CN103215178B - Adsorption and fixation device for cells or tiny particles designed and manufactured using hollow-core optical fibers - Google Patents
Adsorption and fixation device for cells or tiny particles designed and manufactured using hollow-core optical fibers Download PDFInfo
- Publication number
- CN103215178B CN103215178B CN201310093105.1A CN201310093105A CN103215178B CN 103215178 B CN103215178 B CN 103215178B CN 201310093105 A CN201310093105 A CN 201310093105A CN 103215178 B CN103215178 B CN 103215178B
- Authority
- CN
- China
- Prior art keywords
- hollow
- optical fiber
- core optical
- cells
- fixation device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
技术领域 technical field
本发明涉及一种应用空芯光纤设计制作的细胞或微小颗粒的吸附固定装置。 The present invention relates to an adsorption and fixation device for cells or tiny particles designed and manufactured using hollow-core optical fibers.
背景技术 Background technique
近年来，细胞在生物医学研究和应用时，经常需要吸附固定后，再进行进一步的显微操作。另外，微纳技术的发展、微小颗粒等也都需要进行固定操作。所以需要能够对微小颗粒进行操纵吸附固定的设备日益成为需求热点。目前这方面的设备很少，比较成熟的设备是德国Eppendorf公司生产的设备，但是该设备是使用塑料细管来连接微细管和负压吸附装置，这样容易漏液，另外需要制备微细管尖头，制备需要专用设备等，价格较高。 In recent years, in biomedical research and application, cells often need to be adsorbed and fixed before further micromanipulation. In addition, the development of micro-nano technology and tiny particles also require immobilization operations. Therefore, the need for devices capable of manipulating, adsorbing, and immobilizing tiny particles has increasingly become a hot demand. At present, there are very few equipments in this area. The relatively mature equipment is produced by Eppendorf in Germany. However, this equipment uses plastic thin tubes to connect the microtubes and negative pressure adsorption devices, which is easy to leak liquid. In addition, microtube tips need to be prepared. , preparation requires special equipment, etc., and the price is higher.
本发明基于空芯光纤，空芯光纤兼具微细管和微细管尖端的作用，易于设计制作，由于微细管和微细管尖端的一体化，不会漏液，对配件要求低，可以降低费用。 The invention is based on the hollow-core optical fiber. The hollow-core optical fiber has both the functions of the microtube and the tip of the microtube, and is easy to design and manufacture. Due to the integration of the microtube and the tip of the microtube, there is no leakage, and the requirements for accessories are low, which can reduce the cost.
发明内容 Contents of the invention
本发明的目的在于针对已有技术存在的缺陷，提供一种应用空芯光纤设计制作的细胞或微小颗粒的吸附固定装置，具有简单易制作、对配件要求低，操纵方便等特点。 The object of the present invention is to solve the defects of the prior art, and provide an adsorption and fixation device for cells or tiny particles designed and manufactured using a hollow-core optical fiber, which has the characteristics of simple and easy production, low requirements for accessories, and convenient operation.
本发明采用下述技术方案： The present invention adopts following technical scheme:
一种应用空芯光纤设计制作的细胞或微小颗粒的吸附固定装置，包括空芯光纤和液压或气压负压装置，所述空芯光纤的一端制作成微细吸管的尖端，另一端密封连接液压或气压负压装置。 An adsorption and fixation device for cells or tiny particles designed and manufactured using a hollow-core optical fiber, including a hollow-core optical fiber and a hydraulic or pneumatic negative pressure device. Pneumatic negative pressure device.
所述空芯光纤的一端制作成微细吸管的尖端的过程为：将空芯光纤在光纤对接仪器上进行拉制，然后放电制作出尖端。 The process of making one end of the hollow-core fiber into the tip of the micro-pipette is as follows: drawing the hollow-core fiber on an optical fiber docking instrument, and then producing the tip by electric discharge.
本发明与现有技术相比较，具有如下显而易见的突出实质性特点和显著优点： Compared with the prior art, the present invention has the following obvious outstanding substantive features and significant advantages:
本发明应用空芯光纤设计制作细胞或微小颗粒的吸附固定装置结构简单，易于制作和操纵，具有高灵敏性、高分辨率，价格低廉。 The invention adopts the hollow-core optical fiber to design and manufacture the adsorption and fixation device for cells or tiny particles, which has a simple structure, is easy to manufacture and operate, has high sensitivity, high resolution and low price.
附图说明 Description of drawings
图1是本发明一个实施例采用液压微调的装置示意图。 Fig. 1 is a schematic diagram of a device using hydraulic fine adjustment according to an embodiment of the present invention.
图2是本发明另一个实施例采用注射器的装置示意图。 Fig. 2 is a schematic diagram of a device using a syringe in another embodiment of the present invention.
具体实施方式 Detailed ways
本发明的优选实施例结合附图详述如下： Preferred embodiments of the present invention are described in detail as follows in conjunction with accompanying drawings:
一种应用空芯光纤设计制作的细胞或微小颗粒的吸附固定装置，包括空芯光纤和液压或气压负压装置，所述空芯光纤的一端制作成微细吸管的尖端，另一端密封连接液压或气压负压装置。 An adsorption and fixation device for cells or tiny particles designed and manufactured using a hollow-core optical fiber, including a hollow-core optical fiber and a hydraulic or pneumatic negative pressure device. Pneumatic negative pressure device.
实施例一： Embodiment one:
在显微镜的观察下，通过多维移动平台，使空芯光纤的一端接近细胞或微小颗粒物，微调空芯光纤的另一端的液压微调装置，然后利用连接的液压微旋钮，抽吸空芯光纤中的液体（如油或水），使空芯光纤的一端能够在微小负压作用下吸附住细胞或微小颗粒，可以进行其他操作。 Under the observation of the microscope, through the multi-dimensional mobile platform, one end of the hollow-core fiber is close to cells or tiny particles, and the hydraulic fine-tuning device at the other end of the hollow-core fiber is fine-tuned, and then the connected hydraulic micro-knob is used to suck the particles in the hollow-core fiber Liquid (such as oil or water), so that one end of the hollow-core optical fiber can absorb cells or tiny particles under the action of a small negative pressure, and other operations can be performed.
实施例二： Embodiment two:
在显微镜的观察下，通过多维移动平台，使空芯光纤的一端接近细胞或微小颗粒物，微调空芯光纤的另一端的注射器，然后利用连接的注射器，抽吸空芯光纤中的其他（如空气），使空芯光纤的一端能够在微小负压作用下吸附住细胞或微小颗粒，可以进行其他操作。 Under the observation of the microscope, through the multi-dimensional moving platform, make one end of the hollow-core fiber close to cells or tiny particles, fine-tune the syringe at the other end of the hollow-core fiber, and then use the connected syringe to suck other particles (such as air) in the hollow-core fiber ), so that one end of the hollow-core optical fiber can absorb cells or tiny particles under the action of a small negative pressure, and other operations can be performed.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310093105.1A CN103215178B (en) | 2013-03-22 | 2013-03-22 | Adsorption and fixation device for cells or tiny particles designed and manufactured using hollow-core optical fibers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310093105.1A CN103215178B (en) | 2013-03-22 | 2013-03-22 | Adsorption and fixation device for cells or tiny particles designed and manufactured using hollow-core optical fibers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103215178A CN103215178A (en) | 2013-07-24 |
| CN103215178B true CN103215178B (en) | 2014-10-01 |
Family
ID=48813347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310093105.1A Expired - Fee Related CN103215178B (en) | 2013-03-22 | 2013-03-22 | Adsorption and fixation device for cells or tiny particles designed and manufactured using hollow-core optical fibers |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103215178B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2345961A1 (en) * | 1998-09-30 | 2000-04-27 | Michael J. Renn | Laser-guided manipulation of non-atomic particles |
| US7228053B1 (en) * | 2004-06-21 | 2007-06-05 | Yoram Palti | Transporting matter that is enclosed within a container through a hollow optical fiber |
| CN101880024A (en) * | 2010-05-25 | 2010-11-10 | 中国科学院物理研究所 | Preparation method of novel probe based on gold-silver nanowire optical waveguide |
| CN102185244A (en) * | 2011-04-14 | 2011-09-14 | 福州高意通讯有限公司 | Method for manufacturing end face of high-power optical fiber laser |
| CN102914531A (en) * | 2012-10-22 | 2013-02-06 | 上海大学 | System for detecting internal components and environment of cell by using SERS (Surface Enhanced Raman Scattering) nano optical fiber probe |
-
2013
- 2013-03-22 CN CN201310093105.1A patent/CN103215178B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2345961A1 (en) * | 1998-09-30 | 2000-04-27 | Michael J. Renn | Laser-guided manipulation of non-atomic particles |
| US7228053B1 (en) * | 2004-06-21 | 2007-06-05 | Yoram Palti | Transporting matter that is enclosed within a container through a hollow optical fiber |
| CN101880024A (en) * | 2010-05-25 | 2010-11-10 | 中国科学院物理研究所 | Preparation method of novel probe based on gold-silver nanowire optical waveguide |
| CN102185244A (en) * | 2011-04-14 | 2011-09-14 | 福州高意通讯有限公司 | Method for manufacturing end face of high-power optical fiber laser |
| CN102914531A (en) * | 2012-10-22 | 2013-02-06 | 上海大学 | System for detecting internal components and environment of cell by using SERS (Surface Enhanced Raman Scattering) nano optical fiber probe |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103215178A (en) | 2013-07-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN204564168U (en) | A kind of pipette | |
| CN103215178B (en) | Adsorption and fixation device for cells or tiny particles designed and manufactured using hollow-core optical fibers | |
| CN103800050A (en) | Vacuum aspiration curet | |
| CN106861901A (en) | The filtration system of magnetic impurity in magnetic impurity filter unit, coal liquefaction oil product | |
| CN203620898U (en) | Glue storage tank of vacuum glue potting machine | |
| CN205814311U (en) | A kind of pull-type pressure transducer flusher | |
| CN204807515U (en) | Test standing wave tube for porous material acoustic absorption performance | |
| CN202554121U (en) | Deep surgery reflective mirror | |
| CN203178022U (en) | A direct measuring apparatus of the unstable-state force of the interaction between a shock wave and a model sphere | |
| CN202289184U (en) | Automatic pressure regulating device for central negative pressure aspirator | |
| CN202290068U (en) | Negative pressure system of experimental cabin | |
| CN103159403A (en) | Method for designing and manufacturing minuteness suction tubes by hollow-center optical fibers | |
| CN206718136U (en) | A kind of convenient water absorber for Clay article making | |
| CN203503966U (en) | Integrated type folding carbon dioxide laser pipe | |
| CN204841733U (en) | A novel test tube instrument for medicine inspection | |
| CN102730670A (en) | Preparation method of non-planar graphical graphene | |
| CN202688532U (en) | Electrospinning device | |
| CN203630106U (en) | Alkali burette | |
| CN204278392U (en) | Multi-cavity tubing precise injection mould throw-out collar | |
| CN203147138U (en) | Capillary connector | |
| CN202925002U (en) | Unicellular microsurgical needle for protozoa | |
| CN202648660U (en) | Outdoor level determinator | |
| CN203809259U (en) | Novel electric diaphragm pump | |
| CN207398370U (en) | A kind of Three Degree Of Freedom detent mechanism | |
| CN202315839U (en) | Vacuum pressure induction experiment device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141001 Termination date: 20200322 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |