CN103211957A - Alcohol relieving and liver protecting composition and application thereof - Google Patents
Alcohol relieving and liver protecting composition and application thereof Download PDFInfo
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- CN103211957A CN103211957A CN2013101570722A CN201310157072A CN103211957A CN 103211957 A CN103211957 A CN 103211957A CN 2013101570722 A CN2013101570722 A CN 2013101570722A CN 201310157072 A CN201310157072 A CN 201310157072A CN 103211957 A CN103211957 A CN 103211957A
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- Prior art keywords
- liver
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- bulbus allii
- application
- protecting
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Links
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 210000004185 liver Anatomy 0.000 title claims abstract description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 26
- 230000002633 protecting effect Effects 0.000 title claims abstract description 24
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 claims abstract description 16
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 14
- 231100000753 hepatic injury Toxicity 0.000 claims abstract description 12
- 208000007848 Alcoholism Diseases 0.000 claims description 27
- 201000007930 alcohol dependence Diseases 0.000 claims description 27
- 239000002775 capsule Substances 0.000 claims description 7
- 238000002481 ethanol extraction Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 23
- 239000002994 raw material Substances 0.000 abstract description 5
- 240000002234 Allium sativum Species 0.000 abstract description 4
- 235000004611 garlic Nutrition 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 2
- 206010067125 Liver injury Diseases 0.000 abstract 1
- 239000000469 ethanolic extract Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- 238000000605 extraction Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 230000037396 body weight Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 241001529936 Murinae Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000005228 liver tissue Anatomy 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000234282 Allium Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000222336 Ganoderma Species 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 244000046146 Pueraria lobata Species 0.000 description 1
- 235000010575 Pueraria lobata Nutrition 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002075 anti-alcohol Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000003673 groundwater Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- HBYYJIPCYANMBX-BAOOBMCLSA-M sodium;[(3s,4r,5r)-3,4,5-trihydroxy-2-oxo-6-phosphonooxyhexyl] hydrogen phosphate Chemical compound [Na+].OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)COP(O)([O-])=O HBYYJIPCYANMBX-BAOOBMCLSA-M 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an alcohol relieving and liver protecting composition which comprises the components in percentage by weight as follows: 20-45% of puerarin and 55-80% of garlic, wherein the garlic is preferably a garlic ethanol extract. The invention further discloses application of the composition in preparing medicines for treating and preventing liver injury. The composition disclosed by the invention is easy in obtaining of the raw materials and low in cost, has remarkable alcohol relieving and liver protecting effect, and is less in side effect and safe and stable in efficacy.
Description
Technical field
The present invention relates to a kind of compositions that is used for relieving alcoholism and protecting the liver.
Background technology
In China, Chinese liquor has become a kind of culture, along with the development of the raising of people's living standard and society, though friend's party, commercial affairs are entertained still public affair receive, all can not keep from drink.But too much drinks, and can cause great threat to healthy, of great impact no matter be to stomach or liver or other organs, because the gastrorrhagia that insobriety causes, alcoholic liver etc. are more and more.
Radix Puerariae (Radix Puerariae) is a legume pueraria lobata, is a kind of plant of common medicine-food two-purpose.Modern pharmacology studies show that, Radix Puerariae has the hepatocellular regeneration capacity of raising, recover the normal liver function, promote bile secretion, prevent fat in the liver accumulation, and can enhance metabolism, strengthen liver detoxification function, prevent the effect of ethanol to the damage of liver, flavones ingredient puerarin (puerarin) has wherein played main effect especially, so people are applied to the medicine or the health product of relieving alcoholism and protecting the liver.But still there are variety of issue in the antialcoholic medicine or the health product of report at present.
Such as, publication No. is the Chinese patent application of 102106876A, discloses a kind of antialcoholism capsule that contains Fructose Diphosphate sodium, puerarin and Ganoderma spore powder with cellular wall broken, there is the not good enough problem of cost of material height, complicated process of preparation and effect in this antialcoholism capsule.Be the Chinese patent application of CN101874857A such as publication No. again, disclose a kind of liver-protecting white spirit that contains Radix Puerariae, Fructus Lycii, Fructus Crataegi and Fructus Chaenomelis, this liver-protecting white spirit exists raw material more than complexity and the not good enough problem of effect.In addition, also have a lot of reports that adopt Radix Puerariaes or puerarin to carry out the compositions of compatibility, they also often exist raw material more, be difficult for acquisition, complex manufacturing technology, cost is higher, effect is not good enough problem.Because all medicines are the same with ethanol, generally all need to carry out metabolism through liver, if composition is too complicated, can increase the burden of liver on the contrary, make the effect of relieving alcoholism and protecting the liver have a greatly reduced quality, and the pharmacology of a lot of compositions is unclear as yet, and especially the interaction behind the compatibility is also indeterminate for healthy influence, has potential danger.
Bulbus Allii (Allium sativum L) is the Liliaceae allium, its underground bulb commonly used.Garlicin has wherein had report to can be used for relieving the effect of alcohol, but its effect remains further to be improved.
Summary of the invention
One of goal of the invention of the present invention is: at the problem of above-mentioned existence, provide a kind of definite effect, instant effect, side effect is little, cost is low relieving alcoholism and protecting the liver compositions.
The technical solution used in the present invention is such: a kind of relieving alcoholism and protecting the liver compositions, form by the component of following weight percentage ratio:
Puerarin 20-45%
Bulbus Allii 55%-80%.
Above-mentioned weight ratio is dry weight, and the moisture mass content is below 1% in each component.
The inventor finds by a large amount of experiments: puerarin adopts suitable ratio to cooperate with Bulbus Allii, can produce synergistic function for relieving alcoholism and protecting the liver.
As preferably: described Bulbus Allii is the Bulbus Allii ethanol extraction.
Further studies show that: the raw material Bulbus Allii is extracted by ethanol, remove the part water soluble ingredient in the Bulbus Allii, refining effective ingredient wherein makes that the relieving alcoholism and protecting the liver effect is more definite, also further alleviate the metabolism burden of liver, strengthened the metabolic function of liver.
Extracting method is: after Bulbus Allii is smashed to pieces, add aquiferous ethanol and soak, can be aided with ultrasonic acceleration and extract, can be aided with heating simultaneously, but heating-up temperature should not be higher than 60 ℃, and in order to improve extraction efficiency, extraction time can be controlled at 2 hours, filtered then, concentrate, drying, promptly.
Further: described Bulbus Allii ethanol extraction is that volumetric concentration is the ethanol extraction of 20%-55%.
The inventor finds that further volumetric concentration is the Bulbus Allii extract of the ethanol extraction of 20%-55%, and the effect that removes water soluble ingredient is better, and active constituent content wherein is higher.
Two of goal of the invention of the present invention is to provide the application of above-mentioned composition, and be included in preparation and be used for the treatment of application in the medicine of hepatic injury, and the application that is used for preventing the medicine of hepatic injury in preparation.
As preferably: described hepatic injury is because the hepatic injury that ethanol causes.
As preferably: add acceptable accessories and make capsule.Make the capsule agent and take and carry all easily, and cost is lower.
As preferably: add acceptable accessories and make tablet.Make tablets and carry all easily, and cost is lower.
In sum, owing to adopted technique scheme, the invention has the beneficial effects as follows: raw material is simple and easy to, and is with low cost; Have significant relieving alcoholism and protecting the liver effect, and few side effects, the drug effect safety and stability.
The specific embodiment
Below in conjunction with embodiment, the present invention is done detailed explanation.
In order to make purpose of the present invention, technical scheme and advantage clearer,, the present invention is further elaborated below in conjunction with embodiment.Should be appreciated that specific embodiment described herein only in order to explanation the present invention, and be not used in qualification the present invention.
Embodiment 1:
A kind of relieving alcoholism and protecting the liver compositions, form by following component:
Puerarin 20g, Bulbus Allii 80g; Mix homogeneously promptly.
Embodiment 2:
A kind of relieving alcoholism and protecting the liver compositions, form by the component of following weight percentage ratio:
Puerarin 32g, Bulbus Allii 68g; Mix homogeneously promptly.
Embodiment 3:
A kind of relieving alcoholism and protecting the liver compositions, form by the component of following weight percentage ratio:
Puerarin 40g, Bulbus Allii 60g; Mix homogeneously promptly.
Embodiment 4:
A kind of relieving alcoholism and protecting the liver compositions, form by the component of following weight percentage ratio:
Puerarin 45g, Bulbus Allii 55g; Mix homogeneously promptly.
Embodiment 5:
A kind of relieving alcoholism and protecting the liver compositions, form by the component of following weight percentage ratio:
Puerarin 32g, Bulbus Allii 68g, Bulbus Allii wherein is the Bulbus Allii extract that adopts volumetric concentration to extract than the ethanol that is 50%, adopts spray-dired method to carry out drying behind the extraction separation; Then with the puerarin mix homogeneously promptly.
Embodiment 6:
A kind of relieving alcoholism and protecting the liver compositions, form by the component of following weight percentage ratio:
Puerarin 45g, Bulbus Allii 55g, Bulbus Allii wherein is the Bulbus Allii extract that adopts volumetric concentration to extract than the ethanol that is 55%, adopts spray-dired method to carry out drying behind the extraction separation; Then with the puerarin mix homogeneously promptly.
The compositions of the foregoing description 1-6 can adopt the ordinary skill in the art to be prepared into capsule or tablet.
The test of sobering up of embodiment 7 mices
This test employing publication number is the test method that the embodiment embodiment 1 partly of the Chinese patent application of 102727571A puts down in writing, wherein
Test specimen comprises: experimental group 1-6(is respectively the prepared relieving alcoholism and protecting the liver compositions of the embodiment of the present application 1-6); (wherein " matched group 1 " is the embodiment embodiment 1 prepared Medicament for Alcoholism partly of the Chinese patent application of 102727571A for publication number to experimental control, " matched group 2 " negative contrast, be that normal saline is irritated stomach, " matched group 3 " for only containing the Medicament for Alcoholism of Radix Puerariae, and " matched group 4 " is for only containing the Medicament for Alcoholism that the Bulbus Allii extract that adopts volumetric concentration to extract than the ethanol that is 50% is made);
Subjects: 56 ° Red Star strong, colourless liquor distilled from sorghum, Hongxing Co., Ltd. Beijing; 200 of SPF level male mices, body weight 20 ± 2g;
Test method: (the 1-6 group is irritated the prepared relieving alcoholism and protecting the liver compositions of stomach the embodiment of the present application 1-6 respectively to be divided into 10 groups at random, the 7th group is aforesaid " matched group 1 ", the 8th group is aforesaid " matched group 2 ", the 9th group is aforesaid " matched group 3 ", the 10th group is aforesaid " matched group 4 ") 20 every group, except that the 8th group, the groundwater increment of every mouse test sample is the 0.2mg/10g body weight by dry weight basis, all the other are that the test method of embodiment 1 record of embodiment part of Chinese patent application of 102727571A is the same with publication number, the tolerance time that obtains and hold time as shown in table 1:
The table 1 mice result of the test of sobering up: (unit of time is min)
As can be seen from Table 1, the compositions that the application makes is compared with independent Radix Puerariae or Bulbus Allii extract, and is that the disclosed compositions of Chinese patent application of 102727571A is compared with publication number, has the unforeseeable good effect of relieving the effect of alcohol.
Embodiment 8 anti-acute alcohol liver loss tests
Test specimen is the same with the above embodiments 7, subjects is 200 of the male alcoholic hepatic injury mices of SPF level, body weight 20 ± 2g, be divided into 10 groups at random, wherein 1-6 organizes the compositions of administration the embodiment of the present application 1-6 respectively, the embodiment 3 prepared Medicament for Alcoholism of the embodiment part of the Chinese patent application that the 7th group of administration publication number is 102727571A, the 8th group of negative contrast, be that normal saline is irritated stomach, the 9th group is the Medicament for Alcoholism that administration only contains Radix Puerariae, the 10th group is that administration only contains the Medicament for Alcoholism that the Bulbus Allii extract that adopts volumetric concentration to extract than the ethanol that is 50% is made, all the other test methods and publication number are that the test method of embodiment 3 records of embodiment part of Chinese patent application of 102727571A is consistent, testing program difference wherein is: except that the 8th group, the dosage of every mouse test sample every day is all by the standard of 600mg/kgbw, the mice serum ALT that records at last, the AST activity, CHOL and TG content are as shown in table 2, SOD in the murine liver tissue that records, GSH activity and MDA content are as shown in table 3;
Table 2 mice serum ALT, AST activity, CHOL and TG content, wherein CHOL unit is (mg/dL), TG unit is (mmol/L)
SOD, GSH activity and MDA content in table 3 murine liver tissue, wherein SOD unit is (U/mg pro), and GSH unit is (mg/g pro), and MDA unit is (n mol/mg pro)
From table 2, table 3 as can be seen, the compositions that the application makes is compared with independent Radix Puerariae or Bulbus Allii extract, and is that the disclosed compositions of Chinese patent application of 102727571A is compared with publication number, has unforeseeable good hepatoprotective effect.
Embodiment 9 clinical trials
Choose 50 male volunteers, require: on average drink Chinese liquor 2L weekly at least, and have at least a drinking amount to surpass 500ml, be divided into two groups at random, every group 25 people, one group is adopted placebo, the capsule that another group adopts the compositions of the embodiment of the present application 5 preparations to make, take after drinking, Time of Administration is 3 months at every turn, after 3 months, taking has 20 people that in various degree hepatic injury is arranged in the group of placebo, and the compositions of taking the embodiment of the present application 5 preparation is made in capsular group, only has 2 people that slight hepatic injury is arranged, and proves that the application's the relieving alcoholism and protecting the liver effect of compositions is obvious.
Claims (8)
1. a relieving alcoholism and protecting the liver compositions is characterized in that, is made up of the component of following weight percentage ratio:
Puerarin 20-45%
Bulbus Allii 55%-80%.
2. relieving alcoholism and protecting the liver compositions as claimed in claim 1 is characterized in that: described Bulbus Allii is the Bulbus Allii ethanol extraction.
3. relieving alcoholism and protecting the liver compositions as claimed in claim 1 is characterized in that: described Bulbus Allii ethanol extraction is that volumetric concentration is the ethanol extraction of 20%-55%.
4. the described compositions of claim 3 is used for the treatment of application in the medicine of hepatic injury in preparation.
5. the described compositions of claim 3 is used for preventing the application of the medicine of hepatic injury in preparation.
6. as claim 4 or 5 described application, it is characterized in that: described hepatic injury is because the hepatic injury that ethanol causes.
7. as claim 4 or 5 described application, it is characterized in that: add acceptable accessories and make capsule.
8. as claim 4 or 5 described application, it is characterized in that: add acceptable accessories and make tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310157072.2A CN103211957B (en) | 2013-05-02 | 2013-05-02 | Alcohol relieving and liver protecting composition and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310157072.2A CN103211957B (en) | 2013-05-02 | 2013-05-02 | Alcohol relieving and liver protecting composition and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103211957A true CN103211957A (en) | 2013-07-24 |
| CN103211957B CN103211957B (en) | 2015-01-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310157072.2A Expired - Fee Related CN103211957B (en) | 2013-05-02 | 2013-05-02 | Alcohol relieving and liver protecting composition and application thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN103211957B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998578A (en) * | 2016-07-22 | 2016-10-12 | 赵月 | Liver-protecting composition |
| CN107509907A (en) * | 2017-10-18 | 2017-12-26 | 山西琪尔康翅果生物制品有限公司 | A kind of solid beverage with preventing alcoholic liver injury |
| CN108421027A (en) * | 2018-05-07 | 2018-08-21 | 深圳润邦之家生物科技有限公司 | A kind of relieving alcoholism and protecting liver product |
| CN108464996A (en) * | 2018-04-28 | 2018-08-31 | 乌林奇 | A kind of targeting adjusts pharmaceutical composition and its application of gene |
-
2013
- 2013-05-02 CN CN201310157072.2A patent/CN103211957B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 常亮等: "《葛根解酒含片的开发研制》", 《食品工业》 * |
| 曾涛: "《大蒜油与大蒜素对急性乙醇性肝损伤预防作用比较》", 《毒理学杂志》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998578A (en) * | 2016-07-22 | 2016-10-12 | 赵月 | Liver-protecting composition |
| CN106038951A (en) * | 2016-07-22 | 2016-10-26 | 赵月 | Liver-protecting capsules |
| CN106109873A (en) * | 2016-07-22 | 2016-11-16 | 赵月 | Liver-protecting combination is used for the application preventing or treating in the medicine of fatty liver in preparation |
| CN106138653A (en) * | 2016-07-22 | 2016-11-23 | 赵月 | A kind of liver-protecting tablet |
| CN107509907A (en) * | 2017-10-18 | 2017-12-26 | 山西琪尔康翅果生物制品有限公司 | A kind of solid beverage with preventing alcoholic liver injury |
| CN108464996A (en) * | 2018-04-28 | 2018-08-31 | 乌林奇 | A kind of targeting adjusts pharmaceutical composition and its application of gene |
| CN108421027A (en) * | 2018-05-07 | 2018-08-21 | 深圳润邦之家生物科技有限公司 | A kind of relieving alcoholism and protecting liver product |
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| Publication number | Publication date |
|---|---|
| CN103211957B (en) | 2015-01-28 |
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