CN103041030B - Pharmaceutical composition for treating fever with swollen head, as well as preparation method and application thereof - Google Patents

Abstract

The invention provides a pharmaceutical composition for treating cephalopoditis, which is a preparation prepared from raw materials in the following weight proportions: 17-31 parts of Prunella vulgaris, 4-8 parts of kelp, 10-20 parts of Scutellaria baicalensis, Coptis chinensis 10-20 parts, 3-7 parts of rhubarb, 8-16 parts of Daqingye, 13-23 parts of forsythia, 17-31 parts of Radix Isatidis, 8-16 parts of puffball, 17-31 parts of Scrophulariaceae, 8- 16 parts, bellflower 4-8 parts, mint 5-11 parts, silkworm 8-16 parts, Cimicifuga 4-8 parts, Bupleurum 4-8 parts, tangerine peel 8-16 parts, licorice 8-16 parts. The invention also provides the preparation method and application of the pharmaceutical composition. The pharmaceutical composition of the invention can effectively eliminate various symptoms of the croup plague, has a good cure rate for the crocodile plague, and provides a new choice for clinical medication.

Description

A kind of pharmaceutical composition for treating croup and its preparation method and application

technical field

The invention relates to a pharmaceutical composition for treating croup and its preparation method and application.

Background technique

Datouwen is a warm-toxin disease characterized by redness, swelling and fever on the head and face caused by wind-heat evil poison. Also known as mumps, pig head fat, ear cold, big head disease, big head wind, etc., it is equivalent to epidemic mumps (viral parotitis, infectious parotitis) and suppurative parotitis (bacterial parotitis) in Western medicine. It occurs mainly in winter and spring, and is most common in children and adolescents aged 5 to 10, and it is also common in adults. It is mostly caused by the lack of righteousness in the human body and the evil poison of wind-heat. At the beginning, the evil poison lies in Weifen, and symptoms such as fever and slight aversion to cold can be seen, and then the heat poison burns the lungs and stomach, and attacks the face and throat. Although the condition of the disease is acute, most of them have no signs of crisis, and symptoms of evil entering the camp and blood and retrograde pericardium are rarely seen. The patients belonging to viral mumps in Datou plague are often classified into the category of plague because they are highly contagious. Datou plague has special clinical manifestations. In addition to the rapid onset, cold aversion and fever all over the body, the main symptom is redness, swelling and pain on the head and face. Some patients may have sore throat, followed by aversion to cold and increased heat, thirsty drinking, irritability, swelling of the head and face, and aggravated throat pain. , generally red tongue with yellow coating, rapid and rapid pulse.

Datou plague brought great pain to the patients, and the pain in the cheeks and cheeks was unbearable, which seriously affected the study and life. In some patients, the pancreas, meninges, brain, liver and heart will be damaged to varying degrees, and the serious damage to the body is not limited to the parotid gland itself, but its inevitable complications, because the virus can invade various glandular tissues or Nervous system, liver, kidney, heart, joints and almost all organs, thus often can cause meningoencephalitis, orchitis, pancreatitis, mastitis, oophoritis and other diseases. The cause of the disease is a myxovirus passing through the air After the foam spreads and invades the oral mucosa, it proliferates from the epithelial tissue and enters the blood to cause viremia, and then locates in the parotid gland or other organs, that is, the virus first invades the oral and nasal mucosa, proliferates in a large amount in the epithelial tissue, and then enters the blood circulation (the first time) Viraemia), the parotid gland and some tissues are involved in the blood flow and proliferate in it, and enter the blood circulation again (second viremia), invading some organs that were not affected last time.

In terms of treatment, there is currently no effective medicine in western medicine. It is generally recommended to use traditional Chinese medicine for treatment. It is only for suppurative parotitis caused by bacteria. Abuse issues". Traditional Chinese medicine can follow the inherently good syndrome differentiation and treatment rules of traditional Chinese medicine. According to this syndrome, the methods of clearing away heat and toxins, dispelling wind and pathogens, and reducing swelling and softening firmness are extremely good and stable, and have no toxic side effects. Therefore, there are considerable advantages in treating croupitis with traditional Chinese medicine at present.

Contents of the invention

The object of the present invention is to provide a pharmaceutical composition with good efficacy for treating croup, its preparation method and application.

The invention provides a pharmaceutical composition for treating croch fever, which is a preparation prepared from raw materials with the following weight ratio:

17-31 parts of Prunella vulgaris, 4-8 parts of kelp, 10-20 parts of skullcap, 10-20 parts of berberine, 3-7 parts of rhubarb, 8-16 parts of Daqingye, 13-23 parts of forsythia, 17-31 parts of Radix Isatidis Puffball 8-16, Scrophulariaceae 17-31, Burdock 8-16, Bellflower 4-8, Mint 5-11, Silkworm 8-16, Cimicifuga 4-8, Chai Hu 4-8 parts, tangerine peel 8-16 parts, licorice 8-16 parts.

Further, it is a preparation prepared from raw materials with the following weight ratio:

22-26 parts of Prunella vulgaris, 5-7 parts of kelp, 13-17 parts of skullcap, 13-17 parts of berberine, 4-6 parts of rhubarb, 10-14 parts of Daqingye, 16-20 parts of forsythia, 22-26 parts of Radix Radix 10-14 parts of Puffball, 22-26 parts of Scrophulariaceae, 10-14 parts of Arctium, 5-7 parts of Campanulaceae, 7-9 parts of Mint, 10-14 parts of Silkworm, 5-7 parts of Cimicifuga, Chai Hu 5-7 parts, tangerine peel 10-14 parts, licorice 10-14 parts.

Further preferably, it is a preparation prepared from raw materials in the following weight ratio:

24 parts of Prunella vulgaris, 6 parts of kelp, 15 parts of skullcap, 15 parts of coptis, 5 parts of rhubarb, 12 parts of Daqingye, 18 parts of forsythia, 24 parts of Radix Isatidis, 12 parts of puffball, 24 parts of scrophulariaceae, 12 parts of burdock , 6 parts of bellflower, 8 parts of mint, 12 parts of silkworm, 6 parts of Cimicifuga, 6 parts of Bupleurum, 12 parts of tangerine peel, and 12 parts of licorice.

Wherein, the pharmaceutical composition is a preparation prepared from the water or organic solvent extract of the bulk drug in the weight ratio as the active ingredient, plus commonly used pharmaceutical excipients or auxiliary ingredients.

Wherein, the preparation is an oral administration preparation.

Further, the oral administration preparation is granule, powder, pill, drop pill, capsule, soft capsule, tablet or oral liquid.

The present invention also provides a preparation method of the above-mentioned pharmaceutical composition, which comprises the following steps:

(1) Weigh the raw material drug according to the weight ratio;

(2) Add water and first decoct all the other medicines except mint and rhubarb, then add mint and rhubarb, combine the decoction, concentrate, add pharmaceutically available auxiliary materials or auxiliary ingredients to prepare conventional preparations.

The present invention also provides the use of the above pharmaceutical composition in the preparation of medicine for treating croup.

Wherein, the medicament is a medicament for treating croup or its complications caused by wind-warm evil poison, heat and fire, blocking Shaoyang and Yangming meridians, stagnation that does not dissipate, and attacking cheeks and cheeks.

Wherein, the medicine is a medicine for treating mumps or suppurative parotitis.

At present, it has been recognized that "holistic concept", "treatment based on syndrome differentiation", "compound use", and "combination of compound medicines is like using soldiers" are the most scientific and effective advantages of traditional Chinese medicine. Original theory of medicine. The interlocking and tight compatibility of the various medicines in the prescription of traditional Chinese medicine is an effective means that it is superior to the formula of western medicine. The theory of traditional Chinese medicine prescriptions believes that each prescription not only needs to be properly compatible with the appropriate drugs according to the etiology and pathogenesis, but also should conform to the basic structure of the prescription, that is, the theory of prescription compatibility of "lord, minister, assistant, and envoy", the so-called " The prescription compatibility of "jun, minister, assistant, and envoy" is a scientific ratio based on an all-round judgment of the pathogenesis of the disease. Traditional Chinese medicine uses a multi-link, multi-target integrated biological mechanism to regulate Datouwen, a disease that suffers from wind, temperature, evil poison and flaming heat toxin, and can achieve better, longer-lasting, greener, natural and non-toxic treatments than western medicine. The therapeutic effect of toxic and side effects, and this curative effect is based on the correct guidance of the above-mentioned traditional Chinese medicine original theory, and the present invention has just followed this principle.

In the traditional theory of Chinese medicine, the big head plague is due to the feeling of wind, temperature and evil poison, the heat turns into fire, blocks the Shaoyang and Yangming meridians, the stagnation does not dissipate, and attacks the cheeks and cheeks, resulting in local swelling, pain, or even high fever Symptoms such as non-regression, irritability, headache, and difficulty in chewing. Therefore, according to the original theory and rules of TCM syndrome differentiation and treatment, the present invention uses the methods of clearing away heat and toxins, dispelling wind and pathogens, reducing swelling and softening hardness, and the prescription is as the prescription of the pharmaceutical composition of the present invention. In the prescription, Banlangen, which is good at clearing away heat and detoxifying and can inhibit the virus, is used as the monarch medicine. It is combined with the medicines of Folium Folium and Forsythia in the left hall to clear away heat and detoxify, Scutellaria baicalensis, Coptis chinensis, and rhubarb to cleanse heat and poison; Cimicifuga and Bupleurum dispel wind and disperse evil. The above-mentioned left and right palace minister medicines and auxiliary monarch medicines are intended to eliminate the main cause of the disease. The adjuvant medicines are divided into three ways: the left side adjuvant platycodon root, burdock seed, and tangerine peel to relieve lung qi, and licorice to benefit the throat; the right side adjuvant medicine puffy root and scrophulariae are not only good at clearing away heat and detoxification, but also good at relieving throat, dissipating stagnation and reducing swelling ; and the adjuvant medicine in the middle road is Prunella vulgaris, which is good at clearing Shaoyang, reducing fire and dispelling stagnation, and kelp, which is soft and firm, to solve the problem of cheek swelling and pain. The medicinal licorice, in addition to clearing, relieving spasms, relieving pain, and nourishing righteousness, can also harmonize various medicines. The above groups of medicinal flavors have distinct roles and complement each other, giving full play to the essence of speculative scientific research methodology unique to traditional Chinese medicine, such as the formation of an army. Therefore, good curative effects can be obtained.

The pharmaceutical composition of the invention can effectively eliminate various symptoms of the croup plague, has a good cure rate for the crocodile plague, and provides a new choice for clinical medication.

Detailed ways

The preparation of embodiment 1 pharmaceutical composition of the present invention

Take 24 grams of Prunella vulgaris, 6 grams of kelp, 15 grams of skullcap, 15 grams of berberine, 5 grams of rhubarb, 12 grams of Daqingye, 18 grams of forsythia, 24 grams of Radix Isatidis, 12 grams of puffballs, 24 grams of scrophulariaceae, and 12 grams of burdock. gram, bellflower 6 grams, mint 8 grams, silkworm 12 grams, Cimicifuga 6 grams, Bupleurum 6 grams, dried tangerine peel 12 grams, licorice 12 grams. Weigh each medicinal herb according to its quantity, and wrap mint and rhubarb in a single or double layer of clean gauze for later use. Mix with a sufficient amount of clean water, first decoct the other herbs except mint and rhubarb, then boil and fry for 15 to 20 minutes, then add mint and rhubarb, and boil for 8 to 10 minutes, then collect the water decoction; the dregs are decocted twice with water, and the decoctions are combined to obtain a decoction.

The preparation of embodiment 2 pharmaceutical composition of the present invention

Take 31 grams of Prunella vulgaris, 4 grams of kelp, 10 grams of skullcap, 10 grams of berberine, 3 grams of rhubarb, 8 grams of Daqingye, 13 grams of forsythia, 17 grams of Radix Isatidis, 8 grams of puffballs, 17 grams of scrophulariaceae, and 8 grams of burdock. 4 grams of bellflower, 5 grams of mint, 8 grams of silkworm, 4 grams of Cimicifuga, 4 grams of Bupleurum, 8 grams of tangerine peel, and 8 grams of licorice. Prepare decoction according to the method of Example 1, after concentration, add appropriate amount of starch and dextrin and mix evenly before granulating.

The preparation of embodiment 3 pharmaceutical composition of the present invention

Take 17 grams of Prunella vulgaris, 8 grams of kelp, 20 grams of skullcap, 20 grams of berberine, 7 grams of rhubarb, 16 grams of Daqingye, 23 grams of forsythia, 31 grams of isatidis, 16 grams of puffballs, 31 grams of scrophulariaceae, and 16 grams of burdock. 8 grams, bellflower 8 grams, mint 11 grams, silkworm 16 grams, Cimicifuga 8 grams, Bupleurum 8 grams, tangerine peel 16 grams, licorice 16 grams. The decoction was prepared according to the method of Example 1, concentrated, dried, added appropriate amount of dextrin and soluble starch to granulate, and compressed into tablets to obtain tablets.

Embodiment 4 Preparation of the pharmaceutical composition of the present invention

Take 22 grams of Prunella vulgaris, 7 grams of kelp, 17 grams of skullcap, 17 grams of berberine, 6 grams of rhubarb, 14 grams of Daqingye, 20 grams of forsythia, 26 grams of Radix Isatidis, 14 grams of puffballs, 26 grams of scrophulariaceae, and 14 grams of burdock. gram, bellflower 7 grams, mint 9 grams, silkworm 14 grams, Cimicifuga 7 grams, Bupleurum 7 grams, orange peel 14 grams, licorice 14 grams. Prepare the decoction according to the method of Example 1, combine the filtrates, concentrate and dry, add an appropriate amount of microcrystalline cellulose, mix well, and pack into capsules to obtain capsules.

Embodiment 5 Preparation of the pharmaceutical composition of the present invention

Take 26 grams of Prunella vulgaris, 5 grams of kelp, 13 grams of skullcap, 13 grams of berberine, 4 grams of rhubarb, 10 grams of Daqingye, 16 grams of forsythia, 22 grams of Radix Isatidis, 10 grams of puffballs, 22 grams of scrophulariaceae, and 10 grams of burdock. 5 grams of bellflower, 7 grams of mint, 10 grams of silkworm, 5 grams of Cimicifuga, 5 grams of Bupleurum, 10 grams of tangerine peel, and 10 grams of licorice. First extract with 70% v/v ethanol, combine the ethanol extract, recover the ethanol, and use the obtained alcohol extract for later use; decoct the dregs with water for 2 times, combine the water decoction, concentrate, and use the obtained water extract for later use; Combine the alcohol extraction extract and the water extraction extract, dry, crush, pass through an 80-mesh sieve, and mix the ingredients evenly for later use;

Take an appropriate amount of polyethylene glycol 4000, after melting, add the above-mentioned uniformly mixed drug into the molten matrix, keep it warm at 75-85°C; use a dropping pill machine, drop it into simethicone oil, collect the dropping pills, and get Pills.

The beneficial effects of the present invention will be specifically described below through test examples.

Clinical (outpatient) treatment situation of test example 1 pharmaceutical composition of the present invention

(1) Situation of admitted patients

Age and gender range of patients: mainly children and adolescents, but also adults, male and female, with the following symptoms and characteristics (partial, not necessary and impossible to have all of them), a total of 21 cases were treated.

Symptom characteristics:

Generally: In addition to the acute onset, body aversion to cold and fever, the main symptoms are redness, swelling and pain on the head and face. Some patients may have sore throat, followed by aversion to cold and increased heat, thirsty drinking, irritability, swelling of the head and face, and aggravated sore throat, but seldom occurs the syndrome of trapped blood. On the tongue pulse, the tongue is generally red and yellow, and the pulse is fast and fast. In short, swelling and pain under the ears are the earliest symptoms. A small number of patients have fever (body temperature can reach 39-40°C), headache, vomiting, loss of appetite and other systemic discomfort symptoms 1 to 2 days before the parotid gland enlargement, and then develop symptoms. Pain under one or both ears, swollen parotid gland, tense, shiny, not red, hot, and obvious pain on the surface skin, aggravated when opening mouth or eating sour food. Usually, one side of the parotid gland is enlarged first, and then develops to both sides, but it can also be seen that both parotid glands are enlarged at the same time. On the buccal mucosa next to the maxillary second molars, a swollen orifice of the parotid gland can be seen without purulent discharge.

Or: moderately elevated body temperature, headache, muscle soreness, etc., but parotid gland swelling is still the first sign, which lasts for about 7 to 10 days. Often, one side of the parotid gland swells first, and the opposite parotid gland also swells after 2 to 3 days Large, sometimes swollen only on one side. The characteristic of parotid gland enlargement is that the earlobe is the center, expanding forward, backward, and downward, with unclear edges, elastic feeling to touch, pain and tenderness, surface skin is not red, can be There is a sense of heat, and the pain intensifies when opening the mouth and chewing, especially when eating acidic food, and the mouth of the parotid duct is often red and swollen. Swelling and pain peaked at 3 to 5 days, ipsilateral pharynx and soft palate may be swollen, tonsils shifted to the midline, laryngeal edema may also occur, edema may also occur in the chest, and red maculopapules or urticaria may occasionally be seen on the trunk.

Or: In some patients, the pancreas, meninges, brain, liver and heart will be damaged to varying degrees, and the serious harm to the body is not limited to the parotid gland itself, but because the virus can invade various glandular tissues or nervous system and liver. , kidney, heart, joints and almost all organs and lead to complications, the common ones are meningoencephalitis, orchitis, oophoritis, pancreatitis, mastitis and so on.

The above-mentioned symptoms and patients are usually caused by the lack of righteousness and the evil poison of wind and temperature, the heat turns into fire, blocks the Shaoyang and Yangming meridians, the stagnation does not dissipate, and it is caused by attacking the cheeks.

(2) Standards of treatment

Recovery: the above-mentioned symptoms and characteristics completely disappeared, and no abnormalities in relevant indicators were found in the examination.

Significant curative effect: the above symptoms were significantly relieved, and the test indicators were improved to a considerable extent.

There is a certain effect: the patient's symptoms are alleviated, or the indicators are slightly improved.

Invalid: Symptoms remain, indicators have not improved.

(3) Treatment methods

1. The decoction prepared in Example 1, take 200 to 400ml each time, or 1 bowl of rice bowl used for daily meals (the dosage for children is reduced according to the age, and the dosage is reduced according to the aforementioned method, but the number of daily doses needs to be increased accordingly), Take it every 3 hours to 4 hours on the first day, and take it every 4 hours to 6 hours from the next day, taking it on time and according to the amount.

2. Pay attention to and scientifically regulate daily life, and observe some necessary precautions, such as:

⑴ For infectious mumps in croup, first of all, we should pay attention to prevention and eradication of infection: do not participate in large-scale group activities during the epidemic period, and try to avoid going to crowded places; patients should be isolated from healthy people, and should be isolated until the swelling of the parotid gland completely subsides The patient’s eating utensils should be separated from those of other people, and should be boiled and disinfected regularly; their clothes, bedding and other items can be exposed to the sun outdoors; washbasins, towels, handkerchiefs and other items , It needs to be scalded with boiling water 1 to 2 times a day.

(2) Adjust diet: due to enlarged parotid glands, it is difficult to eat, so eat nutritious, easy-to-digest semi-liquid food or soft food, such as porridge, noodle soup, egg custard, etc. Do not eat hot and sour, sweet and dry foods (especially acidic foods), so as not to stimulate the secretion of salivary glands and aggravate the swelling and pain of the parotid glands. Properly add more water to facilitate the discharge of toxins from the body. Do not drink alcohol, smoke (especially for adult patients), do not eat spicy fried food, fat and sweet food, and beef, mutton and dog meat that "generate heat and phlegm" and eat more fresh, light and nutritious food.

(3) Pay attention to adequate rest and live a regular life.

⑷ The residence needs air circulation, and regular ventilation is required to keep the air fresh.

(5) Pay attention to hygiene: pay attention to oral hygiene, and often gargle with warm salt water or compound borax solution to remove food residues in the oral cavity and prevent secondary bacterial infection. At home, 0.2% peracetic acid can be used for disinfection.

⑹Using a hot water bottle wrapped with a clean towel to heat the affected area can help relieve pain in the affected area.

(7) Measure body temperature regularly, and if necessary (over 39°C), use physical methods such as cold compresses on the head, bathing with warm water or alcohol to assist in cooling down.

(8) Closely observe whether there are complications. For example, if the patient has acute high fever with severe headache, vomiting, lethargy, or disturbance of consciousness, and positive meningeal irritation signs, etc., he should be vigilant for meningitis or meningoencephalitis, and should seek medical examination and treatment in time. The mumps virus is good at invading mature reproductive glands, so the risk will increase in patients after 13 to 14 years old, in late adolescence, and in adults. Orchitis usually occurs about a week after cheek swelling, usually with sudden high fever, chills, testicular swelling and pain, accompanied by severe tenderness. In severe cases, the skin of the scrotum is obviously edematous, and there is yellow fluid in the sheath cavity. Most of the lesions only invade one side . If a male patient finds testicular pain, use a clean bandage or a T-shaped cloth to support the scrotum to relieve pain; if testicular swelling is accompanied by tenderness, use a clean towel soaked in cold water to apply cold compresses to the area, and then place the testicular Hold up to improve local symptoms. Ovariitis complicated by female patients generally has mild symptoms and does not affect pregnancy. The main manifestations are sudden onset of chills, fever, pain in the lower abdomen or lumbosacral region, increased vaginal secretions, and menstrual cycle disorders. Ovary, with tenderness.

(4) Treatment results

Twenty-one cases (mostly children and adolescents) of this disease have been treated with the pharmaceutical composition of the present invention, and good curative effects have been obtained. The treatment time varies slightly according to the specific conditions of each patient, such as the severity, age, physical strength, etc. Generally, the symptoms can be significantly relieved in about 2 to 4 days, and the various symptoms can be relieved in about 10 to 15 days. Then it can be completely eliminated. According to the above-mentioned scientific regulation of daily life, and following the precautions, it can be completely cured with few complications.

According to the aforementioned treatment standards, all 21 patients were cured, with a cure rate of 100%, and the effect was good.

Typical cases

The patient, female, 11 years old, student, felt dizzy, painful, nauseated, and unwell, and her body temperature was 38.5°C. The next day, the child felt swelling under the left ear and felt pain. Observe that the cheeks and cheeks of the patient are swollen, the edges are unclear, the skin is shiny, hot but not red, and it is elastic and tense to the touch. He reported pain under the ear, worse when opening his mouth and eating, aversion to cold, upset, sore throat, thirst, no appetite, yellow rotting, body temperature 39°C, pulse examination, few and real slight strings, red tongue with thin yellow coating , for big head plague. Administer the pharmaceutical composition of the present invention (prepared in Example 1), and strictly follow the medication method in "1" of the above "treatment method" and the scientific conditioning and precautions in "2". After the child took the medicine for 2 days, the pain was obviously relieved, and other symptoms were also alleviated to some extent. The tongue was still red, but the yellow coating was less, and the pulse was solid and rapid. Advise it to continue to take, conditioning as before. The pain and symptoms were gradually relieved. One week later, he only took the medicine twice a day. By about two weeks, the swelling and pain were all gone, and all other symptoms had disappeared without any complications. No abnormal indicators were found in the physical examination afterward, and there was no recurrence in follow-up.

summary:

(1) The pharmaceutical composition of the present invention can effectively eliminate local diffuse swelling, pain, or even pain caused by feeling wind, temperature, evil poison, heat and even fire, blocking the Shaoyang and Yangming meridians, stagnation but not dissipating, and attacking the cheeks and cheeks. Persistent high fever, irritability and headache, big head plague with difficulty chewing and similar TCM syndromes and symptoms.

(2) The inventor has used the pharmaceutical composition of the present invention and the original prescription of Puji Xiaoxiaoyin to treat the disease for decades, and found that the effect of the pharmaceutical composition of the present invention is significantly better than that of the original prescription of Puji Xiaoxiaoyin, mainly in the following aspects:

①In the same treatment period, 100% of the patients can be cured by using the pharmaceutical composition of the present invention, while about 10% of the patients can not be cured by using the original Puji Xiaodu Decoction.

② After administration to patients with similar constitutions, it was found that the treatment time of the original formula of Puji Xiaoduyin was 5-7 days longer than that of the pharmaceutical composition of the present invention, which indicated that the healing time of the pharmaceutical composition of the present invention was shorter.

To sum up, the pharmaceutical composition of the present invention can effectively eliminate various symptoms of croch fever, has a good cure rate for crocodile fever, and provides a new option for clinical medication.

Claims (9)

1. A pharmaceutical composition for the treatment of croup, characterized in that: it is a preparation prepared from the crude drug of the following weight ratio: 24 parts of Prunella vulgaris, 6 parts of kelp, 15 parts of skullcap, 15 parts of coptis, 5 parts of rhubarb, 12 parts of Daqingye, 18 parts of forsythia, 24 parts of Radix Isatidis, 12 parts of puffball, 24 parts of scrophulariaceae, 12 parts of burdock , 6 parts of bellflower, 8 parts of mint, 12 parts of silkworm, 6 parts of Cimicifuga, 6 parts of Bupleurum, 12 parts of tangerine peel, and 12 parts of licorice. 2. The pharmaceutical composition according to claim 1, characterized in that: the pharmaceutical composition is an active ingredient by water or organic solvent extract of the crude drug of the weight ratio, plus pharmaceutically commonly used adjuvant Prepared preparations. 3. The pharmaceutical composition according to claim 1 or 2, characterized in that: the preparation is an oral administration preparation. 4. The pharmaceutical composition according to claim 3, characterized in that: the oral administration preparation is granule, powder, pill, capsule, tablet or oral liquid. 5. The pharmaceutical composition according to claim 3, characterized in that: the oral administration preparation is a dropping pill or a soft capsule. 6. The preparation method of the pharmaceutical composition according to any one of claims 1 to 5, characterized in that: it comprises the following steps: (1) Weigh the raw material drug according to the weight ratio; (2) Add water and first decoct the other medicines except mint and rhubarb, then add mint and rhubarb, combine the decoction, concentrate, add pharmaceutically available auxiliary materials to prepare a conventional preparation. 7. Use of the pharmaceutical composition according to any one of claims 1 to 5 in the preparation of a medicament for treating croup. 8. The use according to claim 7, characterized in that: said medicine is used to treat diseases caused by wind, temperature, evil poison, heat and even fire, restraining Shaoyang, Yangming meridian, stagnation but not dissipating, and attacking cheeks and cheeks. Drugs caused by croup. 9. The use according to claim 7, characterized in that: the medicine is a medicine for treating mumps or suppurative parotitis.