CN103316249B - Astragalus taxus chinensis capsule and preparing process thereof - Google Patents
Astragalus taxus chinensis capsule and preparing process thereof Download PDFInfo
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- CN103316249B CN103316249B CN201210079847.4A CN201210079847A CN103316249B CN 103316249 B CN103316249 B CN 103316249B CN 201210079847 A CN201210079847 A CN 201210079847A CN 103316249 B CN103316249 B CN 103316249B
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Abstract
The invention discloses an astragalus taxus chinensis capsule and a preparing process thereof. The Chinese medicine preparation is prepared from astragalus, taxus chinensis, codonopsis pilosula, atractylodes, scutellaria barbata, hedyotis diffusa, panax notoginseng, fructus citrus sarcodactylis, pinellia ternata, semen coicis, Chinese thorowax, fritillaria cirrhosa and poria cocos. The preparing process comprises: step one, crushing panax notoginseng and fritillaria cirrhosa into a fine powder; step two, adding 10 times the amount of water into the other medicinal materials, decocting and extracting for 2 times, performing a first decoction for 2 hours and a second decoction for 1.5 hours, filtering respectively, and merging the two extracts; step three, heating to concentrate the merged extract obtained in the step two into a clear plaster, drying under a reduced pressure and crushing into a fine powder, and mixing uniformly the fine powder with the fine powder of the step one to form a mixture A; and then pelletizing the mixture A, and performing capsulation. The Chinese medicine preparation provided by the invention is safe and reliable, has no toxic or side effect, mainly cures lung cancer and toxic or side effects of radiotherapy and chemotherapy of the lung cancer, can enhance body immunity, promotes apoptosis of lung cancer cells, can improve patient life quality, and plays a prolonging role in patient life time.
Description
Technical field
The present invention relates to a kind of stilbene China fir capsule and preparation technology thereof.
Background technology
The etiology and pathogenesis of pulmonary carcinoma is mainly because natural endowment is not enough, and healthy energy is deficient, function generation obstacle, body is defended outer unable, outer by evil poison, lung yin of burning, therefore ascending or descending movement of vital Qi is not normal, and blood is obstructed, and forms long-pending block.Or because of exopathogen internal injury, cause negative and positive to lose, spleen insufficiency, the internal organs imbalance of YIN and YANG such as deficiency of kidney-QI, and cause lung qi imbalance, mechanism of qi does not relax, hematogenous blockage, stagnantly forms tumor.Or because of impaired depurative descending of lung QI, logical tune mistake department, spleen loses transporting, and stop in turbid damp, phlegm-damp is tied mutually, is jammed in lung, and then phlegm-damp condenses and forms lump for a long time.Or because of evil poison (as six climate exopathogens) invasion and attack, obstruction of lung-QI, mistake department falls in a surname, and lung network is not smooth, and qi depression to blood stasis, becomes carcinoma.To sum up discuss, think that the etiology and pathogenesis of primary disease is mainly because healthy energy is deficient, imbalance of YIN and YANG, function generation obstacle, Abwehrkraft des Koepers is reduced, and pathogen attacks lung in an opponent's defence, bridle of a specified duration is not dispelled, and dysfunction of the spleen in transportation falls mistake department, in a surname, lung qi Yu Ze disorder of QI movement, channels is obstructed, and blood stagnates, insufficiency of the spleen wet then poly-essence of accumulateing is expectorant, the stagnation of QI, blood stasis, expectorant coagulates, and pyretic toxicity is cemented in lung, with the passing of time forms long-pending block and is lung tumors.Visible pulmonary carcinoma is one and falls ill because of empty, causes reality because of empty, and whole body belongs to empty, the disease that local is true.Its disease being located in the lung, dirty in close relations with spleen, kidney two.If mistake is controlled, wrong treatment, then cause internal organs QI and blood function void and decline, then the heresy of expectorant, poison can be fled in an opponent's defence and be stranded in the places such as bone, internal organs, brains, then do not control also.Pulmonary carcinoma is systemic disease, and the tumor of pulmonary is a topical manifestations of whole body, because void is fallen ill, and excess caused by deficiency; Whole body is empty, and local is true; Void is disease basis, is the mark of disease in fact.The morbidity of pulmonary carcinoma mostly is middle-older patient, weak and sickly, prolonged illness impairment caused by overstrain, and in insufficiency of lung-QI, cloudy liquid is short; Exopathogen attacks lung in an opponent's defence, and poison is accumulate in heat-transformation, more cloudy Tianjin of impairing the lung.
Medical science is thought, " healthy energy deposit in, heresy can not be done ", " gathering of heresy; its gas must be empty ", the formation of human tumor and growth course be in body just, the process of evil struggle growth and decline, thinking the void of pulmonary carcinoma, is basic pathological change with the deficiency of YIN, the deficiency of vital energy, clinical manifestation to cough, to breathe heavily, pain, therefore vertical supplementing QI and nourishing YIN, moistening the lung and resolving phlegm, loose long-pending note of the ancient Chinese that disappears is method.
Summary of the invention
The present invention is directed to the core pathogenesis of pulmonary carcinoma " insufficiency of the spleen mistake is good for; weakened body resistance poison knot ", with " strengthening vital QI to eliminate pathogenic factors, reinforcement and elimination in combination " for the principles of formulating prescriptions, provide a kind of stilbene China fir capsule and preparation technology thereof, its compatibility is simple, evident in efficacy, safe and reliable and have no side effect, and mainly curing cancer of lung and chemicotherapy toxicity thereof, have enhancing human body immunity power, supplementing QI and nourishing YIN, moistening the lung and resolving phlegm, loose long-pending note of the ancient Chinese that disappears, improves the life quality of patient, extends the effect of survival of patients phase.
In the present invention, stilbene China fir capsule is made up of 110 ~ 140 parts of Radixs Astragali, 10 ~ 30 parts of Ramulus et folium taxi cuspidatae, 15 ~ 40 parts of Radix Codonopsis, 60 ~ 90 parts of Rhizoma Atractylodis Macrocephalaes, 60 ~ 90 parts of Herba Scutellariae Barbataes, 60 ~ 90 parts of Herba Hedyotidis Diffusaes, 15 ~ 40 parts of Radix Notoginseng, 60 ~ 90 parts of Fructus Citri Sarcodactylis, 15 ~ 40 parts of Rhizoma Pinelliaes, 60 ~ 90 parts of Semen Coiciss, 15 ~ 40 parts of Radix Bupleuri, 15 ~ 40 parts of Bulbus Fritillariae Cirrhosaes and 60 ~ 90 parts of Poria by ratio of quality and the number of copies.
The preparation technology of stilbene China fir capsule of the present invention is as follows: step one: take 110 ~ 140 parts of Radixs Astragali, 10 ~ 30 portions of Ramulus et folium taxi cuspidatae, 15 ~ 40 parts of Radix Codonopsis, 60 ~ 90 parts of Rhizoma Atractylodis Macrocephalaes, 60 ~ 90 portions of Herba Scutellariae Barbataes, 60 ~ 90 parts of Herba Hedyotidis Diffusaes, 15 ~ 40 portions of Radix Notoginseng, 60 ~ 90 portions of Fructus Citri Sarcodactylis, 15 ~ 40 parts of Rhizoma Pinelliaes, 60 ~ 90 parts of Semen Coiciss, 15 ~ 40 parts of Radix Bupleuri, 15 ~ 40 parts of Bulbus Fritillariae Cirrhosaes and 60 ~ 90 parts of Poria respectively by ratio of quality and the number of copies, then Radix Notoginseng, Bulbus Fritillariae Cirrhosae powder are broken into fine powder, cross 80 mesh sieves;
Step 2: all the other medical materials are added 10 times amount water boiling and extraction 2 times, 2 hours first times, second time 1.5 hours, filters respectively, merges extracted twice liquid;
Step 3: extracting solution heating step 2 obtained is concentrated into the clear paste that relative density is 1.15 ~ 1.25, and heat surveys 80 DEG C; Then, be ground into fine powder after drying under reduced pressure, cross 80 mesh sieves, mix obtained mixture A with fine powder in step one; Again mixture A is granulated, encapsulated, to obtain final product.
In the present invention, mixture A in step 3 can be crossed 8 mesh sieves and granulate, Co60 radiation sterilization, incapsulates, every capsules 0.4g/ grain.
Chinese medicine preparation good effect of the present invention, cure rate be high, not containing noxious substance, have no side effect, and by clinical use, has significant curative effect to pulmonary carcinoma and chemicotherapy toxicity, can control cancerous cell diffusion.Short treating period of the present invention, health.Chinese medicine preparation of the present invention can incapsulate interior use, easy to carry.Cure rate 86.7% of the present invention; Effective percentage is 100%.
The preparation method of Chinese medicine preparation of the present invention is simple, can ensure that medical material active ingredient is not destroyed, medicine long shelf-life.
Chinese crude drug of the present invention:
The Radix Astragali---function cures mainly: raw use: benefit defends consolidating superficial resistance, inducing diuresis to remove edema, poison holding, granulation promoting.Control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle burst or burst do not hold back for a long time.Process use: invigorating the spleen and replenishing QI.Control internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, and the disease of all weakness of QI blood deficiency.
Ramulus et folium taxi cuspidatae---function cures mainly: inducing diuresis to remove edema, treatment nephropathy, diabetes, nephritis edema, dysuria, gonorrhea etc.The kidney warming stimulates the menstrual flow, treat menoxenia, postnatal blood stasis, dysmenorrhea wait until effective effect.
Radix Codonopsis---function cures mainly: for deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, and dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
The Rhizoma Atractylodis Macrocephalae---function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Herba Scutellariae Barbatae---function cures mainly: diuretic, detumescence, removing toxic substances.Harness the Yellow River subcutaneous ulcer, bronchitis, cirrhotic ascites, edema, expand, have loose bowels, dysentery, snakebite, honeybee sting, carbuncle furuncle, toxic swelling, eczema, tinea disease, osteopatia sprain swell and ache.
Herba Hedyotidis Diffusae---function cures mainly: heat-clearing and toxic substances removing, dampness removing.Main dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, cancerous protuberance.
Radix Notoginseng---function cures mainly: hemostasis, dissipating blood stasis, detumescence, pain relieving.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain.
Fructus Citri Sarcodactylis---function cures mainly: liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.
The Rhizoma Pinelliae---function cures mainly: the pungent loose warm-dryness syndrome of this product is poisonous, main enter taste double enter lung, water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.Both cure mainly the abundant expectoration cough with asthma QI rising in reverse order of spleen damp-phlegm heap soil or fertilizer over and around the roots, control again the dizzy palpitation and insomnia that damp-phlegm is violated, also can control wind-phlegm and tell inverse, headache limb fiber crops, hemiplegia, the diseases such as facial hemiparalysis.
Semen Coicis---function cures mainly: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.Semen Coicis can be used for treatment edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen.
Radix Bupleuri---function cures mainly: evacuate and bring down a fever, yang invigorating soothing liver-QI.Cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.
Bulbus Fritillariae Cirrhosae---function cures mainly: lung moistening eliminating stagnation, antitussive reduce phlegm.Control cough due to consumptive disease, spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, scrofula, sore throat, acute mastitis.
Poria---function cures mainly: dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.
Beneficial effect before this: Chinese medicine preparation of the present invention, on the basis of former decoction, is developed into capsule in conjunction with modern preparation technology, saves clinical efficacy and the application characteristic of former square preparation, makes clinical practice convenient, easy to patients.
Preparation technology of the present invention is according to the effective ingredient of ingredients and physicochemical property thereof, and in conjunction with clinical practice and modern preparation technology, enrichment concentrates active ingredient, guarantees the effectiveness of clinical practice.
Accompanying drawing explanation
Fig. 1 is the process flow diagram of Chinese medicine preparation of the present invention.
Detailed description of the invention
Detailed description of the invention one: present embodiment stilbene China fir capsule is made up of 110 ~ 140 parts of Radixs Astragali, 10 ~ 30 parts of Ramulus et folium taxi cuspidatae, 15 ~ 40 parts of Radix Codonopsis, 60 ~ 90 parts of Rhizoma Atractylodis Macrocephalaes, 60 ~ 90 parts of Herba Scutellariae Barbataes, 60 ~ 90 parts of Herba Hedyotidis Diffusaes, 15 ~ 40 parts of Radix Notoginseng, 60 ~ 90 parts of Fructus Citri Sarcodactylis, 15 ~ 40 parts of Rhizoma Pinelliaes, 60 ~ 90 parts of Semen Coiciss, 15 ~ 40 parts of Radix Bupleuri, 15 ~ 40 parts of Bulbus Fritillariae Cirrhosaes and 60 ~ 90 parts of Poria by ratio of quality and the number of copies.
The stilbene China fir capsule of present embodiment, for oral administration, every day three times, each 4 ~ 62 months is 1 course for the treatment of.Anemia of pregnant woman is cautious use of.
In present embodiment, Radix Astragali sweet in the mouth is warm in nature, returns lung, spleen, liver, kidney channel, invigorating QI to consolidate the body surface resistance, inducing diuresis to remove edema, Compendium of Material Medica: " Radix Astragali had both mended three Jiao, defended gas in fact, and with Gui Tonggong, special than Gui Ganping, not hot is different ear.But osmanthus is promoting blood circulation then, can removing blood stasis and real defend gas, over sixty years of age, then QI invigorating was also.The Radix Astragali and Radix Ginseng, Radix Glycyrrhizae three taste again, for removing the panacea scorching, flesh is warm.Taste one are empty, and lung qi first absolutely, must be used Radix Astragali temperature boundary between muscles, beneficial fur, real space between skin and muscles, not make sweating, mend three Jiao with beneficial vigour "." Japan hanako materia medica " is recorded: " help gas strengthening bone and muscle, put on flesh and enrich blood ".
Ramulus et folium taxi cuspidatae is the natural rare plants for anticancer of generally acknowledging in the world.Effect the kidney warming, stimulate the menstrual flow, diuresis, removing toxic substances, eliminating stagnation.Ramulus et folium taxi cuspidatae has distribution in Forest Area In Heilongjiang Province more, and its leaf conventional among the people, root, skin treat pernicious skin infection, multiplex with various oncotherapy in clinical.
Upper two taste Chinese medicines are monarch, the meaning of outstanding strengthening vital QI to eliminate pathogenic factors, and one mends one attacks, and the Radix Astragali is mended and do not stay heresy, and Ramulus et folium taxi cuspidatae is attacked and just do not hinder, and establish we and attack the basis that benefit has both.
Radix Codonopsis sweet in the mouth, property is flat, micro-acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst." must book on Chinese herbal medicine be joined ": " upper Radix Codonopsis, obtain Radix Astragali and defend in fact, join Semen Nelumbinis dysentery relieving, monarch's Radix Angelicae Sinensis is invigorated blood circulation, the reinforcing the heart of assistant Semen Ziziphi Spinosae ".Book on Chinese herbal medicine justice: " gas in tendon fortune, this is very mutually not far away with Radix Ginseng for Radix Codonopsis power energy spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting.Its outstanding valuable person, then spleen invigorating fortune and not dry, grow stomach-Yin and not wetting, lung moistening and do not violate cold and cool, nourishes blood and partially do not grow greasy, inspiring clear sun, gas in vibration, and without just dry fraud.”
Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, warm in nature, return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration.For the key medicine of spleen reinforcing, " Japan hanako materia medica ": " control a wind cutting disease, five kinds of strain and seven kinds of impairment, cold air abdominal distention, mend waist knee joint, expectorant, gas of harnessing the river, diuresis, only regurgitation vomiting, and muscles and bones is weak soft, accumulation of phlegm in the hypochondrium air parcel, Fu Renleng, lump in the abdomen, Wen Ji, epidemic pathogenic factors from mountains, relieving restlessness, longue ".Materia Medica of Decoction: " temperature, sweet in the mouth.Bitter and sweet temperature, rich gas is thin, and cloudy middle-jiao yang, function of the spleen and stomach is also, nontoxic.To start with the sun, shaoyin channel, bright, lunar, few cloudy, cloudy four warps of fainting of foot sun ".Wind between skin controlled by the multiplex Rhizoma Atractylodis Macrocephalae, and hidroschesis disappears painful abdominal mass, mends in harmonization of the stomach, blood between sharp waist umbilicus, waterway, upper and fur, in and heart stomach, lower and waist umbilicus, at the main gas of gas, at the main blood of blood.
Herba Scutellariae Barbatae acrid in the mouth, hardship, cold in nature.Return lung, liver, kidney channel.Function with cure mainly heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice etc., and " medicine mirror pick up any lost article from the road tax " records " Herba mesonae chinensis of Herba Portulacae Grandiflorae solution snakebite ".
Herba Hedyotidis Diffusae bitter but sweet flavor is cold in nature, enters the heart, liver, spleen, large intestine channel, heat-clearing and toxic substances removing, dampness removing.Main dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, cancerous protuberance etc." Guangxi Chinese medicinal herbal ": " control infantile malnutrition, venom, cancerous protuberance.External treatment BAIPAO skin ulcer, Serpentis impetigo "." the south of Fujian Province traditional herbal medicine ": " heat-clearing and toxic substances removing, anti-inflammatory analgetic." " Quanzhou book on Chinese herbal medicine ": " heat clearing away dissipating blood stasis, eliminating carbuncle detoxifies.Control ulcer sores, scrofula.Again can lung heat clearing fire, eliminating the pathogens from the lung heat.Control lung-heat dyspnea with rapid and short breath, cough against uncomfortable in chest ".
Above four is ministerial drug altogether, impels our righting, eliminating evil power stronger.Wherein, Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, Herba Scutellariae Barbatae heat-clearing and toxic substances removing, blood stasis dispelling diuresis, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, dampness removing, the former two and the Radix Astragali share that the power that can make Radix Astragali invigorating QI to consolidate the body surface resistance is stronger, and the latter two share compatibility Ramulus et folium taxi cuspidatae, can the power of Shiization Disorder eliminating stagnation stronger.
Radix Notoginseng is warm in nature, sweet in the mouth, micro-hardship, returns liver, stomach warp, hemostasis, dissipating blood stasis, detumescence, pain relieving.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, the hemorrhagic conditions such as metrorrhagia, and lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain etc.Compendium of Material Medica cloud: " pseudo-ginseng hemostatic, loose blood, analgesic therapy "." Compendium of Materia Medica is newly organized ": " Radix Notoginseng, the refreshing medicine of hemostasis also.The no matter blood of upper, middle and lower, all have outer more person, privately simply also imitates, and is incorporated in rich in nutrition medicine then more refreshing.Cover this medicine must to mend and without the trouble of boiling, mend red this and have peace and quiet not also "." book on Chinese herbal medicine is looked for the truth " " Radix Notoginseng, common people only know function hemostasis and pain-relieving.Hardly realize that pain aches work because of blood stasis, because applying loose, blood stops blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient, can in its blood stasis of blood systemization ".
Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade." Japan hanako materia medica ": " mend five kinds of strain and seven kinds of impairment, antiabortive, warm waist knee joint, happy Fructus Alpiniae Oxyphyllae, only forgetful "." book on Chinese herbal medicine justice ": " Poria, can dry by sharp key, and sharp key is happy Fructus Alpiniae Oxyphyllae then, leads turbid promoting the production of body fluid; Dry, dry spleen of relieving oedema or abdominal distension through diuresis or purgation, invigorating middle warmer stomach invigorating; Dispel infantile convulsion, thick intestinal is hidden, control expectorant this, help falling of medicine.
Semen Coicis sweet in the mouth, light, cool in nature, invigorating spleen for diuresis removing dampness, wind-damp dispelling, clearing away damp-heat, wet effect of reducing phlegm.Still there is relieving restlessness of calming the nerves, the merit of removing toxic substances.Shennong's Herbal: " taking QI invigorating of making light of one's life by commiting suicide for a long time ", Compendium of Material Medica meaning Semen Coicis " skin care is stayed appearance, made light of one's life by commiting suicide and prolong life for invigorating spleen and reinforcing stomach, tonifying the lung heat clearing away, expelling wind and dampness "." Elementary Medicine ": " Your Majesty's gas, ambition first is wrong " " property of medicine opinion ": " the small stream poison fifth day of the first lunar month of decoction is swollen ".
Fructus Citri Sarcodactylis acrid in the mouth, micro-hardship, warm in nature.Energy soothing liver-QI for relieving depression, regulating the flow of Qi and the middle Jiao, reduces phlegm.For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium; Stagnation of QI in spleen and stomach, abdominal distention, vomiting is eaten less; Cough with copious phlegm." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold syndrome of the stomach that disappears expectorant, controls gastric qi pain for tonifying liver warming the stomach, anti-nausea, the only cold pain in face, and middle circulation of qi promoting." Compendium of Material Medica: " boil beverage, control mental disorder cough.Decoct soup, control pain due to disorder of QI under the heart ".
Rhizoma Pinelliae acrid in the mouth, warm in nature, enter spleen, stomach warp, water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass." herbal classic ": " main typhoid fever cold and heat, hardness in the epigastrium, the therapeutic method to keep the adverse QI flowing downwards, laryngopharynx swells and ache, and dizziness breast is swollen, cough with dyspnea, borborygmus, hidroschesis "." property of medicine opinion ": expectorant saliva, appetite promoting and the spleen strengthening, anti-nausea, go expectorant in the heart full, lower lung qi, master coughs knot.
Bulbus Fritillariae Cirrhosae is cool in nature, Gan Ping, enters lung meridian, stomach warp, nourishing the lung to arrest cough resolving phlegm and relieving asthma, removing heat-phlegm, begins to be loaded in the Ming Dynasty " the southern regions of the Yunnan Province book on Chinese herbal medicine ".
All medicines share above, spleen invigorating circulation of qi promoting, drying dampness to eliminate phlegm, hold concurrently and are not just hindering with blood stasis dispelling, all repeatedly diseases of solution hepatocarcinoma that can be fabulous.
Radix Bupleuri nature and flavor hardship is flat, enters liver, gallbladder meridian, reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse." property of medicine opinion " " shoulder and back ache, declares smooth vim and vigour, tired weakness and emaciation for Zhi Relao arthralgia with restlessness, steam; The main therapeutic method to keep the adverse QI flowing downwards helps digestion, and time main, in disease, exterior-heat is not understood ", " four tones of standard Chinese pronunciation book on Chinese herbal medicine ": " in main expectorant billows, the breast side of body painful abdominal mass "; " detailed outline ": " control yang-energy to sink, suppressing the hyperactive liver, gallbladder, three burnt, envelope is mutually fiery, and headache, dizzy, blurred vision, swelling pain are hidden from view, deaf ring, all malarias, and lump at the left hypochondrium cold and heat, married woman's invasion of the blood-chamber by heat, irregular menstruation, children's's varioliform exanthema waste heat, the thin heat of five kinds of child malnutrition ".Radix Bupleuri enters liver and gall, is the key medicine of depressed liver-energy dispersing and QI regulating, and is the guiding drug of liver and gall warp, " medicine origin ": " Radix Bupleuri lacks sun, faints cloudy guiding drug also ".Radix Bupleuri solution the exterior and the interior, adjusts smooth inside and outside mechanism of qi, not only draws the through sick institute producing " the cancer poison of spleen " of all medicines, adjusts mechanism of qi inside and outside smooth whole body simultaneously, is beneficial to the stasis of blood, heresy, expectorant, the different pathogenic factor such as wet dissolving and get together together, makes medicine for we.
Detailed description of the invention two: present embodiment stilbene China fir capsule is made up of 115 ~ 135 parts of Radixs Astragali, 12 ~ 28 parts of Ramulus et folium taxi cuspidatae, 17 ~ 38 parts of Radix Codonopsis, 63 ~ 88 parts of Rhizoma Atractylodis Macrocephalaes, 63 ~ 88 parts of Herba Scutellariae Barbataes, 63 ~ 88 parts of Herba Hedyotidis Diffusaes, 17 ~ 38 parts of Radix Notoginseng, 63 ~ 88 parts of Fructus Citri Sarcodactylis, 17 ~ 35 parts of Rhizoma Pinelliaes, 63 ~ 88 parts of Semen Coiciss, 17 ~ 38 parts of Radix Bupleuri, 17 ~ 38 parts of Bulbus Fritillariae Cirrhosaes and 63 ~ 88 parts of Poria by ratio of weight and the number of copies.
Detailed description of the invention three: present embodiment stilbene China fir capsule is made up of 120 ~ 135 parts of Radixs Astragali, 15 ~ 25 parts of Ramulus et folium taxi cuspidatae, 20 ~ 35 parts of Radix Codonopsis, 70 ~ 85 parts of Rhizoma Atractylodis Macrocephalaes, 70 ~ 85 parts of Herba Scutellariae Barbataes, 70 ~ 85 parts of Herba Hedyotidis Diffusaes, 20 ~ 35 parts of Radix Notoginseng, 70 ~ 85 parts of Fructus Citri Sarcodactylis, 20 ~ 35 parts of Rhizoma Pinelliaes, 70 ~ 85 parts of Semen Coiciss, 20 ~ 35 parts of Radix Bupleuri, 20 ~ 35 parts of Bulbus Fritillariae Cirrhosaes and 70 ~ 85 parts of Poria by ratio of weight and the number of copies.
Detailed description of the invention four: present embodiment stilbene China fir capsule is made up of 130 parts of Radixs Astragali, 20 parts of Ramulus et folium taxi cuspidatae, 26 parts of Radix Codonopsis, 78 parts of Rhizoma Atractylodis Macrocephalaes, 78 parts of Herba Scutellariae Barbataes, 78 parts of Herba Hedyotidis Diffusaes, 26 parts of Radix Notoginseng, 78 parts of Fructus Citri Sarcodactylis, 26 parts of Rhizoma Pinelliaes, 78 parts of Semen Coiciss, 26 parts of Radix Bupleuri, 26 parts of Bulbus Fritillariae Cirrhosaes and 78 parts of Poria by ratio of weight and the number of copies.
Detailed description of the invention five: the preparation technology of present embodiment stilbene China fir capsule is as follows:
Step one: take 110 ~ 140 parts of Radixs Astragali, 10 ~ 30 portions of Ramulus et folium taxi cuspidatae, 15 ~ 40 parts of Radix Codonopsis, 60 ~ 90 parts of Rhizoma Atractylodis Macrocephalaes, 60 ~ 90 portions of Herba Scutellariae Barbataes, 60 ~ 90 parts of Herba Hedyotidis Diffusaes, 15 ~ 40 portions of Radix Notoginseng, 60 ~ 90 portions of Fructus Citri Sarcodactylis, 15 ~ 40 parts of Rhizoma Pinelliaes, 60 ~ 90 parts of Semen Coiciss, 15 ~ 40 parts of Radix Bupleuri, 15 ~ 40 parts of Bulbus Fritillariae Cirrhosaes and 60 ~ 90 parts of Poria respectively by ratio of quality and the number of copies, then Radix Notoginseng, Bulbus Fritillariae Cirrhosae powder are broken into fine powder, cross 80 mesh sieves;
Step 2: all the other medical materials are added 10 times amount water boiling and extraction 2 times, 2 hours first times, second time 1.5 hours, filters respectively, merges extracted twice liquid;
Step 3: extracting solution heating step 2 obtained is concentrated into the clear paste that relative density is 1.15 ~ 1.25, and heat surveys 80 DEG C; Then, be ground into fine powder after drying under reduced pressure, cross 80 mesh sieves, mix obtained mixture A with fine powder in step one; Again mixture A is granulated, encapsulated, to obtain final product.
Chinese medicine preparation good effect of the present invention, cure rate be high, not containing noxious substance, have no side effect, and by clinical use, has significant curative effect, short treating period of the present invention, health to pulmonary carcinoma and chemicotherapy toxicity.
Chinese medicine preparation of the present invention can incapsulate interior use, easy to carry.Cure rate 86.7% of the present invention; Effective percentage is 100%.
Pharmacodynamics is summarized:
1, the standard of case selection:
Stochastic choice clinical manifestation is discussed and is divided into six kinds of pulmonary carcinosis patients totally 30 people, wherein minimum 36 years old of age, maximum 73 years old, 50 years old mean age.The shortest three months of the course of disease, the longest 5 years.Wherein 28 people have treatment history.
2, the diagnostic criteria of disease
The symptoms such as main manifestations cough, hemoptysis, chest pain, tachypnea, heating.
3, administrated method:
Chinese medicine preparation of the present invention, for oral administration, every day three times, each 4 ~ 62 months is 1 course for the treatment of.
4, medication composition:
130 parts of Radixs Astragali, 20 portions of Ramulus et folium taxi cuspidatae, 26 parts of Radix Codonopsis, 78 parts of Rhizoma Atractylodis Macrocephalaes, 78 portions of Herba Scutellariae Barbataes, 78 parts of Herba Hedyotidis Diffusaes, 26 portions of Radix Notoginseng, 78 portions of Fructus Citri Sarcodactylis, 26 parts of Rhizoma Pinelliaes, 78 parts of Semen Coiciss, 26 parts of Radix Bupleuri, 26 parts of Bulbus Fritillariae Cirrhosaes and 78 parts of Poria.
5, the criterion of curative effect:
1. cure: transference cure recovery from illness does not rebound, and symptom Continuous Observation half a year is without recidivist;
2. effective: symptom obviously disappears;
3. effective: symptom is improved, and other objective determinations take an evident turn for the better;
4. invalid: symptom and objective determination without improvement, or only have short-term to improve.
6, efficacy result analysis:
Table 1 to 30 example the ages 36-73 year pulmonary carcinoma sufferer treat, condition-inference accepts and believe the survey report that regular hospital provides.
Table 1 (unit: people)
| Sequence number | Age | Sex | Disease or symptom | Medication (course for the treatment of) | Therapeutic effect |
| 1 | 45 | Man | Low grade fever | 1 | Cure |
| 2 | 42 | Female | Low grade fever | 1 | Cure |
| 3 | 36 | Man | Low grade fever | 2 | Cure |
| 4 | 39 | Man | Low grade fever | 2 | Cure |
| 5 | 38 | Man | Low grade fever | 1 | Cure |
| 6 | 56 | Female | Cough, spitting of blood | 1 | Cure |
| 7 | 60 | Man | Cough, spitting of blood | 3 | Effectively |
| 8 | 48 | Man | Cough, spitting of blood | 1 | Cure |
| 9 | 60 | Female | Cough, spitting of blood | 3 | Effectively |
| 10 | 58 | Female | Cough, spitting of blood | 2 | Cure |
| 11 | 49 | Man | Chest pain | 2 | Cure |
| 12 | 49 | Female | Chest pain | 1 | Cure |
| 13 | 50 | Man | Chest pain | 1 | Cure |
| 14 | 56 | Female | Chest pain | 2 | Cure |
| 15 | 44 | Man | Chest pain | 1 | Cure |
| 16 | 48 | Man | Tachypnea, hydrothorax | 3 | Cure |
| 17 | 44 | Man | Tachypnea, hydrothorax | 1 | Cure |
| 18 | 38 | Female | Tachypnea, hydrothorax | 1 | Cure |
| 19 | 58 | Man | Tachypnea, hydrothorax | 3 | Cure |
| 20 | 54 | Man | Tachypnea, hydrothorax | 1 | Cure |
| 21 | 55 | Man | Tachypnea, hydrothorax | 1 | Cure |
| 22 | 51 | Man | Heating | 1 | Cure |
| 23 | 49 | Man | Heating | 1 | Cure |
| 24 | 53 | Man | Heating | 1 | Cure |
| 25 | 53 | Female | Heating | 2 | Cure |
| 26 | 73 | Man | Heating | 2 | Effectively |
| 27 | 49 | Man | Breathe hard, weak | 3 | Cure |
| 28 | 47 | Female | Breathe hard, weak | 2 | Cure |
| 29 | 62 | Female | Breathe hard, weak | 1 | Effectively |
| 30 | 42 | Man | Breathe hard, weak | 1 | Cure |
After 1-3 the course for the treatment of, cure 26 people, account for 86.7%; Effective percentage is 100%.
Through clinical proof, take the body constitution that said preparation obviously can strengthen patient, appetite obviously strengthens, anti-cancer dispersing tumor, and long-term taking can suppress and prevent cytopathy, strengthens immune function of human body, and is free from side effects.
Chinese medicine preparation good effect of the present invention, cure rate be high, not containing noxious substance, have enhancing human body immunity power, supplementing QI and nourishing YIN, moistening the lung and resolving phlegm, and loose long-pending note of the ancient Chinese that disappears, can control cancerous cell diffusion, the effect improve the life quality of patient, extending life cycle.
Certainly, above-mentioned explanation is not limitation of the present invention, and the present invention is also not limited in above-mentioned citing, and the change that those skilled in the art make in essential scope of the present invention, remodeling, interpolation or replacement also should belong to protection scope of the present invention.
Claims (7)
1. a stilbene China fir capsule, is characterized in that being made up of 110 ~ 140 parts of Radixs Astragali, 10 ~ 30 parts of Ramulus et folium taxi cuspidatae, 15 ~ 40 parts of Radix Codonopsis, 60 ~ 90 parts of Rhizoma Atractylodis Macrocephalaes, 60 ~ 90 parts of Herba Scutellariae Barbataes, 60 ~ 90 parts of Herba Hedyotidis Diffusaes, 15 ~ 40 parts of Radix Notoginseng, 60 ~ 90 parts of Fructus Citri Sarcodactylis, 15 ~ 40 parts of Rhizoma Pinelliaes, 60 ~ 90 parts of Semen Coiciss, 15 ~ 40 parts of Radix Bupleuri, 15 ~ 40 parts of Bulbus Fritillariae Cirrhosaes and 60 ~ 90 parts of Poria by ratio of quality and the number of copies.
2. stilbene China fir capsule according to claim 1, is characterized in that being made up of 115 ~ 135 parts of Radixs Astragali, 12 ~ 28 parts of Ramulus et folium taxi cuspidatae, 17 ~ 38 parts of Radix Codonopsis, 63 ~ 88 parts of Rhizoma Atractylodis Macrocephalaes, 63 ~ 88 parts of Herba Scutellariae Barbataes, 63 ~ 88 parts of Herba Hedyotidis Diffusaes, 17 ~ 38 parts of Radix Notoginseng, 63 ~ 88 parts of Fructus Citri Sarcodactylis, 17 ~ 35 parts of Rhizoma Pinelliaes, 63 ~ 88 parts of Semen Coiciss, 17 ~ 38 parts of Radix Bupleuri, 17 ~ 38 parts of Bulbus Fritillariae Cirrhosaes and 63 ~ 88 parts of Poria by ratio of quality and the number of copies.
3. stilbene China fir capsule according to claim 1, is characterized in that being made up of 120 ~ 135 parts of Radixs Astragali, 15 ~ 25 parts of Ramulus et folium taxi cuspidatae, 20 ~ 35 parts of Radix Codonopsis, 70 ~ 85 parts of Rhizoma Atractylodis Macrocephalaes, 70 ~ 85 parts of Herba Scutellariae Barbataes, 70 ~ 85 parts of Herba Hedyotidis Diffusaes, 20 ~ 35 parts of Radix Notoginseng, 70 ~ 85 parts of Fructus Citri Sarcodactylis, 20 ~ 35 parts of Rhizoma Pinelliaes, 70 ~ 85 parts of Semen Coiciss, 20 ~ 35 parts of Radix Bupleuri, 20 ~ 35 parts of Bulbus Fritillariae Cirrhosaes and 70 ~ 85 parts of Poria by ratio of quality and the number of copies.
4. stilbene China fir capsule according to claim 1, is characterized in that being made up of 130 parts of Radixs Astragali, 20 parts of Ramulus et folium taxi cuspidatae, 26 parts of Radix Codonopsis, 78 parts of Rhizoma Atractylodis Macrocephalaes, 78 parts of Herba Scutellariae Barbataes, 78 parts of Herba Hedyotidis Diffusaes, 26 parts of Radix Notoginseng, 78 parts of Fructus Citri Sarcodactylis, 26 parts of Rhizoma Pinelliaes, 78 parts of Semen Coiciss, 26 parts of Radix Bupleuri, 26 parts of Bulbus Fritillariae Cirrhosaes and 78 parts of Poria by ratio of quality and the number of copies.
5. prepare the preparation technology of stilbene China fir capsule according to claim 1, it is characterized in that the preparation technology of stilbene China fir capsule is as follows:
Step one: take 110 ~ 140 parts of Radixs Astragali, 10 ~ 30 portions of Ramulus et folium taxi cuspidatae, 15 ~ 40 parts of Radix Codonopsis, 60 ~ 90 parts of Rhizoma Atractylodis Macrocephalaes, 60 ~ 90 portions of Herba Scutellariae Barbataes, 60 ~ 90 parts of Herba Hedyotidis Diffusaes, 15 ~ 40 portions of Radix Notoginseng, 60 ~ 90 portions of Fructus Citri Sarcodactylis, 15 ~ 40 parts of Rhizoma Pinelliaes, 60 ~ 90 parts of Semen Coiciss, 15 ~ 40 parts of Radix Bupleuri, 15 ~ 40 parts of Bulbus Fritillariae Cirrhosaes and 60 ~ 90 parts of Poria respectively by ratio of quality and the number of copies, then Radix Notoginseng, Bulbus Fritillariae Cirrhosae powder are broken into fine powder, cross 80 mesh sieves;
Step 2: all the other medical materials are added 10 times amount water boiling and extraction 2 times, 2 hours first times, second time 1.5 hours, filters respectively, merges extracted twice liquid;
Step 3: extracting solution heating step 2 obtained is concentrated into the clear paste that relative density is 1.15 ~ 1.25, and heat surveys 80 DEG C; Then, be ground into fine powder after drying under reduced pressure, cross 80 mesh sieves, mix obtained mixture A with fine powder in step one; Again mixture A is granulated, encapsulated, to obtain final product.
6. the preparation technology of stilbene China fir capsule according to claim 5, it is characterized in that mixture A in step 3 being crossed 8 mesh sieves granulates, Co60 radiation sterilization, incapsulates.
7. the preparation technology of stilbene China fir capsule according to claim 6, is characterized in that every capsules 0.4g/ grain.
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| CN103611003A (en) * | 2013-11-22 | 2014-03-05 | 杨兆辉 | Traditional Chinese medicine composition for improving somatic functions of patients with lung cancer and preparation method thereof |
| CN104306807A (en) * | 2014-11-18 | 2015-01-28 | 广东省中医院 | Compound preparation for treating advanced lung cancer and preparing method thereof |
| CN105535691B (en) * | 2016-02-03 | 2018-06-12 | 陈亮 | Microemulsions composition with effect of anti-lung cancer and preparation method thereof |
| CN107375694A (en) * | 2017-08-17 | 2017-11-24 | 哈尔滨市固元科技发展有限公司 | A kind of Chinese medicine composition for preventing and treating Sjogren syndrome and preparation method thereof |
| CN110960664A (en) * | 2019-12-26 | 2020-04-07 | 陈文才 | Traditional Chinese medicine composition for treating cancer and preparation method and application thereof |
| CN111000037A (en) * | 2020-02-20 | 2020-04-14 | 暮羊羊生物科技有限公司 | High-selenium auxiliary anti-cancer goat milk and production method thereof |
| CN113398215A (en) * | 2021-08-06 | 2021-09-17 | 潘震东 | Chinese medicinal composition for treating lung and colon tumor precancerous lesion and preparation method thereof |
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