CN102500005B - Blood transfusion system for autologous blood recovery, filtration and purification - Google Patents
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Abstract
本发明公开了一种自体血液回收过滤净化输血系统，包括依次通过管道连接的吸引头、储血滤血罐、储血加压袋、血液超滤净化器和血袋。本发明的技术效果在于，通过结构简单、使用方便、成本低廉的整套系统，实现了有效回收出血并过滤净化，清除血液中有害的游离血红蛋白、炎性介质、细胞激活产物、微小组织碎屑及微聚体等杂质颗粒，并浓缩血液，杜绝了既往过滤式血液回收所引起的不良输血反应。同时该系统能有效保留血液中血浆成分，保留了血小板成分，避免了清洗式血液回收清洗去了血液中凝血因子及血小板所致的对凝血功能的影响。该系统避免了异体血输注而引起的传染病，缓解了血源的紧张性，减轻了病人的经济负担。
The invention discloses an autologous blood recovery, filtration and purification blood transfusion system, which comprises a suction head, a blood storage filter tank, a blood storage pressurized bag, a blood ultrafiltration purifier and a blood bag sequentially connected by pipelines. The technical effect of the present invention is that, through the complete system with simple structure, convenient use and low cost, the effective recovery of bleeding and filtration and purification are realized, and harmful free hemoglobin, inflammatory mediators, cell activation products, tiny tissue debris and Micropolymers and other impurity particles, and concentrate the blood, eliminating the adverse blood transfusion reaction caused by the previous filtration blood recovery. At the same time, the system can effectively retain the plasma components in the blood, retain the platelet components, and avoid the impact on the coagulation function caused by cleaning blood coagulation factors and platelets in the blood. This system avoids infectious diseases caused by allogeneic blood transfusion, relieves the tension of blood sources, and reduces the economic burden of patients.
Description
技术领域 technical field
本发明涉及一种自体血液回收过滤净化输血系统，特别涉及一种能有效滤除血液中有害细胞炎性因子，并保留血液中红细胞、血小板及血浆成分的自体血液回收过滤净化输血系统。The invention relates to an autologous blood recovery, filtration, and purification blood transfusion system, in particular to an autologous blood recovery, filtration, and purification blood transfusion system that can effectively filter out harmful inflammatory factors in blood and retain red blood cells, platelets and plasma components in the blood.
背景技术 Background technique
血液回收根据对收集血液的处理方式分为清洗式血液回收及过滤式血液回收。过滤式血液回收结构简单，操作方便。但是由于回收过程中存在一定程度的溶血、凝血-纤溶系统及炎性细胞的激活，且回收血液中含有不同浓度的游离血红蛋白炎性介质及细胞激活产物，同时还可能混有脂肪颗粒等微小组织碎屑及微聚体等杂质颗粒，回输回收血时，尤其在量大时可能导致肾功能损害、高钾血症、弥漫性血管内凝血等并发症或发热、低血压和上气道水肿等不良反应，因而限制了它的应用。而清洗式血液回收洗除了90％以上的血浆成分、血小板、细胞碎屑、游离Hb和活性物质(激活的凝血物质、血小板、补体等)，因而应用范围较广。但其操作较复杂，设备较昂贵，而且其只主要保留了红细胞成分，不能有效保留血浆及学小板，大量输注时可能影响凝血功能，需要另外补充血浆及血小板。故目前尚没有一种较完美的血液回收方式。Blood salvage can be divided into cleaning blood salvage and filter blood salvage according to the processing method of collected blood. The filter type blood recovery is simple in structure and easy to operate. However, due to a certain degree of hemolysis, coagulation-fibrinolysis system and activation of inflammatory cells in the recovery process, and the recovered blood contains different concentrations of free hemoglobin inflammatory mediators and cell activation products, and may also be mixed with tiny particles such as fat particles. Impurity particles such as tissue debris and microaggregates may lead to complications such as renal function damage, hyperkalemia, disseminated intravascular coagulation, or fever, hypotension and upper airway problems when reinfused into recovered blood, especially in large amounts. Adverse reactions such as edema limit its application. The cleaning blood recovery removes more than 90% of plasma components, platelets, cell debris, free Hb and active substances (activated coagulation substances, platelets, complement, etc.), so it has a wide range of applications. However, its operation is more complicated, the equipment is more expensive, and it only mainly retains red blood cell components, and cannot effectively retain plasma and platelets. Large-scale infusion may affect blood coagulation function, and additional plasma and platelets need to be supplemented. Therefore, there is still no perfect blood recovery method at present.
发明内容 Contents of the invention
为了解决现有清洗式血液回收副作用较大而导致应用面不广及过滤式血液回收成本较高的技术问题，本发明提供一种结构简单，使用方便，成本低廉，能清除回收血液中的游离血红蛋白、炎性介质、细胞激活产物、微小组织碎屑、微聚体等杂质颗粒。有效保留血液中血浆成分，保留了血小板成分，对病人凝血功能影响小的自体血液回收过滤净化输血系统。In order to solve the technical problems of the existing cleaning-type blood recovery with relatively large side effects and the high cost of filter-type blood recovery due to its limited application range, the present invention provides a simple structure, convenient use, low cost, and capable of removing free blood in recovered blood. Impurity particles such as hemoglobin, inflammatory mediators, cell activation products, tiny tissue debris, and microaggregates. Effectively retain the plasma components in the blood, retain the platelet components, and recover and filter the autologous blood that has little effect on the patient's blood coagulation function to purify the blood transfusion system.
为了实现上述技术目的，本发明的技术方案是，一种自体血液回收过滤净化输血系统，包括依次通过管道连接的吸引头、储血滤血罐、储血加压袋、血液超滤净化器和血袋，所述的储血滤血罐包括内罐和外罐，所述的内罐设置于外罐内部，内罐的侧壁为滤网，吸引头通过管道连接至内罐，外罐通过管道连接至储血加压袋，所述的储血加压袋包括储血内袋、加压外袋、简易空气加压装置和压力表，所述的储血内袋密封的设置于加压外袋内，所述的简易空气加压装置通过管道连接至加压外袋，所述的压力表连接至简易空气加压装置和加压外袋之间，储血内袋的输入端连接储血滤血罐的外罐，储血内袋的输出端连接血液超滤净化器。In order to achieve the above-mentioned technical purpose, the technical solution of the present invention is an autologous blood recovery, filtration, and purification blood transfusion system, which includes a suction head, a blood storage filter tank, a blood storage pressurized bag, a blood ultrafiltration purifier, and The blood bag, the blood storage and filtration tank includes an inner tank and an outer tank, the inner tank is arranged inside the outer tank, the side wall of the inner tank is a filter screen, the suction head is connected to the inner tank through a pipeline, and the outer tank passes through The pipeline is connected to the blood storage pressurized bag. The blood storage pressurized bag includes a blood storage inner bag, a pressurized outer bag, a simple air pressurization device and a pressure gauge. In the outer bag, the simple air pressurization device is connected to the pressurization outer bag through a pipeline, the pressure gauge is connected between the simple air pressurization device and the pressurization outer bag, and the input end of the blood storage inner bag is connected to the storage The outer tank of the hemofiltration blood tank and the output end of the blood storage inner bag are connected with a blood ultrafiltration purifier.
所述的一种自体血液回收过滤净化输血系统，所述的储血滤血罐的内罐上设有循环血液入口，所述的血液超滤净化器与血袋之间的连接管道上设有第一三通阀，所述的储血滤血罐和储血加压袋之间的连接管道上设有第二三通阀，所述的第一三通阀包括用于连接血液超滤净化器的净化器口、用于连接血袋的血袋口和用于连接循环血液入口或第二三通阀的第一循环口，所述的第二三通阀包括用于连接储血滤血罐的血罐口、用于连接储血加压袋的加压袋口和用于连接第一三通阀的第二循环口。The described autologous blood recovery, filtration and purification blood transfusion system, the inner tank of the blood storage and filtration tank is provided with a circulating blood inlet, and the connecting pipe between the blood ultrafiltration purifier and the blood bag is provided with The first three-way valve, the connecting pipeline between the blood storage filter tank and the blood storage pressurized bag is provided with a second three-way valve, and the first three-way valve includes a The purifier port of the device, the blood bag port for connecting the blood bag, and the first circulation port for connecting the circulating blood inlet or the second three-way valve, the second three-way valve includes a The blood tank port of the tank, the pressurized bag port for connecting the blood storage pressurized bag and the second circulation port for connecting the first three-way valve.
所述的一种自体血液回收过滤净化输血系统，还包括装有抗凝剂的抗凝药袋，所述的抗凝药袋通过管道连接至吸引头。The autologous blood recovery, filtration, and purification transfusion system also includes an anticoagulant bag filled with anticoagulant, and the anticoagulant bag is connected to the suction head through a pipeline.
所述的一种自体血液回收过滤净化输血系统，还包括微栓过滤器，所述的微栓过滤器设置于第一三通阀与血袋之间的连接管道上。The autologous blood recovery, filtration, purification and transfusion system further includes a microembolism filter, and the microemboli filter is arranged on the connecting pipeline between the first three-way valve and the blood bag.
所述的一种自体血液回收过滤净化输血系统，所述的储血滤血罐上设有负压吸引管。Said autologous blood recovery, filtration and purification blood transfusion system, said blood storage and filtration tank is provided with a negative pressure suction tube.
所述的一种自体血液回收过滤净化输血系统，所述的血液超滤净化器包括净化器本体和废液袋，所述的净化器本体的输入端连接储血加压袋，净化器本体的输出端连接第一三通阀，净化器本体的侧管连接废液袋。The autologous blood recycles, filters and purifies blood transfusion system, the blood ultrafiltration purifier includes a purifier body and a waste liquid bag, the input end of the purifier body is connected to a blood storage pressurized bag, and the purifier body The output end is connected to the first three-way valve, and the side pipe of the purifier body is connected to the waste liquid bag.
所述的一种自体血液回收过滤净化输血系统，所述的储血滤血罐的内罐侧壁为40um的滤网。Said autologous blood recovery, filtration and purification blood transfusion system, the inner side wall of said blood storage and filtration tank is a filter screen of 40um.
本发明的技术效果在于，通过结构简单、使用方便、成本低廉的整套系统，实现了有效回收出血并过滤净化，清除血液中有害的游离血红蛋白、炎性介质、细胞激活产物、微小组织碎屑及微聚体等杂质颗粒，并浓缩血液，杜绝了既往过滤式血液回收所引起的不良输血反应。同时该系统能有效保留血液中血浆成分，保留了血小板成分，避免了清洗式血液回收清洗去了血液中凝血因子及血小板所致的对凝血功能的影响。该系统避免了异体血输注而引起的传染病，缓解了血源的紧张性，减轻了病人的经济负担。The technical effect of the present invention is that, through the complete system with simple structure, convenient use and low cost, the effective recovery of bleeding and filtration and purification are realized, and harmful free hemoglobin, inflammatory mediators, cell activation products, tiny tissue debris and Micropolymers and other impurity particles, and concentrate the blood, eliminating the adverse blood transfusion reaction caused by the previous filtration blood recovery. At the same time, the system can effectively retain the plasma components in the blood, retain the platelet components, and avoid the impact on the coagulation function caused by cleaning blood coagulation factors and platelets in the blood. This system avoids infectious diseases caused by allogeneic blood transfusion, relieves the tension of blood sources, and reduces the economic burden of patients.
下面结合附图对本发明作进一步说明。The present invention will be further described below in conjunction with accompanying drawing.
附图说明 Description of drawings
图1为本发明的结构示意图；Fig. 1 is a structural representation of the present invention;
其中，1为吸引头，2为抗凝药袋，3为储血滤血罐，4为第二三通阀，5为储血加压袋，6为简易空气加压装置，7为压力表，8为血液超滤净化器，9为废液袋，10为第一三通阀，11为微栓过滤器，12为血袋，13为负压吸引管，14为循环血液入口，15为储血内袋，16为加压外袋。Among them, 1 is the suction head, 2 is the anticoagulant medicine bag, 3 is the blood storage filter tank, 4 is the second three-way valve, 5 is the blood storage pressure bag, 6 is the simple air pressurization device, and 7 is the pressure gauge , 8 is a blood ultrafiltration purifier, 9 is a waste liquid bag, 10 is a first three-way valve, 11 is a microembolus filter, 12 is a blood bag, 13 is a negative pressure suction tube, 14 is a circulating blood inlet, and 15 is a Blood storage inner bag, 16 is the pressurized outer bag.
具体实施方式 Detailed ways
参见图1，本发明包括依次通过管道连接的吸引头1、储血滤血罐3、储血加压袋5、血液超滤净化器8和血袋12。储血滤血罐3包括内罐和外罐，内罐设置于外罐内部，内罐的侧壁为40um的滤网，吸引头1通过管道连接至内罐，外罐通过管道连接至储血加压袋5，内罐可过滤血凝快组织碎屑等。回收一定量血(500-1000ml)后开放其第二三通阀4让初步过滤的血液进入储血加压袋5的储血内袋15，储血滤血罐3上设有负压吸引管13以便使血液流通顺畅。Referring to FIG. 1 , the present invention includes a suction head 1 , a blood storage filter tank 3 , a blood storage pressurized bag 5 , a blood ultrafiltration purifier 8 and a blood bag 12 connected sequentially through pipelines. The blood storage and filtration tank 3 includes an inner tank and an outer tank, the inner tank is arranged inside the outer tank, the side wall of the inner tank is a 40um filter screen, the suction head 1 is connected to the inner tank through a pipeline, and the outer tank is connected to the blood storage tank through a pipeline Pressurized bag 5, inner tank can filter hemagglutination fast tissue debris etc. Recover a certain amount of blood (500-1000ml) and open its second three-way valve 4 to allow the pre-filtered blood to enter the blood storage inner bag 15 of the blood storage pressurized bag 5, and the blood storage filter tank 3 is provided with a negative pressure suction tube 13 for smooth blood circulation.
储血加压袋5包括储血内袋15、加压外袋16、简易空气加压装置6和压力表7，储血内袋15密封的设置于加压外袋16内，简易空气加压装置6通过管道连接至加压外袋16，压力表7连接至简易空气加压装置6和加压外袋16之间，储血内袋15的输入端连接储血滤血罐3的外罐，储血内袋15的输出端连接血液超滤净化器8。充满后关闭第二三通阀4，并在外袋内注入空气。简易空气加压装置6使用常用的简易血压计的充气球即可。在注入气体管道上接有压力表7。简易空气加压装置6注入空气后使储血加压袋5内袋的血进入下方的血液超滤净化器8。设置简易空气加压装置6的原因是因为只有压力差才能使血液超滤净化器8发挥滤过作用，其控制压力为200-300mmHg，可使血液下行流量达50-150ml/分钟，1000ml回收血滤过时间只需10-20分钟。The blood storage pressurization bag 5 includes a blood storage inner bag 15, a pressurization outer bag 16, a simple air pressurization device 6 and a pressure gauge 7. The blood storage inner bag 15 is sealed and arranged in the pressurization outer bag 16, and the simple air pressurization The device 6 is connected to the pressurized outer bag 16 through a pipeline, the pressure gauge 7 is connected between the simple air pressurization device 6 and the pressurized outer bag 16, and the input end of the blood storage inner bag 15 is connected to the outer tank of the blood storage filter tank 3 , the output end of the blood storage inner bag 15 is connected to the blood ultrafiltration purifier 8 . Close the second three-way valve 4 after being full, and inject air in the outer bag. The simple air pressurizing device 6 can use the inflatable ball of a common simple sphygmomanometer. A pressure gauge 7 is connected to the injection gas pipeline. After the simple air pressurization device 6 injects air, the blood in the inner bag of the blood storage pressurization bag 5 enters the blood ultrafiltration purifier 8 below. The reason for installing the simple air pressurizing device 6 is because only the pressure difference can make the blood ultrafiltration purifier 8 play a filtering role, and its control pressure is 200-300mmHg, which can make the blood flow rate reach 50-150ml/min, and 1000ml of blood can be recovered. Filtration time only needs 10-20 minutes.
血液超滤净化器8包括净化器本体和废液袋9，净化器本体的输入端连接储血加压袋5，净化器本体的输出端连接第一三通阀10，净化器本体的侧管连接废液袋9。血液超滤净化器8的滤过膜为聚酰胺膜，其具有较好的生物相容性无毒。其可以模拟正常肾小球的滤过功能，及主要通过对流的方式来清除水分、电解质、中小分子物质，而蛋白等大分子量的物质不能通过。血液通过血液超滤净化器8后滤除了水分、电解质、中小分子物质及大量的炎性因子，而保留了血浆内的蛋白、凝血因子及有型血液细胞成分。The blood ultrafiltration purifier 8 includes a purifier body and a waste liquid bag 9, the input end of the purifier body is connected to the blood storage pressurized bag 5, the output end of the purifier body is connected to the first three-way valve 10, and the side pipe of the purifier body Connect waste bag 9. The filter membrane of the blood ultrafiltration purifier 8 is a polyamide membrane, which has good biocompatibility and is non-toxic. It can simulate the filtration function of normal glomeruli, and mainly remove water, electrolytes, and small and medium molecular substances through convection, while substances with large molecular weights such as proteins cannot pass through. After the blood passes through the blood ultrafiltration purifier 8, water, electrolytes, small and medium molecular substances and a large number of inflammatory factors are filtered out, while proteins, coagulation factors and shaped blood cell components in the plasma are retained.
在储血滤血罐3的内罐上设有循环血液入口14，血液超滤净化器8与血袋12之间的连接管道上设有第一三通阀10，储血滤血罐3和储血加压袋5之间的连接管道上设有第二三通阀4，第一三通阀10包括用于连接血液超滤净化器8的净化器口、用于连接血袋12的血袋12口和用于连接循环血液入口14或第二三通阀4的第一循环口，第二三通阀4包括用于连接储血滤血罐3的血罐口、用于连接储血加压袋5的加压袋口和用于连接第一三通阀10的第二循环口。通过血液超滤净化器8滤过后的血液可以从第一三通阀10门连接到储血滤血罐3或者储血加压袋5再次循环重复超滤净化，以达到最佳的过滤效果。The inner tank of the blood storage and filtration tank 3 is provided with a circulating blood inlet 14, and the connecting pipeline between the blood ultrafiltration purifier 8 and the blood bag 12 is provided with a first three-way valve 10, and the blood storage and filtration tank 3 and A second three-way valve 4 is provided on the connecting pipeline between the blood storage pressurized bags 5, and the first three-way valve 10 includes a purifier port for connecting the blood ultrafiltration purifier 8, a blood purifier for connecting the blood bag 12 Bag 12 mouth and the first circulation mouth that is used to connect circulating blood inlet 14 or second three-way valve 4, and second three-way valve 4 includes the blood tank mouth that is used to connect blood storage filter tank 3, is used to connect blood storage The pressurized bag opening of the pressurized bag 5 is used to connect the second circulation port of the first three-way valve 10 . The blood filtered by the blood ultrafiltration purifier 8 can be connected to the blood storage filter tank 3 or the blood storage pressurized bag 5 from the first three-way valve 10 to recirculate and repeat the ultrafiltration purification to achieve the best filtering effect.
装有抗凝剂的抗凝药袋2通过管道连接至吸引头1，回收血时同时在吸引头1内输注抗凝剂，本系统使用的抗凝剂是枸橼酸钠，其能有效防止回收的血液凝固，同时回输给病人时不需特殊拮抗，因其在体内很快就被肝脏代谢，而且必要时补充钙剂即可对抗其抗凝作用。The anticoagulant bag 2 filled with anticoagulant is connected to the suction head 1 through a pipeline, and the anticoagulant is infused in the suction head 1 at the same time when the blood is recovered. The anticoagulant used in this system is sodium citrate, which can effectively To prevent coagulation of recovered blood, at the same time, no special antagonism is required when it is reinfused to the patient, because it is quickly metabolized by the liver in the body, and calcium supplementation can counteract its anticoagulant effect if necessary.
血袋12回输病人时加用微栓过滤器11，微栓过滤器11设置于第一三通阀10与血袋12之间的连接管道上。When the blood bag 12 is transfused back to the patient, the microembolus filter 11 is added, and the microembolus filter 11 is arranged on the connecting pipeline between the first three-way valve 10 and the blood bag 12 .
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN205163774U (en) * | 2013-12-08 | 2016-04-20 | 杨海龙 | Suspension type feedback blood ware |
| CN105999445A (en) * | 2016-08-02 | 2016-10-12 | 宁波市妇女儿童医院 | Method for treating recycled blood in cesarean section |
| CN106110750B (en) * | 2016-08-15 | 2018-10-16 | 鲁绍荣 | A kind of efficient blood recovery system |
| US11628241B2 (en) | 2017-06-22 | 2023-04-18 | Nipro Corporation | Blood purification apparatus |
| BR112020013045A2 (en) * | 2017-12-28 | 2020-12-01 | I-Sep | system and method of treating hemorrhagic fluid for autotransfusion |
| CN108853619A (en) * | 2018-03-23 | 2018-11-23 | 山东大学齐鲁医院 | Autogenous vein device with choke preventing function |
| CN109793957B (en) * | 2019-03-27 | 2021-08-24 | 南京市儿童医院 | A Simple Autologous Blood Recycler |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3986956A (en) * | 1973-12-04 | 1976-10-19 | Tokyo Shibaura Electric Co., Ltd. | Artificial kidney device |
| US4559034A (en) * | 1981-04-16 | 1985-12-17 | Kawasumi Laboratories, Inc. | Line for use in body fluid treatment |
| CN202236538U (en) * | 2011-09-30 | 2012-05-30 | 中南大学 | Recovery, filtration, purification and transfusion system of autoblood |
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2011
- 2011-09-30 CN CN201110296345.2A patent/CN102500005B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3986956A (en) * | 1973-12-04 | 1976-10-19 | Tokyo Shibaura Electric Co., Ltd. | Artificial kidney device |
| US4559034A (en) * | 1981-04-16 | 1985-12-17 | Kawasumi Laboratories, Inc. | Line for use in body fluid treatment |
| CN202236538U (en) * | 2011-09-30 | 2012-05-30 | 中南大学 | Recovery, filtration, purification and transfusion system of autoblood |
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| CN102500005A (en) | 2012-06-20 |
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