CN102772396B - Cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals - Google Patents
Cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals Download PDFInfo
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- CN102772396B CN102772396B CN 201210259183 CN201210259183A CN102772396B CN 102772396 B CN102772396 B CN 102772396B CN 201210259183 CN201210259183 CN 201210259183 CN 201210259183 A CN201210259183 A CN 201210259183A CN 102772396 B CN102772396 B CN 102772396B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 241001465754 Metazoa Species 0.000 title claims abstract description 13
- 230000001954 sterilising effect Effects 0.000 title abstract description 12
- 238000004140 cleaning Methods 0.000 title abstract description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 23
- 239000007921 spray Substances 0.000 claims abstract description 23
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract description 21
- 229960002233 benzalkonium bromide Drugs 0.000 claims abstract description 17
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 229920001213 Polysorbate 20 Polymers 0.000 claims abstract description 12
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims abstract description 12
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims abstract description 12
- 229940068977 polysorbate 20 Drugs 0.000 claims abstract description 12
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 claims abstract description 10
- 229960002152 chlorhexidine acetate Drugs 0.000 claims abstract description 9
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims abstract description 8
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims abstract description 8
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
- 239000008213 purified water Substances 0.000 claims description 32
- 238000003756 stirring Methods 0.000 claims description 30
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 27
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 239000012459 cleaning agent Substances 0.000 claims description 22
- 238000001914 filtration Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 230000000845 anti-microbial effect Effects 0.000 claims description 8
- 230000003115 biocidal effect Effects 0.000 claims description 6
- 229960004106 citric acid Drugs 0.000 claims description 6
- ONLRKTIYOMZEJM-UHFFFAOYSA-N n-methylmethanamine oxide Chemical compound C[NH+](C)[O-] ONLRKTIYOMZEJM-UHFFFAOYSA-N 0.000 claims description 6
- 238000012856 packing Methods 0.000 claims description 5
- 229960001716 benzalkonium Drugs 0.000 claims description 2
- -1 benzalkonium bromides Chemical class 0.000 claims description 2
- 241000282472 Canis lupus familiaris Species 0.000 abstract description 7
- 241000282326 Felis catus Species 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract description 2
- 206010072170 Skin wound Diseases 0.000 abstract description 2
- 238000011282 treatment Methods 0.000 abstract description 2
- 229960003260 chlorhexidine Drugs 0.000 abstract 2
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 abstract 1
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 description 13
- 206010052428 Wound Diseases 0.000 description 11
- 208000027418 Wounds and injury Diseases 0.000 description 11
- 238000004659 sterilization and disinfection Methods 0.000 description 10
- 239000007788 liquid Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 239000006228 supernatant Substances 0.000 description 6
- 239000003093 cationic surfactant Substances 0.000 description 5
- 230000000249 desinfective effect Effects 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 210000004877 mucosa Anatomy 0.000 description 4
- 206010002515 Animal bite Diseases 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010037742 Rabies Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 238000006748 scratching Methods 0.000 description 2
- 230000002393 scratching effect Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010051548 Burn infection Diseases 0.000 description 1
- 241000288673 Chiroptera Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010015866 Extravasation Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- AHOFBTVTMYSTSR-UHFFFAOYSA-N OCN1C(NC(C1(CO)N(C(=O)NCO)CO)=O)=O.C(C)O Chemical compound OCN1C(NC(C1(CO)N(C(=O)NCO)CO)=O)=O.C(C)O AHOFBTVTMYSTSR-UHFFFAOYSA-N 0.000 description 1
- 229920000153 Povidone-iodine Polymers 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 229940001468 citrate Drugs 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000036251 extravasation Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000017 mucous membrane irritation Toxicity 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002064 post-exposure prophylaxis Effects 0.000 description 1
- 229960001621 povidone-iodine Drugs 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- LACQPOBCQQPVIT-SEYKEWMNSA-N scopolamine hydrobromide trihydrate Chemical compound O.O.O.Br.C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 LACQPOBCQQPVIT-SEYKEWMNSA-N 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals. The purpose of the invention is to provide a cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals with the characteristics of simple preparation, good stability, ease use and good use effect. The technical solution provided by the invention is as follows: the cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals is characterized in that the combination type preparation comprises a weakly alkaline cleaner and a skin antibacterial spray; the raw materials of the weakly alkaline cleaner include benzalkonium chloride or benzalkonium bromide, 30% dodecyl dimethyl amine oxide solution and polysorbate 20; the raw materials of the skin antibacterial spray include benzalkonium bromide, or benzalkonium chloride, or chlorhexidine, or chlorhexidine acetate, or chlorhexidine hydrochloride, or chlorhexidine citrate, or 20% chlorhexidine gluconate solution and polysorbate 20. The preparation provided by the invention is applied to the treatments of cleaning and sterilizing the skin wounds after being bitten or scratched by dogs, cats and other animals.
Description
Technical field
The present invention relates to a kind of clean antibiotic preparation, especially a kind ofly for animal, grab the combined preparation that the rear skin clean that bites is antibiotic and be used in conjunction with.Be applicable to the animal bites such as dog, cat, the skin wound after scratching cleanly cleans, disinfecting, antimicrobial is processed.
Background technology
As accidentally by mad dog, doubtful mad dog or can not determine that healthy rabies host animal (as mammals such as Canis familiaris L., cat, bat bats) bites, scratches, licks and lick mucosa or damaged skin place, very large causing a disease or even fatal danger may be arranged, must not be careless, must process rapidly.Can not determine that so all the animal of hurting sb.'s feelings is healthy animal, according to World Health Organization's guideline, should carry out wound clean at once and use disinfecting, antimicrobial liquid to process, then will go to institute of professional medical mechanism to send for a doctor to process as soon as possible.
By Ministry of Public Health prevention and control of diseases office " rabies post-exposure prophylaxis flow chart " requirement, at present commercially available prod has two kinds of methods 1. to use suds (or other alkalescence cleaning agent) and mobile clear water (or normal saline) alternately to clean a wound at least 15 minutes to the processing of wound, then uses povidone iodine (or iodine tincture, ethanol) sterilization wound.2. use suds (or other alkalescence cleaning agent) and mobile clear water (or normal saline) alternately to clean a wound at least 15 minutes, then with other disinfection antibacterial agent sterilization wounds.Commercially available disinfection antibacterial agent commonly used is generally the cationic surfactants such as hibitane class (hibitane class), strand or double-chain quaternary ammonium salt class.
Yet there is following problem in above-mentioned processing method: the iodine tincture in first method, ethanol Diazolidinyl Urea mucosa and produce violent pain when the skin of damaged wound is arranged.Suds commonly used in second method are anion surfactant, neutralization can occur when the cationic surfactant in disinfection antibacterial agent runs into anion surfactant should, so that the curative effect of disinfection antibacterial agent reduces even inefficacy, particularly, when the suds cleaning is thorough and Local residues is arranged, this situation more easily occurs.
Summary of the invention
The technical problem to be solved in the present invention is: for the problem of above-mentioned existence, provide a kind of and prepare easy, good stability, easy to use and result of use is good for animal, grabs the combined preparation that the rear skin clean that bites is antibiotic and be used in conjunction with, reduce to skin and mucous membrane irritation the problem of avoiding the zwitterion neutralization to cause the disinfecting, antimicrobial effect to reduce or lost efficacy.
The technical solution adopted in the present invention is: grab for animal the combined preparation that the rear skin clean that bites is antibiotic and be used in conjunction with, it is characterized in that this combined preparation comprises alkalescence cleaning agent and antibacterial skin spray:
1.1 the alkalescence cleaning agent be used in conjunction with the antibacterial skin spray, raw material comprises benzalkonium chloride or benzalkonium bromide, 30% dodecayl dimethyl amine oxide solution and polysorbate 20, be by ratio of weight and the number of copies: 1.5～2.5 parts of benzalkonium chloride or benzalkonium bromides, 30% 2.5～3.5 parts of dodecayl dimethyl amine oxide solution, 0.5～1.5 part of polysorbate 20;
1.2 the preparation technology of described alkalescence cleaning agent is:
Add in 60 ℃ of appropriate purified water 1.2.1 take in proportion benzalkonium chloride or benzalkonium bromide, fully stir and make it to dissolve fully, obtain solution 1;
1.2.2 add 60% purified water of full dose in preparing tank, add all the other raw materials of formula, stirring and dissolving, obtain solution 2;
1.2.3 solution 1 is added in preparing tank, add purified water and be settled to full dose, stirring and evenly mixing, obtain intermediate;
1.2.4 detect character, pH value, the content of intermediate;
1.2.5 filtration, fill;
1.3 the antibacterial skin spray be used in conjunction with the alkalescence cleaning agent, raw material comprises chlorhexidine gluconate solution and the polysorbate 20 of benzalkonium bromide or benzalkonium chloride, hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane or 20%, be by ratio of weight and the number of copies: 0.5～1.5 part of benzalkonium bromide or benzalkonium chloride, 20～30 parts of 3～7 parts of hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane or 20% chlorhexidine gluconate solution, 1～3 part of polysorbate 20;
1.4 the preparation technology of described antibacterial skin spray is:
1.4.1 take benzalkonium bromide or benzalkonium chloride adds in 60 ℃ of appropriate purified water by formula, fully stir and make it to dissolve fully, obtain solution 1;
1.4.2 add 60% purified water of full dose in preparing tank, add all the other raw materials of formula, stirring and dissolving, obtain solution 2;
1.4.3 solution 1 is added in preparing tank, add purified water and be settled to full dose, stirring and evenly mixing, obtain intermediate;
1.4.4 detect character, pH value, the content of intermediate;
1.4.5 filtration, fill;
1.5 the alkalescence cleaning agent of fill and antibacterial skin spray are placed in same packing box respectively.
The HCl or the NaOH that also comprise 0.01mol/L in the formula of step 1.1 and step 1.3, regulate alkalescence cleaning agent pH value to 6.5～9.0, regulation of skin antimicrobial spray pH value to 5.5～8.5.
The invention has the beneficial effects as follows: alkalescence cleaning agent of the present invention and antibacterial skin spray prepare easy, good stability, easy to use and the animal bites such as dog, cat, scratch etc. are had to good disinfecting, antimicrobial effect, to mucocutaneous non-stimulated, can not produce zwitterion neutralization and answer and the reduction drug effect.After pH value regulator (HCl of 0.01mol/L or NaOH solution) is regulated, alkalescence cleaning agent and antibacterial skin spray can, at steady quality in room temperature storage 24 months, can store for a long time.
The specific embodiment
Embodiment 1:
1. prepare the alkalescence cleaning agent
1, component:
2, processing step:
(1) benzalkonium chloride of getting in component adds in 60 ℃ of appropriate purified water, fully stirs and makes it to dissolve fully, obtains solution 1;
(2) add the purified water of full dose 60% in preparing tank again, add all the other raw materials in component, stirring and dissolving, obtain solution 2;
(3) solution 1 is added in preparing tank, adds purified water and be settled to 1000ml, stirring and evenly mixing, obtain intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and adds the HCl of 0.01mol/L or NaOH solution to regulate in pH value to 6.5～9.0 scopes;
(5) filtration, fill.
2. prepare the antibacterial skin spray
1, component:
2, processing step:
(1) benzalkonium bromide of getting in component adds in 60 ℃ of appropriate purified water, fully stirs and makes it to dissolve fully, obtains solution 1;
(2) add the purified water of full dose 60% in preparing tank, add all the other raw materials in component, stirring and dissolving, obtain solution 2;
(3) solution 1 is added in preparing tank, adds purified water and be settled to 1000ml, stirring and evenly mixing, obtain intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and adds the HCl of 0.01mol/L or NaOH solution to regulate in pH value to 5.5～8.5 scopes;
(5) filtration, fill.
Also available chlorhexidine acetate or chlorhexidine hydrochloride or the replacement of citric acid hibitane of hibitane in said components.
Finally the alkalescence cleaning agent of fill and antibacterial skin spray are placed in same packing box respectively, warehouse-in.The animal bite such as dog, cat, be used in conjunction with this combined preparation after scratching, in time to wound clean cleaning, disinfecting, antimicrobial is processed.
Embodiment 2:
1. prepare the alkalescence cleaning agent
1, component:
2, processing step:
(1) benzalkonium bromide of getting recipe quantity adds in 60 ℃ of purified water, fully stirs and makes it to dissolve fully, obtains solution 1;
(2) add the purified water of full dose 60% in preparing tank, add all the other raw materials in component, stirring and dissolving, obtain solution 2;
(3) solution 1 is added in preparing tank, add purified water and be settled to 1000ml, stirring and evenly mixing, obtain intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and adds the HCl of 0.01mol/L or NaOH solution to regulate in pH value to 6.5～9.0 scopes;
(5) filtration, fill.
2. prepare the antibacterial skin spray
1, component:
2, processing step:
(1) benzalkonium chloride of getting in component adds in 60 ℃ of purified water, fully stirs and makes it to dissolve fully, obtains solution 1;
(2) add the purified water of full dose 60% in preparing tank, add all the other raw materials in component, stirring and dissolving, obtain solution 2;
(3) solution 1 is added in preparing tank, add purified water and be settled to 1000ml, stirring and evenly mixing, obtain intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and adds the HCl of 0.01mol/L or NaOH solution to regulate in pH value to 5.5～8.5 scopes;
(5) filtration, fill.
Finally the alkalescence cleaning agent of fill and antibacterial skin spray are placed in same packing box respectively, warehouse-in.
Embodiment 3:
1. prepare the alkalescence cleaning agent
1, component:
2, processing step:
(1) benzalkonium chloride of getting in component adds in 60 ℃ of purified water, fully stirs and makes it to dissolve fully, obtains solution 1;
(2) add the purified water of full dose 60% in preparing tank, add all the other raw materials in component, stirring and dissolving, obtain solution 2;
(3) solution 1 is added in preparing tank, add purified water and be settled to 1000ml, stirring and evenly mixing, obtain intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and adds the HCl of 0.01mol/L or NaOH solution to regulate in pH value to 6.5～9.0 scopes;
(5) filtration, fill.
2. prepare the antibacterial skin spray
1, prescription:
2, processing step:
(1) benzalkonium chloride of getting in component adds in 60 ℃ of purified water, fully stirs and makes it to dissolve fully, obtains solution 1;
(2) add the purified water of full dose 60% in preparing tank, add all the other raw materials in component, stirring and dissolving, obtain solution 2;
(3) solution 1 is added in preparing tank, add purified water and be settled to 1000ml, stirring and evenly mixing, obtain intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and adds the HCl of 0.01mol/L or NaOH solution to regulate in pH value to 5.5～8.5 scopes;
(5) filtration, fill.
Finally the alkalescence cleaning agent of fill and antibacterial skin spray are placed in same packing box respectively, warehouse-in.
In above-described embodiment, the cationic surfactant prepared in the antibacterial skin spray can also be chlorhexidine hydrochloride or citric acid hibitane.
In above-described embodiment, described benzalkonium chloride, benzalkonium bromide, dodecayl dimethyl amine oxide, hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane or chlorhexidine gluconate, polysorbate 20 and purified water are commercially available prod.
Benzalkonium chloride another name benzalkonium chloride, benzalkonium bromide another name benzalkonium bromide, both are cationic surfactant class wide-spectrum bactericide, can change antibacterial endochylema membrane permeability, make thalline endochylema extravasation, hinder its metabolism and play killing action, stronger to the gram-positive bacteria effect, be usually used in the treatment of cleaning and sterilizing, wound and the burn infection of skin and mucosa and wound, sterilization and the preservation of operating theater instruments tool.
Hibitane or chlorhexidine acetate or chlorhexidine gluconate or chlorhexidine hydrochloride or citric acid hibitane, their corresponding another names are respectively hibitane, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, citrate hibitane, five kinds of hibitane are cationic surfactant, broad-spectrum sterilization, bacteriostasis are arranged, and antimicrobial spectrum comprises Grain-positive and negative bacterium, fungus and some virus.After it is adsorbed in cell wall, change its surface texture and Osmotic balance, endochylema composition seepage, can make endochylema solidify during high concentration, suppressed the reparation of cell wall, and this model of action is difficult for producing drug resistance, for hands, skin, mucosa, wound surface and sterilization of instruments.
The water that purified water H2O18.02 this product is the hyoscine that makes through the way of distillation, ion exchange, hyperfiltration or other suitable methods of drinking water, containing any additive.
Dodecayl dimethyl amine oxide, commodity are called OA-12, OB-2, being a kind of amphoteric surfactant, is colourless transparent liquid, is cationic in acid medium, be nonionic in alkaline medium, the foam that tool is good and detergency ability, also have the characteristics such as sterilization and easily biological-degradable.
Polysorbate 20, the another name polysorbas20, be nonionic surfactant, has emulsifying and hydrotropy effect.
Claims (2)
1. grab for animal the combined preparation that the rear skin clean that bites is antibiotic and be used in conjunction with, it is characterized in that this combined preparation comprises alkalescence cleaning agent and antibacterial skin spray:
1.1 the alkalescence cleaning agent be used in conjunction with the antibacterial skin spray, raw material comprises benzalkonium chloride or benzalkonium bromide, 30% dodecayl dimethyl amine oxide solution and polysorbate 20, be by ratio of weight and the number of copies: 1.5 ~ 2.5 parts of benzalkonium chloride or benzalkonium bromides, 30% 2.5 ~ 3.5 parts of dodecayl dimethyl amine oxide solution, 0.5 ~ 1.5 part of polysorbate 20;
1.2 the preparation technology of described alkalescence cleaning agent is:
Add in 60 ℃ of appropriate purified water 1.2.1 take in proportion benzalkonium chloride or benzalkonium bromide, fully stir and make it to dissolve fully, obtain solution 1;
1.2.2 add 60% purified water of full dose in preparing tank, add all the other raw materials of formula, stirring and dissolving, obtain solution 2;
1.2.3 solution 1 is added in preparing tank, add purified water and be settled to full dose, stirring and evenly mixing, obtain intermediate;
1.2.4 detect character, pH value, the content of intermediate;
1.2.5 filtration, fill;
1.3 the antibacterial skin spray be used in conjunction with the alkalescence cleaning agent, raw material comprises chlorhexidine gluconate solution and the polysorbate 20 of benzalkonium bromide or benzalkonium chloride, hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane or 20%, be by ratio of weight and the number of copies: 0.5 ~ 1.5 part of benzalkonium bromide or benzalkonium chloride, 20 ~ 30 parts of 3 ~ 7 parts of hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane or 20% chlorhexidine gluconate solution, 1 ~ 3 part of polysorbate 20;
1.4 the preparation technology of described antibacterial skin spray is:
1.4.1 take benzalkonium bromide or benzalkonium chloride adds in 60 ℃ of appropriate purified water by formula, fully stir and make it to dissolve fully, obtain solution 1;
1.4.2 add 60% purified water of full dose in preparing tank, add all the other raw materials of formula, stirring and dissolving, obtain solution 2;
1.4.3 solution 1 is added in preparing tank, add purified water and be settled to full dose, stirring and evenly mixing, obtain intermediate;
1.4.4 detect character, pH value, the content of intermediate;
1.4.5 filtration, fill;
1.5 the alkalescence cleaning agent of fill and antibacterial skin spray are placed in same packing box respectively.
2. combined preparation according to claim 1, is characterized in that: also comprise HCl or the NaOH of 0.01mol/L in the formula of step 1.1 and step 1.3, regulate alkalescence cleaning agent pH value to 6.5 ~ 9.0, regulation of skin antimicrobial spray pH value to 5.5 ~ 8.5.
Priority Applications (1)
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| CN104188848B (en) * | 2014-08-06 | 2017-01-18 | 杭州普瑞美克生物科技有限公司 | Cooperatively used combined bag for cleaning and disinfecting skin after dog and animal injuries |
| CN104958283A (en) * | 2015-06-02 | 2015-10-07 | 北京盛大康成医疗技术有限公司 | Alkalescence skin mucosa cleaning and disinfecting composition and preparing method and application thereof |
| US9403702B1 (en) * | 2015-06-13 | 2016-08-02 | A Better Life Worldwide, Llc | Commodity water purifier |
| CN107789209A (en) * | 2017-11-01 | 2018-03-13 | 上海展艺商贸有限公司 | Alkaline electrolyte water antimicrobial fluid and antibacterial wet tissue |
| CN109157646A (en) * | 2018-10-10 | 2019-01-08 | 杭州普瑞美克生物科技有限公司 | The preparation method of the clean negative antimicrobial spray of the stream of people and combined preparation |
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| CN1327382A (en) * | 1998-12-23 | 2001-12-19 | 伊迪亚股份公司 | Improved formulation for topical non-invasive application in vivo |
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