CN103181389A - Sterilizing combination - Google Patents
Sterilizing combination Download PDFInfo
- Publication number
- CN103181389A CN103181389A CN2011104618141A CN201110461814A CN103181389A CN 103181389 A CN103181389 A CN 103181389A CN 2011104618141 A CN2011104618141 A CN 2011104618141A CN 201110461814 A CN201110461814 A CN 201110461814A CN 103181389 A CN103181389 A CN 103181389A
- Authority
- CN
- China
- Prior art keywords
- mandipropamid amine
- cyanogen frost
- downy mildew
- agent
- frost azoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940124530 sulfonamide Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses sterilizing combination. The combination comprises the following effective constituents: mandipropamid (A) and cyazofamid (B), with the mass ratio of 1:60 to 60:1. The combination has obvious synergistic effect and high control effect, is suitable for controlling various diseases on fruits and vegetables, and is particularly suitable for controlling downy mildew.
Description
Technical field
The present invention relates to a kind of bactericidal composition, relate in particular to a kind of bactericidal composition that contains mandipropamid amine.
Background technology
Downy mildew is by the microbial plant disease of Oomycete downy mildew in the fungi.Common downy mildew has downy mildew of cucurbits, naked oats dish downy mildew, downy mildew of garpe, tobacco downy mildew, downy mildew of lettuce, soybean downey mildew, downy mildew of sugarcane, peronophythora litchi etc.
This disease all can take place to each stage of results from seedling, and the spring is early summer or the easiest generation of continuous rainy weather in autumn not, can cause 30%～70% production loss when disease is serious.
Mandipropamid amine is acid amide fungicides.Its mechanism of action is for suppressing the biosynthesis of phosphatide, and leaf portion and fruit disease that exhausted big number is caused by oomycetes all have good preventive effect.The spore that is in the sprouting stage is had higher activity, and can suppress mycelia and grow up and sporulation.Can be absorbed rapidly by blade, and be rested in the leaf table wax coat, blade is shielded.
But the production that mandipropamid amine is present and use cost are all higher, and the resistance risk evaluation studies shows in addition, and long-term this medicament that uses separately has very big resistance risk.
The combination of the pesticide active ingredient of mandipropamid amine and other structure being carried out composite, is a kind of effective and efficient manner that solves cost and resistance problem in its single agent application process.The pesticide active ingredient of different structure shows three kinds of type of action, i.e. summation action, synergistic effect and antagonism after mixing usually.Compound synergic is well filled a prescription, and can improve actual control efficiency, reduces the usage amount of agricultural chemicals, also helps to delay the drug-fast generation of germ, is the important means of integrated control.
Also do not have mandipropamid amine and cyanogen frost azoles to use the report of preventing and treating disease with at present both at home and abroad, do not carry out any relevant test yet, more do not have production and the use of Related product.
Summary of the invention
It is obvious to the purpose of this invention is to provide a kind of synergistic effect, to the bactericidal composition that the downy mildew control efficiency is good, cost is low, resistance risk is low.
Another object of the present invention provides the application of this bactericidal composition.
The inventor is by a large amount of indoor biometrics and field control effectiveness tests, find that unexpectedly mandipropamid amine and cyanogen frost azoles is mixed in certain proportion after, diseases such as downy mildew are had significant synergistic effect.
Described cyanogen frost azoles Chinese another name: the match seat goes out; 4-chloro-2-cyano group-N, N-dimethyl-5-p-methylphenyl imidazoles-1-sulfonamide; Cyanogen azoles flusulfamide
Cyanogen frost azoles is the sulphaguanidine azoles fungicide, and its mechanism of action is the supply that the electronics transmission of mitochondrial cytochrome b c1 complex in the blocking-up Oomycete germ body comes interfering energy, and its binding site is the Q1 center of enzyme, does not have cross tolerance with other bactericide.
Mandipropamid amine and cyanogen frost azoles are bactericide well known in the art, can obtain by various commercial channel.
Technical scheme of the present invention is: a kind of bactericidal composition, contain active ingredient mandipropamid amine (A) and cyanogen frost azoles (B), and be 1: 60～60: 1 with (B) mass ratio (A), preferred proportion is 1: 35～35: 1, more the ratio of greater inequality example is 1: 20～10: 1.
The active ingredient of said composition cooperates with auxiliary agent and filler can be processed into any formulation that agricultural goes up permission, and formulation has suspending agent, aqueous emulsion, wetting powder, water dispersible granules preferably.
In the bactericidal composition of the present invention, active ingredient (A) and mass accumulation percentage composition (B) are 5%～80% preferably.
The formulation of above-mentioned bactericidal composition except comprise active ingredient (A) with (B), comprise that also auxiliary agent and other help the material of drug effect performance.Aqueous emulsion comprises organic solvent, dispersant, emulsifier and water; Suspending agent comprises water, dispersant, thickener, antifreezing agent and wetting agent; Wetting powder comprises wetting agent, dispersant and filler; Water dispersible granules comprises dispersant, disintegrant, filler and wetting agent.Below all be the various compositions of using or allow use in the pesticidal preparations always, be not particularly limited that concrete composition and consumption are determined by simple experiment according to the requirement of filling a prescription.For example:
Organic solvent can be selected isopropyl alcohol, dimethylbenzene, N, one or more in dinethylformamide, ring ethyl ketone, toluene, dimethyl sulfoxide (DMSO), methyl alcohol, ethanol, trimethyl cyclic ethylene ketone, N-octylpyrrolidone, N-methyl pyrrolidone, propyl alcohol, butanols, ethylene glycol, diethylene glycol, ethylene glycol monomethyl ether, butyl ether, ethyl acetate, the vegetable oil.
Dispersant can be selected sodium lignin sulfonate, calcium lignosulfonate, draws back powder, in the calcium dodecyl benzene sulfonate, polycarboxylate, alkyl benzene sulfonate calcium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, fatty acid glyceride APEO one or more.
Emulsifier can be selected agricultural emulsifier NO (phenyl phenol polyoxy ethyl ether), No. 1601 (phenethyl phenol polyoxy ethyl polypropylene-base ether) of farming breast, No. 500 (alkyl benzene calcium sulfonate) of farming breast, OP series phosphate (polyoxyethylene nonylphenol ether phosphate), No. 600 phosphates (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene rice ammonium sulfate, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, No. 400 (benzyl xylenol polyoxy ethyl ether) of farming breast, Nongru-700 number (alkyl phenolic resin polyoxy ethyl ether), No. 36 (phenethyl fluosite polyoxy ethyl ether) of peaceful breast, No. 1600 (phenethyl phenol polyoxy ethyl polypropylene-base ether) of farming breast, ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), No. 33 (alkylaryl polyoxyethylene polyoxypropylene ether) of farming breast, No. 34 (alkylaryl polyoxyethylene poly-oxygen propylene aether) of farming breast, sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), in the AEO series (the pure APEO of fat) one or more.
Antifreezing agent can be selected one or more in glycerine, urea, ethylene glycol, the propane diols.
Wetting agent can select that methyl naphthalene sulfonate formaldehyde condensate, lauryl sodium sulfate, Negel, alkyl benzene calcium sulfonate, tea are withered, spaonin powder, silkworm excrement, soapberry powder, bay alcohol radical sodium sulphate, washing powder, draw back in the powder one or more.
Disintegrant can be selected one or more in ammonium sulfate, urea, bentonite, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Thickener can be selected in xanthans, CMC, methylcellulose, Magnesiumaluminumsilicate, the polyvinyl alcohol one or more.
Filler can be selected one or more in White Carbon black, mountain range soil, precipitated calcium carbonate, talcum, imvite or convex-concave rod stone, float stone, brickbat, sepiolite or bentonite and non-adsorptivity calcium soil or the sand.
Composition described in the invention can the finished product preparation form provide, be that each material is pre-mixed before use in the composition, in addition, the composition of composition also can provide with single agent form, directly in bucket or jar, directly mix before the use, be diluted to required concentration then.
Bactericidal composition of the present invention can be used for preventing and treating on the crops such as various melon, strawberries, capsicum, Chinese cabbage, romaine lettuce, eggplant, lichee, potato, naked oats dish by fungus-caused plant diseases such as mastigomycetes, is particularly useful for preventing and treating downy mildew, eqpidemic disease, late blight etc.Composition of the present invention can be used by common method, and as cast, injection, spraying, dusting, scatter or be fuming, its amount of application is with weather condition or crop state variation.
The present invention compared with prior art, its advantage is: 1, the composition synergistic effect is obvious, preventive effect is compared with single agent and is significantly improved; 2, after drug effect improved, the effective ingredient consumption in field descended, and has reduced production and use cost, has reduced residue of pesticide and environmental pollution; 3, composition is made up of the active ingredient of different mechanism of action, and action site increases, and is conducive to overcome and delays the drug-fast generation of germ.
Embodiment
The pesticide active ingredient of different types of structure being carried out composite, is a kind of effective means that solves problem such as cost and resistance in the agricultural chemicals list agent application process at present.The pesticide active ingredient of different types of structure shows three kinds of type of action after mixing usually, and namely summation action, synergistic effect and antagonism act on but which kind of is specially, and be unpredictable, has only by a large amount of tests and just can know.Compound synergic is well filled a prescription, and can improve actual control efficiency, reduces the usage amount of agricultural chemicals, helps the generation of delaying drug resistance, is the important means of scientific prevention and cure damage by disease and insect.
The present composition has obvious role in synergism to Pseudoperonospora cubensis etc., and is not only the simple addition of two kinds of medicament effects, and this can be clear that from following biologicall test result of experiment very much.But the present invention is limited to these examples absolutely not.
Biologicall test example 1: composition is to the Toxicity Determination of downy mildew of cucurbits bacterium
Subjects is bacterium of downy mildew of cucumber (Pseudoperonospora cubensis).
Test method: with reference to " the agricultural industry criteria NY/T1156.11-2008 of the People's Republic of China (PRC) ".Choose potted plant two leaf period cucumber seedlings of growth potential unanimity, 5 basins are selected in each processing for use, number standby.Under 50PSI pressure, spray every basin 5mL with the Potter spray tower.Test is handled referring to table 1, table 2, and each medicament arranges 5 concentration gradients.Carrying out inoculum density behind the 24h is 3 * 10
5The bacterium of downy mildew of cucumber sporangia suspension of individual sporangium/mL.Be blank with the cucumber seedling that sprays the equivalent clear water.After the inoculation cucumber seedling being put into the illumination humidistat cultivates.Behind the 10d, according to the morbidity grade scale investigation disease index of cucumber downy mildew, and calculate control efficiency.
Cucumber downy mildew state of an illness grade scale:
0 grade: blade does not have scab;
1 grade: lesion area accounts for the area of whole blade below 5%;
3 grades: lesion area account for whole blade area 6%～10%;
5 grades: lesion area accounts for 11%～25% of whole blade area;
7 grades: lesion area accounts for 25%～50% of whole blade area;
9 grades: lesion area accounts for more than 50% of whole blade area.
The expection effectiveness of mixture of active principles (be theoretical control efficiency, %) use Colby formula is determined and is compared with observed effectiveness:
Colby formula: E=X+Y-X*Y/100
E: the active components A working concentration is a in composition, and the compositions contemplated when active component B working concentration is b is renderd a service.
X: the effectiveness when the active components A using dosage is a.
Y: the effectiveness when active component B using dosage is b.
The explanation mixture has synergistic effect when observed actual control efficiency surpasses the expection preventive effect.
Toxicity test result is referring to table 1 and table 2.
The independent reactive compound of table 1 is to the pot experiment measurement result of cucumber downy mildew
Table 2 mandipropamid amine and the composite pot experiment measurement result to cucumber downy mildew of cyanogen frost azoles
Result of the test shows that mandipropamid amine and cyanogen frost azoles composite control cucumber downy mildew in the certain proportion scope have synergistic effect.
In order to make purpose of the present invention, technical scheme and advantage clearer, the present invention describes with following concrete formulation examples, but the present invention is limited to these examples absolutely not.The following stated only is the present invention embodiment preferably, only in order to explain the present invention, can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that all any modifications of making within the spirit and principles in the present invention, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Suspending agent embodiment
The ratio of each component such as active ingredient, dispersant, defoamer, thickener and water in prescription mixed, after sand milling or high speed shear, obtain semi-finished product, add water after the analysis and mix filtration and namely get suspending agent.
FORMULATION EXAMPLE 1,30.5% mandipropamid amine cyanogen frost azole suspending agent
Mandipropamid amine 30%, cyanogen frost azoles 0.5%, calcium lignosulfonate (dispersant) 6%, alkylphenol polyoxyethylene 6% (wetting agent), propane diols 2% (antifreezing agent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%.
FORMULATION EXAMPLE 2,48.8% mandipropamid amine cyanogen frost azole suspending agent
Mandipropamid amine 0.8%, cyanogen frost azoles 48%, sodium lignin sulfonate (dispersant) 6%, alkylphenol polyoxyethylene 6% (wetting agent), propane diols 2% (antifreezing agent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%.
FORMULATION EXAMPLE 3,30% mandipropamid amine cyanogen frost azole suspending agent
Mandipropamid amine 15%, cyanogen frost azoles 15%, calcium lignosulfonate (dispersant) 6%, alkylphenol polyoxyethylene 6% (wetting agent), propane diols 2% (antifreezing agent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%.
FORMULATION EXAMPLE 4,18% mandipropamid amine cyanogen frost azole suspending agent
Mandipropamid amine 17.5%, cyanogen frost azoles 0.5%, sodium lignin sulfonate (dispersant) 6%, alkylphenol polyoxyethylene 6% (wetting agent), propane diols 2% (antifreezing agent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%.
FORMULATION EXAMPLE 5,36% mandipropamid amine cyanogen frost azole suspending agent
Mandipropamid amine 1%, cyanogen frost azoles 35%, calcium lignosulfonate (dispersant) 6%, alkylphenol polyoxyethylene 6% (wetting agent), propane diols 2% (antifreezing agent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%.
FORMULATION EXAMPLE 6,22% mandipropamid amine cyanogen frost azole suspending agent
Mandipropamid amine 20%, cyanogen frost azoles 2%, sodium lignosulphonate's (dispersant) 6%, alkylphenol polyoxyethylene 6% (wetting agent), propane diols 2% (antifreezing agent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%.
Aqueous emulsion embodiment
By each set of dispense ratio, active ingredient is dissolved in solvent and the cosolvent, add surfactant, mix and make oil phase.With water-soluble component and the mixed water that gets of water, again water is added in the oil phase, the limit edged stirs, and makes aqueous emulsion.
FORMULATION EXAMPLE 7,5% mandipropamid amine cyazofamid aqueous emulsion
Mandipropamid amine 2.5%, cyanogen frost azoles 2.5%, DMF (solvent) 5%, cyclohexanol (solvent) 10%, glycerine (antifreezing agent) 5%, phenethyl phenol polyethenoxy ether (emulsifier) 10%, calcium dodecyl benzene sulfonate (wetting agent) 5%, water are supplemented to 100%.
FORMULATION EXAMPLE 8,21% mandipropamid amine cyazofamid aqueous emulsion
Mandipropamid amine 1%, cyanogen frost azoles 20%, turpentine oil (vegetable oil solvent) 5%, Jatropha curcas oil (vegetable oil solvent) 10%, glycerine (antifreezing agent) 5%, phenethyl phenol polyethenoxy ether (emulsifier) 10%, calcium dodecyl benzene sulfonate (wetting agent) 5%, water are supplemented to 100%.
Water dispersible granules embodiment
Pesticide active ingredient, auxiliary agent and filler are mixed in proportion, pulverize through air-flow, add the water of 15-20% then, make the water dispersible granules product through kneading, granulation, drying, screening.Capital equipment: mixer, airslide disintegrating mill, kneader, Squeezinggranulator, drying equipment (drying room or fluid bed).
FORMULATION EXAMPLE 9,80% mandipropamid amine cyanogen frost azoles water dispersible granules
Mandipropamid amine 40%, cyanogen frost azoles 40%, neopelex 4% (wetting agent), sodium lignin sulfonate 10% (dispersant), ammonium sulfate 3% (disintegrant), kaolin (filler) are to 100%.
FORMULATION EXAMPLE 10,50% mandipropamid amine cyanogen frost azoles water dispersible granules
Mandipropamid amine 5%, cyanogen frost azoles 45%, neopelex 4% (wetting agent), sodium lignin sulfonate 10% (dispersant), ammonium sulfate 3% (disintegrant), diatomite (filler) are to 100%.
Wetting powder embodiment
Pesticide active ingredient, auxiliary agent, filler are mixed after air-flow is pulverized mixed wetting powder in proportion again.Capital equipment: mixer, airslide disintegrating mill.
FORMULATION EXAMPLE 11,30% mandipropamid amine cyanogen frost azoles wetting powder
Mandipropamid amine 10%, cyanogen frost azoles 20%, bay alcohol radical sodium sulphate 4% (wetting agent), mersolates 7% (dispersant), white carbon 8% (filler), kaolin (filler) are to 100%.
FORMULATION EXAMPLE 12,40% mandipropamid amine cyanogen frost azoles wetting powder
Mandipropamid amine 35%, cyanogen frost azoles 5%, bay alcohol radical sodium sulphate 4% (wetting agent), mersolates 7% (dispersant), white carbon 8% (filler), talcum powder (filler) are to 100%.
FORMULATION EXAMPLE 13,25% mandipropamid amine cyanogen frost azoles wetting powder
Mandipropamid amine 20%, cyanogen frost azoles 5%, bay alcohol radical sodium sulphate 4% (wetting agent), mersolates 7% (dispersant), white carbon 8% (filler), White Carbon black (filler) are to 100%.
Field application examples 1: mandipropamid amine and the composite field control effectiveness test to cucumber downy mildew of cyanogen frost azoles
Test site Guangdong Zhong Shan.Test medicine and consumption see Table 3, and 20 square metres of each residential quarter areas are repeated in 4 residential quarters of every processing.Carry out the dispenser first time at the disease initial stage of origination, even spraying till being sprayed onto blade and dripping, is treated to blank with clear water.Execute medicine for the second time after 7 days.The incidence of 7 days investigation cucumber downy mildews behind the medicine before first time medicine and for the second time.5 samplings are adopted in every residential quarter, every some investigation two strains, and all blades are investigated in every strain, and the percentage that accounts for whole leaf area with lesion area comes the classification record.Calculate and respectively handle disease index and control efficiency.
Grade scale:
0 grade: no scab;
1 grade: lesion area accounts for below 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-15% of whole leaf area;
5 grades: lesion area accounts for the 16%-25% of whole leaf area;
7 grades: lesion area accounts for the 26%-50% of whole leaf area;
9 grades: lesion area accounts for more than 50% of whole leaf area.
The drug effect computational methods:
As can be seen from Table 3: mandipropamid amine, the agent of cyanogen frost azoles list are respectively 78.3%, 76.7% to the preventive effect of cucumber downy mildew, and embodiment of the invention bactericidal composition all is significantly increased on preventive effect, and minimum preventive effect is 86.3%, has been up to 92.4%.The result of field trial shows that fully mandipropamid amine and the composite back of cyanogen frost azoles have remarkable role in synergy to cucumber downy mildew, and under the situation that the more single agent of mu effective ingredient consumption reduces, control efficiency significantly improves.Therefore, the present composition have reduce cost, the beneficial effect of delaying drug resistance, minimizing spraying times and residue of pesticide, expanding prevention spectrum.
Table 3 mandipropamid amine and the composite field test results to cucumber downy mildew of cyanogen frost azoles
Field application examples 2: mandipropamid amine and the composite field control effectiveness test to naked oats dish downy mildew of cyanogen frost azoles
Test site Shenzhen Long Gang.Test medicine and consumption see Table 4, and 20 square metres of each residential quarter areas are repeated in 4 residential quarters of every processing.Carry out the dispenser first time at the disease initial stage of origination, even spraying till being sprayed onto blade and dripping, is treated to blank with clear water.Execute medicine for the second time after 7 days.The incidence of 7 days investigation naked oats dish downy mildew behind the medicine before first time medicine and for the second time.5 samplings are adopted in every residential quarter, every some investigation two strains, and all blades are investigated in every strain, and the percentage that accounts for whole leaf area with lesion area comes the classification record.Calculate and respectively handle disease index and control efficiency.
Grade scale and drug effect computational methods are with field application examples 1.
As can be seen from Table 4: mandipropamid amine, the agent of cyanogen frost azoles list are respectively 79.7%, 77.2% to the preventive effect of naked oats dish downy mildew, and embodiment of the invention bactericidal composition all is significantly increased on preventive effect, and minimum preventive effect is 86.8%, has been up to 93.8%.The result of field trial shows that fully mandipropamid amine and the composite back of cyanogen frost azoles have remarkable role in synergy to naked oats dish downy mildew, and under the situation that the more single agent of mu effective ingredient consumption reduces, control efficiency significantly improves.Therefore, the present composition have reduce cost, the beneficial effect of delaying drug resistance, minimizing spraying times and residue of pesticide, expanding prevention spectrum.
Table 4 mandipropamid amine and the composite field test results to naked oats dish downy mildew of cyanogen frost azoles
Claims (6)
1. bactericidal composition is characterized in that: containing active ingredient mandipropamid amine (A) and cyanogen frost azoles (B), is 1: 60～60: 1 with (B) mass ratio (A).
2. bactericidal composition according to claim 1 is characterized in that: be 1: 35～35: 1 with (B) mass ratio (A).
3. bactericidal composition according to claim 2 is characterized in that: be 1: 20～10: 1 with (B) mass ratio (A).
4. bactericidal composition according to claim 1 is characterized in that: (A) is 5%～80% with (B) mass accumulation percentage composition in the composition.
5. bactericidal composition according to claim 1, it is characterized in that: the active ingredient of said composition and auxiliary agent and filler are processed into suspending agent, aqueous emulsion, wetting powder or water dispersible granules.
6. the application of bactericidal composition according to claim 1 on control gourd, fruit and vegetable downy mildew.
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| CN105028417A (en) * | 2015-06-08 | 2015-11-11 | 柳州市天姿园艺有限公司 | Composition for preventing and treating phytophthora root rot of cymbidium kanran |
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Application publication date: 20130703 |