CN102688401B - Couchgrass root Chinese medicinal oral liquid for treating chronic hepatitis and preparation method thereof - Google Patents

Abstract

The invention discloses a couchgrass root traditional Chinese medicine oral liquid for treating chronic hepatitis, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 90-180 parts of couch grass root, 90-180 parts of oriental wormwood, 30-90 parts of bighead atractylodes rhizome, 30-90 parts of ginger processed pinellia tuber, 30-90 parts of radix bupleuri, 90-180 parts of rehmannia root, 30-90 parts of pseudo-ginseng, 30-90 parts of earthworm and 30-60 parts of liquorice.

Description

Maogen traditional Chinese medicine oral liquid for treating chronic hepatitis and its preparation method

technical field

The invention relates to a traditional Chinese medicine product, in particular to a traditional Chinese medicine oral liquid for treating chronic hepatitis and a preparation method thereof.

Background technique

Chronic hepatitis refers to liver necrosis and inflammation caused by different etiologies, and the course of disease lasts for at least 6 months. Clinically, there may be corresponding symptoms, signs, and abnormal liver biochemical tests, or there may be no obvious clinical symptoms, only liver tissue of necrosis and inflammation. The course of the disease is fluctuating or continuous. Without proper treatment, some patients may progress to liver cirrhosis. Mild to moderate chronic hepatitis: The early symptoms of typical chronic hepatitis are mild and non-specific, fluctuating intermittently, and even without any symptoms for many years. The most common ones are easy fatigue and stomach discomfort, which are easy to be ignored and mistaken for stomach problems; patients with occult liver cirrhosis are often seen clinically. Unknowingly, it gradually develops into liver cirrhosis; occasionally patients experience nausea, abdominal distension, jaundice, and dark urine. Chronic hepatitis is caused by the destruction of liver cells and repeated abnormalities in liver function, resulting in protracted disease or recurrent attacks. At present, there is still a lack of effective treatment methods, which have caused great pain to the patient's physiology and psychology, seriously affected the quality of life of the patient, and threatened the patient's life. The disadvantages of Western medicine in the treatment of chronic hepatitis are the large side effects and great harm to patients. However, Chinese herbal medicine has been recognized by the world as an indispensable and precious treasure house of human medicine. It is extremely important to use traditional Chinese medicine to treat chronic hepatitis. As a channel to be developed, Chinese medicine has the characteristics of mild medicinal properties and wide application range, and has its unique effect in the treatment of chronic hepatitis diseases.

Contents of the invention

The object of the present invention is to provide a long-lasting curative effect, treating both symptoms and root causes, and low-cost Maogen traditional Chinese medicine oral liquid for treating chronic hepatitis and a preparation method thereof.

To achieve the above object, the present invention is achieved through the following technical solutions:

The technical scheme of the present invention is: the Chinese medicine oral liquid for treating chronic hepatitis is prepared from the following Chinese medicine raw materials in parts by weight:

90-180 parts of Chine root, 90-180 parts of Yin Chen, 30-90 parts of Atractylodes macrocephala, 30-90 parts of Jiang Pinellia, 30-90 parts of Bupleurum, 90-180 parts of Rehmannia, 30-90 parts of Panax notoginseng, 30-90 parts of Dilong 30-60 parts of licorice.

The described Chinese medicine oral liquid of Maogen for treating chronic hepatitis is prepared from the following Chinese medicine raw materials in parts by weight:

180 parts of Chinensis, 180 parts of Yinchen, 90 parts of Atractylodes macrocephala, 90 parts of Jiang Pinellia, 90 parts of Bupleurum, 180 parts of Rehmannia, 90 parts of Panax notoginseng, 90 parts of Dilong, 60 parts of Licorice.

The preparation method of described treatment chronic hepatitis Maogen Chinese medicine oral liquid, concrete steps are as follows

Take 180 parts of Chinensis, 180 parts of Yinchen, 90 parts of Atractylodes macrocephala, 90 parts of Jiang Pinellia, 90 parts of Bupleurum, 180 parts of Dihuang, 90 parts of Panax notoginseng, 90 parts of Dilong, 60 parts of licorice, decoct twice with water, each time with water The amount is 8-10 times the weight of the medicinal material, decocted twice, 1-2 hours each time, filtered, the filtrate is concentrated into a clear paste with a relative density of 1.10-1.25 measured at 60-65 ° C, and ethanol is added Stir evenly until the ethanol content is 60%, let it stand for 24 hours, filter, take the filtrate to recover ethanol, concentrate it into an extract containing 65-67% of solid weight, add 20% of sucrose, 12% of refined honey, preservative 1-3%, the stock solution is filled and sealed, sterilized by irradiation, packaged as a finished product, and made into an oral liquid to obtain.

Usage and dosage: take orally, each 20 milliliters of medicine of the present invention, every day 3 times, half an hour after meal, 3 months is a course of treatment.

Among the raw materials of traditional Chinese medicine of the present invention, Rhizoma Chinensis: sweet and cold, returns to lung, stomach and bladder meridian, cools blood and stops bleeding, clears away heat and diuresis; Capillaris: bitter, pungent, slightly cold, returns to spleen, stomach, liver and gallbladder meridian, clears damp and heat , anti-jaundice, for jaundice oliguria, eczema pruritus, infectious jaundice hepatitis; : pungent, warm, poisonous, return spleen, stomach, lung meridian, reduce adverse flow rate and stop vomiting, be used for vomiting and regurgitation, chest cavity full of oppression, Meihe Qi; Bupleurum: bitter, slightly cold, return liver meridian, gallbladder meridian, evacuate Antipyretic, raising yang and soothing the liver, common cold and fever, alternating cold and heat, malaria, stagnation of liver and qi stagnation, distending pain in the chest and ribs, prolapse of the anus, prolapse of the uterus, irregular menstruation; Clearing heat and cooling blood, nourishing yin and promoting body fluid; Dilong: cold and salty, enters the Liver, Spleen, and Bladder meridians, clears heat and calms wind, unblocks collaterals, relieves asthma, diuretic: Notoginseng: sweet, slightly bitter, warm, returns to the heart, liver , spleen meridian, blood stasis and hemostasis, blood circulation and analgesic; Licorice: sweet, flat, heart-guiding, spleen, lung, stomach meridian, invigorating spleen and Qi, moistening lung and relieving cough, clearing heat and detoxification, relieving pain and relieving drug properties; all medicines play a role in soothing the liver With the functions of invigorating the gallbladder and reducing jaundice, promoting blood circulation and removing stasis, dredging collaterals and nourishing the liver, the traditional Chinese medicine preparation of the present invention eliminates stagnation of liver and gallbladder qi, relieves liver damage, restores normal bile secretion and excretion functions, and plays a role in strengthening the body without stagnation of evils and eliminating evils. The effect of injury is positive, the cost is low, and it is worthy of clinical promotion and application.

Detailed ways

Example 1:

Chinese medicine raw materials: 180 parts of Chinensis, 180 parts of Yinchen, 90 parts of Atractylodes macrocephala, 90 parts of Jiang Pinellia, 90 parts of Bupleurum, 180 parts of Dihuang, 90 parts of Panax notoginseng, 90 parts of Dilong, 60 parts of licorice.

Preparation method: Take 180 parts of Chinensis, 180 parts of Yinchen, 90 parts of Atractylodes macrocephala, 90 parts of Jiang Pinellia, 90 parts of Bupleurum, 180 parts of Dihuang, 90 parts of Sanqi, 90 parts of Dilong, and 60 parts of Licorice, and decoct them twice with water. Each time the water consumption is 8-10 times the weight of the medicinal material, decoct twice, each time for 1-2 hours, filter, the filtrate is concentrated into a clear paste with a relative density of 1.10-1.25 measured at 60-65°C , add ethanol until the ethanol content is 60%, stir well, let it stand for 24 hours, filter, take the filtrate to recover ethanol, concentrate it into an extract containing 65-67% solid weight, add 20% sucrose, 12% refined honey , 1-3% of preservatives, potting the stock solution, sterilizing by irradiation, packaging the finished product, and making it into an oral liquid, to get final product.

Example 2:

Chinese medicine raw materials: 135 parts of Chinensis, 135 parts of Yin Chen, 60 parts of Atractylodes macrocephala, 60 parts of Jiang Pinellia, 60 parts of Bupleurum, 135 parts of Dihuang, 60 parts of Panax notoginseng, 60 parts of Dilong, 40 parts of licorice.

Preparation method: Take 135 parts of Chinensis, 135 parts of capillary, 60 parts of Atractylodes macrocephala, 60 parts of ginger pinellia, 60 parts of Bupleurum, 135 parts of rehmannia glutinosa, 60 parts of Sanqi, 60 parts of earthworm, and 40 parts of licorice, and decoct them twice with water. Each time the water consumption is 8-10 times the weight of the medicinal material, decoct twice, each time for 1-2 hours, filter, the filtrate is concentrated into a clear paste with a relative density of 1.10-1.25 measured at 60-65°C , add ethanol until the ethanol content is 60%, stir well, let it stand for 24 hours, filter, take the filtrate to recover ethanol, concentrate it into an extract containing 65-67% solid weight, add 20% sucrose, 12% refined honey , 1-3% of preservatives, potting the stock solution, sterilizing by irradiation, packaging the finished product, and making it into an oral liquid, to get final product.

Example 3:

Chinese medicine raw materials: 90 parts of Chinensis, 90 parts of Yin Chen, 30 parts of Atractylodes macrocephala, 30 parts of Jiang Pinellia, 30 parts of Bupleurum, 90 parts of Dihuang, 30 parts of Panax notoginseng, 30 parts of Dilong, 30 parts of licorice.

Preparation method: Take 90 parts of Chinensis, 90 parts of Yinchen, 30 parts of Atractylodes macrocephala, 30 parts of Jiang Pinellia, 30 parts of Bupleurum, 90 parts of Dihuang, 30 parts of Sanqi, 30 parts of Dilong, and 30 parts of Licorice, and decoct them twice with water. Each time the water consumption is 8-10 times the weight of the medicinal material, decoct twice, each time for 1-2 hours, filter, and the filtrate is concentrated into a clear paste with a relative density of 1.10-1.25 measured at 60-65°C , add ethanol until the ethanol content is 60%, stir well, let it stand for 24 hours, filter, take the filtrate to recover ethanol, concentrate it into an extract containing 65-67% solid weight, add 20% sucrose, 12% refined honey , 1-3% of preservatives, potting the stock solution, sterilizing by irradiation, packaging the finished product, and making it into an oral liquid, to get final product.

Example 4:

1) Clinical data: 25 cases of chronic hepatitis, 19 males and 6 females, aged 21-55 years.

The present invention takes chronic hepatitis of traditional Chinese medicine as an example, through clinical observation of 25 cases. Choose the standard of TCM diagnosis of chronic hepatitis: weak limbs, lack of energy, anorexia, abdominal distension, indigestion; dark complexion, liver face; dull pain in the liver area; severe liver fibrosis; abnormal liver function transaminases, other indicators such as plasma Albumin, total blood bilirubin, etc. were unqualified. The above symptoms can be diagnosed.

Among the confirmed observation objects, there were 19 males and 6 females, without other serious diseases, aged 21 to 55 years.

2) Judgment of curative effect:

Significantly effective: fatigue relieved, body energetic; anorexia, abdominal distension, dull pain in the liver area relieved, and the liver area comfortable; liver complexion improved, and the complexion became fair; liver fibrosis examination was significantly relieved.

Effective: Fatigue is resolved, the body is strong, abdominal distension, anorexia, and liver complexion are relieved.

Invalid: no change in symptoms.

3) Treatment method: take orally, 20 ml each time of Example 1 of the present invention, 3 times a day, half an hour after meals, 3 months as a course of treatment.

4) Treatment results: The patient took the traditional Chinese medicine oral liquid of Example 1 of the present invention, and the symptoms were relieved after 1 month, and the symptoms were obviously improved after 3 months of taking. Among the 25 people in the clinical trial, 15 people were markedly effective, 9 people were effective, and 1 person was ineffective, and the total effective rate was 96%.

Example 5:

Typical case: Deng Mou, female, 45 years old, was diagnosed as a patient with chronic hepatitis, with weakness in limbs, anorexia, dull pain in the right rib, dry mouth and bitter mouth for 1.5 years. Hepatitis B surface antigen was positive in laboratory tests for 2 years. Invention Example 1 Chinese medicine oral liquid, the symptoms were relieved after 1 month, and the symptoms were obviously improved after 3 months of taking. After three courses of treatment, the liver function was normal, and the subjective symptoms disappeared.

Embodiment 6:

Typical case: Wang Mou, male, 57 years old, was diagnosed as a patient with chronic hepatitis. He did not receive any treatment, and later he paid attention to his condition due to poor diet, nausea and vomiting, yellow skin, and yellow sclera. He took the embodiment of the invention 1 Traditional Chinese medicine oral liquid, the symptoms were relieved after 1 month, and the symptoms were obviously improved after 3 months of taking. After three courses of treatment, the liver function was normal, and the subjective symptoms disappeared.

Claims (1)

1. treat the preparation method of chronic hepatitis Rhizoma Imperatae Chinese medicine oral liquid, it is characterized in that: concrete steps are as follows:

Raw material of Chinese medicine preparation by following weight portion, get 90 parts of Rhizoma Imperataes, 90 parts of Herba Artemisiae Scopariaes, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 30 parts of Radix Bupleuri, 90 parts of Radix Rehmanniae, 30 parts of Radix Notoginseng, 30 parts of Pheretimas, 30 parts, Radix Glycyrrhizae, water decocts secondary, 8 times of amounts that each water consumption is medical material weight, decoct secondary, each 2 hours, filter, filtrate is condensed into the clear paste of surveying relative density 1.25 at 65 ℃, adding ethanol is 60% to making containing amount of alcohol, stir evenly, standing 24 hours, filter, get filtrate recycling ethanol, be condensed into the extractum containing solid weight 67%, add sucrose 20%, refined honey 12%, antiseptic 1-3%, the stock solution embedding, irradiation sterilization, packed products, make oral liquid, obtain.