CN1029294C - Therapy device for curing brain disease with brain wave information feedback - Google Patents
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Abstract
The present invention relates to a treatment instrument for brain diseases by brain wave information feedback, which belongs to the technical field of electronic medical instruments controlled by computers. The present invention comprises a brain wave signal collection amplification part, a signal analysis and feedback part, a feedback execution and treatment result output part, etc., namely hardware of a brain wave signal amplification filter, an A/D conversion board, a host of a computer with a coordinator, a keyboard externally arranged, a soft and hard dual driver, a display, a loud speaker, a D/A conversion board, an electromagnetic field stimulator, etc., and software programs of an initialization module, a brain wave data collection and analysis module, a brain wave real-time feedback control module, a CRT display module, etc. A clinical application research proves that the present invention has obvious treatment effect on brain diseases and the advantages of rapid treatment effect, high safety, no pain and no side effect, and can be widely applied to medical health care departments.
Description
The present invention relates to a kind of micro-processor controlled therapy device for curing brain disease with brain wave information feedback of using, belong to the sub-Medical Instruments technical field of microcomputer controlled electro.
Extensively carried out the research of biofeedback (Biofeedback) and biological effect of magnetic field (Biological effect of magnetic field) at present both at home and abroad.Aspect biofeedback, brain electricity (EEG) is very fast with myoelectricity (EMG) biofeedback progress ratio.Reported the brain electricity abroad, the myoelectricity biofeedback has curative effect to childhood hyperkinetic syndrome, studies show that, can promote alpha rhythm in the brain electricity (alpha rhythm) effectively by brain electricity biofeedback, and the patient with alpha rhythm reduction or disappearance disease is had certain therapeutical effect.Biofeedback therapy is to regulate self pathological process by patient's subjective consciousness, reach therapeutic purposes, so this Therapeutic Method cycle is longer, and produce effects is slow.Electromagnetotherapy and equipment thereof have obtained application more and more widely, but present existing electromagnetism therapeutic apparatus is because the signal intensity and the frequency range of its generation and be not suitable for treating the nervous system brain diseases.As Chinese patent CN2060075U is to serve as according to simulating the instrument that bio information carries out feedback treating with the human body myoelectricity, and this therapeutic instrument only is made up of hardware, and right and wrong are intelligentized, can not adjust therapeutic scheme automatically according to patient's characteristics, produce the treatment signal of the best.Therefore this instrument is basic engineering with the myoelectricity in addition, has influenced the curative effect that is used for the treatment of with brain electricity brain diseases in close relations.Chinese patent CN87106336A has related to a kind of electromagnetism armarium for the treatment of with the synchronous low frequency pulsed magnetic fields of heartbeat of using, and output signal frequency is 0.5-2Hz.The signal of this frequency is disadvantageous to cerebral nervous system.The Chinese patent CN85104357A of U. S. application has pulse and shows skin stimulation device, is that the stimulation electric pulse is given and the patient skin electrode in contact, by electricity the stimulation of nerve is come eliminate pain.Patient has the sense of discomfort of pain when treating with it, this mode can only the neural and treatment pain diseases associated in chafe surface.
As sickness rate height such as cerebrovascular, brain atrophy, cerebral trauma, migraine, epilepsies, that causes is very harmful for nervous system brain diseases (Brain Disease).Brain diseases is directly related with nervous system, all can cause the unusual of the change of brain electricity basilic rhythm and brain electrical acti.Some medicines are not remarkable to the curative effect of this class disease, and what have also has a toxic and side effects.Existing in addition physiotherapeutic instruments is not to design at the brain diseases characteristics, may cause damage to cerebral nervous system.
The objective of the invention is to remedy the deficiency of prior art, provide a kind of by micro-processor controlled therapy device for curing brain disease with brain wave information feedback.
The human body electroencephalogram can be divided into delta rhythm, theta rhythm, alpha rhythm, beta response by frequency content.Nervous system brain diseases patient can descend or disappearance with brain electricity alpha rhythm, and the electrical activity wave amplitude is low, slow movable increasing, and epileptic patient also has the spike and ware wave granting.
These characteristics at brain diseases, utilize brain electricity biofeedback and biological effect of electromagnetic field, regulate patient's brain electrical acti, promote alpha rhythm, improve the brain wave width of cloth, suppress slow wave or spike and ware wave and occur, and then improve cranial nerve cell electrical activity and metabolism, reduce cerebral vascular resistance, increase blood circulation, improve brain to oxygen utilization rate, improve brain microcirculation, reach the purpose of treatment brain diseases.
Brain electric information feedback treating instrument is according to above-mentioned principle design, and its midbrain electricity biofeedback is cue with sound, is used to point out the good with poor of patient's brain electricity index.Studies show that the human brain magnetic field intensity is about 10
-8The Gs order of magnitude.The electromagnetic field of instrument generation is between 0～10Gs in view of the above, and frequency is at 8～10Hz.This electromagnetic field places on the relevant acupuncture point with other of patient head lesion, and its intensity, frequency and spatial distribution all can be by computer according to patient's brain electricity real-time analysis result is regulated automatically.
People and therapeutic instrument have constituted an integral body in the therapeutic process.Patient can pass through biofeedback on the one hand, makes great efforts to regulate E.E.G by means of subjectivity, and the then constantly real-time Measurement and analysis patient brain electrical acti of therapeutic instrument is adjusted electromagnetic signal on the other hand, makes patient be in the optimal treatment state.Patient and instrument have formed a closed loop control and have controlled system, ensured the stability of the curative effect of therapeutic instrument, improved the obvious effective rate of treatment, make it to have safety, reliable, have no side effect, painless, can act on advantage such as deep nervous tissue, this is that electrical acupuncture method can't be compared.Using of this instrument will be opened up a new way as the treatment of nervous system brain diseases.
Therapy device for curing brain disease with brain wave information feedback of the present invention is made up of the hardware and software two large divisions.Hardware components comprises: EEG signals amplifilter 1, A/D change-over panel 2, micro-mainframe computer 3, and graphical display 4, floppy disk 5, hard disk drive 6, keyboard 7, speaker 8, D/A change-over panel 9, electromagnetic stimulation device 10.
A/D change-over panel and D/A change-over panel all are plugged in the expansion slot of microcomputer main frame.EEG signals amplifilter 1 comprises the band-pass circuit of 0.5Hz-300Hz and the double T active filter circuit of 50Hz trap.This part circuit can be made circuit board and insert in the microcomputer host expansion slot.
Micro-mainframe computer 3 can be furnished with a floating-point operation coprocessor, thereby has improved the arithmetic speed of microcomputer greatly, has strengthened the real-time of feedback treating.
Therapeutic instrument job step of the present invention is as follows:
(1) adopt the EEG signals of frontal region to carry out the filtering amplification, input microcomputer after the A/D conversion; (2) carry out brain electric data collecting and analysis after the microcomputer initialization, and carry out brain electricity feedback control in real time according to analysis result; (3) the control signal part input speaker of microcomputer output sends the prompting sound signal, carries out biofeedback; Another part is then through D/A conversion back input electromagnetic stimulation device, adjusts the intensity, frequency and the variation in time that place the electromagnetic field that the patient head solenoid produced, carries out magnetic therapy; (4) treatment finishes, and CRT shows therapeutic process midbrain electricity index curve; (5) end-of-job.
Description of drawings of the present invention is as follows:
Fig. 1 is the inventive principle block diagram, and wherein, B is patient's head, 1. EEG signals amplification filtering plate, 2.A/D change-over panel, 3. micro-mainframe computer, 4. display, 5. floppy disk, 6. hard disk drive, 7. keyboard, 8. speaker, 9.D/A change-over panel, 10. electromagnetic stimulation device.
Fig. 2 is a hardware configuration schematic block diagram of the present invention, wherein, C is that band display, soft or hard are twoly driven, the microcomputer of keyboard, speaker, 1,2,9,10 is respectively EEG signals amplification filtering plate, A/D change-over panel, D/A change-over panel, the electromagnetic stimulation device that inserts in the motherboard expansion slot among the figure, the L solenoid.
Fig. 3 is an EEG signals amplifying filter circuit schematic diagram of the present invention, wherein, A1-A3. integrated operational amplifier, R1-R6. resistance, C1-C5. electric capacity, the circuit of compositions such as A1, A2 and R1-R3, C1-C2 is the logical amplifilter of 0.5-300Hz band, and the circuit that A3 and R4-R6, C3-C5 form is a 50Hz double T active trap; I, o are respectively input, outfan.
Fig. 4 is electromagnetic stimulation device circuit theory diagrams of the present invention.Wherein, R7. resistance, the Rw variable resistance, C6-C11. electric capacity, L. solenoid, LA4422 are integrated power amplifiers, 1.-10. are the wiring foot.
Fig. 5 is a computer software general flow chart of the present invention, wherein, 11. software opens the beginning, 12. the initialize routine module, 13. brain electric data collectings and analysis module, 14. brains electricity feedback control module, 15. treatment time arrives? Y. the time is to continuing next program, N. otherwise be reverse back to program after the initialization, the 16.CRT display module, 17. finish.
Fig. 6 is a computer software initialize routine module flow chart of the present invention, wherein, 18. set up the used cosine table of fast Fourier transform, 19. set up D/A output control waveform table, 20. the input date, 21. input patient's name, age, sex and numbering, 22. set up files according to numbering, and 23. calculate triumphant damp window function.
Fig. 7 is computer software brain electric data collecting of the present invention and analysis module flow chart, and wherein, 24. are provided with A/D interrupts and start A/D interrupting, and carries out the EEG signals sampling; 25. waiting for sampling finishes; 26. judge that sampling finishes? Y. be, continue next program, N. does not continue to wait for; 27. sampled data Jia Kaize window is handled and is carried out fast Fourier transform; 28. judge that the electroencephalogramsignal signal analyzing number of times reaches requirement? Y. be, continue next program, N. does not return 25 to be continued to wait for; 29. closing sampling interrupts; 30. calculate brain electricity index I
a, brain electricity main peak Fm and brain electricity coherent function Coh.
Fig. 8 is a computer software brain electricity feedback control module flow chart of the present invention.Wherein, 31. calculating target functions, I=I
a+ Coh; 32. judge whether to be brain electric control first? Y. be, continue next program 33, N. does not continue next program 36; 33. whether is artifact serious to judge the EEG signals of being gathered? Y. be, continue next program 34, N. does not continue next program 35; 34. computer provides a feedback frequency signal scope automatically; 35. calculate the feedback frequency signal scope according to analysis result; Whether artifact is serious 36. judge the EEG signals gathered, and Y. is, continues next program 38, and N. does not continue next program 37; 37. with 35; 38. with 34; 39. judge the good of patient's brain electrical acti index, I [K] 〉=I [K-1] with poor? Y. be, continue next program 41, N. does not continue next program 40; 40. long sound prompting; Interrupt being provided with 41. carry out D/A, start D/A and interrupt; 42. carry out the brain electric information feedback treating; 43. treatment time arrives, and closes D/A and interrupts.
Fig. 9 is a computer software CRT display module flow chart of the present invention.Wherein, 44.CRT shows brain electricity directive function menu; 45. keying in number selects; 46. judge whether to finish treatment? Y. be, change termination routine 17, N. does not continue next program; 47. show corresponding brain electricity index curve, show the program of getting back to 44 that finishes.
The invention will be further described below in conjunction with description of drawings.
EEG signals amplification filtering plate schematic diagram is seen Fig. 3, and its task is to receive to amplify EEG signals.
Electroencephalogramsignal signal analyzing and feedback fraction are born by A/D change-over panel and master microcomputer, and configurable coprocessor on the machine carries out floating-point operation. This part is finished electroencephalogramsignal signal analyzing, and corresponding control signal is sent in the decision-making of feedback treating scheme.
The feedback operating part is made up of D/A change-over panel, loudspeaker and electromagnetic stimulation device. ((0～10Gs) signal, coil place on patient head diseased region and the relevant acupuncture point 8～30Hz) weak magnetic to produce low frequency on the coil. Loudspeaker is for generation of the biofeedback cue, patient directions subjective efforts direction.
The treatment results output, (CRT) bears by display, output brain electricity feedback control procedure brain electricity index curve.
The software of therapeutic equipment mainly is made up of four functional modules, writes with C language and a small amount of assembler language to form.
Respectively each functional module is introduced below:
1. initialization module. DA output control waveform table is used for PC by the Waveform Control of DA change-over panel generation analog signal, the information that figure and music begin as program in the initialization module. Triumphant damp subprogram is used for calculating triumphant damp window function, in order to carry out in the back windowing process. Stimulate acoustic frequency to determine the frequency of loudspeaker sounding.
2. brain electric data collecting and analysis module. Because data acquisition adopts the A/D interrupt mode to carry out, in the gap of sampling, can carry out data analysis and process, the EEG signals that measure after brain electricity pre-processed board, disturb and have obtained inhibition, and can not eliminate fully. In order to reduce the spectrum leakage in the spectrum estimation, the eeg data that sampling is obtained carries out the processing of Jia Kaize window, through fast Fourier transformation (FFT), calculates α index I, the main peak frequency Fm of twice computer and the total coherent function in the α frequency range. Adopt repeatedly sampling, then analysis result is carried out superposition, improve signal to noise ratio.
3. brain electricity real-time feedback control module. This functional module is one of core of whole system software, and Fig. 8 is the flow chart of this module, and brain electricity feedback control idea is achieved in the program in this section, carries out decision-making and concrete execution of brain electricity FEEDBACK CONTROL scheme.
Calculating target function: I=I at firsta+Coh
Wherein, I
aBe brain electricity index (brain electricity alpha rhythm power/brain electricity general power) that Coh is a brain electricity coherent function.
Judge, make a strategic decision according to object function, the decision feedback controling mode.Judge to mainly contain two aspects, at first, whether detected EEG signals is true, and promptly seriously whether artifact.If artifact is serious, eeg data does not add employing, is rejected.Secondly, how in meditation the experimenter is.If in meditation bad, send out sound prompting long so that make patient in addition subjective consciousness regulate, reduce the number of times of prompting sound as far as possible.
After said process is finished, carry out D/A and interrupt being provided with (comprising that output signal frequency scope, intensity and time change) and start the D/A interruption.Treatment finishes then to close D/A and interrupts.
Show 4.CRT display module is finished screen graph, show various therapeutic process midbrain electricity index curves.
Embodiment is shown in Fig. 1-9.Adopt IBM PC/XT main frame, add 8087 coprocessors.EEG signals amplifilter function be in the filtering input signal less than 0.5Hz, equal 50Hz and greater than the interfering signal of 300Hz, and EEG signals is amplified.A
1, A
2, LM324 and element R
1100K Ω, R
2750K Ω, R
368K Ω, C
1620PF, C
2100 μ F constitute 0.5Hz～logical amplifilter of 300Hz band, A
3LM324 and element R
472 Ω, R
520K Ω, R
672 Ω, C
32.2 μ F, C
42.2 μ F, C
54.4 μ F constitutes 50Hz double T active trap.Adopt 1232 type A/D change-over panels and 1612 type D/A change-over panels, display, keyboard, two the driving all of soft or hard get final product with the existing model that matches with main frame in the prior art.Electromagnetic stimulation device schematic diagram as shown in Figure 4, power amplifier LA4422 wherein, R
710K Ω, Rw 200K Ω, C
6100 μ F, C
7200 μ F, C
8100 μ F, C
9470 μ F, C
101000 μ F, C
110.15 μ F, solenoid L makes hat type, is convenient to patient's head is applied magnetic therapy.The software program of present embodiment is shown in Fig. 5-9.Sampled point 256, sample frequency 128Hz, the twice EEG signals is taken from two of F3, F4 and is led.
The present invention shows that through clinical application research nervous system brain diseases such as cerebrovascular disease, encephalatrophy, craniocerebral trauma (cerebral concussion, slight cerebral contusion, combined external head injuries), antimigraine, epilepsy, facial spasm are had significant curative effect, does not find side reaction during the treatment. This invention treatment brain diseases have produce effects fast, safe, painless, have no side effect, can act on the advantage such as deep nerve tissue, clinical research thinks that this therapeutic equipment also has the function of prevention, health care except treatment, be widely used in all kinds of medical health departments, have wide popularizing application prospect.
Claims (8)
1, therapy device for curing brain disease with brain wave information feedback, comprise eeg signal acquisition amplifier section, electroencephalogramsignal signal analyzing and feedback fraction, feedback and operating part, therapeutic outcome output, it is characterized in that, brain electric information gather amplifier section be by in the filtering input signal less than 0.5Hz, equal 50Hz, greater than the EEG signals amplifilter of 300Hz interfering signal; Electroencephalogramsignal signal analyzing and feedback fraction are made of A/D change-over panel and band speaker, keyboard, the two microcomputer main frames that drive peripheral hardware of soft or hard; Feedback and operating part are made up of D/A change-over panel, speaker and electromagnetic stimulation device; More than each wiring board all be plugged in the microcomputer host expansion slot, the solenoid of electromagnetic stimulation device places outside the main frame, the electromagnetic field frequency of electromagnetic stimulation device is 8-30Hz, intensity 0-10GS; Said solenoid is the hat type solenoid, directly acts on patient's head.
2, therapy device for curing brain disease with brain wave information feedback as claimed in claim 1, it is characterized in that the EEG signals amplifilter comprises that the 0.5Hz-300Hz band that is made of A1 LM324, A2 LM324 integrated transporting discharging and element R1 100K Ω, R2 50K Ω, R3 68K Ω, C1 620PF, C2 100 μ F leads to the 50Hz double T active trap that amplifilter and A3 LM324 and R4 72 Ω, R5 20K Ω, R6 72 Ω, C3 2.2 μ F, C4 2.2 μ F, C5 4.4 μ F constitute; Input signal send (-) input of integrated transporting discharging A1 through resistance R 1, between A1 (-) end and outfan and meet R2, C, connect (-) end of A2 after C2 and R3 joined, another termination A1 outfan of R3, A1(+) end meets C2 after joining with the A2 outfan, A2(+) end ground connection, after joining, C3 and R4 connect the A1 outfan, C3 and C4 join after resistance R 6 is joined with A3 outfan and (-) end, R4 and R5 join after capacitor C 5 ground connection, connect (+) end of A3 after C4 and R5 join, the input of the output termination A/D change-over panel of A3 all; Wherein integrated transporting discharging A1, A2, A3 can be integrated on a slice integrated circuit as LM324.
3, therapy device for curing brain disease with brain wave information feedback as claimed in claim 1, it is characterized in that the electromagnetic stimulation device is made of LA4422 integrated power amplifier and element R7 10K Ω, Rw 200K Ω, C8 100 μ F, C9 200 μ F, C10 1000 μ F, C11 0.15 μ F and solenoid; The outfan of resistance R 7 one termination D/A change-over panels, the other end and potentiometer Rw join, the center sub of Rw connects the 2. foot of LA4422, with 8. foot, C11, the L back ground connection of joining of Rw and C6, C7, LA4422 the, LA4422 1. foot connects power supply, and power supply and ground is capacitor C 9 indirectly, LA4422 7., the 10. indirect capacitor C 8 of foot, output capacitance C10 one end and LA4422 10. foot join, another termination capacitor C 11 and solenoid L.
4, a kind of method of work as the said brain electric information feedback of claim 1 brain portion disease therapeutic equipment is characterized in that the therapeutic instrument job step is as follows:
(1) EEG signals of picking up from the frontal region is carried out the filtering amplification, input microcomputer after the A/D conversion;
(2) carry out brain electric data collecting and analysis after the microcomputer initialization, and carry out brain electricity feedback in real time according to analysis result;
(3) microcomputer input signal part input speaker sends the announcement acoustical signal, carry out biofeedback, another part then places the electromagnetic field intensity that solenoid produced, frequency and the variation in time of patient's head to carry out magnetic therapy through the adjustment of D/A conversion back input electromagnetic stimulation device;
(4) treatment finishes, and CRT shows therapeutic process midbrain electricity index curve;
(5) finish.
5, method of work as claimed in claim 4 is characterized in that, said microcomputer initialization adopts following steps to carry out:
(1) sets up the used cosine table of fast Fourier transform;
(2) set up D/A input control waveform table;
(3) the input date;
(4) input patient's name, age, sex and numbering;
(5) set up files according to numbering;
(6) calculate triumphant damp window function.
6, method of work as claimed in claim 4 is characterized in that, said microcomputer brain electric data collecting and analytical work step are as follows:
(1) A/D is set and interrupts and start A/D interrupting, carry out the EEG signals sampling;
(2) wait for that sampling finishes;
(3) do you judge that sampling finishes? be to continue next program; , do not continue to wait for;
(4) sampled data Jia Kaize window is handled and carried out fast Fourier transform;
(5) do you judge that the electroencephalogramsignal signal analyzing number of times reaches requirement? be to continue next program; , do not return and wait for that sampling finishes;
(6) closing sampling interrupts;
(7) calculate brain electricity index I α, brain electricity main peak frequency Fm and brain electricity coherent function Coh.
7, method of work as claimed in claim 4 is characterized in that, said brain electricity feedback control is in real time undertaken by follow procedure:
(1) calculating target function, I=I α+Coh;
(2) judge whether to be brain electric control first?
Be 1. that whether artifact is serious to continue to judge the EEG signals of being gathered? be, then computer provides a frequency range automatically, carries out next step; Not, then calculate the feedback frequency signal scope, carry out next step according to analysis result;
2. deny that whether artifact is serious to continue to judge the EEG signals of being gathered? be, then computer provides a frequency range automatically, carries out next step; Not, then calculate the feedback frequency signal scope according to analysis result, continuation judgement patient's brain electrical acti index is good and poor then? be, then carry out next step, not, then long sound prompting is carried out next step;
(3) carry out D/A and interrupt being provided with, start D/A and interrupt;
(4) carry out the brain electric information feedback treating;
(5) treatment time arrives, and closes D/A and interrupts.
8, method of work as claimed in claim 4 is characterized in that, said CRT demonstration comprises follow procedure:
(1) CRT shows brain electricity directive function menu;
(2) keying in number selects;
(3) judge whether to finish treatment? be to finish; , then do not continue next step;
(4) show corresponding brain electricity index curve;
(5) show to finish and return (1).
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| CN 93115236 CN1029294C (en) | 1993-11-24 | 1993-11-24 | Therapy device for curing brain disease with brain wave information feedback |
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| CN 93115236 CN1029294C (en) | 1993-11-24 | 1993-11-24 | Therapy device for curing brain disease with brain wave information feedback |
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| CN1029294C true CN1029294C (en) | 1995-07-12 |
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|---|---|---|---|---|
| JP3581319B2 (en) * | 2000-12-18 | 2004-10-27 | 株式会社脳機能研究所 | Brain activity automatic judgment device |
| ES2951766T3 (en) * | 2009-07-08 | 2023-10-24 | Neuromodtronic Gmbh | Electrical stimulation device to treat the human body |
| US11730970B2 (en) | 2013-03-14 | 2023-08-22 | The Methodist Hospital | Method and apparatus for providing transcranial magnetic stimulation (TMS) to an individual |
| CN103394161A (en) * | 2013-07-16 | 2013-11-20 | 山西大学 | Cerebral alpha wave feedback regulation acupoint magnetic stimulation system |
| EP3033007B1 (en) * | 2013-08-15 | 2019-10-23 | The Methodist Hospital | Apparatus for providing transcranial magnetic stimulation (tms) to an individual |
| CN106964069B (en) * | 2017-03-23 | 2020-12-29 | 秦皇岛市惠斯安普医学系统股份有限公司 | Microcirculation repair system with biofeedback function |
| CN112244837B (en) * | 2020-07-27 | 2024-06-07 | 长春中医药大学附属医院(吉林省中医院) | Traditional Chinese medicine therapeutic instrument for treating memory loss encephalopathy |
| CN113476060B (en) * | 2021-06-16 | 2024-03-08 | 南京曦光信息科技研究院有限公司 | Closed-loop feedback type photoacoustic and electromagnetic integrated brain work rhythm adjusting device |
-
1993
- 1993-11-24 CN CN 93115236 patent/CN1029294C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1089513A (en) | 1994-07-20 |
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