CN1030186A - Developer for ultrasonic examination and method for making thereof - Google Patents
Developer for ultrasonic examination and method for making thereof Download PDFInfo
- Publication number
- CN1030186A CN1030186A CN 88102791 CN88102791A CN1030186A CN 1030186 A CN1030186 A CN 1030186A CN 88102791 CN88102791 CN 88102791 CN 88102791 A CN88102791 A CN 88102791A CN 1030186 A CN1030186 A CN 1030186A
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- Prior art keywords
- agent
- ultrasonic examination
- making
- ultrasonic
- organism
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- 238000000034 method Methods 0.000 title claims abstract description 18
- 210000000056 organ Anatomy 0.000 claims abstract description 20
- 210000002784 stomach Anatomy 0.000 claims abstract description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 9
- 201000010099 disease Diseases 0.000 claims abstract description 8
- 239000008187 granular material Substances 0.000 claims abstract description 8
- 230000005070 ripening Effects 0.000 claims abstract description 8
- 230000004304 visual acuity Effects 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 7
- 238000012216 screening Methods 0.000 claims abstract description 7
- 239000000523 sample Substances 0.000 claims abstract description 6
- 239000010985 leather Substances 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 4
- 238000012856 packing Methods 0.000 claims abstract description 4
- 238000000053 physical method Methods 0.000 claims abstract description 4
- 238000002604 ultrasonography Methods 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims abstract description 3
- 244000068988 Glycine max Species 0.000 claims abstract 2
- 235000010469 Glycine max Nutrition 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims description 29
- 239000004615 ingredient Substances 0.000 claims description 17
- 239000010977 jade Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 6
- 229920001817 Agar Polymers 0.000 claims description 5
- 240000007594 Oryza sativa Species 0.000 claims description 5
- 235000007164 Oryza sativa Nutrition 0.000 claims description 5
- 244000046052 Phaseolus vulgaris Species 0.000 claims description 5
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
- 239000008272 agar Substances 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 235000009566 rice Nutrition 0.000 claims description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 238000007689 inspection Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 208000010643 digestive system disease Diseases 0.000 claims description 3
- 208000018685 gastrointestinal system disease Diseases 0.000 claims description 3
- 230000000680 avirulence Effects 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 238000004080 punching Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims 3
- 239000013049 sediment Substances 0.000 claims 2
- 235000011202 Angiopteris lygodiifolia Nutrition 0.000 claims 1
- 241000723185 Cyathea Species 0.000 claims 1
- 210000001557 animal structure Anatomy 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 abstract description 8
- 230000002093 peripheral effect Effects 0.000 abstract description 6
- 238000003745 diagnosis Methods 0.000 description 8
- 230000003902 lesion Effects 0.000 description 6
- 210000000936 intestine Anatomy 0.000 description 4
- 239000003643 water by type Substances 0.000 description 3
- 208000018522 Gastrointestinal disease Diseases 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 201000011591 microinvasive gastric cancer Diseases 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 208000018556 stomach disease Diseases 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention provides a kind of stomach window-85 developer for ultrasonic examination and method for making that medical ultrasonic is checked human body (containing other organism) gastrointestinal, pipe peripheral organ and shallow meter organ disease that be used for.This photographic developer is by to the screening of edible material from soybeans and the adjustment of proportion relation, makes the ripening granule through physical method, mixes under drying regime or liquid state with a certain proportion of suspending-aid material again.This photographic developer oral administration, coloclysis and filling stomach enter in the body or the leather bag pocket facing of packing into carries out ultrasonic examination in external, can make medium interface form best acoustic impedance difference, reduce ultrasonic pseudo-shadow and interference, the basic resolving power of Ultrasound Instrument probe and the actual resolving power gap in using are significantly dwindled.
Description
The present invention relates to be used for stomach window-85 developer for ultrasonic examination and method for making thereof that human intestines and stomach, pipe peripheral organ and superficial organ (comprising organism) medical ultrasonic is checked, particularly can make ultrasonic interface obtain the optimum sound impedance contrast, significantly improve the acoustic image quality, enlarge the developer for ultrasonic examination and the method for making thereof of diagnostic area.
At present, human intestines and stomach's inspection means that medical domain is commonly used are lonizing radiation radiography and splanchnoscopy, its deficiency is, can not show gastrointestinal wall hierarchical structure and part gastrointestinal week adjacent organ and the internal structure and the distribution situation of above-mentioned organ lesion, and human body had certain traumatic.For remedying above deficiency, domestic from 84 years abroad from 76 years, some experts and scholars begin one's study and use the method for B ultrasonic diagnosis gastrointestinal disease.Mainly contain the full development of water, Chinese medicine development.Said method makes ultrasonic examination human stomach disease obtain certain progress, can diagnose the apparent in view eminence lesion of stomach, but can not clearly seize the small lesion of early gastric cancer and other character of stomach, to pathological changes etiologic diagnosis difficulty, the demonstration of adjacent organ is restricted to intestinal and some stomaches week, does not widen and improves the ultrasonic diagnosis scope of human body superficial organ or other organism organ and be worth or the like.Trace it to its cause is that said method fails to break through formed pseudo-shadow and this technical barrier of interference in the minimizing ultrasonic examination, make the basic resolving power and the resolving power gap great disparity that is applied in the actual inspection of existing Ultrasound Instrument probe, so limited the quality and the scope of ultrasonic examination diagnosis.Use developer for ultrasonic examination formulation selection, proportion relation and the preparing process of mechanism design of the present invention, be blank in the past.
The objective of the invention is to provide a kind of simple and easy to do method, make and have the ultrasonic pseudo-shadow of minimizing and interferential photographic developer, be used for ultrasonic examination, it not only can not have wound, has no side effect, diagnoses expeditiously human body (containing other organism) gastrointestinal, pipe peripheral organ and superficial organ's multiple disease, and can significantly improve the acoustic image quality, show tiny focus, widen the ultrasonic examination diagnostic area, especially provide a kind of desirable means for generaI investigation human body early gastric cancer, early stage cancer of pancreas, breast carcinoma of early stage etc.
Invention is achieved in that by the screening of the harmless multiple eating material of organism and the adjustment of proportion relation are obtained raw material side, make the ripening granule through physical method, again with a certain proportion of gummy class and cellulose derivative in any suspending-aid material under drying regime or liquid state, mix, make dry suspensoid (face time spent add water make suspension) and liquid type suspension respectively, promptly be called stomach window-85 developer for ultrasonic examination by special ratios.This agent oral administration, coloclysis and filling stomach enter organism gastrointestinal portion or the leather bag pocket facing of packing into need be examined the position in organism, use ultrasonic routine examination, being examined position acoustic image can form similar human liver and organize sample echo, make medium interface form best acoustic impedance difference, ultrasonic pseudo-shadow and interference such as artifact that the high low attenuation range of reverberation effect, medium that produces in elimination or the minimizing ultrasonic examination causes and imaging distortion distortion, thus the basic resolving power of Ultrasound Instrument probe and the actual resolving power gap in using are significantly dwindled.So, can not only clear demonstration complete, abundant human intestines and stomach's disease acoustic image feature, make etiologic diagnosis, and can seize and differentiate gastrointestinal wall small lesion less than 5 millimeters, and the inspection that is suitable for pipe peripheral organ and superficial organ's small lesion is diagnosed, and be applied to other organism, the particularly ultrasonic examination of vertebrates homologous organs disease except that human body.The use of product of the present invention is unrestricted, and old children is all suitable.
Composition of raw materials of the present invention source is wide, and to organism avirulence and side effect, technology is simple for production, and dosage form is stable, so be beneficial to enforcement; Simultaneously because mechanism of the present invention design is not to be conceived to reduce the ultrasonic interference that flatuosity and mucus cause merely, but comprise elimination or reduce formed pseudo-shadow and interference in the ultrasonic examination, so, not only significantly improve ultrasonic display quality, can be clear, the various acoustic image features that show gastrointestinal disease realistically, seize small lesion of different nature, and, enlarged the ultrasonic examination diagnostic area, comprise the human intestines and stomach, the pipe peripheral organ, ophthalmology, mammary gland, thyroid and other shallow meter organ disease's ultrasonic examination diagnosis also is applicable to the ultrasonic examination diagnosis at other similar position of organism; In addition because can be clear, show the gastrointestinal wall hierarchical structure realistically, so to the diagnosis of gastrointestinal wall inner disease foci and the resolution of discriminating and peripheral reference, easier acquisition accurate result.
Embodiments of the invention comprise: 1, make major ingredient; 2, preparing ingredients; 3, with major ingredient and batching preparation by a certain percentage.
1, major ingredient total umber of getting any of rice and beans in the edible thing of vegetalitas or forming by arbitrary proportion by any rice and any beans in the edible thing, through ripening, oven dry and crushing screening, obtain the dried granule of ripening of maximum diameter≤0.6 millimeter.
2, batching has three kinds: the one, and through crushing screening, the dried starch of granule maximum diameter≤0.6 millimeter; The 2nd, per 100 ml waters contain the sodium carboxymethyl cellulose suspension of sodium carboxymethyl cellulose 0.5-2 gram; The 3rd, per 100 ml waters contain the agar solution of agar 0.5-5 gram.
3, major ingredient is mixed stirring by a certain percentage with three kinds of batchings respectively, the pure loop ∪ purport row of covering with mat steal how to answer 85 developer for ultrasonic examination, are named shallow lake agent, carboxylic agent and fine jade agent.(1) shallow lake agent: the mixed by major ingredient 1-8.3 gram, dried starch 0.17-1.33 gram stirs, and makes the shallow lake agent.According to ultrasonic examination required dosage standard, the proportion that contains the shallow lake agent of 3.5-29 gram by per 100 ml waters takes by weighing the shallow lake agent and packs, and can add an amount of white sugar, flavoring agent.Add the drenched shallow lake agent of an amount of cold boiled water during use earlier, the boiling water punching out of reuse respective amount stirs evenly, and per 100 milliliters of its total amount should contain shallow lake agent 3.5-29 gram, can be oral, coloclysis and filling stomach or the leather bag bag of packing into carry out the ultrasonic examination of human body and other organism.(2) carboxylic agent and fine jade agent:, take by weighing major ingredient with per 100 milliliters of proportions that contain major ingredient 3-25 gram of 0.5-2% sodium carboxymethyl cellulose suspension or 0.5-5% agar solution according to ultrasonic examination required dosage standard.First during preparation with the drenched major ingredient of an amount of distilled water, sodium carboxymethyl cellulose suspension with respective amount 0.5-2% is mixed into the carboxylic agent again, or being mixed into the fine jade agent at a certain temperature with the agar solution of respective amount 0.5-5%, per 100 milliliters of carboxylic agent or fine jade agent should contain major ingredient 3-25 gram respectively.Can add an amount of white sugar, flavoring agent and antiseptic, carboxylic agent and fine jade agent be packed with bottle respectively by the various dose standard again, the ultrasonic examination to human body or other organism can be provided, the time spent shakes up, and can heat.
Above method for making must meet the health legislation standard.Ultrasonic examination uses the dosage standard of stomach window-85 developer for ultrasonic examination to be: it is for oral use to be grown up: each 600-800 milliliter, and children's is cut down according to the circumstance; Adult's coloclysis is used: each 800-1200 milliliter, and children's is cut down according to the circumstance; The leather bag bag is used: the 300-600 milliliter; Part human body superficial organ and other organism organ ultrasonic examination dosage standard; According to circumstances select any amount.
Claims (12)
1, a kind of medical ultrasonic that is used for is checked the organism organ disease, method for making especially for stomach window-85 developer for ultrasonic examination of checking the human body gastroenteropathy, raw material side is by the edible material from soybeans by screening and adjustment proportion relation, make the dried granule of ripening through physical method, under drying regime or liquid state, be mixed and made into shallow lake agent, carboxylic agent and fine jade agent with a certain proportion of suspending-aid material again and form, it is characterized in that:
A, described raw material side are total umbers of any or both proportionings of edible thing rice, beans,
B, the agent of described shallow lake, carboxylic agent and fine jade agent are by making major ingredient, preparing ingredients, the major ingredient and the mixed preparing of preparing burden are by a certain percentage finished,
C, described physical method make the dried granule of ripening be raw material side behind ripening, oven dry and crushing screening, obtain the dried granule of ripening of maximum diameter≤0.6 millimeter,
D, described a certain proportion of suspending-aid material are any of a certain proportion of gummy class and cellulose derivative.
2, method for making according to claim 1 is characterized in that making major ingredient and gets any rice and the total umber of any beans by the arbitrary proportion composition in any or edible thing of rice and beans in the edible thing.
3, according to claim 1,2 described method for makings, the proportion mixing and stirring that restrains by major ingredient 1-8.3 gram, dried starch 0.17-1.33 is made in the agent that it is characterized in that forming sediment.
4,, it is characterized in that the per 100 milliliter proportion mixing and stirring that contain major ingredient 3-25 gram of carboxylic agent making by 0.5-2% sodium carboxymethyl cellulose suspension according to claim 1,2 described method for makings.
5,, it is characterized in that the per 100 milliliter proportion mixing and stirring that contain major ingredient 3-25 gram of fine jade agent making by the 0.5-5% agar solution according to claim 1,2 described method for makings.
6, according to claim 1,2,3 described method for makings, drenched with cold boiled water earlier when the agent that it is characterized in that forming sediment is used, the punching out of reuse boiling water stirs evenly, and per 100 milliliters of its total amount should contain shallow lake agent 3.5-29 gram.
7,, it is characterized in that through crushing screening the dried starch of granule maximum diameter≤0.6 millimeter according to the method for making of claim 3.
8, a kind of stomach window-85 developer for ultrasonic examination product that is used for medical ultrasonic inspection organism organ disease, it is characterized in that but oral administration, coloclysis and filling stomach enter organism or the leather bag pocket facing of packing into need be examined the position in organism and carries out ultrasonic examination respectively, can make and be examined position acoustic image and form similar human liver and organize sample echo, make medium interface form best acoustic impedance difference, thereby reduce ultrasonic pseudo-shadow and interference, can be used for ultrasonic examination animal organ's disease.
9, product according to claim 1 is characterized in that being used for organism and refers to a clear a unit of weight used in ancient China, equal to six liang except that the human body an ancient measure spinulose tree fern that makes internal disorder or usurp
10,, it is characterized in that eliminating and reduce artifact that the high low attenuation range of reverberation effect, medium in the ultrasonic examination causes and pseudo-shadow and the interference due to the imaging distortion distortion according to claim 1,2 described products.
11,, it is characterized in that making the basic resolving power of Ultrasound Instrument probe and the actual resolving power gap in using to dwindle according to claim 1,2 described products.
12, according to claim 1,2 described products, it is characterized in that avirulence and side effect, can be used for the ultrasonic examination of all kinds of organisms without restriction, old children is all suitable.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88102791 CN1024628C (en) | 1988-04-26 | 1988-04-26 | Ultrasonic developer containing plant food and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88102791 CN1024628C (en) | 1988-04-26 | 1988-04-26 | Ultrasonic developer containing plant food and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1030186A true CN1030186A (en) | 1989-01-11 |
| CN1024628C CN1024628C (en) | 1994-05-25 |
Family
ID=4832305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 88102791 Expired - Lifetime CN1024628C (en) | 1988-04-26 | 1988-04-26 | Ultrasonic developer containing plant food and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1024628C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420176A (en) * | 1990-06-01 | 1995-05-30 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| US5948387A (en) * | 1990-06-01 | 1999-09-07 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| CN110478500A (en) * | 2019-08-19 | 2019-11-22 | 吉林省恒光医疗科技有限公司 | A kind of radiography agent prescription and preparation method thereof for ultrasound diagnosis |
| CN115400230A (en) * | 2022-09-03 | 2022-11-29 | 福建医科大学附属协和医院 | Novel multifunctional gastrointestinal ultrasonic contrast agent |
| CN119236122A (en) * | 2024-12-09 | 2025-01-03 | 北京大学第三医院（北京大学第三临床医学院） | Liquid gastrointestinal ultrasound examination reagent and preparation method thereof |
-
1988
- 1988-04-26 CN CN 88102791 patent/CN1024628C/en not_active Expired - Lifetime
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420176A (en) * | 1990-06-01 | 1995-05-30 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| US5639442A (en) * | 1990-06-01 | 1997-06-17 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| US5714528A (en) * | 1990-06-01 | 1998-02-03 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| US5714529A (en) * | 1990-06-01 | 1998-02-03 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| US5948387A (en) * | 1990-06-01 | 1999-09-07 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| US6024939A (en) * | 1990-06-01 | 2000-02-15 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| CN110478500A (en) * | 2019-08-19 | 2019-11-22 | 吉林省恒光医疗科技有限公司 | A kind of radiography agent prescription and preparation method thereof for ultrasound diagnosis |
| CN115400230A (en) * | 2022-09-03 | 2022-11-29 | 福建医科大学附属协和医院 | Novel multifunctional gastrointestinal ultrasonic contrast agent |
| CN115400230B (en) * | 2022-09-03 | 2023-12-22 | 福建医科大学附属协和医院 | Novel multifunctional gastrointestinal ultrasound contrast agent |
| CN119236122A (en) * | 2024-12-09 | 2025-01-03 | 北京大学第三医院（北京大学第三临床医学院） | Liquid gastrointestinal ultrasound examination reagent and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1024628C (en) | 1994-05-25 |
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Address after: Hangzhou City, Zhejiang province 310002 Shangcheng District Lane No. 95 Patentee after: Hangzhou Huqingyutang Pharmaceutical Co. Ltd. Address before: 323301 Suichang People's Hospital of Zhejiang Province Patentee before: Guo Xinzhang |
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