CN102641353A - Hair growth conditioner rich in plant flavonoids - Google Patents
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Abstract
The invention discloses a hair growth conditioner rich in plant flavonoids, which is prepared by the following raw materials in ratio by weight: 30 to 90 of plant extract and 0.3 to 0.9 of synergist, wherein the plant extract is calculated on the basis of total flavonoids, the weight content of the total flavones is 10 to 50%, and the synergist is obtained by mixing niacinamide, vitamin B6, and zinc sulfate according to the weight ratio of 1 to 3:1 to 3:1 to 3. Compared with the prior art, the product provided by the invention utilizes a flavonoid compound in the plant extract to inhibit the generation of reductase leading to hair loss, and the synergist and the plant extract according to a special ratio have a synergistic effect, so that the active ingredient in the plant extract can better penetrate in stratum corneum and sebum of the hair skin and plays stronger hair growth, strengthening and blackening effects so as to further enhance the efficacies of loss prevention and hair growth promotion, and thus the hair loss can be prevented from the root.
Description
Technical Field
The invention relates to a composition for promoting hair regeneration, in particular to a hair restorer rich in plant flavonoids.
Background
Alopecia is a dermatological disease with a certain incidence among people, and the etiology and pathogenesis of alopecia are not completely clear. Alopecia has certain inheritance, and can be related to endocrine, autoimmunity, spirit, infection, poisoning and other factors in the later days.
At present, the treatment mode of alopecia comprises western medicines, traditional Chinese medicines and Chinese and western medicines. The western medicines mainly adopt finasteride, minoxidil, anthralin and other medicines for treatment, but the western medicines have the defect of large side effect.
The invention discloses a Chinese and western medicine combined treatment patent with publication number CN1745813, which discloses an activin for preventing alopecia and growing hair, which is composed of finasteride, fleece-flower root, cacumen biotae, vitamin B6 and garlic, and the preparation method comprises decocting fleece-flower root and cacumen biotae in 300ml of water, cooling and pouring into 450ml of plastic bottle; squeezing Bulbus Allii, and placing into another small bottle; then grinding finasteride and vitamin B6 into powder, pouring into a bottle, and fully stirring with the garlic juice; pouring the materials in the bottle into a plastic bottle, adding water, and stirring. Also disclosed is an external preparation for treating alopecia, as disclosed in patent CN1244129C, wherein the dosage ratio of each component in each 1000ml of the preparation is: 20-50 ml of lipid-soluble penetrant, 50-100 g of hydration penetrant, 0.05-0.2 g of enzyme preparation, 20ml of antiandrogen, 100-200 ml of Chinese medicinal tincture, 100-300 ml of capsicum tincture, 20ml of vitamin B complex liquid, 20-100 ml of scalp moisturizer and 10-100 ml of transdermal absorption enhancer, and finally adding a proper amount of absolute ethyl alcohol until the volume of liquid medicine is 1000 ml; the preparation method comprises the following steps:
lipid-soluble penetrant: dissolving nicotinamide or nicotinic acid in distilled water according to the proportion of 1: adding ethyl acetate at a ratio of 50, and stirring;
hydration agent: taking 50-100 parts of allantoin or urea for later use;
enzyme preparation: taking 0.15 part of cytochrome C or 0.05-0.2 part of adenosine triphosphate for later use;
anti-androgens: taking 0.05-0.2 g of dexamethasone and 0.05-0.1 g of estradiol benzoate or megestrol as 1 unit, and mixing the components in a ratio of 1: dissolving in 95% ethanol at a ratio of 20;
chinese medicinal tincture: weighing 10g of each of ginseng and cinnamon, 15g of each of safflower, glossy privet fruit and mulberry fruit, 20g of each of fleece-flower root, Chinese angelica, pseudo-ginseng, szechuan lovage rhizome, cacumen biotae, rhizoma atractylodis, parasitic loranthus, mulberry leaf, drynaria rhizome and Chinese honeylocust fruit, 30g of each of salvia miltiorrhiza, eclipta alba and garden balsam stem, crushing the medicinal materials, and soaking and extracting 800-1200 ml of 70% and 95% ethanol to obtain filtrate for later use;
a capsicum tincture: taking fresh chilli powder, and mixing the fresh chilli powder according to the proportion of 1: 3, soaking in 70% ethanol, and filtering to obtain filtrate;
vitamin B complex solution: collecting vitamin B11g、B20.05g、B61g is 1 unit, and the ratio of 1: dissolving in distilled water at a ratio of 20;
scalp moisturizer: taking 20-100 parts of propylene glycol or 20-50 parts of glycerol for later use;
transdermal absorption enhancer: taking 10-20 parts of azone or 50-100 parts of dimethyl sulfoxide for later use. The treatment effect of the treatment mode of the Chinese and western medicines is better, the dosage of the western medicine is reduced, the side effect of the medicine is reduced compared with the treatment of the pure western medicine, but the western medicine and the western medicine still have certain side effect and influence the human health after long-term use; in addition, the latter formulation is complex.
The invention discloses a pure traditional Chinese medicine for treating alopecia and leukotrichia as disclosed in the patent publication No. CN101284121, which is prepared from more than 30 traditional Chinese medicines of schizonepeta, divaricate saposhnikovia root, ginger, dried rehmannia root, tree peony bark, red paeony root, lightyellow sophora root, densefruit pittany root-bark, Indian buead, oriental waterplantain rhizome, broom cypress fruit, red-rooted salvia root, ginseng, safflower, Chinese date, tuber fleeceflower root, mulberry kanzi, Chinese angelica, fortune's drynaria rhizome, desertliving cistanche, prepared rhizome of rehmannia, sealwort, eucommia bark, black sesame, black bean, cordyceps sinensis, pheasant oil and the like. Also, for example, the invention patent with publication number CN101244021 discloses a growth liquid for regenerating human hair and eyebrows, which is prepared by soaking the following raw materials in 450-550 parts by weight of 65 ° sorghum liquor for 20-30 days, and filtering; the raw materials comprise 6-8 parts of eclipta, 4-6 parts of willow leaf, 4-6 parts of black sesame, 6-8 parts of cacumen biotae, 3-5 parts of mulberry leaf, 4-6 parts of chamomile and 1-2 parts of borneol. The growth liquid has simple formula and simplified process, but the anti-sloughing effect of the product is not specifically described. Further in accordance with the invention of publication No. CN101969921A, a hair growth promoting composition is disclosed comprising at least one aromatase inhibitor, which can be an extract of soybean and/or rapeseed, and at least one plant extract, preferably an extract rich in phytosterols and/or flavonoids, wherein the phytosterols and/or flavonoids are present in an amount of at least 50%, preferably 75%, and most preferably 90% by weight of the total plant extract.
Disclosure of Invention
The invention aims to solve the technical problem of providing the hair growth promoter which is rich in plant flavonoid substances, has good hair growth and hair-fixing effects, simple formula and small side effect.
In order to solve the technical problems, the hair restorer rich in plant flavonoids is prepared from the following raw materials in parts by weight:
30-90 parts of plant extract and 0.3-0.9 part of synergist; wherein,
the plant extract comprises, by weight, 10-50% of total flavonoids;
the synergist is composed of nicotinamide and vitamin B6And zinc sulfate according to the proportion of 1-3: 1-3: 1-3 by weight.
In the technical scheme, the plant extract with the total flavone content of 25-35% by weight is preferably selected.
In the above technical solution, it is more preferable to select a plant extract with a total flavone content of 30% by weight; is selected from nicotinamide and vitamin B6And zinc sulfate according to the proportion of 1: 1: 1, 1 weight ratio of the synergist.
In the above technical scheme, the plant extract is an extract obtained by extracting medicinal materials including ginkgo leaves and/or cacumen biotae and/or raspberry. The preparation method of the extract can be the conventional method comprising the steps of water extraction, separation and purification, and specifically can be the following steps: decocting the medicinal materials in water for extraction, passing an extracting solution through a macroporous resin column, performing gradient elution by using ethanol with the volume concentration of 45-75%, concentrating an eluent, extracting by using ethanol with the volume concentration of 90-100%, standing, filtering, recovering ethanol from a filtrate, and drying to obtain the traditional Chinese medicine composition. In the method, the extraction times are 1-3, the adding amount of water in each extraction can be 6-12 times of the weight of the medicinal materials, and the extraction time is 0.5-2 h; the macroporous resin is nonpolar styrene type macroporous resin, and the specific model can be D101, D101 or HP-20; the dosage of the ethanol used for elution is usually 1-2 times of the volume of the resin column bed; concentrating the eluent until the solid content is 40-50 percent, and stopping concentrating; the using amount of the ethanol for extraction is 3-5 times of the volume of the concentrated solution, and the standing time is usually 30-60 min.
In order to further enhance the hair blackening effect of the product, the medicinal materials in the plant extract preferably further comprise eclipta.
In order to further enhance the bactericidal effect of the product of the invention, the medicinal materials in the plant extract preferably further comprise mulberry leaves.
In the plant extract, the ratio of the medicinal materials can be any ratio, and the following ratio is preferably adopted:
when the medicinal materials are selected from ginkgo leaves, Chinese arborvitae twig and raspberry, the weight ratio of the ginkgo leaves, the Chinese arborvitae twig and the raspberry is preferably 30-90: 25-75: 20 to 60.
When the medicinal materials are selected from ginkgo leaves, cacumen biotae, raspberry and yerbadetajo herb, the weight ratio of the ginkgo leaves, the cacumen biotae, the raspberry and the yerbadetajo herb is preferably 30-90: 25-75: 20-60: 15-45.
When the medicinal materials are selected from ginkgo leaves, Chinese arborvitae twig, raspberry, yerbadetajo herb and mulberry leaves, the weight ratio of the ginkgo leaves, the Chinese arborvitae twig, the raspberry, the yerbadetajo herb and the mulberry leaves is preferably 30-90: 25-75: 20-60: 15-45: 10 to 30.
The product of the invention is mainly applied to androgenetic alopecia and stationary phase alopecia. The use mode of the product of the invention is as follows: the solution with the concentration of 30-100 mg/ml is prepared by using 20-50% (v/v) ethanol or water and is directly applied to the affected part for 1-3 times every day, the dosage of 1-3 ml each time is used, 24-48 days are taken as a treatment course, dandruff and pruritus are reduced after 3-6 treatment courses are generally used, and the hair growth is obviously increased. The product can also be added into shampoo for use, and the specific mixture ratio is that the product of the invention: shampoo = 0.03-0.06: 1, the shampoo is used once every 3 to 5 days, and the dosage is the dosage in the conventional shampoo.
Compared with the prior art, the product utilizes the flavone compounds in the plant extract to inhibit the generation of reductase causing alopecia, and the synergist and the plant extract in a special proportion have a synergistic effect, so that active ingredients in the plant extract can better permeate into the cuticle and sebum of scalp, and stronger hair growing and fixing effects are exerted, the effects of further enhancing alopecia prevention and promoting hair growing are achieved, and the alopecia is prevented fundamentally; in addition, the product of the invention also has good anti-inflammatory and antipruritic effects.
Detailed Description
The present invention is further illustrated by the following examples, but the present invention is not limited to these examples.
Example 1
1) Preparing a plant extract: taking 1500kg of medicinal materials (ginkgo leaves: cacumen biotae: raspberry: eclipta: mulberry leaves: 30: 25: 20: 15: 10), cleaning, crushing, placing in an extraction tank, adding water for extraction for 2 times (adding water with the weight 10 times of the medicinal materials for boiling extraction for 2h in the 1 st time, filtering, adding water with the weight 10 times of the medicinal materials for boiling extraction for 1.5h in filter residues), passing the obtained extract through a D101 macroporous resin column, eluting with ethanol with the volume 1 time of the column bed volume and 50% (v/v), collecting the eluent, eluting with ethanol with the volume 1 time of the column bed volume and 70% (v/v), collecting the eluent, combining the ethanol eluates, and carrying out vacuum concentration under the conditions of 60 ℃ and 0.05-0.08 MPa to obtain a concentrated solution with the solid content of 50%; adding 95% ethanol 4 times the volume of the concentrated solution into the concentrated solution, stirring, standing for 50min, filtering, recovering ethanol from the filtrate, and spray drying to obtain plant extract 45kg with total flavone content of 31.6%;
2) taking 45Kg of the plant extract obtained in step 1) and 0.45Kg of a synergist (nicotinamide: vitamin B6: zinc sulfate1: 1: 1) and fully and uniformly mixing to obtain the hair restorer rich in plant flavonoids.
Example 2
1) Preparing a plant extract: taking 2000kg of medicinal materials (ginkgo leaves: cacumen biotae: raspberry: eclipta: mulberry leaves: 50: 30: 40: 30), cleaning, crushing, placing in an extraction tank, adding water with the weight 12 times of the weight of the medicinal materials, boiling and extracting for 2h, filtering, passing the obtained extract through a D102 macroporous resin column, eluting by using ethanol with the volume 1 time of the column bed and 45% (v/v), collecting eluent, eluting by using ethanol with the volume 0.5 time of the column bed and 70% (v/v), collecting the eluent, combining the ethanol eluents, and carrying out vacuum concentration to obtain a concentrated solution with the solid content of 40%; adding 100% ethanol 5 times the volume of the concentrated solution into the concentrated solution, stirring, standing for 30min, filtering, recovering ethanol from the filtrate, and spray drying to obtain plant extract 60kg with total flavone content of 28.6%;
2) taking 30Kg of the plant extract obtained in step 1) and 0.6Kg of a synergist (nicotinamide: vitamin B6: zinc sulfate 1: 1.5: 1) and fully and uniformly mixing to obtain the hair restorer rich in plant flavonoids.
Example 3
1) Preparing a plant extract: cleaning 2000kg of ginkgo leaves, crushing, placing in an extraction tank, adding water for extraction for 3 times (adding water with the weight 10 times of the weight of medicinal materials for boiling extraction for 2 hours at the 1 st time, filtering, adding water with the weight 8 times of the weight of the medicinal materials for boiling extraction for 1 hour at the filter residue, filtering, adding water with the weight 6 times of the weight of the medicinal materials for boiling extraction for 0.5 hour at the filter residue), enabling the obtained extract to pass through a D103 macroporous resin column, eluting with 55% (v/v) ethanol with the volume 0.5 times of the volume of a column bed, collecting eluent, eluting with 65% (v/v) ethanol with the volume 0.5 times of the volume of the column bed, collecting the eluent, combining the ethanol eluent, and carrying out vacuum concentration to obtain a concentrated; adding 90% ethanol 3 times the volume of the concentrated solution into the concentrated solution, stirring, standing for 40min, filtering, recovering ethanol from the filtrate, and spray drying to obtain plant extract 50kg with total flavone content of 24.6%;
2) taking 90Kg of the plant extract obtained in step 1) and 0.3Kg of a synergist (nicotinamide: vitamin B6: zinc sulfate 2: 2: 1) and fully and uniformly mixing to obtain the hair restorer rich in plant flavonoids.
Example 4
1) Preparing a plant extract: taking 2000kg of medicinal materials (folium ginkgo: cacumen biotae is 1: 1), cleaning, crushing, placing in an extraction tank, adding water for extraction for 2 times (adding water with the weight 12 times of the medicinal materials for boiling extraction for 2 hours in the 1 st time, filtering, adding water with the weight 8 times of the medicinal materials for boiling extraction for 1 hour in filter residues), passing the obtained extract through an HP-20 macroporous resin column, eluting by using ethanol with the volume 1.5 times of the volume of a column bed and 50% (v/v), collecting eluent, eluting by using ethanol with the volume 0.5 times of the volume of the column bed and 70% (v/v), collecting eluent, combining ethanol eluent, and carrying out vacuum concentration to obtain concentrated solution with the solid content of 50%; adding 90% ethanol 4 times the volume of the concentrated solution into the concentrated solution, stirring, standing for 60min, filtering, recovering ethanol from the filtrate, and spray drying to obtain 66kg of plant extract with total flavone content of 27.5%;
2) 60Kg of the plant extract obtained in step 1) and 0.9Kg of a synergist (nicotinamide: vitamin B6: zinc sulfate 1: 3: 1) and fully and uniformly mixing to obtain the hair restorer rich in plant flavonoids.
Example 5
1) Preparing a plant extract: taking 2000kg of medicinal materials (folium ginkgo: cacumen biotae: folium mori: 20: 40: 30), cleaning, crushing, placing in an extraction tank, adding water with the weight 12 times of the medicinal materials, boiling and extracting for 2h, filtering, enabling the obtained extract to pass through a D101 macroporous resin column, eluting with 60% (v/v) ethanol with the volume 1 time of the volume of a column bed, collecting eluent, eluting with 75% (v/v) ethanol with the volume 0.3 time of the volume of the column bed, collecting the eluent, combining the ethanol eluents, and carrying out vacuum concentration to obtain a concentrated solution with the solid content of 50%; adding 100% ethanol 4 times the volume of the concentrated solution into the concentrated solution, stirring, standing for 50min, filtering, recovering ethanol from the filtrate, and spray drying to obtain plant extract 62kg with total flavone content of 26.3%;
2) taking 50Kg of the plant extract obtained in step 1) and 0.3Kg of a synergist (nicotinamide: vitamin B6: zinc sulfate 3: 2: 1) and fully and uniformly mixing to obtain the hair restorer rich in plant flavonoids.
In order to illustrate the effect of the hair restorer rich in plant flavonoids, the applicant respectively carried out a hair growth promotion experiment, an anti-inflammatory experiment and an itching relieving experiment by using the product of the invention.
1. Hair growth promotion experiment
1.1 test agent:
the experimental group was given as formulation 1: the germinant rich in plant flavonoids prepared in the embodiment 1 of the invention is prepared into liquid medicine with the concentration of 50mg/ml by using 30% (v/v) ethanol.
The control group was dosed as dose 2: the plant extract prepared in the step 1) of the embodiment 1 of the invention is prepared into liquid medicine with the concentration of 50mg/ml by using 30% (v/v) ethanol.
1.2 Experimental methods and results
Selecting a C57BL/6 mouse with the weight of 18-22 g (female parent)
For both purposes, 22 mice were bred for one week, acclimatized, and randomly divided into control group and experimental group, and depilatory (Na) was added2S) symmetrically coating the depilatory paste on two sides (one side is a medicament side and the other side is a blank side) of the back of a mouse, depilating after about 2-3 minutes, cleaning with warm water, and taking care that the depilatory paste does not damage the skin, wherein the area of one side is 2cm multiplied by 2cm, and the back of the mouse is smooth and has no injury or residual hair. The drug side of the experimental group was coated with drug 1 (0.1 ml/time), the blank side was coated with 30% ethanol solution (0.1 ml/time), the drug side of the control group was coated with drug 2 (0.1 ml/time), the blank side was coated with 30% ethanol solution (0.1 ml/time), and the two groups were coated with drug every dayIt is administered for 24 days at 2 times. Taking 10 longest hairs in the hair removal treatment area (medicament side and blank side) in the last day of the experiment, measuring the length by using a vernier caliper under a magnifying glass, calculating an average value as the length of the newly grown hairs in the hair removal area of each mouse, and calculating the average value of the hair length of each group of mice; a round skin piece with the diameter of 1cm is taken at the same position of the back of each mouse, all body hair on the skin piece is scraped by a blade, and the weight average value of the hair of each group of mice is obtained by weighing. The results are shown in tables 1 and 2 below.
Table 1: effect of Germin rich in phytoflavonoids on the Length of Hair regrowth in mice (n = 10)
Note:*P＜0.05，**p is less than 0.01, compared with the same dosage control group.
Table 2: effect of Hair restorer rich in plant Flavonoids on weight of newborn hair of mice (n = 10)
Note:*p is less than 0.05, compared with the same dose control group.
As can be seen from the data in tables 1 and 2, the experimental group of the hair restorer rich in plant flavonoids prepared by the invention is externally applied for 24 days continuously, the length of the new hair on the medicament side of the animal mouse is increased by 104.54mm compared with the blank side, and the weight of the new hair on the medicament side is increased by 49.30mg compared with the blank side; the control group directly using the plant extract prepared in step 1) of example 1 showed no significant difference in the length and weight of the new hair between the drug side and the blank side coated with the same dose. The hair growth promoter which is externally coated with the substance rich in the plant flavonoid has obvious effect of promoting hair growth, and can obviously increase, thicken and thicken the hair of mice.
2. Experiment of anti-inflammatory Effect
2.1 test agent:
the experimental group was administered as agent 3: the germinant rich in plant flavonoids prepared in the embodiment 1 of the invention is prepared into liquid medicine with the concentration of 30mg/ml by using 30% (v/v) ethanol.
The control group was dosed with formulation 4: the plant extract prepared in the step 1) of the embodiment 1 of the invention is prepared into liquid medicine with the concentration of 30mg/ml by using 30% (v/v) ethanol.
The model group drugs were drug 5: 30% ethanol solution.
2.2 Experimental methods and results
Selecting male KM mice with SPF (specific pathogen free) grade and body weight of 18-22 g
The combination is that 10% Na is adopted by all groups of animals from the first day of experiment2The S solution is unhaired in the back, and then the animals are randomly divided into a model group, a control group and an experimental group according to the weight; the experimental group was coated with 3 doses (1 ml/time), the control group with 4 doses (1 ml/time), and the model group with 5 doses (1 ml/time). The three groups are applied externally 2 times per day for 14 days. Uniformly coating 0.02mL of dimethylbenzene on the right ear after 60min of the last administration, taking off the cervical vertebra after 15min, killing the cervical vertebra, punching a round ear piece on the same part of the two ears by using a puncher respectively, and weighing. The swelling degree (swelling degree = right ear weight — left ear weight) was calculated, and the results are shown in table 3.
TABLE 3 Effect of germinants rich in phytoflavonoids on xylene-induced ear swelling in mice
Comparing with model group and control group*P<0.05，**P<0.01。
As shown in Table 3, compared with a model group, after the hair growth hormone rich in the plant flavonoid substances is externally applied for 14 days continuously, the inhibition rate of inflammation-induced swelling of an experimental group reaches 75.88%, the inflammation-induced swelling of mouse auricles (P is less than 0.01) caused by xylene can be remarkably reduced, the swelling degree of a control group has no obvious influence, and the result shows that the hair growth hormone rich in the plant flavonoid substances has a good anti-inflammatory effect.
3. Test for antipruritic Effect
3.1 test agent:
the experimental group was dosed as dose 6: the germinant rich in plant flavonoids prepared in the embodiment 1 of the invention is prepared into liquid medicine with the concentration of 30mg/ml by using 30% (v/v) ethanol.
The control group was dosed as dose 7: the plant extract prepared in the step 1) of the embodiment 1 of the invention is prepared into liquid medicine with the concentration of 30mg/ml by using 30% (v/v) ethanol.
The model group is used as a medicament 8: 30% ethanol solution.
3.2 Experimental methods and results
Selecting male KM mice with SPF (specific pathogen free) grade and body weight of 18-22 g
The method is used simultaneously, wherein all groups of animals adopt 10% NaS solution to unhair in the back from the first day of the experiment, and then the animals are randomly divided into a control group, an experimental group and a model group according to the weight; the experimental group was coated with 6 doses (1 ml/time), the control group with 7 doses (1 ml/time), and the model group with 8 doses (1 ml/time). The three groups are applied externally 2 times per day for 10 consecutive days. After 30min of the last application, 0.025% dextran was injected into the tail vein of the mouse, the head of the mouse was scratched by the front paw, the trunk of the mouse was scratched by the rear paw, and the parts of the whole body were gnawed to be used as the indication of itching, and the onset of itching in the mouse was recorded within 30minFrequency and latency to onset of pruritus. The results are shown in Table 4.
TABLE 4 Effect of germinants rich in plant flavonoids on dextran induced pruritus in mice ((
n=10）
Comparison with model control group*P<0.05
As can be seen from Table 4, after the medicine is externally applied for 10 consecutive days, compared with the model group, the scratching times caused by the intravenous injection of dextran of the experimental group are reduced by 30 percent (P is less than 0.05), and the scratching latency is prolonged by 96 percent (P is less than 0.05); while the reduction in the number of scratches was reduced but not significant in the control group. The result shows that the plant flavonoid-rich hair restorer of the invention has stronger antipruritic effect on the pruritus reaction caused by dextran.
In order to illustrate the effect of the product of the invention in treating alopecia, the applicant carries out clinical observation and treatment on 100 alopecia patients, specifically as follows:
1. clinical data:
among 100 patients, male accounts for 80%, female accounts for 20%, the longest course of disease lasts for 8 years, and the shortest course of disease lasts for 1 year. Among 100 patients, there were 48 alopecia areata and 52 alopecia areata, 65 years old and 30 years old.
2. Method of treatment
The test drugs are: the hair restorer rich in plant flavonoids prepared in the embodiment 1 of the invention is prepared into liquid medicine with the concentration of 50mg/ml by using 30% (v/v) ethanol.
The test medicine is externally applied to the affected part of 100 patients, the dosage is 2ml each time, 2 times each day, 30 days as a treatment course, and 3 treatment courses are continuously used.
3. Evaluation criteria
The effect is shown: the bald part of the scalp grows exuberant hair and becomes thicker gradually.
The method has the following advantages: the scalp with baldness has thin hair.
And (4) invalidation: no hair grows from bald areas.
4. Clinical treatment results
The results of clinical treatment of 100 patients are shown in table 4 below:
| therapeutic effects | Show effect | Is effective | Invalidation | High efficiency |
| Number of people | 70 | 13 | 17 | |
| Percentage of | 70% | 13% | 17% | 83% |
Claims (10)
1. A hair growth promoter rich in plant flavonoids is characterized by being prepared from the following raw materials in parts by weight:
30-90 parts of plant extract and 0.3-0.9 part of synergist; wherein,
the plant extract comprises, by weight, 10-50% of total flavonoids;
the synergist is composed of nicotinamide and vitamin B6And zinc sulfate according to the proportion of 1-3: 1-3: 1-3 by weight.
2. The hair tonic rich in plant flavonoids according to claim 1, characterized in that: the plant extract contains 25-35 wt% of total flavonoids.
3. The hair tonic rich in plant flavonoids according to claim 1, characterized in that: the plant extract is calculated by total flavonoids, and the weight content of the total flavonoids is 30 percent; the synergist is composed of nicotinamide and vitamin B6And zinc sulfate according to the proportion of 1: 1: 1 by weight ratio.
4. The plant flavonoid-rich hair growth promoter according to any one of claims 1 to 3, wherein: the plant extract is obtained by extracting medicinal materials including ginkgo leaves and/or cacumen biotae and/or raspberry.
5. The hair tonic rich in plant flavonoids according to claim 4, characterized in that: the preparation method of the plant extract comprises the following steps: decocting the medicinal materials in water for extraction, passing an extracting solution through a macroporous resin column, performing gradient elution by using ethanol with the volume concentration of 40-80%, concentrating an eluent, extracting by using ethanol with the volume concentration of 90-100%, standing, filtering, recovering ethanol from a filtrate, and drying to obtain the traditional Chinese medicine composition.
6. The hair tonic rich in plant flavonoids according to claim 4, characterized in that: the medicinal materials also comprise yerbadetajo herb.
7. The hair tonic rich in plant flavonoids according to claim 6, characterized in that: the medicinal materials also comprise mulberry leaves.
8. The hair tonic rich in plant flavonoids according to claim 4, characterized in that: when the medicinal materials are selected from ginkgo leaves, Chinese arborvitae twig and raspberry, the weight ratio of the ginkgo leaves, the Chinese arborvitae twig and the raspberry is 30-90: 25-75: 20 to 60.
9. The hair tonic rich in plant flavonoids according to claim 6, characterized in that: when the medicinal materials are selected from ginkgo leaves, cacumen biotae, raspberry and yerbadetajo herb, the weight ratio of the ginkgo leaves, the cacumen biotae, the raspberry and the yerbadetajo herb is 30-90: 25-75: 20-60: 15-45.
10. The hair tonic rich in plant flavonoids according to claim 7, characterized in that: when the medicinal materials are selected from ginkgo leaves, Chinese arborvitae twig, raspberry, yerbadetajo herb and mulberry leaves, the weight ratio of the ginkgo leaves, the Chinese arborvitae twig, the raspberry, the yerbadetajo herb and the mulberry leaves is 30-90: 25-75: 20-60: 15-45: 10 to 30.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN107184629A (en) * | 2017-06-23 | 2017-09-22 | 高楠 | The preparation method and application of eclipta grass active ingredient |
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| EP2247276B1 (en) * | 2008-01-24 | 2019-12-25 | Irmgard Mathieu | Hair growth agent |
| CN113288853A (en) * | 2021-03-02 | 2021-08-24 | 本草生活(北京)医学研究有限公司 | Natural composition tincture for nourishing hair follicles, preventing alopecia, promoting hair growth, resisting inflammation and resisting bacteria and preparation method thereof |
| CN116803404A (en) * | 2023-08-24 | 2023-09-26 | 汤臣倍健股份有限公司 | Application of water-soluble tomato concentrate in preparation of hair loss reducing and hair growing products |
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| CN116803404A (en) * | 2023-08-24 | 2023-09-26 | 汤臣倍健股份有限公司 | Application of water-soluble tomato concentrate in preparation of hair loss reducing and hair growing products |
| CN116803404B (en) * | 2023-08-24 | 2023-12-15 | 汤臣倍健股份有限公司 | Application of water-soluble tomato concentrate in preparation of hair loss reducing and hair growing products |
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