CN103006527A - acne removing liquid - Google Patents

Abstract

The invention relates to an acne-removing liquid, which belongs to the field of cosmetics. An acne-removing liquid, comprising the following components: component A: propylene glycol, xanthan gum, the first solvent; component B: hexyl ether diisethionate, vitamin B6, the second solvent; component C: plant extract liquid, azelaic acid derivatives, inulin, salicylic acid, ginseng extract, vitamin E, preservatives. The present invention has the functions of treating acne and skin whitening. Its effect is obvious, the effect is fast, there is no acne scar after healing, and it is not easy to relapse. It also has the functions of skin rejuvenation, moisturizing, reducing oil secretion and promoting cell metabolism. A cosmetic product for the prevention and treatment of acne and skin whitening.

Description

an acne solution

technical field

The invention relates to the field of cosmetics, in particular to an acne-removing liquid.

Background technique

Acne, commonly known as acne, is a chronic inflammatory pilosebaceous disease and is one of the most common diseases in dermatology.

The main causes of acne on the skin are:

1. Due to the strong secretion of sebaceous glands, excessive oil, enlarged or blocked pores, and thickened stratum corneum are caused. Therefore, the oil gradually rises to the surface of the cortex, which causes the oil to block the pores, and the raised apex oxidizes and turns black, which leads to bacterial infection. It mixes with oil in the pores, causing Propionibacterium acnes to proliferate in a large number under hypoxic conditions, and then leads to the invasion of inflammatory bacteria, turning into pustules and nodules, and finally the entire hair follicle becomes red and inflamed.

2. The dryness of the skin is also the cause of acne, because the skin lacks moisture and is too dry. In order to moisturize the skin, it will secrete too much oil.

3. Endocrine disorders.

In terms of acne removal, it is necessary to start from the following aspects: 1) improve the moisturizing effect of the skin; 2) regulate the oil balance of the skin and inhibit the excessive secretion of sebum; 3) inhibit the propagation of Propionibacterium acnes; 4) have certain 5) remove acne marks; 6, regulate endocrine.

Acne-removing products currently on the market have a single effect and cannot provide comprehensive care for acne on the skin.

Contents of the invention

Aiming at the deficiencies in the prior art, the problem to be solved by the present invention is to provide an acne-removing liquid, which is used for the prevention and treatment of acne, and there is no acne or trace after the cure.

In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is:

A kind of anti-acne liquid, by weight percentage, comprises the following components:

Component A: 2%-10% propylene glycol, 0.5%-3% xanthan gum, 55%-65% first solvent;

Component B: 0.02% to 0.3% of hexyl ether diisethionate, 0.1% to 1.2% of vitamin B6, 3% to 7% of the second solvent;

Component C: 10%-30% of plant extract, 0.5%-4% of azelaic acid derivative, 1%-5% of inulin, 0.1%-1% of salicylic acid, 0.2%-2% of ginseng extract , vitamin E 0.1% to 1.0%, preservatives 0.1% to 0.8%.

Preferably, by weight percentage, the following components are included:

Component A: propylene glycol 3%-7%, xanthan gum 0.8%-2%, first solvent 55%-65%;

Component B: 0.05% to 0.1% of hexyl ether diisethionate, 0.2% to 0.9% of vitamin B6, 3% to 7% of the second solvent;

Component C: 15%-25% of plant extract, 1%-4% of azelaic acid derivative, 2%-5% of inulin, 0.2%-1% of salicylic acid, 0.5%-2% of ginseng extract , vitamin E 0.3% to 1.0%, preservatives 0.1% to 0.5%.

Preferably, by weight percentage, the following components are included:

Component A: propylene glycol 5%, xanthan gum 1%, first solvent 60%;

Component B: 0.08% hexyl ether diisethionate, 0.5% vitamin B, 5% second solvent;

Component C: 20% plant extract, 2% azelaic acid derivative, 3% inulin, 0.5% salicylic acid, 1% ginseng extract, 0.6% vitamin E, and 0.3% preservative.

Preferably, both the first solvent and the second solvent are deionized water.

Preferably, the plant extract is one or more of honeysuckle, aloe vera, Atractylodes macrocephala, salvia miltiorrhiza, psyllium, Kochia chinensis, Cnidium chinensis, Chuanhuanglian, mother-of-pearl, turmeric, and basil.

Preferably, the preservative is Genma BP.

Preferably, the C component also includes essence or solubilizer.

Further, the essence is lavender essence, and the weight percentage of the essence is 0.05%-0.1%.

Further, the solubilizer is polyoxyethylene ether-40 hydrogenated castor oil, and its weight percentage is 0.1%-0.3%.

The beneficial effects of the present invention are: the present invention has the functions of treating acne and skin whitening, the effect is obvious, the effect is fast, there is no acne scar after healing, it is not easy to relapse, and it has the functions of skin rejuvenation, moisturizing, reducing oil secretion and promoting cell metabolism Function, the present invention is a kind of cosmetics for prevention and treatment of acne and skin whitening.

Detailed ways

The examples described in the present invention are to illustrate the present invention but not to limit the present invention. Any changes and adjustments within the equivalent meaning and scope of the present invention shall be considered within the scope of the present invention.

The present invention will be further described below in conjunction with embodiment.

Example 1

A kind of anti-acne liquid, by weight percentage, comprises the following components:

Component A: 2% propylene glycol, 0.5% xanthan gum, 55% first solvent;

Component B: 0.02% hexyl ether diisethionate, 0.1% vitamin B6, 3% second solvent;

Component C: 10% plant extract, 0.5% azelaic acid derivative, 1% inulin, 0.1% salicylic acid, 0.2% ginseng extract, 0.1% vitamin E, 0.1% preservative, and 0.1% essence.

Its preparation method is:

1) Heat the component A until the temperature _T1 is 85°C, and at the same time start the stirrer to stir until it dissolves completely;

2) Dissolve the component B at a temperature _T2 of 25°C, stir with the agitator until it dissolves completely;

3) Use cooling water to stir and lower the temperature of component A that has been completely dissolved in step 1 until the temperature _T3 is 45°C, then add component B that has been completely dissolved in step 2, stir while adding, and wait for the After the addition of component B is completed, start the homogenizer to emulsify for 10 minutes;

4) Add the C component into the mixture obtained in the step 3, stir while adding, wait until it is completely dissolved, stir evenly, and vacuum until the liquid surface is free of bubbles;

5) Open the cooling water in the interlayer, cool to the temperature _T4 38°C and discharge, that is, the acne-removing liquid is made.

The first solvent and the second solvent may be purified water or deionized water, preferably deionized water in this embodiment.

In the present invention, the effect of each component is respectively: Propylene glycol is generally used as hygroscopic agent, antifreeze agent, lubricant, is used in the present invention to make the solvent and softener of acne-removing liquid; Xanthan gum plays thickening , suspending, emulsifying, stabilizing effect; Dihydroxyhexyl ether hexyl ether is used as a bactericide for the skin in the present invention, has good acne removal effect, and can also be used as a preservative; Vitamin B6 is a component of some coenzymes in the human body, participates in A variety of metabolic reactions, especially closely related to amino acid metabolism, produce antibodies, regulate the central nervous system, and maintain skin health in the present invention.

The Chinese medicines in the present invention all meet the standard of "Chinese Pharmacopoeia". The principle of prescription of the present invention is based on the nature, taste, return, meridian, function and indication of each flavor of Chinese medicines and the principle of four diagnosis and eight rigidities of traditional Chinese medicine, syndrome differentiation and treatment. The plant extract is an extract composed of one or more of honeysuckle, aloe, Atractylodes macrocephala, Danshen, plantago, Kochia scoparia, Cnidium chinensis, Chuanhuanglian, mother of pearl, turmeric and basil. Extraction is the removal from a substance (such as a constituent or juice) by treatment with a solvent (such as ethanol), distillation, dehydration, subjecting to pressure or centrifugal force, or by other chemical or mechanical processes. Plant extracts are various components separated from the fibers, essences, nourishing liquids and other substances in plants through chemical or mechanical processes.

Honeysuckle: Known as the "Pharmaceutical Fairy", it contains cyclohexanol, flavonoids, inositol, saponins and tannins, etc. It has heat-clearing and detoxifying effects, enhances cellular immunity and broad-spectrum antibacterial effects, and can effectively cure acne and acne , blackheads and other phenomena.

Wild chrysanthemum: It contains inulin, coumarin, and wild chrysanthemum lactone, which has heat-clearing, detoxifying, and antibacterial effects, and can treat boils, carbuncles, and erysipelas.

Aloe Vera: It has the functions of astringent, softening, moisturizing, anti-inflammatory, bleaching, skin absorption and tightening, and it can also relieve hardening, keratinization, and improve scars. It can not only prevent small wrinkles, bags under the eyes, and sagging skin, but also maintain The skin is moist and delicate. At the same time, it can also treat skin inflammation. It also has a good effect on acne, freckles, acne, burns, knife wounds, and insect bites.

Atractylodes macrocephala: Contains volatile oil (atractylone, atractylodes lactone, mannan, amino acid) and other ingredients, has anti-oxidation, antibacterial, whitening and brightening skin tone, immune enhancement and immune regulation and other pharmacological effects, and can gradually eliminate and recede freckles .

Salvia miltiorrhiza: promoting blood circulation to remove blood stasis, cooling blood to eliminate carbuncle, clearing heat, detoxifying and anti-inflammatory, used for acne, lumps, carbuncle, sores, etc.

Psyllium: Lishui Tonglin, has the effect of activating the skin.

Kochia chinensis: clearing damp-heat, used for skin itching due to damp-heat.

Fructus Cnidii: Contains osthole, volatile oil (levopinene and bornyl isoate), etc., has hormone-like effects, and can inhibit trichomonas, epidermophyton flocculus, Newcastle virus, influenza virus, and its extracts still have Anthelmintic effect. It has the effects of expelling wind and dampness, killing insects and relieving itching, and nourishing kidney qi.

Chuanhuanglian: Contains alkaloids, phellodendron, phellodendron lactone and other ingredients, has the functions of purging fire and detoxification, clearing heat and dampness, antibacterial, antibacterial and antiviral, antiprotozoal, acne, and regulating oil. High fever and irritability, aphtha, carbuncle to treat poison embolism.

Mother of Pearl: The main ingredients are calcium carbonate, taurine, trace elements, amino acids (glycine, methionine, alanine, leucine, glutamic acid, etc.), which can effectively regulate the human central nervous system and endocrine. It helps to improve skin quality comprehensively and permanently, and has the functions of removing freckles, removing acne, beautifying, delaying aging, improving human endocrine, promoting metabolism, enhancing physical fitness, whitening, and brightening skin tone. Suitable for patients with chloasma.

Curcuma: Dispels blood stasis and moisturizes the skin.

Baibu: Rich in alkaloids, it has the effect of killing insects and removing mites.

Azelaic acid derivatives are potassium salts prepared by reacting azelaic acid with amino acids. They are potassium salts of azelaic acid amino acids, and their structural formula is R1-CO(CH ₂ ) ₇ CO-R2-COOK. It has the characteristics of low concentration of activity, excellent chemical stability and good compatibility. It is a multifunctional new cosmetic raw material, which plays the role of whitening and removing spots, regulating oil and moisturizing in the present invention.

Shofurin (SHF) is a complex extract extracted from the roots of wild Vitexaceae shade plants, which contains a variety of amino acids, saponins and safflower. It has the effect of enhancing the immune function of the body cells and anti-pathological effects, especially its main component chrysanthemum vitamin, also known as chrysanthemum root vitamin. Because of its unique molecular structure of dihydroxyl and diamino groups, it can effectively activate the immune function of skin cells. It is an ideal immune-enhancing antisensitivity agent newly discovered in recent years, and plays an antiallergic role in the present invention.

Salicylic acid can be used to exfoliate sensitive and seborrheic skin. Salicylic acid has fat-soluble properties, which can lock the effect in the superficial stratum corneum without affecting the active epidermal cells. In the present invention, salicylic acid is used as cuticle softener, antipruritic and antifungal.

The important component of ginseng extract is total ginsenoside, which is extracted and refined from the root, stem and leaf of Araliaceae plant ginseng, which is rich in eighteen kinds of ginseng monomer saponins, soluble in 80 °C Water, easily soluble in ethanol. Long-term use can prolong life and enhance physical strength; it has the effect of resisting cold and heat stress. At the same time, it has the functions of enhancing the vitality of human surface cells and inhibiting aging. In the present invention, the ginseng extract can be used for removing spots, reducing wrinkles, activating skin cells, and enhancing skin elasticity.

Vitamin E (Vitamin E) is a fat-soluble vitamin, also known as tocopherol, is one of the most important antioxidants, soluble in organic solvents such as fat and ethanol, insoluble in water, stable to heat and acid, not to alkali Stable, sensitive to oxygen, insensitive to heat. In the present invention, it plays the role of activating skin cells, effectively reducing wrinkles and maintaining youthful appearance.

The antiseptic used daily has benzalkonium bromide or Genma BP, and the chemical name of Genma BP is two (hydroxymethyl) imidazolidinyl urea or iodopropynyl butyl carbamate (IPBC), the present invention Among them, the preferred preservative is Genma BP.

Phase A is mainly used as a solvent, phase B is mainly composed of chemical components, and phase C is mainly composed of Chinese herbal medicine components. The purpose of separating phase A, phase B and phase C is mainly to better dissolve all the ingredients in the formula.

In the present invention, component C also includes essence, which can be selected from lavender essence, lemon essence or aloe essence, and the preferred essence in this implementation is lavender essence.

In the preparation method step 1 of the present invention, the temperature _T1 is selected to be 85°C, because the temperature is too low to make the A component dissolve incompletely, and the A component will volatilize if the temperature is too high; in the step 2, the selected temperature _T2 is 25°C , the reason is that if the temperature is too low, component B will not dissolve completely, and if the temperature is too high, component A will volatilize; when emulsifying in step 3, the emulsification batching tank is used, which is equipped with a vacuum device and an interlayer water device to meet the requirements of the step The completion of four and step five, thereby making the acne-removing liquid finished product.

Example 2

A kind of anti-acne liquid, by weight percentage, comprises the following components:

Component A: 3% propylene glycol, 0.8% xanthan gum, 55% first deionized water;

Component B: 0.05% hexyl ether diisethionate, 0.2% vitamin B6, 3% second deionized water;

Component C: plant extract 15%, azelaic acid derivative 1%, inulin 2%, salicylic acid 0.2%, ginseng extract 0.5%, vitamin E 0.3%, Genma BP 0.1%, lavender essence 0.1 %.

Example 3

A kind of anti-acne liquid, by weight percentage, comprises the following components:

Component A: Propylene Glycol 5%, Xanthan Gum 1%, First Deionized Water 60%;

Component B: 0.08% hexyl ether diisethionate, 0.5% vitamin B6, 5% second deionized water;

Component C: plant extract 20%, azelaic acid derivatives 2%, inulin 3%, salicylic acid 0.5%, ginseng extract 1%, vitamin E 0.6%, Genma BP 0.3%, lavender essence 0.075 %.

Example 4

A kind of anti-acne liquid, by weight percentage, comprises the following components:

Component A: Propylene Glycol 7%, Xanthan Gum 2%, First Deionized Water 65%;

Component B: 0.1% hexyl ether diisethionate, 0.9% vitamin B6, 7% second deionized water;

Component C: plant extract 25%, azelaic acid derivative 4%, inulin 5%, salicylic acid 1%, ginseng extract 2%, vitamin E 1.0%, Genma BP 0.5%, lavender essence 0.05 %.

Example 5

A kind of anti-acne liquid, by weight percentage, comprises the following components:

Component A: 10% propylene glycol, 3% xanthan gum, 65% first solvent;

Component B: 0.3% hexyl ether diisethionate, 1.2% vitamin B6, 7% second solvent;

Component C: 30% plant extract, 4% azelaic acid derivative, 5% inulin, 1% salicylic acid, 2% ginseng extract, 1.0% vitamin E, 0.8% Genma BP, 0.05 lavender essence %.

Example 6

Same as Example 3, the difference is:

The C component does not contain essence, but contains a solubilizer, which is a viscous liquid or paste, and is an excellent non-ionic solubilizer and emulsifier; it has a wide range of pH stability, low foam , can form a clear mixture with fatty acids and fatty alcohols at high temperature. The solubilizer can be selected from polyoxyethylene ether-40 hydrogenated castor oil or polyoxyethylene ether-40 hydrogenated castor oil, and polyoxyethylene ether-40 hydrogenated castor oil is preferred in this embodiment, and its weight percentage is 0.1%.

Example 7

Same as Example 6, the difference is:

The solubilizer polyoxyethylene ether-40 hydrogenated castor oil is 0.2% by weight.

Example 8

Same as Example 6, the difference is:

The solubilizer polyoxyethylene ether-40 hydrogenated castor oil is 0.3% by weight.

Example 9

The present invention complies with the National Hygienic Standard for Cosmetics GB 7916-1987, and the curative effect experiment is now conducted on the acne-removing liquids of different formulations in Examples 1-8.

Clinical effect: Acne removal.

Specific operation method: 80 people aged 19 to 21 years old are doing clinical experiments, divided into 8 groups, 10 people in each group, let each group try out Example 1-8 respectively, and the specific operation method is to apply the acne-removing liquid On the affected area, it is better to smear the area larger than the affected area. In order not to affect the work or study of the patient, it can be treated at night while sleeping, and it can be washed with warm water after getting up in the morning. Course of treatment: not less than 100 hours, the treatment time is in place, and there will be no rebound after curing. Table 1 is the therapeutic effect comparison table of Embodiment 1-8, as shown in Table 1.

Therapeutic effect comparative table of table 1 embodiment 1-8

Example Number of people in each group treatment effect Cure rate (%) Remark 1 10 generally 78 1 person is allergic treatment is invalid 2 10 generally 90 3 10 optimal 100 4 10 good 90 5 10 good 80 6 10 good 90 7 10 optimal 100 8 10 good 90

As can be seen from Table 1, the therapeutic effect of embodiment 3 and embodiment 7 is the best. Adding essence or solubilizer in the formula of the acne-removing liquid has no influence on the therapeutic effect of the acne-removing liquid. The best formula is:

Component A: 5% propylene glycol, 1% xanthan gum, 60% deionized water;

Component B: 0.08% hexyl ether diisethionate, 0.5% vitamin B6, 5% deionized water;

Component C: plant extract 20%, azelaic acid derivatives 2%, inulin 3%, salicylic acid 0.5%, ginseng extract 1%, vitamin E 0.6%, Genma BP 0.3%, lavender essence 0.075 %.

Or the best formula for acne solution is:

Component A: 5% propylene glycol, 1% xanthan gum, 60% deionized water;

Component B: 0.08% hexyl ether diisethionate, 0.5% vitamin B6, 5% deionized water;

Component C: Plant Extract 20%, Azelaic Acid Derivatives 2%, Inulin 3%, Salicylic Acid 0.5%, Ginseng Extract 1%, Vitamin E 0.6%, Genma BP 0.3%, Polyoxyethylene Ether-40 Hydrogenated Castor Oil 0.2%.

Example 10

The performance test of the acne-removing liquid in Example 3 and Embodiment 7 is performed, and its specific data table is shown in Table 2, and Table 2 is the performance test table of the acne-removing liquid.

Table 2 Acne Removing Liquid Performance Test Form

performance testing Example 3 Example 7 pH value(25℃) 5.0～7.0 5.0～7.0 Viscosity (25℃, mpa.s) qualified qualified Centrifugation (38°C, 300r/min, 30min) qualified qualified Density (20℃, g/ml) qualified qualified Turbidity (5-10°C) qualified qualified Foam volume (40℃, mm) qualified qualified Cold resistance (-5℃-15℃, observe after 48h) No abnormality No abnormality Heat resistance (48±1℃, observe after 48h) No abnormality No abnormality Total number of bacteria (cfu/g) <10 <10

The present invention has the functions of treating acne and skin whitening. Its effect is obvious, the effect is fast, there is no acne scar after healing, and it is not easy to relapse. It also has the functions of skin rejuvenation, moisturizing, reducing oil secretion, and promoting cell metabolism. A cosmetic product for the prevention and treatment of acne and skin whitening.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the scope of the present invention. within the scope of protection.

Claims (9)

1. an antiacne liquid, is characterized in that, by weight percentage, comprises following component: Component A: 2%-10% propylene glycol, 0.5%-3% xanthan gum, 55%-65% first solvent; Component B: 0.02% to 0.3% of hexyl ether diisethionate, 0.1% to 1.2% of vitamin B6, 3% to 7% of the second solvent; Component C: 10%-30% of plant extract, 0.5%-4% of azelaic acid derivative, 1%-5% of inulin, 0.1%-1% of salicylic acid, 0.2%-2% of ginseng extract , vitamin E 0.1% to 1.0%, preservatives 0.1% to 0.8%. 2. acne liquid as claimed in claim 1, is characterized in that, by weight percentage, comprises following component: Component A: propylene glycol 3%-7%, xanthan gum 0.8%-2%, first solvent 55%-65%; Component B: 0.05% to 0.1% of hexyl ether diisethionate, 0.2% to 0.9% of vitamin B6, 3% to 7% of the second solvent; Component C: 15%-25% of plant extract, 1%-4% of azelaic acid derivative, 2%-5% of inulin, 0.2%-1% of salicylic acid, 0.5%-2% of ginseng extract , vitamin E 0.3% to 1.0%, preservatives 0.1% to 0.5%. 3. acne liquid as claimed in claim 1, is characterized in that, by weight percentage, comprises following component: Component A: propylene glycol 5%, xanthan gum 1%, first solvent 60%; Component B: 0.08% hexyl ether diisethionate, 0.5% vitamin B6, 5% second solvent; Component C: 20% plant extract, 2% azelaic acid derivative, 3% inulin, 0.5% salicylic acid, 1% ginseng extract, 0.6% vitamin E, and 0.3% preservative. 4. The acne-removing liquid according to claim 1, 2 or 3, wherein both the first solvent and the second solvent are deionized water. 5. The anti-acne solution according to claim 1, 2 or 3, characterized in that: the plant extracts are honeysuckle, aloe, Atractylodes macrocephala, salvia miltiorrhiza, psyllium, Kochia scoparia, cnidium, chuanhuanglian, pearl One or more of mother, turmeric and hundred. 6. The anti-acne liquid according to claim 1, 2 or 3, characterized in that: the preservative is Genma BP. 7. The anti-acne liquid according to claim 1, 2 or 3, characterized in that: said component C also includes essence or solubilizer. 8. The acne-removing liquid according to claim 7, characterized in that: the essence is lavender essence, and the percentage by weight of the essence is 0.05%-0.1%. 9. The anti-acne liquid according to claim 7, characterized in that: the solubilizer is polyoxyethylene ether-40 hydrogenated castor oil, and its weight percentage is 0.1%-0.3%.