CN102488746A - Compound propolis composition for treating swine infectious atrophic rhinitis and preparation method thereof - Google Patents
Compound propolis composition for treating swine infectious atrophic rhinitis and preparation method thereof Download PDFInfo
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- CN102488746A CN102488746A CN2011104460782A CN201110446078A CN102488746A CN 102488746 A CN102488746 A CN 102488746A CN 2011104460782 A CN2011104460782 A CN 2011104460782A CN 201110446078 A CN201110446078 A CN 201110446078A CN 102488746 A CN102488746 A CN 102488746A
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- 208000015181 infectious disease Diseases 0.000 title claims abstract description 21
- 201000008283 Atrophic Rhinitis Diseases 0.000 title claims abstract description 20
- 206010039088 Rhinitis atrophic Diseases 0.000 title claims abstract description 20
- 230000002458 infectious effect Effects 0.000 title claims abstract description 20
- 150000001875 compounds Chemical class 0.000 title claims abstract description 18
- 241000241413 Propolis Species 0.000 title claims abstract description 17
- 229940069949 propolis Drugs 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 241000282898 Sus scrofa Species 0.000 title abstract 3
- 238000005303 weighing Methods 0.000 claims abstract description 12
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 6
- 229910052957 realgar Inorganic materials 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims abstract description 4
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- 235000014435 Mentha Nutrition 0.000 claims description 5
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- 239000003814 drug Substances 0.000 abstract description 11
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- 229940079593 drug Drugs 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 235000003092 Artemisia dracunculus Nutrition 0.000 abstract 1
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- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
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- 238000007664 blowing Methods 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a compound propolis composition for treating swine infectious atrophic rhinitis and a preparation method thereof, which relates to the field of animal medicines. The preparation method for the composition comprises the following steps: (1) respectively carrying out ultrafine crushing on all the components in a prescription and screening all the crushed components with a 700-mesh sieve; (2) weighing 15 to 35 parts by weight of propolis, 15 to 35 parts by weight of fructus gleditsiae abnormalis, 15 to 35 parts by weight of dahurian angelica root and 15 to 35 parts by weight of Asarum herb and uniformly mixing the components for 5 to 10 min; (3) weighing 15 to 45 parts by weight of borneol, 10 to 20 parts by weight of realgar, 15 to 45 parts by weight of mint and 10 to 30 parts by weight of tarragon and uniformly mixing the components for 5 to 10 min; and (4) combining compositions prepared in step (2) and (3) and continuing to uniformly mix the compositions for 10 to 15 min so as to obtain the compound propolis composition. The beneficial effects of the invention are as follows: composition is reasonable; preparation is simple; the compound propolis composition has the advantages of no toxic and side effects, no pollution, no drug residue, no drug resistance, a unique application method of direct blowing of the compound propolis composition into noses of infected animals, ultrafine crushing, high bioavailability and a very remarkable curative effect, and according to results of clinical practice, the compound propolis composition has special efficacy in treating swine infectious atrophic rhinitis.
Description
Technical field
The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to the treatment pig infectious atrophic rhinitis and preparation method thereof.
Background technology
Pig infectious atrophic rhinitis is a kind of universal pandemic serious contact upper respiratory infectious disease that is caused by pig toxigenicity pasteurella multocida and bronchus deteriorated blood bordetella bacilli, is characteristic with sneeze, nasal bone distortion, turbinates atrophy or disappearance and deviation of nasal septum clinically.The pig of various ages and kind all can be taken place, and all between 2%-10%, infected pigs can cause serious feed consumption to increase, deliver for sale delay etc. to case fatality rate.Primary disease all can take place throughout the year, is one of principal disease of serious harm pig industry.
This disease almost spreads all over all countries of raising pigs of the world, distributes very extensively.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug since life-time service drug residue is arranged and be prone to produce drug resistance, its clinical effectiveness worse and worse, and drug residue cause exporting limited healthy with the harm people, thereby make the use of antimicrobial drug receive very big restriction.
Therefore researching and developing a kind of specific medicament of treating the drug residue free of pig infectious atrophic rhinitis, the generation that has no drug resistance is one of this field scientific research technical staff new problem anxious to be solved.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no drug resistance and the compound bee-glue composition of effective treatment pig infectious atrophic rhinitis of drug residue and preparation method thereof.
Following for realizing the embodiment that above-mentioned purpose the present invention adopted: a kind of compound bee-glue composition of treating pig infectious atrophic rhinitis, by following component by weight mixed preparing form: propolis 15-35 part, Fructus Gleditsiae Abnormalis 15-35 part, Radix Angelicae Dahuricae 15-35 part, Herba Asari 15-35 part, Borneolum Syntheticum 15-45 part, Realgar 10-20 part, Herba Menthae 15-45 part, Folium Artemisiae Argyi 10-30 part.
On the basis of such scheme, said various component optimum ratio amounts are: 25 parts of propolis, 25 parts of Fructus Gleditsiae Abnormalis, 25 parts of the Radixs Angelicae Dahuricae, 25 parts of Herba Asaris, 30 parts of Borneolum Syntheticums, 15 parts of Realgars, 30 parts of Herba Menthaes, 20 parts of Folium Artemisiae Argyis.
A kind of method for preparing of treating the compound bee-glue composition of pig infectious atrophic rhinitis, carry out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-35 part, Fructus Gleditsiae Abnormalis 15-35 part, Radix Angelicae Dahuricae 15-35 part, Herba Asari 15-35 by weight, mix 5-10 minute to even;
(3) take by weighing Borneolum Syntheticum 15-45 part, Realgar 10-20 part, Herba Menthae 15-45 part, Folium Artemisiae Argyi 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is following:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Fructus Gleditsiae Abnormalis: become, hot, warm, return lung, stomach, large intestine channel, the function of have sensible, clearing away phlegm, searching wind; Cure mainly that apoplexy locked mouth, wind syndrome of head, wind are chronic, sore throat, phlegm dyspnea, carbuncle etc.
The Radix Angelicae Dahuricae: hot, warm, return lung, stomach, large intestine channel, have the function of diffusing wind damp eliminating, detumescence and apocenosis, understand things pain-stopping; Cure mainly affection of exogenous wind-cold, rheumatic arthralgia, the yellow furunculosis of skin ulcer, rhinocleisis etc.
Herba Asari: hot, warm, return lung, the heart, kidney channel, have the function of the cold expelling that induces sweat, understand things pain-stopping, warming the lung to resolve fluid-retention; Cure mainly anemofrigid cold, cold type of pain, rheumatic arthralgia, the cold cough of expense etc.
Borneolum Syntheticum: hot, bitter, be slightly cold, GUIXIN, spleen, lung meridian have the function of sensible refreshment, heat-clearing and fire-dispersing, reducing swelling and alleviating pain; Cure mainly coma convulsions, laryngopharynx swelling and pain, heat in the heart tongue boil, conjunctival congestion cataracta, sore swollen toxin etc.
Realgar: hot, warm,, return large intestine, Liver Channel, have the function of detoxifcation parasite killing, removing dampness and eliminating phlegm; Cure mainly carbuncle sore tumefacting virus, abdominal pain due to worm stagnation, scabies etc.
Herba Menthae: hot, cool, return lung, Liver Channel, have the function of wind-dispelling heat-dissipating, the cleaning head, sore-throat relieving, rash; Cure mainly affection due to external wind and heat, laryngopharynx swelling and pain, conjunctival congestion, rubella etc.
Folium Artemisiae Argyi: hot, bitter, warm, return spleen, liver, kidney channel, have the function of dispersing cold for relieving pain, warming the meridian for stopping bleeding; Cure mainly anemofrigid-damp arthralgia, tripe abdomen cold type of pain etc.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to pathogenic microorganism, clinical symptoms and the pathological change of pig infectious atrophic rhinitis, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and method for using is unique, directly be blown into and suffer from the poultry nostril, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory; Optimize this eight flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves; The treatment pig infectious atrophic rhinitis there is specially good effect; And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound bee-glue composition of treating pig infectious atrophic rhinitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 150 parts of propolis, 150 parts of Fructus Gleditsiae Abnormalis, 150 parts of the Radixs Angelicae Dahuricae, 150 parts of Herba Asaris by weight, mix 5-10 minute to even;
(3) take by weighing 150 parts of Borneolum Syntheticums, 100 parts of Realgars, 150 parts of Herba Menthaes, 100 parts of Folium Artemisiae Argyis by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition of treating pig infectious atrophic rhinitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 250 parts of propolis, 250 parts of Fructus Gleditsiae Abnormalis, 250 parts of the Radixs Angelicae Dahuricae, 250 parts of Herba Asaris by weight, mix 5-10 minute to even;
(3) take by weighing 300 parts of Borneolum Syntheticums, 150 parts of Realgars, 300 parts of Herba Menthaes, 150 parts of Folium Artemisiae Argyis by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition of treating pig infectious atrophic rhinitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 350 parts of propolis, 350 parts of Fructus Gleditsiae Abnormalis, 350 parts of the Radixs Angelicae Dahuricae, 350 parts of Herba Asaris by weight, mix 5-10 minute to even;
(3) take by weighing 450 parts of Borneolum Syntheticums, 200 parts of Realgars, 450 parts of Herba Menthaes, 300 parts of Folium Artemisiae Argyis by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Product of the present invention directly is blown in the nostril, both sides of ill pig every side 1-2 gram, every day 2-3 time, logotype 3-5 day.
Table is the field applicable cases contrast of the present invention and other medicines treatment pig infectious atrophic rhinitis:
| Numbering | Group | Case fatality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 8.5 | 64.0 | 27.5 |
| II | The pig BIYANKANG looses and organizes | 5.7 | 81.5 | 12.8 |
| III | Present composition group | 4.5 | 90.2 | 5.3 |
This clinical effectiveness is through statistical analysis, and present composition treatment group is loose to organize with the pig BIYANKANG and compared difference extremely significantly (P＜0.01) aspect the cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment pig infectious atrophic rhinitis and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound bee-glue composition of treating pig infectious atrophic rhinitis, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Fructus Gleditsiae Abnormalis 15-35 part, Radix Angelicae Dahuricae 15-35 part, Herba Asari 15-35 part, Borneolum Syntheticum 15-45 part, Realgar 10-20 part, Herba Menthae 15-45 part, Folium Artemisiae Argyi 10-30 part.
2. the compound bee-glue composition of treatment pig infectious atrophic rhinitis according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Fructus Gleditsiae Abnormalis, 25 parts of the Radixs Angelicae Dahuricae, 25 parts of Herba Asaris, 30 parts of Borneolum Syntheticums, 15 parts of Realgars, 30 parts of Herba Menthaes, 20 parts of Folium Artemisiae Argyis.
3. the method for preparing of the compound bee-glue composition of a treatment pig infectious atrophic rhinitis according to claim 1 and 2 is characterized in that carrying out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-35 part, Fructus Gleditsiae Abnormalis 15-35 part, Radix Angelicae Dahuricae 15-35 part, Herba Asari 15-35 part by weight, mix 5-10 minute to even;
(3) take by weighing Borneolum Syntheticum 15-45 part, Realgar 10-20 part, Herba Menthae 15-45 part, Folium Artemisiae Argyi 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110446078.2A CN102488746B (en) | 2011-12-28 | 2011-12-28 | Compound propolis composition for treating swine infectious atrophic rhinitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110446078.2A CN102488746B (en) | 2011-12-28 | 2011-12-28 | Compound propolis composition for treating swine infectious atrophic rhinitis and preparation method thereof |
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| CN102488746A true CN102488746A (en) | 2012-06-13 |
| CN102488746B CN102488746B (en) | 2014-05-28 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666422A (en) * | 2013-11-28 | 2015-06-03 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition for treating rhinitis of swine and preparation method thereof |
| CN105770857A (en) * | 2014-12-22 | 2016-07-20 | 天津嘉创生物科技有限公司 | Nose-insufflating traditional Chinese medicine powder for swine treating infectious atrophic rhinitis and preparation method thereof |
| CN106689758A (en) * | 2017-03-06 | 2017-05-24 | 长沙瑞多康生物科技有限公司 | Feed for preventing swine infectious atrophic rhinitis |
| CN106880663A (en) * | 2017-03-06 | 2017-06-23 | 长沙瑞多康生物科技有限公司 | A kind of composition of prevention infectious atrophic rhinitis of pig |
| CN106901018A (en) * | 2017-03-06 | 2017-06-30 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention infectious atrophic rhinitis of pig |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1751730A (en) * | 2004-09-20 | 2006-03-29 | 曹蛟 | Traditional Chinese medicine for treating anaphylactic rhinitis and its prepn. method |
| CN1850190A (en) * | 2006-02-24 | 2006-10-25 | 徐利洪 | Rhinitis ointment and preparation method thereof |
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2011
- 2011-12-28 CN CN201110446078.2A patent/CN102488746B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1751730A (en) * | 2004-09-20 | 2006-03-29 | 曹蛟 | Traditional Chinese medicine for treating anaphylactic rhinitis and its prepn. method |
| CN1850190A (en) * | 2006-02-24 | 2006-10-25 | 徐利洪 | Rhinitis ointment and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666422A (en) * | 2013-11-28 | 2015-06-03 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition for treating rhinitis of swine and preparation method thereof |
| CN105770857A (en) * | 2014-12-22 | 2016-07-20 | 天津嘉创生物科技有限公司 | Nose-insufflating traditional Chinese medicine powder for swine treating infectious atrophic rhinitis and preparation method thereof |
| CN106689758A (en) * | 2017-03-06 | 2017-05-24 | 长沙瑞多康生物科技有限公司 | Feed for preventing swine infectious atrophic rhinitis |
| CN106880663A (en) * | 2017-03-06 | 2017-06-23 | 长沙瑞多康生物科技有限公司 | A kind of composition of prevention infectious atrophic rhinitis of pig |
| CN106901018A (en) * | 2017-03-06 | 2017-06-30 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention infectious atrophic rhinitis of pig |
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| Publication number | Publication date |
|---|---|
| CN102488746B (en) | 2014-05-28 |
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