CN103314981B - A kind of rodent control bait for male endocrine disrupting sterility - Google Patents
A kind of rodent control bait for male endocrine disrupting sterility Download PDFInfo
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- 241000283984 Rodentia Species 0.000 title claims abstract description 11
- 231100000507 endocrine disrupting Toxicity 0.000 title claims abstract 7
- 230000036512 infertility Effects 0.000 title claims abstract 3
- KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 claims abstract description 35
- 229960004596 cabergoline Drugs 0.000 claims abstract description 35
- 239000004480 active ingredient Substances 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims abstract description 3
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- 238000002360 preparation method Methods 0.000 claims description 6
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- 229930006000 Sucrose Natural products 0.000 claims description 5
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- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 5
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 5
- 235000005822 corn Nutrition 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 5
- 235000021307 Triticum Nutrition 0.000 claims description 3
- 241000209140 Triticum Species 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
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- 244000105624 Arachis hypogaea Species 0.000 claims description 2
- 235000010777 Arachis hypogaea Nutrition 0.000 claims description 2
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 1
- 229940081974 saccharin Drugs 0.000 claims 1
- 235000019204 saccharin Nutrition 0.000 claims 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 13
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 26
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- 230000028327 secretion Effects 0.000 description 22
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 18
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- PXZAWHSJYIECNQ-UHFFFAOYSA-N apholate Chemical compound C1CN1P1(N2CC2)=NP(N2CC2)(N2CC2)=NP(N2CC2)(N2CC2)=N1 PXZAWHSJYIECNQ-UHFFFAOYSA-N 0.000 description 4
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Abstract
本发明公开了一种雄性内分泌干扰不育的灭鼠饵料。它包括作为唯一活性成份的卡麦角林和可接受的辅料，所述的卡麦角林占雄性内分泌干扰不育的灭鼠饵料总质量的0.0001～0.01%。本发明通过将适量的卡麦角林混合在合适的食饵中，得到的饵料对害鼠适口性好，控制效果持久，安全低污染，且生产工艺简单，成本较低，适合大规模推行用于控制害鼠种群数量，将其危害长期压制于经济阈值之下。The invention discloses a rodent control bait for male endocrine disrupting sterility. It includes cabergoline as the only active ingredient and acceptable auxiliary materials, and the cabergoline accounts for 0.0001-0.01% of the total mass of the male endocrine disrupting sterile rodent control bait. In the present invention, by mixing an appropriate amount of cabergoline into suitable bait, the obtained bait has good palatability to pest rodents, long-lasting control effect, safety and low pollution, simple production process and low cost, and is suitable for large-scale implementation for control The number of pest populations suppresses its harm below the economic threshold for a long time.
Description
Technical field:
The invention belongs to muroid control drug world, be specifically related to a kind of male internal secretion and disturb sterile rat controlling bait.
Background technology:
The plague of rats is one of the main disasters kind in current global biological epidemics (Prakash1988; Singleton et al.1999; Jacob2013),, when causing huge economic loss, human body health in serious threat.According to the World Food Programme's statistics, grain is lost more than 3,300 ten thousand-5,000 ten thousand tons because of the plague of rats every year in the whole world, and enough 1.3 hundred million-1.9 hundred million people eat 1 year, and in Asia and Africa, the grain of being eaten steathily by muroid accounts for the 15%(Stenseth et al.2003 of gross yield).The loss that the annual vermin in Europe is caused exceedes 1,000,000,000 Euros, and because the inefficacy loss of control measure increases (Jacob2013) year by year.China is one of the most serious country of the global plague of rats, Tenth Five-Year Plan Period the whole nation account for 1/4 of national arable area because the disaster-stricken farmland area of the plague of rats reaches 2,500 ten thousand hectares, nearly 20,000,000,000 jin of grain of loss (Shi great Zhao etc. 2011) every year.In addition, along with the change of agricultural planting structure, a large amount of plantations of high value crop, the loss that also makes muroid cause is more serious.China's grassland plague of rats is also very serious, annual more than 700,000,000 mu of the area that occur, become the key factor that causes grass-land deterioration, desertification, water and soil loss, and China's sustainable development of animal husbandry, Rangeland Biodiversity protection, ecology of grassland construction and people's health (Shi great Zhao etc. 2000 in serious threat; Zhang Zhibin 2003).Bandicoot not only endangers agriculture forest and husbandry, also the industries such as food, traffic, communication and building is brought to very large harm, such as pilferage and contaminated food products, burrow destroy roadbed and building, communication and electric power cable etc. bite.In addition, muroid can be carried more than 200 and be planted pathogene, can propagate multiple zoonosis, and what wherein can make that people causes a disease has 57 kinds, to mankind's harmfulness very large have the plague, Hemorrhagic fever, a leptospirosis etc.Even in China's Tenth Five-Year Plan Period in modern age, the number of the infected of mouse communicable disease adds up to more than 20 ten thousand people (Zhou Kai He Hehong pavilion 2009).Therefore, plague of rats problem will affect China's sustainable economic development and people's lives Ankang within a very long time from now on.
Up to now, the main method of the anti-plague of rats processed is still to rely on chemical deratization medicine, but along with the long-term use of rodent poison bait, the effect that raticide kills mouse day by day tends to become weak, show as the difficulty that kills mouse, the effect of the going out phenomenons (Huang little Li etc. 2010,2013) such as even bounce-back of holding time that short, poison bait consumption increases and mouse density does not decline.And some chemical deratization chemicals contamination environment, even endanger the natural enemy of bandicoot and other non-target biologies.The beginning of the fifties in last century anticoagulation class rodent poison bait appearance, indicate the major progress of rodent poison bait, but along with using the increase of this type of medicine time, drug-fast problem but day by day shows especially.In Guangdong Province, multiple areas have not only occurred that pesticide resistance individuality and drug susceptibility reduce trend, have formed certain pesticide resistance bandicoot population (Zhang Shiyan etc. 2002 even; Ou Hanbiao etc. 2004; Yi Jianrong etc. 2004,2005; Liang Lian etc. 2005; Chen Huohua etc. 2007; Dai Guangxiang etc. 2007; Feng Zhi is brave waits 2007; Wang et al.2008).The predicament of these " rodent-damage-frees directly has influence on raticide manufacturing enterprise and " rodent-damage-free service industry, causes manufacturing enterprise's production capacity idle in a large number, and service industry's customer complaint increase and satisfaction decline.
The strategy of the aspect of bandicoot control is in recent years mainly sterile control, make male or female bandicoot sterilization by certain technology and method, or hinder that its embryo nidation is grown and the growing of the young, reduce the fertility-rate of bandicoot with this, control its population quantity and density, it is exactly in fact fertility-rate control.Theoretically, apholate is more safer than traditional chemical rodenticide, pollute little even pollution-free, its maximum advantage be control action lasting and in the time of low-density more remarkable effect.
But early stage apholate is poor because of its palatability, and slowly, industrial production technology is immature in effect, and cost is high and be difficult to be accepted by people.In recent years along with the maieutic research of beast, and for the mankind and the hormone of domestic animal genital regulating and the production technology of chaff interference, thereby some are filtered out and have been applicable to the acarpous medicine of vermin control.Due to muroid have adaptable, Mating Systems is complicated, breed the features such as rapid, therefore best apholate should be able to make male and female all sterile, and can or alleviate inhibition in multiple breeding stage, and can make sterile effect have certain lasting effect.
Cabergoline (Cabergoline) is a kind of dopamine-receptor stimulant, medically be mainly used in Parkinson's and the treatment of hyperprolactinemia in early stage or late period, this medicine and d2 dopamine receptor have high compatibility, can compete the effect that suppresses prolactin, thereby suppress carrying out and point puerperium galactopoiesis of gestation, can make pregnancy termination and miscarriage and point puerperium can not lactation (Rains et al.1995).In zoopery, find female cats, dog and red fox etc. to have the effect of terminal pregnancy and inhibition lactation, and in experimental rat and mouse, also had similar effect, but had (the Negishi et al.1997 of sensitivity differences between obvious kind; Marks et al.2001).Inhibitory action and the effect of Cabergoline to buck breeding, there is no report so far.
Have not yet to see report and the patent of the male bandicoot apholate of conduct of " Cabergoline+bait ".
Summary of the invention:
The object of this invention is to provide one to bandicoot good palatability, can suppress efficiently the male internal secretion of the fertility of male bandicoot and disturb sterile rat controlling bait.
The present invention is by appropriate Cabergoline is blended in suitable bait, and the bait obtaining, to bandicoot good palatability, can suppress the fertility of male bandicoot efficiently, thereby has realized object of the present invention.
Sterile rat controlling bait is disturbed in male internal secretion of the present invention, it is characterized in that, comprise Cabergoline and acceptable auxiliary material as unique active ingredient, described Cabergoline accounts for male internal secretion and disturbs 0.0001～0.01% of sterile rat controlling bait gross mass.
Preferably, described male internal secretion disturbs sterile rat controlling bait by gross mass mark 100%, is made up of following composition: Cabergoline 0.0001%～0.01%, edible oil 0.5～1%, sugar and/or milk powder, or, asccharin and/or cream 0.1%-1%, surplus is foodstuff.
In weather damp-heat area, male internal secretion of the present invention disturbs sterile rat controlling bait preferably to use asccharin and/or cream, to avoid sugar and milk powder ferment in bait or assemble insect.
Described foodstuff is preferably the one in paddy, rice, wheat, corn, soya bean or peanut.
Described edible oil is preferably edible vegetable oil.
Described sugar is preferably white sugar or rock sugar.
Male internal secretion of the present invention disturbs the preparation method of sterile rat controlling bait to be: first Cabergoline is dissolved in ether or ethanol, again by sugar and/or milk powder, or, asccharin and/or cream, after mixing with edible oil, be dissolved in warm water, add again and be dissolved with the ether of Cabergoline or ethanolic solution to above-mentioned warm water, then this warm water is mixed with foodstuff, stir, being placed in container with lid soaks 12～24 hours, stir completely during this time 3～4 times, after normal temperature dries in the shade, ether or ethanol can all vapor away, thereby obtain male internal secretion and disturb sterile rat controlling bait.As long as therefore the amount of ether or ethanol can be dissolved Cabergoline completely.
Cabergoline is that liposoluble substance is water-soluble hardly, the present invention is first dissolved in Cabergoline in ether or ethanol completely, this being dissolved with to the ether of Cabergoline or ethanolic solution joins and contains sugar and/or milk powder again, or, asccharin and/or cream, in the warm water of edible oil, Cabergoline is dissolved in edible oil, and then mix with foodstuff, stir, soaking 12～24 hours is in order to allow Cabergoline can infiltrate foodstuff inside, and foodstuff is moist in the situation that, relatively have adsorptivity, the edible oil that contains Cabergoline also can be attached to foodstuff surface.Edible oil not only has the effect of dissolving Cabergoline, is conducive to mixing of Cabergoline and foodstuff, can also improve the palatability of bait.
The using method of sterile rat controlling bait is disturbed in male internal secretion of the present invention, to use or in bandicoot quantity higher period first, intensive dispensing, each release position is thrown in 50～200g depending on mouse density height, bandicoot as much as possible is taken medicine sterile, reuses or during for lower period of bandicoot quantity, can reduce dispensing point and dosage, each input 20～100g, but for to obtain best effect, the interval reusing should not exceed 30 days period; After this can extend the dosing interval time and reduce dosage according to bait consumption.
The present invention is by being blended in appropriate Cabergoline in suitable bait, the bait obtaining is to bandicoot good palatability, control effect is lasting, the low pollution of safety, and production technology is simple, cost is lower, is applicable to extensive carrying out and is used for controlling bandicoot population quantity, is endangered and suppresses for a long time under economic threshold.
Embodiment:
Following examples are to further illustrate of the present invention, are not limitations of the present invention.
Embodiment 1:
It is preparation like this that sterile rat controlling bait is disturbed in the male internal secretion of every 1000g: weigh 984.999g paddy and be put in container, weigh again 1mg Cabergoline, be dissolved in the ether of 10ml, after again 5g edible rapeseed oil being mixed with 10g white sugar, be dissolved in 100ml warm water, the ether that is dissolved with Cabergoline is joined in above-mentioned warm water, stir, again this warm water and paddy are mixed, being placed in container with lid sealing soaks 12 hours, stir completely during this time 4 times, normal temperature dries in the shade, in this process, ether vapors away completely, sterile rat controlling bait is disturbed in the male internal secretion that obtains the present embodiment.
Above-mentioned male internal secretion is disturbed to a large amount of saturated inputs of fixing a point of sterile rat controlling bait: in muroid breeding period, select two sealing fences that mouse density is identical, in a fence, throw in therein bait 5 places, the each 200g in every place, remain the saturated input of bait, another not bait throwing in of fence in contrast.Record month by month mouse number change and the sterile situation of male mouse, result shows: the newly-increased quantity of mouse of testing fence after 3 months has declined 70% than contrast, and male mouse sperm quality decline 58%, and female mouse pregnancy rate is lower, and experimental group only has a small amount of young output.
Embodiment 2:
It is preparation like this that sterile rat controlling bait is disturbed in the male internal secretion of every 1000g: weigh 988.995g corn and be put in container, weigh again 5mg Cabergoline, be dissolved in the ethanol of 15ml, after again 10g edible corn oil being mixed with 1g milk powder, be dissolved in 100ml warm water, the ethanol that is dissolved with Cabergoline is joined in above-mentioned warm water, stir, again this warm water and corn are mixed, being placed in container with lid sealing soaks 24 hours, stir completely during this time 3 times, after normal temperature dries in the shade, in this process, ethanol vapors away completely, sterile rat controlling bait is disturbed in the male internal secretion that obtains the present embodiment.
Disturb sterile rat controlling bait to fix a point to throw in above-mentioned male internal secretion: in muroid breeding period in batches, select two sealing fences that mouse density is identical, in a fence, throw in therein bait 5 places, the each 100g in every place, once, another not bait throwing in of fence is in contrast for tonic weekly, record month by month mouse number change, result shows: the mouse population quantity of testing fence after 3 months is 81% than contrast fence rate of descent, and male body spermatozoa motility reduces more than 70%, without female body pregnancy or the output young.
Embodiment 3:
It is preparation like this that sterile rat controlling bait is disturbed in the male internal secretion of every 1000g: weigh 985.99g wheat and be put in container, weigh again 10mg Cabergoline, be dissolved in the ethanol of 20ml, again by 10g edible peanut oil and 1g asccharin, after 3g cream mixes, be dissolved in 100ml warm water, the ethanol that is dissolved with Cabergoline is joined in above-mentioned warm water, stir, again this warm water and corn are mixed, being placed in container with lid sealing soaks 24 hours, stir completely during this time 3 times, normal temperature dries in the shade, in this process, ethanol vapors away completely, sterile rat controlling bait is disturbed in the male internal secretion that obtains the present embodiment.
Above-mentioned male internal secretion is disturbed to the disposable a large amount of input of fixing a point of sterile rat controlling bait: in muroid breeding period, select two sealing fences that mouse density is identical, in a fence, throw in therein bait 3 places, every 200g of place, another not bait throwing in of fence in contrast, the number change of 3 months " Invest, Then Investigate " bandicoots, result shows: experiment fence with contrast fence and compare, mouse population quantity rate of descent is 90%, and male mouse sperm quality significantly declines 87%, almost individual without new life in population.
Embodiment 4:
It is preparation like this that sterile rat controlling bait is disturbed in the male internal secretion of every 1000g: weigh 985.90g paddy and be put in container, weigh again 100mg Cabergoline, be dissolved in the ethanol of 20ml, again by 10g edible peanut oil and 1g white sugar, after 3g milk powder mixes, be dissolved in 100ml warm water, the ethanol that is dissolved with Cabergoline is joined in above-mentioned warm water, stir, again this warm water and paddy are mixed, being placed in container with lid sealing soaks 24 hours, stir completely during this time 3 times, normal temperature dries in the shade, in this process, ethanol vapors away completely, sterile rat controlling bait is disturbed in the male internal secretion that obtains the present embodiment.
Above-mentioned male internal secretion is disturbed to the disposable a large amount of input of fixing a point of sterile rat controlling bait: in muroid breeding period, select two sealing fences that mouse density is identical, in a fence, throw in therein bait 5 places, every 50g of place, another not bait throwing in of fence in contrast, the number change of 3 months " Invest, Then Investigate " bandicoots, result shows: experiment fence with contrast fence and compare, mouse population quantity rate of descent is 92%, and male mouse sperm quality significantly declines 90%, does not find newborn individual in population.
Claims (5)
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| CN201310292247.0A CN103314981B (en) | 2013-07-11 | 2013-07-11 | A kind of rodent control bait for male endocrine disrupting sterility |
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| CN201310292247.0A CN103314981B (en) | 2013-07-11 | 2013-07-11 | A kind of rodent control bait for male endocrine disrupting sterility |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0470325A1 (en) * | 1990-08-06 | 1992-02-12 | Maria Francesca Devoto | Composition and method to keep under control the reproduction rate of vertebrate animals by means of a composition containing peripheral dopamine agonists |
| CN101664039A (en) * | 2008-09-03 | 2010-03-10 | 广东省昆虫研究所 | Female chemically sterilizing rat bait |
| CN103125530A (en) * | 2013-03-26 | 2013-06-05 | 西安文理学院 | Anti-breeding rodenticide |
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2013
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0470325A1 (en) * | 1990-08-06 | 1992-02-12 | Maria Francesca Devoto | Composition and method to keep under control the reproduction rate of vertebrate animals by means of a composition containing peripheral dopamine agonists |
| CN101664039A (en) * | 2008-09-03 | 2010-03-10 | 广东省昆虫研究所 | Female chemically sterilizing rat bait |
| CN103125530A (en) * | 2013-03-26 | 2013-06-05 | 西安文理学院 | Anti-breeding rodenticide |
Non-Patent Citations (2)
| Title |
|---|
| 鼠的化学不育剂与遗传防制展望;Rex E.March and Walter E.Hawar;《中国鼠类防防制杂志》;19860620;第2卷(第3期);第187-192页 * |
| 鼠类化学不育剂的发展;高源;《中国媒介生物学及控制杂志》;19961220;第7卷(第6期);第481-485页 * |
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