CN102512178B - Blood oxygen measurer and method - Google Patents
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- CN102512178B CN102512178B CN201110437409.6A CN201110437409A CN102512178B CN 102512178 B CN102512178 B CN 102512178B CN 201110437409 A CN201110437409 A CN 201110437409A CN 102512178 B CN102512178 B CN 102512178B
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 90
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 90
- 239000001301 oxygen Substances 0.000 title claims abstract description 90
- 239000008280 blood Substances 0.000 title claims abstract description 82
- 210000004369 blood Anatomy 0.000 title claims abstract description 82
- 238000000034 method Methods 0.000 title abstract description 18
- 238000006243 chemical reaction Methods 0.000 claims abstract description 40
- 238000001914 filtration Methods 0.000 claims abstract description 40
- 238000012545 processing Methods 0.000 claims abstract description 22
- 238000004458 analytical method Methods 0.000 claims abstract description 18
- 230000003321 amplification Effects 0.000 claims abstract description 17
- 238000003199 nucleic acid amplification method Methods 0.000 claims abstract description 17
- 238000000605 extraction Methods 0.000 claims abstract description 12
- 238000001441 oximetry spectrum Methods 0.000 claims description 24
- 238000001514 detection method Methods 0.000 claims description 10
- 208000032843 Hemorrhage Diseases 0.000 claims description 7
- 230000007613 environmental effect Effects 0.000 claims description 7
- 230000005540 biological transmission Effects 0.000 claims description 6
- 230000002452 interceptive effect Effects 0.000 claims description 5
- 238000000354 decomposition reaction Methods 0.000 description 9
- 238000002496 oximetry Methods 0.000 description 7
- 230000008030 elimination Effects 0.000 description 4
- 238000003379 elimination reaction Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 3
- 230000008081 blood perfusion Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000010183 spectrum analysis Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention relates to the technical field of medical treatment products, in particular to a blood oxygen measurer and a method. The blood oxygen measurer comprises a light current signal acquisition unit, a signal conversion unit, an environment light signal filtering unit, a voltage signal amplification unit, an analog-to-digital conversion unit, a waveform signal extraction unit, a noise analysis unit, a waveform processing unit and a blood oxygen data calculating unit which are successively connected according to a signal flow direction, and the environment light signal filtering unit is connected with the signal conversion unit and used for filtering interference of environment light signals. The blood oxygen measurer is provided with the environment light signal filtering unit, when blood oxygen is measured, saturation of measured signals due to interference of environment light is avoided, so that the blood oxygen can be measured in various environments, the service range of the blood oxygen measurer is greatly expanded, and popularization is quite high.
Description
Technical field
the present invention relates to medical product technical field, be specifically related to a kind of blood oxygen measuring device and method.
Background technology
in pulse formula noinvasive oxygen saturation measurement technology, general be all by HONGGUANG and infrared light after the transillumination of tissue or reflected light are modulated by pulse wave, utilizing blood oxygen receiving sensor is that photodiode is converted to current signal by transillumination or reflected light, via the corresponding analog circuit of rear class, amplify conditioning, the blood oxygen signal that uses analog-digital converter collection to be beaten and modulated by pulse, send into single-chip microcomputer and carry out related operation, by corresponding algorithm, complete the isoparametric calculating of blood oxygen saturation, pulse frequency and pulse wave.
because this technology is the technology of utilizing HONGGUANG and infrared light and transillumination or reflected light thereof to detect, and detected blood oxygen signal is a small-signal, so be easy to be subject to the interference of external environment light, and surround lighting is a relatively strong signal, after making to be disturbed, when Oximetry, be easy to occur signal saturated phenomenon, thereby cannot carry out the measurement of blood oxygen saturation and pulse frequency, while particularly using in transhipment outside institute, problem can be more outstanding.
Summary of the invention
for overcoming above-mentioned defect, object of the present invention is a kind of blood oxygen measuring device and method.
the object of the invention is to be achieved through the following technical solutions:
a kind of blood oxygen measuring device of the present invention, mainly comprises:
photo-signal collecting unit, described photo-signal collecting unit is for gathering the photo-signal that measured is contained pulse signal;
signal conversion unit, described signal conversion unit is connected with photo-signal collecting unit, for the photo-signal collecting is converted to corresponding voltage signal;
ambient light signal filtering unit, described ambient light signal filtering unit is connected with described signal conversion unit, for the ambient light interference signal of filtering voltage signal;
voltage signal amplifying unit, described voltage signal amplifying unit is connected with ambient light signal filtering unit, for the voltage signal to after filtering environmental light interfering signal, amplifies;
aD conversion unit, described AD conversion unit is connected with described voltage signal amplifying unit, for the voltage signal to after amplifying, carries out analog digital conversion, obtains blood oxygen pulse data;
waveshape signal extraction unit, described waveshape signal extraction unit is connected with described AD conversion unit, for extracting hemorrhage oxygen pulse ripple signal from blood oxygen pulse data, and by low-pass filtering, obtain the DC component waveshape signal of blood oxygen pulse ripple, by bandpass filtering, obtain the AC compounent waveshape signal of blood oxygen pulse ripple simultaneously;
noise analysis unit, described noise analysis unit is connected with described waveshape signal extraction unit, for described AC compounent waveshape signal is carried out to noise analysis, thereby obtains the noise minutia of AC compounent waveshape signal;
waveform processing unit, described waveform processing unit is connected with described noise analysis unit, for dynamically adjust the noise threshold of waveform processing according to noise minutia, and according to noise threshold, AC compounent waveshape signal is eliminated to noise;
oximetry data computing unit, described oximetry data computing unit is connected with described waveform processing unit, for the AC compounent waveshape signal to after DC component waveshape signal and elimination noise, calculates Oximetry data.
a kind of blood oxygen measuring method of the present invention, mainly comprises:
obtain the photo-signal that contains pulse signal, and this photo-signal is converted to corresponding voltage signal;
by adjusting the interference of voltage signal filtering environmental optical signal;
voltage signal after adjusting is amplified, and carry out analog digital conversion, obtain blood oxygen pulse data;
from blood oxygen pulse data, extract hemorrhage oxygen pulse ripple signal, and by low-pass filtering, obtain the DC component waveshape signal of blood oxygen pulse ripple, by bandpass filtering, obtain the AC compounent waveshape signal of blood oxygen pulse ripple simultaneously;
described AC compounent waveshape signal is carried out to noise analysis, thereby obtain the noise minutia of AC compounent waveshape signal;
according to noise minutia, dynamically adjust the noise threshold of waveform processing, and according to noise threshold, AC compounent waveshape signal is eliminated to noise;
according to the AC compounent waveshape signal after DC component waveshape signal and waveform processing, calculate Oximetry data.
in the present invention, in a kind of device of Oximetry, be provided with ambient light signal filtering unit, make when carrying out Oximetry, can not cause because of the interference of surround lighting the saturated of measuring-signal, Oximetry can be carried out under various environment, expand greatly the scope of application of blood oxygen measuring device, there is high generalization.
Accompanying drawing explanation
for ease of explanation, the present invention is described in detail by following preferred embodiment and accompanying drawing.
fig. 1 is the structure principle chart of an embodiment of a kind of blood oxygen measuring device of the present invention;
fig. 2 is the structure principle chart of a kind of another embodiment of blood oxygen measuring device of the present invention;
fig. 3 is the circuit theory diagrams of an embodiment of a kind of blood oxygen measuring device of the present invention;
fig. 4 is the circuit theory diagrams of a kind of another embodiment of blood oxygen measuring device of the present invention;
fig. 5 is the flow chart of an embodiment of a kind of blood oxygen measuring method of the present invention;
fig. 6 is the flow chart of a kind of another embodiment of blood oxygen measuring method of the present invention.
The specific embodiment
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
refer to Fig. 1 to Fig. 4, the device of a kind of Oximetry of the present invention, mainly comprises:
photo-signal collecting unit 101, described photo-signal collecting unit 101 is for gathering the photo-signal that contains measured's pulse signal;
ambient light signal filtering unit 103, described ambient light signal filtering unit 103 is connected with described signal conversion unit 102, for filtering environmental light interfering signal; Described ambient light signal filtering unit 103 comprises the I/O mouth control level of resistance, electric capacity, operational amplifier, field effect transistor and single-chip microcomputer;
voltage signal amplifying unit 104, described voltage signal amplifying unit 104 is connected with ambient light signal filtering unit 103, for the voltage signal to after filtering environmental light interfering signal, amplifies;
waveshape signal extraction unit 106, described waveshape signal extraction unit 106 is connected with described AD conversion unit 105, for extracting hemorrhage oxygen pulse ripple signal from blood oxygen pulse data, and obtain the DC component waveshape signal of blood oxygen pulse ripple and store by low-pass filtering, by bandpass filtering, obtain the AC compounent waveshape signal of blood oxygen pulse ripple simultaneously;
oximetry data computing unit 109, described oximetry data computing unit 109 is connected with described waveform processing unit 108, for the AC compounent waveshape signal to after DC component waveshape signal and waveform processing, calculates Oximetry data.
further, described ambient light signal filtering unit 103 comprises:
range of signal expansion module 110, described range of signal expansion module 110 is connected with signal conversion unit 102, for increasing the dynamic detection range of voltage signal;
voltage baseline adjustment module 111, described voltage regulator module 111 is connected with range of signal expansion module 110, for the baseline voltage value to this voltage signal, adjusts, and the baseline voltage value after adjusting is fixed on default magnitude of voltage; Its detailed process is the adjustment of twice baseline voltage value, and being adjusted into of baseline voltage value, lowers baseline voltage value or raise for the first time, and within the baseline voltage value after making to lower is in dynamic detection range; After obtaining voltage signal, baseline voltage value is adjusted on default magnitude of voltage, thereby allows voltage signal Integral lifting in the situation that amplitude is constant.Preferably, will in baseline voltage value, be adjusted to 0V.
further, described blood oxygen measuring device also comprises: signal amplitude judging unit 112, amplifies compensation multiple computing unit 113, data transmission unit 114;
described signal amplitude judging unit 112 is connected with AD conversion unit 105, and for judging whether the blood oxygen pulse data after analog digital conversion reaches default threshold value, when not reaching default threshold value, drive amplification compensation multiple computing unit 113; When reaching default threshold value, drive waveforms signal extraction unit 106;
described amplification compensation multiple computing unit 113 is connected with voltage signal amplifying unit 104 with signal amplitude judging unit 112, for when blood oxygen pulse data does not reach default threshold value, according to default threshold value, the amplification compensation multiple of voltage signal is calculated, and this amplification compensation multiple is sent to voltage signal amplifying unit, to realize, the voltage signal after adjusting is carried out to amplification again;
described data transmission unit 114 is connected with oximetry data computing unit 109, for Oximetry data are sent to control terminal, control terminal follow-up to Oximetry data show, the work such as storage, printing and warning.
with an embodiment, introduce in detail the method for a kind of Oximetry of the present invention below, please refer to Fig. 5, idiographic flow is:
201. obtain photo-signal
utilize blood oxygen receiving sensor to obtain on detected body by the photo-signal that contains pulse signal of transmission or reflection gained;
202. photo-signals are converted to voltage signal
utilize current-voltage conversion circuit, this photo-signal is converted to corresponding voltage signal;
203. filtering environmental light disturb
by adjusting the ambient light interference signal in voltage signal filtering voltage signal;
204. voltage signals amplify
voltage signal after filtering environmental light interfering signal is amplified;
205. voltage signal analog digital conversion
carry out analog digital conversion, obtain blood oxygen pulse data;
206. extract pulse wave signal
from blood oxygen pulse data, extract hemorrhage oxygen pulse ripple signal, and by low-pass filtering, obtain the DC component waveshape signal of blood oxygen pulse ripple, by bandpass filtering, obtain the AC compounent waveshape signal of blood oxygen pulse ripple simultaneously;
in the AC compounent waveshape signal of described blood oxygen pulse ripple signal, the AC compounent waveshape signal that comprises two-way; One tunnel be with HONGGUANG by the beat AC compounent waveshape signal of the corresponding blood oxygen pulse ripple of reflect or reflect of pulse, another road is infrared light by the beat AC compounent waveshape signal of the corresponding blood oxygen pulse ripple of reflect or reflect of pulse;
207. noise analysis
aC compounent waveshape signal to described blood oxygen pulse ripple carries out noise analysis, thereby obtains the noise minutia of blood oxygen pulse ripple AC compounent waveshape signal;
208. waveform processing
according to noise minutia, dynamically adjust noise frequency threshold value and the amplitude threshold of waveform processing, and according to noise threshold, the AC compounent waveshape signal of blood oxygen pulse ripple is eliminated to noise to realize smooth waveform;
209. obtain Oximetry data
according to the AC compounent waveshape signal after DC component waveshape signal and elimination noise, by calculating Oximetry data.
wherein, described Oximetry data comprise: blood oxygen saturation data, pulse frequency data, plethysmography wave datum.
in order to understand the present invention, with another embodiment, the present invention is described in detail below, please refer to Fig. 6, be specially:
301. obtain photo-signal
utilize blood oxygen receiving sensor to obtain on detected body by the photo-signal that contains pulse signal of transmission or reflection gained;
302. photo-signals are converted to voltage signal
utilize current-voltage conversion circuit, this photo-signal is converted to corresponding voltage signal;
303. increase area detection signal
by bias voltage regulator circuit being set to adjust the voltage of baseline, thereby increase the detection range of blood oxygen signal; In measuring process, because be often superimposed with ambient light signal in received voltage signal, and cause voltage signal to exceed detection range, cannot carry out the measurement of oximetry data; And increased in the present invention the detection range of voltage signal, to guarantee that the voltage signal that is superimposed with ambient light signal is also within detection range;
304. pairs of voltage signals are adjusted
baseline voltage value to this voltage signal is adjusted, and the baseline voltage value after adjusting is fixed on default magnitude of voltage; Its detailed process is the adjustment of twice baseline voltage value, and being adjusted into of baseline voltage value, lowers baseline voltage value for the first time, and within the baseline voltage value after making to lower is in dynamic detection range; After obtaining voltage signal, will in baseline voltage value, be adjusted on default magnitude of voltage, thereby allow voltage signal Integral lifting in the situation that amplitude is constant.Preferably, will in baseline voltage value, be adjusted to 0V.
voltage signal amplifies
with the amplification compensation multiple of presetting, the voltage signal after adjusting is amplified;
306. voltage signal analog digital conversion
utilize resolution for high-resolution analog-digital converter more than sixteen bit carries out analog digital conversion, obtain blood oxygen pulse data;
307. judge whether pulse wave data reach threshold value
judge whether the blood oxygen pulse data after analog digital conversion reaches default threshold value, when not reaching default threshold value, enter the amplification compensation multiple of voltage signal is calculated; When reaching default threshold value, start to extract hemorrhage oxygen pulse ripple signal from blood oxygen pulse data;
308. calculate and revise the amplification compensation multiple of voltage signal
when not reaching default threshold value, according to default threshold value, the amplification compensation multiple of voltage signal is calculated, default amplification compensation multiple is modified, then according to amended amplification compensation multiple, enter voltage signal is amplified;
309. extract pulse wave signal
from blood oxygen pulse data, extract hemorrhage oxygen pulse ripple signal, and by low-pass filtering, obtain the DC component waveshape signal of blood oxygen pulse ripple, by bandpass filtering, obtain the AC compounent waveshape signal of blood oxygen pulse ripple simultaneously;
in the AC compounent waveshape signal of described blood oxygen pulse ripple signal, the AC compounent waveshape signal that comprises two-way; One tunnel be with HONGGUANG by the beat AC compounent waveshape signal of the corresponding blood oxygen pulse ripple of reflect or reflect of pulse, another road is infrared light by the beat AC compounent waveshape signal of the corresponding blood oxygen pulse ripple of reflect or reflect of pulse;
310. noise analysis
aC compounent waveshape signal to described blood oxygen pulse ripple carries out noise analysis, thereby obtains the noise details of blood oxygen pulse ripple AC compounent waveshape signal;
wherein, the noise minutia of obtaining blood oxygen pulse ripple AC compounent waveshape signal comprises:
the AC compounent waveshape signal of blood oxygen pulse ripple is converted to frequency-domain waveform from time domain waveform, and obtains noise details by spectrum analysis; When measured's blood perfusion is faint, through being conventionally superimposed with the random noise of higher-frequency on the blood oxygen pulse ripple AC compounent waveform of bandpass filtering, relatively be evenly distributed in the higher frequency range of frequency spectrum, and energy is less than signal energy, by spectrum analysis, can know frequency range and the energy range of noise, the periodic regime of known noise and amplitude range, obtain noise details; And the resolution of analog-digital converter is higher, more can retain the characteristic information of small size high-frequency noise, the identification accuracy of noise is higher.
or, in the time domain waveform of the AC compounent waveshape signal of blood oxygen pulse ripple, carry out noise peak detection, detect the peak value feature of noise, be converted to periodic regime and the amplitude range of noise, obtain noise details.
waveform processing
according to noise details, dynamically adjust noise frequency threshold value and the amplitude threshold of waveform processing, and according to noise threshold, the AC compounent waveshape signal of blood oxygen pulse ripple is eliminated to noise to realize smooth waveform;
wherein, waveform processing can have two kinds of implementation methods, a kind of implementation method is wavelet threshold denoising, according to the frequecy characteristic of the noise in noise minutia, judge whether dynamically to adjust the yardstick of the wavelet decomposition of AC compounent waveshape signal, if desired, carry out corresponding dynamically adjustment, and be recorded as the yardstick of real-time wavelet decomposition; If do not need, the yardstick of existing wavelet decomposition is recorded as to the yardstick of real-time wavelet decomposition, the yardstick of wavelet decomposition has determined that signal is by the degree of refinement of frequency decomposition, decomposition scale is less, signal and noise cannot significantly be divided and come, decomposition scale is larger, and the smoothness of signal waveform is larger
again according to the noise amplitude feature in the yardstick of real-time wavelet decomposition and noise minutia, dynamically adjust the threshold value of Wavelet Denoising Method, judge whether to reach the threshold value of Wavelet Denoising Method, reservation is higher than the AC compounent waveshape signal of the threshold value of Wavelet Denoising Method, give up the AC compounent waveshape signal lower than the threshold value of Wavelet Denoising Method, the AC compounent waveshape signal being eliminated after noise; Make the signal after reconstruct more accurately, more approach real pulse wave signal;
another kind of implementation method is according to noise minutia, dynamic cut-off frequency, the attenuation quotient of adjusting conventional filter, the AC compounent waveshape signal being eliminated after noise, reach better elimination noise, the object of level and smooth pulse wave, thus obtain more accurately, more real pulse wave signal;
312. obtain Oximetry data
according to the AC compounent waveshape signal after DC component waveshape signal and elimination noise, by calculating Oximetry data;
313. send Oximetry data
oximetry data are sent to control terminal, so as control terminal to oximetry data show, the work such as storage, printing and warning.
the foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (2)
1.
a blood oxygen measuring device, is characterized in that, comprising:
photo-signal collecting unit, described photo-signal collecting unit is for gathering the photo-signal that measured is contained pulse signal;
signal conversion unit, described signal conversion unit is connected with photo-signal collecting unit, for the photo-signal collecting is converted to corresponding voltage signal;
ambient light signal filtering unit, described ambient light signal filtering unit is connected with described signal conversion unit, for the ambient light interference signal of filtering voltage signal; Described ambient light signal filtering unit comprises: range of signal expansion module, and described range of signal expansion module is connected with signal conversion unit, for increasing the dynamic detection range of voltage signal; Voltage baseline adjustment module, described voltage baseline adjustment module is connected with range of signal expansion module, for the baseline voltage value to this voltage signal, adjusts, and the baseline voltage value after adjusting is fixed on default magnitude of voltage;
voltage signal amplifying unit, described voltage signal amplifying unit is connected with ambient light signal filtering unit, for the voltage signal to after filtering environmental light interfering signal, amplifies;
aD conversion unit, described AD conversion unit is connected with described voltage signal amplifying unit, for the voltage signal to after amplifying, carries out analog digital conversion, obtains blood oxygen pulse data;
waveshape signal extraction unit, described waveshape signal extraction unit is connected with described AD conversion unit, for extracting hemorrhage oxygen pulse ripple signal from blood oxygen pulse data, and by low-pass filtering, obtain the DC component waveshape signal of blood oxygen pulse ripple, by bandpass filtering, obtain the AC compounent waveshape signal of blood oxygen pulse ripple simultaneously;
noise analysis unit, described noise analysis unit is connected with described waveshape signal extraction unit, for described AC compounent waveshape signal is carried out to noise analysis, thereby obtains the noise minutia of AC compounent waveshape signal;
waveform processing unit, described waveform processing unit is connected with described noise analysis unit, for dynamically adjust the noise threshold of waveform processing according to noise minutia, and according to noise threshold, AC compounent waveshape signal is eliminated to noise;
oximetry data computing unit, described oximetry data computing unit is connected with described waveform processing unit, for the AC compounent waveshape signal to after DC component waveshape signal and waveform processing, calculates Oximetry data.
2.
blood oxygen measuring device according to claim 1, is characterized in that, described blood oxygen measuring device also comprises: signal amplitude judging unit, amplifies compensation multiple computing unit, data transmission unit;
described signal amplitude judging unit is connected with AD conversion unit, and for judging whether the blood oxygen pulse data after analog digital conversion reaches default threshold value, when not reaching default threshold value, drive amplification compensates multiple computing unit; When reaching default threshold value, drive waveforms signal extraction unit;
described amplification compensation multiple computing unit is connected with voltage signal amplifying unit with signal amplitude judging unit, for when blood oxygen pulse data does not reach default threshold value, according to default threshold value, the amplification compensation multiple of voltage signal is calculated, and this amplification compensation multiple is sent to voltage signal amplifying unit, to realize, the voltage signal after adjusting is carried out to amplification again;
described data transmission unit is connected with oximetry data computing unit, for Oximetry data are sent to control terminal.
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