CN106344985B - A kind of multifunctional recycled blood purification system - Google Patents
A kind of multifunctional recycled blood purification system Download PDFInfo
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- CN106344985B CN106344985B CN201610834013.8A CN201610834013A CN106344985B CN 106344985 B CN106344985 B CN 106344985B CN 201610834013 A CN201610834013 A CN 201610834013A CN 106344985 B CN106344985 B CN 106344985B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
- A61M1/3635—Constructional details
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
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Abstract
The present invention relates to a kind of multifunctional recycled blood purification systems.Including blood purification mechanism, dialyzate supplementary mechanism, toxin adsorbing mechanism；Specifically include two high flux hemodialysis devices, ultrafiltrate pump, kinetic pump, artery pot, venous chambers, bag filter, albumin container, carbon adsorption column, resin absorbing column and waste liquid pool.During work, it is water-insoluble in blood, be eliminated with the toxin cross tunica fibrosa of albumin combination through multiple absorption, in blood it is water-soluble in, small molecule toxins are eliminated through continuous blood purification, electrolyte balance is effectively realized by continuous blood purification, adsorbent is realized using the desorption of adsorbent（Such as activated carbon and resin）Regeneration and reuse.Adsorbent of the present invention consumption less, toxin remove type is more, electrolyte balance soon, go that oedema effect is good, treatment time is short, system cost is low, safety is good and can realize personalized treatment.
Description
Technical field
The invention belongs to the field of medical instrument technology, are related to a kind of for the novel of the diseases such as acute and chronic liver failure
Liver function supports system, i.e., a kind of regeneration and recycling that a variety of adsorbents can be achieved increases blood purification system Dusuqing
The type removed maintains cylinder electrolyte balance, eliminates human body oedema, improve the good biocompatibility of blood depuration efficiency, can have
Effect prevents medical albumin and adsorbent enter human body novel and multifunctional regeneration blood purification system design.
Background technology
Liver failure has become the critical illness for threatening the health of our people, and inducement mainly has immune injury, virus
Invasion, drug abuse and chronic alcoholism etc..Liver transfer operation is current treatment hepatic failure most effective way, but due to liver source is deficient,
Matching is difficult, the waiting donor time is very long and medical expense is expensive and limits its clinical practice, therefore there is an urgent need to liver function branch
Hold the development of system Medical Devices.Multifunctional recycled blood purification system（ALSS）It, can be temporarily as a kind of liver function replacement device
When assist lesion liver（Remove multiple harmful substances, execution part metabolic function）, until self liver function restore or into
Row liver transplant, so one of the effective ways as hepatic failure treatment.Multifunctional recycled blood purification system is typically based on blood
Starch the technologies such as displacement, haemodialysis, blood filtration, plasma dialysis filtering, blood perfusion, albumin dialysis, absorption removal blood
Middle toxin.Currently, multifunctional recycled blood purification system mainly has single cycle albumin dialysis system（SPAD）, Molecular Adsorption again
The circulatory system（MARS）And Prometheus（Prometheus）Deng.These systems can remove not soluble in water and protein knot
The toxin of conjunction, but all there are it is respective the problem of, such as：The elimination efficiency of MARS system toxin not only sorbent suspension dosage and type
Influence, while also limited by tunica fibrosa mass-transfer efficiency；The albumin loss of Prometheus systems human body itself is big；
SPAD systems need to cause treatment cost high with a large amount of human albumins.
The basic principle of liver system be by a device temporarily or completely substitute serious change hepatic portion or
Repertoire, mainly remove patient's body due to liver function lose and accumulate promote liver organization that can not regenerate, firmly
Change with the metabolin toxin of carcinogenesis.Currently, generally use dialysis removes water-soluble metabolin toxin, using absorption side
Formula removal is not soluble in water, metabolin toxin with albumin combination.But unreasonable design may lead to itself albumin
Loss, adsorbent particles enter human body, adsorbent utilization rate are low, itself albumin is polluted by external albumin etc., so as to cause
Not only liver system price is expensive, but also toxin elimination efficiency can be caused low and safety risks.
Invention content
The object of the present invention is to provide a kind of multifunctional recycled blood purification systems.
A kind of multifunctional recycled blood purification system includes blood purification mechanism, dialyzate supplementary mechanism, toxin adsorption machine
Structure 9；
The blood purification mechanism includes the first high flux hemodialysis device 71 and the second high flux hemodialysis device 72 of series connection；
First blood inlet 711 of the first high flux hemodialysis device 71 is sequentially connected in series the first artery pot 61, blood pump 11
With input check valve 211, the import of input check valve 211 is the import of blood purification mechanism；
The albumin solution of first high flux hemodialysis device 71 exports 713 the first ultrafiltrate pump 13, first by being sequentially connected in series
Drug abuse check valve 25 connects the import of toxin adsorbing mechanism 9, the white egg of the first high flux hemodialysis device 71 with the second artery pot 62
White solution inlet port 712 connects the first albumin solution interface by the second kinetic pump 14 of series connection；
The first blood outlet 714 of first high flux hemodialysis device 71 and the second blood inlet of the second high flux hemodialysis device 72
Third of connecting between 721 artery pot 63；
The dialyzate of the second high flux hemodialysis device 72 exports 722 the second ultrafiltrate pump 15 and second by being sequentially connected in series
Waste liquid check valve 210 is connected to waste liquid interface；The second blood outlet 723 of second high flux hemodialysis device 72 is sequentially connected in series vein
Pot 64, output one-way valve 212；
The entrance of wherein input check valve 211 is the input terminal of the system, and the outlet of output one-way valve 212 is the system
The output terminal of system；
It is single that the dialyzate supplementary mechanism includes the first kinetic pump 12, dialysis check valve 21, displacement check valve 22 and purification
To valve 23；Dialysis check valve 21 and displacement check valve 22 are connected in parallel on the import of the first kinetic pump 12, the import for check valve 21 of dialysing
Dialyzate bag 81 is connected, the inlet communication of displacement check valve 22 displacement liquid bag 82；The outlet for purifying check valve 23 is dialysis
The outlet of liquid supplementary mechanism, the outlet of dialyzate supplementary mechanism or connects the import of third artery pot 63 or connects venous chambers
64 import；
The toxin adsorbing mechanism 9 includes the second drug abuse check valve 26, carbon adsorption column 911 and the resin absorbing column of series connection
912, the carbon adsorption column 911 and resin absorbing column 912 of series connection are located on oscillating mechanism 5；The input end of wherein carbon adsorption column 911 is
The import of toxin adsorbing mechanism 9, the port of export of resin absorbing column 912 are the outlet of toxin adsorbing mechanism 9, form a kind of toxin and inhale
Attached pattern；
The entrance of toxin adsorbing mechanism 9 is equipped with the second artery pot 62, and the first import of the second artery pot 62 passes through removing toxic substances
Check valve 24 connects the outlet of the first kinetic pump 12, and the second inlet communication of the second artery pot 62 the first drug abuse check valve 25
Outlet；
The outlet of toxin adsorbing mechanism 9 connects the second albumin solution interface by third drug abuse check valve 29 or passes through
First waste liquid check valve 28 connects waste liquid pool 16；
During work, the first albumin solution interface and the second albumin solution interface are respectively communicated with the two of albumin container 10
A port；
The input check valve 211, blood pump 11, the first artery pot 61, the first high flux hemodialysis device 71, third artery pot
63rd, the second high flux hemodialysis device 72, venous chambers 64 and output one-way valve 212 form blood circulation mechanism；
The first high flux hemodialysis device 71, the first ultrafiltrate pump 13, the first drug abuse check valve 25 and the second artery pot 62, poison
Plain adsorbing mechanism 9, third drug abuse check valve 29, albumin solution container 10, the second kinetic pump 14 form albumin circulation mechanism；
The dialysis check valve 21, dialyzate bag 81, displacement check valve 22, displacement liquid bag 82, the first kinetic pump 12, removing toxic substances
Check valve 24, the second artery pot 62, toxin adsorbing mechanism 9, the first waste liquid check valve 28, waste liquid pool 16 form adsorbent and white egg
White regeneration sector；
The system realizes following operate：
During for removing septicemia element, blood circulation mechanism, blood purification mechanism, dialyzate supplementary mechanism, toxin are inhaled
Random structure 9 and the work of albumin circulation mechanism, adsorbent and albumin regeneration sector are stopped；The first of second artery pot 62
Import is closed, and the second import of the second artery pot 62 is connected；When removing with albumin combination toxoid, described first is high-throughput saturating
Second albumin solution interface of the first albumin solution interface and toxin adsorbing mechanism 9 outlet of parser 71 is respectively communicated in vain
Albumen container 10；When removing in blood not with albumin combination toxoid and extra moisture, dialyzate supplementary mechanism work
Make, the second blood entry port of the second high flux hemodialysis device connects the outlet of third artery pot 63, the second high flux hemodialysis
The dialyzate outlet waste liquid pool 16 of device 72；
When wherein, for blood circulation, blood of human body is defeated through output one-way valve 212 through inputting 211 input system of check valve
Human body is flowed back to after going out system；When supplementing dialyzate, dialysis liquid interface and displacement liquid interface connect dialyzate bag 81 and displacement respectively
Liquid bag 82, there are three types of connection mode, the import for individually connecting third artery pot 63 forms for the outlet of dialyzate supplementary mechanism
A kind of dialyzate supplement mode, the import for individually connecting venous chambers 64 form second of dialyzate supplement mode, can also be same
Shi Liantong the import of third artery pot 63 and the import of venous chambers 64 forms the third dialyzate supplement mode；Toxin adsorbs
When, the entrance and exit of the toxin adsorbing mechanism 9 is respectively turned on the outlet of the second artery pot 62 and albumin container 10
Bisalbumin solution interface；
When being regenerated for adsorbent and albumin, blood circulation mechanism, dialyzate supplementary mechanism, blood purification mechanism and white
Protein circulation mechanism is stopped, and toxin adsorbing mechanism 9 and adsorbent and albumin regeneration sector work；The second artery pot
62 the second import is closed, and the first import of the second artery pot 62 is opened；The dialysis liquid interface and displacement liquid interface connect respectively
Dialyzate bag and displacement liquid bag are connect, the second albumin solution interface that toxin adsorbing mechanism 9 exports is closed；Toxin adsorbing mechanism 9
Outlet waste liquid pool 16 is connected by check valve 28；The waste liquid orifice waste liquid pool 16 of second high flux hemodialysis device 72.
The technical solution further limited is as follows：
The blood pump 11, the first kinetic pump 12, the first ultrafiltrate pump 13, the second kinetic pump 14, the second ultrafiltrate pump 15 are doctor
Use peristaltic pump.
The dialysis check valve 21, displacement check valve 22, purification check valve 23, removing toxic substances check valve 24, first are taken drugs unidirectional
Valve 25, the second drug abuse check valve 26, bypass check valve 27, the first waste liquid check valve 28, third drug abuse check valve 29, the second waste liquid
Check valve 210, input check valve 211, output one-way valve 212 are Medical check valve.
The import of the blood pump 11 is equipped with the first anti-coagulants supply device 31, and the outlet of the second high flux hemodialysis device 72 is equipped with
Second anti-coagulants supply device 32；The first anti-coagulants supply device 31 and the second anti-coagulants supply device 32 are injection
Device.
It connects between the inlet and outlet of the toxin adsorbing mechanism 9 bypass check valve 27, bypasses 27 import of check valve
The import for toxin adsorbing mechanism 9 is held, the port of export of bypass check valve 27 is the outlet of toxin adsorbing mechanism 9, is formed another
Toxin absorption mode.
The outlet of first kinetic pump 12 is connected the first heating arrangements 41, the outlet series connection of second kinetic pump 14
The second heating arrangements 42；First heating arrangements, 41 and second heating arrangements 42 are medicinal blood heating arrangements.
The oscillating device 5 is Medical oscillation device.
The first artery pot 61, the second artery pot 62, third artery pot 63, venous chambers 64, toxin adsorbing mechanism 9 go out
Pressure sensor is respectively equipped in the dialyzate of mouth and the second high flux hemodialysis device 72 outlet 722；Second artery pot, 62 He
Liquid level sensor is respectively equipped on venous chambers 64；The dialyzate bag 81, displacement liquid bag 82, albumin container 10 and waste liquid pool 16
On be respectively equipped with weight sensor；The albumin solution outlet 713 and second of the first high flux hemodialysis device 71 is high-throughput thoroughly
Blood leakage sensor is respectively equipped in the dialyzate outlet 722 of parser 72；The outlet of first heating arrangements 41 and the second heating
The outlet of mechanism 42 is respectively equipped with temperature sensor；The entrance of the output one-way valve 212 is equipped with air bubble sensor.
The carbon adsorption column 911 is medical carbon adsorption column, and the resin absorbing column 912 is medical resin adsorption column.
The first artery pot 61, the second artery pot 62, third artery pot 63 are medical artery pot, and venous chambers 64 are doctor
With venous chambers, the first high flux hemodialysis device 71 and the second high flux hemodialysis device 72 are medical high flux hemodialysis device.
Present system can reduce the loss of itself albumin, prevent external albumin from polluting, realize a variety of adsorbents
Regeneration is repeated and is made full use of, and is improved existing adsorbent service efficiency and systemic toxicity elimination efficiency, is avoided blood and adsorbent
Immune problem caused by contact prevents possible absorbent particles from entering human body and effectively realizes electrolyte balance, discharge
Surplus fluid in excessive moisture and human body in blood（Oedema）, it is cost-effective, shorten treatment time, reduce system loss, increase
Security of system and realization personalized treatment.
The advantageous effects of the present invention embody in the following areas：
1st, when present system works, adsorbent is not in direct contact with blood, reduces damage to haemocyte and to blood
The pollution of liquid, meanwhile, increase the biocompatibility of system.
2nd, this system uses sorbent regeneration system, realizes being used repeatedly for adsorbent, improves the utilization of adsorbent
Rate reduces adsorbent and largely expends, reduce system loss, saves cost.
3rd, this system is separated blood module and albumin module using tunica fibrosa, and adsorbent microparticle is prevented to enter people
Body avoids injury of the adsorbent microparticle to human body.
4th, this system uses the albumin circulatory system, reduces the loss of itself albumin, white in the albumin circulatory system
Albumen does not enter human body, so as to avoid pollution of the external albumin to itself albumin.
5th, this system uses continuous blood purification, and energy Fast-Balance human electrolyte's concentration is quick to remove water in blood
In dissolubility, small molecule toxins, effectively remove the water of patient's body excess so as to eliminate oedema.
6th, this system uses continuous blood purification, can quickly remove in blood in water solubility, small molecule toxins, can be effective
The water of patient's body excess is removed, so as to eliminate oedema.
7th, this system can realize the operation of monitoring whole system, in order to realize that remote control is established by combining monitoring device
Basis is determined.
8th, this system is supplemented using dialyzate（That is blood filtering）With haemodialysis automatic switchover mode, system can be avoided to transport
Personalized treatment is shut down and realized to row.
Description of the drawings
Fig. 1 is present system operating diagram.
Fig. 2 is toxin adsorbing mechanism schematic diagram of the present invention, and 91 toxin absorption modes, 92 without toxin absorption mode.
Fig. 3 is dilution mode schematic diagram before blood purification mechanism B1 of the present invention.
Fig. 4 is dilution mode schematic diagram after blood purification mechanism B2 of the present invention.
System operating diagram when Fig. 5 is adsorbent of the present invention and albumin regeneration.
Serial number in upper figure：Blood pump 11, the first kinetic pump 12, the first ultrafiltrate pump 13, the second kinetic pump 14, the second ultrafiltrate pump
15th, dialysis check valve 21, displacement check valve 22, purification check valve 23, removing toxic substances check valve 24, the first drug abuse check valve 25, second
Drug abuse check valve 26, bypass check valve 27, the first waste liquid check valve 28, third drug abuse check valve 29, the second waste liquid check valve
210th, check valve 211, output one-way valve 212, the first anti-coagulants supply device 31, the second anti-coagulants supply device 32, the are inputted
One heating arrangements 41, the second heating arrangements 42, oscillating mechanism 5, the first artery pot 61, the second artery pot 62, third artery pot 63,
Venous chambers 64, the first high flux hemodialysis device 71, the second high flux hemodialysis device 72, the first blood inlet 711, albumin solution import
712nd, albumin solution exports the 713, first blood and exports the 714, second blood inlet 721, the 722, second blood of dialyzate outlet
Outlet 723, dialyzate bag 81, displacement liquid bag 82, toxin adsorbing mechanism 9, carbon adsorption column 911, resin absorbing column 912, albumin
Container 10, waste liquid pool 16.
Specific embodiment
Below in conjunction with the accompanying drawings, the present invention is further described by embodiment.
Referring to Fig. 1, a kind of multifunctional recycled blood purification system includes blood purification mechanism, dialyzate supplementary mechanism, poison
Plain adsorbing mechanism 9.
Blood purification mechanism includes the first high flux hemodialysis device 71 and the second high flux hemodialysis device 72 of series connection, the first high pass
It is medical high flux hemodialysis device to measure 71 and second high flux hemodialysis device 72 of dialyzer.
First blood inlet 711 of the first high flux hemodialysis device 71 is sequentially connected in series the first artery pot 61, blood pump 11 and defeated
Enter check valve 211, the import of input check valve 211 is the import of blood purification mechanism.
The albumin solution of first high flux hemodialysis device 71 exports 713 the first ultrafiltrate pump 13, first by being sequentially connected in series
Drug abuse check valve 25 connects the import of toxin adsorbing mechanism 9, the white egg of the first high flux hemodialysis device 71 with the second artery pot 62
White solution inlet port 712 connects the first albumin solution interface by the second kinetic pump 14 of series connection.
The first blood outlet 714 of first high flux hemodialysis device 71 and the second blood inlet of the second high flux hemodialysis device 72
Third of connecting between 721 artery pot 63.
The dialyzate outlet 722 of second high flux hemodialysis device 72 passes through the second ultrafiltrate pump 15 being sequentially connected in series and the second waste liquid
Check valve 210 is connected to waste liquid interface；The second blood outlet 723 of second high flux hemodialysis device 72 is sequentially connected in series venous chambers
64th, output one-way valve 212.
Wherein input terminal of the entrance of input check valve 211 for multifunctional recycled blood purification system, output one-way valve 212
Outlet for multifunctional recycled blood purification system output terminal.
Referring to Fig. 3, dialyzate supplementary mechanism includes the first kinetic pump 12, dialysis check valve 21, displacement check valve 22 and net
Change check valve 23.Dialysis check valve 21 and displacement check valve 22 are connected in parallel on the import of the first kinetic pump 12, dialysis check valve 21
Inlet communication dialyzate bag 81, and the inlet communication of displacement check valve 22 displacement liquid bag 82；The outlet of purification check valve 23 is
The outlet of dialyzate supplementary mechanism, the outlet of dialyzate supplementary mechanism or connects the import of third artery pot 63 or connects quiet
The import of arteries and veins pot 64.
Referring to Fig. 2, toxin adsorbing mechanism includes the second drug abuse check valve 26, carbon adsorption column 911 and the resin adsorption of series connection
Column 912, carbon adsorption column 911 are medical carbon adsorption column, and resin absorbing column 912 is medical resin adsorption column.The carbon adsorption column of series connection
911 and resin absorbing column 912 be located on oscillating mechanism 5, oscillating device 5 be Medical oscillation device.The input end of carbon adsorption column 911 is
The import of toxin adsorbing mechanism 9, the port of export of resin absorbing column 912 are the outlet of toxin adsorbing mechanism 9, form a kind of toxin and inhale
Attached pattern.
Another toxin absorption mode, i.e., bypass check valve of connecting between the inlet and outlet of toxin adsorbing mechanism 9
27,27 input end of bypass check valve is the import of toxin adsorbing mechanism 9, and the port of export of bypass check valve 27 is toxin adsorbing mechanism
9 outlet.
The entrance of toxin adsorbing mechanism 9 is equipped with the second artery pot 62, and the first import of the second artery pot 62 passes through removing toxic substances
Check valve 24 connects the outlet of the first kinetic pump 12, and the second inlet communication of the second artery pot 62 the first drug abuse check valve 25
Outlet；The outlet of toxin adsorbing mechanism 9 connects the second albumin solution interface or by by third drug abuse check valve 29
One waste liquid check valve 28 connects waste liquid pool 16.
During work, the first albumin solution interface and the second albumin solution interface are respectively communicated with the two of albumin container 10
A port.
Referring to Fig. 3 and Fig. 4, the input check valve 211, blood pump 11, the first artery pot 61, the first high flux hemodialysis device
71st, third artery pot 63, the second high flux hemodialysis device 72, venous chambers 64 and output one-way valve 212 form blood circulation mechanism；
Referring to Fig. 1, the first high flux hemodialysis device 71, the first ultrafiltrate pump 13, the first drug abuse check valve 25 and second are dynamic
Arteries and veins pot 62, toxin adsorbing mechanism 9, third drug abuse check valve 29, albumin solution container 10, the second kinetic pump 14 form albumin
Circulation mechanism；
Referring to Fig. 1, the dialysis check valve 21, dialyzate bag 81, displacement check valve 22, displacement liquid bag 82, the first power
Pump 12, removing toxic substances check valve 24, the second artery pot 62, toxin adsorbing mechanism 9, the first waste liquid check valve 28, waste liquid pool 16 are formed and are inhaled
Attached dose and albumin regeneration sector.
The blood pump 11, the first kinetic pump 12, the first ultrafiltrate pump 13, the second kinetic pump 14, the second ultrafiltrate pump 15 are doctor
Use peristaltic pump.
The dialysis check valve 21, displacement check valve 22, purification check valve 23, removing toxic substances check valve 24, first are taken drugs unidirectional
Valve 25, the second drug abuse check valve 26, bypass check valve 27, the first waste liquid check valve 28, third drug abuse check valve 29, the second waste liquid
Check valve 210, input check valve 211, output one-way valve 212 are Medical check valve.
The import of the blood pump 11 is equipped with the first anti-coagulants supply device 31, and the outlet of the second high flux hemodialysis device 72 is equipped with
Second anti-coagulants supply device 32；First anti-coagulants supply device 31 and the second anti-coagulants supply device 32 are syringe.
The outlet of first kinetic pump 12 is connected the first heating arrangements 41, and the outlet of second kinetic pump 14 connects
Two heating arrangements 42；First heating arrangements, 41 and second heating arrangements 42 are medicinal blood heating arrangements.
The first artery pot 61, the second artery pot 62, third artery pot 63, venous chambers 64, toxin adsorbing mechanism 9 go out
Pressure sensor is respectively equipped in the dialyzate of mouth and the second high flux hemodialysis device 72 outlet 722；Second artery pot, 62 He
Liquid level sensor is respectively equipped on venous chambers 64；The dialyzate bag 81, displacement liquid bag 82, albumin container 10 and waste liquid pool 16
On be respectively equipped with weight sensor；The albumin solution outlet 713 and second of the first high flux hemodialysis device 71 is high-throughput thoroughly
Blood leakage sensor is respectively equipped in the dialyzate outlet 722 of parser 72；The outlet of first heating arrangements 41 and the second heating
The outlet of mechanism 42 is respectively equipped with temperature sensor；The entrance of the output one-way valve 212 is equipped with air bubble sensor.
The first artery pot 61, the second artery pot 62, third artery pot 63 are medical artery pot, and venous chambers 64 are doctor
Use venous chambers.
The operation principle of the present invention is illustrated respectively below.
It needs to regenerate the albumin combined with toxin while for removing septicemia element, referring to Fig. 1, check valve of dialysing
21st, check valve 22, purification check valve 23, the first drug abuse check valve 25, the second drug abuse check valve 26, third drug abuse check valve are replaced
29th, waste liquid check valve 210, input check valve 211 and output one-way valve 212 are opened, and operation principle is as follows：
（1）Blood of human body flows through input check valve 211, is passed through after the first anti-coagulants supply device 31 supplements anti-coagulants after
Blood pump 11 is pumped into the first artery pot 61, subsequently enters the first high flux hemodialysis device 71,71 membrane filtration of the first high flux hemodialysis device
The solution containing toxin gone out flows into the second artery pot 62 through the first ultrafiltrate pump 13.
（2）Referring to Fig. 2, then the solution containing toxin flows into toxin adsorbent equipment 9 through the second artery pot 62, is inhaled using carbon
Toxin under the operating mode of attached column 911 and resin absorbing column 912 in absorbing toxin solution；
（3）By the solution after Adsorption toxin after albumin container 10 supplements albumin, pass through the second kinetic pump 14
It is pumped into the second heating arrangements 42 to heat, makes albumin solution close to body temperature.
（4）The weight of albumin container 10 is measured by weight sensor, and passes through and adjusts the first ultrafiltrate pump 13 and second
Kinetic pump 14 controls the flow of albumin solution and the ultrafiltration volume of the first high flux hemodialysis device 71.
（5）The solution for supplementing albumin exports the entrance for flowing into the first high flux hemodialysis device 71 through the second heating arrangements 42
712。
（6）Referring to Fig. 3, by blood purification module remove moisture extra in blood and it is water-soluble in, small molecule poison
When plain, the i.e. preceding dilution module of B1 patterns is flowed into third artery pot 63 and led to by the blood of Adsorption and albumin combination toxin
Dialyzate supplementary mechanism supplement dialyzate is crossed, the second high flux hemodialysis device 72 is subsequently flowed into, is removed in blood by blood purification
Extra moisture and it is water-soluble in, small molecule toxins, then remove the blood of toxin and excessive moisture through venous chambers 64 and defeated
Go out check valve 212 and flow back to human body；Wherein, weight change of the waste liquid pool 16 within given time is measured by weight sensor to adjust
Save the flow of the second ultrafiltrate pump 15.
Embodiment 2
It needs to regenerate the albumin combined with toxin while for removing septicemia element, referring to Fig. 1, Fig. 2 and Fig. 4；
From fig. 4, it can be seen that step（6）Extra moisture and water-soluble middle or small is removed in blood by blood purification module
During molecule toxin, using dilution mode after B2, adsorbed or the blood of removal not to be adsorbed and albumin combination toxin also can be through
Third artery pot 63 flow directly into the second high flux hemodialysis device 72 removal blood extra moisture and it is water-soluble in, small molecule
Toxin subsequently flows into venous chambers 64 and supplements dialyzate by dialyzate supplementary mechanism simultaneously.
Other steps（1）, step（2）, step（3）, step（4）, step（5）With in embodiment 1.
Embodiment 3
Need to regenerate the albumin that is combined with toxin while for removing septicemia element, referring to Fig. 1, Fig. 2, Fig. 3 and
Fig. 4.
By Fig. 3 and Fig. 4 as it can be seen that step（6）Extra moisture and water-soluble is removed in blood by blood purification module
In, small molecule toxins when, while using dilution mode after dilution mode before B1 and B2, adsorb or removal not to be adsorbed and white egg
The white blood with reference to toxin is through third artery pot 63 and passes through dialyzate supplementary mechanism supplement dialyzate, subsequently flows into the second high pass
Measure dialyzer 72 remove in blood extra moisture and it is water-soluble in, small molecule toxins, subsequently flow into venous chambers 64 simultaneously by
Dialyzate supplementary mechanism supplements dialyzate.
Other steps（1）, step（2）, step（3）, step（4）, step（5）With in embodiment 1.
Embodiment 4
For only purifying blood, when not needing to the albumin that regeneration is combined with toxin, referring to Fig. 1, Fig. 2 and Fig. 3, dialysis is single
To valve 21, displacement check valve 22, purification check valve 23, the first drug abuse check valve 25, bypass check valve 27, third drug abuse check valve
29th, waste liquid check valve 210, input check valve 211 and output one-way valve 212 are opened, and operation principle is as follows：
Referring to Fig. 2, by the step in embodiment 1（1）Afterwards, when not needing to recycle the albumin combined with toxin, step
Suddenly（2）Then the solution containing toxin flows into toxin adsorbent equipment 9 through the second artery pot 62, connects in toxin adsorbent equipment 9
Bypass that the toxin under the operating mode of check valve 27 in toxin soiutions is not to be adsorbed to be directly flowed through.
Other steps（1）, step（3）, step（4）, step（5）, step（6）With embodiment 1.
Embodiment 5
For only purifying blood, when not needing to the albumin that regeneration is combined with toxin, referring to Fig. 1, Fig. 2, Fig. 3 and Fig. 4,
Step in the present embodiment（1）, step（3）, step（4）, step（5）, with embodiment 1, step（2）With embodiment 4,
Step（6）With embodiment 2.
Embodiment 6
For only purifying blood, when not needing to the albumin that regeneration is combined with toxin, referring to Fig. 1, Fig. 2, Fig. 3 and Fig. 4,
Step in the present embodiment（1）, step（3）, step（4）, step（5）With embodiment 1, step（2）With embodiment 4
In, step（6）With embodiment 3.
Embodiment 7
When being regenerated for adsorbent and albumin, referring to Fig. 5.Check valve 21, displacement check valve 22, removing toxic substances dialyse unidirectionally
Valve 24, check valve 28 are opened；
Dialyzate in dialyzate bag 81 and displacement liquid bag 82 through the effect of the first kinetic pump 12 flow through the first heating arrangements 41,
First drug abuse check valve 24, the second artery pot 62 enter toxin adsorbent equipment 5, by the carbon Filter column being placed on oscillating device
911, the toxin of carbon adsorbent desorption and albumin combination, later solution inflow is placed in the resin Filter column on oscillating device
912, the toxin of resin sorbent desorption and albumin combination, subsequent solution flows into waste liquid pool 16 through check valve 28, continues this
Item operation is washed totally until the toxin adsorbed on the adsorbent in carbon Filter column 911 and resin Filter column 912, completes to inhale
Attached dose and albumin regenerative operation.
Above-described embodiment 1-3 is suitable for needing to regenerate the situation of albumin combined with toxin while purification blood,
Step（1）-（5）It is identical, step（6）Difference can be chosen according to the state of an illness of patient and apply in a 1-3（6）.
Above-described embodiment 4-6 is suitable for only purifying blood, does not need to the situation of albumin that regeneration is combined with toxin, step
Suddenly（1）-（5）It is identical, step（6）Difference can be chosen according to the state of an illness of patient and apply in a 4-6（6）.
Above-described embodiment 7 is suitable for the albumin that recycling is combined with toxin.
Claims (10)
1. a kind of multifunctional recycled blood purification system, it is characterised in that：Including blood purification mechanism, dialyzate supplementary mechanism,
Toxin adsorbing mechanism（9）；
The blood purification mechanism includes the first high flux hemodialysis device of series connection（71）With the second high flux hemodialysis device（72）；
The first high flux hemodialysis device（71）The first blood inlet（711）It is sequentially connected in series the first artery pot（61）, blood pump
（11）With input check valve（211）, input check valve（211）Import be blood purification mechanism import；
First high flux hemodialysis device（71）Albumin solution outlet（713）Pass through the first ultrafiltrate pump being sequentially connected in series（13）,
One drug abuse check valve（25）With the second artery pot（62）Connect toxin adsorbing mechanism（9）Import, the first high flux hemodialysis device
（71）Albumin solution import（712）Pass through the second kinetic pump of series connection（14）Connect the first albumin solution interface；
First high flux hemodialysis device（71）The first blood outlet（714）With the second high flux hemodialysis device（72）The second blood into
Mouthful（721）Between connect third artery pot（63）；
The second high flux hemodialysis device（72）Dialyzate outlet（722）Pass through the second ultrafiltrate pump being sequentially connected in series（15）With
Two waste liquid check valves（210）It is connected to waste liquid interface；Second high flux hemodialysis device（72）The second blood outlet（723）It goes here and there successively
Join venous chambers（64）, output one-way valve（212）；
The input check valve（211）Entrance be the multifunctional recycled blood purification system input terminal, output one-way valve
（212）Outlet for the multifunctional recycled blood purification system output terminal；
The dialyzate supplementary mechanism includes the first kinetic pump（12）, dialysis check valve（21）, displacement check valve（22）And purification
Check valve（23）；Dialysis check valve（21）With displacement check valve（22）It is connected in parallel on the first kinetic pump（12）Import, dialysis is unidirectional
Valve（21）Inlet communication dialyzate bag（81）, replace check valve（22）Inlet communication displacement liquid bag（82）；Purification is single
To valve（23）Outlet of the outlet for dialyzate supplementary mechanism, the outlet of dialyzate supplementary mechanism or connect third artery pot
（63）Import or connect venous chambers（64）Import；
The toxin adsorbing mechanism（9）The second drug abuse check valve including series connection（26）, carbon adsorption column（911）And resin absorbing column
（912）, the carbon adsorption column of series connection（911）And resin absorbing column（912）Positioned at oscillating mechanism（5）On；Wherein carbon adsorption column（911）
Input end be toxin adsorbing mechanism（9）Import, resin absorbing column（912）The port of export be toxin adsorbing mechanism（9）Go out
Mouthful, form a kind of toxin absorption mode；
Toxin adsorbing mechanism（9）Entrance be equipped with the second artery pot（62）, the second artery pot（62）The first import pass through solution
Malicious check valve（24）Connect the first kinetic pump（12）Outlet, the second artery pot（62）The second inlet communication the first drug abuse single
To valve（25）Outlet；
Toxin adsorbing mechanism（9）Outlet taken drugs check valve by third（29）It connects the second albumin solution interface or passes through
First waste liquid check valve（28）Connect waste liquid pool（16）；
During work, the first albumin solution interface and the second albumin solution interface are respectively communicated with albumin container（10）Two
Port；
The input check valve（211）, blood pump（11）, the first artery pot（61）, the first high flux hemodialysis device（71）, third artery
Pot（63）, the second high flux hemodialysis device（72）, venous chambers（64）And output one-way valve（212）Form blood circulation mechanism；
The first high flux hemodialysis device（71）, the first ultrafiltrate pump（13）, the first drug abuse check valve（25）With the second artery pot
（62）, toxin adsorbing mechanism（9）, third drug abuse check valve（29）, albumin solution container（10）, the second kinetic pump（14）It forms
Albumin circulation mechanism；
The dialysis check valve（21）, dialyzate bag（81）, displacement check valve（22）, displacement liquid bag（82）, the first kinetic pump
（12）, removing toxic substances check valve（24）, the second artery pot（62）, toxin adsorbing mechanism（9）, the first waste liquid check valve（28）, waste liquid pool
（16）Form adsorbent and albumin regeneration sector；
The system realizes following operate：
During for removing septicemia element, blood circulation mechanism, blood purification mechanism, dialyzate supplementary mechanism, toxin adsorption machine
Structure（9）It works with albumin circulation mechanism, adsorbent and albumin regeneration sector are stopped；Second artery pot（62）First
Import is closed, the second artery pot（62）The second import connect；When removing with albumin combination toxoid, described first is high-throughput
Dialyzer（71）The first albumin solution interface and toxin adsorbing mechanism（9）Second albumin solution interface of outlet connects respectively
Lead to albumin container（10）；When removing in blood not with albumin combination toxoid and extra moisture, dialyzate supplement machine
Structure works, the second high flux hemodialysis device（72）The second blood inlet（721）Connect third artery pot（63）Outlet,
Second high flux hemodialysis device（72）Dialyzate outlet（722）Connect waste liquid pool（16）；
When wherein, for blood circulation, blood of human body is through inputting check valve（211）Input system, through output one-way valve（212）It is defeated
Human body is flowed back to after going out system；When supplementing dialyzate, dialysis liquid interface and displacement liquid interface connect dialyzate bag respectively（81）With put
Change liquid bag（82）, there are three types of connection modes for the outlet of dialyzate supplementary mechanism, individually connect third artery pot（63）Import
The first dialyzate supplement mode is formed, individually connects venous chambers（64）Import formed second of dialyzate supplement mode,
Third artery pot can also be connected simultaneously（63）Import and venous chambers（64）Import formed the third dialyzate supplement mould
Formula；When toxin adsorbs, the toxin adsorbing mechanism（9）Entrance connect the second artery pot（62）Outlet, toxin adsorption machine
Structure（9）Outlet albumin container by the second albumin solution orifice（10）；
When being regenerated for adsorbent and albumin, blood circulation mechanism, dialyzate supplementary mechanism, blood purification mechanism and albumin
Circulation mechanism is stopped, toxin adsorbing mechanism（9）It works with adsorbent and albumin regeneration sector；The second artery pot
（62）The second import close, the second artery pot（62）The first import open；The dialysis liquid interface and displacement liquid interface point
Not Lian Jie dialyzate bag and displacement liquid bag, toxin adsorbing mechanism（9）Second albumin solution interface of outlet is closed；Toxin adsorbs
Mechanism（9）Outlet pass through check valve（28）Connect waste liquid pool（16）；Second high flux hemodialysis device（72）Waste liquid interface connect
Logical waste liquid pool（16）.
2. a kind of multifunctional recycled blood purification system according to claim 1, it is characterised in that：The blood pump（11）,
One kinetic pump（12）, the first ultrafiltrate pump（13）, the second kinetic pump（14）, the second ultrafiltrate pump（15）It is medical peristaltic pump.
3. a kind of multifunctional recycled blood purification system according to claim 1, it is characterised in that：The dialysis check valve
（21）, displacement check valve（22）, purification check valve（23）, removing toxic substances check valve（24）, the first drug abuse check valve（25）, second take drugs
Check valve（26）, bypass check valve（27）, the first waste liquid check valve（28）, third drug abuse check valve（29）, the second waste liquid it is unidirectional
Valve（210）, input check valve（211）, output one-way valve（212）It is Medical check valve.
4. a kind of multifunctional recycled blood purification system according to claim 1, it is characterised in that：The blood pump（11）Into
Mouth is equipped with the first anti-coagulants supply device（31）, the second high flux hemodialysis device（72）Outlet be equipped with the second anti-coagulants supply device
（32）；The first anti-coagulants supply device（31）With the second anti-coagulants supply device（32）It is syringe.
5. a kind of multifunctional recycled blood purification system according to claim 1, it is characterised in that：The toxin adsorbing mechanism
（9）Inlet and outlet between connect bypass check valve（27）, bypass check valve（27）Input end is toxin adsorbing mechanism（9）
Import, bypass check valve（27）The port of export be toxin adsorbing mechanism（9）Outlet, form another toxin absorption mode.
6. a kind of multifunctional recycled blood purification system according to claim 1, it is characterised in that：First kinetic pump
（12）Outlet connect the first heating arrangements（41）, second kinetic pump（14）Outlet connect the second heating arrangements
（42）；First heating arrangements（41）With the second heating arrangements（42）It is medicinal blood heating arrangements.
7. a kind of multifunctional recycled blood purification system according to claim 1, it is characterised in that：The oscillating mechanism（5）
For Medical oscillation device.
8. a kind of multifunctional recycled blood purification system according to claim 1, it is characterised in that：The first artery pot
（61）, the second artery pot（62）, third artery pot（63）, venous chambers（64）, toxin adsorbing mechanism（9）Outlet and the second high pass
Measure dialyzer（72）Dialyzate outlet（722）On be respectively equipped with pressure sensor；The second artery pot（62）And venous chambers
（64）On be respectively equipped with liquid level sensor；The dialyzate bag（81）, displacement liquid bag（82）, albumin container（10）And waste liquid pool
（16）On be respectively equipped with weight sensor；The first high flux hemodialysis device（71）Albumin solution outlet（713）With second
High flux hemodialysis device（72）Dialyzate outlet（722）On be respectively equipped with blood leakage sensor；First heating arrangements（41）Outlet
With the second heating arrangements（42）Outlet be respectively equipped with temperature sensor；The output one-way valve（212）Entrance be equipped with gas
Steep sensor.
9. a kind of multifunctional recycled blood purification system according to claim 1, it is characterised in that：The carbon adsorption column
（911）For medical carbon adsorption column, the resin absorbing column（912）For medical resin adsorption column.
10. a kind of multifunctional recycled blood purification system according to claim 1, it is characterised in that：The first artery pot
（61）, the second artery pot（62）, third artery pot（63）It is medical artery pot, venous chambers（64）For medical vein pot, first
High flux hemodialysis device（71）With the second high flux hemodialysis device（72）It is medical high flux hemodialysis device.
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| JP7257964B2 (en) * | 2017-11-29 | 2023-04-14 | 日機装株式会社 | Dialysis system operating method and dialysis system |
| CN108785773B (en) * | 2018-06-13 | 2024-04-09 | 上海健康医学院 | Efficient purifying and regenerating system for dialysate |
| CN110152090A (en) * | 2019-06-18 | 2019-08-23 | 长沙医学院 | A blood transfusion device for autologous blood supply and circulation purification |
| CN111035826B (en) * | 2019-12-25 | 2025-01-24 | 天津市第三中心医院 | A blood purification device combining membrane separation and perfusion coupling |
| CN112007226A (en) * | 2020-07-13 | 2020-12-01 | 北京西峰科技有限责任公司 | Blood extracorporeal circulation life support system |
| CN116374995A (en) * | 2023-05-24 | 2023-07-04 | 福建省鑫森炭业股份有限公司 | A new type of carbon material for removing small molecules in the process of dialysate circulation and regeneration and its preparation method |
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| CN101098722A (en) * | 2005-02-17 | 2008-01-02 | 弗雷森纽斯医疗护理德国有限责任公司 | Device for the removal of substances form liquids in particular blood |
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| US8038638B2 (en) * | 2004-02-23 | 2011-10-18 | Hemolife Medical, Inc. | Plasma detoxification and volume control system and methods of use |
| JP4493097B2 (en) * | 2005-10-14 | 2010-06-30 | 旭化成クラレメディカル株式会社 | Continuous blood filtration device |
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| CN101098722A (en) * | 2005-02-17 | 2008-01-02 | 弗雷森纽斯医疗护理德国有限责任公司 | Device for the removal of substances form liquids in particular blood |
| CN103251996A (en) * | 2013-04-02 | 2013-08-21 | 周春华 | Portable multiple organ support integration machine |
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