CN102600422B

CN102600422B - Traditional Chinese medicine mixture for treating angina pectoris at catabatic period

Info

Publication number: CN102600422B
Application number: CN 201110404813
Authority: CN
Inventors: 王国荣; 王云杰; 于长虹
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-11-28
Filing date: 2011-11-28
Publication date: 2013-12-18
Anticipated expiration: 2031-11-28
Also published as: CN102600422A

Abstract

The invention discloses a traditional Chinese mixture for treating angina pectoris at the catabatic period. Traditional Chinese medicine holds that the angina pectoris belongs the field of traditional Chinese medical science 'chest apoplexy' and 'cardiodynia', is slow in hematogenous aspect and stagnates dampness for sputum crudum; and the obstruction caused by stagnation is premise and base for causing the angina pectoris. The treatment for relieving the angina pectoris at the catabatic period in clinical application aims at invigorating spleen to remove phlegm, promoting circulation and removing stasis and smoothing liver and regulating vital energy. Therefore, the mixture is prepared from ginseng, ligusticum wallichii, grassleaf sweelflag rhizome, astragalus root, pueraria root, cynanchum paniculatum, salviae miltiorrhizae, radix bupleuri, turmeric and radix sophorae flavescentis and is taken by patients; and through clinical trials conducted by plastic surgery hospital, the total effective rate for improving the angina pectoris symptoms reaches 96.0 percent; the paroxysm frequencies of the angina pectoris are reduced; and the traditional Chinese mixture can be better used for electrocardiogram while improving clinical symptoms and is worthy of being popularized and applied.

Description

A kind of anginal herb mixture of catabasis for the treatment of

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of anginal herb mixture for the treatment of.

Background technology

Angina pectoris is coronary insufficiency, cardiac muscle sharply, temporary transient ischemia and the caused clinical syndrome of anoxia.Its characteristics are paroxysmal shirtfront squeezing property pain perception, can be with other symptoms, and pain mainly is positioned at the breastbone rear portion, can be radiated to pareordia and left upper extremity, often betides work or when excited, continues several minutes, has a rest or with disappearing after nitrate preparations.Primary disease is more common in the male, and most patients are more than 40 years old, tired, excited, is satiated with food, catches cold, rainy weather, and acute circulatory failure etc. are common inducement.

Angina pectoris is mostly all because tired and cause, adds the emotion metropolis that rose and fell and causes this disease.This disease be not generally in the early stage so obviously, so people generally do not take much count of.

Anginal Therapeutic Method mainly contains Drug therapy and operative treatment, mainly takes nitroglycerin, isosorbide dinitrate, mitigate the disease at once during angina pectoris attacks; Anginal Therapeutic Method of catabasis, mainly take the lasting angina pectoris treatment medicine of effect in case angina pectoris attacks, and clinical practice proves, in the angina phase, adopts treatment by Chinese herbs, and effect is better.

Summary of the invention

The purpose of this invention is to provide a kind of anginal herb mixture of catabasis for the treatment of.The traditional Chinese medical science is thought: angina pectoris belongs to the traditional Chinese medical science " thoracic obstruction " and " pained " category, is more common in recent years clinically middle-aged and elderly people, and the disease being located in the heart is dirty relevant with spleen and Liver and kidney three.Blood is slow, accumulatively wet raise phlegm, the stasis of blood and obstructed be this pathogenetic prerequisite and basis.Should be from invigorating the spleen for dissipating phlegm in clinical anginal treatment of middle catabasis, blood circulation promoting and blood stasis dispelling, liver-smoothing, qi-regulating is started with.

The objective of the invention is to be achieved through the following technical solutions, this anginal herb mixture for the treatment of catabasis is made by the Chinese medicine of following weight portion: Radix Ginseng 8-12 part, Rhizoma Chuanxiong 10-15 part, Rhizoma Acori Graminei 8-12 part, Radix Astragali 15-25 part, Radix Puerariae 10-20 part, Radix Cynanchi Paniculati 10-20 part, Radix Salviae Miltiorrhizae 13-19 part, Radix Bupleuri 10-15 part, Rhizoma Curcumae Longae 8-12 part, Radix Sophorae Flavescentis 8-12 part.

Preferably, this anginal herb mixture for the treatment of catabasis is made by the Chinese medicine of following weight portion: 10 parts of Radix Ginsengs, 12 parts of Rhizoma Chuanxiongs, 10 parts of Rhizoma Acori Gramineis, 20 parts of the Radixs Astragali, 15 parts of Radix Puerariaes, 15 parts of Radix Cynanchi Paniculati, 16 parts of Radix Salviae Miltiorrhizaes, 12 parts of Radix Bupleuri, 10 parts, Rhizoma Curcumae Longae, 10 parts of Radix Sophorae Flavescentiss.

Above Chinese medicine is made to mixture by the Drug Manufacturing Room of the court by traditional method.

Radix Ginseng strongly invigorating primordial QI in side, multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid and inducing sedation of the mind; The Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping; Rhizoma Acori Graminei a surname gas is by expectorant, and parasite killing detoxifies; Radix Astragali benefiting QI for strengthening the superficies, arresting sweating take off, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema admittedly; Radix Puerariae induces sweat and brings down a fever, the rash of promoting the production of body fluid, yang invigorating antidiarrheal; The Radix Cynanchi Paniculati removing dampness of dispeling the wind, antalgesic-antipruritic; The Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind; Radix Bupleuri is evacuated and is brought down a fever, the yang invigorating soothing liver-QI; The circulation of qi promoting of Rhizoma Curcumae Longae removing blood stasis, inducing menstruation to relieve menalgia; The Radix Sophorae Flavescentis heat clearing and damp drying, wind dispelling insecticide.

Clinical data

1, physical data selected 200 routine patients all carry out self-gate exanthema example, are divided at random treatment group and matched group, every group of each 100 examples.In treatment group, male 56 examples, female's 44 examples, 58 years old mean age.The course of disease 1.5 months～24 years, average 6.5 years.34 examples that the state of an illness is slight, moderate 51 examples, than severe 15 examples.Average 8.20 ± 5.5 times/week of attack times of angina pectoris before treatment, tcm symptom average integral 18.50 ± 6.30 minutes; Matched group 100 examples, male 57 examples, female's 43 examples, 57 years old mean age.The course of disease 1 month～23 years, average 6.2 years.35 examples that the state of an illness is slight, moderate 49 examples, than severe 16 examples.Average 8.18 ± 6.10 times/week of attack times of angina pectoris before treatment.Tcm symptom average integral 17.95 ± 7.20 minutes.At aspects such as sex, age, the course of disease, the state of an illness, tcm symptom average integral and the average attack times variations of angina pectoris relatively, there was no significant difference (P>0.05), have comparability for treatment group and matched group.

2, include the case standard in and there is the obstruction of qi in the chest and cardialgia main symptom, tcm diagnosis is clear and definite, meet the turbid syndrome of blood stasis of Chinese medical discrimination expectorant, angina pectoris (stable type angina pectoris) patient who shows effect weekly more than 2 times, Electrocardioscopy has ischemic change or the exercise test positive, and the age was 18～65 years old person.

3, Therapeutic Method treatment group herb mixture of the present invention, each 100ml, every day is sooner or later respectively once; Matched group with comfortable peaceful (form: Fructus Trichosanthis skin, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami etc. (produced lot number by the changde, hunan pharmaceutical factory of traditional Chinese medicine: 970927), each 5, oral, every day 3 times.Be 4 weeks the course for the treatment of.

Treatment fore-and-aft observing patient clinical symptom, picture of the tongue, pulse condition, angina pectoris attacks situation, the variation of nitroglycerin consumption, electrocardiogram, blood, urine, just conventional, hepatic and renal function.

4, curative effect determinate standard is evaluated with reference to " the Angina evaluation criteria " of Chinese doctor trained in Western medicine combined treatment angina pectoris in 1979 and arrhythmia forum revision.

(1) angina pectoris symptom criterion of therapeutical effect produce effects: disappear or the angina pectoris symptom that substantially disappears.Improve: pain attack times, degree and persistent period obviously alleviate.Invalid: symptom is substantially with identical before treatment.

(2) ECG curative effect evaluation criteria produce effects: electrocardiogram returns to roughly normal, or reaches normal ECG.Improve: being reduced in after treatment more than rise 0.05mV of S-T section, but do not reach normal level, change shallow (reaching 25% above person) at the inverted T ripple of main connection, or the T ripple by smooth uprightly, room formula or intraventricular block improver.Invalid: electrocardiogram is basic with front identical.Increase the weight of: the S-T section is treated front reduction more than 0.05mV, at the inverted T ripple of mainly leading, deepens (reaching more than 25%), or upright T ripple flattens smoothly, and smooth T ripple becomes to be inverted, and ectopic cardiac rhythm, atrioventricular block or intraventricular block occur.

(3) myocardial ischemia-area curative effect produce effects: ischemic areas reduces more than 4/5.Take a turn for the better: ischemic areas reduces more than 1/2 but does not reach 4/5.Invalid: ischemic areas reduces obviously or increases.

5, produce effects 49 examples (49.0%) in therapeutic outcome (1) curative effect to treat angina pectoris treatment group 100 examples, improve 47 examples (47.0%), invalid 4 examples (4.0%), total effective rate 96.0%.Produce effects 21 examples (21.0%) in matched group 100 examples, improve 67 examples (67.0%), invalid 13 examples (13.0%), total effective rate 87.0%.Between learn processing by statistics two groups, obvious effective rate and total effective rate have significant difference (P<0.005).

(2) produce effects 45 examples (45.0%) in ECG curative effect treatment group 100 examples, improve 47 examples (47.0%), invalid 8 examples (8.0%), total effective rate 92.0%.Produce effects 35 examples (35.0%) in matched group 100 examples, improve 41 examples (41.0%), invalid 24 examples (24.0%), total effective rate 76.0%.Result shows, treatment group obvious effective rate and total effective rate, all higher than matched group, are learned and processed (P<0.05) by statistics, and significant difference is arranged.

(3) dwindle the myocardial ischemia-area curative effect, wherein treatment group 52 examples are done the color ultrasound examination ischemic areas, check after treatment: produce effects 31 examples as a result, and 21 examples that take a turn for the better, all effectively.Matched group 31 examples, effective 11 examples wherein, invalid 20.Its ischemic areas improves situation, and treatment group is by (210.80 ± 135.0) mm ²be reduced into (70.25 ± 81.40) mm ², matched group is by (190.50 ± 80.50) mm ²be reduced into (150.60 ± 82.20) mm ², to learn and process by statistics, two groups of curative effects have significant difference (P<0.05).

(4) untoward reaction is observed case before and after treatment, through having a blood test, urinate, just, hepatic and renal function, no abnormal change.

The specific embodiment

Embodiment mono-: take Radix Ginseng 100g, Rhizoma Chuanxiong 120g, Rhizoma Acori Graminei 100g, Radix Astragali 200g, Radix Puerariae 150g, Radix Cynanchi Paniculati 150g, Radix Salviae Miltiorrhizae 160g, Radix Bupleuri 120g, Rhizoma Curcumae Longae 100g, Radix Sophorae Flavescentis 100g.Make mixture by I Drug Manufacturing Room of institute by traditional method, take for the patient.

Embodiment bis-: take Radix Ginseng 80g, Rhizoma Chuanxiong 150g, Rhizoma Acori Graminei 80g, Radix Astragali 150g, Radix Puerariae 200g, Radix Cynanchi Paniculati 100g, Radix Salviae Miltiorrhizae 130g, Radix Bupleuri 150g, Rhizoma Curcumae Longae 120g, Radix Sophorae Flavescentis 80g.Make mixture by I Drug Manufacturing Room of institute by traditional method, take for the patient.

Embodiment tri-: take Radix Ginseng 120g, Rhizoma Chuanxiong 100g, Rhizoma Acori Graminei 120g, Radix Astragali 250g, Radix Puerariae 100g, Radix Cynanchi Paniculati 200g, Radix Salviae Miltiorrhizae 190g, Radix Bupleuri 100g, Rhizoma Curcumae Longae 80g, Radix Sophorae Flavescentis 120g.Make mixture by I Drug Manufacturing Room of institute by traditional method, take for the patient.

Claims

1. a treatment anginal herb mixture of catabasis, is characterized in that anginal herb mixture of this treatment catabasis made by the Chinese medicine of following weight: Radix Ginseng 100g, Rhizoma Chuanxiong 120g, Rhizoma Acori Graminei 100g, Radix Astragali 200g, Radix Puerariae 150g, Radix Cynanchi Paniculati 150g, Radix Salviae Miltiorrhizae 160g, Radix Bupleuri 120g, Rhizoma Curcumae Longae 100g, Radix Sophorae Flavescentis 100g.