CN102319360B - Traditional Chinese medicine composition used for treating mammary gland hyperplasia, and preparation method thereof - Google Patents
Traditional Chinese medicine composition used for treating mammary gland hyperplasia, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition used for treating mammary gland hyperplasia, and a preparation method thereof. The composition comprises raw materials of: 84 parts of mix-fried Chinese thorowax root, 84 parts of stir-fried white peony root, 63 parts of mix-fried nutgrass galingale rhizome, 84 parts of figwort, 105 parts of kelp, 63 parts of mongolian snakegourd fruit, 105 parts of common selfheal spike, 84 parts of oyster, 63 parts of ligusticum, 84 parts of catclaw buttercup root tuber, 63 parts of baikal skullcap root, 84 parts of salvia miltiorrhiza, 42 parts of paniculate bolbostemma bulb, 21 parts of pseudobulbus cremastrae seu pleiones, 21 parts of scorpion, and 84 parts of tree peony bark. The raw materials are extracted and purified according to certain technologies; pharmaceutically acceptable auxiliary materials are added to the obtained material, and the traditional Chinese medicine composition is prepared. The traditional Chinese medicine composition has advantages of simple and feasible preparation technology, safe and effective property, and substantial pharmacological medicine efficacy.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of cyclomastopathy and preparation method thereof, belong to the pharmaceutical preparations technology field.
Background technology
Cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of carrying out property connective tissue, and its pathogenic factor mainly is because the endocrine hormone imbalance.Cyclomastopathy is the modal cystic hyperplasia of breast of women, there is 70%～85% women that in various degree cyclomastopathy is arranged according to investigations approximately, this disease presents the trend that sickness rate rises year by year, the morbidity crowd more and more becomes younger in recent years, be more common in 20～45 years old women, or account for the women of child-bearing age's 30%～45%, not only show as the newborn leaf and the nodositas granule that thicken, three big sings and symptomses such as distending pain of the breast and nipple galactorrhea, and there is the possibility of canceration in it, can not adopt a casual attitude, daily life will be paid attention to prevention and active treatment.
The tradition traditional Chinese medical science thinks that it is because depressed rage impairing the liver, worry impairing spleen, qi stagnation blood stasis, expectorant congeal into due to the nuclear, and Chinese medicine is referred to as " nodules of the breast ".Method such as should adopt dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, the kidney invigorating to transfer to dash in the treatment, can the single usefulness of a method, also denumerable method is share.Solve the cyclomastopathy problem with the method for Chinese medicine and more and more come into one's own, Chinese medicine is on curing mammary gland hyperplasia, and following advantage is arranged: 1. prevention effect is remarkable; 2. have no side effect; 3. there is not operation wound; 4. patient's relapse rate is low.Therefore, solve the new trend that cyclomastopathy problem has clinically become development with Chinese medicine, can reach treating both the principal and secondary aspects of a disease, the absolute advantages that side effect is little has vast potential for future development to development and the exploitation of this type of medicine.
Between this; we have successively applied for patent of invention and have obtained mandate; application number is in 02153458.6 patent application document; mainly be from preparation prescription; aspects such as dosage form preparation technology are protected; the present invention carries out a large amount of experimentatioies on this basis; further improve its preparation process; change pharmaceutical forms of administration; be purpose to improve curative effect of medication, to increase medicine stability and promote drug bioavailability, and creationary a kind of Chinese medicine preparation for the treatment of cyclomastopathy of succeeding in developing.
Summary of the invention
The object of the present invention is to provide that a kind of curative effect is superior, the extract oral liquid preparation of taking convenience, more scientific and reasonable, the stay-in-grade treatment cyclomastopathy of preparation technology.The medicine that the present invention prepares is through corresponding pharmacodynamics test and clinical application research, and the result shows this Chinese medicine preparation stable curative effect, effective, reliable, rapid.
Technical solution of the present invention is to be prepared from by following technology:
A. raw material is formed: process 84 parts of Radix Bupleuri, 84 parts of Radix Paeoniae Alba (parched)s, 63 parts of prepared RHIZOMA CYPERIs, 84 parts of Radix Scrophulariaes, 105 parts of Thallus Laminariae (Thallus Eckloniae)s, 63 parts of Fructus Trichosanthis, 105 parts of Spica Prunellaes, 84 parts of Concha Ostreaes, 63 parts of Radix Angelicae Sinensis, 84 parts of Radix Ranunculi Ternatis, 63 parts of Radix Scutellariaes, 84 parts of Radix Salviae Miltiorrhizaes, 42 parts of Rhizoma Bolbostematiss, 21 parts of Pseudobulbus Cremastrae Seu Pleioness, 21 parts of Scorpios, 84 parts of Cortex Moutans;
B. with 16 flavor raw material of Chinese medicine among the above-mentioned A, operate by following step:
(1) get the recipe quantity Scorpio, Concha Ostreae powder is broken into fine powder, adds the ultrasonic pretreatment of an amount of ethanol, soak at room temperature extracts then, extracting solution filters, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill in right amount, centrifugal, upper strata centrifugal liquid is standby;
(2) get recipe quantity Rhizoma Cyperi, Cortex Moutan, Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, add suitable quantity of water, it is standby that heating extraction volatile oil, extracting solution filter back water liquid, and it is standby that volatile oil adds an amount of propylene glycol dissolving;
(3) get the recipe quantity Rhizoma Bolbostematis and pulverize, decoct with water twice with Thallus Laminariae (Thallus Eckloniae), Radix Ranunculi Ternati, Pseudobulbus Cremastrae Seu Pleiones, each 1h merges decoction liquor, after the filtration, and filtrate for later use;
(4) get recipe quantity Radix Scrophulariae, Radix Salviae Miltiorrhizae, Fructus Trichosanthis, Spica Prunellae, Radix Scutellariae adding alcohol reflux twice, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill in right amount, centrifugal, upper strata centrifugal liquid is standby, medicinal residues add water and decoct twice, each 1h, merge extractive liquid,, filter filtrate for later use;
(5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to the clear paste that relative density is 1.05-1.15, add ethanol and make and contain the alcohol amount and reach 70-90%, cold preservation is left standstill, and is centrifugal, the upper strata filtrate for later use;
(6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to quantitatively, namely.
Technical solution of the present invention specifically is prepared from by following steps:
A. raw material is formed: process 84 parts of Radix Bupleuri, 84 parts of Radix Paeoniae Alba (parched)s, 63 parts of prepared RHIZOMA CYPERIs, 84 parts of Radix Scrophulariaes, 105 parts of Thallus Laminariae (Thallus Eckloniae)s, 63 parts of Fructus Trichosanthis, 105 parts of Spica Prunellaes, 84 parts of Concha Ostreaes, 63 parts of Radix Angelicae Sinensis, 84 parts of Radix Ranunculi Ternatis, 63 parts of Radix Scutellariaes, 84 parts of Radix Salviae Miltiorrhizaes, 42 parts of Rhizoma Bolbostematiss, 21 parts of Pseudobulbus Cremastrae Seu Pleioness, 21 parts of Scorpios, 84 parts of Cortex Moutans;
B. with 16 flavor raw material of Chinese medicine among the above-mentioned A, operate by following step:
(1) get the recipe quantity Scorpio, Concha Ostreae powder is broken into 80-120 order fine powder, adding with the medical material weight ratio is the ultrasonic pretreatment 20-60min of 60-90% ethanol that 15-18 doubly measures, soak at room temperature extracts 12-36h then, extracting solution filters, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 12-24h in right amount, centrifugal, upper strata centrifugal liquid is standby;
(2) get recipe quantity Rhizoma Cyperi, Cortex Moutan, Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, adding with the medical material weight ratio is 10-15 times of water gaging, and it is standby that heating extraction volatile oil 2-6h, extracting solution filter back water liquid, and it is standby that volatile oil adds an amount of propylene glycol dissolving;
(3) get the recipe quantity Rhizoma Bolbostematis and pulverize, adding with the medical material weight ratio with Thallus Laminariae (Thallus Eckloniae), Radix Ranunculi Ternati, Pseudobulbus Cremastrae Seu Pleiones is that 8-12 times of water gaging decocts twice, and each 1h merges decoction liquor, after the filtration, and filtrate for later use;
(4) getting recipe quantity Radix Scrophulariae, Radix Salviae Miltiorrhizae, Fructus Trichosanthis, Spica Prunellae, Radix Scutellariae adding and medical material weight ratio is the 70-90% alcohol reflux twice that 8-12 doubly measures, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 12-24h in right amount, centrifugal, upper strata centrifugal liquid is standby, it is that 8-12 times of water gaging decocts twice that medicinal residues add with the medical material weight ratio, each 1h, merge extractive liquid,, filter filtrate for later use;
(5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to the clear paste that relative density is 1.05-1.15, add ethanol and make and contain the alcohol amount and reach 70-90%, 12-24h is left standstill in cold preservation, and is centrifugal, the upper strata filtrate for later use;
(6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to quantitatively, namely.
Optimal technical scheme of the present invention is to be prepared from by following steps:
A. raw material is formed: process 84 parts of Radix Bupleuri, 84 parts of Radix Paeoniae Alba (parched)s, 63 parts of prepared RHIZOMA CYPERIs, 84 parts of Radix Scrophulariaes, 105 parts of Thallus Laminariae (Thallus Eckloniae)s, 63 parts of Fructus Trichosanthis, 105 parts of Spica Prunellaes, 84 parts of Concha Ostreaes, 63 parts of Radix Angelicae Sinensis, 84 parts of Radix Ranunculi Ternatis, 63 parts of Radix Scutellariaes, 84 parts of Radix Salviae Miltiorrhizaes, 42 parts of Rhizoma Bolbostematiss, 21 parts of Pseudobulbus Cremastrae Seu Pleioness, 21 parts of Scorpios, 84 parts of Cortex Moutans;
B. with 16 flavor raw material of Chinese medicine among the above-mentioned A, operate by following step:
(1) get the recipe quantity Scorpio, Concha Ostreae powder is broken into 100 order fine powders, adding with the medical material weight ratio is the ultrasonic pretreatment 40min of 80% ethanol of 16 times of amounts, soak at room temperature extracts 24h then, extracting solution filters, and filtrate decompression is concentrated into does not have the alcohol flavor, after adding water 200ml and leaving standstill 18h, centrifugal, upper strata centrifugal liquid is standby;
(2) get recipe quantity Rhizoma Cyperi, Cortex Moutan, Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, adding with the medical material weight ratio is 12 times of water gagings, and it is standby that heating extraction volatile oil 3h, extracting solution filter back water liquid, and it is standby that volatile oil adds 6% propylene glycol 3ml dissolving;
(3) get the recipe quantity Rhizoma Bolbostematis and pulverize, adding with the medical material weight ratio with Thallus Laminariae (Thallus Eckloniae), Radix Ranunculi Ternati, Pseudobulbus Cremastrae Seu Pleiones is that 10 times of water gagings decoct twice, and each 1h merges decoction liquor, after the filtration, and filtrate for later use;
(4) getting recipe quantity Radix Scrophulariae, Radix Salviae Miltiorrhizae, Fructus Trichosanthis, Spica Prunellae, Radix Scutellariae adding and medical material weight ratio is 75% alcohol reflux twice of 10 times of amounts, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water 200ml and leaving standstill 20h, centrifugal, upper strata centrifugal liquid is standby, it is that 10 times of water gagings decoct twice that medicinal residues add with the medical material weight ratio, each 1h, merge extractive liquid,, filter filtrate for later use;
(5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to relative density and be 1.10 clear paste, add ethanol and make and contain the alcohol amount and reach 80%, 18h is left standstill in cold preservation, and is centrifugal, the upper strata filtrate for later use;
(6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to quantitatively, namely.
Technical solution of the present invention than the patent 02153458.6 in first to file, mainly has following creationary useful technique effect in the middle of the research process of reality:
(1) extraction process aspect
1. pay attention to the extraction and application of medical material volatile oil:
Prescription of the present invention is by processing Radix Bupleuri, Radix Paeoniae Alba (parched), 16 flavor Chinese crude drugs such as prepared RHIZOMA CYPERI are formed, Rhizoma Cyperi wherein, Cortex Moutan, Radix Bupleuri, the Radix Paeoniae Alba, the volatile oil and the aqueous soluble active constituent that all contain more amount in the Radix Angelicae Sinensis five tastes medical material, therefore, after earlier it being carried out steam distillation extraction volatile oil, and with in the suitable cosolvent dissolving back adding medicine, water liquid after the extraction is continued to employ, not only guarantee the operability of stability of formulation and subsequent technique, and the volatile oil of fully purifying, the water solublity effective constituents, medicament curative effect enhancement, reduce operating procedure simultaneously, improve extraction efficiency.
2. pay attention to the processing of unique medical material:
In the present invention's prescription, the Concha Ostreae large usage quantity has resolving phlegm and softening hard masses, the yin fluid astringing YANG hyperactivity suppressing, and the effect of hidroschesis arresting seminal emission, but quality is hard, and water absorption is relatively poor, but is easy to pulverize; Scorpio belongs to animal drugs, and is comparatively uncommon expensive, has endogenous wind stopping spasmolytic, dispersing pathogen accumulation, and the removing obstruction in the collateral to relieve pain effect, its effective ingredient is mainly charybdotoxin class animal proteinum, is subject to destruction during heating extraction; Therefore with behind both fine powders, with extract at room temperature after soak with ethanol and the ultrasonic pretreatment.Fine-powdered can be destroyed the cell tissue of medical material, increases the contact area of medical material and solvent, is conducive to the leaching of effective ingredient; After the medical material ultrasonic pretreatment, its extraction ratio of effective constituents significantly improves, mainly be by cavitation effect of ultrasonic waves, vibration effect and heating effect, make that crude drug cell, connective tissue etc. are further destroyed, thereby accelerate release and the stripping of effective ingredient; The room temperature merceration extracts the strong permeability characteristic can utilize ethanol, slowly, continue, effectively extract the medical material effective ingredient.Triplicity is not only avoided effective ingredient to be heated and is easily gone to pot, and is a very big saving to production cost and production capacity, finally is of value to the popularization of industrialization.
3. extract according to the physical characteristic refinement classification of different medical material effective ingredient:
Discover that aspect the treatment hyperplasia of mammary glands, Rhizoma Bolbostematis, Thallus Laminariae (Thallus Eckloniae), Radix Ranunculi Ternati, that Pseudobulbus Cremastrae Seu Pleiones contains aqueous soluble active constituent is on the high side, the suitable water boiling and extraction of using through a large amount of craft screenings; The water solublity of Radix Scrophulariae, Fructus Trichosanthis, Spica Prunellae, Radix Salviae Miltiorrhizae, Radix Scutellariae, pure soluble substance all have therapeutical effect, and therefore the technology that water is carried after the suitable first alcohol extraction extracted medical material refinement classification, not only with strong points, it is highly concentrated that effective ingredient reaches, and energy savings, obviously reduces production costs.
(2) clinical practice aspect
Be to be that improve on 02153458.6 basis at application number owing to content of the present invention, so we are in the contrast of clinical research stage high spot reviews and the disclosure technical scheme.Because writing out a prescription, both form and the identical Chinese medicine preparation preparation technology of ratio, in line with contrast experiment's principle parallel, reasonable, that save, we bring different must the disturbing of curative effect at the dosage form difference of forgoing under study for action, only compare the two drug effect difference in the medicinal material extract purifying process, namely respectively the two all being made oral liquid according to extraction process scheme separately takes, or dried cream powder brews the mode of taking with boiled water and compares, medication preparation of the present invention is that representative is studied with the optimal technical scheme, and particular content is as follows:
1. data and method
1.1 clinical data
186 routine patients are included in this experiment altogether in, are divided into three groups at random, medicine group 63 examples of the present invention wherein, 02153458.6 group of 65 example of application number, blank group 58 examples.Age is in 20-56 year, average (36.25 ± 5.28) year, three groups of patient ages distribute and do not have showing property differences.Mastalgia adopts 0-10 numeral strength grading method: the first order is (0 minute) not bitterly; Second level mild pain (1-3 branch); Third level moderate pain (4-6 branch); Fourth stage severe pain (7-9); Level V is pain (10 minutes) extremely.Patient's pain rank, be the results are shown in (table 1) on corresponding numeral by patient's circle
Three groups of patient's medications of table 1 fore udder lump draw ratio
The result shows that three groups of patients are at medication fore udder lump major diameter there was no significant difference.
Three groups of patient's medications of table 2 fore udder pain scores relatively
The result shows that three groups of patients are at medication fore udder pain degree there was no significant difference.
1.2 medicine is prepared
1.2.1 medication preparation of the present invention:
(1) gets Scorpio 21g, Concha Ostreae 84g and be ground into 100 order fine powders, adding with the medical material weight ratio is the ultrasonic pretreatment 40min of 80% ethanol of 16 times of amounts, 20-25 ℃ is soaked extraction 24h then, extracting solution filters, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water 200ml and leaving standstill 18h, centrifugal, upper strata centrifugal liquid is standby; (2) get Rhizoma Cyperi 63g, Cortex Moutan 84g, Radix Bupleuri 84g, Radix Paeoniae Alba 84g, Radix Angelicae Sinensis 63g, adding with the medical material weight ratio is 12 times of water gagings, and it is standby that heating extraction volatile oil 3h, extracting solution filter back water liquid, and it is standby that volatile oil adds 6% propylene glycol 3ml dissolving; (3) the Bulbus Fritillariae Uninbracteatae 42g that fetches earth pulverizes, and adding with the medical material weight ratio with Thallus Laminariae (Thallus Eckloniae) 105g, Radix Ranunculi Ternati 84g, Pseudobulbus Cremastrae Seu Pleiones 21g is that 10 times of water gagings decoct twice, and each 1h merges decoction liquor, after the filtration, and filtrate for later use; (4) getting Radix Scrophulariae 84g, Radix Salviae Miltiorrhizae 84g, Fructus Trichosanthis 63g, Spica Prunellae 105g, Radix Scutellariae 63g adding and medical material weight ratio is 75% alcohol reflux twice of 10 times of amounts, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water 200ml and leaving standstill 20h, centrifugal, upper strata centrifugal liquid is standby, it is that 10 times of water gagings decoct twice that medicinal residues add with the medical material weight ratio, each 1h, merge extractive liquid,, filter filtrate for later use; (5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to relative density and be 1.10 clear paste, add ethanol and make and contain the alcohol amount and reach 80%, 18h is left standstill in cold preservation, and is centrifugal, the upper strata filtrate for later use; (6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to 1000ml, namely.
1.2.2 application number 02153458.6 medication preparation:
(1) get Rhizoma Cyperi 63g, Scorpio 21g, Cortex Moutan 84g three flavor medical materials, be ground into fine powder, standby; (2) get Radix Bupleuri 84g, Radix Angelicae Sinensis 63g, Radix Scrophulariae 84g, Radix Salviae Miltiorrhizae 84g, the Rhizoma Bolbostematis 42g five tastes, add 60% alcohol reflux secondary, each 1.5 hours, filter, filtrate decompression concentrates, and clear paste is standby; (3) get Radix Paeoniae Alba 84g, Thallus Laminariae (Thallus Eckloniae) 105g, Fructus Trichosanthis 63g, Spica Prunellae 105g, Concha Ostreae 84g, Radix Ranunculi Ternati 84g, Radix Scutellariae 63g, Pseudobulbus Cremastrae Seu Pleiones 21g in addition, decoct with water secondary, 1.5 hours for the first time, 1.0 hours for the second time, filter, filtrate merges, concentrating under reduced pressure, gained clear paste add ethanol to be made and contains alcohol amount and reach 50%, cold preservation 24 hours, filter, filtrate decompression concentrates, and adds above-mentioned clear paste, and continue to be condensed into thick paste, and drying under reduced pressure, dried cream powder is broken, be blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing, namely.Dried cream powder is converted water 1000ml before taking, and shakes up and takes.
1.3 Therapeutic Method
All administration groups are all taked the oral administration mode, each 10ml, 3 times/d; The blank group gives pure water, each 10ml, and 3 times/d, 20d is a course for the treatment of.
1.4 curative effect determinate standard
1. clinical recovery: mastalgia and mammary gland tumor disappear.2. produce effects: mastalgia disappears, and heavy type becomes light-duty, and mammary gland tumor dwindles 〉=and 1/2.3. effective: mastalgia alleviates or disappears, and medium-sizedly becomes light-dutyly, and heavy type becomes medium-sized, and lump in breast dwindles≤and 1/2.4. invalid: mastalgia does not alleviate, and mammary gland tumor is not dwindled or increase person on the contrary.
1.5 cyclomastopathy diagnostic criteria
The standard that the cyclomastopathy diagnostic criteria is formulated with reference to the 8th meeting of Chinese surgery of Chinese medicine breast disease Professional Committee of association in 2002.
1.5.1 symptom and sign
1. breast feels to have distending pain, twinge or the dull pain of varying level, and pain 3 months or interruption pain were not alleviated in 3～6 months continuously.Pain can emit to oxter, position such as shoulder back etc., has certain dependency with the variation of menstruation, emotion.2. lump appears in the one or both sides breast, the lump characteristics be single or multiplely differ in size, form is various, not obvious with the surrounding tissue boundary, with skin or deep tissue adhesion, what push away is motionless, the sense of tenderness is arranged, be subjected to the influence that emotion and menstrual cycle change, pruritus or discharge can appear in part patient's nipple.
1.5.2 exclusion standard
Get rid of malignant tumor of breast, gynecomastia and the preceding children's's breast development of menophania disease.
1.5.3 carry out auxiliary examination
Comprise that aluminum target X line takes the photograph sheet, puncture cytology or histological examination, B ultrasonic, mammary gland fiber duct mirror.All have one of an above-mentioned symptom and sign performance person, the person that meets the exclusion standard, and can carry out the diagnosis of cyclomastopathy in conjunction with the corresponding auxiliary examination person of meeting.
1.6 state of an illness weight classification
1. light-duty: mastalgia is dull pain, scurry pain, and one-sided or bilateral lump in breast for single lump or to be the graininess scope little, or is streak thing, and is softer, is confined to a quadrant.2. medium-sized: mastalgia is dull pain or scurries pain and tenderness is arranged that swell and ache obviously, lump is bigger, is sheet pain, plate-like, involve two breasts, but scope is at two quadrants.3. heavy: mastalgia is touched a tender spot obviously for weighing down pain or twinge, and lump is bigger.Multiple tuberosity involves two breasts, and scope is at two more than the quadrant.
2 results
Take the cyclomastopathy patient of 02153458.6 group for the treatment of of medicine of the present invention and application number, its total effective rate and blank group are relatively, significant differences is all arranged, total effective rate all reaches more than 92%, and compare mutually between two groups, medicine group of the present invention reaches significant difference having a clear superiority in aspect cure rate, the obvious effective rate.
Total effects relatively behind three groups of patient treatments of table 3
Annotate: compare * * * P＜0.01 with the blank group; Compare #P＜0.05 for 02153458.6 group with application number.
The specific embodiment
Below be the specific embodiment of content of the present invention, be used for setting forth the concrete technical scheme that present specification is wanted the technical solution problem, help those skilled in the art to understand content of the present invention.But the realization of technical solution of the present invention is not limited to these embodiment.
Embodiment 1
(1) get Scorpio 21g, Concha Ostreae 84g and be ground into 80 order fine powders, adding with the medical material weight ratio is the ultrasonic pretreatment 20min of 90% ethanol of 15 times of amounts, and soak at room temperature extracts 12h then, extracting solution filters, and filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 12h in right amount, centrifugal, upper strata centrifugal liquid is standby; (2) get Rhizoma Cyperi 63g, Cortex Moutan 84g, Radix Bupleuri 84g, Radix Paeoniae Alba 84g, Radix Angelicae Sinensis 63g, adding with the medical material weight ratio is 10 times of water gagings, and it is standby that heating extraction volatile oil 6h, extracting solution filter back water liquid, and it is standby that volatile oil adds an amount of propylene glycol dissolving; (3) the Bulbus Fritillariae Uninbracteatae 42g that fetches earth pulverizes, and adding with the medical material weight ratio with Thallus Laminariae (Thallus Eckloniae) 105g, Radix Ranunculi Ternati 84g, Pseudobulbus Cremastrae Seu Pleiones 21g is that 8 times of water gagings decoct twice, and each 1h merges decoction liquor, after the filtration, and filtrate for later use; (4) getting Radix Scrophulariae 84g, Radix Salviae Miltiorrhizae 84g, Fructus Trichosanthis 63g, Spica Prunellae 105g, Radix Scutellariae 63g adding and medical material weight ratio is 70% alcohol reflux twice of 8 times of amounts, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 24h in right amount, centrifugal, upper strata centrifugal liquid is standby, it is that 8 times of water gagings decoct twice that medicinal residues add with the medical material weight ratio, each 1h, merge extractive liquid,, filter filtrate for later use; (5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to relative density and be 1.05 clear paste, add ethanol and make and contain the alcohol amount and reach 90%, 12h is left standstill in cold preservation, and is centrifugal, the upper strata filtrate for later use; (6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to 1000ml, namely.
Embodiment 2
(1) get Scorpio 21g, Concha Ostreae 84g and be ground into 120 order fine powders, adding with the medical material weight ratio is the ultrasonic pretreatment 60min of 60% ethanol of 18 times of amounts, and soak at room temperature extracts 36h then, extracting solution filters, and filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 24h in right amount, centrifugal, upper strata centrifugal liquid is standby; (2) get Rhizoma Cyperi 63g, Cortex Moutan 84g, Radix Bupleuri 84g, Radix Paeoniae Alba 84g, Radix Angelicae Sinensis 63g, adding with the medical material weight ratio is 15 times of water gagings, and it is standby that heating extraction volatile oil 2h, extracting solution filter back water liquid, and it is standby that volatile oil adds an amount of propylene glycol dissolving; (3) the Bulbus Fritillariae Uninbracteatae 42g that fetches earth pulverizes, and adding with the medical material weight ratio with Thallus Laminariae (Thallus Eckloniae) 105g, Radix Ranunculi Ternati 84g, Pseudobulbus Cremastrae Seu Pleiones 21g is that 12 times of water gagings decoct twice, and each 1h merges decoction liquor, after the filtration, and filtrate for later use; (4) getting Radix Scrophulariae 84g, Radix Salviae Miltiorrhizae 84g, Fructus Trichosanthis 63g, Spica Prunellae 105g, Radix Scutellariae 63g adding and medical material weight ratio is 90% alcohol reflux twice of 12 times of amounts, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 12h in right amount, centrifugal, upper strata centrifugal liquid is standby, it is that 12 times of water gagings decoct twice that medicinal residues add with the medical material weight ratio, each 1h, merge extractive liquid,, filter filtrate for later use; (5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to relative density and be 1.15 clear paste, add ethanol and make and contain the alcohol amount and reach 70%, 24h is left standstill in cold preservation, and is centrifugal, the upper strata filtrate for later use; (6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to 1000ml, namely.
Embodiment 3
(1) get Scorpio 21g, Concha Ostreae 84g and be ground into 100 order fine powders, adding with the medical material weight ratio is the ultrasonic pretreatment 30min of 85% ethanol of 16 times of amounts, and soak at room temperature extracts 24h then, extracting solution filters, and filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 16h in right amount, centrifugal, upper strata centrifugal liquid is standby; (2) get Rhizoma Cyperi 63g, Cortex Moutan 84g, Radix Bupleuri 84g, Radix Paeoniae Alba 84g, Radix Angelicae Sinensis 63g, adding with the medical material weight ratio is 12 times of water gagings, and it is standby that heating extraction volatile oil 5h, extracting solution filter back water liquid, and it is standby that volatile oil adds an amount of propylene glycol dissolving; (3) the Bulbus Fritillariae Uninbracteatae 42g that fetches earth pulverizes, and adding with the medical material weight ratio with Thallus Laminariae (Thallus Eckloniae) 105g, Radix Ranunculi Ternati 84g, Pseudobulbus Cremastrae Seu Pleiones 21g is that 11 times of water gagings decoct twice, and each 1h merges decoction liquor, after the filtration, and filtrate for later use; (4) getting Radix Scrophulariae 84g, Radix Salviae Miltiorrhizae 84g, Fructus Trichosanthis 63g, Spica Prunellae 105g, Radix Scutellariae 63g adding and medical material weight ratio is 80% alcohol reflux twice of 9 times of amounts, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 16h in right amount, centrifugal, upper strata centrifugal liquid is standby, it is that 9 times of water gagings decoct twice that medicinal residues add with the medical material weight ratio, each 1h, merge extractive liquid,, filter filtrate for later use; (5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to relative density and be 1.05 clear paste, add ethanol and make and contain the alcohol amount and reach 85%, 18h is left standstill in cold preservation, and is centrifugal, the upper strata filtrate for later use; (6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to 1000ml, namely.
Claims (7)
1. Chinese medicine composition oral liquid formulations for the treatment of cyclomastopathy is characterized in that it is to be prepared from by following technology:
A. raw material is formed: process 84 parts of Radix Bupleuri, 84 parts of Radix Paeoniae Alba (parched)s, 63 parts of prepared RHIZOMA CYPERIs, 84 parts of Radix Scrophulariaes, 105 parts of Thallus Laminariae (Thallus Eckloniae)s, 63 parts of Fructus Trichosanthis, 105 parts of Spica Prunellaes, 84 parts of Concha Ostreaes, 63 parts of Radix Angelicae Sinensis, 84 parts of Radix Ranunculi Ternatis, 63 parts of Radix Scutellariaes, 84 parts of Radix Salviae Miltiorrhizaes, 42 parts of Rhizoma Bolbostematiss, 21 parts of Pseudobulbus Cremastrae Seu Pleioness, 21 parts of Scorpios, 84 parts of Cortex Moutans;
B. with 16 flavor raw material of Chinese medicine among the above-mentioned A, operate by following step:
(1) get the recipe quantity Scorpio, Concha Ostreae powder is broken into fine powder, adding concentration is the ultrasonic pretreatment of ethanol of 60%-90%, soak at room temperature extracts then, extracting solution filters, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill in right amount, centrifugal, upper strata centrifugal liquid is standby;
(2) get recipe quantity Rhizoma Cyperi, Cortex Moutan, Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, add 10-15 times of water gaging, it is standby that heating extraction volatile oil, extracting solution filter back water liquid, and it is standby that volatile oil adds an amount of propylene glycol dissolving;
(3) get the recipe quantity Rhizoma Bolbostematis and pulverize, add 8-12 times of water gaging with Thallus Laminariae (Thallus Eckloniae), Radix Ranunculi Ternati, Pseudobulbus Cremastrae Seu Pleiones and decoct twice, each 1h merges decoction liquor, after the filtration, and filtrate for later use;
(4) getting recipe quantity Radix Scrophulariae, Radix Salviae Miltiorrhizae, Fructus Trichosanthis, Spica Prunellae, Radix Scutellariae, to add concentration be the alcohol reflux twice of 70%-90%, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill in right amount, centrifugal, upper strata centrifugal liquid is standby, medicinal residues add water and decoct twice, each 1h, merge extractive liquid,, filter filtrate for later use;
(5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to the clear paste that relative density is 1.05-1.15, add ethanol and make and contain the alcohol amount and reach 70-90%, cold preservation is left standstill, and is centrifugal, the upper strata filtrate for later use;
(6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to quantitatively, namely get oral liquid formulations.
2. the Chinese medicine composition oral liquid formulations for the treatment of cyclomastopathy as claimed in claim 1 is characterized in that it is to be prepared from by following technology:
A. raw material is formed: process 84 parts of Radix Bupleuri, 84 parts of Radix Paeoniae Alba (parched)s, 63 parts of prepared RHIZOMA CYPERIs, 84 parts of Radix Scrophulariaes, 105 parts of Thallus Laminariae (Thallus Eckloniae)s, 63 parts of Fructus Trichosanthis, 105 parts of Spica Prunellaes, 84 parts of Concha Ostreaes, 63 parts of Radix Angelicae Sinensis, 84 parts of Radix Ranunculi Ternatis, 63 parts of Radix Scutellariaes, 84 parts of Radix Salviae Miltiorrhizaes, 42 parts of Rhizoma Bolbostematiss, 21 parts of Pseudobulbus Cremastrae Seu Pleioness, 21 parts of Scorpios, 84 parts of Cortex Moutans;
B. with 16 flavor raw material of Chinese medicine among the above-mentioned A, operate by following step:
(1) get the recipe quantity Scorpio, Concha Ostreae powder is broken into 80-120 order fine powder, adding with the medical material weight ratio is the ultrasonic pretreatment 20-60min of 60-90% ethanol that 15-18 doubly measures, soak at room temperature extracts 12-36h then, extracting solution filters, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 12-24h in right amount, centrifugal, upper strata centrifugal liquid is standby;
(2) get recipe quantity Rhizoma Cyperi, Cortex Moutan, Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, adding with the medical material weight ratio is 10-15 times of water gaging, and it is standby that heating extraction volatile oil 2-6h, extracting solution filter back water liquid, and it is standby that volatile oil adds an amount of propylene glycol dissolving;
(3) get the recipe quantity Rhizoma Bolbostematis and pulverize, adding with the medical material weight ratio with Thallus Laminariae (Thallus Eckloniae), Radix Ranunculi Ternati, Pseudobulbus Cremastrae Seu Pleiones is that 8-12 times of water gaging decocts twice, and each 1h merges decoction liquor, after the filtration, and filtrate for later use;
(4) getting recipe quantity Radix Scrophulariae, Radix Salviae Miltiorrhizae, Fructus Trichosanthis, Spica Prunellae, Radix Scutellariae adding and medical material weight ratio is the 70-90% alcohol reflux twice that 8-12 doubly measures, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 12-24h in right amount, centrifugal, upper strata centrifugal liquid is standby, it is that 8-12 times of water gaging decocts twice that medicinal residues add with the medical material weight ratio, each 1h, merge extractive liquid,, filter filtrate for later use;
(5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to the clear paste that relative density is 1.05-1.15, add ethanol and make and contain the alcohol amount and reach 70-90%, 12-24h is left standstill in cold preservation, and is centrifugal, the upper strata filtrate for later use;
(6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to quantitatively, namely get oral liquid formulations.
3. the Chinese medicine composition oral liquid formulations for the treatment of cyclomastopathy as claimed in claim 2 is characterized in that it is to be prepared from by following technology:
A. raw material is formed: process 84 parts of Radix Bupleuri, 84 parts of Radix Paeoniae Alba (parched)s, 63 parts of prepared RHIZOMA CYPERIs, 84 parts of Radix Scrophulariaes, 105 parts of Thallus Laminariae (Thallus Eckloniae)s, 63 parts of Fructus Trichosanthis, 105 parts of Spica Prunellaes, 84 parts of Concha Ostreaes, 63 parts of Radix Angelicae Sinensis, 84 parts of Radix Ranunculi Ternatis, 63 parts of Radix Scutellariaes, 84 parts of Radix Salviae Miltiorrhizaes, 42 parts of Rhizoma Bolbostematiss, 21 parts of Pseudobulbus Cremastrae Seu Pleioness, 21 parts of Scorpios, 84 parts of Cortex Moutans;
B. with 16 flavor raw material of Chinese medicine among the above-mentioned A, operate by following step:
(1) get the recipe quantity Scorpio, Concha Ostreae powder is broken into 100 order fine powders, adding with the medical material weight ratio is the ultrasonic pretreatment 40min of 80% ethanol of 16 times of amounts, 20-25 ℃ is soaked extraction 24h then, extracting solution filters, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water 200ml and leaving standstill 18h, centrifugal, upper strata centrifugal liquid is standby;
(2) get recipe quantity Rhizoma Cyperi, Cortex Moutan, Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, adding with the medical material weight ratio is 12 times of water gagings, and it is standby that heating extraction volatile oil 3h, extracting solution filter back water liquid, and it is standby that volatile oil adds 6% propylene glycol 3ml dissolving;
(3) get the recipe quantity Rhizoma Bolbostematis and pulverize, adding with the medical material weight ratio with Thallus Laminariae (Thallus Eckloniae), Radix Ranunculi Ternati, Pseudobulbus Cremastrae Seu Pleiones is that 10 times of water gagings decoct twice, and each 1h merges decoction liquor, after the filtration, and filtrate for later use;
(4) getting recipe quantity Radix Scrophulariae, Radix Salviae Miltiorrhizae, Fructus Trichosanthis, Spica Prunellae, Radix Scutellariae adding and medical material weight ratio is 75% alcohol reflux twice of 10 times of amounts, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water 200ml and leaving standstill 20h, centrifugal, upper strata centrifugal liquid is standby, it is that 10 times of water gagings decoct twice that medicinal residues add with the medical material weight ratio, each 1h, merge extractive liquid,, filter filtrate for later use;
(5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to relative density and be 1.10 clear paste, add ethanol and make and contain the alcohol amount and reach 80%, 18h is left standstill in cold preservation, and is centrifugal, the upper strata filtrate for later use;
(6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to quantitatively, namely get oral liquid formulations.
4. the preparation technology of the Chinese medicine composition oral liquid formulations for the treatment of cyclomastopathy as claimed in claim 1 is characterized in that it is to be prepared from by following step:
A. raw material is formed: process 84 parts of Radix Bupleuri, 84 parts of Radix Paeoniae Alba (parched)s, 63 parts of prepared RHIZOMA CYPERIs, 84 parts of Radix Scrophulariaes, 105 parts of Thallus Laminariae (Thallus Eckloniae)s, 63 parts of Fructus Trichosanthis, 105 parts of Spica Prunellaes, 84 parts of Concha Ostreaes, 63 parts of Radix Angelicae Sinensis, 84 parts of Radix Ranunculi Ternatis, 63 parts of Radix Scutellariaes, 84 parts of Radix Salviae Miltiorrhizaes, 42 parts of Rhizoma Bolbostematiss, 21 parts of Pseudobulbus Cremastrae Seu Pleioness, 21 parts of Scorpios, 84 parts of Cortex Moutans;
B. with 16 flavor raw material of Chinese medicine among the above-mentioned A, operate by following step:
(1) get the recipe quantity Scorpio, Concha Ostreae powder is broken into fine powder, adding concentration is the ultrasonic pretreatment of ethanol of 60%-90%, soak at room temperature extracts then, extracting solution filters, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill in right amount, centrifugal, upper strata centrifugal liquid is standby;
(2) get recipe quantity Rhizoma Cyperi, Cortex Moutan, Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, add 10-15 times of water gaging, it is standby that heating extraction volatile oil, extracting solution filter back water liquid, and it is standby that volatile oil adds an amount of propylene glycol dissolving;
(3) get the recipe quantity Rhizoma Bolbostematis and pulverize, add 8-12 times of water gaging with Thallus Laminariae (Thallus Eckloniae), Radix Ranunculi Ternati, Pseudobulbus Cremastrae Seu Pleiones and decoct twice, each 1h merges decoction liquor, after the filtration, and filtrate for later use;
(4) getting recipe quantity Radix Scrophulariae, Radix Salviae Miltiorrhizae, Fructus Trichosanthis, Spica Prunellae, Radix Scutellariae, to add concentration be the alcohol reflux twice of 70%-90%, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill in right amount, centrifugal, upper strata centrifugal liquid is standby, medicinal residues add water and decoct twice, each 1h, merge extractive liquid,, filter filtrate for later use;
(5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to the clear paste that relative density is 1.05-1.15, add ethanol and make and contain the alcohol amount and reach 70-90%, cold preservation is left standstill, and is centrifugal, the upper strata filtrate for later use;
(6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to quantitatively, namely.
5. the preparation technology of the Chinese medicine composition oral liquid formulations for the treatment of cyclomastopathy as claimed in claim 4 is characterized in that it is to be prepared from by following step:
A. raw material is formed: process 84 parts of Radix Bupleuri, 84 parts of Radix Paeoniae Alba (parched)s, 63 parts of prepared RHIZOMA CYPERIs, 84 parts of Radix Scrophulariaes, 105 parts of Thallus Laminariae (Thallus Eckloniae)s, 63 parts of Fructus Trichosanthis, 105 parts of Spica Prunellaes, 84 parts of Concha Ostreaes, 63 parts of Radix Angelicae Sinensis, 84 parts of Radix Ranunculi Ternatis, 63 parts of Radix Scutellariaes, 84 parts of Radix Salviae Miltiorrhizaes, 42 parts of Rhizoma Bolbostematiss, 21 parts of Pseudobulbus Cremastrae Seu Pleioness, 21 parts of Scorpios, 84 parts of Cortex Moutans;
B. with 16 flavor raw material of Chinese medicine among the above-mentioned A, operate by following step:
(1) get the recipe quantity Scorpio, Concha Ostreae powder is broken into 80-120 order fine powder, adding with the medical material weight ratio is the ultrasonic pretreatment 20-60min of 60-90% ethanol that 15-18 doubly measures, soak at room temperature extracts 12-36h then, extracting solution filters, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 12-24h in right amount, centrifugal, upper strata centrifugal liquid is standby;
(2) get recipe quantity Rhizoma Cyperi, Cortex Moutan, Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, adding with the medical material weight ratio is 10-15 times of water gaging, and it is standby that heating extraction volatile oil 2-6h, extracting solution filter back water liquid, and it is standby that volatile oil adds an amount of propylene glycol dissolving;
(3) get the recipe quantity Rhizoma Bolbostematis and pulverize, adding with the medical material weight ratio with Thallus Laminariae (Thallus Eckloniae), Radix Ranunculi Ternati, Pseudobulbus Cremastrae Seu Pleiones is that 8-12 times of water gaging decocts twice, and each 1h merges decoction liquor, after the filtration, and filtrate for later use;
(4) getting recipe quantity Radix Scrophulariae, Radix Salviae Miltiorrhizae, Fructus Trichosanthis, Spica Prunellae, Radix Scutellariae adding and medical material weight ratio is the 70-90% alcohol reflux twice that 8-12 doubly measures, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water and leaving standstill 12-24h in right amount, centrifugal, upper strata centrifugal liquid is standby, it is that 8-12 times of water gaging decocts twice that medicinal residues add with the medical material weight ratio, each 1h, merge extractive liquid,, filter filtrate for later use;
(5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to the clear paste that relative density is 1.05-1.15, add ethanol and make and contain the alcohol amount and reach 70-90%, 12-24h is left standstill in cold preservation, and is centrifugal, the upper strata filtrate for later use;
(6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to quantitatively, namely.
6. the preparation technology of the Chinese medicine composition oral liquid formulations for the treatment of cyclomastopathy as claimed in claim 5 is characterized in that it is to be prepared from by following step:
A. raw material is formed: process 84 parts of Radix Bupleuri, 84 parts of Radix Paeoniae Alba (parched)s, 63 parts of prepared RHIZOMA CYPERIs, 84 parts of Radix Scrophulariaes, 105 parts of Thallus Laminariae (Thallus Eckloniae)s, 63 parts of Fructus Trichosanthis, 105 parts of Spica Prunellaes, 84 parts of Concha Ostreaes, 63 parts of Radix Angelicae Sinensis, 84 parts of Radix Ranunculi Ternatis, 63 parts of Radix Scutellariaes, 84 parts of Radix Salviae Miltiorrhizaes, 42 parts of Rhizoma Bolbostematiss, 21 parts of Pseudobulbus Cremastrae Seu Pleioness, 21 parts of Scorpios, 84 parts of Cortex Moutans;
B. with 16 flavor raw material of Chinese medicine among the above-mentioned A, operate by following step:
(1) get the recipe quantity Scorpio, Concha Ostreae powder is broken into 100 order fine powders, adding with the medical material weight ratio is the ultrasonic pretreatment 40min of 80% ethanol of 16 times of amounts, 20-25 ℃ is soaked extraction 24h then, extracting solution filters, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water 200ml and leaving standstill 18h, centrifugal, upper strata centrifugal liquid is standby;
(2) get recipe quantity Rhizoma Cyperi, Cortex Moutan, Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, adding with the medical material weight ratio is 12 times of water gagings, and it is standby that heating extraction volatile oil 3h, extracting solution filter back water liquid, and it is standby that volatile oil adds 6% propylene glycol 3ml dissolving;
(3) get the recipe quantity Rhizoma Bolbostematis and pulverize, adding with the medical material weight ratio with Thallus Laminariae (Thallus Eckloniae), Radix Ranunculi Ternati, Pseudobulbus Cremastrae Seu Pleiones is that 10 times of water gagings decoct twice, and each 1h merges decoction liquor, after the filtration, and filtrate for later use;
(4) getting recipe quantity Radix Scrophulariae, Radix Salviae Miltiorrhizae, Fructus Trichosanthis, Spica Prunellae, Radix Scutellariae adding and medical material weight ratio is 75% alcohol reflux twice of 10 times of amounts, each 1h, merge extractive liquid,, filter, filtrate decompression is concentrated into does not have the alcohol flavor, after adding water 200ml and leaving standstill 20h, centrifugal, upper strata centrifugal liquid is standby, it is that 10 times of water gagings decoct twice that medicinal residues add with the medical material weight ratio, each 1h, merge extractive liquid,, filter filtrate for later use;
(5) (2), (3), (4) are located in water extraction filtrate merge, be evaporated to relative density and be 1.10 clear paste, add ethanol and make and contain the alcohol amount and reach 80%, 18h is left standstill in cold preservation, and is centrifugal, the upper strata filtrate for later use;
(6) with (1), (4), (5) centrifugal liquid merging at the middle and upper levels, with volatile oil solution mix homogeneously in (2), add water to quantitatively, namely.
7. the application of Chinese medicine composition oral liquid formulations as claimed in claim 1 in preparation treatment hyperplasia of mammary glands medicine.
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| CN1418683A (en) * | 2002-11-29 | 2003-05-21 | 张慧芳 | Medicine composition for treating mammary gland proliferation, and its prepn. method |
| CN1562183A (en) * | 2004-03-17 | 2005-01-12 | 北京奇源益德药物研究所 | Chinese medica preparation for curing hyperplasia of mammary glands and preparation method |
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| CN1418683A (en) * | 2002-11-29 | 2003-05-21 | 张慧芳 | Medicine composition for treating mammary gland proliferation, and its prepn. method |
| CN1562183A (en) * | 2004-03-17 | 2005-01-12 | 北京奇源益德药物研究所 | Chinese medica preparation for curing hyperplasia of mammary glands and preparation method |
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