CN107773635A - A kind of animal skin composite disinfectant and preparation method - Google Patents
A kind of animal skin composite disinfectant and preparation method Download PDFInfo
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- CN107773635A CN107773635A CN201610788225.7A CN201610788225A CN107773635A CN 107773635 A CN107773635 A CN 107773635A CN 201610788225 A CN201610788225 A CN 201610788225A CN 107773635 A CN107773635 A CN 107773635A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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Abstract
The present invention relates to a kind of animal skin composite disinfectant, including organosilicon quaternary ammonium salt, chlorhexidine gluconate, Cocoamidopropyl betaine, plant extraction liquid, emollient, ethanol, pH adjusting agent etc..Animal provided by the invention with skin composite disinfectant overcome conventional chemical classes disinfectant excitant it is big the shortcomings that, avoid the injury to skin, organosilicon quaternary ammonium salt is played and the advantages of chlorhexidine gluconate can act synergistically, most common animals skin problems are can solve the problem that using the present invention, it is not likely to produce the resistance to the action of a drug, there are very strong killing bacterium and virus to the animal skin infected, effectively prevent subinfection again.The addition of Cocoamidopropyl betaine and emollient can good cleaning skin.
Description
Technical field
The invention belongs to disinfectant technical field, and in particular to a kind of animal skin composite disinfectant.
Background technology
With the development of health science, popular sterilization it is degerming consciousness it is more and more stronger, particularly experienced " bird flu ",
Epidemic situations such as " hand-foot-and-mouth diseases ", it is found that animal infectious disease and human health are closely bound up, can either there is an urgent need to develop one kind
Efficiently, wide spectrum, quick-acting killing germ body and cans clean animal skin, the disinfectant of bacteria removal residuum while sterilization, directly
Connect and act on animal skin and can be killed removing initial stage to reach animal being contacted with pathogen, then reduce infectious disease
The generation of disease.
Existing animal skin class disinfectant has a lot, mainly has alcohol, Iodophor, hydrogen peroxide, clean youngster to go out, boric acid, height
Potassium manganate and some antibacterial ointment etc., but these disinfectants have certain toxicity and residual, and animal skin is stimulated
Property is bigger, easily causes skin injury.
Organosilicon quaternary ammonium salt is a kind of Novel Cationic Surfactants, is had in terms of sterilization very strong and durable antibiotic
Effect, compared with common quaternary ammonium salt, chemism is stronger, and toxicity is very small, and excitant is also very weak, and is also equipped with good suction
Water absorption of perspiration, flatness, static electricity resistance and resistance tocrocking.The surfactant is non-stimulated to animal skin and carcinogenesis, respectively
Item index all meets the requirement to antiseptic both at home and abroad.
Chlorhexidine gluconate is a kind of biguanides chlorobenzene bactericide of mild, has broad-spectrum sterilization function, does not have to skin
It is irritant, it can be absorbed by the skin completely, but single chlorhexidine gluconate bactericidal effect is not especially desirable, so
A kind of presently disclosed animal skin composite disinfectant, organosilicon quaternary ammonium salt and chlorhexidine gluconate play Synergistic biocidal work
With, while plant extraction liquid and Cocoamidopropyl betaine and emollient are added, can be effective while ensureing to sterilize
Cleaning skin, skin care.
Animal proposed by the present invention smears or is sprayed at quilt that can be quickly on the skin of animal with skin composite disinfectant
Skin absorbs, and germ to skin surface and virus play a part of quickly killing, especially canine these like fighting often
The toy of meeting skin damage, in general common disinfectants is difficult to accomplish to kill germ and virus completely, it is easy to causes skin
Subinfection again, animal proposed by the present invention can kill germ quickly after being sprayed with skin composite disinfectant, promote wound fast
Speed healing prevents from causing the subinfection again of skin, and easy to use, and dog owner necessarily goes to pet clinic oneself at home
It can handle.In addition, mastitis for milk cows is one of disease for causing dairy economic loss most serious, the mankind much exert
Power but still do not reach preferable effect, animal proposed by the present invention can not only kill staphylococcus, chain with skin composite disinfectant
Coccus and Escherichia coli etc. cause the microorganism of mastitis for milk cows and can also effectively protect mammilla of milk cattle, prevent that nipple is dry and cracked,
Suitable for front and rear sterilization of milking, the generation of mastitis for milk cows can be effectively prevented.For the skin of other common animals such as pig, sheep
Sterilization, the present invention also has good effect, and has the characteristics of rapid-curing cutback is disposable, and collocation method is simple, easy to use.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of animal skin composite disinfectant, it is characterised in that
By following weight than bulk drug form：
The organosilicon quaternary ammonium salt is selected from octadecyldimethyl trimethoxysilylpropyl ammonium chloride, polysiloxanes season
One or more kinds of compositions of ammonium salt, hexadecyldimethyl benzyl ammonium trimethoxysilylpropyl ammonium chloride.
The one or more of the emollient in glycerine, glycerine, coco glycerides etc..
The plant extraction liquid is one kind in extract solution from aloe, Flos Lonicerae extractive solution, Radix Sophorae Flavescentis extractive liquid, is aloe or gold
Honeysuckle flower or kuh-seng are prepared through water extract-alcohol precipitation.
The pH adjusting agent is preferably 10% phosphoric acid solution or 20% sodium hydroxide solution；
Methods described step is as follows：
(1) chlorhexidine gluconate is dissolved in ethanol, stirring is to being completely dissolved to obtain solution A；
(2) add organosilicon quaternary ammonium salt to stir to being completely dissolved, obtain solution B；
(3) add Cocoamidopropyl betaine in solution B and emollient is uniformly mixing to obtain solution C；
(4) added in solution C after plant extraction liquid mixes and obtain solution D；
(5) it can obtain that a kind of animal skin provided by the present invention is compound to disappear to 6 to 8 with adjusting pH value after water constant volume
Toxic agent.
(6) a kind of animal provided by the present invention is with skin composite disinfectant usage：Directly smear or be sprayed on skin
Surface is without cleaning.
The beneficial effects of the invention are as follows：
The excitant that animal provided by the invention overcomes conventional chemical classes disinfectant with skin composite disinfectant big lacks
Point, the injury to skin is avoided, all microorganisms can be killed by having played organosilicon quaternary ammonium salt and chlorhexidine gluconate
Advantage, so the present invention can solve the problem that most common animals skin problems, the resistance to the action of a drug is not likely to produce, to the animal skin infected
There are very strong killing bacterium and virus, effectively prevent subinfection again.Cocoamidopropyl betaine and emollient plus
Entering can good cleaning skin.
Embodiment
Embodiment 1
A kind of animal skin composite disinfectant, by following weight than bulk drug form：
Prescription 1：
Preparation method is as follows：
(1) chlorhexidine gluconate is dissolved in ethanol, stirring is to being completely dissolved to obtain solution A；
(2) add octadecyldimethyl trimethoxysilylpropyl ammonium chloride to stir to being completely dissolved, obtain solution
B；
(3) add Cocoamidopropyl betaine in solution B and glycerine is uniformly mixing to obtain solution C；
(4) added in solution C after extract solution from aloe mixes and obtain solution D；
(5) with water constant volume to 1000ml；
(6) it is to obtain a kind of animal provided by the present invention to be answered with skin to adjust pH value to 8 with 20% sodium hydroxide solution
Close disinfectant.
Embodiment 2
Prescription 2：
A kind of animal skin composite disinfectant, specific preparation method are as follows：
(1) chlorhexidine gluconate is dissolved in ethanol, stirring is to being completely dissolved to obtain solution A；
(2) add hexadecyldimethyl benzyl ammonium trimethoxysilylpropyl ammonium chloride to stir to being completely dissolved, obtain solution
B；
(3) add Cocoamidopropyl betaine in solution B and glycerine is uniformly mixing to obtain solution C；
(4) added in solution C after Flos Lonicerae extractive solution mixes and obtain solution D；
(5) with water constant volume to 1000ml；
(6) adjust pH value with 10% phosphoric acid solution and obtain that a kind of animal skin provided by the present invention is compound to disappear to 6
Toxic agent.
Embodiment 3
Prescription 3：
Preparation method is the same as embodiment 1.
Embodiment 4
1st, skin surface bactericidal effect：
The prescription of preferred embodiment 1 prepares disinfectant, is uniformly applied on rabbit skin surface, enters respectively before and after smearing
Row thalline counts, and calculates the disinfectant sterilizing rate.
(1) test method：Swab stick swabs method
Rabbit skin surface is exposed outside, the cotton of sterilizing is soaked in equipped with 4~5 milliliters of sterile saline test tubes
Rod, squeezed on test tube wall and remove unnecessary salt solution, be in several sub-samplings of rabbit skin surface wipes with swab stick, cut off the hand-held of swab stick
End, makes swab stick fall into salt solution test tube, takes back laboratory inspection.Fully shaking test tube, the bacterium washed in lower swab stick.With sterilizing
Syringe draws 1 milliliter of bacterial suspension, is put into and 45~50 DEG C of plain agar test tube is melted and be cooled to equipped with 18~19 milliliters
In, after being sufficiently mixed, it is poured into the plate of sterilizing, or inhale in the empty plate that 1 milliliter of bacterial suspension injection sterilizes, Ran Houqing
Note melts and is cooled to 45~50 DEG C of plain agars, is fully mixed.After plain agar solidification, it is small to put culture 24 in 37 DEG C of incubators
When, count the clump count on flat board.Calculated according to the clump count on flat board and the extension rate of bacterium solution thin in the range of sampling
Bacterium sum.Liquid milliliter number × extension rate in clump count × sampling pipe on total number of bacteria=flat board.
Family's rabbit skin is tested at optional 10, and result of the test is shown in Table 1：
The rabbit skin test results of table 1
As a result show：The average killing rate of the animal skin composite disinfectant is 97.13%, and Disinfection Effect is good.
Embodiment 5
1st, skin surface bactericidal effect：
Disinfectant prepared by the prescription of selection example 2, is uniformly applied on rabbit skin surface, enters respectively before and after smearing
Row thalline counts, and calculates the disinfectant sterilizing rate.
As a result show：The average killing rate of the animal skin composite disinfectant is 98.26%, and Disinfection Effect is good.
Embodiment 6
1st, skin surface bactericidal effect：
The prescription of preferred embodiment 3 prepares disinfectant, is uniformly applied on rabbit skin surface, enters respectively before and after smearing
Row thalline counts, and calculates the disinfectant sterilizing rate.
As a result show：The average killing rate of the animal skin composite disinfectant is 98.31%, and Disinfection Effect is good.
Embodiment 7
1st, Skin Irritation Test
(1) 24h before the test, the hair of 6 family's rabbit back backbone both sides is removed, must not damage skin with hair remover.Go
Hair scope, left and right each about 3cm × 3cm.
(2) next day directly drips the animal of embodiment 1 in one that area is 2.5cm × 2.5cm with skin composite disinfectant
On the unhairing intact skin of side, then covered with one layer of non-stimulated plastic foil or oilpaper, then with non-stimulated immobilization with adhesive tape.Opposite side is gone
Fur skin is as blank control.The application time is 4h.After off-test, it is tested to remove residual with warm water or nonirritant solvent
Thing.
(3) 1h, 24h and 48h observe local skin reaction after tested material is removed, and carry out stimulate the reaction by table 2
Scoring.
The stimulate the reaction grade form of table 2
2. the animal in embodiment 1 is cooked into above-mentioned Skin Irritation Test with skin composite disinfectant, result of the test is shown in Table 3：
The skin irritation test result of table 3
| Rabbit sequence number | Experimental group skin wound repair scores | Control group skin wound repair scores |
| 1 | 0 | 0 |
| 2 | 0 | 0 |
| 3 | 1 | 0 |
| 4 | 0 | 0 |
| 5 | 0 | 0 |
| 6 | 0 | 0 |
(table 3)
As a result show：The scoring of experimental group mean skin stimulate the reaction is 0.17, the scoring of control group mean skin stimulate the reaction
For 0, it follows that the animal in embodiment 1 is very small to animal skin excitant with skin composite disinfectant, to animal skin
There is no any harm.
Embodiment 8
Animal in embodiment 2 is cooked into above-mentioned Skin Irritation Test, experimental group mean skin thorn with skin composite disinfectant
It is 0 to swash reaction scoring, and the scoring of control group mean skin stimulate the reaction is 0, it follows that the animal in embodiment 2 is compound with skin
Disinfectant is very small to animal skin excitant, does not have any harm to animal skin.
Embodiment 9
Animal in embodiment 3 is cooked into above-mentioned Skin Irritation Test, experimental group mean skin thorn with skin composite disinfectant
It is 0.34 to swash reaction scoring, and the scoring of control group mean skin stimulate the reaction is 0, it follows that the animal skin in embodiment 3
Composite disinfectant is very small to animal skin excitant, does not have any harm to animal skin.
Embodiments of the invention are described in detail above, but the content is only presently preferred embodiments of the present invention,
It is not intended to limit the invention.All all any modification, equivalent and improvement done in the application range of the present invention etc., all should
Within protection scope of the present invention.
Claims (2)
- A kind of 1. animal skin composite disinfectant, it is characterised in that by following weight than bulk drug form：The organosilicon quaternary ammonium salt is selected from octadecyldimethyl trimethoxysilylpropyl ammonium chloride, polysiloxanes quaternary ammonium One or more kinds of compositions of salt, hexadecyldimethyl benzyl ammonium trimethoxysilylpropyl ammonium chloride；The emollient is selected from：One or more in glycerine, glycerine, coco glycerides；The pH adjusting agent is 10% phosphoric acid solution or 20% sodium hydroxide solution；The plant extraction liquid is one kind in extract solution from aloe, Flos Lonicerae extractive solution, Radix Sophorae Flavescentis extractive liquid, is aloe or honeysuckle Or kuh-seng is prepared through water extract-alcohol precipitation.
- A kind of 2. preparation method of animal skin composite disinfectant as claimed in claim 1, it is characterised in that methods described Step is as follows：(1) chlorhexidine gluconate is dissolved in ethanol, stirring is to being completely dissolved to obtain solution A；(2) add organosilicon quaternary ammonium salt to stir to being completely dissolved, obtain solution B；(3) add Cocoamidopropyl betaine in solution B and emollient is uniformly mixing to obtain solution C；(4) added in solution C after plant extraction liquid mixes and obtain solution D；(5) it is that can obtain a kind of animal skin composite disinfecting provided by the present invention with pH value is adjusted after water constant volume to 6 to 8 Agent；(6) a kind of animal provided by the present invention is with skin composite disinfectant usage：Directly smear or be sprayed on skin surface Without cleaning.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610788225.7A CN107773635A (en) | 2016-08-31 | 2016-08-31 | A kind of animal skin composite disinfectant and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610788225.7A CN107773635A (en) | 2016-08-31 | 2016-08-31 | A kind of animal skin composite disinfectant and preparation method |
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| CN107773635A true CN107773635A (en) | 2018-03-09 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114010567A (en) * | 2021-10-26 | 2022-02-08 | 江苏天佑医用科技有限公司 | Sustainable sterilization nursing type cow wiping wet tissue and production method thereof |
| CN114631538A (en) * | 2022-04-22 | 2022-06-17 | 中国大熊猫保护研究中心 | Disinfectant for panda colony house, preparation method and disinfection method |
| CN118356383A (en) * | 2024-04-17 | 2024-07-19 | 广州鹰狮化工有限公司 | Pet fur conditioning composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114010567A (en) * | 2021-10-26 | 2022-02-08 | 江苏天佑医用科技有限公司 | Sustainable sterilization nursing type cow wiping wet tissue and production method thereof |
| CN114631538A (en) * | 2022-04-22 | 2022-06-17 | 中国大熊猫保护研究中心 | Disinfectant for panda colony house, preparation method and disinfection method |
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| CN118356383B (en) * | 2024-04-17 | 2024-11-08 | 广州鹰狮化工有限公司 | Fur conditioning composition for pets and preparation method thereof |
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Application publication date: 20180309 |