CN103169905A - Traditional Chinese medicine capsule preparation for treating lung-heart disease and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation capsule for treating cor pulmonale, which is prepared from the following raw materials in parts by weight: Coix seed 20-45, reed rhizome 20-45, peach kernel 6-12, wax gourd kernel 20-45, Sea pumice 20-45, Gualou kernel 20-26, Tinglizi 20-30, Baibu 6-12, almond 6-15, ginseng 2-6, Ophiopogon japonicus 12-25, Schisandra 3-9, Fritillaria 6 -12, Anemarrhena 10-20, borneol 0.02-0.3. The selected materials are all traditional Chinese medicine materials, without any toxic and side effects; this formula is completely in line with the principles of traditional Chinese medicine and the physical and mental characteristics of heart disease patients. Under the premise of the general principle, different formulas can be formulated according to different groups of people, with different functions. The source of medicine is easy to obtain, and the cost of medicinal materials is low, which can reduce the burden on patients.

Description

Traditional Chinese medicine preparation capsule for treating cor pulmonale and preparation method thereof

This application is a divisional application: original application number: 201210091238.0, application date: 2012.3.31, invention name: traditional Chinese medicine preparation for treating pulmonary heart disease and its preparation method.

technical field

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for treating pulmonary heart disease and a preparation method thereof.

Background technique

The most common chronic pulmonary heart disease is chronic hypoxic pulmonary heart disease, also known as obstructive emphysematic heart disease, referred to as cor pulmonale, which refers to the resistance of pulmonary circulation caused by chronic lesions of the lung thorax or pulmonary artery. Increased, resulting in pulmonary hypertension and right ventricular hypertrophy, a type of heart disease with or without right heart failure. Pulmonary heart disease is common disease in my country, frequently-occurring disease.

The early manifestations of chronic pulmonary heart disease are long-term cough, expectoration and dyspnea in varying degrees, especially after activities or in cold seasons. In the early stage of cor pulmonale, the cardiopulmonary function is in the stage of replacement, the patient has no specific symptoms, and the patient may be asymptomatic when quiet, so the disease is not easy to attract people's attention. However, as long as the following situations occur, it often indicates that you have cor pulmonale: 1. Long-term repeated cough and expectoration. 2. The condition worsens every cold season, the cough intensifies, and the sputum volume increases, thickens or turns yellow. 3. Symptoms such as shortness of breath, shortness of breath, heart palpitations, precordial pain, fatigue, chest tightness and other symptoms during light activities such as going up stairs or walking briskly can be improved after rest. 4. The fingertips, lips and the surrounding areas of the lips are bluish purple. 5. Accelerated heart rate and arrhythmia. Cor pulmonale can lead to cardiac changes: hypertrophy of the right ventricle, thickening of the ventricular wall, expansion of the heart cavity, dilatation of the conus pulmonary artery, hypertrophy and atrophy of myocardial fibers, interstitial edema, and focal necrosis, which is replaced by fibrous tissue after necrosis . Some patients may be combined with coronary atherosclerotic lesions.

The treatment of cor pulmonale is symptomatic treatment such as antitussive, expectorant, asthma and anti-infection. Or use drugs to improve the body's immunity, such as nucleic acid casein injection (or expired measles attenuated vaccine), subcutaneous or intramuscular injection and (or) atomized inhalation, 2-4ml each time, twice a week, or nucleic acid casein oral solution 10ml/bottle, 3 times/d, 3-6 months as a course of treatment. Subcutaneous injection of bronchitis vaccine, immune ribonucleic acid, intramuscular injection of placental lipopolysaccharide, ginseng, transfer factor, oral administration of levamisole, etc.

Compared with Western medicine and Western medicine, TCM treatment has less toxic and side effects, and is more favored by the majority of medical workers and patients. The Chinese patent document of authorized announcement number CN 1294926C (application number 200410015856.2) provides a formula and preparation method of a traditional Chinese medicine composition for treating pulmonary heart disease, including raw materials and auxiliary materials. 1-5 parts of seedlings, 1-5 parts of Rhizoma Chuanxiong, 1-5 parts of Kuolou skin and auxiliary materials. The Chinese patent document of authorized announcement number CN 100496530C (application number 200410018562.5) involves a traditional Chinese medicine composition for treating pulmonary heart disease, including Chinese herbal medicine Tinglizi and Chuanxiong. 3 parts, chuanxiong or its extract 1-2 parts and the most suitable auxiliary materials. Publication number CN 101229267A (application number 200810056134.X) relates to a pharmaceutical composition for treating cor pulmonale and rheumatic heart disease and its preparation method. , Bupleurum, Jishi and Licorice.

Although the medicines provided in the prior art have more or less curative effects on the treatment of cor pulmonale, some prescriptions will more or less bring certain toxic and side effects to the patient's gastrointestinal tract, liver and kidney. Generally speaking, there is no ideal and exact traditional Chinese medicine treatment drug for the treatment of cor pulmonale at present.

Contents of the invention

Aiming at the deficiencies of the prior art, the object of the present invention is to provide a Chinese medicine preparation for treating pulmonary heart disease which is simple to prepare, convenient to take, easy to carry, and easy to take for a long time, and a preparation method thereof. The traditional Chinese medicine composition has definite curative effect and no toxic and side effects.

Technical scheme of the present invention is:

The traditional Chinese medicine preparation for treating cor pulmonale is prepared from the following raw materials, all in parts by weight: coix seed 20-45, reed root 20-45, peach kernel 6-12, wax gourd kernel 20-45, sea pumice 20-45, melon Betel 20-26, Tinglizi 20-30, Baibu 6-12, Almond 6-15, Ginseng 2-6, Ophiopogon japonicus 12-25, Schisandra 3-9, Fritillary 6-12, Anemarrhena 10- 20, borneol 0.02-0.3. In the preferred scheme, coix seed 25-35, reed root 25-35, peach kernel 9-10, wax gourd kernel 25-35, sea pumice 25-35, gualou kernel 22-24, Tinglizi 22-28, basil 9-10, almond 9-12, ginseng 3-5, Ophiopogon japonicus 15-20, Schisandra 5-8, Fritillaria 9-10, Anemarrhena 12-15, borneol 0.08-0.2 (preferably 0.1-0.15). More preferably, coix seed 30, reed root 30, peach kernel 9.5, wax gourd kernel 30, sea pumice 30, melon seeds 23, Tinglizi 26, centipede 9.5, almond 10, ginseng 4, Ophiopogon japonicus 18, Schisandra 6 , Fritillaria 9.5, Anemarrhena 13, Borneol 0.12.

For the aforementioned Chinese medicine preparation, preferably, the Chinese medicine preparation is made into pharmaceutically acceptable water, powder, tablet or capsule.

The preparation method of described water preparation is:

(1) Grind coix seed, reed root, peach kernel, wax gourd kernel, pumice stone, melon seeds, Tinglizi, Baibu, almond, ginseng, Ophiopogon japonicus, Schisandra, Fritillaria and Anemarrhena, and pass through 120-140 mesh Sieve (preferably 130 mesh sieve) to get fine powder;

(2) Mix the fine powder obtained in step (1) evenly, put it in a transparent bag, and soak it in cold boiled water at a temperature of 20-40°C (preferably 30°C) for 6-8 hours (preferably 7 hours), and the water consumption is 3-4 times (preferably 3.5 times) the weight of the fine powder;

(3) Heat to boiling for 0.6-1.2 hours (preferably 0.8-1.0 hours), then take out the transparent bag, and the obtained liquid is concentrated to 1/2-1/3 of the original volume to obtain a concentrated solution;

(4) Grinding the borneol, adding it to the concentrated solution obtained in step (3), and aseptically packaging it to obtain the Chinese medicine composition water.

The preparation method of the powder is as follows: crush each raw material through a 60-100 mesh sieve (preferably a 80-85 mesh sieve) to obtain the traditional Chinese medicine composition powder.

The preparation method of the tablet is: the powder of the traditional Chinese medicine composition obtained in claim 6 is measured according to 0.2-0.3g/tablet (preferably 0.25g/tablet), and pressed into a round or other form of tablet according to the processing and preparation method of the tablet dosage form.

The preparation method of the tablet is as follows: measure 0.2-0.3 g/grain (preferably 0.25 g/grain) of the traditional Chinese medicine composition powder obtained in claim 6, and process it into a capsule dosage form according to the capsule preparation method.

The pharmacology of main Chinese medicine raw material used in the present invention is as follows:

Coix seed: nature and flavor: sweet, light. cold. Meridians returned: return spleen, stomach, lung meridians. Efficacy: invigorating the spleen and expelling dampness, eliminating numbness and relieving diarrhea, clearing away heat and expulsion of pus. Indications: For edema, beriberi, dysuria, arthralgia due to dampness contracture, diarrhea due to spleen deficiency, lung pain, intestinal abscess; flat wart. "Compendium of Materia Medica": coix seed is not as good as the second method to help dryness in dehumidification, it is not as good as Qin in clearing away heat, and it is not as good as qin, which can damage yin, and it is not as good as ginseng in replenishing qi. However, its taste is mild and its power is slow. If you don’t get along with others to help others, and if you gather thickly to invest in it, can you hope that it will be effective if you play it? "New Compendium of Materia Medica": coix seed is the best at diuretic, and will not deplete the qi of true yin. It is most suitable for those with dampness in the lower body. . Therefore, in case of water-dampness, one or two liang of barley is the king, and the taste of invigorating the spleen and dehumidification will not be slow to be effective. If the mild smell of its scent is used lightly, it will not be beneficial.

Reed root: nature and flavor: sweet, cold. Meridian distribution: return lung, stomach meridian. Efficacy: clearing away heat and promoting body fluid, eliminating restlessness, relieving vomiting, diuretic. Indications: For pyretic disease polydipsia, vomiting due to stomach heat, cough due to lung heat, pulmonary abscess with vomiting of pus, hot stranguria with astringent pain.

Peach kernel: nature and flavor: bitter, sweet, flat. Meridians Guixin, Liver, and Large Intestine. Efficacy: Promoting blood circulation and removing blood stasis, moistening intestines and laxative. Indications: For amenorrhea. Dysmenorrhea. Abdominal mass in the abdomen, mass in the abdomen, injury from falling, intestinal dryness and constipation. Modern research, it contains amygdalin (Amygdalin), bitter almond enzyme (Emulsin), allantoinase (Allantoinase), lactase (Lactase), vitamin B1. Volatile oil, fatty oil, the oil mainly contains oleic acid glyceride and a small amount Glyceryl Linoleate. Laetrile enzymes include amygdalase (Amygdalase) and cherry leaf enzyme (Prunase). Amygdalin in peach kernels, like amygdalin in almonds, produces hydrocyanic acid, benzaldehyde, and glucose after enzymatic or acid hydrolysis.

Wax gourd kernel: the seed of winter melon, a plant of Cucurbitaceae. Sweet in nature, cool. Cold, non-toxic. Enter the foot Jueyin meridian. Can clear the lung and resolve phlegm; eliminate carbuncle and discharge pus; dampness. Mainly phlegm-heat cough; pulmonary abscess; intestinal abscess; white turbidity; leukorrhea; beriberi; edema; stranguria syndrome.

Sea pumice: alias water flower ("Materia Medica Supplements"), white pumice, sea pumice, sea stone ("Danxi Xinfa"), blister stone ("Treasure of Eastern Medicine"), sea pumice, pumice ("Jade Catalpa "Medicine solution"), pumice stone ("Yi Lin Zhuan Yao"), morel stone ("Compilation of medicinal materials"). Meridian distribution: lung; kidney; liver; large intestine meridian. Nature and flavor: salty, cold. Clearing lung-fire, resolving old phlegm, softening and hardening, treating stranguria. Treatment of phlegm heat, asthma, cough, old phlegm accumulation, goiter, scrofula, gonorrhea, hernia, sores, and nebula. Clearing the lungs and resolving phlegm, softening and resolving hard masses. For lung-heat cough, thick yellow phlegm, hemoptysis, bronchitis, lymph node tuberculosis. Medicinal materials are divided into sea pumice and sea stone flowers. Sea pumice is a stone formed by magma erupted from a volcano; sea stone flower is the dry skeleton of Costazia aculeata Canu et Bassler or Costazia costazii Audouin. Sea pumice can be harvested throughout the year. It is fished out from the sea, cleaned and dried in the sun. Haishihua is fished out from the sea in summer and autumn, washed with water to remove salt and sediment, and dried in the sun.

Gualou (ren): slightly gas, sweet, slightly bitter. "Compendium of Materia Medica" volume 18 contains: Gualou "moistens lung dryness, reduces fire, cures cough, clears phlegm, relieves thirst, relieves stool, and eliminates carbuncle and sore." Modern medical research has confirmed that Trichosanthes contains 16.8% unsaturated fatty acids, 5.46% protein, 17 kinds of amino acids, three saponins, multivitamins and 16 kinds of trace elements such as calcium, iron, zinc and selenium. Eating Trichosanthes (ren) has the effect of dilating the coronary arteries of the heart and increasing coronary flow; it has obvious protective effects on acute myocardial ischemia; it has a strong inhibitory effect on the proliferation of isolated choriocarcinoma cells and HIV.

Tinglizi: nature and flavor: pungent, bitter, severe cold. Meridian distribution: return lung, bladder meridian. Efficacy: Contaminated lungs relieve asthma, promote water and reduce swelling. Indications: For phlegm obstructing the lungs, wheezing and coughing with excessive phlegm, distension of the chest and hypochondrium, inability to lie down, chest and abdomen edema, dysuria; edema in cor pulmonale.

Baibu: Nature and flavor: sweet, bitter, slightly warm. Meridian return: return to the lung meridian. Efficacy: Nourish lungs, lower qi, relieve cough, kill insects. Indications: For chronic cough, tuberculosis cough, pertussis; externally for head lice, body lice, pinworms, pruritus vulvae. Moisturizing the lungs and relieving cough. For cough due to yin deficiency.

Almond (bitter almond) Nature and flavor: bitter, slightly warm; slightly poisonous. Meridian distribution: return lung, large intestine meridian. Efficacy: lowering qi, relieving cough and asthma, moistening intestines and laxative. Indications: For cough and asthma. Chest full of phlegm, blood deficiency and body fluid dryness, intestinal dryness and constipation.

Borneol (preferably natural borneol): Sex is hard and cool. Can "cure sore throat, brain pain, snort, toothache, typhoid fever, tongue out, children's acne depression. Open all orifices, dispel stagnant fire." ("Compendium").

Ginseng: nature and flavor: sweet, slightly bitter, flat. Meridian return: return spleen, lung, heart meridian. Efficacy: Tonify vital energy, restore pulse and solidify, nourish spleen and lung, promote body fluid, and soothe the nerves. Indications: Deficiency of the body, cold limbs, weak pulse, spleen deficiency, lack of food, lung deficiency, asthma and cough, thirst for body fluid wounds, internal heat and thirst, prolonged illness and deficiency, palpitations and insomnia, Yang layer official cold; heart failure, cardiogenic Sexual shock.

Ophiopogon japonicus: nature and flavor: sweet, slightly bitter, slightly cold. Meridian distribution: Guixin, lung, stomach meridians. Efficacy: Nourishing yin and promoting body fluid, nourishing the lungs and clearing the heart. Indications: For dry cough due to lung dryness. Asthenic tuberculosis cough, thirsty fluid wound, upset and insomnia, internal heat and thirst, intestinal dryness and constipation; pharyngeal diphtheria.

Schisandra: nature and flavor: sour, sweet, warm. Meridian return: return lung, heart, kidney meridian. Efficacy: Astringent and astringent, nourishing qi and promoting body fluid, invigorating kidney and calming heart. Indications: For chronic cough and shortness of breath, nocturnal nocturnal emission, enuresis, frequent urination, chronic diarrhea, spontaneous sweating, night sweats, thirsty wounds, shortness of breath, deficiency of pulse, internal heat and quenching thirst, palpitations and insomnia.

Fritillaria (Zhejiang Fritillaria): Nature and flavor: bitter, cold. Meridian return: return lung, heart channel. Efficacy: clearing away heat and dissipating stagnation. Resolving phlegm and relieving cough, curing mainly: used for wind-heat invading the lung, cough due to phlegm-fire, lung abscess, mastalgia, scrofula, sore.

Anemarrhena: nature and flavor: bitter, sweet, cold. Meridian return: return lung, stomach, kidney channel. Efficacy: clearing heat and purging fire, promoting body fluid and moistening dryness. Indications: For exogenous febrile diseases. High fever and polydipsia, dry cough due to lung heat, hot flashes due to bone steaming, internal heat quenching thirst, intestinal dryness and constipation.

The traditional Chinese medicine composition provided by the invention has scientific prescriptions, simple preparation methods of various dosage forms, and the obtained products are convenient to take and carry. In addition, the excellent effect of the present invention is also manifested in:

1. The selected materials are all traditional Chinese medicine materials without any toxic and side effects;

2. This prescription is completely in line with the principles of traditional Chinese medicine and the physical and mental characteristics of patients with pulmonary heart disease and heart disease. Under the premise of the general principle, different prescriptions can be formulated according to different groups of people, with different functions.

3. The source of medicine is easy to obtain, and the cost of medicinal materials is low, which can reduce the burden on patients.

Detailed ways

The technical solutions of the present invention will be described in detail below in conjunction with the examples and experimental examples, but the scope of protection is not limited thereto.

Example 1 The traditional Chinese medicine preparation for the treatment of cor pulmonale is prepared from the following raw materials, all in parts by weight (1 kg per part): coix seed 20, reed rhizome 20, peach kernel 6, wax gourd kernel 20, pumice stone 20, gualou kernel 20, Tinglizi 20, Baibu 6, almond 6, ginseng 2, Ophiopogon japonicus 12, Schisandra 3, Fritillaria 6, Anemarrhena 10, borneol 0.02. The preparation method of the above-mentioned Chinese medicine preparation water for the treatment of cor pulmonale:

(1) Grind coix seed, reed root, peach kernel, wax gourd kernel, sea pumice, melon seeds, Tinglizi, basil, almonds, ginseng, Ophiopogon japonicus, Schisandra, Fritillaria and Anemarrhena, and pass through a 140-mesh sieve. get fine powder;

(2) Mix the fine powder obtained in step (1) evenly, put it in a transparent bag, and soak it in cold boiled water at a temperature of 40°C for 8 hours, and the water consumption is 4 times the weight of the fine powder;

(3) Heat to boiling, take out the permeable bag after 1.2 hours, and concentrate the obtained liquid to 1/2-1/3 of the original volume to obtain a concentrated liquid;

(4) Grinding the borneol, adding it to the concentrated solution obtained in step (3), and aseptically packaging it to obtain the Chinese medicine composition water.

The taking method of water preparation of the present invention: water preparation is a course of treatment for 7 days, takes twice (warming) every day, each 350m1-500m1.

Example 2 The traditional Chinese medicine preparation for treating cor pulmonale is prepared from the following raw materials, all in parts by weight (70g per part): coix seed 45, reed rhizome 45, peach kernel 12, wax gourd kernel 45, pumice stone 45, gualou kernel 26, Tinglizi 30, Baibu 12, almond 15, ginseng 6, Ophiopogon japonicus 25, Schisandra 9, Fritillaria 12, Anemarrhena 20, borneol 0.3.

The preparation method of the above-mentioned traditional Chinese medicine preparation powder for the treatment of cor pulmonale is: each crude drug is pulverized through a 100-mesh sieve to obtain a Chinese medicine composition powder, and the powder is divided into 0.4g/bag; adopt 2-3 times a day, one bag each time, use Take it with warm water, one course of treatment every 7 days.

Typical case: xxx, male, 87 years old, a retired doctor. Since 1964, there has been no obvious cause for paroxysmal cough, sputum, white mucus sputum, and sometimes blood in the sputum. At that time, he was diagnosed as "bronchitis". After penicillin treatment ease. Afterwards, the weather became cooler and recurred in winter and spring, and improved after taking antibiotics and cough medicine. After 1995, the cough and sputum became more severe, and it became more severe in the morning, and the white foamy sputum was coughed up. After activities such as climbing stairs and walking quickly, I felt palpitations and shortness of breath, which could be relieved after rest. Yellow purulent sputum, small amount, difficult to cough up, accompanied by obvious shortness of breath, palpitations and edema of both lower extremities. He was treated with cefoperazone, lomefloxacin, aminophylline and traditional Chinese medicine successively in the local area, but the improvement was not obvious, and he also felt short of breath when walking on flat roads. 10 days ago, after catching a cold, I felt heart palpitations and shortness of breath worsened again. I couldn’t lie on my back at night. The amount of urination decreased. I had a low-grade fever. The body temperature fluctuated between 37.5°C and 38.0°C. I coughed and coughed up white mucus sputum. , chest pain and hemoptysis, the symptoms were not relieved after inhaling oxygen at home and taking antipyretic, cough-relieving and phlegm-reducing medicines. The outpatient was admitted to the hospital with "chronic bronchitis, emphysema, pulmonary heart disease and respiratory failure". He used to be healthy and had a history of smoking for 55 years, 20--30 sticks a day. He quit smoking in 1995. No drinking habit.

Take the Chinese medicine preparation powder for the treatment of cor pulmonale obtained in this embodiment, one bag each time, 3 times a day, take after mixing with warm boiled water, 7 days a course of treatment. After taking it for 21 days, the chest pain and cough were relieved, and the upset in the heart was also relieved. There was no discomfort when taking it, and he felt healed.

Example 3 The traditional Chinese medicine preparation for treating cor pulmonale is prepared from the following raw materials, all in parts by weight (50 g per part): Coix seed 35, reed rhizome 35, peach kernel 10, winter melon kernel 35, pumice stone 35, gualou kernel 24, Tinglizi 28, Baibu 10, almond 12, ginseng 5, Ophiopogon japonicus 20, Schisandra 8, Fritillaria 10, Anemarrhena 15, borneol 0.2.

The preparation method of the traditional Chinese medicine preparation tablet for treating cor pulmonale is as follows: crush each raw material through a 60-mesh sieve to obtain the traditional Chinese medicine composition powder. The obtained traditional Chinese medicine composition powder is measured according to 0.25g/tablet, and pressed into round or other forms of tablet dosage forms according to the processing and preparation method of the photographic preparation. Tablets are used 3 times a day, 2-4 tablets each time, mixed with warm water, a course of treatment is 7 days.

Typical case: xxx, female, 54 years old, from Hanzhong, Shaanxi. The patient has a history of asthma for more than 30 years, and usually coughs frequently, and feels wheezing, shortness of breath and suffocation. In January 2006, the symptoms suddenly worsened, sweating profusely, lower extremity edema, and pale face. He went to the local hospital for emergency treatment. At that time, the heart function was grade 4, and the echocardiography showed that the whole heart was enlarged, heart failure, and pulmonary A hypertension. Due to the critical condition, the local doctor told the patient that there was little hope for treatment.

In order to seek better treatment, the patient began to take the Chinese medicine preparation tablet obtained in this embodiment for the treatment of cor pulmonale in March 2008, using twice a day, each 4 tablets, mixed with warm water, 7 days a course of treatment. After taking it for 21 days, the precordial pain and cough were alleviated, fatigue and weakness were also relieved, the appetite increased, and the energy was restored. After taking it for 5 months, the electrocardiogram showed that the coronary blood supply was significantly improved. After taking it for 12 months, the patient felt healed.

Example 4 The traditional Chinese medicine preparation for the treatment of cor pulmonale is prepared from the following raw materials, all in parts by weight (25g per part): coix seed 25, reed root 25, peach kernel 9, wax gourd kernel 25, pumice stone 25, gualou kernel 22, Tinglizi 22, Baibu 9, almond 9, ginseng 3, Ophiopogon japonicus 15, Schisandra 5, Fritillaria 9, Anemarrhena 12, borneol 0.08.

The preparation method of the traditional Chinese medicine preparation capsule for treating cor pulmonale is as follows: crush each raw material through an 80-mesh sieve to obtain the traditional Chinese medicine composition powder. The obtained traditional Chinese medicine composition powder is measured according to 0.25g/grain, and processed into a capsule dosage form according to the processing and preparation method of capsules.

Example 5 The traditional Chinese medicine preparation for treating cor pulmonale is prepared from the following raw materials, all in parts by weight (10 g per part): Coix seed 30, reed rhizome 30, peach kernel 9.5, wax gourd kernel 30, sea pumice 30, gualou kernel 23, Tinglizi 26, Baibu 9.5, almond 10, ginseng 4, Ophiopogon japonicus 18, Schisandra 6, Fritillaria 9.5, Anemarrhena 13, borneol 0.12.

The preparation method of the Chinese medicinal preparation water for the treatment of cor pulmonale is:

(1) Grind coix seed, reed root, peach kernel, wax gourd kernel, pumice stone, melon seeds, Tinglizi, Baibu, almonds, ginseng, Ophiopogon japonicus, Schisandra, Fritillaria and Anemarrhena, and pass through a 130-mesh sieve. get fine powder;

(2) Mix the fine powder obtained in step (1) evenly, put it in a transparent bag, and soak it in cold boiled water at a temperature of 30°C for 7 hours, and the water consumption is 3.5 times the weight of the fine powder;

(3) Heat to boiling, and take out the transparent bag after 1.0 hour, and the obtained liquid is concentrated to 1/2-1/3 of the original volume to obtain a concentrated liquid;

(4) Grinding the borneol, adding it to the concentrated solution obtained in step (3), and aseptically packaging it to obtain the Chinese medicine composition water.

Clinical application of the traditional Chinese medicine preparation water for the treatment of cor pulmonale obtained in Example 1 of Test Example 5: From September 2009 to December 2011, 120 patients with cor pulmonale were screened in 3 secondary first-class hospitals, including 62 females and males. 58 cases, the oldest is 75 years old, the youngest is 35 years old, and the average age is 57.8 years old. 2 weeks before the test, the crowd was continuously observed, symptoms and changes were recorded, and they were randomly divided into two groups, an experimental group and a matched group. The experimental group took the product obtained in Example 5, and the matched group took other medicines (hydrochlorothiazide, metoprolol, etc.) and other conventional drugs). The method of use is: take it twice a day (warm), 350m1-500m1 each time (adjusted according to the specific situation), a course of treatment for 10 days. Criteria for judging the curative effect: cure: take this product for 3 courses of treatment, cough is significantly improved, electrocardiogram shows that coronary artery blood supply is significantly improved, discomfort symptoms disappear, energy and physical strength are significantly enhanced; effective: take this product for 3 courses of treatment, cough symptoms are relieved, electrocardiogram It showed improvement of chronic coronary artery blood supply, alleviation or partial disappearance of discomfort symptoms, increased energy and physical strength; invalid: taking this product for 3 courses of treatment, no change in discomfort symptoms. The results are shown in Table 1.

                       Table 1: The results of the treatment of people with cor pulmonale disease aged 35-75 years old who took the product of Example 5

 Treatment effect: 74 cases (74%) were cured, 25 cases (25%) were effective, 1 case (1%) was ineffective, and the total effective rate was 99%. The effect was significantly better than that of the control group.

The self-perceived symptoms and physical and mental changes during the period of taking are shown in Table 2.

Table 2:

Pulmonary heart disease is protracted and difficult to heal. The present invention uses Qianjin Reed Stem Decoction (a traditional Chinese medicine decoction composed of reed stems, coix seeds, melon petals, peach kernels, etc. Now reed roots are often used instead of reed stems, and winter melon seeds are used instead of melon petals. The clinical practice of this medicine It is commonly used in the treatment of lung abscess, lobar pneumonia, bronchitis, pertussis and other diseases) as a model, with Anemarrhena, Fritillaria, Sea Pumice, Gualou Ren to clear the lungs and reduce phlegm; Cough relief; Ginseng, Ophiopogon japonicus, and Schisandra tonify the lungs and restrain yin, nourish qi and nourish the heart; The combination of these drugs produces a synergistic effect, and can more effectively treat cor pulmonale and the sequelae caused by it. After taking it for 10 days, more than 52% of them felt better, their discomfort symptoms improved or disappeared, and their mental and physical strength increased; after taking it for 50 days, more than 75% of them felt better, their discomfort symptoms improved or disappeared, and their mental and physical strength increased; after taking 100 In one day, more than 98% of the patients felt better, their discomfort symptoms improved or disappeared, their mental and physical strength increased, and the electrocardiogram showed that the coronary blood supply was significantly improved, and some patients felt that they had recovered. In the experimental group, taking it for more than 100 days, the effective rate can reach more than 93%, while that of the control group is at most 80%.

The prescription of this application is a famous old traditional Chinese medicine prescription, and has passed the demonstration of experts and scholars of Liaocheng University and Liaocheng Hospital of Traditional Chinese Medicine, and has the prospect of industrialization implementation. The inventor of this application is an employee of Shandong University of Political Science and Law (who lectures on Invention and Creation). The completion of this invention has benefited from the support of the key discipline of the 12th Five-Year Plan of Shandong Province - Economic Law.

It should be noted that the specific implementation is only a representative example of the present invention, and obviously the technical solution of the present invention is not limited to the above-mentioned embodiments, and many variations are possible. Those of ordinary skill in the art, based on the disclosure of the present invention or obtained without objection from the written description of the document, should be considered as the protection scope of this patent.

Claims (4)

1. The traditional Chinese medicine preparation capsule for the treatment of cor pulmonale is characterized in that it is prepared from the following raw materials, all in parts by weight: coix seed 20-45, reed rhizome 20-45, peach kernel 6-12, wax gourd kernel 20-45, Sea pumice 20-45, Gualou kernel 20-26, Tinglizi 20-30, Baibu 6-12, almond 6-15, ginseng 2-6, Ophiopogon japonicus 12-25, Schisandra 3-9, Fritillaria 6 -12, Anemarrhena 10-20, borneol 0.02-0.3. 2. The traditional Chinese medicine preparation capsule as claimed in claim 1, characterized in that, 25-35% coix seed, 25-35% reed root, 9-10% peach kernel, 25-35% wax gourd kernel, 25-35% sea pumice, 22 -24, Tinglizi 22-28, Baibu 9-10, Almond 9-12, Ginseng 3-5, Ophiopogon japonicus 15-20, Schisandra 5-8, Fritillaria 9-10, Anemarrhena 12-15, Borneol 0.08-0.2 (preferably 0.1-0.15). 3. The traditional Chinese medicine capsule as claimed in claim 1, characterized in that 30 coix seeds, 30 reed roots, 9.5 peach kernels, 30 wax gourd kernels, 30 pumice stones, 23 melon seeds, 26 Tinglizi, 9.5 centipedes, Almond 10, ginseng 4, Ophiopogon japonicus 18, Schisandra 6, Fritillaria 9.5, Anemarrhena 13, borneol 0.12. 4. The preparation method of the Chinese medicine preparation capsule according to any one of claims 1-3, characterized in that, each crude drug is pulverized through a 60-100 mesh sieve (preferably 80-85 mesh sieve) to obtain a Chinese medicine preparation powder; The obtained traditional Chinese medicine preparation powder is measured according to 0.2-0.3g/grain (preferably 0.25g/grain), and processed into a capsule dosage form according to the processing and preparation method of capsules.