CN110755646A - Traditional Chinese medicine contrast development aid for stomach ultrasonic contrast examination and preparation method thereof - Google Patents
Traditional Chinese medicine contrast development aid for stomach ultrasonic contrast examination and preparation method thereof Download PDFInfo
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- CN110755646A CN110755646A CN201911286910.XA CN201911286910A CN110755646A CN 110755646 A CN110755646 A CN 110755646A CN 201911286910 A CN201911286910 A CN 201911286910A CN 110755646 A CN110755646 A CN 110755646A
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Abstract
The invention relates to a traditional Chinese medicine contrast developing aid for stomach ultrasonic contrast examination, which comprises the following raw materials in parts by weight: 35 parts of soybean meal, 15 parts of mung bean, 10 parts of corn, 5 parts of Chinese yam, 5 parts of dried orange peel, 3 parts of roasted malt, 2 parts of roasted chicken's gizzard-membrane and sea
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine contrast developing aid for stomach ultrasonic contrast examination, and a preparation method of the formula medicine.
Background
The ultrasonic imaging technique is a commonly used clinical examination means, and has been used for examining parenchymal organs such as liver, spleen and kidney. With the development of the technology, the imaging technology is more and more applied to the imaging of hollow organs such as the stomach and the intestine, because the stomach is often interfered by intestinal gas, the air in the stomach and the intestine needs to be neutralized by an ultrasonic contrast developing-assisting agent before examination, and simultaneously, the sound level difference is formed between the wall structure of the stomach and the surrounding structure, so that the aim of clearly displaying the wall structure of the stomach is fulfilled.
After the contrast developing aid is applied, ultrasonic examination of the stomach is carried out, the sizes and the overall structures of the stomach and the duodenum can be clearly shown, the four-layer fine structures of the cardia, the stomach body and the antrum of the stomach can be clearly shown, and the movement rhythm, the direction and the amplitude of the stomach are observed at the same time, so that the functional states of the stomach and the duodenum are evaluated, and the contrast developing aid has good auxiliary diagnosis effect on the abnormal movement functions of the stomach, such as reflux esophagitis, reflux antrum gastritis, low gastric motility function and the like; for benign and malignant lesions in the stomach, such as diverticula, polyps, tumors, ulcers and the like, the contrast medium makes the lesion and surrounding normal tissues form obvious sound level difference, can measure the size and observe the form of the lesion, and provides effective means for judging the nature of the lesion and understanding the invasion range of the surrounding tissues; exogenous tumors of the stomach wall, such as fibroma and the like, are often difficult to find in traditional gastroscopy and X-ray barium agent examination, and after the gastric contrast agent fills the gastric cavity, the gastric tumors and the stomach wall can form a good sound interface, and the finding probability can be improved to 75-80%.
The existing contrast developing aid has peculiar smell, tastes delicious and is difficult to accept by patients; the contrast developing aid with certain components also has certain stimulation or toxic and side effects on the stomach; in addition, the prior contrast developing aid needs to be processed by a plurality of procedures before being taken, and is inconvenient to use; meanwhile, the cost is high, and further improvement is needed.
Disclosure of Invention
The invention aims to provide a safe, cheap, convenient and toxic-side-effect-free traditional Chinese medicine formula contrast aid for stomach ultrasound contrast.
The invention also aims to provide a preparation method of the contrast agent for ultrasonic contrast in stomach.
The invention relates to a traditional Chinese medicine contrast developing aid for stomach ultrasonic contrast examination, which is characterized by comprising the following raw materials in parts by weight: 35 parts of soybean meal, 15 parts of mung bean, 10 parts of corn, 5 parts of Chinese yam, 5 parts of dried orange peel, 3 parts of roasted malt, 2 parts of roasted chicken's gizzard-membrane and sea2 parts of kurtosis, 0.5 part of ageratum, 2 parts of codonopsis pilosula, 2 parts of eucommia ulmoides, 7 parts of barium sulfate dry powder, 0.5 part of stevia rebaudiana extract and 11 parts of deionized water.
The medicines are combined to enable the efficacies of the medicines to generate synergistic effect, and the medicine is prepared through a corresponding flow process, so that the medicine can be quickly and effectively used for ultrasonic development examination of the stomach.
The soybean meal is a byproduct obtained after soybean oil is extracted from soybeans, is a traditional Chinese medicine with homology of medicine and food, is rich in protein, contains certain carbon hydrate, calcium, magnesium and other components, is used as a base material of the contrast developing aid for gastric wall radiography, has no special food contraindication, and can be eaten by general people. Has effects in strengthening the abdomen, supplementing energy, improving hearing and hearing, strengthening brain, replenishing blood, invigorating qi, enhancing immunity, tranquilizing mind, and relieving restlessness.
Mung bean is another auxiliary base material, is a medicine-food homologous Chinese medicine, and comprises the chemical components of protein, fat, carbohydrate, vitamin B1, B2, carotene, nicotinic acid, folic acid, mineral calcium, phosphorus and iron. Mung bean starch contains a considerable amount of oligosaccharides (pentosan, galactan, etc.) which are difficult to digest and absorb because the stomach tract of a human body does not have a corresponding hydrolase system, so that the mung bean powder provides energy values lower than other grains, and has an auxiliary treatment effect on obese patients and diabetic patients. And oligosaccharide is a proliferation factor of bifidobacterium which is a beneficial bacterium in human intestinal tracts, and the regular consumption of the mung bean powder can improve the intestinal flora, reduce the absorption of harmful substances and prevent certain cancers. The formula mainly enhances the gas adsorption effect of the development aid by using the mung bean powder, reduces the sugar content in the whole formula, ensures that a diabetic can take the mung bean powder, and provides a wider applicable population for the formula.
The corn is sweet and neutral, and has high cellulose content, so that the corn can protect intestines and stomach and promote the gastrointestinal motility. After puffing, through the action of high temperature, high pressure and high shear force, the molecular bond of starch is opened, the surface area of chyme particles is increased, the digestibility is increased, a protein peptide chain is cracked into peptide and AA, and the protein absorption rate is improved. And has natural fragrance and good palatability. Meanwhile, the adhesive property is provided, so that the forming and stability coefficient of the development aid particles are greatly increased.
The yam is sweet in taste, tonifying but not greasy, fragrant but not dry, and has a good effect of treating diarrhea due to spleen deficiency. Is a mild nourishing and strengthening medicine, strengthens the spleen, strengthens the stomach, widens the intestine and has better curative effect on chronic diarrhea with hypofunction of the stomach.
The patchouli and the dried orange peel can regulate qi, eliminate stagnation and flatulence and are raw materials for eliminating gas in stomach.
The fried chicken's gizzard-membrane and the fried malt have the functions of invigorating stomach and helping digestion, promoting gastric peristalsis to discharge gas downwards, and the functions of regulating qi, eliminating flatulence, strengthening spleen, eliminating dampness and astringing are achieved together, and gas and emulsion in the stomach are removed automatically.
The dartlike sea-like food can invigorate spleen and resolve dampness, and is used as a raw material for removing stomach milk; dangshen and eucommia bark, radix Codonopsis, strengthen the middle warmer and replenish qi.
The barium sulfate dry powder mainly plays a defoaming role in the formula. The stevia extract has the effects of regulating taste and improving palatability. The deionized water is mainly used for mixing medicaments and is matched with the effect of particle forming.
The medicines are matched to have the effects of regulating qi and eliminating dampness, improving microcirculation of gastric mucosa, promoting absorption of gastric fluid and the like, have the functions of nursing and health care on the stomach, are beneficial to the health of the stomach and intestine, and can effectively prevent and treat gastrointestinal diseases, thereby having multiple comprehensive functions of diagnosis, nursing, treatment and the like.
A preparation method of a traditional Chinese medicine contrast development aid for stomach ultrasonic contrast examination is characterized by comprising the following steps:
(1) mixing soybean meal and corn flour, puffing, pulverizing, and sieving with 80 mesh sieve;
(2) soaking semen Phaseoli Radiati in clear water, draining, drying, pulverizing, steaming, oven drying at low temperature, pulverizing again, and sieving with 80 mesh sieve;
(3) oven drying rhizoma Dioscoreae, pericarpium Citri Tangerinae and fructus Hordei Germinatus preparata at low temperature, pulverizing with pulverizer, and sieving with 80 mesh sieve;
(4) taking endothelium corneum Gigeriae Galli and sea food
Aging kurtosis, herba Agastaches, radix Codonopsis and Eucommiae cortex, pulverizing, and sieving with 80 mesh sieve;
(5) mixing the above processed materials, adding barium sulfate powder and sweet stevia extract, and stirring in a stirrer;
(6) pouring the stirred mixture into deionized water, granulating on a particle forming machine, instantly sterilizing at high temperature, vacuum drying at low temperature, and vacuum packaging.
Preferably, the soaking time in the step (2) is 24 hours.
Compared with the prior art, the invention has obvious beneficial effects, and the technical scheme can show that: the invention is prepared by selecting common traditional Chinese medicines and medicines with homology of medicine and food, has the advantages of easily obtained materials, safety, no toxicity, proper price, relatively simple process, convenient use and excellent effect, and has the advantages of diagnosis and treatment homology.
Detailed Description
A traditional Chinese medicine contrast developing aid for stomach ultrasonic contrast examination comprises the following raw materials in parts by weight: 30-40 parts of soybean meal, 10-30 parts of mung bean, 5-20 parts of corn, 2-10 parts of Chinese yam, 2-15 parts of dried orange peel, 1-8 parts of roasted malt, 1-5 parts of roasted chicken's gizzard-membrane, sea water
1-2 parts of kurtosis, 0.1-0.8 part of patchouli, 1-6 parts of codonopsis pilosula, 1-5 parts of eucommia ulmoides, 3-12 parts of barium sulfate dry powder, 0.2-0.6 part of stevia rebaudiana extract and 5-20 parts of deionized water.
Example (b): a preparation method of a traditional Chinese medicine contrast development aid for stomach ultrasonic contrast examination comprises the following steps:
(1) mixing 35 parts of soybean meal and 10 parts of corn flour, puffing, crushing, and sieving by a 80-mesh sieve;
(2) soaking 10 parts of mung bean in clear water for 24 hours, draining, drying, crushing by a crusher, steaming in a steamer, drying at low temperature, crushing again, and sieving by a 80-mesh sieve;
(3) taking 5 parts of Chinese yam, 5 parts of dried orange peel and 3 parts of roasted malt, drying at low temperature, crushing by a crusher, and sieving by a 80-mesh sieve;
(4) taking fried chicken's gizzard-membrane 1 part and sea
3 parts of kurtosis, 0.5 part of ageratum, 2 parts of codonopsis pilosula and 2 parts of eucommia ulmoides, curing, crushing and sieving by a 80-mesh sieve;
(5) mixing the products obtained after the steps, adding 7 parts of barium sulfate dry powder and 0.5 part of stevia rebaudiana extract, and uniformly stirring in a stirrer;
(6) taking 11 parts of deionized water, pouring the stirred product into the deionized water, granulating on a particle forming machine, instantly sterilizing at high temperature, vacuum drying at low temperature, and vacuum packaging with 50 g per bag for later use.
The using method comprises the following steps: opening a bag of vacuum-packed traditional Chinese medicine contrast developing aid of 50 g, pouring the bag into a disposable cup with the volume of 500 ml, pouring 300 ml of deionized water at the temperature of 100 ℃, stirring the mixture for 2 minutes clockwise to enable the traditional Chinese medicine contrast developing aid to be uniform and thin paste, standing the paste, cooling the paste to the temperature of about 26 ℃, drinking the paste once, and immediately carrying out ultrasonic examination.
Test example: 3420 patients with the maximal age of 91 years, the minimal age of 5 years, male 2112 and female 1308 were selected from 3 months in 2011 to 3 months in 2019 for stomach ultrasound contrast examination in the ultrasound department of the hospital.
The examiner takes an empty stomach in the morning, and the ultrasonic examination of the upper abdomen is performed before the examination, so that the preliminary understanding of the sound transmission condition and the conditions of the liver, gallbladder, pancreas, spleen and kidney of the upper abdomen is realized, and other organ diseases except the pathological changes of the stomach are also realized. And then drinking 300 ml of the prepared traditional Chinese medicine contrast aid at one time, reducing the dosage for the young and the single-thin patients, laying on an ultrasonic examination bed after taking, sequentially and ultrasonically scanning the conditions of cardia, the corpus gastri, antrum gastri and duodenum, observing the wall thickness, the conditions of the inner and outer layers, the motion amplitude and the frequency of each part in detail, carrying out amplification observation on abnormal conditions, carrying out photograph recording, and finally forming a diagnosis report.
Image standard: the image is good: can clearly display the internal and external hierarchical structures of the stomach and the duodenum wall, has no interference of gas and mucus in the stomach cavity, and can successfully form images. The image is generally: the internal and external hierarchical structures of the stomach and the duodenum wall can be displayed, a small amount of gas and mucus in the stomach cavity are interfered, the interference can be overcome by posture change and pressing, and the inspection result is not influenced. Poor image: the contour of the stomach and the duodenum cavity can be displayed, more gas and mucus are interfered, and the internal and external structures of partial stomach and duodenum walls are difficult to clearly display. Poor image: the large amount of gas and mucus interferes with the general lack of visibility of the stomach, duodenal contours, and the hierarchical structure of the intestinal wall.
And (4) checking results: 3420 patients in this group showed good 2922, generally 317, 147 and 34 poor images. The reason for poor image and the influence on poor cases is analyzed: gastric and duodenal obstruction is common, a large amount of retention exists in the stomach, the stomach cannot be emptied, and the stomach occupies the space of the ultrasonic development aid and cannot play a role. Some serious systemic diseases, such as exhaustion, esophageal obstruction, anorexia, etc. can not be administered smoothly.
The ultrasonic contrast examination of the group shows 214 positive cases, wherein 154 cases of gastric and duodenal ulcers, 8 cases of gastric and duodenal diverticulums, 36 cases of gastric polyps, 11 cases of gastric cancers and 5 cases of extragastric tumors. The above cases were verified by gastroscopy, pathological examination, epigastric CT and magnetic resonance verification.
And (4) adverse reaction observation: in all cases, no toxic or side effects such as allergy, abdominal pain caused by medicines, nausea, vomiting, diarrhea, discomfort, change of liver and kidney functions and the like are found. The examinee generally reflects the traditional Chinese medicine contrast aid taste is light and comfortable to drink. From this it can be deduced: the traditional Chinese medicine contrast developing aid is simple and convenient to use, clear in imaging, safe, free of toxic and side effects, high in clinical applicability and worthy of popularization.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those skilled in the art that various changes in the embodiments and modifications thereof may be made, and equivalents may be substituted for elements thereof; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (3)
1. Stomach ultrasonic instrumentThe traditional Chinese medicine contrast developing aid for acoustic contrast examination is characterized by comprising the following raw materials in parts by weight: 35 parts of soybean meal, 15 parts of mung bean, 10 parts of corn, 5 parts of Chinese yam, 5 parts of dried orange peel, 3 parts of roasted malt, 2 parts of roasted chicken's gizzard-membrane and sea
2 parts of kurtosis, 0.5 part of ageratum, 2 parts of codonopsis pilosula, 2 parts of eucommia ulmoides, 7 parts of barium sulfate dry powder, 0.5 part of stevia rebaudiana extract and 11 parts of deionized water.
2. A preparation method of a traditional Chinese medicine contrast development aid for stomach ultrasonic contrast examination is characterized by comprising the following steps:
(1) mixing soybean meal and corn flour, puffing, pulverizing, and sieving with 80 mesh sieve;
(2) soaking semen Phaseoli Radiati in clear water, draining, drying, pulverizing, steaming, oven drying at low temperature, pulverizing again, and sieving with 80 mesh sieve;
(3) oven drying rhizoma Dioscoreae, pericarpium Citri Tangerinae and fructus Hordei Germinatus preparata at low temperature, pulverizing with pulverizer, and sieving with 80 mesh sieve;
(4) taking endothelium corneum Gigeriae Galli and sea food
Aging kurtosis, herba Agastaches, radix Codonopsis and Eucommiae cortex, pulverizing, and sieving with 80 mesh sieve;
(5) mixing the above processed materials, adding barium sulfate powder and sweet stevia extract, and stirring in a stirrer;
(6) pouring the stirred mixture into deionized water, granulating on a particle forming machine, instantly sterilizing at high temperature, vacuum drying at low temperature, and vacuum packaging.
3. The preparation method of the traditional Chinese medicine contrast developing aid for the ultrasonic contrast examination of the stomach according to claim 2, which is characterized in that: the soaking time in the step (2) is 24 hours.
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