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CN1032856C - 咪唑－5－羧酸衍生物的新的缩醛酯的制备方法 - Google Patents

咪唑－5－羧酸衍生物的新的缩醛酯的制备方法 Download PDF

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Publication number
CN1032856C
CN1032856C CN92112003A CN92112003A CN1032856C CN 1032856 C CN1032856 C CN 1032856C CN 92112003 A CN92112003 A CN 92112003A CN 92112003 A CN92112003 A CN 92112003A CN 1032856 C CN1032856 C CN 1032856C
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CN
China
Prior art keywords
formula
compound
carboxylic acid
preparation
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN92112003A
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English (en)
Chinese (zh)
Other versions
CN1071426A (zh
Inventor
D·宾德
J·温伯格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemisch Pharmazeutische Forschungs GmbH
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Chemisch Pharmazeutische Forschungs GmbH
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Filing date
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Application filed by Chemisch Pharmazeutische Forschungs GmbH filed Critical Chemisch Pharmazeutische Forschungs GmbH
Publication of CN1071426A publication Critical patent/CN1071426A/zh
Application granted granted Critical
Publication of CN1032856C publication Critical patent/CN1032856C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN92112003A 1991-10-04 1992-09-30 咪唑－5－羧酸衍生物的新的缩醛酯的制备方法 Expired - Fee Related CN1032856C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0198791A AT398202B (de) 1991-10-04 1991-10-04 Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
ATA1987/91 1991-10-04

Publications (2)

Publication Number Publication Date
CN1071426A CN1071426A (zh) 1993-04-28
CN1032856C true CN1032856C (zh) 1996-09-25

Family

ID=3525398

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92112003A Expired - Fee Related CN1032856C (zh) 1991-10-04 1992-09-30 咪唑－5－羧酸衍生物的新的缩醛酯的制备方法

Country Status (22)

Country Link
US (1) US5298519A (fi)
EP (1) EP0535420A1 (fi)
JP (1) JP2544565B2 (fi)
CN (1) CN1032856C (fi)
AT (1) AT398202B (fi)
AU (1) AU649357B2 (fi)
CA (1) CA2079735A1 (fi)
CZ (1) CZ301992A3 (fi)
FI (1) FI924353A (fi)
HR (1) HRP920817A2 (fi)
HU (1) HUT62291A (fi)
IL (1) IL103329A (fi)
LV (1) LV10256B (fi)
MY (1) MY108350A (fi)
NO (1) NO923798L (fi)
NZ (1) NZ244320A (fi)
RU (1) RU2105764C1 (fi)
SI (1) SI9200240A (fi)
SK (1) SK301992A3 (fi)
TW (1) TW223073B (fi)
YU (1) YU48290B (fi)
ZA (1) ZA927205B (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2105939B1 (es) * 1994-08-02 1998-07-01 Uriach & Cia Sa J Nuevos pirazoles con actividad antagonista de la angiotensina ii.
CN101024643A (zh) * 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
WO2008067687A1 (fr) * 2006-12-06 2008-06-12 Shanghai Allist Pharmaceutical., Inc. Sels de dérivés d'acide imidazol-5-carboxylique, procédés de préparation et utilisation
CN101195615B (zh) * 2006-12-06 2013-03-27 深圳市信立泰资产管理有限公司 咪唑-5-羧酸衍生物的盐、制备方法及其药物组合物
CN101214242A (zh) * 2007-01-05 2008-07-09 上海艾力斯医药科技有限公司 新的药用组合物
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
CN101317842A (zh) 2007-06-07 2008-12-10 上海艾力斯医药科技有限公司 一种咪唑-5-羧酸衍生物的治疗用途
CN101367795B (zh) * 2007-08-17 2012-05-02 上海艾力斯生物医药有限公司 一种咪唑-5-羧酸衍生物及其制备方法
CN101407511B (zh) * 2007-10-11 2013-01-09 上海艾力斯生物医药有限公司 一种结晶型的咪唑-5-羧酸衍生物
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103012377A (zh) * 2011-09-27 2013-04-03 江苏艾力斯生物医药有限公司 一种咪唑-5-羧酸酯的重结晶方法
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
EP0479892A1 (en) * 1989-06-30 1992-04-15 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
ATE113281T1 (de) * 1989-08-02 1994-11-15 Takeda Chemical Industries Ltd Pyrazol-derivate, verfahren zu deren herstellung und anwendung.
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
DE69329982T2 (de) * 1992-06-02 2001-09-27 Sankyo Co., Ltd. 4-Carboxyimidazolderivate als Angiotensin-II-Antagonisten und ihre therapeutische Verwendung

Also Published As

Publication number Publication date
RU2105764C1 (ru) 1998-02-27
AT398202B (de) 1994-10-25
FI924353A0 (fi) 1992-09-29
SI9200240A (en) 1993-06-30
AU2617692A (en) 1993-04-08
AU649357B2 (en) 1994-05-19
JPH05310731A (ja) 1993-11-22
CZ301992A3 (en) 1993-08-11
YU48290B (sh) 1998-05-15
ZA927205B (en) 1993-03-23
IL103329A (en) 1996-10-31
EP0535420A1 (de) 1993-04-07
CA2079735A1 (en) 1993-04-05
SK301992A3 (en) 1995-10-11
FI924353A (fi) 1993-04-05
YU87592A (sh) 1995-10-03
JP2544565B2 (ja) 1996-10-16
NZ244320A (en) 1995-01-27
HRP920817A2 (en) 1996-08-31
ATA198791A (de) 1994-02-15
LV10256A (lv) 1994-10-20
TW223073B (fi) 1994-05-01
NO923798L (no) 1993-04-05
IL103329A0 (en) 1993-03-15
HUT62291A (en) 1993-04-28
NO923798D0 (no) 1992-09-30
CN1071426A (zh) 1993-04-28
LV10256B (en) 1995-04-20
US5298519A (en) 1994-03-29
HU9203149D0 (en) 1992-12-28
MY108350A (en) 1996-09-30

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