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CN102552416B - Traditional Chinese medicine granule for treating metabolic syndrome and habitual constipation - Google Patents

Traditional Chinese medicine granule for treating metabolic syndrome and habitual constipation Download PDF

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CN102552416B
CN102552416B CN 201210033818 CN201210033818A CN102552416B CN 102552416 B CN102552416 B CN 102552416B CN 201210033818 CN201210033818 CN 201210033818 CN 201210033818 A CN201210033818 A CN 201210033818A CN 102552416 B CN102552416 B CN 102552416B
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chinese medicine
traditional chinese
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habitual constipation
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张彬
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Abstract

The invention relates to a preparation method of a traditional Chinese medicine granule for treating metabolic syndrome and habitual constipation, which belongs to the traditional Chinese medicine preparation field. The effective components of the granule is composed of 30-60 parts of lotus leaf, 10-12 parts of wild chrysanthemum flower and 10-12 parts of Rhodiola rosea by weight ratio. The traditional Chinese medicine granule has the advantages of short administration treatment course, high treatment efficiency and high cure rate, administration of four months treatment courses can obviously reduce the body weight, and the blood fat is normal, the atherosclerotic plaque is smaller and stable, the effective rate of treatment can reach 94%, the recovery rate can reach 88%, and the traditional Chinese medicine granule has the advantages of stable curative effect and difficult recurrence.

Description

A kind of instant particles as Chinese medicine for the treatment of metabolism syndrome and habitual constipation
Technical field
The present invention relates to a kind of instant particles as Chinese medicine for the treatment of metabolism syndrome and habitual constipation, belong to field of traditional Chinese.
Background technology
Metabolism syndrome (metabolic syndrome, MS) be one group with obesity, hyperglycemia (diabetes or IGR), dyslipidemia (refer to hypertriglyceridemia and/or low-density lipoprotein cholesterol mass formed by blood stasis and hypertension etc. assemble morbidity), have a strong impact on the clinical syndrome of body health, it is the combination of one group of risk factor that is mutually related in metabolism, these factors have directly promoted the generation of atherosclerotic cardiovascular and cerebrovascular disease, have also increased the risk that type Ⅱdiabetes mellitus occurs.Result of study shows at present, and MS patient is the high-risk group that cardiovascular and cerebrovascular disease occurs, and with non-MS person, compares, and it suffers from the danger of cardiovascular and cerebrovascular disease and the danger of generation type Ⅱdiabetes mellitus all significantly increases.The morbidity of MS is the process of chronic a, progressivity, as easy as rolling off a log being failed to pinpoint a disease in diagnosis in clinical position, mostly enter the intermediary and later stages while by the time being found: the concomitant diseases such as type Ⅱdiabetes mellitus, chronic kidney disease, cardiovascular disease (as coronary heart disease, atherosclerosis etc.), hypertension have all occurred, cause the treatment of MS more difficult.Along with the acceleration of global aging, the prevalence of MS is ascendant trend year by year in recent years, and MS has become one of main disease of modern society's harm humans health, and the research of relevant MS also is subject to various countries scholar's attention.Habitual constipation refers to long-term, chronic functional constipation.Be mainly that the reasons such as the change of life, diet and bowl evacuation habit and psychological factor cause, rely on for a long time cathartic and only can increase the weight of gradually the constipation degree.The reason that hyperlipemia occurs is that toxin is too much; toxin in blood vessel comprises too much saturated fat class, too much monosaccharide, too much chemical substance etc.; these materials are in the deposition of blood vessel wall; it is angiosclerotic beginning; harmful material constantly deposits, body lacks enough abilities and removes these toxin; blood vessel is constantly encroached on, but can not get enough protective materials, is keeped in repair, and has just formed with the passage of time sclerosis.Therefore, the method for solution need be set about from root.
Summary of the invention
The technical problem to be solved in the present invention is: overcome the deficiencies in the prior art, a kind of instant particles as Chinese medicine for the treatment of metabolism syndrome and habitual constipation is provided, this instant particles as Chinese medicine taking convenience, and short treating period, have no side effect, and is easy to be accepted by the patient.
The technical solution adopted for the present invention to solve the technical problems is: the instant particles as Chinese medicine for the treatment of metabolism syndrome and habitual constipation, it is characterized in that, the raw material of this effective ingredient is comprised of Folium Nelumbinis, Flos Chrysanthemi Indici and Radix Rhodiolae, its weight proportion is 30~60 parts, Folium Nelumbinis, 10~12 parts of Flos Chrysanthemi Indicis, 10~12 parts of Radix Rhodiolaes.
Preferably, the raw material of this effective ingredient composition and weight proportion thereof are: 50 parts, Folium Nelumbinis, 10 parts of Flos Chrysanthemi Indicis, 12 parts of Radix Rhodiolaes.
In the present invention, each main effect that forms medicine is as follows: Folium Nelumbinis contains nuciferine, miltanthin and nuciferine and vitamin C, polysaccharide, bitter and puckery flavor; Folium Nelumbinis is flat, function heat-clearing and toxic substances removing, sending up the lucid YANG, the effect of cooling blood for hemostasis.Flos Chrysanthemi Indici, containing multiple volatile oil, comprises lauro lene, Eucarvone, limonene, also contains linarin, luteolin glycoside, Chrysanthemin, chrysanthemaxanthin, polysaccharide, Coumarins, yejuhua lactone; The Flos Chrysanthemi Indici cold nature, acrid in the mouth, hardship, the function heat-clearing and toxic substances removing, the dispelling wind suppressing the hyperactive liver, detumescence, all have inhibitory action to staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, influenza virus.Radix Rhodiolae sweet in the mouth, hardship, property is flat, returns lung, heart channel.The function benefiting QI for activating blood circulation, promote blood circulation and relieving asthma.For blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia asthma.Radix Rhodiolae can improve rapidly the binding ability of hemoglobin and oxygen, improves blood oxygen saturation, reduces the oxygen consumption of body, increases exercise tolerance, recovers Fatique after Sports.Radix Rhodiolae contains scopolamine, kaempferol, tannin; can improve the nonspecific resistance of human body to destructive stimulus, strengthen the adaptability of human body, improve the adaptive faculty of body to anoxia; suppress the generation of the radiation-induced heart and liver lipid peroxide, lipid and cell membrane are played a protective role.Radix Rhodiolae can significantly improve the activity of body superoxide dismutase, removes free radical, suppresses cylinder super-oxidation lipid and generates.
Preparation technology of the present invention, undertaken by following operation:
A) selected raw medicinal material Folium Nelumbinis, Flos Chrysanthemi Indici, Radix Rhodiolae, proportioning, put into respectively the drying machine dried according to the above ratio, and mix homogeneously obtains raw medicinal material;
B) selected raw medicinal material is put into respectively to rotary medicine cutter and be ground into fine powder, cross 300 mesh sieve holes, obtain the medical material fine powder;
C) Folium Nelumbinis fine powder input air flow formula super micron mill micronizing is distributed in to the Folium Nelumbinis ultramicro powder of 50~70 microns more than 99% to particle diameter, Radix Rhodiolae fine powder input air flow formula super micron mill micronizing is distributed in to the Radix Rhodiolae ultramicro powder of 0~20 micron more than 99% to particle diameter, Flos Chrysanthemi Indici extracts to obtain the Flos Chrysanthemi Indici extract powder through supercritical fluid extraction, its quality and crude drug fine powder mass ratio are 1:10, extracting pressure 10MPa, 37~39 ℃ of extraction temperature;
D) by Folium Nelumbinis ultramicro powder, Radix Rhodiolae ultramicro powder, Flos Chrysanthemi Indici extract powder according to 30~60 parts, Folium Nelumbinis, 10~12 parts of Flos Chrysanthemi Indicis, the weight ratio that Radix Rhodiolae is 10~12 parts is mixed, and its mixed-powder is the instant particles as Chinese medicine that the present invention treats metabolism syndrome and habitual constipation.
Study on Supermicro-pulverization of Traditional Chinese Drugs can improve the sporoderm-broken rate of crude drug cell, and cell intracellular effective ingredient after breaking cellular wall fully comes out, rate of release and the burst size of medicine can significantly improve.By micronizing, process, the ultramicro powder specific surface area is doubled and redoubled, and the surface charge of medicine, viscous force are changed, and makes it that good dissolubility, dispersibility, adsorptivity, chemical reactivity be arranged.Study on Supermicro-pulverization of Traditional Chinese Drugs had both guaranteed the mouthfeel that instant particles as Chinese medicine is good, guaranteed that again effective ingredient is not destroyed, and more was conducive to the absorption of human body.
Compared with prior art, the beneficial effect that the instant particles as Chinese medicine for the treatment of metabolism syndrome of the present invention and habitual constipation has is: the instant particles as Chinese medicine for the treatment of metabolism syndrome of the present invention and habitual constipation by change turbid heat clearing away, the removing toxic substances promote blood circulation, the intestinal stasis relieving relieving constipation, to reach YIN and YANG balance regulating, balance internal organs, dredging blood vessel, improve metabolism state, regulate blood fat, reverse atherosclerotic function, make all diseases from disappearing, lose weight, rate and blood-lipid decreased, defecation is normal.The present invention is instant particles as Chinese medicine, and formula is simple, dissolves rapidly, and normal-temperature water is solubilized, and only need take 2 every day, and taking convenience is without any side effects.Treated effect of the present invention and cure rate are higher, it takes and gets final product produce effects 1 course for the treatment of (30 days), blood fat reduces, defecation is normal, take 4 the course for the treatment of state of an illness can reach body weight and obviously alleviate, blood fat is normal, and atheromatous plaque dwindles and stablizes, and treated effect reaches 94%, cure rate reaches 88%, stable curative effect and difficult recurrence.
The specific embodiment
Embodiment 1~5
The proportioning component of the instant particles as Chinese medicine for the treatment of metabolism syndrome of the present invention and habitual constipation is as shown in table 1, and wherein embodiment 3 is most preferred embodiment.
The instant particles as Chinese medicine (in weight portion) of table 1 embodiment 1~5 treatment metabolism syndrome and habitual constipation
Figure GDA0000393029930000031
Concrete preparation technology is as follows:
A) selected raw medicinal material Folium Nelumbinis, Flos Chrysanthemi Indici, Radix Rhodiolae, proportioning, put into respectively the drying machine dried according to the above ratio, and mix homogeneously obtains raw medicinal material;
B) selected raw medicinal material is put into respectively to rotary medicine cutter and be ground into fine powder, cross 300 mesh sieve holes, obtain the medical material fine powder;
C) Folium Nelumbinis fine powder input air flow formula super micron mill micronizing is distributed in to the Folium Nelumbinis ultramicro powder of 50~70 microns more than 99% to particle diameter, Radix Rhodiolae fine powder input air flow formula super micron mill micronizing is distributed in to the Radix Rhodiolae ultramicro powder of 0~20 micron more than 99% to particle diameter, Flos Chrysanthemi Indici extracts to obtain the Flos Chrysanthemi Indici extract powder through supercritical fluid extraction, its quality and crude drug fine powder mass ratio are 1:10, extracting pressure 10MPa, 37~39 ℃ of extraction temperature;
D) by Folium Nelumbinis ultramicro powder, Radix Rhodiolae ultramicro powder, Flos Chrysanthemi Indici extract powder according to 30~60 parts, Folium Nelumbinis, 10~12 parts of Flos Chrysanthemi Indicis, the weight ratio that Radix Rhodiolae is 10~12 parts is mixed, and its mixed-powder is the instant particles as Chinese medicine that the present invention treats metabolism syndrome and habitual constipation.
Clinical practice of the present invention is summarized as follows:
The instant particles as Chinese medicine of this treatment metabolism syndrome and habitual constipation, ante cibum, warm water was taken after mixing it with water, and within 1 day, took 2 times, once took 15 grams, and taking continuously 30 days is 1 course for the treatment of.
Carry out clinical observation by the 25248 routine patients to taking Tonghua of the present invention ball, result is as follows:
Total case load 21176 examples, male patient's 13172 examples wherein, female patient accounts for 8004.Minimal ages 18 years old, at maximum 75 years old age, the patient that 45 years old or following patient account for 64.9%, 46~60 years old accounts for and accounts for 11.6% in 23.5%, 60 years old~75 years old.
The Simple Obesity Patient cardinal symptom: bad figure, handicapped, To Be Protected from Heat, causes heatstroke and heat collapse, the poor easy wound of endurance.
Habitual constipation patient cardinal symptom: defecation is less than 3 times weekly, and defecation is often felt difficulty, and complexion dusk is dim, too fat to move, presents abnormal ill face.
Metabolic Syndrome Patients cardinal symptom: abdominal obesity or overweight, atherogenicity, dyslipidemia [high triglyceride (TG) mass formed by blood stasis and HDL-C (HDL-C) are low], hypertension, insulin resistant and/or impaired glucose tolerance, short inflammatory conditions (C reactive protein CRP) increase and short thrombosis state (Fibrinogen increases and plasminogen mortifier-1, PAI-1) increases.
The hyperlipemia cardinal symptom: the intra-arterial face has the lipid striped, forms atherosclerotic plaque, angiostenosis, organ ischemia, and hypomnesis, dizziness, headache, cholesterolemia, triglyceride increase, and high density lipoprotein lowers, and the lipoprotein electrophoresis figure is abnormal.
Curative effect judging standard: the improvement situation according to above-mentioned symptom is divided into recovery from illness, produce effects and invalid by curative effect, take in 4 courses for the treatment of, whole disappearances of above-mentioned symptom or alleviation are recovery from illness, and part disappears or alleviation is produce effects, all the other are invalid, and total effective rate is obvious effective rate and cure rate sum.Oral instant particles as Chinese medicine warm water ante cibum of the present invention of patient is taken after mixing it with water, and every day 2 times, once takes 15 grams, and taking continuously 30 days is 1 course for the treatment of, takes continuously instant particles as Chinese medicine of the present invention and adds up after 4 courses for the treatment of, and statistical result is as shown in table 1:
Table 1 is taken the case statistics of the instant particles as Chinese medicine for the treatment of metabolism syndrome of the present invention and habitual constipation
Figure GDA0000393029930000041
As shown in table 1, total effective 21176 examples, 18589 examples of fully recovering, produce effects 1394 examples, take in 4 courses for the treatment of effective percentage 94%, cure rate 88%.
Model case
Liu, the man, 65 years old, on November 9th, 2009 owed to examine more than flexible half a year because of the right side limb activity.Patient's right side limb activity that broke out before half a year is unfavorable, is difficult to walking, through hospitalization, takes a turn for the better and leaves hospital, and leaves over the right side limb activity unfavorable, the numb limbs and tense tendons discomfort, and speech is stuttering puckery, without stupor, vomiting and nausea, diplopia etc.Receive sleep can, constipation, urine is adjusted.Dimly red tongue, tongue is white, stringy and hesitant pulse.Previously hypertension history there are more than 10 years, hyperlipemia more than 7 years.Have a medical check-up: Bp:165/105mmHg, right side upper and lower extremities muscular strength 4+ level, muscular tension is low.Auxiliary examination: left side basal ganglia region lacunar infarction is shown in the inspection of cranium brain magnetic resonance.Serum low-density LP cholesterol: 4.57mmol/l, cholesterol 6.39mmol/l, triglyceride: 2.46mmol/l.Tentative diagnosis: tcm diagnosis: apoplexy (wind-phlegm stasis blocking), Western medicine diagnose: 1. cerebral infarction sequela 2. hyperlipemias.Give antiplatelet aggregation, stabilize plaque, the treatments such as neuroprotective, and give the clear granule of arteries and veins and take after mixing it with water, each 15g, every day 2 times, after 24 days, patient's state of an illness obviously alleviates and leaves hospital, the right side limb activity is front strong flexibly, the speech normal, the dizzy improvement, free movement of the bowels, the rear conventional Aspirin enteric coatel tablets of leaving hospital, the simvastatin sheet is oral, the clear granule of arteries and veins is taken after mixing it with water, further consultation after February, upper disease obviously alleviates, the right side limbs are substantially without numb unfavorable sensation, dizziness alleviates, check: low-density lipoprotein cholesterol: 2.66mmol/l, cholesterol: 4.38mmol/l, triglyceride: 1.53mmol/l, carotid ultrasonography Doppler shows, the Atherosclerosis of Common Carotid Artery speckle obviously dwindles, and be the stability speckle.
Zhang, the man, 42 years old, because of body fat examining on May 10th, 2010 in more than 5 years gradually.This patient has a liking for the food delicious food usually, heavy, the time have headache uncomfortable, without the symptom and sign such as dizzy, uncomfortable in chest, previously without family's obesity history, without family's hypertension history.Have a medical check-up: height 172cm, body weight 98kg, 130 centimetres of abdominal circumferences, blood pressure 165/100mmHg, patient's body is the uniformity obesity, often have vertigo and tinnitus concurrently, limbs are heavy stagnant unfavorable, cough and tell the sticky thin foam expectorant of a large amount of white, and expectorant goes out spirit and QI cleaning, xerostomia wish drink, pale tongue is dark, white and greasy fur, pulse condition is heavy sliding.Auxiliary examination: endocrine, hepatic and renal function, cardio-pulmonary function etc. are all normal.Tentative diagnosis: tcm diagnosis: fat (containing in phlegm-damp), Western medicine diagnose: Simple Obesity.Give the clear granule of arteries and veins and take after mixing it with water, each 15g, every day 2 times, take 3 months continuously.Further consultation on August 16 in 2010, shape fertilizer subtracts, and abdominal circumference is little, dizzy alleviating, expectoration reduces, and the matter thickness, without malaise symptoms such as weak, asthenia, Mental fatigue.The tongue arteries and veins is as front.Have a medical check-up: body weight is kept to 82kg, and blood pressure is reduced to 135/80mmHg, and continue to take the clear granule of arteries and veins and take after mixing it with water, 1 dose of day, take February continuously, lose weight as 73kg, 90 centimetres of abdominal circumferences, blood pressure is normal.
Summer, the man, 50 years old, because prolonged constipation is examined in more than 10 years, previously life style was irregular, and constipation with dry stool is not all right, the abdominal distention and pain tenderness, long-term taking charthartic, distention and pain in the lower abdomen after an action of the bowels, sleep disorder, xerostomia halitosis, flushing vexed, oliguria with reddish urine, red tongue, thick and greasy fur, stringy and rolling pulse and the right side is larger.Tentative diagnosis: tcm diagnosis: constipation (the intestinal internal organs is scorching), Western medicine diagnose: constipation.Give the clear granule of arteries and veins and take after mixing it with water, each 15g, every day 2 times, continuous 10 doses, stool is profit gradually, and the abdominal part distending pain reduces by half.Continue and take 6 doses, the abdominal part distending pain disappears.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (1)

1. an instant particles as Chinese medicine for the treatment of metabolism syndrome and habitual constipation, it is characterized in that: the raw material of this effective ingredient is comprised of Folium Nelumbinis, Flos Chrysanthemi Indici and Radix Rhodiolae, and its weight proportion is 50 parts, Folium Nelumbinis, 10 parts of Flos Chrysanthemi Indicis, 12 parts of Radix Rhodiolaes.
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