the interested blood vessel selected, the blood vessel after rebuilding according to the vessel cross-sections of its OCT image and longitudinal section image and DSA Image Segmentation is out of shape, generates blood vessel three dimensional structure intuitively;
Described DSA image and the interlocking module of OCT image, for the three dimensional structure according to blood vessel, starting point in the vessel centerline that acquisition is sketched the contours and the actual length between end of the final point, and according to starting point and end of the final point, determine corresponding start frame and end frame image on OCT image, and the number of image frames N calculated on OCT image between start frame and end frame, and then automatically the blood vessel segmentation between the starting point on DSA image and end of the final point is become N number of equidistant point, corresponding two field picture separately on the corresponding OCT image of each point realizing the blood vessel on DSA image, facilitate the accurate measurement of vessel lumen and the accurate location of support,
Described image report module, the intermediate data obtained for the interlocking module rebuilding module, the vessel measurement module of OCT image, blood vessel three-dimensional imaging module, DSA image and OCT image according to the blood vessel segmentation of the data acquisition module automatically being inputted by computer or manually input, DSA image and result data, according to template, generate image and get involved the report of inspection related data;
Described transport module, for transmitting image data and report that the online processing instrument in real time of integration generates to the computer of specifying.
2. the online processing instrument in real time of integration as claimed in claim 1, it is characterized in that the blood vessel segmentation of described DSA image rebuilds the method for module based on matched filtering, extract the edge of non-intersect blood vessel, diameter and centrage, out of shape to the DSA image reconstruction blood vessel collected.
3. the online processing instrument in real time of integration as claimed in claim 2, is characterized in that the blood vessel segmentation of described DSA image rebuilds module also in conjunction with the method for multiscale analysis and frontier tracing, improves fuzzy, tiny of the management of blood vessels effect of intersecting.
4. the online processing instrument in real time of integration as claimed in claim 2 or claim 3, it is characterized in that the blood vessel segmentation of described DSA image rebuilds module also according to instruction, do reference with the size of angiography catheter or guiding catheter, vessel segment interested on DSA image is carried out to the measurement of length, reference diameter and Lumen Area.
5. the online processing instrument in real time of integration as claimed in claim 1, it is characterized in that described blood vessel three-dimensional imaging module, after the three dimensional structure generating blood vessel, also according to the area of instruction by the remaining tube chamber on the length of vessel on longitudinal section and cross section, obtain capacity of blood vessel.
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