CN102579013B - Traditional Chinese medicine pulse diagnosis apparatus - Google Patents

Abstract

The traditional Chinese medicine pulse diagnosis instrument of the present invention includes a pulse pillow box and a computer, and a pulse cutting groove is arranged on one side of the pulse pillow box, and a lifting mounting frame is arranged on the other side of the pulse pillow box, and the lifting mounting frame is an inverted "L" shape. Knee arm structure, its lower end is inserted in the pulse pillow box, and a stepping motor is connected below, and the stepping motor is controlled by a stepping motor controller; A data card shell and a data card are arranged in the middle of the frame, a test sensor and a compensation sensor mounting frame are set under the lifting mounting frame, and a test sensor array and a compensation sensor array are installed at the lower end of the mounting frame; the test sensor array and the compensation sensor The array is suspended above the vein cutting groove, and is connected with the input terminal of the data card through the wire, and the output end of the data card is connected with the computer through the connection wire or by bluetooth. The invention can obtain the accurate pulse wave information of the subject and provide decision-making basis for TCM treatment.

Description

Traditional Chinese Medicine Pulse Diagnosis Instrument

technical field

The invention relates to the technical field of testing instruments, and is a traditional Chinese medicine pulse diagnosis instrument based on the pulse-cutting principle in the four diagnostic methods of traditional Chinese medicine (look, smell, question and feel) and realized by sensors and computer technology.

technical background

"Looking, smelling, asking, and feeling" are the basic and important means of diagnosis in traditional Chinese medicine. Chinese medicine practitioners can understand the pulse information transmitted by the radial artery by "cutting"—signaling the pulse and applying pressure of different strengths on the fingertips (divided into: , deep, late, number, slippery, astringent, imaginary, solid, long, short, flood, slight, tight, slow, thick, string, leather, firm, wet, weak, loose, thin, volt, dynamic, rapid, knot , Daimai), the pulse condition of traditional Chinese medicine can be regarded as a synthesis of the pulse pressure applied by the doctor to the patient and the fluctuation information of the patient's own radial artery.

Any test instrument/instrument is tested under a certain background. When using each (instrument) test method, the interference of the background to the signal to be detected must be considered, and the background compensation and elimination must be taken into account. However, the relevant reports and patent documents on the development of the existing TCM pulse diagnosis instrument do not consider the compensation and elimination of the pulse test background.

The sensor is a key component of the test instrument, and also one of the key factors for the success of the development of the pulse diagnosis instrument. At present, there are two types of sensors used for pulse diagnosis in traditional Chinese medicine, one is an acoustic sensor, and the other is a force sensor. There are two commonly used force sensors: one is a force sensor made of ceramic membrane material, and the minimum size of the sensor is usually Ф18. The other is a (film-type) force sensor made of polymer material PVDF, and the minimum size of the sensor is usually Ф13. The force sensor will generate different potentials when it is subjected to different pressures, so it is also called a piezoelectric sensor. Since the overall width of the traditional Chinese medicine radial artery (cun, guan, chi pulse opening) is not greater than 5mm, and the length is not greater than 50mm, when the (film type) force sensor is used as the signal detection component of the traditional Chinese medicine pulse diagnosis instrument, the measured pulse wave and The mixed information of the peripheral muscle response, because the sensitivity of the film type force sensor is positively correlated with the contact (sensitive) area, if the sensor area is too small, its sensitivity is not enough; and when the size is larger than Ф5mm, the measured pulse wave information is not pure . At present, the pulse wave signal measured by the pulse diagnosis instrument designed with force sensor has only two waveforms: coming and going slowly and coming and going slowly, which cannot reproduce the 27 kinds of pulses in traditional Chinese medicine. are closely related.

"Pulse condition" is the embodiment of the activities of viscera in the concept of traditional Chinese medicine, and is the comprehensive information of the human body that is transmitted to the cun, guan, and chi parts through the meridians and collaterals. The transmission of any information contains the signal loss caused by the channel and the interference caused by the channel to the signal. Therefore, the breadth and accuracy of the signals generated by ultrasonic sensors when used in TCM pulse diagnosis are far lower than the information provided by B-ultrasound directly detecting viscera; in addition, ultrasonic sensors cannot realize floating, middle and sinking in TCM. Thereby it is basically impossible to implement on the industry that the sound sensor is used for the pulse diagnosis of traditional Chinese medicine. the

The physical size of radial artery (Cun, Guan, Chi pulse in medicine) is 5mm×50mm. In testing science, this area is defined as the target (system) of the test, and the corresponding area is called the background. Therefore, the maximum diameter of the sensitive part of the force sensor (including packaging and protection) should be less than 5mm. Whether the existing sensor size can meet this requirement is the key to the successful application of TCM pulse diagnosis instrument. At present, there is no force sensor smaller than Φ5 in China. Traditionally, pressure sensors are generally used to test gases and liquids. The existing domestic and foreign pressure sensors cannot realize the pressure test of solid systems in terms of manufacturing process and structure. Therefore, because the test unit of the existing TCM pulse diagnosis instrument designed based on the pressure sensor is the mechanical characteristics of the pulse wave fluctuation, it is impossible to verify whether these characteristics have a one-to-one correspondence with the TCM pulse condition.

In addition to the sensor, the key components of the test instrument include the data acquisition unit. Among the components of the traditional Chinese medicine pulse diagnosis instrument, the data acquisition unit is currently the most mature technology. It does not need to be re-researched and developed. As long as the positioning number, channel number or sampling frequency parameters are given, stable and reliable data can be obtained in the market. capture card. However, more than 65% of the research and development of a large number of pulse diagnosis instruments for traditional Chinese medicine in recent years describe the development of data cards. Since they do not have clear relevant technical parameters when selecting sensors, there is no good and clear integration concept in terms of sensitivity, stability, linearity, time constant, etc. during the entire instrument integration process, and the corresponding use effects will be affected.

Contents of the invention

The purpose of the present invention is to solve the problems existing in the above existing TCM pulse diagnosis instrument, and provide a TCM pulse diagnosis instrument based on strain gauge type and improved pressure sensor.

In order to achieve the above object, the technical scheme that the present invention takes is:

A traditional Chinese medicine pulse diagnosis instrument, comprising a pulse pillow box and a computer, the pulse pillow box is connected to the computer through a connecting wire; it is characterized in that a pulse cutting groove is arranged on the top surface of the pulse pillow box, and The other side is provided with a lifting mounting frame, the lifting mounting frame is an inverted "L" shaped crank arm structure, the lower end of which is inserted into the pulse pillow box, and the lower end of the lifting mounting frame is connected with a stepping motor, and the stepping motor Set on the bottom plate in the pulse pillow box, controlled by a stepper motor controller set on one side of the pulse pillow box; a respiratory gating test system is installed on the horizontal arm of the lifting installation frame, The first data card, the second data card and the third data card are installed in the middle area inside the arm, and a test sensor mounting frame and a compensation sensor mounting frame are arranged under the horizontal crank arm of the lifting mounting frame, and the lower end of the testing sensor mounting frame A test sensor array is installed, and a compensation sensor array is installed on the lower end of the compensation sensor mounting frame; the sensors in the test sensor array and the compensation sensor array are composed of sensor chips, protective screens and packaging shells; the test sensor array and the compensation sensor array are suspended above the vein cutting groove, and they are connected with the input terminals of the first data card, the second data card and the third data card through wires, and the first data card, the second data card and the third data card The output end of the card is connected with the computer through the USB interface or in the bluetooth mode.

Further, the test sensor array and the compensation sensor array are integrated by individually packaged sensor units, or are packaged uniformly by integrated sensors.

The test sensor array and the compensation sensor array are sensor arrays with no less than 3 columns and no less than 20 rows uniformly arranged in a rectangle of 5 mm×50 mm.

The test sensor array applies a force of 20, 40, 60, 80, 100, 120, 140, 180, 200N to the cun, guan, and chi pulses of the human wrist to convert the pulse wave signal into an electrical signal.

The compensation sensor array is used to measure the influence of the environment on the pulse wave, including the influence of temperature and non-physiological factors of the subject's movement, and provide compensation and reference for the actual pulse wave signal.

The independently packaged sensor unit includes a semiconductor piezocapacitive sensor and a resistance strain gauge sensor.

The packaging shell of the independently packaged semiconductor pressure capacitive sensor is 0.2-7.0mm higher than the sensor chip, and the material of the packaging shell is aluminum alloy.

The packaging casing of the independently packaged resistance strain gauge sensor is 0.2-7.0mm higher than the sensor chip, and the packaging casing is made of organic resin.

Further, each protective screen of the independently packaged sensor unit is structurally independent, the top surface of the protective screen is higher than the top surface of the packaging shell, the bottom surface of the protective screen is directly bonded to the sensor chip, and the protective screen The sides of the sensor are not in contact with the inner wall of the package to ensure the independence and linearity of the signals of each sensor unit.

The size of the structure of the protective screen of the sensor chip is determined by the parameters of the sensor, the elastic modulus E and density ρ of the protective screen material, the natural frequency nf ₀ of the sensor, and the height difference between the package shell and the sensor chip. The range of difference is 0.21-8.0mm.

The protective screen is made of elastic material, and the elastic material is silica gel or rubber.

The positive effect of the Chinese medicine pulse diagnosis instrument of the present invention is:

Considering that TCM pulse (inch, guan, mouth) measures the dynamic cycle information of the pulse condition within the area of 5mm×50mm, it is necessary to distinguish the delay, slowness and number of the pulse condition in the time dimension, and the length and shortness of the pulse condition in the space dimension. In terms of intensity, it is necessary to distinguish virtual, micro, real, and flood pulse conditions, and in terms of spatial distribution, it is necessary to distinguish pulse conditions such as sputum, string and thin pulse conditions. The present invention first determines the conversion principle of the sensor, and stipulates that the size of the sensor is less than 0.3mm× 1.4mm, using two kinds of sensor packaging materials and integration methods; use silica gel or neoprene as the packaging material to prepare 1mm×3mm～5mm×20mm arrays of pulse diagnosis instrument sensors (pressure capacitive and piezoresistive), using The respiratory gating system matches and corrects the pulse wave signal, so that accurate pulse wave information of the subject can be obtained, which provides a decision-making basis for pulse diagnosis in traditional Chinese medicine.

Description of drawings

Fig. 1 is the structural representation of the pulse diagnosis instrument of traditional Chinese medicine of the present invention;

Fig. 2 is the sectional view of A-A in Fig. 1;

Fig. 3 is the working principle diagram of the traditional Chinese medicine pulse diagnosis instrument of the present invention;

Figure 4 Schematic diagram of sensor array;

Figure 5 is a top view of the sensor package surface in contact with the wrist;

Figure 6 is a cross-sectional view of the sensor package in contact with the wrist;

Figure 7 Schematic diagram of sensor array and compensation sensor setup position (5 mm×50 mm);

Figure 8 Matching diagram of breathing cycle and pulse cycle;

Fig. 9 is a schematic diagram of the workflow of the traditional Chinese medicine pulse diagnosis instrument of the present invention;

The pulse wave signal of a volunteer measured in Fig. 10 embodiment 1;

Fig. 11 The pulse wave signal of a volunteer measured in Example 2 (Cun Shui Guan Shi);

The pulse wave signal diagram of a certain volunteer measured in Fig. 12 embodiment 3;

Fig. 13 The pulse port corresponding to the sensor array channel used in embodiment 3;

The pulse wave signal of a certain volunteer measured in Fig. 14 embodiment 4;

Fig. 15 The autocorrelation diagram of a pulse wave signal of a certain path in Embodiment 5;

Fig. 16 The cross-correlation figure of certain two pulse wave signals of embodiment 6;

Fig. 17 The pulse wave signal of the central point of Cunmai (astringent pulse) in Example 7;

Fig. 18 The pulse wave signal of the central point of Cunmai (Huamai) in Example 8;

Fig. 19 The pulse wave signal (芤脉) measured in embodiment 9;

Fig. 20 The pulse wave signal (solid pulse) of the center point of the 10-inch pulse in embodiment 10;

Fig. 21 The pulse wave signal (small vein) of the 11-inch pulse cross-section in the embodiment;

Figure 22 Schematic diagram of the shape of the protective screen.

The labels in the figure are:

1. Test sensor array; 2. Test sensor mounting frame; 3. Horizontal crank arm; 311. First data card;

312. The second data card; 313. The third data card; 4. The respiratory gating test system; 5. The lifting installation frame;

6. Stepper motor; 61. Stepper motor controller; 7. Computer; 8. Compensation sensor array;

9. Compensation sensor mounting frame; 10. Pulse pillow box; 11. Vein cutting groove; 12. Protective screen;

13. Sensor chip; 14. Encapsulation shell.

Detailed ways

The specific implementation manners of the TCM pulse diagnosis instrument of the present invention will be explained below in conjunction with the accompanying drawings. It should be noted that the implementation of the present invention is not limited to the following implementation manners.

See accompanying drawings 1 and 2. A traditional Chinese medicine pulse diagnosis instrument comprises a pulse pillow box 10 and a computer 7 . The pulse pillow case 10 is a box-shaped structure, and a vein-cutting groove 11 is set on the top surface of the pulse pillow case 10. The size of the pulse-cutting groove 11 should be able to place the measured person's wrist in the groove. On the other side of the pulse pillow box 10 relative to the pulse cutting groove 11, a lifting installation frame 5 is arranged. The lifting mounting frame 5 is an inverted "L" shaped crank arm structure, its lower end is inserted in the pulse pillow box 10, and a stepping motor 6 is connected to the bottom end of the lifting mounting frame 5, and the stepping motor 6 Be fixed on the bottom plate in the pulse pillow box 10 with bolts, and be controlled by the stepping motor controller 61 that is arranged on the pulse pillow box 10 side. Above the horizontal crank arm 3 of the lifting installation frame 5, the respiratory door control test system 4 is fixedly installed with screws; the first data card 311, the second data card 312 and the third data card are installed in the inner middle area of the horizontal crank arm 3 313: Install a test sensor mounting frame 2 and a compensation sensor mounting frame 9 in a welding manner below the horizontal crank arm 3, and install a test sensor array 1 at the lower end of the test sensor mounting frame 2, that is, the test sensor array 1 is fixed on the lower end of the test sensor installation frame 2 with screws, and the sensor wires are connected to the input terminals of the first data card 311, the second data card 312 and the third data card 313 through the inside of the test sensor installation frame 2. The compensation sensor array 8 is installed at the lower end of the compensation sensor mounting frame 9, that is, the compensation sensor array 8 is fixed on the lower end of the compensation sensor mounting frame 9 with screws, and the sensor wire passes through the inside of the compensation sensor mounting frame 9 and the first data card 311, The input terminals of the second data card 312 and the third data card 313 are connected. The test sensor array 1 and the compensation sensor array 8 are suspended above the vein cutting groove 11, and they communicate with the first data card 311, the second data card 312 and the third data card 311 through wires (installed in the mounting frame) The input terminal of the data card 313 is connected, and the output terminals of the first data card 311 , the second data card 312 and the third data card 313 are connected to the computer 7 through a USB interface or in a bluetooth manner.

In practice, the test sensor array 1 and the compensation sensor array 8 used are integrated by individually packaged sensor units, or are uniformly packaged by integrated sensors (see FIG. 5 and FIG. 6 ). The test sensor array 1 and the compensation sensor array 8 should be uniformly arranged in a rectangle of 5 mm×50 mm, and the mode of setting is a sensor array with no less than 3 columns and no less than 20 rows (see FIG. 4 ). The sensors in the test sensor array 1 are composed of a sensor chip 13 , a protective screen 12 and a packaging shell 14 . The test sensor array 1 can apply force of 20, 40, 60, 80, 100, 120, 140, 180, 200N to the Cun, Guan and Chi pulses of the human wrist to convert the pulse wave signal into an electrical signal. The compensation sensor array 8 can be used to measure the influence of the environment on the pulse wave, including the influence of temperature and non-physiological factors of the subject's movement, and provide compensation and reference for the actual pulse wave signal.

The aforementioned "independent packaging" means that the protective screens 12 of each sensor unit are structurally independent, so as to ensure the independence and linearity of the signals of each sensor unit. The independently packaged sensor unit includes a semiconductor piezocapacitive sensor and a resistance strain gauge sensor. The technical parameter range of the semiconductor pressure capacitive pressure sensor used is shown in Table 1:

Table 1. Technical parameter range of semiconductor pressure capacitive pressure sensor

。

.

The range of technical parameters of the resistance strain gauge sensor used is shown in Table 2:

Table 2. Technical parameter range of resistance strain gauge sensor

.

In practice, the package shell 14 of the independently packaged semiconductor piezocapacitive sensor should be 0.2 mm to 7.0 mm higher than the sensitive surface of the sensor chip 13 (see h ₁ in Figure 6), and the material of the package shell 14 is aluminum alloy. The packaging case 14 of the independently packaged resistance strain gauge type sensor is 0.2 mm to 7.0 mm higher than the sensor chip 13 (see h ₁ in Figure 6), and the material of the packaging case 14 is organic resin: such as phenolic resin or polyester imide resin.

In practice, the structure of the protective screen 12 used is as shown in FIG. 22 , but it is not limited to such a structure. Each protective screen 12 is structurally independent. Different from the packaging and protection screen design methods of traditional force sensors, the top surface of the protection screen 12 of the present invention is higher than the top surface of the packaging shell 14, and the bottom end surface of the protection screen 12 is directly bonded on the sensor chip 13. The side faces are not in contact with the inner walls of the packaging case 14 . During centralized packaging, the side walls of the protective screens 12 of the sensor units are not in contact with each other, so as to ensure the independence and linearity of the signals of each sensor unit. The protective screen 12 of the independently packaged semiconductor piezocapacitive sensor and the independently packaged resistance strain gauge sensor is made of elastic materials such as silica gel or rubber. The purpose of packaging with the protective screen 12 and the packaging shell 14 is to ensure that the applied force (excitation) exceeds the burst pressure described in Table 1 and Table 2 to avoid damage to the sensor or to prevent the sensor from slipping during the test. The test sensor array 1 and the compensation sensor array 8 can effectively transmit signals.

During implementation, the cross-sectional view of the protective screen 12 of each sensor unit in the test sensor array 1 is shown in Figure 6, and the range of its size is:

L ₁ : L ₂ : L ₃ = 1:0.8:0.6～1:0.9:0.8 (unit: mm)

_h2 = 0.21mm～8.0mm

The cross-sectional view of the protective screen 12 of each sensor unit in the compensation sensor array 8 is shown in Figure 6, and the range of its size is:

L ₁ : L ₂ : L ₃ =1:0.8:0.6 ～1:0.9:0.8 (unit: mm)

_h2 = 0.21mm～8.0mm

The compensation sensor array 8 is set at the inner side of the arm at the apex of the isosceles triangle with the test sensor array 1 as the base, and the angle α is 80-130° (see FIG. 7 ).

The test sensor array 1 and the compensation sensor array 8 convert electrical signals into data signals after filtering and amplifying: A/D 10-14 bits, 3×5-5×50 channels; data collection and transmission The frequency range is: 40 ~ 80HZ.

The pulse wave information collected by the respiratory gating system 4 determines the starting point T ₁ and the ending point T ₂ of a breathing cycle time, taking the start time of inhalation as the starting point T ₁ , and taking the end time of exhalation as the ending point T ₂ of a breathing cycle (See Figure 8).

When in use, the operator can issue instructions through the computer 7, control the stepper motor 6 through the stepper motor controller 61, move the test sensor array 1 and the compensation sensor array 8 to the top of the pulse cutting groove 11 and press on the wrist radial artery of the subject. At a suitable position (see FIG. 7 ), the test sensor array 1 and the compensation sensor array 8 apply a specified pressure to the radial artery of the subject; at this time, the first data card 311, the second data card 312 and the third data card 313 Collect the signals generated by the test sensor array 1 and the compensation sensor array 8, and then through the internal amplification, filtering and analog-to-digital conversion of the first data card 311, the second data card 312 and the third data card 313, through the USB interface or in the form of Bluetooth It is connected with computer 7, and the test process is completed by computer 7. See accompanying drawing 3 for its specific working principle.

Several specific examples are provided below.

Example 1

A traditional Chinese medicine pulse diagnosis instrument, its structure, connection and installation methods are as described above. Further explanation here is:

3.90mm，保护屏12尺寸与传感器芯片13尺寸的比例关系为L₁: L₂: L₃ =1: 0.9: 0.8，保护屏12上下两个面的尺寸为：下底面1.26mm×0.27mm，上顶面1.12mm×0.24mm。选用硅胶（弹性模量E=2.14MPa，密度ρ=1.19～1.35g/cm³）为保护屏12的材料，传感器的固有频率=1000f ₀（f ₀为脉搏跳动频率，一般取1/1.2s^-1）。中医脉诊仪的具体工作流程参见附图9。在20N压力激励下测得的某志愿者的脉波如图10所示。需要说明的是：保护屏12的形状不限于本实施例所述的形状。 The dimensions of the test sensor array 1 and the compensation sensor array 8 are both 1.4 mm×0.3 mm, corresponding to h ₁ =3 mm in FIG. 6 ,

3.90mm, the proportional relationship between the size of the protective screen 12 and the size of the sensor chip 13 is L ₁ : L ₂ : L ₃ =1: 0.9: 0.8, the size of the upper and lower sides of the protective screen 12 is: the lower bottom surface 1.26mm×0.27mm, The upper top surface is 1.12mm×0.24mm. Select silica gel (elastic modulus E=2.14MPa, density ρ=1.19～1.35g/cm ³ ) as the material of the protective screen 12, and the natural frequency of the sensor=1000 f ₀ ( f ₀ is the pulse beating frequency, generally 1/1.2 s ^-1 ). See accompanying drawing 9 for the specific workflow of the pulse diagnosis instrument of traditional Chinese medicine. The pulse wave of a volunteer measured under 20N pressure excitation is shown in Figure 10. It should be noted that the shape of the protective screen 12 is not limited to the shape described in this embodiment.

Example 2

2.6mm，保护屏12尺寸与传感器芯片13尺寸的比例关系为L₁:L₂:L₃ = 1:0.9:0.75，保护屏12上下两个面的尺寸为：下底面1.26mm×0.27mm，上顶面1.05mm×0.23mm。传感器整体封装，选用硅胶（弹性模量E=2.14MPa，密度ρ=1.19～1.35g/cm³）为保护屏12的材料，传感器的固有频率=1000f ₀（f ₀为脉搏跳动频率，一般取1/1.2s^-1）。在100N压力激励下测得的某志愿者的脉波如图11所示。 The difference between embodiment 2 and embodiment 1 is that: 6 resistance strain gauge sensor arrays are used, the array is evenly distributed (2 rows × 3 columns), the row spacing is 2.8mm, and the column spacing is 0.8mm. The size is 1.4mm×0.3mm, corresponding to h ₁ =2mm in Figure 6,

2.6mm, the proportional relationship between the size of the protective screen 12 and the size of the sensor chip 13 is L ₁ : L ₂ : L ₃ = 1:0.9:0.75, the size of the upper and lower sides of the protective screen 12 is: the lower bottom surface 1.26mm×0.27mm, The upper top surface is 1.05mm×0.23mm. The sensor is packaged as a whole, using silica gel (elastic modulus E=2.14MPa, density ρ=1.19～1.35g/cm ³ ) as the material of the protective screen 12, and the natural frequency of the sensor=1000 f ₀ ( f ₀ is the pulse beating frequency, generally Take 1/1.2s ^-1 ). The pulse wave of a volunteer measured under 100N pressure excitation is shown in Figure 11.

Example 3

1.10mm，保护屏12尺寸与传感器芯片13尺寸的比例关系为L₁:L₂:L₃ = 1:0.85:0.85，保护屏12上下两个面的尺寸为：下底面1.19mm×0.26 mm，上顶面1.19×0.26 mm。每个传感器单独封装，选用丁基橡胶（弹性模量E=7.8MPa，密度ρ=0.92g/cm³）为保护屏12的材料，传感器的固有频率=1000f ₀（f ₀为脉搏跳动频率，一般取1/1.2s^-1）。在200N压力激励下测得的某志愿者的脉波如图12所示，传感器阵列与对应的脉口位置如图13所示。 The difference between embodiment 3 and embodiment 1 is that 24 resistance strain gauge sensor arrays are used, the array is evenly distributed (6 rows×4 columns), the row spacing is 2.8mm, and the column spacing is 0.8mm. The size is 1.4mm×0.3 mm, corresponding to h ₁ =1mm in Figure 6,

1.10mm, the proportional relationship between the size of the protective screen 12 and the size of the sensor chip 13 is L ₁ : L ₂ : L ₃ = 1:0.85:0.85, the size of the upper and lower sides of the protective screen 12 is: the lower bottom surface 1.19mm×0.26 mm, The upper top surface is 1.19×0.26 mm. Each sensor is individually packaged, butyl rubber (elastic modulus E=7.8MPa, density ρ=0.92g/cm ³ ) is selected as the material of the protective screen 12, and the natural frequency of the sensor is 1000 f ₀ ( f ₀ is the pulse beating frequency , generally take 1/1.2s ^-1 ). The pulse wave of a volunteer measured under 200N pressure excitation is shown in Figure 12, and the sensor array and the corresponding pulse port position are shown in Figure 13.

Example 4

2.6mm，保护屏12尺寸与传感器芯片13尺寸的比例关系为L₁: L₂: L₃ =1: 0.9: 0.75，保护屏12上下两个面的尺寸为：下底面1.26mm×0.27mm，上顶面1.05mm×0.23mm。每个传感器单独封装，选用硅胶（弹性模量E=2.14MPa，密度ρ=1.19～1.35g/cm³）为保护屏的材料，传感器的固有频率=1000f ₀（f ₀为脉搏跳动频率，一般取1/1.2s^-1）。在100N压力激励下测得的某志愿者的脉波如图14所示。 The difference between embodiment 4 and embodiment 1 is that 126 strain gauge sensor arrays are used, and the array is evenly distributed (2 rows×3 columns), with a row spacing of 2.8 mm and a column spacing of 0.8 mm. The size of each sensor is 1.4mm×0.3mm, corresponding to h ₁ =2mm in Figure 6,

2.6mm, the proportional relationship between the size of the protective screen 12 and the size of the sensor chip 13 is L ₁ : L ₂ : L ₃ =1: 0.9: 0.75, the size of the upper and lower sides of the protective screen 12 is: the lower bottom surface 1.26mm×0.27mm, The upper top surface is 1.05mm×0.23mm. Each sensor is individually packaged, using silica gel (elastic modulus E=2.14MPa, density ρ=1.19～1.35g/cm ³ ) as the material of the protective screen, the natural frequency of the sensor = 1000 f ₀ ( f ₀ is the pulse beating frequency, Generally take 1/1.2s ^-1 ). The pulse wave of a volunteer measured under 100N pressure excitation is shown in Figure 14.

Example 5

With the pulse wave signal of a certain volunteer measured by the sensor array described in embodiment 2, a certain path signal f ( t ) is carried out autocorrelation analysis, and described autocorrelation function The calculation process is as follows:

The "*" in it represents the convolution operator.

The autocorrelation function diagram of a pulse wave signal f ( t ) of a volunteer calculated according to the above formula is shown in Fig. 15 .

Example 6

的计算过程如下： Using the pulse wave signal of a volunteer measured by the sensor array described in embodiment 2, a certain two pulse wave signals f ₁ ( t ) and f ₂ ( t ) are subjected to cross-correlation analysis, and the cross-correlation function

The calculation process is as follows:

The "*" in it represents the convolution operator.

The cross-correlation function diagram of two channels of pulse signals f ₁ ( t ) and f ₂ ( t ) calculated according to the above formula is shown in Fig. 16 .

Example 7

The difference between Embodiment 7 and Embodiment 1 is that: 24 resistance strain gauge sensor arrays are used, each sensor has a size of 1.4×0.3 mm, and the array is uniformly distributed: 6 rows×4 columns, and the row spacing is 2.8mm. The row distance is 0.8mm; the pulse wave at the center of the Cun pulse of volunteer A after position correction measured under 140N pressure (sinking) is shown in Figure 17. : Thin, late, short, astringent, hard to come and go, loose and stop vaguely between the fingers; like rain and sticky sand, it is easy to disperse, and the disease eats away at the leaves slowly and hard.) Difficult; slightly like a second awn and slightly thin, ups and downs are not inseparable). Because there are 4 pulse waves in each respiratory cycle, the pulse wave shows a weak and slow feature when it is taken.

Example 8

The difference between Embodiment 8 and Embodiment 1 is that: 24 resistance strain gauge sensor arrays are used, the size of each sensor is 1.4×0.3 mm, and the array is evenly distributed: 6 rows×4 columns, and the row spacing is 2.8mm. The column distance is 0.8mm; the pulse wave of the Cunmai center point of volunteer B measured under the pressure of 60N after position correction is shown in Figure 18. Volunteer B’s pulse condition is Huamai (There is a poem about the body shape that says: Huamai is like a pearl, it flows smoothly but still moves forward; don’t count slippery pulses as the same type, only see the number of pulses.) slippery is like a pearl, The number is six to.

Example 9

The difference between Embodiment 9 and Embodiment 1 is that: 24 resistance strain gauge sensor arrays are used, each sensor has a size of 1.4×0.3mm, and the array is evenly distributed: 6 rows×4 columns, and the row spacing is 2.8mm. The column distance is 0.8mm; the pulse wave of volunteer C measured under 60N pressure is shown in Figure 19. C Volunteer’s pulse condition belongs to the sputum pulse (there is a poem about the shape of the scallion: the shape of the scallion is as big as a green onion, and the edge is real, so you must know that the inside is empty; the fire invades the yang and the blood overflows, and the heat invades the yin collaterals and flows red.) (similar poems are: The hollow next to it is actually a scallion, which is large and slows the empty pulse; the scallion is also called leather with strings, and the scallion is blood loss leather and blood deficiency).

Example 10

The difference between Embodiment 10 and Embodiment 1 is that 24 resistance strain gauge sensor arrays are used, and the size of each sensor is 1.4×0.3 mm, and the array is uniformly distributed: 6 rows×4 columns, and the row spacing is 2.8mm. The column distance is 0.8mm; the pulse wave at the center of Cunmai center of volunteer D measured under 10N pressure is shown in Figure 20 after position correction. D Volunteer’s pulse condition belongs to the real pulse (there is a body-like poem saying: both ups and downs are large and long, which should mean that there is no false amplitude and strong; heat accumulates in the triple burner to form a strong fire, and the intestines are sweating to be healthy.) (similar poems are: real The pulse fluctuates and is powerful and strong, as tight as a elastic rope and turns impermanent; it should be noted that the pulse helps the muscles and bones, and the solid big and small strings are longer).

Example 11

The difference between Embodiment 11 and Embodiment 1 is that: 25 semiconductor piezocapacitive sensor arrays are used, the size of each sensor is 0.8×0.8 mm, and the array is evenly distributed: 5 rows×5 columns, and the row spacing is 0.2mm. The column distance is 0.2mm; the pulse waves of E volunteers in the Cunmai cross section (y=0) measured under 40N pressure are shown in Figure 21. Volunteer E’s pulse condition is thready (there is a poem about the shape of the veins: “Thin to numerous and thin like silk, it should mean deep and endless; spring and summer are unfavorable for teenagers, but autumn and winter are suitable for old and weak).

The above is only a preferred embodiment of the present invention, and it should be pointed out that for those of ordinary skill in the art, without departing from the structure and method of the present invention, some improvements and modifications can also be made. These improvements and Retouching should also be considered within the protection scope of the present invention.

Claims (10)

1. A traditional Chinese medicine pulse diagnosis instrument, comprising a pulse pillow box (10) and a computer (7), and the pulse pillow box (10) is connected to the computer (7) by a connecting wire; it is characterized in that, in the pulse pillow box (10) is provided with a cutting groove (11) on the top surface, and a lifting mounting frame (5) is provided on one side of the pulse pillow box (10), and the lifting mounting frame (5) is an inverted "L" shape Knee arm structure, the lower end of which is inserted into the pulse pillow box (10), the lower end of the lifting installation frame (5) is connected with a stepping motor (6), and the stepping motor (6) is arranged in the pulse pillow box (10) on the bottom plate of the pulse pillow box (10) and is controlled by a stepper motor controller (61); a respiratory gating test system (4 ), the first data card (311), the second data card (312) and the third data card (313) are installed in the middle area inside the horizontal crank arm (3) of the lifting installation frame (5). 5) A test sensor mounting frame (2) and a compensation sensor mounting frame (9) are provided under the horizontal crank arm (3), and a test sensor array (1) is installed at the lower end of the test sensor mounting frame (2). A compensation sensor array (8) is installed at the lower end of the compensation sensor mounting bracket (9); the sensors in the test sensor array (1) and the compensation sensor array (8) are composed of a sensor chip (13), a protective screen (12) and a packaging shell (14); the test sensor array (1) and the compensation sensor array (8) are suspended above the vein cutting groove (11), and they communicate with the first data card (311), the second data card (311) and the second The input terminals of the data card (312) and the third data card (313) are connected, and the output terminals of the first data card (311), the second data card (312) and the third data card (313) are connected through the USB interface or Bluetooth way to connect with computer (7). 2. The traditional Chinese medicine pulse diagnosis instrument according to claim 1, characterized in that, the test sensor array (1) and the compensation sensor array (8) are integrated by individually packaged sensor units, or integrated The sensors are packaged uniformly. 3. The traditional Chinese medicine pulse diagnosis instrument according to claim 2, characterized in that, the test sensor array (1) and the compensation sensor array (8) are not evenly arranged in a rectangle of 5 mm×50 mm. A sensor array with less than 3 columns and no less than 20 rows. 4. The traditional Chinese medicine pulse diagnosis instrument according to claim 3, characterized in that, the test sensor array (1) is applied to the human body with a force of 20, 40, 60, 80, 100, 120, 140, 180, 200N The Cun, Guan and Chi pulses of the wrist convert the pulse wave signal into an electrical signal. 5. The traditional Chinese medicine pulse diagnosis instrument according to claim 2, characterized in that the compensation sensor array (8) is used to measure the influence of the environment on the pulse wave, including the influence of temperature and non-physiological factors of the subject's movement, Provide compensation and reference to the actual pulse wave signal. 6. The pulse diagnosis instrument for traditional Chinese medicine according to claim 2, wherein the independently packaged sensor unit includes a semiconductor piezocapacitive sensor and a resistance strain gauge sensor. 7. The traditional Chinese medicine pulse diagnosis instrument according to claim 6, characterized in that, the packaging shell (14) of the independently packaged semiconductor piezocapacitive sensor is 0.2-7.0mm higher than the sensitive surface of the sensor chip (13), and the packaging The material of shell (14) adopts aluminum alloy. 8. The traditional Chinese medicine pulse diagnosis instrument according to claim 6, characterized in that, the packaging shell (14) of the independently packaged resistance strain gauge sensor is 0.2-7.0 mm higher than the sensitive surface of the sensor chip (13), and the packaging The material of the shell (14) adopts organic resin. 9. The traditional Chinese medicine pulse diagnosis instrument according to claim 2, characterized in that, each protective screen (12) of the independently packaged sensor unit is independent in structure, and the top surface of the protective screen (12) Higher than the top surface of the package shell (14), the bottom surface of the protective screen (12) is directly bonded to the sensitive surface of the sensor chip (13), and the side of the protective screen (12) does not contact the inner wall of the package shell (14) , to ensure the independence and linearity of each sensor unit signal. 10. The traditional Chinese medicine pulse diagnosis instrument according to claim 9, characterized in that, the size of the structure of the protective screen (12) of the sensor chip is determined by the parameters of the sensor, the elastic modulus E and density ρ of the protective screen material, the sensor The natural frequency nf ₀ of the sensor chip (13) is determined by the natural frequency nf 0 and the height difference between the package shell (14) and the sensitive surface of the sensor chip (13), and the range of the height difference is 0.21-8.0mm.

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