CN102415405B - Dinotefuran micron-emulsion and preparation method thereof - Google Patents
Dinotefuran micron-emulsion and preparation method thereof Download PDFInfo
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- CN102415405B CN102415405B CN201110339065.5A CN201110339065A CN102415405B CN 102415405 B CN102415405 B CN 102415405B CN 201110339065 A CN201110339065 A CN 201110339065A CN 102415405 B CN102415405 B CN 102415405B
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- YKBZOVFACRVRJN-UHFFFAOYSA-N dinotefuran Chemical compound [O-][N+](=O)\N=C(/NC)NCC1CCOC1 YKBZOVFACRVRJN-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 239000000839 emulsion Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 238000004945 emulsification Methods 0.000 title description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000004530 micro-emulsion Substances 0.000 claims description 19
- 210000000481 breast Anatomy 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 abstract description 16
- 239000006184 cosolvent Substances 0.000 abstract description 13
- 239000002904 solvent Substances 0.000 abstract description 12
- 239000003960 organic solvent Substances 0.000 abstract description 6
- 239000000575 pesticide Substances 0.000 abstract description 6
- 230000001276 controlling effect Effects 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 18
- 239000000203 mixture Substances 0.000 description 12
- 239000000126 substance Substances 0.000 description 8
- 238000009472 formulation Methods 0.000 description 7
- 239000008187 granular material Substances 0.000 description 7
- 230000003449 preventive effect Effects 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- -1 chloro thiazolyl Chemical group 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 241000238631 Hexapoda Species 0.000 description 5
- 230000000361 pesticidal effect Effects 0.000 description 5
- 231100000053 low toxicity Toxicity 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 241000254173 Coleoptera Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 241000176086 Sogatella furcifera Species 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- NWWZPOKUUAIXIW-DHZHZOJOSA-N (E)-thiamethoxam Chemical compound [O-][N+](=O)/N=C/1N(C)COCN\1CC1=CN=C(Cl)S1 NWWZPOKUUAIXIW-DHZHZOJOSA-N 0.000 description 1
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical group CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
- FNRMMDCDHWCQTH-UHFFFAOYSA-N 2-chloropyridine;3-chloropyridine;4-chloropyridine Chemical compound ClC1=CC=NC=C1.ClC1=CC=CN=C1.ClC1=CC=CC=N1 FNRMMDCDHWCQTH-UHFFFAOYSA-N 0.000 description 1
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical compound C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 241001124076 Aphididae Species 0.000 description 1
- 241000256844 Apis mellifera Species 0.000 description 1
- 241001674044 Blattodea Species 0.000 description 1
- 241001414720 Cicadellidae Species 0.000 description 1
- 241001498622 Cixius wagneri Species 0.000 description 1
- 241000238571 Cladocera Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000256602 Isoptera Species 0.000 description 1
- 241000255777 Lepidoptera Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000257159 Musca domestica Species 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 206010058667 Oral toxicity Diseases 0.000 description 1
- 241000209094 Oryza Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010059516 Skin toxicity Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- 241001414989 Thysanoptera Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000005338 heat storage Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 231100000418 oral toxicity Toxicity 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 231100000438 skin toxicity Toxicity 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the field of pesticide preparations, and provides a dinotefuran micron-emulsion and a preparation method thereof. The dinotefuran micron-emulsion comprises components of, by weight: 1-40% of dinotefuran, 10-30% of a solvent, 10-25% of a surfactant, 5-15% of a co-solvent, and balance of water. The dinotefuran micron-emulsion provided by the invention is advantaged in low cost, simple preparation process, low packaging requirement, reduced organic solvent dosage, low residue, and small pollution on the environment. The controlling effect provided by the dinotefuran micron-emulsion is higher than that of dinotefuran particle preparations. Therefore, the dinotefuran micron-emulsion is suitable to be broadly popularized.
Description
Technical field
The present invention relates to pesticidal preparations field, relate to specifically a kind of dinotefuran micron-emulsion and preparation method thereof.
Background technology
MTI-446 (dinotefuran), chemical name is (RS)-1-methyl-2-nitro-3-[(3-oxolane)-methyl] guanidine, it is the third generation nicotinic insecticide of Mitsui chemical company exploitation, the chemical constitution of itself and existing nicotinic insecticide is far from each other, chloro-pyridine base, chloro thiazolyl before its tetrahydrofuran base has replaced, containing halogen.Meanwhile, also different with nicotine at aspect of performance.Be mainly used in preventing and treating aphid, leafhopper, plant hopper, thrips, aleyrodid and the resistant strain thereof in the various crop such as wheat, paddy rice, cotton, vegetables, fruit tree, tobacco leaf, coleoptera, diptera, Semiptera, Lepidoptera, beetle order and total wing order insect are had efficiently simultaneously, and the sanitary insect pests such as blattaria, termite, housefly are had efficiently.Fool proof to mammal, rat acute is low toxicity through skin and Oral toxicity; To fish and water flea low toxicity; To honeybee safety; Without teratogenesis, carcinogenic and mutagenesis.
The formulation of the MTI-446 pesticide product of applying on pesticide market is at present mainly take granule as main, if but the preventive effect of MTI-446 granule wants the level that reaches higher just need to increase formulation rate, this understands cause very large pollution to environment.
Simultaneously, along with the raising of people's environmental consciousness, to the restriction increasingly stringent of the organic solvent using in pesticidal preparations, thereby impel pesticidal preparations along efficient, low toxicity, with the good future development of Environmental compatibility, exploitation uses no or little the novel form of organic solvent, to replace pesticidal preparations, wherein the pesticides new formulation take water as matrix has become the direction of world pesticide dosage form research and development.
Microemulsion (microemulsion, ME) is take water as matrix, the novel green pesticidal preparations that utilize that physicochemical liquid-liquid dispersion system is theoretical and that method is prepared is efficient, store and transport safety, environmental pollution is low.Microemulsion has reduced consumption of organic solvent, has greatly alleviated the pressure to environment, significant for protection Agro-ecology balance, is more conducive to agriculture sustainable development.Therefore a kind of efficient, low toxicity of research and development, environment amenable MTI-446 pest killing micro emulsion are of great significance.
Summary of the invention
In view of this, the object of the invention is to provide a kind of efficient, little, environment amenable dinotefuran micron-emulsion of formulation rate.
For realizing object of the present invention, the present invention adopts following technical scheme:
A kind of dinotefuran micron-emulsion, comprise MTI-446, solvent, surfactant, cosolvent and water, wherein, the percentage by weight that each component accounts for described microemulsion gross weight is MTI-446 1-40%, organic solvent 10-30%, surfactant 10-25%, cosolvent 5-15%, and surplus is water;
Dinotefuran micron-emulsion of the present invention is take MTI-446 as active component, and as preferably, the percentage by weight that described MTI-446 accounts for described microemulsion gross weight is 5-20%.
Solvent of the present invention is selected from cyclohexanone, toluene, dimethylbenzene, DMSO, dimethyl formamide.
As preferably, the percentage by weight that described solvent accounts for described microemulsion gross weight is 15-20%.
Surfactant of the present invention is selected from one or more in compound, anion and the non-ionic surface active agent of anion and non-ionic surface active agent and the compound of solvent, calcium dodecyl benzene sulfonate, styryl phenol formaldehyde resin PULLRONIC F68 block type polyethers, the polyoxyethylene nonylphenol ether of nonionic or the OPEO of nonionic.
In certain embodiments, described surfactant is agriculture breast 0201B, agriculture breast 0203B, agriculture breast 0204C, agriculture breast 2201, OP series agriculture breast or agriculture breast 500, described OP series agriculture breast is preferably agriculture breast OP-10 or agriculture breast OP-21, and described surfactant is preferably agriculture breast 0204C, agriculture breast OP-10 or agriculture breast OP-21
Cosolvent of the present invention is ethanol, propyl alcohol, isopropyl alcohol or the tert-butyl alcohol, is preferably ethanol or isopropyl alcohol.As preferably, the percentage by weight that described cosolvent accounts for described microemulsion gross weight is 10-15%.
Dinotefuran micron-emulsion of the present invention can also comprise stabilizing agent, antifreezing agent and short bleeding agent, and wherein, the percentage by weight that each component accounts for described microemulsion gross weight is: stabilizing agent 1-5% antifreezing agent, 1-5% and short bleeding agent 1-10%.
Antifreezing agent of the present invention is selected from one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol, sorbierite, urea, sucrose, glucose.Described short bleeding agent is azone, lauryl alcohol sodium sulphate, sodium lignin sulfonate or alkylphenol polyoxyethylene.Described stabilizing agent can be selected from well known in the art, conventional stabilizing agent.
The present invention also provides the preparation method of described dinotefuran micron-emulsion, according to described percentage by weight, MTI-446 is fully mixed with surfactant, cosolvent, then add other compositions, mixes, and finally adds water, after fully stirring, can be made into microemulsion.
Physicochemical property and field control effectiveness test result show, dinotefuran micron-emulsion stable performance of the present invention, transparent wide ranges, resolution ratio are low, rice fulgorid is had to significant drug effect, and compared with the MTI-446 granule of same dose (in active component), preventive effect is apparently higher than the preventive effect of granule.Show that dinotefuran micron-emulsion of the present invention need not increase formulation rate and can reach higher preventive effect, alleviated farm chemical ingredients and increased the pressure bringing to environment.
From above technical scheme, Diacloden microemulsion cost of the present invention is low, and preparation process is simple, packing instructions are low, reduced the usage amount of organic solvent simultaneously, residual few, environmental pollution is little, and preventive effect is higher than MTI-446 granule, suits large area to popularize.
Embodiment
The embodiment of the invention discloses a kind of dinotefuran micron-emulsion and preparation method thereof.Those skilled in the art can use for reference content herein, suitably improve technological parameter and realize.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the artly, they are all deemed to be included in the present invention.Product of the present invention is described by preferred embodiment, and related personnel obviously can change product as herein described in content of the present invention, spirit and scope or suitably change and combination not departing from, and realizes and apply the technology of the present invention.
In order further to understand the present invention, below in conjunction with embodiment, the present invention is described in detail.
Embodiment 1:5% dinotefuran micron-emulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, then add water, after fully stirring, can be made into microemulsion.
Embodiment 2: physicochemical property is measured
Get dinotefuran micron-emulsion prepared by embodiment 1 and carry out physicochemical property test, result is as follows:
Outward appearance: as clear as crystal single-phase liquid;
Transparency temperature region: bear 5 ℃ to more than 60 ℃;
Low-temperature stability: do not occur layering, crystallization for 2 weeks at-5 ℃;
Heat storage stability: 2 weeks active ingredient resolution ratios are less than 3% at (54 ± 2) ℃;
Stability of emulsion: with the water-reducible emulsion-stabilizing of any ratio;
Ageing stability: stable under normal temperature.
Embodiment 3: field control effectiveness test
Get dinotefuran micron-emulsion and commercially available certain MTI-446 granule prepared by embodiment 1 and carry out field control effectiveness test.5 processing are established in test, and each formulation rate is in table 1, and every processing repeats for 4 times, and with reference to the Ministry of Agriculture " pesticide field efficacy medicine test criterion ", after dispenser, a borer population of each investigation in 1-3 days, 7 days, adds up and calculate preventive effect and the results are shown in Table 1.Insect population decline rate and control efficiency are calculated by following formula.
Wherein, PT
0represent the front borer population of living of chemicals treatment district medicine; PT
1borer population alive after expression chemicals treatment district medicine; CK
0represent the front borer population of living of blank district medicine; CK
1borer population alive after expression blank district medicine; PT represents chemicals treatment district insect population decline rate; CK represents blank district insect population decline rate.
Table 1 5% dinotefuran micron-emulsion to rice fulgorid control efficiency (7d)
From table 1 result, the drug effect of 5% dinotefuran micron-emulsion 20g/ mu is 71.5%, drug effect significant difference with 1% MTI-446 granule 100g/ mu, both effective ingredient consumption are 1g/ mu, show the good drug efficacy of dinotefuran micron-emulsion of the present invention, need not increase formulation rate and can reach higher preventive effect, alleviate farm chemical ingredients and increased the pressure bringing to environment.
Embodiment 4:10% dinotefuran micron-emulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, and then add other compositions to mix, then add water, after fully stirring, can be made into microemulsion.Physicochemical property test indices and field control effectiveness test result are similar to embodiment 1.
Embodiment 5:15% dinotefuran micron-emulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, and then add other compositions to mix, then add water, after fully stirring, can be made into microemulsion.Physicochemical property test indices and field control effectiveness test result are similar to embodiment 1.
Embodiment 6:20% dinotefuran micron-emulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, and then add other compositions to mix, then add water, after fully stirring, can be made into microemulsion.Physicochemical property test indices and field control effectiveness test result are similar to embodiment 1.
Embodiment 7:25% dinotefuran micron-emulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, then add water, after fully stirring, can be made into microemulsion.Physicochemical property test indices and field control effectiveness test result are similar to embodiment 1.
Embodiment 8:30% dinotefuran micron-emulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, then add water, after fully stirring, can be made into microemulsion.Physicochemical property test indices and field control effectiveness test result are similar to embodiment 1.
Embodiment 9:40% dinotefuran micron-emulsion
MTI-446 is fully mixed with solvent, surfactant, cosolvent, and then add other compositions to mix, then add water, after fully stirring, can be made into microemulsion.Physicochemical property test indices and field control effectiveness test result are similar to embodiment 1.
The explanation of above embodiment is just for helping to understand method of the present invention and core concept thereof.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of the claims in the present invention.
Claims (2)
1. a dinotefuran micron-emulsion, is characterized in that, is made up of the component of following mass percent:
2. the preparation method of dinotefuran micron-emulsion described in claim 1, is characterized in that, MTI-446 is fully mixed with cyclohexanone, ethanol, agriculture breast OP-10, agriculture breast 0204C, finally adds water, after fully stirring, can be made into microemulsion.
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| CN102415405B true CN102415405B (en) | 2014-06-11 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105145617B (en) * | 2015-10-19 | 2018-06-26 | 中国农业科学院棉花研究所 | A kind of composite synergistic pesticide |
| CN105638650B (en) * | 2016-01-28 | 2018-06-01 | 南京善思生物科技有限公司 | A kind of environmental-friendly dinotefuran micron-emulsion of organic solvent-free and preparation method thereof |
| CN105532656B (en) * | 2016-01-28 | 2018-05-22 | 南京善思生物科技有限公司 | A kind of environmental-friendly dinotefuran micron-emulsion and preparation method thereof |
| CN105746566B (en) * | 2016-03-29 | 2018-09-25 | 西北农林科技大学 | A kind of trunk injection liquor containing dinotefuran |
| CN106359474A (en) * | 2016-08-31 | 2017-02-01 | 江苏星源生物科技有限公司 | Fungicidal composition for preventing and treating rice planthopper and application thereof |
| CN109984141A (en) * | 2017-12-31 | 2019-07-09 | 海南正业中农高科股份有限公司 | A kind of microemulsion containing dinotefuran |
| CN109511671A (en) * | 2018-10-19 | 2019-03-26 | 江西博邦生物药业有限公司 | Pesticide dinotefuran aqua and its preparation method |
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| CN100450360C (en) * | 2006-11-14 | 2009-01-14 | 华南理工大学 | Rotenone and dinotefuran mixed microemulsion and preparation method thereof |
| CN102204563A (en) * | 2011-04-08 | 2011-10-05 | 湖南大方农化有限公司 | Pesticide composition containing dinotefuran |
| CN102217639A (en) * | 2011-04-21 | 2011-10-19 | 青岛海利尔药业有限公司 | Insecticidal composition containing dinotefuran and chlorantraniliprole |
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2011
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450360C (en) * | 2006-11-14 | 2009-01-14 | 华南理工大学 | Rotenone and dinotefuran mixed microemulsion and preparation method thereof |
| CN102204563A (en) * | 2011-04-08 | 2011-10-05 | 湖南大方农化有限公司 | Pesticide composition containing dinotefuran |
| CN102217639A (en) * | 2011-04-21 | 2011-10-19 | 青岛海利尔药业有限公司 | Insecticidal composition containing dinotefuran and chlorantraniliprole |
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