CN102430094B - Traditional Chinese medicine decoction for treating angina pectoris - Google Patents
Traditional Chinese medicine decoction for treating angina pectoris Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine decoction for treating angina pectoris. According to traditional Chinese medicine, the causes of the angina pectorisare usually deficiency of vital energy and deficiency of yang, and the pathogenesis of the angina pectoris takes the yang deficiency of spleen and kidney as the base and the aeipathia deficiency of both YIN and YANG, blood stasis, phlegm, stagnation of Qi and cold sensation of the genitalia as symptoms. Therefore, in Chinese traditional treatment, promoting blood circulation and removing blood stasis and tonifying Qi and lifting yang are taken as the rules of treatment. Radix bupleuri, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae, monkshood, Codonopsis pilosula, prepared rehmannia root, liquorice, red flower, leonurus, radix achyranthis bidentatae and radix curcumae are scientifically blended and proportioned into the decoction. Through clinical tests of patients, the decoction prepared by the department of pharmaceutical preparation in our hospital reaches 93.5 percent in total effective rate, has no adverse reactions and low treatment cost and is worthy of being popularized and applied.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, have to relate to a kind of Chinese medicine decoction for the treatment of angina pectoris.
Background technology
Angina pectoris is coronary insufficiency, cardiac muscle sharply, temporary transient ischemia and the caused clinical syndrome of anoxia.Its characteristics are paroxysmal shirtfront squeezing property pain perception, can be with other symptoms, and pain mainly is positioned at the breastbone rear portion, can be radiated to pareordia and left upper extremity, often betides work or when excited, continues several minutes.Primary disease is more common in the male, and most patients are more than 40 years old, and are tired, excited, is satiated with food, catches cold, rainy weather, and acute circulatory failure etc. are common inducement.
Modern medicine shows, the basic pathological changes of coronary heart disease is the cirrhosis of coronary artery medicated porridge sample, and its morbidity is relevant with factors such as hyperlipidemia, diabetes, hypertension, obesities.Cause mainly due to the rising of the low density lipoprotein, LDL in blood (LDL) level and vascular endothelial injury.Treating clinically angina pectoris often selects nitrate esters to expand the blood vessel medicine.Sorbitrate is the antianginal drug of generally acknowledging both at home and abroad in nitrate esters, but its side effect such as headache feeling of fullness in the head that cause is fairly obvious, and drug resistance is arranged.In the last few years, use the auxiliary or alternative traditional mononitrate ester healer of Chinese medicine, became the focus of clinical research.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine decoction for the treatment of angina pectoris.The traditional Chinese medical science thinks that the primary disease cause of disease mostly is the deficiency of vital energy and yang deficiency, and its pathogenesis is take heart deficiency of spleen-YANG and kidneyYANG as this, the prolonged illness deficiency in both YIN and YANG, and blood stasis, expectorant are turbid, the stagnation of QI, YIN-cold are mark.Therefore Chinese traditional treatment is take blood circulation promoting and blood stasis dispelling, tonifying Qi and lifting yang as the rule for the treatment of.
The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine decoction of this treatment angina pectoris is made by the Chinese medicine of following weight portion: Radix Bupleuri 15-20 part, Radix Ophiopogonis 10-15 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Radix Aconiti Lateralis Preparata 15-25 part, Radix Codonopsis 9-13 part, Radix Rehmanniae Preparata 10-15 part, Radix Glycyrrhizae 15-20 part, Flos Carthami 10-15 part, Herba Leonuri 15-20 part, Radix Achyranthis Bidentatae 15-20 part, Radix Curcumae 10-15 part.
Preferably, the Chinese medicine decoction of this treatment angina pectoris is made by the Chinese medicine of following weight portion: 17 parts of Radix Bupleuri, 13 parts of Radix Ophiopogonis, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Aconiti Lateralis Preparatas, 11 parts of Radix Codonopsis, 13 parts of Radix Rehmanniae Preparata, 17 parts, Radix Glycyrrhizae, 13 parts, Flos Carthami, 17 parts of Herba Leonuris, 17 parts of Radix Achyranthis Bidentataes, 13 parts of Radix Curcumaes.
Above Chinese medicine is fried in shallow oil into decoction by traditional method.
In the side, Radix Bupleuri is evacuated and is brought down a fever, the yang invigorating soothing liver-QI; Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, the dampness diuretic; The Radix Aconiti Lateralis Preparata recuperating depleted YANG and rescuing the patient from collapse is mended fire supporing yang, dispersing cold for relieving pain; The Radix Codonopsis invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting; Radix Rehmanniae Preparata is enriched blood moist; The benefit essence is filled out marrow, Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; Flos Carthami invigorate blood circulation latus rectum, eliminating stasis to stop pain; The Herba Leonuri promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing; The Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening; Promoting blood circulation to restore menstrual flow, inducing diuresis for treating stranguria syndrome; The Radix Curcumae regulating qi to disperse stagnation, heart fire-clearing upset-relieving.
Clinical data
1, physical data
Selected case is all come in May, 2005 to 2007 year outpatient service in the October inpatient of self-institute.Totally 214 examples, be divided into treatment group and matched group at random, every group of 107 examples.In 100 routine treatment groups, male 56 examples, female's 51 examples, age 45-73 year, average 55.5 ± 3.65) year, the course of disease 2.5 months-7 years, average 5.5 years.In matched group 107 examples, male 59 examples, female's 48 examples, age 46-74 year, average 54.5 ± 3.25) year, the course of disease 3 months-7.5 years, average 6 years.Two groups of patients at sex, age coincident with severity degree of condition than difference not statistically significant (P＞0.05).Before treatment, two groups of comparison there was no significant differences of blood lipids index (P＞0.05) have comparability.
2, diagnosis and inclusive criteria
Selected case all is diagnosed as angina pectoris, diagnoses according to " the diagnosis of coronary heart disease reference standard " of whole nation revision, and electrocardiogram is shown with the myocardial ischemia performance and accounts for 90.5%.The dyslipidemia diagnostic criteria is worked out as follows with reference to dyslipidemia control suggestion [4] standard that national dyslipidemia Preventing Countermeasures seminar in 1997 works out: cholesterol (TC)＞5.0mmoI/L, triglyceride (TG＞1.7mmI/L, high density lipoprotein (HDL-C)＜0.8mmoI/L, low density lipoprotein, LDL＞3.18mmoI/L person is abnormal, and gets rid of liver, kidney disease.
3, Therapeutic Method
Treatment group: adopt Chinese medicine decoction of the present invention.1 dose of every day, decocting extracting juice, minute 2 decoction being taken warmly.Matched group: take sorbitrate 10mg, every day 3 times, or nitroglycerin 20mg adds in 250mL liquid, every day 1 dead point.
Two groups all treating for 3 weeks as a course for the treatment of, all treats for two groups and observe 2 two more than the course for the treatment of; The treatment group case is all withdrawn the treatment treating coronary heart disease and angina pectoris during front 3 days for the treatment of and treatment.The patient who has hypertension, diabetes in matched group all continues to take blood pressure lowering or hypoglycemic medicine, when two groups of cases if angina pectoris attacks occurs in treatment, give the storax pill for treating coronary heart disease sublingual administration, and record anginal attack times and take the consumption of storax pill for treating coronary heart disease.In treatment front and back and treatment, two groups of cases are regularly done weekly Electrocardioscopy, regularly make the situation of change of blood, routine urinalysis, blood fat and liver, renal function.
4, criterion of therapeutical effect
Produce effects: clinical symptom disappearance, or light and heavy degree alleviate 2 differential, integrated value is less more than 2/3, Electrocardioscopy recovers normal or normal range; Effectively: clinical symptoms obviously reduces, or light and heavy degree alleviate 1 differential, integrated value reduces 1/3-2/3, Electrocardioscopy ST section reduces or more than rise 0.5mV, the T ripple that mainly leads shoals (more than 25%), or the T ripple becomes uprightly by flat ripple, and chamber or intraventricular block improve; Invalid: clinical symptoms is unchanged, or integrated value only reduces 1/3, and Electrocardioscopy is without the improver; Increase the weight of: clinical symptoms increases the weight of before treating to some extent, and more than Electrocardioscopy ST section reduced 0.05VY than treatment is front, leading connection was inverted, or various ectopic cardiac rhythms occur.
5, therapeutic outcome
(1) general curative effect treatment group 107 examples, produce effects 48 examples (44.9%), effective 52 examples (48.6%), invalid 7 examples (6.5%), total effective rate 93.5%;
Matched group 107 examples, produce effects 29 examples (27.1%), effective percentage 57 examples (53.3%), invalid 21 examples (19.6%), total effective rate 80.4%.Relatively there were significant differences (P＜0.01) for two groups of patient's total effective rates.
(2) show effect weekly 11.85 ± 2.45 times before the treatment of angina pectoris attacks frequency treatment group, show effect weekly after treatment 4.25 ± 1.20 times; Show effect weekly before treatment of control group 11.80 ± 2.60 times, show effect weekly after treatment 6.65 ± 2.72 times, two groups of comparing differences have significant (P＜0.01).
After (3) two groups of treatments, ECG curative effect relatively: treatment group 100 examples, produce effects 31 examples (30.0%), effective 57 examples (53.3%), invalid 19 examples (17.8%), total effective rate 82.2%; Matched group 107 examples, produce effects 19 examples (17.8%), effective percentage 60 examples (56.1%), invalid 28 examples (26.2%), total effective rate 73.8%.Two groups relatively have significant difference (P＜0.05).
Before and after (4) two groups of treatments, the clinical symptoms integrated value changes relatively: be respectively 19.5 ± 5.80,7.0 ± 4.62 before and after the treatment group treatment; Be 18.5 ± 5.80,8.6 ± 4.75 before and after treatment of control group, before and after two groups of treatments, significant difference is arranged more all, but treatment group difference be more remarkable.
Any untoward reaction does not all appear in untoward reaction treatment group in whole therapeutic process and matched group has lighter headache, dizzy symptom after having 7 examples to take medicine, can spontaneous remission after lying up one hour, make regular check on liver, renal function simultaneously in therapeutic process all normal.
The specific embodiment
Embodiment one: get Radix Bupleuri 17g, Radix Ophiopogonis 13g, Rhizoma Atractylodis Macrocephalae 20g, Radix Aconiti Lateralis Preparata 20g, Radix Codonopsis 11g, Radix Rehmanniae Preparata 13g, Radix Glycyrrhizae 17g, Flos Carthami 13g, Herba Leonuri 17g, Radix Achyranthis Bidentatae 17g, Radix Curcumae 13g, above Chinese medicine is fried in shallow oil into decoction by traditional method.
Embodiment two: get Radix Bupleuri 15g, Radix Ophiopogonis 10g, Rhizoma Atractylodis Macrocephalae 25g, Radix Aconiti Lateralis Preparata 15g, Radix Codonopsis 9g, Radix Rehmanniae Preparata 15g, Radix Glycyrrhizae 15g, Flos Carthami 15g, Herba Leonuri 20g, Radix Achyranthis Bidentatae 20g, Radix Curcumae 10g, above Chinese medicine is fried in shallow oil into decoction by traditional method.
Embodiment two: get Radix Bupleuri 20g, Radix Ophiopogonis 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Aconiti Lateralis Preparata 25g, Radix Codonopsis 13g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 20g, Flos Carthami 10g, Herba Leonuri 15g, Radix Achyranthis Bidentatae 15g, Radix Curcumae 15g, above Chinese medicine is fried in shallow oil into decoction by traditional method.
Claims (1)
1. Chinese medicine decoction for the treatment of angina pectoris is characterized in that the Chinese medicine decoction of this treatment angina pectoris is made by the Chinese medicine of following weight: Radix Bupleuri 17g, Radix Ophiopogonis 13g, Rhizoma Atractylodis Macrocephalae 20g, Radix Aconiti Lateralis Preparata 20g, Radix Codonopsis 11g, Radix Rehmanniae Preparata 13g, Radix Glycyrrhizae 17g, Flos Carthami 13g, Herba Leonuri 17g, Radix Achyranthis Bidentatae 17g, Radix Curcumae 13g.
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| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
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| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
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| Title |
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| 刘财，侯凤茹，刘晓明.冠心病中医辨治５ 法.《长春中医药大学学报》.2010,第26卷(第6期),849. * |
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